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Network neighborhood for query Sequence : SOCS4_HUMAN

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SOCS4_HUMAN
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SOCS4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	0 (rank : 2)	NC score	0.997940 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS5_HUMAN
θ value	4.4633e-116 (rank : 3)	NC score	0.968078 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	59
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	2.2151e-115 (rank : 4)	NC score	0.967102 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	93	Shared Neighborhood Hits	59
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS6_HUMAN
θ value	7.82807e-20 (rank : 5)	NC score	0.700716 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	7.82807e-20 (rank : 6)	NC score	0.698132 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
θ value	1.29331e-14 (rank : 7)	NC score	0.678511 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

CISH_HUMAN
θ value	3.18553e-13 (rank : 8)	NC score	0.654315 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SOCS2_HUMAN
θ value	1.2105e-12 (rank : 9)	NC score	0.657042 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	104	Shared Neighborhood Hits	47
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

CISH_MOUSE
θ value	1.58096e-12 (rank : 10)	NC score	0.650980 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SOCS2_MOUSE
θ value	6.00763e-12 (rank : 11)	NC score	0.653383 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SOCS1_MOUSE
θ value	9.92553e-07 (rank : 12)	NC score	0.572750 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS1_HUMAN
θ value	1.29631e-06 (rank : 13)	NC score	0.569669 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS3_HUMAN
θ value	1.43324e-05 (rank : 14)	NC score	0.529030 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	4.1701e-05 (rank : 15)	NC score	0.521254 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

P55G_HUMAN
θ value	0.00298849 (rank : 16)	NC score	0.277877 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
θ value	0.00509761 (rank : 17)	NC score	0.257776 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NCK1_HUMAN
θ value	0.00665767 (rank : 18)	NC score	0.188020 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	45
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRK_HUMAN
θ value	0.0148317 (rank : 19)	NC score	0.208897 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	51
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.0148317 (rank : 20)	NC score	0.205916 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	51
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	0.0148317 (rank : 21)	NC score	0.242254 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P55G_MOUSE
θ value	0.0148317 (rank : 22)	NC score	0.279929 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	401	Shared Neighborhood Hits	53
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

NCK2_HUMAN
θ value	0.0193708 (rank : 23)	NC score	0.179195 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	51
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

P85B_HUMAN
θ value	0.0193708 (rank : 24)	NC score	0.247843 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	543	Shared Neighborhood Hits	54
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	0.0330416 (rank : 25)	NC score	0.247409 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	519	Shared Neighborhood Hits	54
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85A_HUMAN
θ value	0.0563607 (rank : 26)	NC score	0.235306 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.236650 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	435	Shared Neighborhood Hits	55
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PLCG1_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.141113 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	0.0736092 (rank : 29)	NC score	0.139355 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	48
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RB40C_HUMAN
θ value	0.0736092 (rank : 30)	NC score	0.048645 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S21, O60795, Q4TT41	Gene names	RAB40C, RARL, RASL8C
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3) (Rar- like protein).

RB40C_MOUSE
θ value	0.0736092 (rank : 31)	NC score	0.048675 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHQ4	Gene names	Rab40c
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3).

RB40A_HUMAN
θ value	0.21417 (rank : 32)	NC score	0.050331 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	267	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXH6, O00407, Q6DK06, Q8TF06	Gene names	RAB40A
Domain Architecture
Description	Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2).

SH21B_MOUSE
θ value	0.21417 (rank : 33)	NC score	0.114392 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PLCG2_HUMAN
θ value	0.279714 (rank : 34)	NC score	0.133700 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SLAP2_MOUSE
θ value	0.47712 (rank : 35)	NC score	0.107443 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

ABL2_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.041914 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	1045	Shared Neighborhood Hits	49
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CHIO_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.060260 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

HSH2D_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.167331 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ZN33A_HUMAN
θ value	0.62314 (rank : 39)	NC score	0.000684 (rank : 98)
Query Neighborhood Hits	69	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).

VAV_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.110737 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	46
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CRKL_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.159454 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	313	Shared Neighborhood Hits	49
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

RB40L_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.042379 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P0C0E4	Gene names	RAB40AL
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-40A-like.

ABL1_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.039105 (rank : 82)
Query Neighborhood Hits	69	Target Neighborhood Hits	1220	Shared Neighborhood Hits	49
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.039041 (rank : 83)
Query Neighborhood Hits	69	Target Neighborhood Hits	1178	Shared Neighborhood Hits	49
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CRKL_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.162051 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	50
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

RB40B_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.037404 (rank : 86)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q12829, Q8WVG3	Gene names	RAB40B, SEC4L
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Rar protein).

RB40B_MOUSE
θ value	1.38821 (rank : 47)	NC score	0.037872 (rank : 85)
Query Neighborhood Hits	69	Target Neighborhood Hits	265	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHP8	Gene names	Rab40b
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR).

SLAP2_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.098580 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	139	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

VAV3_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.115204 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ZN11B_HUMAN
θ value	1.38821 (rank : 50)	NC score	0.000317 (rank : 99)
Query Neighborhood Hits	69	Target Neighborhood Hits	802	Shared Neighborhood Hits	3
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

HSH2D_HUMAN
θ value	1.81305 (rank : 51)	NC score	0.148184 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	159	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ELL_MOUSE
θ value	2.36792 (rank : 52)	NC score	0.018900 (rank : 94)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

STAT1_MOUSE
θ value	2.36792 (rank : 53)	NC score	0.033460 (rank : 91)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	P42225	Gene names	Stat1
Domain Architecture
Description	Signal transducer and activator of transcription 1.

VAV3_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.115086 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ASB6_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.015984 (rank : 95)
Query Neighborhood Hits	69	Target Neighborhood Hits	264	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

SHC2_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.076661 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

VAV2_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.094488 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	49
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.093728 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	456	Shared Neighborhood Hits	49
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

STA5A_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.037208 (rank : 88)
Query Neighborhood Hits	69	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

STA5A_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.037276 (rank : 87)
Query Neighborhood Hits	69	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

STA5B_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.036890 (rank : 89)
Query Neighborhood Hits	69	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STA5B_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.036679 (rank : 90)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	18
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

FGR_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.038448 (rank : 84)
Query Neighborhood Hits	69	Target Neighborhood Hits	1069	Shared Neighborhood Hits	51
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MATK_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.033017 (rank : 92)
Query Neighborhood Hits	69	Target Neighborhood Hits	954	Shared Neighborhood Hits	49
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SHD_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.118793 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

STAT1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.030661 (rank : 93)
Query Neighborhood Hits	69	Target Neighborhood Hits	128	Shared Neighborhood Hits	14
SwissProt Accessions	P42224	Gene names	STAT1
Domain Architecture
Description	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84).

WSB2_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.010691 (rank : 96)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

WSB2_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.010659 (rank : 97)
Query Neighborhood Hits	69	Target Neighborhood Hits	306	Shared Neighborhood Hits	7
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

SHC2_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.070414 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

APS_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.050065 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	162	Shared Neighborhood Hits	30
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

GRAP2_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.066070 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	304	Shared Neighborhood Hits	39
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.064747 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	39
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.067470 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.068078 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	309	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.073721 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	39
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.075450 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	41
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

LCP2_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.061687 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	531	Shared Neighborhood Hits	30
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.078106 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.056970 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.062566 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

PTN6_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.051527 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.059677 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	258	Shared Neighborhood Hits	37
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.055542 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.091868 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.072103 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH23A_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.052788 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SH24A_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.055804 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	326	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SHB_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.122841 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.117275 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.066014 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.071201 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.086358 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.087027 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.109807 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.127997 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.135924 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	169	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.063507 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.067803 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

VAV_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.093208 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	430	Shared Neighborhood Hits	45
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

SOCS4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
NC score	0.997940 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS5_HUMAN
NC score	0.968078 (rank : 3)	θ value	4.4633e-116 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	91	Shared Neighborhood Hits	59
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
NC score	0.967102 (rank : 4)	θ value	2.2151e-115 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	93	Shared Neighborhood Hits	59
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SOCS6_HUMAN
NC score	0.700716 (rank : 5)	θ value	7.82807e-20 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	126	Shared Neighborhood Hits	52
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
NC score	0.698132 (rank : 6)	θ value	7.82807e-20 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS7_MOUSE
NC score	0.678511 (rank : 7)	θ value	1.29331e-14 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	154	Shared Neighborhood Hits	47
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOCS2_HUMAN
NC score	0.657042 (rank : 8)	θ value	1.2105e-12 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	104	Shared Neighborhood Hits	47
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

CISH_HUMAN
NC score	0.654315 (rank : 9)	θ value	3.18553e-13 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SOCS2_MOUSE
NC score	0.653383 (rank : 10)	θ value	6.00763e-12 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CISH_MOUSE
NC score	0.650980 (rank : 11)	θ value	1.58096e-12 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	46
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SOCS1_MOUSE
NC score	0.572750 (rank : 12)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS1_HUMAN
NC score	0.569669 (rank : 13)	θ value	1.29631e-06 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS3_HUMAN
NC score	0.529030 (rank : 14)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
NC score	0.521254 (rank : 15)	θ value	4.1701e-05 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

P55G_MOUSE
NC score	0.279929 (rank : 16)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	401	Shared Neighborhood Hits	53
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_HUMAN
NC score	0.277877 (rank : 17)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	451	Shared Neighborhood Hits	53
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.257776 (rank : 18)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P85B_HUMAN
NC score	0.247843 (rank : 19)	θ value	0.0193708 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	543	Shared Neighborhood Hits	54
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
NC score	0.247409 (rank : 20)	θ value	0.0330416 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	519	Shared Neighborhood Hits	54
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

DAPP1_HUMAN
NC score	0.242254 (rank : 21)	θ value	0.0148317 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	227	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P85A_MOUSE
NC score	0.236650 (rank : 22)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	435	Shared Neighborhood Hits	55
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_HUMAN
NC score	0.235306 (rank : 23)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	55
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CRK_HUMAN
NC score	0.208897 (rank : 24)	θ value	0.0148317 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	51
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.205916 (rank : 25)	θ value	0.0148317 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	51
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCK1_HUMAN
NC score	0.188020 (rank : 26)	θ value	0.00665767 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	45
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.179195 (rank : 27)	θ value	0.0193708 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	51
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

HSH2D_MOUSE
NC score	0.167331 (rank : 28)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CRKL_MOUSE
NC score	0.162051 (rank : 29)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	50
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.159454 (rank : 30)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	313	Shared Neighborhood Hits	49
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

HSH2D_HUMAN
NC score	0.148184 (rank : 31)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	159	Shared Neighborhood Hits	52
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PLCG1_HUMAN
NC score	0.141113 (rank : 32)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.139355 (rank : 33)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	314	Shared Neighborhood Hits	48
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SHE_MOUSE
NC score	0.135924 (rank : 34)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	69	Target Neighborhood Hits	169	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PLCG2_HUMAN
NC score	0.133700 (rank : 35)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	280	Shared Neighborhood Hits	43
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SHE_HUMAN
NC score	0.127997 (rank : 36)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	69	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_HUMAN
NC score	0.122841 (rank : 37)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	69	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_HUMAN
NC score	0.118793 (rank : 38)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	204	Shared Neighborhood Hits	45
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHB_MOUSE
NC score	0.117275 (rank : 39)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	69	Target Neighborhood Hits	137	Shared Neighborhood Hits	46
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

VAV3_HUMAN
NC score	0.115204 (rank : 40)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	398	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.115086 (rank : 41)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	404	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SH21B_MOUSE
NC score	0.114392 (rank : 42)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

VAV_HUMAN
NC score	0.110737 (rank : 43)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	46
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SHD_MOUSE
NC score	0.109807 (rank : 44)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	69	Target Neighborhood Hits	137	Shared Neighborhood Hits	43
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SLAP2_MOUSE
NC score	0.107443 (rank : 45)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	136	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.098580 (rank : 46)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	139	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

VAV2_HUMAN
NC score	0.094488 (rank : 47)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	453	Shared Neighborhood Hits	49
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.093728 (rank : 48)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	456	Shared Neighborhood Hits	49
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.093208 (rank : 49)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	69	Target Neighborhood Hits	430	Shared Neighborhood Hits	45
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SH22A_HUMAN
NC score	0.091868 (rank : 50)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	69	Target Neighborhood Hits	144	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SHC3_MOUSE
NC score	0.087027 (rank : 51)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC3_HUMAN
NC score	0.086358 (rank : 52)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	69	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

LCP2_MOUSE
NC score	0.078106 (rank : 53)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	177	Shared Neighborhood Hits	27
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

SHC2_MOUSE
NC score	0.076661 (rank : 54)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	144	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

GRB2_MOUSE
NC score	0.075450 (rank : 55)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	312	Shared Neighborhood Hits	41
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.073721 (rank : 56)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	310	Shared Neighborhood Hits	39
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH22A_MOUSE
NC score	0.072103 (rank : 57)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	69	Target Neighborhood Hits	179	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SHC1_MOUSE
NC score	0.071201 (rank : 58)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	69	Target Neighborhood Hits	180	Shared Neighborhood Hits	39
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
NC score	0.070414 (rank : 59)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	39
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

GRAP_MOUSE
NC score	0.068078 (rank : 60)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	309	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SLAP1_MOUSE
NC score	0.067803 (rank : 61)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	69	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

GRAP_HUMAN
NC score	0.067470 (rank : 62)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	307	Shared Neighborhood Hits	35
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP2_HUMAN
NC score	0.066070 (rank : 63)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	304	Shared Neighborhood Hits	39
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SHC1_HUMAN
NC score	0.066014 (rank : 64)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	37
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRAP2_MOUSE
NC score	0.064747 (rank : 65)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	297	Shared Neighborhood Hits	39
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SLAP1_HUMAN
NC score	0.063507 (rank : 66)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

LNK_MOUSE
NC score	0.062566 (rank : 67)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LCP2_HUMAN
NC score	0.061687 (rank : 68)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	531	Shared Neighborhood Hits	30
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CHIO_HUMAN
NC score	0.060260 (rank : 69)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	220	Shared Neighborhood Hits	36
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RASA1_HUMAN
NC score	0.059677 (rank : 70)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	69	Target Neighborhood Hits	258	Shared Neighborhood Hits	37
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

LNK_HUMAN
NC score	0.056970 (rank : 71)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH24A_MOUSE
NC score	0.055804 (rank : 72)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	69	Target Neighborhood Hits	326	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH21B_HUMAN
NC score	0.055542 (rank : 73)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	69	Target Neighborhood Hits	101	Shared Neighborhood Hits	23
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH23A_HUMAN
NC score	0.052788 (rank : 74)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	69	Target Neighborhood Hits	149	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

PTN6_MOUSE
NC score	0.051527 (rank : 75)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RB40A_HUMAN
NC score	0.050331 (rank : 76)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	267	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXH6, O00407, Q6DK06, Q8TF06	Gene names	RAB40A
Domain Architecture
Description	Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2).

APS_HUMAN
NC score	0.050065 (rank : 77)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	162	Shared Neighborhood Hits	30
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RB40C_MOUSE
NC score	0.048675 (rank : 78)	θ value	0.0736092 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHQ4	Gene names	Rab40c
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3).

RB40C_HUMAN
NC score	0.048645 (rank : 79)	θ value	0.0736092 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	262	Shared Neighborhood Hits	12
SwissProt Accessions	Q96S21, O60795, Q4TT41	Gene names	RAB40C, RARL, RASL8C
Domain Architecture
Description	Ras-related protein Rab-40C (SOCS box-containing protein RAR3) (Rar- like protein).

RB40L_HUMAN
NC score	0.042379 (rank : 80)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	264	Shared Neighborhood Hits	14
SwissProt Accessions	P0C0E4	Gene names	RAB40AL
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-40A-like.

ABL2_HUMAN
NC score	0.041914 (rank : 81)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	1045	Shared Neighborhood Hits	49
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ABL1_HUMAN
NC score	0.039105 (rank : 82)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	1220	Shared Neighborhood Hits	49
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.039041 (rank : 83)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	1178	Shared Neighborhood Hits	49
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FGR_MOUSE
NC score	0.038448 (rank : 84)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	1069	Shared Neighborhood Hits	51
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RB40B_MOUSE
NC score	0.037872 (rank : 85)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	265	Shared Neighborhood Hits	12
SwissProt Accessions	Q8VHP8	Gene names	Rab40b
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR).

RB40B_HUMAN
NC score	0.037404 (rank : 86)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	Q12829, Q8WVG3	Gene names	RAB40B, SEC4L
Domain Architecture
Description	Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Rar protein).

STA5A_MOUSE
NC score	0.037276 (rank : 87)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	128	Shared Neighborhood Hits	18
SwissProt Accessions	P42230	Gene names	Stat5a, Mgf, Mpf
Domain Architecture
Description	Signal transducer and activator of transcription 5A (Mammary gland factor).

STA5A_HUMAN
NC score	0.037208 (rank : 88)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P42229	Gene names	STAT5A, STAT5
Domain Architecture
Description	Signal transducer and activator of transcription 5A.

STA5B_HUMAN
NC score	0.036890 (rank : 89)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	103	Shared Neighborhood Hits	18
SwissProt Accessions	P51692, Q8WWS8	Gene names	STAT5B
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STA5B_MOUSE
NC score	0.036679 (rank : 90)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	124	Shared Neighborhood Hits	18
SwissProt Accessions	P42232, Q541Q5, Q60804, Q8K3Q1, Q9JKM1	Gene names	Stat5b
Domain Architecture
Description	Signal transducer and activator of transcription 5B.

STAT1_MOUSE
NC score	0.033460 (rank : 91)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	151	Shared Neighborhood Hits	14
SwissProt Accessions	P42225	Gene names	Stat1
Domain Architecture
Description	Signal transducer and activator of transcription 1.

MATK_HUMAN
NC score	0.033017 (rank : 92)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	954	Shared Neighborhood Hits	49
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

STAT1_HUMAN
NC score	0.030661 (rank : 93)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	128	Shared Neighborhood Hits	14
SwissProt Accessions	P42224	Gene names	STAT1
Domain Architecture
Description	Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84).

ELL_MOUSE
NC score	0.018900 (rank : 94)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

ASB6_MOUSE
NC score	0.015984 (rank : 95)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	264	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

WSB2_HUMAN
NC score	0.010691 (rank : 96)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	308	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYS7, Q9NRX9	Gene names	WSB2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein).

WSB2_MOUSE
NC score	0.010659 (rank : 97)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	306	Shared Neighborhood Hits	7
SwissProt Accessions	O54929, Q9R1M8	Gene names	Wsb2, Swip2
Domain Architecture
Description	WD repeat and SOCS box-containing protein 2 (WSB-2) (SOCS box- containing WD protein SWiP-2).

ZN33A_HUMAN
NC score	0.000684 (rank : 98)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	780	Shared Neighborhood Hits	3
SwissProt Accessions	Q06730, Q5VZ86	Gene names	ZNF33A, KIAA0065, KOX31, ZNF33
Domain Architecture
Description	Zinc finger protein 33A (Zinc finger protein KOX31) (Zinc finger and ZAK-associated protein with KRAB domain) (ZZaPK).

ZN11B_HUMAN
NC score	0.000317 (rank : 99)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	802	Shared Neighborhood Hits	3
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.