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Network neighborhood for query Sequence : SHC2_MOUSE

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SHC2_MOUSE
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SHC2_HUMAN
θ value	0 (rank : 1)	NC score	0.992630 (rank : 2)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	136
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC1_MOUSE
θ value	5.07123e-136 (rank : 3)	NC score	0.967326 (rank : 3)
Query Neighborhood Hits	144	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_HUMAN
θ value	4.29305e-135 (rank : 4)	NC score	0.966790 (rank : 4)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	124
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_MOUSE
θ value	3.5201e-129 (rank : 5)	NC score	0.962372 (rank : 5)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	122
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC3_HUMAN
θ value	3.89193e-128 (rank : 6)	NC score	0.955443 (rank : 6)
Query Neighborhood Hits	144	Target Neighborhood Hits	155	Shared Neighborhood Hits	118
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

FER_HUMAN
θ value	7.84624e-12 (rank : 7)	NC score	0.214536 (rank : 83)
Query Neighborhood Hits	144	Target Neighborhood Hits	1278	Shared Neighborhood Hits	123
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

BCAR3_HUMAN
θ value	2.13673e-09 (rank : 8)	NC score	0.529263 (rank : 11)
Query Neighborhood Hits	144	Target Neighborhood Hits	129	Shared Neighborhood Hits	91
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	2.13673e-09 (rank : 9)	NC score	0.528000 (rank : 12)
Query Neighborhood Hits	144	Target Neighborhood Hits	127	Shared Neighborhood Hits	90
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

APS_HUMAN
θ value	1.80886e-08 (rank : 10)	NC score	0.561739 (rank : 7)
Query Neighborhood Hits	144	Target Neighborhood Hits	162	Shared Neighborhood Hits	106
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

FES_HUMAN
θ value	8.97725e-08 (rank : 11)	NC score	0.176380 (rank : 113)
Query Neighborhood Hits	144	Target Neighborhood Hits	978	Shared Neighborhood Hits	92
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SH2D3_HUMAN
θ value	8.97725e-08 (rank : 12)	NC score	0.500796 (rank : 16)
Query Neighborhood Hits	144	Target Neighborhood Hits	188	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

LNK_MOUSE
θ value	1.17247e-07 (rank : 13)	NC score	0.544581 (rank : 8)
Query Neighborhood Hits	144	Target Neighborhood Hits	132	Shared Neighborhood Hits	103
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH2D3_MOUSE
θ value	1.17247e-07 (rank : 14)	NC score	0.502754 (rank : 15)
Query Neighborhood Hits	144	Target Neighborhood Hits	174	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

APS_MOUSE
θ value	3.41135e-07 (rank : 15)	NC score	0.511620 (rank : 13)
Query Neighborhood Hits	144	Target Neighborhood Hits	134	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SH23A_HUMAN
θ value	5.81887e-07 (rank : 16)	NC score	0.535343 (rank : 9)
Query Neighborhood Hits	144	Target Neighborhood Hits	149	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

FES_MOUSE
θ value	7.59969e-07 (rank : 17)	NC score	0.167254 (rank : 122)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	81
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GRB2_HUMAN
θ value	1.29631e-06 (rank : 18)	NC score	0.453917 (rank : 26)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	122
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	1.29631e-06 (rank : 19)	NC score	0.454242 (rank : 25)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	124
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_MOUSE
θ value	1.29631e-06 (rank : 20)	NC score	0.446055 (rank : 30)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	110
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_HUMAN
θ value	1.69304e-06 (rank : 21)	NC score	0.535066 (rank : 10)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SHD_HUMAN
θ value	1.69304e-06 (rank : 22)	NC score	0.492459 (rank : 17)
Query Neighborhood Hits	144	Target Neighborhood Hits	204	Shared Neighborhood Hits	111
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

GRB14_MOUSE
θ value	2.88788e-06 (rank : 23)	NC score	0.446570 (rank : 29)
Query Neighborhood Hits	144	Target Neighborhood Hits	149	Shared Neighborhood Hits	110
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

VAV_HUMAN
θ value	2.88788e-06 (rank : 24)	NC score	0.345220 (rank : 52)
Query Neighborhood Hits	144	Target Neighborhood Hits	452	Shared Neighborhood Hits	109
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

GRB14_HUMAN
θ value	8.40245e-06 (rank : 25)	NC score	0.442740 (rank : 33)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	110
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRAP_HUMAN
θ value	1.09739e-05 (rank : 26)	NC score	0.463441 (rank : 22)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	116
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ABL2_HUMAN
θ value	1.43324e-05 (rank : 27)	NC score	0.218071 (rank : 82)
Query Neighborhood Hits	144	Target Neighborhood Hits	1045	Shared Neighborhood Hits	126
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

NCK1_HUMAN
θ value	1.43324e-05 (rank : 28)	NC score	0.462525 (rank : 23)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	124
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRB7_HUMAN
θ value	1.87187e-05 (rank : 29)	NC score	0.425659 (rank : 36)
Query Neighborhood Hits	144	Target Neighborhood Hits	156	Shared Neighborhood Hits	109
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PLCG2_HUMAN
θ value	1.87187e-05 (rank : 30)	NC score	0.384210 (rank : 47)
Query Neighborhood Hits	144	Target Neighborhood Hits	280	Shared Neighborhood Hits	120
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV3_HUMAN
θ value	1.87187e-05 (rank : 31)	NC score	0.353023 (rank : 50)
Query Neighborhood Hits	144	Target Neighborhood Hits	398	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	1.87187e-05 (rank : 32)	NC score	0.352860 (rank : 51)
Query Neighborhood Hits	144	Target Neighborhood Hits	404	Shared Neighborhood Hits	113
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ANKS1_HUMAN
θ value	2.44474e-05 (rank : 33)	NC score	0.101069 (rank : 176)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	18
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	2.44474e-05 (rank : 34)	NC score	0.107106 (rank : 154)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

GRAP_MOUSE
θ value	2.44474e-05 (rank : 35)	NC score	0.458547 (rank : 24)
Query Neighborhood Hits	144	Target Neighborhood Hits	309	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PTN6_HUMAN
θ value	2.44474e-05 (rank : 36)	NC score	0.244718 (rank : 79)
Query Neighborhood Hits	144	Target Neighborhood Hits	234	Shared Neighborhood Hits	112
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

VAV_MOUSE
θ value	2.44474e-05 (rank : 37)	NC score	0.324010 (rank : 56)
Query Neighborhood Hits	144	Target Neighborhood Hits	430	Shared Neighborhood Hits	104
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CSK_MOUSE
θ value	3.19293e-05 (rank : 38)	NC score	0.210594 (rank : 86)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	121
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
θ value	4.1701e-05 (rank : 39)	NC score	0.209935 (rank : 87)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	121
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

GRB10_MOUSE
θ value	5.44631e-05 (rank : 40)	NC score	0.390321 (rank : 45)
Query Neighborhood Hits	144	Target Neighborhood Hits	156	Shared Neighborhood Hits	105
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

ABL1_HUMAN
θ value	7.1131e-05 (rank : 41)	NC score	0.212479 (rank : 84)
Query Neighborhood Hits	144	Target Neighborhood Hits	1220	Shared Neighborhood Hits	124
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	7.1131e-05 (rank : 42)	NC score	0.212104 (rank : 85)
Query Neighborhood Hits	144	Target Neighborhood Hits	1178	Shared Neighborhood Hits	124
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

GRB10_HUMAN
θ value	7.1131e-05 (rank : 43)	NC score	0.385230 (rank : 46)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	105
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

P85A_MOUSE
θ value	7.1131e-05 (rank : 44)	NC score	0.294813 (rank : 60)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	112
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHE_HUMAN
θ value	7.1131e-05 (rank : 45)	NC score	0.475914 (rank : 18)
Query Neighborhood Hits	144	Target Neighborhood Hits	164	Shared Neighborhood Hits	113
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PTN6_MOUSE
θ value	9.29e-05 (rank : 46)	NC score	0.248377 (rank : 77)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	118
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

P85A_HUMAN
θ value	0.000121331 (rank : 47)	NC score	0.289027 (rank : 63)
Query Neighborhood Hits	144	Target Neighborhood Hits	479	Shared Neighborhood Hits	111
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHB_HUMAN
θ value	0.000121331 (rank : 48)	NC score	0.464300 (rank : 21)
Query Neighborhood Hits	144	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	0.000121331 (rank : 49)	NC score	0.470373 (rank : 19)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
θ value	0.000121331 (rank : 50)	NC score	0.504575 (rank : 14)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	115
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SRC_HUMAN
θ value	0.000121331 (rank : 51)	NC score	0.205102 (rank : 91)
Query Neighborhood Hits	144	Target Neighborhood Hits	1058	Shared Neighborhood Hits	120
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	0.000121331 (rank : 52)	NC score	0.205988 (rank : 89)
Query Neighborhood Hits	144	Target Neighborhood Hits	1033	Shared Neighborhood Hits	120
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

CRK_HUMAN
θ value	0.00020696 (rank : 53)	NC score	0.448790 (rank : 27)
Query Neighborhood Hits	144	Target Neighborhood Hits	308	Shared Neighborhood Hits	122
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.00020696 (rank : 54)	NC score	0.444148 (rank : 32)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	122
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MATK_MOUSE
θ value	0.00020696 (rank : 55)	NC score	0.195642 (rank : 99)
Query Neighborhood Hits	144	Target Neighborhood Hits	952	Shared Neighborhood Hits	119
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

FRK_HUMAN
θ value	0.000270298 (rank : 56)	NC score	0.198421 (rank : 97)
Query Neighborhood Hits	144	Target Neighborhood Hits	1058	Shared Neighborhood Hits	121
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PTN11_HUMAN
θ value	0.000270298 (rank : 57)	NC score	0.279656 (rank : 68)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.000270298 (rank : 58)	NC score	0.279688 (rank : 67)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

SOCS2_HUMAN
θ value	0.000270298 (rank : 59)	NC score	0.299235 (rank : 59)
Query Neighborhood Hits	144	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

VAV2_MOUSE
θ value	0.000270298 (rank : 60)	NC score	0.326894 (rank : 54)
Query Neighborhood Hits	144	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

NCK2_HUMAN
θ value	0.000461057 (rank : 61)	NC score	0.447904 (rank : 28)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	128
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SHE_MOUSE
θ value	0.000461057 (rank : 62)	NC score	0.468160 (rank : 20)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FGR_MOUSE
θ value	0.000602161 (rank : 63)	NC score	0.218513 (rank : 81)
Query Neighborhood Hits	144	Target Neighborhood Hits	1069	Shared Neighborhood Hits	127
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MATK_HUMAN
θ value	0.000786445 (rank : 64)	NC score	0.196741 (rank : 98)
Query Neighborhood Hits	144	Target Neighborhood Hits	954	Shared Neighborhood Hits	122
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

SOCS2_MOUSE
θ value	0.000786445 (rank : 65)	NC score	0.293917 (rank : 61)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	74
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

GRAP2_HUMAN
θ value	0.00102713 (rank : 66)	NC score	0.405608 (rank : 40)
Query Neighborhood Hits	144	Target Neighborhood Hits	304	Shared Neighborhood Hits	111
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PTK6_MOUSE
θ value	0.00102713 (rank : 67)	NC score	0.182972 (rank : 104)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	113
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

BTK_HUMAN
θ value	0.00134147 (rank : 68)	NC score	0.178962 (rank : 110)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	100
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

FGR_HUMAN
θ value	0.00134147 (rank : 69)	NC score	0.208384 (rank : 88)
Query Neighborhood Hits	144	Target Neighborhood Hits	1067	Shared Neighborhood Hits	125
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

VAV2_HUMAN
θ value	0.00134147 (rank : 70)	NC score	0.326185 (rank : 55)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	113
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BTK_MOUSE
θ value	0.00175202 (rank : 71)	NC score	0.178850 (rank : 111)
Query Neighborhood Hits	144	Target Neighborhood Hits	1017	Shared Neighborhood Hits	100
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

YES_HUMAN
θ value	0.00175202 (rank : 72)	NC score	0.205658 (rank : 90)
Query Neighborhood Hits	144	Target Neighborhood Hits	1059	Shared Neighborhood Hits	114
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_HUMAN
θ value	0.00228821 (rank : 73)	NC score	0.199181 (rank : 96)
Query Neighborhood Hits	144	Target Neighborhood Hits	1078	Shared Neighborhood Hits	121
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.00228821 (rank : 74)	NC score	0.200463 (rank : 95)
Query Neighborhood Hits	144	Target Neighborhood Hits	1073	Shared Neighborhood Hits	118
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

RASA1_HUMAN
θ value	0.00228821 (rank : 75)	NC score	0.396234 (rank : 43)
Query Neighborhood Hits	144	Target Neighborhood Hits	258	Shared Neighborhood Hits	117
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21A_MOUSE
θ value	0.00228821 (rank : 76)	NC score	0.405820 (rank : 39)
Query Neighborhood Hits	144	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

CRKL_HUMAN
θ value	0.00298849 (rank : 77)	NC score	0.436656 (rank : 34)
Query Neighborhood Hits	144	Target Neighborhood Hits	313	Shared Neighborhood Hits	118
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

DAPP1_HUMAN
θ value	0.00298849 (rank : 78)	NC score	0.445949 (rank : 31)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLCG1_HUMAN
θ value	0.00298849 (rank : 79)	NC score	0.370615 (rank : 48)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	123
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH21A_HUMAN
θ value	0.00298849 (rank : 80)	NC score	0.402285 (rank : 42)
Query Neighborhood Hits	144	Target Neighborhood Hits	89	Shared Neighborhood Hits	82
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

YES_MOUSE
θ value	0.00298849 (rank : 81)	NC score	0.204528 (rank : 93)
Query Neighborhood Hits	144	Target Neighborhood Hits	1052	Shared Neighborhood Hits	114
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

GRAP2_MOUSE
θ value	0.00390308 (rank : 82)	NC score	0.395526 (rank : 44)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	111
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PLCG1_MOUSE
θ value	0.00509761 (rank : 83)	NC score	0.367488 (rank : 49)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	123
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRKL_MOUSE
θ value	0.00665767 (rank : 84)	NC score	0.433610 (rank : 35)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	118
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DAPP1_MOUSE
θ value	0.00665767 (rank : 85)	NC score	0.417929 (rank : 37)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LCP2_HUMAN
θ value	0.00665767 (rank : 86)	NC score	0.246416 (rank : 78)
Query Neighborhood Hits	144	Target Neighborhood Hits	531	Shared Neighborhood Hits	76
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CHIN_HUMAN
θ value	0.00869519 (rank : 87)	NC score	0.186910 (rank : 102)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	88
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

NUMB_HUMAN
θ value	0.00869519 (rank : 88)	NC score	0.110911 (rank : 147)
Query Neighborhood Hits	144	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	0.00869519 (rank : 89)	NC score	0.111218 (rank : 145)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

PTK6_HUMAN
θ value	0.00869519 (rank : 90)	NC score	0.179102 (rank : 109)
Query Neighborhood Hits	144	Target Neighborhood Hits	1020	Shared Neighborhood Hits	112
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TEC_HUMAN
θ value	0.00869519 (rank : 91)	NC score	0.165797 (rank : 125)
Query Neighborhood Hits	144	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

KSYK_HUMAN
θ value	0.0113563 (rank : 92)	NC score	0.177580 (rank : 112)
Query Neighborhood Hits	144	Target Neighborhood Hits	901	Shared Neighborhood Hits	114
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

ARH_HUMAN
θ value	0.0148317 (rank : 93)	NC score	0.130571 (rank : 136)
Query Neighborhood Hits	144	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

ITK_MOUSE
θ value	0.0148317 (rank : 94)	NC score	0.161938 (rank : 129)
Query Neighborhood Hits	144	Target Neighborhood Hits	985	Shared Neighborhood Hits	104
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LCP2_MOUSE
θ value	0.0148317 (rank : 95)	NC score	0.264891 (rank : 72)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CHIN_MOUSE
θ value	0.0193708 (rank : 96)	NC score	0.194852 (rank : 100)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	95
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

BLK_HUMAN
θ value	0.0252991 (rank : 97)	NC score	0.176148 (rank : 114)
Query Neighborhood Hits	144	Target Neighborhood Hits	994	Shared Neighborhood Hits	99
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_MOUSE
θ value	0.0563607 (rank : 98)	NC score	0.182711 (rank : 105)
Query Neighborhood Hits	144	Target Neighborhood Hits	1029	Shared Neighborhood Hits	105
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KSYK_MOUSE
θ value	0.0563607 (rank : 99)	NC score	0.173266 (rank : 118)
Query Neighborhood Hits	144	Target Neighborhood Hits	944	Shared Neighborhood Hits	116
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TEC_MOUSE
θ value	0.0563607 (rank : 100)	NC score	0.158863 (rank : 131)
Query Neighborhood Hits	144	Target Neighborhood Hits	1006	Shared Neighborhood Hits	94
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

SH21B_HUMAN
θ value	0.0736092 (rank : 101)	NC score	0.404206 (rank : 41)
Query Neighborhood Hits	144	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	0.0736092 (rank : 102)	NC score	0.408204 (rank : 38)
Query Neighborhood Hits	144	Target Neighborhood Hits	101	Shared Neighborhood Hits	91
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

HCK_HUMAN
θ value	0.0961366 (rank : 103)	NC score	0.182151 (rank : 106)
Query Neighborhood Hits	144	Target Neighborhood Hits	1035	Shared Neighborhood Hits	109
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BLK_MOUSE
θ value	0.125558 (rank : 104)	NC score	0.180665 (rank : 108)
Query Neighborhood Hits	144	Target Neighborhood Hits	992	Shared Neighborhood Hits	109
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMX_MOUSE
θ value	0.125558 (rank : 105)	NC score	0.165802 (rank : 124)
Query Neighborhood Hits	144	Target Neighborhood Hits	912	Shared Neighborhood Hits	101
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ITK_HUMAN
θ value	0.125558 (rank : 106)	NC score	0.162453 (rank : 127)
Query Neighborhood Hits	144	Target Neighborhood Hits	1016	Shared Neighborhood Hits	106
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BLNK_MOUSE
θ value	0.163984 (rank : 107)	NC score	0.203313 (rank : 94)
Query Neighborhood Hits	144	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BMX_HUMAN
θ value	0.163984 (rank : 108)	NC score	0.164857 (rank : 126)
Query Neighborhood Hits	144	Target Neighborhood Hits	942	Shared Neighborhood Hits	102
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SH24A_HUMAN
θ value	0.163984 (rank : 109)	NC score	0.269270 (rank : 69)
Query Neighborhood Hits	144	Target Neighborhood Hits	455	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

TXK_MOUSE
θ value	0.163984 (rank : 110)	NC score	0.169132 (rank : 121)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	113
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LYN_MOUSE
θ value	0.21417 (rank : 111)	NC score	0.175770 (rank : 115)
Query Neighborhood Hits	144	Target Neighborhood Hits	1023	Shared Neighborhood Hits	108
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

HSH2D_HUMAN
θ value	0.279714 (rank : 112)	NC score	0.332524 (rank : 53)
Query Neighborhood Hits	144	Target Neighborhood Hits	159	Shared Neighborhood Hits	108
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CHIO_HUMAN
θ value	0.365318 (rank : 113)	NC score	0.148961 (rank : 134)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	83
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

JIP1_MOUSE
θ value	0.365318 (rank : 114)	NC score	0.085670 (rank : 324)
Query Neighborhood Hits	144	Target Neighborhood Hits	259	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LCK_HUMAN
θ value	0.365318 (rank : 115)	NC score	0.182982 (rank : 103)
Query Neighborhood Hits	144	Target Neighborhood Hits	987	Shared Neighborhood Hits	109
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	0.365318 (rank : 116)	NC score	0.181436 (rank : 107)
Query Neighborhood Hits	144	Target Neighborhood Hits	981	Shared Neighborhood Hits	111
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

NUMBL_HUMAN
θ value	0.47712 (rank : 117)	NC score	0.078823 (rank : 356)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUMBL_MOUSE
θ value	0.47712 (rank : 118)	NC score	0.090590 (rank : 286)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	11
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

LYN_HUMAN
θ value	0.62314 (rank : 119)	NC score	0.173248 (rank : 119)
Query Neighborhood Hits	144	Target Neighborhood Hits	1022	Shared Neighborhood Hits	108
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SH24A_MOUSE
θ value	0.62314 (rank : 120)	NC score	0.252206 (rank : 76)
Query Neighborhood Hits	144	Target Neighborhood Hits	326	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

ZAP70_HUMAN
θ value	0.813845 (rank : 121)	NC score	0.152472 (rank : 133)
Query Neighborhood Hits	144	Target Neighborhood Hits	893	Shared Neighborhood Hits	111
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_MOUSE
θ value	0.813845 (rank : 122)	NC score	0.153841 (rank : 132)
Query Neighborhood Hits	144	Target Neighborhood Hits	905	Shared Neighborhood Hits	112
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

JIP1_HUMAN
θ value	1.06291 (rank : 123)	NC score	0.084066 (rank : 333)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LGR4_HUMAN
θ value	1.38821 (rank : 124)	NC score	0.001234 (rank : 533)
Query Neighborhood Hits	144	Target Neighborhood Hits	481	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

SETB1_MOUSE
θ value	1.38821 (rank : 125)	NC score	0.014417 (rank : 531)
Query Neighborhood Hits	144	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SOCS7_MOUSE
θ value	1.38821 (rank : 126)	NC score	0.190424 (rank : 101)
Query Neighborhood Hits	144	Target Neighborhood Hits	154	Shared Neighborhood Hits	79
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

HSH2D_MOUSE
θ value	1.81305 (rank : 127)	NC score	0.280368 (rank : 66)
Query Neighborhood Hits	144	Target Neighborhood Hits	124	Shared Neighborhood Hits	91
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH2D5_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.046834 (rank : 528)
Query Neighborhood Hits	144	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZV89, Q5SSJ2	Gene names	SH2D5
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 5.

TXK_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.160793 (rank : 130)
Query Neighborhood Hits	144	Target Neighborhood Hits	971	Shared Neighborhood Hits	106
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

JIP2_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.048785 (rank : 527)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

RPB1_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.016553 (rank : 529)
Query Neighborhood Hits	144	Target Neighborhood Hits	362	Shared Neighborhood Hits	5
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	2.36792 (rank : 132)	NC score	0.016526 (rank : 530)
Query Neighborhood Hits	144	Target Neighborhood Hits	363	Shared Neighborhood Hits	5
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

APBA3_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.079224 (rank : 354)
Query Neighborhood Hits	144	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

BLNK_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.173323 (rank : 117)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CISH_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.173487 (rank : 116)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

SPB11_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.002312 (rank : 532)
Query Neighborhood Hits	144	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q96P15, Q96P13, Q96P14	Gene names	SERPINB11
Domain Architecture
Description	Serpin B11.

CISH_MOUSE
θ value	4.03905 (rank : 137)	NC score	0.169560 (rank : 120)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

SH22A_MOUSE
θ value	4.03905 (rank : 138)	NC score	0.289668 (rank : 62)
Query Neighborhood Hits	144	Target Neighborhood Hits	179	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SOCS4_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.076661 (rank : 372)
Query Neighborhood Hits	144	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SH22A_HUMAN
θ value	5.27518 (rank : 140)	NC score	0.268213 (rank : 70)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SOCS4_MOUSE
θ value	5.27518 (rank : 141)	NC score	0.075832 (rank : 379)
Query Neighborhood Hits	144	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SLAP2_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.311664 (rank : 57)
Query Neighborhood Hits	144	Target Neighborhood Hits	139	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SOCS6_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.204690 (rank : 92)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.224076 (rank : 80)
Query Neighborhood Hits	144	Target Neighborhood Hits	146	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

AATK_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.097527 (rank : 213)
Query Neighborhood Hits	144	Target Neighborhood Hits	1243	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.101300 (rank : 174)
Query Neighborhood Hits	144	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

AB1IP_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.090263 (rank : 288)
Query Neighborhood Hits	144	Target Neighborhood Hits	213	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

AB1IP_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.089420 (rank : 298)
Query Neighborhood Hits	144	Target Neighborhood Hits	181	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

ABI1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.074319 (rank : 395)
Query Neighborhood Hits	144	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.077979 (rank : 360)
Query Neighborhood Hits	144	Target Neighborhood Hits	246	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.088756 (rank : 307)
Query Neighborhood Hits	144	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.088871 (rank : 304)
Query Neighborhood Hits	144	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.087235 (rank : 320)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.075811 (rank : 380)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ACK1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.105894 (rank : 164)
Query Neighborhood Hits	144	Target Neighborhood Hits	1140	Shared Neighborhood Hits	55
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.106331 (rank : 161)
Query Neighborhood Hits	144	Target Neighborhood Hits	1080	Shared Neighborhood Hits	55
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ACV1B_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.066649 (rank : 440)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.066731 (rank : 439)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1C_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.067097 (rank : 436)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.066808 (rank : 438)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACVL1_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.067578 (rank : 433)
Query Neighborhood Hits	144	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.067629 (rank : 432)
Query Neighborhood Hits	144	Target Neighborhood Hits	739	Shared Neighborhood Hits	43
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.062872 (rank : 453)
Query Neighborhood Hits	144	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.063279 (rank : 450)
Query Neighborhood Hits	144	Target Neighborhood Hits	768	Shared Neighborhood Hits	43
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AHI1_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.090766 (rank : 281)
Query Neighborhood Hits	144	Target Neighborhood Hits	537	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.088405 (rank : 311)
Query Neighborhood Hits	144	Target Neighborhood Hits	496	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AL2S2_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.050320 (rank : 517)
Query Neighborhood Hits	144	Target Neighborhood Hits	727	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AL2S2_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.051760 (rank : 502)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2S7_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.050916 (rank : 510)
Query Neighborhood Hits	144	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ALK_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.105362 (rank : 167)
Query Neighborhood Hits	144	Target Neighborhood Hits	795	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.105710 (rank : 165)
Query Neighborhood Hits	144	Target Neighborhood Hits	811	Shared Neighborhood Hits	43
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMHR2_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.061952 (rank : 455)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ANKK1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.064964 (rank : 443)
Query Neighborhood Hits	144	Target Neighborhood Hits	1075	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.065400 (rank : 442)
Query Neighborhood Hits	144	Target Neighborhood Hits	1072	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANM2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.080519 (rank : 346)
Query Neighborhood Hits	144	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.075174 (rank : 385)
Query Neighborhood Hits	144	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.085425 (rank : 326)
Query Neighborhood Hits	144	Target Neighborhood Hits	612	Shared Neighborhood Hits	43
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.085353 (rank : 327)
Query Neighborhood Hits	144	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.079812 (rank : 350)
Query Neighborhood Hits	144	Target Neighborhood Hits	646	Shared Neighborhood Hits	43
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.080193 (rank : 347)
Query Neighborhood Hits	144	Target Neighborhood Hits	607	Shared Neighborhood Hits	43
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APBA1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.068485 (rank : 422)
Query Neighborhood Hits	144	Target Neighborhood Hits	325	Shared Neighborhood Hits	10
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

APBA2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.071988 (rank : 409)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.068051 (rank : 428)
Query Neighborhood Hits	144	Target Neighborhood Hits	219	Shared Neighborhood Hits	11
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA3_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.056495 (rank : 471)
Query Neighborhood Hits	144	Target Neighborhood Hits	201	Shared Neighborhood Hits	10
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

ARAF_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.081364 (rank : 343)
Query Neighborhood Hits	144	Target Neighborhood Hits	924	Shared Neighborhood Hits	51
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.081522 (rank : 342)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG4_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.078653 (rank : 357)
Query Neighborhood Hits	144	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.058884 (rank : 461)
Query Neighborhood Hits	144	Target Neighborhood Hits	185	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG6_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.098576 (rank : 197)
Query Neighborhood Hits	144	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.092738 (rank : 265)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.099216 (rank : 195)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	51
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.099858 (rank : 187)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG9_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.063906 (rank : 448)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	37
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.063865 (rank : 449)
Query Neighborhood Hits	144	Target Neighborhood Hits	234	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARH_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.059543 (rank : 457)
Query Neighborhood Hits	144	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

ASPP1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.053439 (rank : 487)
Query Neighborhood Hits	144	Target Neighborhood Hits	956	Shared Neighborhood Hits	39
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.050769 (rank : 511)
Query Neighborhood Hits	144	Target Neighborhood Hits	1244	Shared Neighborhood Hits	43
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

AVR2A_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.051201 (rank : 508)
Query Neighborhood Hits	144	Target Neighborhood Hits	767	Shared Neighborhood Hits	43
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.051203 (rank : 507)
Query Neighborhood Hits	144	Target Neighborhood Hits	767	Shared Neighborhood Hits	43
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.050158 (rank : 522)
Query Neighborhood Hits	144	Target Neighborhood Hits	748	Shared Neighborhood Hits	43
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.050002 (rank : 526)
Query Neighborhood Hits	144	Target Neighborhood Hits	749	Shared Neighborhood Hits	43
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BCAR1_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.054407 (rank : 477)
Query Neighborhood Hits	144	Target Neighborhood Hits	554	Shared Neighborhood Hits	51
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.057100 (rank : 464)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	51
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BMPR2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.057890 (rank : 462)
Query Neighborhood Hits	144	Target Neighborhood Hits	736	Shared Neighborhood Hits	43
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.057847 (rank : 463)
Query Neighborhood Hits	144	Target Neighborhood Hits	738	Shared Neighborhood Hits	43
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1A_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.072927 (rank : 404)
Query Neighborhood Hits	144	Target Neighborhood Hits	759	Shared Neighborhood Hits	43
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.073016 (rank : 402)
Query Neighborhood Hits	144	Target Neighborhood Hits	758	Shared Neighborhood Hits	43
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BMR1B_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.074964 (rank : 388)
Query Neighborhood Hits	144	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.074840 (rank : 391)
Query Neighborhood Hits	144	Target Neighborhood Hits	758	Shared Neighborhood Hits	43
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BRAF1_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.082406 (rank : 339)
Query Neighborhood Hits	144	Target Neighborhood Hits	883	Shared Neighborhood Hits	52
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CD2AP_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.110961 (rank : 146)
Query Neighborhood Hits	144	Target Neighborhood Hits	315	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 212)	NC score	0.105426 (rank : 166)
Query Neighborhood Hits	144	Target Neighborhood Hits	336	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CI096_HUMAN
θ value	θ > 10 (rank : 213)	NC score	0.057035 (rank : 465)
Query Neighborhood Hits	144	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CIP4_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.085061 (rank : 329)
Query Neighborhood Hits	144	Target Neighborhood Hits	374	Shared Neighborhood Hits	38
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CSF1R_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.098447 (rank : 198)
Query Neighborhood Hits	144	Target Neighborhood Hits	943	Shared Neighborhood Hits	43
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 216)	NC score	0.095890 (rank : 233)
Query Neighborhood Hits	144	Target Neighborhood Hits	983	Shared Neighborhood Hits	43
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CT032_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.053779 (rank : 479)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.075989 (rank : 377)
Query Neighborhood Hits	144	Target Neighborhood Hits	244	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 219)	NC score	0.074932 (rank : 390)
Query Neighborhood Hits	144	Target Neighborhood Hits	306	Shared Neighborhood Hits	45
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDR1_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.100211 (rank : 182)
Query Neighborhood Hits	144	Target Neighborhood Hits	819	Shared Neighborhood Hits	43
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.100450 (rank : 178)
Query Neighborhood Hits	144	Target Neighborhood Hits	818	Shared Neighborhood Hits	43
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.096459 (rank : 222)
Query Neighborhood Hits	144	Target Neighborhood Hits	818	Shared Neighborhood Hits	43
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.096353 (rank : 227)
Query Neighborhood Hits	144	Target Neighborhood Hits	813	Shared Neighborhood Hits	43
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DNMBP_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.106103 (rank : 162)
Query Neighborhood Hits	144	Target Neighborhood Hits	413	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.100409 (rank : 180)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

E2AK2_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.052033 (rank : 498)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

EFS_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.052478 (rank : 495)
Query Neighborhood Hits	144	Target Neighborhood Hits	348	Shared Neighborhood Hits	41
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.056140 (rank : 474)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	44
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.095309 (rank : 241)
Query Neighborhood Hits	144	Target Neighborhood Hits	939	Shared Neighborhood Hits	43
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.095294 (rank : 242)
Query Neighborhood Hits	144	Target Neighborhood Hits	927	Shared Neighborhood Hits	43
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA1_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.096068 (rank : 231)
Query Neighborhood Hits	144	Target Neighborhood Hits	997	Shared Neighborhood Hits	45
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.097085 (rank : 218)
Query Neighborhood Hits	144	Target Neighborhood Hits	958	Shared Neighborhood Hits	45
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.094725 (rank : 246)
Query Neighborhood Hits	144	Target Neighborhood Hits	1021	Shared Neighborhood Hits	45
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.094702 (rank : 248)
Query Neighborhood Hits	144	Target Neighborhood Hits	1020	Shared Neighborhood Hits	45
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.090757 (rank : 282)
Query Neighborhood Hits	144	Target Neighborhood Hits	1005	Shared Neighborhood Hits	43
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.091014 (rank : 278)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	43
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.092714 (rank : 266)
Query Neighborhood Hits	144	Target Neighborhood Hits	975	Shared Neighborhood Hits	45
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.092752 (rank : 264)
Query Neighborhood Hits	144	Target Neighborhood Hits	982	Shared Neighborhood Hits	45
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.092584 (rank : 267)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.096393 (rank : 223)
Query Neighborhood Hits	144	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.097683 (rank : 210)
Query Neighborhood Hits	144	Target Neighborhood Hits	959	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 242)	NC score	0.097488 (rank : 216)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.091398 (rank : 276)
Query Neighborhood Hits	144	Target Neighborhood Hits	1053	Shared Neighborhood Hits	45
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.091265 (rank : 277)
Query Neighborhood Hits	144	Target Neighborhood Hits	1025	Shared Neighborhood Hits	45
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.093749 (rank : 257)
Query Neighborhood Hits	144	Target Neighborhood Hits	956	Shared Neighborhood Hits	47
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.094053 (rank : 255)
Query Neighborhood Hits	144	Target Neighborhood Hits	969	Shared Neighborhood Hits	47
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.101173 (rank : 175)
Query Neighborhood Hits	144	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.091694 (rank : 273)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.093243 (rank : 260)
Query Neighborhood Hits	144	Target Neighborhood Hits	983	Shared Neighborhood Hits	45
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.093166 (rank : 261)
Query Neighborhood Hits	144	Target Neighborhood Hits	982	Shared Neighborhood Hits	45
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.094113 (rank : 254)
Query Neighborhood Hits	144	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.094124 (rank : 253)
Query Neighborhood Hits	144	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.093468 (rank : 258)
Query Neighborhood Hits	144	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.093060 (rank : 262)
Query Neighborhood Hits	144	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.099664 (rank : 188)
Query Neighborhood Hits	144	Target Neighborhood Hits	912	Shared Neighborhood Hits	46
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.098952 (rank : 196)
Query Neighborhood Hits	144	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPS8_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.064851 (rank : 444)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.065936 (rank : 441)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	44
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ERBB2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.097988 (rank : 206)
Query Neighborhood Hits	144	Target Neighborhood Hits	1073	Shared Neighborhood Hits	44
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.098161 (rank : 203)
Query Neighborhood Hits	144	Target Neighborhood Hits	918	Shared Neighborhood Hits	43
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.098211 (rank : 202)
Query Neighborhood Hits	144	Target Neighborhood Hits	918	Shared Neighborhood Hits	43
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.097961 (rank : 207)
Query Neighborhood Hits	144	Target Neighborhood Hits	898	Shared Neighborhood Hits	43
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.097503 (rank : 215)
Query Neighborhood Hits	144	Target Neighborhood Hits	910	Shared Neighborhood Hits	43
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.077232 (rank : 366)
Query Neighborhood Hits	144	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.064051 (rank : 447)
Query Neighborhood Hits	144	Target Neighborhood Hits	143	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.075862 (rank : 378)
Query Neighborhood Hits	144	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.075710 (rank : 381)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.089737 (rank : 293)
Query Neighborhood Hits	144	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.085178 (rank : 328)
Query Neighborhood Hits	144	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FAK1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.097476 (rank : 217)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.097514 (rank : 214)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.101587 (rank : 173)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.100889 (rank : 177)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FGFR1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.088575 (rank : 310)
Query Neighborhood Hits	144	Target Neighborhood Hits	1069	Shared Neighborhood Hits	43
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.088587 (rank : 309)
Query Neighborhood Hits	144	Target Neighborhood Hits	1068	Shared Neighborhood Hits	43
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.088819 (rank : 305)
Query Neighborhood Hits	144	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.089220 (rank : 301)
Query Neighborhood Hits	144	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.089830 (rank : 292)
Query Neighborhood Hits	144	Target Neighborhood Hits	1042	Shared Neighborhood Hits	43
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.089370 (rank : 299)
Query Neighborhood Hits	144	Target Neighborhood Hits	1059	Shared Neighborhood Hits	43
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.091982 (rank : 270)
Query Neighborhood Hits	144	Target Neighborhood Hits	1037	Shared Neighborhood Hits	43
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.093755 (rank : 256)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FLT3_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.099261 (rank : 194)
Query Neighborhood Hits	144	Target Neighborhood Hits	843	Shared Neighborhood Hits	43
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.099959 (rank : 184)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FNBP2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.071154 (rank : 412)
Query Neighborhood Hits	144	Target Neighborhood Hits	432	Shared Neighborhood Hits	52
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GUC2C_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.084191 (rank : 331)
Query Neighborhood Hits	144	Target Neighborhood Hits	624	Shared Neighborhood Hits	43
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

GUC2D_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.075702 (rank : 382)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.076145 (rank : 375)
Query Neighborhood Hits	144	Target Neighborhood Hits	692	Shared Neighborhood Hits	43
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.087446 (rank : 318)
Query Neighborhood Hits	144	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.077143 (rank : 370)
Query Neighborhood Hits	144	Target Neighborhood Hits	644	Shared Neighborhood Hits	40
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCLS1_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.089606 (rank : 294)
Query Neighborhood Hits	144	Target Neighborhood Hits	358	Shared Neighborhood Hits	46
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.088143 (rank : 314)
Query Neighborhood Hits	144	Target Neighborhood Hits	329	Shared Neighborhood Hits	47
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.064494 (rank : 445)
Query Neighborhood Hits	144	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.059313 (rank : 460)
Query Neighborhood Hits	144	Target Neighborhood Hits	1024	Shared Neighborhood Hits	54
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ICK_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.050218 (rank : 519)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.050308 (rank : 518)
Query Neighborhood Hits	144	Target Neighborhood Hits	860	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

IGF1R_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.099404 (rank : 193)
Query Neighborhood Hits	144	Target Neighborhood Hits	977	Shared Neighborhood Hits	43
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.099435 (rank : 192)
Query Neighborhood Hits	144	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IKKA_HUMAN
θ value	θ > 10 (rank : 298)	NC score	0.051370 (rank : 504)
Query Neighborhood Hits	144	Target Neighborhood Hits	863	Shared Neighborhood Hits	43
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 299)	NC score	0.050626 (rank : 513)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

ILK1_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.088016 (rank : 316)
Query Neighborhood Hits	144	Target Neighborhood Hits	857	Shared Neighborhood Hits	45
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.087244 (rank : 319)
Query Neighborhood Hits	144	Target Neighborhood Hits	848	Shared Neighborhood Hits	45
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.088926 (rank : 303)
Query Neighborhood Hits	144	Target Neighborhood Hits	858	Shared Neighborhood Hits	45
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INSRR_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.098144 (rank : 204)
Query Neighborhood Hits	144	Target Neighborhood Hits	950	Shared Neighborhood Hits	43
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.098043 (rank : 205)
Query Neighborhood Hits	144	Target Neighborhood Hits	961	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.096843 (rank : 219)
Query Neighborhood Hits	144	Target Neighborhood Hits	963	Shared Neighborhood Hits	43
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.096356 (rank : 226)
Query Neighborhood Hits	144	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK1_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.073533 (rank : 399)
Query Neighborhood Hits	144	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.077938 (rank : 362)
Query Neighborhood Hits	144	Target Neighborhood Hits	784	Shared Neighborhood Hits	45
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK2_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.067058 (rank : 437)
Query Neighborhood Hits	144	Target Neighborhood Hits	714	Shared Neighborhood Hits	40
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

IRAK3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.077216 (rank : 367)
Query Neighborhood Hits	144	Target Neighborhood Hits	644	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.079288 (rank : 353)
Query Neighborhood Hits	144	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK4_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.070704 (rank : 413)
Query Neighborhood Hits	144	Target Neighborhood Hits	816	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRAK4_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.068493 (rank : 421)
Query Neighborhood Hits	144	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITSN1_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.075075 (rank : 386)
Query Neighborhood Hits	144	Target Neighborhood Hits	1757	Shared Neighborhood Hits	66
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.074521 (rank : 394)
Query Neighborhood Hits	144	Target Neighborhood Hits	1669	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.082843 (rank : 337)
Query Neighborhood Hits	144	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.077936 (rank : 363)
Query Neighborhood Hits	144	Target Neighborhood Hits	1371	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JAK1_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.088790 (rank : 306)
Query Neighborhood Hits	144	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.089867 (rank : 290)
Query Neighborhood Hits	144	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK2_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.082949 (rank : 336)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.083707 (rank : 335)
Query Neighborhood Hits	144	Target Neighborhood Hits	839	Shared Neighborhood Hits	46
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.085637 (rank : 325)
Query Neighborhood Hits	144	Target Neighborhood Hits	827	Shared Neighborhood Hits	43
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JAK3_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.082424 (rank : 338)
Query Neighborhood Hits	144	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KC1D_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.055830 (rank : 475)
Query Neighborhood Hits	144	Target Neighborhood Hits	737	Shared Neighborhood Hits	41
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.055829 (rank : 476)
Query Neighborhood Hits	144	Target Neighborhood Hits	737	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.053691 (rank : 481)
Query Neighborhood Hits	144	Target Neighborhood Hits	732	Shared Neighborhood Hits	41
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.053693 (rank : 480)
Query Neighborhood Hits	144	Target Neighborhood Hits	728	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KIT_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.095791 (rank : 235)
Query Neighborhood Hits	144	Target Neighborhood Hits	953	Shared Neighborhood Hits	43
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.096370 (rank : 225)
Query Neighborhood Hits	144	Target Neighborhood Hits	949	Shared Neighborhood Hits	43
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KPCB_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.050022 (rank : 525)
Query Neighborhood Hits	144	Target Neighborhood Hits	1121	Shared Neighborhood Hits	54
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.050436 (rank : 515)
Query Neighborhood Hits	144	Target Neighborhood Hits	1117	Shared Neighborhood Hits	54
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCD_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.051714 (rank : 503)
Query Neighborhood Hits	144	Target Neighborhood Hits	900	Shared Neighborhood Hits	52
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.051120 (rank : 509)
Query Neighborhood Hits	144	Target Neighborhood Hits	888	Shared Neighborhood Hits	52
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCT_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.050668 (rank : 512)
Query Neighborhood Hits	144	Target Neighborhood Hits	897	Shared Neighborhood Hits	52
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KSR1_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.077184 (rank : 369)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.076349 (rank : 373)
Query Neighborhood Hits	144	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

KSR2_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.077407 (rank : 365)
Query Neighborhood Hits	144	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LASP1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.078620 (rank : 358)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.077618 (rank : 364)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LIMK1_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.070083 (rank : 416)
Query Neighborhood Hits	144	Target Neighborhood Hits	1005	Shared Neighborhood Hits	44
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
θ value	θ > 10 (rank : 341)	NC score	0.070084 (rank : 415)
Query Neighborhood Hits	144	Target Neighborhood Hits	1008	Shared Neighborhood Hits	44
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK2_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.068186 (rank : 426)
Query Neighborhood Hits	144	Target Neighborhood Hits	986	Shared Neighborhood Hits	43
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 343)	NC score	0.068191 (rank : 425)
Query Neighborhood Hits	144	Target Neighborhood Hits	998	Shared Neighborhood Hits	43
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.063029 (rank : 452)
Query Neighborhood Hits	144	Target Neighborhood Hits	1237	Shared Neighborhood Hits	46
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.063067 (rank : 451)
Query Neighborhood Hits	144	Target Neighborhood Hits	1267	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK2_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.059934 (rank : 456)
Query Neighborhood Hits	144	Target Neighborhood Hits	1382	Shared Neighborhood Hits	44
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK2_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.059388 (rank : 458)
Query Neighborhood Hits	144	Target Neighborhood Hits	1359	Shared Neighborhood Hits	44
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

LTK_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.107097 (rank : 155)
Query Neighborhood Hits	144	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.105981 (rank : 163)
Query Neighborhood Hits	144	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K10_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.091453 (rank : 275)
Query Neighborhood Hits	144	Target Neighborhood Hits	1071	Shared Neighborhood Hits	64
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K11_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.095506 (rank : 239)
Query Neighborhood Hits	144	Target Neighborhood Hits	1136	Shared Neighborhood Hits	65
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K12_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.074970 (rank : 387)
Query Neighborhood Hits	144	Target Neighborhood Hits	940	Shared Neighborhood Hits	43
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.074963 (rank : 389)
Query Neighborhood Hits	144	Target Neighborhood Hits	957	Shared Neighborhood Hits	44
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K13_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.074801 (rank : 392)
Query Neighborhood Hits	144	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K7_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.073007 (rank : 403)
Query Neighborhood Hits	144	Target Neighborhood Hits	892	Shared Neighborhood Hits	45
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.073041 (rank : 401)
Query Neighborhood Hits	144	Target Neighborhood Hits	892	Shared Neighborhood Hits	45
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K9_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.092078 (rank : 269)
Query Neighborhood Hits	144	Target Neighborhood Hits	1123	Shared Neighborhood Hits	65
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.096387 (rank : 224)
Query Neighborhood Hits	144	Target Neighborhood Hits	1087	Shared Neighborhood Hits	65
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAK_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.050056 (rank : 524)
Query Neighborhood Hits	144	Target Neighborhood Hits	873	Shared Neighborhood Hits	43
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MERTK_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.099899 (rank : 186)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.099471 (rank : 191)
Query Neighborhood Hits	144	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.094992 (rank : 244)
Query Neighborhood Hits	144	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.095517 (rank : 238)
Query Neighborhood Hits	144	Target Neighborhood Hits	844	Shared Neighborhood Hits	43
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.090602 (rank : 285)
Query Neighborhood Hits	144	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.088993 (rank : 302)
Query Neighborhood Hits	144	Target Neighborhood Hits	707	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLTK_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.079734 (rank : 351)
Query Neighborhood Hits	144	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.079693 (rank : 352)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.078503 (rank : 359)
Query Neighborhood Hits	144	Target Neighborhood Hits	829	Shared Neighborhood Hits	43
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.077194 (rank : 368)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MP2K2_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.051309 (rank : 506)
Query Neighborhood Hits	144	Target Neighborhood Hits	830	Shared Neighborhood Hits	43
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.051364 (rank : 505)
Query Neighborhood Hits	144	Target Neighborhood Hits	828	Shared Neighborhood Hits	43
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K5_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.051921 (rank : 500)
Query Neighborhood Hits	144	Target Neighborhood Hits	840	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.050548 (rank : 514)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.053465 (rank : 485)
Query Neighborhood Hits	144	Target Neighborhood Hits	852	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.053354 (rank : 488)
Query Neighborhood Hits	144	Target Neighborhood Hits	860	Shared Neighborhood Hits	43
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MUSK_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.090633 (rank : 284)
Query Neighborhood Hits	144	Target Neighborhood Hits	1074	Shared Neighborhood Hits	43
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.090941 (rank : 279)
Query Neighborhood Hits	144	Target Neighborhood Hits	1057	Shared Neighborhood Hits	43
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYLK2_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.051873 (rank : 501)
Query Neighborhood Hits	144	Target Neighborhood Hits	920	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NCF1_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.096195 (rank : 229)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.094799 (rank : 245)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.097915 (rank : 208)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.062294 (rank : 454)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	31
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBL_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.076226 (rank : 374)
Query Neighborhood Hits	144	Target Neighborhood Hits	457	Shared Neighborhood Hits	49
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 384)	NC score	0.059365 (rank : 459)
Query Neighborhood Hits	144	Target Neighborhood Hits	420	Shared Neighborhood Hits	46
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NEK11_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.056260 (rank : 473)
Query Neighborhood Hits	144	Target Neighborhood Hits	1043	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.057003 (rank : 467)
Query Neighborhood Hits	144	Target Neighborhood Hits	875	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK4_MOUSE
θ value	θ > 10 (rank : 387)	NC score	0.050394 (rank : 516)
Query Neighborhood Hits	144	Target Neighborhood Hits	899	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK6_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.053152 (rank : 491)
Query Neighborhood Hits	144	Target Neighborhood Hits	848	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.053286 (rank : 490)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.052810 (rank : 493)
Query Neighborhood Hits	144	Target Neighborhood Hits	846	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.052640 (rank : 494)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NOXO1_MOUSE
θ value	θ > 10 (rank : 392)	NC score	0.057031 (rank : 466)
Query Neighborhood Hits	144	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.124409 (rank : 137)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	55
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.137410 (rank : 135)
Query Neighborhood Hits	144	Target Neighborhood Hits	267	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTRK1_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.098435 (rank : 199)
Query Neighborhood Hits	144	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.091842 (rank : 272)
Query Neighborhood Hits	144	Target Neighborhood Hits	1081	Shared Neighborhood Hits	43
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.091847 (rank : 271)
Query Neighborhood Hits	144	Target Neighborhood Hits	1088	Shared Neighborhood Hits	43
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 398)	NC score	0.095620 (rank : 237)
Query Neighborhood Hits	144	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

OSTF1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.107761 (rank : 151)
Query Neighborhood Hits	144	Target Neighborhood Hits	466	Shared Neighborhood Hits	54
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.102759 (rank : 170)
Query Neighborhood Hits	144	Target Neighborhood Hits	467	Shared Neighborhood Hits	54
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OXSR1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.056449 (rank : 472)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.056536 (rank : 470)
Query Neighborhood Hits	144	Target Neighborhood Hits	865	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

P55G_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.264231 (rank : 74)
Query Neighborhood Hits	144	Target Neighborhood Hits	451	Shared Neighborhood Hits	105
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.255912 (rank : 75)
Query Neighborhood Hits	144	Target Neighborhood Hits	401	Shared Neighborhood Hits	102
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.268006 (rank : 71)
Query Neighborhood Hits	144	Target Neighborhood Hits	543	Shared Neighborhood Hits	114
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.264435 (rank : 73)
Query Neighborhood Hits	144	Target Neighborhood Hits	519	Shared Neighborhood Hits	113
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACN1_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.093412 (rank : 259)
Query Neighborhood Hits	144	Target Neighborhood Hits	320	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.092161 (rank : 268)
Query Neighborhood Hits	144	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.094210 (rank : 252)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.091532 (rank : 274)
Query Neighborhood Hits	144	Target Neighborhood Hits	382	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.088192 (rank : 313)
Query Neighborhood Hits	144	Target Neighborhood Hits	385	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.090149 (rank : 289)
Query Neighborhood Hits	144	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.074537 (rank : 393)
Query Neighborhood Hits	144	Target Neighborhood Hits	128	Shared Neighborhood Hits	30
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 414)	NC score	0.067208 (rank : 435)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PGFRA_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.095717 (rank : 236)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	43
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.095956 (rank : 232)
Query Neighborhood Hits	144	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.096208 (rank : 228)
Query Neighborhood Hits	144	Target Neighborhood Hits	962	Shared Neighborhood Hits	43
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.096146 (rank : 230)
Query Neighborhood Hits	144	Target Neighborhood Hits	960	Shared Neighborhood Hits	43
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PPIP1_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.102510 (rank : 171)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	58
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.100413 (rank : 179)
Query Neighborhood Hits	144	Target Neighborhood Hits	377	Shared Neighborhood Hits	56
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PTK7_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.087575 (rank : 317)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	43
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

RAF1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.081748 (rank : 340)
Query Neighborhood Hits	144	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 423)	NC score	0.081316 (rank : 344)
Query Neighborhood Hits	144	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAPH1_HUMAN
θ value	θ > 10 (rank : 424)	NC score	0.072089 (rank : 407)
Query Neighborhood Hits	144	Target Neighborhood Hits	593	Shared Neighborhood Hits	16
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

RET_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.095818 (rank : 234)
Query Neighborhood Hits	144	Target Neighborhood Hits	873	Shared Neighborhood Hits	43
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.095087 (rank : 243)
Query Neighborhood Hits	144	Target Neighborhood Hits	884	Shared Neighborhood Hits	43
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RHG04_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.081093 (rank : 345)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RHG26_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.052975 (rank : 492)
Query Neighborhood Hits	144	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

RIPK1_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.076936 (rank : 371)
Query Neighborhood Hits	144	Target Neighborhood Hits	891	Shared Neighborhood Hits	43
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.077942 (rank : 361)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK2_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.072425 (rank : 405)
Query Neighborhood Hits	144	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.073997 (rank : 396)
Query Neighborhood Hits	144	Target Neighborhood Hits	776	Shared Neighborhood Hits	43
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.072240 (rank : 406)
Query Neighborhood Hits	144	Target Neighborhood Hits	828	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.073106 (rank : 400)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK4_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.064472 (rank : 446)
Query Neighborhood Hits	144	Target Neighborhood Hits	1094	Shared Neighborhood Hits	45
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RIPK5_HUMAN
θ value	θ > 10 (rank : 436)	NC score	0.068196 (rank : 424)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 437)	NC score	0.068100 (rank : 427)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RON_HUMAN
θ value	θ > 10 (rank : 438)	NC score	0.096488 (rank : 221)
Query Neighborhood Hits	144	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 439)	NC score	0.098331 (rank : 201)
Query Neighborhood Hits	144	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 440)	NC score	0.094526 (rank : 250)
Query Neighborhood Hits	144	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.094723 (rank : 247)
Query Neighborhood Hits	144	Target Neighborhood Hits	1025	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.095410 (rank : 240)
Query Neighborhood Hits	144	Target Neighborhood Hits	1014	Shared Neighborhood Hits	43
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.097665 (rank : 212)
Query Neighborhood Hits	144	Target Neighborhood Hits	1000	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.103595 (rank : 169)
Query Neighborhood Hits	144	Target Neighborhood Hits	907	Shared Neighborhood Hits	43
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RUSC1_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.053605 (rank : 483)
Query Neighborhood Hits	144	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RYK_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.107480 (rank : 153)
Query Neighborhood Hits	144	Target Neighborhood Hits	701	Shared Neighborhood Hits	43
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.106620 (rank : 158)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SH3G1_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.073985 (rank : 398)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.076124 (rank : 376)
Query Neighborhood Hits	144	Target Neighborhood Hits	291	Shared Neighborhood Hits	49
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.079022 (rank : 355)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	51
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.071862 (rank : 410)
Query Neighborhood Hits	144	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.075539 (rank : 383)
Query Neighborhood Hits	144	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 453)	NC score	0.080088 (rank : 349)
Query Neighborhood Hits	144	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.102152 (rank : 172)
Query Neighborhood Hits	144	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.099530 (rank : 190)
Query Neighborhood Hits	144	Target Neighborhood Hits	332	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 456)	NC score	0.053295 (rank : 489)
Query Neighborhood Hits	144	Target Neighborhood Hits	446	Shared Neighborhood Hits	42
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SLAP1_HUMAN
θ value	θ > 10 (rank : 457)	NC score	0.282201 (rank : 64)
Query Neighborhood Hits	144	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 458)	NC score	0.281436 (rank : 65)
Query Neighborhood Hits	144	Target Neighborhood Hits	117	Shared Neighborhood Hits	97
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.304164 (rank : 58)
Query Neighborhood Hits	144	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS1_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.099628 (rank : 189)
Query Neighborhood Hits	144	Target Neighborhood Hits	79	Shared Neighborhood Hits	50
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.100267 (rank : 181)
Query Neighborhood Hits	144	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS3_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.113936 (rank : 139)
Query Neighborhood Hits	144	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.112812 (rank : 142)
Query Neighborhood Hits	144	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS5_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.098426 (rank : 200)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	62
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.097909 (rank : 209)
Query Neighborhood Hits	144	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SPN90_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.088220 (rank : 312)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.080102 (rank : 348)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA2_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.050187 (rank : 521)
Query Neighborhood Hits	144	Target Neighborhood Hits	888	Shared Neighborhood Hits	53
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 469)	NC score	0.110537 (rank : 148)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 470)	NC score	0.111704 (rank : 144)
Query Neighborhood Hits	144	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 471)	NC score	0.092867 (rank : 263)
Query Neighborhood Hits	144	Target Neighborhood Hits	269	Shared Neighborhood Hits	52
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.089863 (rank : 291)
Query Neighborhood Hits	144	Target Neighborhood Hits	292	Shared Neighborhood Hits	52
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.069994 (rank : 417)
Query Neighborhood Hits	144	Target Neighborhood Hits	390	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 474)	NC score	0.075296 (rank : 384)
Query Neighborhood Hits	144	Target Neighborhood Hits	331	Shared Neighborhood Hits	54
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 475)	NC score	0.073994 (rank : 397)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	53
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 476)	NC score	0.162370 (rank : 128)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 477)	NC score	0.166889 (rank : 123)
Query Neighborhood Hits	144	Target Neighborhood Hits	964	Shared Neighborhood Hits	113
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STAC3_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.113514 (rank : 141)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 479)	NC score	0.113557 (rank : 140)
Query Neighborhood Hits	144	Target Neighborhood Hits	232	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 480)	NC score	0.108576 (rank : 150)
Query Neighborhood Hits	144	Target Neighborhood Hits	276	Shared Neighborhood Hits	58
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 481)	NC score	0.114376 (rank : 138)
Query Neighborhood Hits	144	Target Neighborhood Hits	268	Shared Neighborhood Hits	56
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.106934 (rank : 156)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.106445 (rank : 160)
Query Neighborhood Hits	144	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 484)	NC score	0.105329 (rank : 168)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 485)	NC score	0.106783 (rank : 157)
Query Neighborhood Hits	144	Target Neighborhood Hits	285	Shared Neighborhood Hits	50
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STK16_HUMAN
θ value	θ > 10 (rank : 486)	NC score	0.052393 (rank : 496)
Query Neighborhood Hits	144	Target Neighborhood Hits	824	Shared Neighborhood Hits	43
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
θ value	θ > 10 (rank : 487)	NC score	0.053461 (rank : 486)
Query Neighborhood Hits	144	Target Neighborhood Hits	824	Shared Neighborhood Hits	43
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

STK24_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.053496 (rank : 484)
Query Neighborhood Hits	144	Target Neighborhood Hits	853	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.053937 (rank : 478)
Query Neighborhood Hits	144	Target Neighborhood Hits	856	Shared Neighborhood Hits	43
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.052030 (rank : 499)
Query Neighborhood Hits	144	Target Neighborhood Hits	853	Shared Neighborhood Hits	43
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.052296 (rank : 497)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK39_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.056584 (rank : 469)
Query Neighborhood Hits	144	Target Neighborhood Hits	882	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.056626 (rank : 468)
Query Neighborhood Hits	144	Target Neighborhood Hits	915	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STYK1_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.107500 (rank : 152)
Query Neighborhood Hits	144	Target Neighborhood Hits	786	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.106502 (rank : 159)
Query Neighborhood Hits	144	Target Neighborhood Hits	779	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TAOK2_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.050212 (rank : 520)
Query Neighborhood Hits	144	Target Neighborhood Hits	1172	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TENS1_HUMAN
θ value	θ > 10 (rank : 497)	NC score	0.067282 (rank : 434)
Query Neighborhood Hits	144	Target Neighborhood Hits	400	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TENS4_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.081547 (rank : 341)
Query Neighborhood Hits	144	Target Neighborhood Hits	214	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.088086 (rank : 315)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TESK1_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.068296 (rank : 423)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK1_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.067708 (rank : 431)
Query Neighborhood Hits	144	Target Neighborhood Hits	862	Shared Neighborhood Hits	43
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.070660 (rank : 414)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	45
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.069673 (rank : 418)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TEX14_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.090937 (rank : 280)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.089565 (rank : 296)
Query Neighborhood Hits	144	Target Neighborhood Hits	1333	Shared Neighborhood Hits	45
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGFR1_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.067843 (rank : 429)
Query Neighborhood Hits	144	Target Neighborhood Hits	755	Shared Neighborhood Hits	43
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.067757 (rank : 430)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TIE1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.090683 (rank : 283)
Query Neighborhood Hits	144	Target Neighborhood Hits	1241	Shared Neighborhood Hits	43
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.090435 (rank : 287)
Query Neighborhood Hits	144	Target Neighborhood Hits	1266	Shared Neighborhood Hits	43
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.089605 (rank : 295)
Query Neighborhood Hits	144	Target Neighborhood Hits	1192	Shared Neighborhood Hits	43
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.089552 (rank : 297)
Query Neighborhood Hits	144	Target Neighborhood Hits	1204	Shared Neighborhood Hits	43
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TNI3K_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.071645 (rank : 411)
Query Neighborhood Hits	144	Target Neighborhood Hits	1084	Shared Neighborhood Hits	45
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.072076 (rank : 408)
Query Neighborhood Hits	144	Target Neighborhood Hits	1079	Shared Neighborhood Hits	45
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNK1_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.100041 (rank : 183)
Query Neighborhood Hits	144	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.099937 (rank : 185)
Query Neighborhood Hits	144	Target Neighborhood Hits	806	Shared Neighborhood Hits	50
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TOPK_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.068588 (rank : 420)
Query Neighborhood Hits	144	Target Neighborhood Hits	605	Shared Neighborhood Hits	43
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TOPK_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.068602 (rank : 419)
Query Neighborhood Hits	144	Target Neighborhood Hits	618	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TSSK4_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.050078 (rank : 523)
Query Neighborhood Hits	144	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TYK2_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.084030 (rank : 334)
Query Neighborhood Hits	144	Target Neighborhood Hits	841	Shared Neighborhood Hits	43
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.085764 (rank : 323)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 521)	NC score	0.094335 (rank : 251)
Query Neighborhood Hits	144	Target Neighborhood Hits	995	Shared Neighborhood Hits	43
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 522)	NC score	0.094626 (rank : 249)
Query Neighborhood Hits	144	Target Neighborhood Hits	1007	Shared Neighborhood Hits	43
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 523)	NC score	0.097679 (rank : 211)
Query Neighborhood Hits	144	Target Neighborhood Hits	981	Shared Neighborhood Hits	43
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 524)	NC score	0.096681 (rank : 220)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VGFR1_HUMAN
θ value	θ > 10 (rank : 525)	NC score	0.084484 (rank : 330)
Query Neighborhood Hits	144	Target Neighborhood Hits	1109	Shared Neighborhood Hits	43
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 526)	NC score	0.084087 (rank : 332)
Query Neighborhood Hits	144	Target Neighborhood Hits	1118	Shared Neighborhood Hits	43
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 527)	NC score	0.086764 (rank : 321)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	45
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 528)	NC score	0.086669 (rank : 322)
Query Neighborhood Hits	144	Target Neighborhood Hits	1089	Shared Neighborhood Hits	43
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.089238 (rank : 300)
Query Neighborhood Hits	144	Target Neighborhood Hits	1037	Shared Neighborhood Hits	43
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.088708 (rank : 308)
Query Neighborhood Hits	144	Target Neighborhood Hits	1056	Shared Neighborhood Hits	43
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VINEX_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.110191 (rank : 149)
Query Neighborhood Hits	144	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.112432 (rank : 143)
Query Neighborhood Hits	144	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YSK4_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.053652 (rank : 482)
Query Neighborhood Hits	144	Target Neighborhood Hits	921	Shared Neighborhood Hits	44
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

Hits sorted by NC score

SHC2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC2_HUMAN
NC score	0.992630 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	136
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC1_MOUSE
NC score	0.967326 (rank : 3)	θ value	5.07123e-136 (rank : 3)
Query Neighborhood Hits	144	Target Neighborhood Hits	180	Shared Neighborhood Hits	126
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_HUMAN
NC score	0.966790 (rank : 4)	θ value	4.29305e-135 (rank : 4)
Query Neighborhood Hits	144	Target Neighborhood Hits	170	Shared Neighborhood Hits	124
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC3_MOUSE
NC score	0.962372 (rank : 5)	θ value	3.5201e-129 (rank : 5)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	122
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHC3_HUMAN
NC score	0.955443 (rank : 6)	θ value	3.89193e-128 (rank : 6)
Query Neighborhood Hits	144	Target Neighborhood Hits	155	Shared Neighborhood Hits	118
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

APS_HUMAN
NC score	0.561739 (rank : 7)	θ value	1.80886e-08 (rank : 10)
Query Neighborhood Hits	144	Target Neighborhood Hits	162	Shared Neighborhood Hits	106
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

LNK_MOUSE
NC score	0.544581 (rank : 8)	θ value	1.17247e-07 (rank : 13)
Query Neighborhood Hits	144	Target Neighborhood Hits	132	Shared Neighborhood Hits	103
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

SH23A_HUMAN
NC score	0.535343 (rank : 9)	θ value	5.81887e-07 (rank : 16)
Query Neighborhood Hits	144	Target Neighborhood Hits	149	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

LNK_HUMAN
NC score	0.535066 (rank : 10)	θ value	1.69304e-06 (rank : 21)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

BCAR3_HUMAN
NC score	0.529263 (rank : 11)	θ value	2.13673e-09 (rank : 8)
Query Neighborhood Hits	144	Target Neighborhood Hits	129	Shared Neighborhood Hits	91
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
NC score	0.528000 (rank : 12)	θ value	2.13673e-09 (rank : 9)
Query Neighborhood Hits	144	Target Neighborhood Hits	127	Shared Neighborhood Hits	90
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

APS_MOUSE
NC score	0.511620 (rank : 13)	θ value	3.41135e-07 (rank : 15)
Query Neighborhood Hits	144	Target Neighborhood Hits	134	Shared Neighborhood Hits	90
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SHD_MOUSE
NC score	0.504575 (rank : 14)	θ value	0.000121331 (rank : 50)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	115
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SH2D3_MOUSE
NC score	0.502754 (rank : 15)	θ value	1.17247e-07 (rank : 14)
Query Neighborhood Hits	144	Target Neighborhood Hits	174	Shared Neighborhood Hits	96
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH2D3_HUMAN
NC score	0.500796 (rank : 16)	θ value	8.97725e-08 (rank : 12)
Query Neighborhood Hits	144	Target Neighborhood Hits	188	Shared Neighborhood Hits	94
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SHD_HUMAN
NC score	0.492459 (rank : 17)	θ value	1.69304e-06 (rank : 22)
Query Neighborhood Hits	144	Target Neighborhood Hits	204	Shared Neighborhood Hits	111
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
NC score	0.475914 (rank : 18)	θ value	7.1131e-05 (rank : 45)
Query Neighborhood Hits	144	Target Neighborhood Hits	164	Shared Neighborhood Hits	113
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_MOUSE
NC score	0.470373 (rank : 19)	θ value	0.000121331 (rank : 49)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	113
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHE_MOUSE
NC score	0.468160 (rank : 20)	θ value	0.000461057 (rank : 62)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHB_HUMAN
NC score	0.464300 (rank : 21)	θ value	0.000121331 (rank : 48)
Query Neighborhood Hits	144	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRAP_HUMAN
NC score	0.463441 (rank : 22)	θ value	1.09739e-05 (rank : 26)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	116
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.462525 (rank : 23)	θ value	1.43324e-05 (rank : 28)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	124
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP_MOUSE
NC score	0.458547 (rank : 24)	θ value	2.44474e-05 (rank : 35)
Query Neighborhood Hits	144	Target Neighborhood Hits	309	Shared Neighborhood Hits	116
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_MOUSE
NC score	0.454242 (rank : 25)	θ value	1.29631e-06 (rank : 19)
Query Neighborhood Hits	144	Target Neighborhood Hits	312	Shared Neighborhood Hits	124
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.453917 (rank : 26)	θ value	1.29631e-06 (rank : 18)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	122
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

CRK_HUMAN
NC score	0.448790 (rank : 27)	θ value	0.00020696 (rank : 53)
Query Neighborhood Hits	144	Target Neighborhood Hits	308	Shared Neighborhood Hits	122
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NCK2_HUMAN
NC score	0.447904 (rank : 28)	θ value	0.000461057 (rank : 61)
Query Neighborhood Hits	144	Target Neighborhood Hits	310	Shared Neighborhood Hits	128
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

GRB14_MOUSE
NC score	0.446570 (rank : 29)	θ value	2.88788e-06 (rank : 23)
Query Neighborhood Hits	144	Target Neighborhood Hits	149	Shared Neighborhood Hits	110
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_MOUSE
NC score	0.446055 (rank : 30)	θ value	1.29631e-06 (rank : 20)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	110
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

DAPP1_HUMAN
NC score	0.445949 (rank : 31)	θ value	0.00298849 (rank : 78)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CRK_MOUSE
NC score	0.444148 (rank : 32)	θ value	0.00020696 (rank : 54)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	122
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GRB14_HUMAN
NC score	0.442740 (rank : 33)	θ value	8.40245e-06 (rank : 25)
Query Neighborhood Hits	144	Target Neighborhood Hits	137	Shared Neighborhood Hits	110
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

CRKL_HUMAN
NC score	0.436656 (rank : 34)	θ value	0.00298849 (rank : 77)
Query Neighborhood Hits	144	Target Neighborhood Hits	313	Shared Neighborhood Hits	118
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.433610 (rank : 35)	θ value	0.00665767 (rank : 84)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	118
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRB7_HUMAN
NC score	0.425659 (rank : 36)	θ value	1.87187e-05 (rank : 29)
Query Neighborhood Hits	144	Target Neighborhood Hits	156	Shared Neighborhood Hits	109
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

DAPP1_MOUSE
NC score	0.417929 (rank : 37)	θ value	0.00665767 (rank : 85)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	126
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

SH21B_MOUSE
NC score	0.408204 (rank : 38)	θ value	0.0736092 (rank : 102)
Query Neighborhood Hits	144	Target Neighborhood Hits	101	Shared Neighborhood Hits	91
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21A_MOUSE
NC score	0.405820 (rank : 39)	θ value	0.00228821 (rank : 76)
Query Neighborhood Hits	144	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

GRAP2_HUMAN
NC score	0.405608 (rank : 40)	θ value	0.00102713 (rank : 66)
Query Neighborhood Hits	144	Target Neighborhood Hits	304	Shared Neighborhood Hits	111
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH21B_HUMAN
NC score	0.404206 (rank : 41)	θ value	0.0736092 (rank : 101)
Query Neighborhood Hits	144	Target Neighborhood Hits	101	Shared Neighborhood Hits	94
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21A_HUMAN
NC score	0.402285 (rank : 42)	θ value	0.00298849 (rank : 80)
Query Neighborhood Hits	144	Target Neighborhood Hits	89	Shared Neighborhood Hits	82
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

RASA1_HUMAN
NC score	0.396234 (rank : 43)	θ value	0.00228821 (rank : 75)
Query Neighborhood Hits	144	Target Neighborhood Hits	258	Shared Neighborhood Hits	117
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

GRAP2_MOUSE
NC score	0.395526 (rank : 44)	θ value	0.00390308 (rank : 82)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	111
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB10_MOUSE
NC score	0.390321 (rank : 45)	θ value	5.44631e-05 (rank : 40)
Query Neighborhood Hits	144	Target Neighborhood Hits	156	Shared Neighborhood Hits	105
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.385230 (rank : 46)	θ value	7.1131e-05 (rank : 43)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	105
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

PLCG2_HUMAN
NC score	0.384210 (rank : 47)	θ value	1.87187e-05 (rank : 30)
Query Neighborhood Hits	144	Target Neighborhood Hits	280	Shared Neighborhood Hits	120
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLCG1_HUMAN
NC score	0.370615 (rank : 48)	θ value	0.00298849 (rank : 79)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	123
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.367488 (rank : 49)	θ value	0.00509761 (rank : 83)
Query Neighborhood Hits	144	Target Neighborhood Hits	314	Shared Neighborhood Hits	123
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

VAV3_HUMAN
NC score	0.353023 (rank : 50)	θ value	1.87187e-05 (rank : 31)
Query Neighborhood Hits	144	Target Neighborhood Hits	398	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.352860 (rank : 51)	θ value	1.87187e-05 (rank : 32)
Query Neighborhood Hits	144	Target Neighborhood Hits	404	Shared Neighborhood Hits	113
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
NC score	0.345220 (rank : 52)	θ value	2.88788e-06 (rank : 24)
Query Neighborhood Hits	144	Target Neighborhood Hits	452	Shared Neighborhood Hits	109
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

HSH2D_HUMAN
NC score	0.332524 (rank : 53)	θ value	0.279714 (rank : 112)
Query Neighborhood Hits	144	Target Neighborhood Hits	159	Shared Neighborhood Hits	108
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

VAV2_MOUSE
NC score	0.326894 (rank : 54)	θ value	0.000270298 (rank : 60)
Query Neighborhood Hits	144	Target Neighborhood Hits	456	Shared Neighborhood Hits	112
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.326185 (rank : 55)	θ value	0.00134147 (rank : 70)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	113
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.324010 (rank : 56)	θ value	2.44474e-05 (rank : 37)
Query Neighborhood Hits	144	Target Neighborhood Hits	430	Shared Neighborhood Hits	104
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

SLAP2_HUMAN
NC score	0.311664 (rank : 57)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	144	Target Neighborhood Hits	139	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
NC score	0.304164 (rank : 58)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	144	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SOCS2_HUMAN
NC score	0.299235 (rank : 59)	θ value	0.000270298 (rank : 59)
Query Neighborhood Hits	144	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

P85A_MOUSE
NC score	0.294813 (rank : 60)	θ value	7.1131e-05 (rank : 44)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	112
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SOCS2_MOUSE
NC score	0.293917 (rank : 61)	θ value	0.000786445 (rank : 65)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	74
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SH22A_MOUSE
NC score	0.289668 (rank : 62)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	144	Target Neighborhood Hits	179	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

P85A_HUMAN
NC score	0.289027 (rank : 63)	θ value	0.000121331 (rank : 47)
Query Neighborhood Hits	144	Target Neighborhood Hits	479	Shared Neighborhood Hits	111
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SLAP1_HUMAN
NC score	0.282201 (rank : 64)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	144	Target Neighborhood Hits	113	Shared Neighborhood Hits	96
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.281436 (rank : 65)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	144	Target Neighborhood Hits	117	Shared Neighborhood Hits	97
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

HSH2D_MOUSE
NC score	0.280368 (rank : 66)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	144	Target Neighborhood Hits	124	Shared Neighborhood Hits	91
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

PTN11_MOUSE
NC score	0.279688 (rank : 67)	θ value	0.000270298 (rank : 58)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.279656 (rank : 68)	θ value	0.000270298 (rank : 57)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	122
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SH24A_HUMAN
NC score	0.269270 (rank : 69)	θ value	0.163984 (rank : 109)
Query Neighborhood Hits	144	Target Neighborhood Hits	455	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH22A_HUMAN
NC score	0.268213 (rank : 70)	θ value	5.27518 (rank : 140)
Query Neighborhood Hits	144	Target Neighborhood Hits	144	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

P85B_HUMAN
NC score	0.268006 (rank : 71)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	144	Target Neighborhood Hits	543	Shared Neighborhood Hits	114
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

LCP2_MOUSE
NC score	0.264891 (rank : 72)	θ value	0.0148317 (rank : 95)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

P85B_MOUSE
NC score	0.264435 (rank : 73)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	144	Target Neighborhood Hits	519	Shared Neighborhood Hits	113
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_HUMAN
NC score	0.264231 (rank : 74)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	144	Target Neighborhood Hits	451	Shared Neighborhood Hits	105
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
NC score	0.255912 (rank : 75)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	144	Target Neighborhood Hits	401	Shared Neighborhood Hits	102
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH24A_MOUSE
NC score	0.252206 (rank : 76)	θ value	0.62314 (rank : 120)
Query Neighborhood Hits	144	Target Neighborhood Hits	326	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

PTN6_MOUSE
NC score	0.248377 (rank : 77)	θ value	9.29e-05 (rank : 46)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	118
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

LCP2_HUMAN
NC score	0.246416 (rank : 78)	θ value	0.00665767 (rank : 86)
Query Neighborhood Hits	144	Target Neighborhood Hits	531	Shared Neighborhood Hits	76
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PTN6_HUMAN
NC score	0.244718 (rank : 79)	θ value	2.44474e-05 (rank : 36)
Query Neighborhood Hits	144	Target Neighborhood Hits	234	Shared Neighborhood Hits	112
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

SOCS6_MOUSE
NC score	0.224076 (rank : 80)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	144	Target Neighborhood Hits	146	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FGR_MOUSE
NC score	0.218513 (rank : 81)	θ value	0.000602161 (rank : 63)
Query Neighborhood Hits	144	Target Neighborhood Hits	1069	Shared Neighborhood Hits	127
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ABL2_HUMAN
NC score	0.218071 (rank : 82)	θ value	1.43324e-05 (rank : 27)
Query Neighborhood Hits	144	Target Neighborhood Hits	1045	Shared Neighborhood Hits	126
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FER_HUMAN
NC score	0.214536 (rank : 83)	θ value	7.84624e-12 (rank : 7)
Query Neighborhood Hits	144	Target Neighborhood Hits	1278	Shared Neighborhood Hits	123
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ABL1_HUMAN
NC score	0.212479 (rank : 84)	θ value	7.1131e-05 (rank : 41)
Query Neighborhood Hits	144	Target Neighborhood Hits	1220	Shared Neighborhood Hits	124
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
NC score	0.212104 (rank : 85)	θ value	7.1131e-05 (rank : 42)
Query Neighborhood Hits	144	Target Neighborhood Hits	1178	Shared Neighborhood Hits	124
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK_MOUSE
NC score	0.210594 (rank : 86)	θ value	3.19293e-05 (rank : 38)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	121
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.209935 (rank : 87)	θ value	4.1701e-05 (rank : 39)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	121
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

FGR_HUMAN
NC score	0.208384 (rank : 88)	θ value	0.00134147 (rank : 69)
Query Neighborhood Hits	144	Target Neighborhood Hits	1067	Shared Neighborhood Hits	125
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_MOUSE
NC score	0.205988 (rank : 89)	θ value	0.000121331 (rank : 52)
Query Neighborhood Hits	144	Target Neighborhood Hits	1033	Shared Neighborhood Hits	120
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_HUMAN
NC score	0.205658 (rank : 90)	θ value	0.00175202 (rank : 72)
Query Neighborhood Hits	144	Target Neighborhood Hits	1059	Shared Neighborhood Hits	114
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SRC_HUMAN
NC score	0.205102 (rank : 91)	θ value	0.000121331 (rank : 51)
Query Neighborhood Hits	144	Target Neighborhood Hits	1058	Shared Neighborhood Hits	120
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SOCS6_HUMAN
NC score	0.204690 (rank : 92)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	82
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

YES_MOUSE
NC score	0.204528 (rank : 93)	θ value	0.00298849 (rank : 81)
Query Neighborhood Hits	144	Target Neighborhood Hits	1052	Shared Neighborhood Hits	114
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BLNK_MOUSE
NC score	0.203313 (rank : 94)	θ value	0.163984 (rank : 107)
Query Neighborhood Hits	144	Target Neighborhood Hits	296	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

FYN_MOUSE
NC score	0.200463 (rank : 95)	θ value	0.00228821 (rank : 74)
Query Neighborhood Hits	144	Target Neighborhood Hits	1073	Shared Neighborhood Hits	118
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

FYN_HUMAN
NC score	0.199181 (rank : 96)	θ value	0.00228821 (rank : 73)
Query Neighborhood Hits	144	Target Neighborhood Hits	1078	Shared Neighborhood Hits	121
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FRK_HUMAN
NC score	0.198421 (rank : 97)	θ value	0.000270298 (rank : 56)
Query Neighborhood Hits	144	Target Neighborhood Hits	1058	Shared Neighborhood Hits	121
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MATK_HUMAN
NC score	0.196741 (rank : 98)	θ value	0.000786445 (rank : 64)
Query Neighborhood Hits	144	Target Neighborhood Hits	954	Shared Neighborhood Hits	122
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
NC score	0.195642 (rank : 99)	θ value	0.00020696 (rank : 55)
Query Neighborhood Hits	144	Target Neighborhood Hits	952	Shared Neighborhood Hits	119
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

CHIN_MOUSE
NC score	0.194852 (rank : 100)	θ value	0.0193708 (rank : 96)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	95
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SOCS7_MOUSE
NC score	0.190424 (rank : 101)	θ value	1.38821 (rank : 126)
Query Neighborhood Hits	144	Target Neighborhood Hits	154	Shared Neighborhood Hits	79
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

CHIN_HUMAN
NC score	0.186910 (rank : 102)	θ value	0.00869519 (rank : 87)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	88
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LCK_HUMAN
NC score	0.182982 (rank : 103)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	144	Target Neighborhood Hits	987	Shared Neighborhood Hits	109
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

PTK6_MOUSE
NC score	0.182972 (rank : 104)	θ value	0.00102713 (rank : 67)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	113
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

HCK_MOUSE
NC score	0.182711 (rank : 105)	θ value	0.0563607 (rank : 98)
Query Neighborhood Hits	144	Target Neighborhood Hits	1029	Shared Neighborhood Hits	105
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.182151 (rank : 106)	θ value	0.0961366 (rank : 103)
Query Neighborhood Hits	144	Target Neighborhood Hits	1035	Shared Neighborhood Hits	109
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

LCK_MOUSE
NC score	0.181436 (rank : 107)	θ value	0.365318 (rank : 116)
Query Neighborhood Hits	144	Target Neighborhood Hits	981	Shared Neighborhood Hits	111
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BLK_MOUSE
NC score	0.180665 (rank : 108)	θ value	0.125558 (rank : 104)
Query Neighborhood Hits	144	Target Neighborhood Hits	992	Shared Neighborhood Hits	109
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PTK6_HUMAN
NC score	0.179102 (rank : 109)	θ value	0.00869519 (rank : 90)
Query Neighborhood Hits	144	Target Neighborhood Hits	1020	Shared Neighborhood Hits	112
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

BTK_HUMAN
NC score	0.178962 (rank : 110)	θ value	0.00134147 (rank : 68)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	100
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.178850 (rank : 111)	θ value	0.00175202 (rank : 71)
Query Neighborhood Hits	144	Target Neighborhood Hits	1017	Shared Neighborhood Hits	100
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

KSYK_HUMAN
NC score	0.177580 (rank : 112)	θ value	0.0113563 (rank : 92)
Query Neighborhood Hits	144	Target Neighborhood Hits	901	Shared Neighborhood Hits	114
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

FES_HUMAN
NC score	0.176380 (rank : 113)	θ value	8.97725e-08 (rank : 11)
Query Neighborhood Hits	144	Target Neighborhood Hits	978	Shared Neighborhood Hits	92
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

BLK_HUMAN
NC score	0.176148 (rank : 114)	θ value	0.0252991 (rank : 97)
Query Neighborhood Hits	144	Target Neighborhood Hits	994	Shared Neighborhood Hits	99
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LYN_MOUSE
NC score	0.175770 (rank : 115)	θ value	0.21417 (rank : 111)
Query Neighborhood Hits	144	Target Neighborhood Hits	1023	Shared Neighborhood Hits	108
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CISH_HUMAN
NC score	0.173487 (rank : 116)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

BLNK_HUMAN
NC score	0.173323 (rank : 117)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

KSYK_MOUSE
NC score	0.173266 (rank : 118)	θ value	0.0563607 (rank : 99)
Query Neighborhood Hits	144	Target Neighborhood Hits	944	Shared Neighborhood Hits	116
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LYN_HUMAN
NC score	0.173248 (rank : 119)	θ value	0.62314 (rank : 119)
Query Neighborhood Hits	144	Target Neighborhood Hits	1022	Shared Neighborhood Hits	108
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CISH_MOUSE
NC score	0.169560 (rank : 120)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	144	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

TXK_MOUSE
NC score	0.169132 (rank : 121)	θ value	0.163984 (rank : 110)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	113
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FES_MOUSE
NC score	0.167254 (rank : 122)	θ value	7.59969e-07 (rank : 17)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	81
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SRMS_MOUSE
NC score	0.166889 (rank : 123)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	144	Target Neighborhood Hits	964	Shared Neighborhood Hits	113
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BMX_MOUSE
NC score	0.165802 (rank : 124)	θ value	0.125558 (rank : 105)
Query Neighborhood Hits	144	Target Neighborhood Hits	912	Shared Neighborhood Hits	101
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TEC_HUMAN
NC score	0.165797 (rank : 125)	θ value	0.00869519 (rank : 91)
Query Neighborhood Hits	144	Target Neighborhood Hits	1006	Shared Neighborhood Hits	98
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BMX_HUMAN
NC score	0.164857 (rank : 126)	θ value	0.163984 (rank : 108)
Query Neighborhood Hits	144	Target Neighborhood Hits	942	Shared Neighborhood Hits	102
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ITK_HUMAN
NC score	0.162453 (rank : 127)	θ value	0.125558 (rank : 106)
Query Neighborhood Hits	144	Target Neighborhood Hits	1016	Shared Neighborhood Hits	106
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SRMS_HUMAN
NC score	0.162370 (rank : 128)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

ITK_MOUSE
NC score	0.161938 (rank : 129)	θ value	0.0148317 (rank : 94)
Query Neighborhood Hits	144	Target Neighborhood Hits	985	Shared Neighborhood Hits	104
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TXK_HUMAN
NC score	0.160793 (rank : 130)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	144	Target Neighborhood Hits	971	Shared Neighborhood Hits	106
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TEC_MOUSE
NC score	0.158863 (rank : 131)	θ value	0.0563607 (rank : 100)
Query Neighborhood Hits	144	Target Neighborhood Hits	1006	Shared Neighborhood Hits	94
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZAP70_MOUSE
NC score	0.153841 (rank : 132)	θ value	0.813845 (rank : 122)
Query Neighborhood Hits	144	Target Neighborhood Hits	905	Shared Neighborhood Hits	112
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZAP70_HUMAN
NC score	0.152472 (rank : 133)	θ value	0.813845 (rank : 121)
Query Neighborhood Hits	144	Target Neighborhood Hits	893	Shared Neighborhood Hits	111
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CHIO_HUMAN
NC score	0.148961 (rank : 134)	θ value	0.365318 (rank : 113)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	83
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

NPHP1_MOUSE
NC score	0.137410 (rank : 135)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	144	Target Neighborhood Hits	267	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ARH_HUMAN
NC score	0.130571 (rank : 136)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	144	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

NPHP1_HUMAN
NC score	0.124409 (rank : 137)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	55
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

STAC_MOUSE
NC score	0.114376 (rank : 138)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	144	Target Neighborhood Hits	268	Shared Neighborhood Hits	56
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SOCS3_HUMAN
NC score	0.113936 (rank : 139)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	144	Target Neighborhood Hits	77	Shared Neighborhood Hits	50
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

STAC3_MOUSE
NC score	0.113557 (rank : 140)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	144	Target Neighborhood Hits	232	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.113514 (rank : 141)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	144	Target Neighborhood Hits	228	Shared Neighborhood Hits	52
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SOCS3_MOUSE
NC score	0.112812 (rank : 142)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	144	Target Neighborhood Hits	72	Shared Neighborhood Hits	50
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

VINEX_MOUSE
NC score	0.112432 (rank : 143)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	144	Target Neighborhood Hits	286	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_MOUSE
NC score	0.111704 (rank : 144)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	144	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NUMB_MOUSE
NC score	0.111218 (rank : 145)	θ value	0.00869519 (rank : 89)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

CD2AP_HUMAN
NC score	0.110961 (rank : 146)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	144	Target Neighborhood Hits	315	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

NUMB_HUMAN
NC score	0.110911 (rank : 147)	θ value	0.00869519 (rank : 88)
Query Neighborhood Hits	144	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

SRBS1_HUMAN
NC score	0.110537 (rank : 148)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_HUMAN
NC score	0.110191 (rank : 149)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	144	Target Neighborhood Hits	270	Shared Neighborhood Hits	53
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

STAC_HUMAN
NC score	0.108576 (rank : 150)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	144	Target Neighborhood Hits	276	Shared Neighborhood Hits	58
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

OSTF1_HUMAN
NC score	0.107761 (rank : 151)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	144	Target Neighborhood Hits	466	Shared Neighborhood Hits	54
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

STYK1_HUMAN
NC score	0.107500 (rank : 152)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	144	Target Neighborhood Hits	786	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

RYK_HUMAN
NC score	0.107480 (rank : 153)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	144	Target Neighborhood Hits	701	Shared Neighborhood Hits	43
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ANKS1_MOUSE
NC score	0.107106 (rank : 154)	θ value	2.44474e-05 (rank : 34)
Query Neighborhood Hits	144	Target Neighborhood Hits	453	Shared Neighborhood Hits	17
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

LTK_HUMAN
NC score	0.107097 (rank : 155)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	144	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

STAM1_HUMAN
NC score	0.106934 (rank : 156)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	51
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.106783 (rank : 157)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	144	Target Neighborhood Hits	285	Shared Neighborhood Hits	50
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

RYK_MOUSE
NC score	0.106620 (rank : 158)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

STYK1_MOUSE
NC score	0.106502 (rank : 159)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	144	Target Neighborhood Hits	779	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

STAM1_MOUSE
NC score	0.106445 (rank : 160)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	144	Target Neighborhood Hits	273	Shared Neighborhood Hits	49
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ACK1_MOUSE
NC score	0.106331 (rank : 161)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	144	Target Neighborhood Hits	1080	Shared Neighborhood Hits	55
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

DNMBP_HUMAN
NC score	0.106103 (rank : 162)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	144	Target Neighborhood Hits	413	Shared Neighborhood Hits	59
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

LTK_MOUSE
NC score	0.105981 (rank : 163)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	144	Target Neighborhood Hits	770	Shared Neighborhood Hits	43
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ACK1_HUMAN
NC score	0.105894 (rank : 164)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	144	Target Neighborhood Hits	1140	Shared Neighborhood Hits	55
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ALK_MOUSE
NC score	0.105710 (rank : 165)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	144	Target Neighborhood Hits	811	Shared Neighborhood Hits	43
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

CD2AP_MOUSE
NC score	0.105426 (rank : 166)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	144	Target Neighborhood Hits	336	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ALK_HUMAN
NC score	0.105362 (rank : 167)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	144	Target Neighborhood Hits	795	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

STAM2_HUMAN
NC score	0.105329 (rank : 168)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ROS_HUMAN
NC score	0.103595 (rank : 169)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	144	Target Neighborhood Hits	907	Shared Neighborhood Hits	43
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

OSTF1_MOUSE
NC score	0.102759 (rank : 170)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	144	Target Neighborhood Hits	467	Shared Neighborhood Hits	54
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PPIP1_HUMAN
NC score	0.102510 (rank : 171)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	58
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SH3K1_HUMAN
NC score	0.102152 (rank : 172)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	144	Target Neighborhood Hits	341	Shared Neighborhood Hits	51
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

FAK2_HUMAN
NC score	0.101587 (rank : 173)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

AATK_MOUSE
NC score	0.101300 (rank : 174)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	144	Target Neighborhood Hits	942	Shared Neighborhood Hits	44
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

EPHAA_HUMAN
NC score	0.101173 (rank : 175)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	144	Target Neighborhood Hits	960	Shared Neighborhood Hits	46
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ANKS1_HUMAN
NC score	0.101069 (rank : 176)	θ value	2.44474e-05 (rank : 33)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	18
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

FAK2_MOUSE
NC score	0.100889 (rank : 177)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

DDR1_MOUSE
NC score	0.100450 (rank : 178)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	144	Target Neighborhood Hits	818	Shared Neighborhood Hits	43
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

PPIP1_MOUSE
NC score	0.100413 (rank : 179)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	144	Target Neighborhood Hits	377	Shared Neighborhood Hits	56
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

DNMBP_MOUSE
NC score	0.100409 (rank : 180)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	144	Target Neighborhood Hits	435	Shared Neighborhood Hits	59
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SOCS1_MOUSE
NC score	0.100267 (rank : 181)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	144	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

DDR1_HUMAN
NC score	0.100211 (rank : 182)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	144	Target Neighborhood Hits	819	Shared Neighborhood Hits	43
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

TNK1_HUMAN
NC score	0.100041 (rank : 183)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	144	Target Neighborhood Hits	815	Shared Neighborhood Hits	47
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

FLT3_MOUSE
NC score	0.099959 (rank : 184)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

TNK1_MOUSE
NC score	0.099937 (rank : 185)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	144	Target Neighborhood Hits	806	Shared Neighborhood Hits	50
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

MERTK_HUMAN
NC score	0.099899 (rank : 186)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ARHG7_MOUSE
NC score	0.099858 (rank : 187)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	144	Target Neighborhood Hits	396	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

EPHB6_HUMAN
NC score	0.099664 (rank : 188)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	144	Target Neighborhood Hits	912	Shared Neighborhood Hits	46
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

SOCS1_HUMAN
NC score	0.099628 (rank : 189)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	144	Target Neighborhood Hits	79	Shared Neighborhood Hits	50
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SH3K1_MOUSE
NC score	0.099530 (rank : 190)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	144	Target Neighborhood Hits	332	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

MERTK_MOUSE
NC score	0.099471 (rank : 191)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	144	Target Neighborhood Hits	974	Shared Neighborhood Hits	43
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

IGF1R_MOUSE
NC score	0.099435 (rank : 192)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	144	Target Neighborhood Hits	973	Shared Neighborhood Hits	43
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_HUMAN
NC score	0.099404 (rank : 193)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	144	Target Neighborhood Hits	977	Shared Neighborhood Hits	43
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

FLT3_HUMAN
NC score	0.099261 (rank : 194)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	144	Target Neighborhood Hits	843	Shared Neighborhood Hits	43
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

ARHG7_HUMAN
NC score	0.099216 (rank : 195)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	144	Target Neighborhood Hits	347	Shared Neighborhood Hits	51
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

EPHB6_MOUSE
NC score	0.098952 (rank : 196)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	144	Target Neighborhood Hits	906	Shared Neighborhood Hits	45
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ARHG6_HUMAN
NC score	0.098576 (rank : 197)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	144	Target Neighborhood Hits	376	Shared Neighborhood Hits	49
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CSF1R_HUMAN
NC score	0.098447 (rank : 198)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	144	Target Neighborhood Hits	943	Shared Neighborhood Hits	43
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

NTRK1_HUMAN
NC score	0.098435 (rank : 199)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	144	Target Neighborhood Hits	1023	Shared Neighborhood Hits	44
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SOCS5_HUMAN
NC score	0.098426 (rank : 200)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	144	Target Neighborhood Hits	91	Shared Neighborhood Hits	62
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

RON_MOUSE
NC score	0.098331 (rank : 201)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	144	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ERBB3_HUMAN
NC score	0.098211 (rank : 202)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	144	Target Neighborhood Hits	918	Shared Neighborhood Hits	43
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB2_MOUSE
NC score	0.098161 (rank : 203)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	144	Target Neighborhood Hits	918	Shared Neighborhood Hits	43
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

INSRR_HUMAN
NC score	0.098144 (rank : 204)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	144	Target Neighborhood Hits	950	Shared Neighborhood Hits	43
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
NC score	0.098043 (rank : 205)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	144	Target Neighborhood Hits	961	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ERBB2_HUMAN
NC score	0.097988 (rank : 206)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	144	Target Neighborhood Hits	1073	Shared Neighborhood Hits	44
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB3_MOUSE
NC score	0.097961 (rank : 207)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	144	Target Neighborhood Hits	898	Shared Neighborhood Hits	43
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

NCF2_HUMAN
NC score	0.097915 (rank : 208)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	144	Target Neighborhood Hits	229	Shared Neighborhood Hits	49
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SOCS5_MOUSE
NC score	0.097909 (rank : 209)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	144	Target Neighborhood Hits	93	Shared Neighborhood Hits	61
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

EPHA6_HUMAN
NC score	0.097683 (rank : 210)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	144	Target Neighborhood Hits	959	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

UFO_HUMAN
NC score	0.097679 (rank : 211)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	144	Target Neighborhood Hits	981	Shared Neighborhood Hits	43
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ROR2_MOUSE
NC score	0.097665 (rank : 212)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	144	Target Neighborhood Hits	1000	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

AATK_HUMAN
NC score	0.097527 (rank : 213)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	144	Target Neighborhood Hits	1243	Shared Neighborhood Hits	45
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

FAK1_MOUSE
NC score	0.097514 (rank : 214)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ERBB4_HUMAN
NC score	0.097503 (rank : 215)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	144	Target Neighborhood Hits	910	Shared Neighborhood Hits	43
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EPHA6_MOUSE
NC score	0.097488 (rank : 216)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	144	Target Neighborhood Hits	946	Shared Neighborhood Hits	45
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FAK1_HUMAN
NC score	0.097476 (rank : 217)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	43
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

EPHA1_MOUSE
NC score	0.097085 (rank : 218)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	144	Target Neighborhood Hits	958	Shared Neighborhood Hits	45
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

INSR_HUMAN
NC score	0.096843 (rank : 219)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	144	Target Neighborhood Hits	963	Shared Neighborhood Hits	43
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

UFO_MOUSE
NC score	0.096681 (rank : 220)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	43
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

RON_HUMAN
NC score	0.096488 (rank : 221)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	144	Target Neighborhood Hits	842	Shared Neighborhood Hits	43
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DDR2_HUMAN
NC score	0.096459 (rank : 222)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	144	Target Neighborhood Hits	818	Shared Neighborhood Hits	43
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA5_MOUSE
NC score	0.096393 (rank : 223)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	144	Target Neighborhood Hits	950	Shared Neighborhood Hits	45
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

M3KL4_HUMAN
NC score	0.096387 (rank : 224)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	144	Target Neighborhood Hits	1087	Shared Neighborhood Hits	65
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

KIT_MOUSE
NC score	0.096370 (rank : 225)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	144	Target Neighborhood Hits	949	Shared Neighborhood Hits	43
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

INSR_MOUSE
NC score	0.096356 (rank : 226)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	144	Target Neighborhood Hits	968	Shared Neighborhood Hits	43
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

DDR2_MOUSE
NC score	0.096353 (rank : 227)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	144	Target Neighborhood Hits	813	Shared Neighborhood Hits	43
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

PGFRB_HUMAN
NC score	0.096208 (rank : 228)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	144	Target Neighborhood Hits	962	Shared Neighborhood Hits	43
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

NCF1_HUMAN
NC score	0.096195 (rank : 229)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

PGFRB_MOUSE
NC score	0.096146 (rank : 230)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	144	Target Neighborhood Hits	960	Shared Neighborhood Hits	43
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHA1_HUMAN
NC score	0.096068 (rank : 231)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	144	Target Neighborhood Hits	997	Shared Neighborhood Hits	45
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

PGFRA_MOUSE
NC score	0.095956 (rank : 232)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	144	Target Neighborhood Hits	975	Shared Neighborhood Hits	43
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

CSF1R_MOUSE
NC score	0.095890 (rank : 233)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	144	Target Neighborhood Hits	983	Shared Neighborhood Hits	43
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

RET_HUMAN
NC score	0.095818 (rank : 234)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	144	Target Neighborhood Hits	873	Shared Neighborhood Hits	43
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

KIT_HUMAN
NC score	0.095791 (rank : 235)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	144	Target Neighborhood Hits	953	Shared Neighborhood Hits	43
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PGFRA_HUMAN
NC score	0.095717 (rank : 236)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	144	Target Neighborhood Hits	980	Shared Neighborhood Hits	43
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

NTRK3_HUMAN
NC score	0.095620 (rank : 237)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	144	Target Neighborhood Hits	1115	Shared Neighborhood Hits	44
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

MET_MOUSE
NC score	0.095517 (rank : 238)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	144	Target Neighborhood Hits	844	Shared Neighborhood Hits	43
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

M3K11_HUMAN
NC score	0.095506 (rank : 239)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	144	Target Neighborhood Hits	1136	Shared Neighborhood Hits	65
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ROR2_HUMAN
NC score	0.095410 (rank : 240)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	144	Target Neighborhood Hits	1014	Shared Neighborhood Hits	43
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EGFR_HUMAN
NC score	0.095309 (rank : 241)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	144	Target Neighborhood Hits	939	Shared Neighborhood Hits	43
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
NC score	0.095294 (rank : 242)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	144	Target Neighborhood Hits	927	Shared Neighborhood Hits	43
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

RET_MOUSE
NC score	0.095087 (rank : 243)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	144	Target Neighborhood Hits	884	Shared Neighborhood Hits	43
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

MET_HUMAN
NC score	0.094992 (rank : 244)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	144	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

NCF1_MOUSE
NC score	0.094799 (rank : 245)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	144	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

EPHA2_HUMAN
NC score	0.094725 (rank : 246)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	144	Target Neighborhood Hits	1021	Shared Neighborhood Hits	45
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ROR1_MOUSE
NC score	0.094723 (rank : 247)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	144	Target Neighborhood Hits	1025	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

EPHA2_MOUSE
NC score	0.094702 (rank : 248)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	144	Target Neighborhood Hits	1020	Shared Neighborhood Hits	45
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

TYRO3_MOUSE
NC score	0.094626 (rank : 249)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	144	Target Neighborhood Hits	1007	Shared Neighborhood Hits	43
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ROR1_HUMAN
NC score	0.094526 (rank : 250)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	144	Target Neighborhood Hits	1018	Shared Neighborhood Hits	43
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TYRO3_HUMAN
NC score	0.094335 (rank : 251)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	144	Target Neighborhood Hits	995	Shared Neighborhood Hits	43
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

PACN2_HUMAN
NC score	0.094210 (rank : 252)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	144	Target Neighborhood Hits	339	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

EPHB3_MOUSE
NC score	0.094124 (rank : 253)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	144	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB3_HUMAN
NC score	0.094113 (rank : 254)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	144	Target Neighborhood Hits	996	Shared Neighborhood Hits	45
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHA8_MOUSE
NC score	0.094053 (rank : 255)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	144	Target Neighborhood Hits	969	Shared Neighborhood Hits	47
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FGFR4_MOUSE
NC score	0.093755 (rank : 256)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	144	Target Neighborhood Hits	1026	Shared Neighborhood Hits	43
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA8_HUMAN
NC score	0.093749 (rank : 257)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	144	Target Neighborhood Hits	956	Shared Neighborhood Hits	47
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB4_HUMAN
NC score	0.093468 (rank : 258)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	144	Target Neighborhood Hits	1056	Shared Neighborhood Hits	45
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

PACN1_HUMAN
NC score	0.093412 (rank : 259)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	144	Target Neighborhood Hits	320	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

EPHB2_HUMAN
NC score	0.093243 (rank : 260)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	144	Target Neighborhood Hits	983	Shared Neighborhood Hits	45
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
NC score	0.093166 (rank : 261)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	144	Target Neighborhood Hits	982	Shared Neighborhood Hits	45
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB4_MOUSE
NC score	0.093060 (rank : 262)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	144	Target Neighborhood Hits	1013	Shared Neighborhood Hits	45
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

SRC8_HUMAN
NC score	0.092867 (rank : 263)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	144	Target Neighborhood Hits	269	Shared Neighborhood Hits	52
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

EPHA4_MOUSE
NC score	0.092752 (rank : 264)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	144	Target Neighborhood Hits	982	Shared Neighborhood Hits	45
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ARHG6_MOUSE
NC score	0.092738 (rank : 265)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

EPHA4_HUMAN
NC score	0.092714 (rank : 266)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	144	Target Neighborhood Hits	975	Shared Neighborhood Hits	45
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA5_HUMAN
NC score	0.092584 (rank : 267)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	45
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PACN1_MOUSE
NC score	0.092161 (rank : 268)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	144	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

M3K9_HUMAN
NC score	0.092078 (rank : 269)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	144	Target Neighborhood Hits	1123	Shared Neighborhood Hits	65
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

FGFR4_HUMAN
NC score	0.091982 (rank : 270)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	144	Target Neighborhood Hits	1037	Shared Neighborhood Hits	43
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

NTRK2_MOUSE
NC score	0.091847 (rank : 271)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	144	Target Neighborhood Hits	1088	Shared Neighborhood Hits	43
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.091842 (rank : 272)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	144	Target Neighborhood Hits	1081	Shared Neighborhood Hits	43
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

EPHB1_HUMAN
NC score	0.091694 (rank : 273)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	144	Target Neighborhood Hits	988	Shared Neighborhood Hits	45
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

PACN2_MOUSE
NC score	0.091532 (rank : 274)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	144	Target Neighborhood Hits	382	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

M3K10_HUMAN
NC score	0.091453 (rank : 275)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	144	Target Neighborhood Hits	1071	Shared Neighborhood Hits	64
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

EPHA7_HUMAN
NC score	0.091398 (rank : 276)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	144	Target Neighborhood Hits	1053	Shared Neighborhood Hits	45
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.091265 (rank : 277)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	144	Target Neighborhood Hits	1025	Shared Neighborhood Hits	45
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA3_MOUSE
NC score	0.091014 (rank : 278)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	144	Target Neighborhood Hits	1009	Shared Neighborhood Hits	43
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

MUSK_MOUSE
NC score	0.090941 (rank : 279)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	144	Target Neighborhood Hits	1057	Shared Neighborhood Hits	43
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

TEX14_HUMAN
NC score	0.090937 (rank : 280)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

AHI1_HUMAN
NC score	0.090766 (rank : 281)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	144	Target Neighborhood Hits	537	Shared Neighborhood Hits	56
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

EPHA3_HUMAN
NC score	0.090757 (rank : 282)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	144	Target Neighborhood Hits	1005	Shared Neighborhood Hits	43
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

TIE1_HUMAN
NC score	0.090683 (rank : 283)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	144	Target Neighborhood Hits	1241	Shared Neighborhood Hits	43
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

MUSK_HUMAN
NC score	0.090633 (rank : 284)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	144	Target Neighborhood Hits	1074	Shared Neighborhood Hits	43
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MLKL_HUMAN
NC score	0.090602 (rank : 285)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	144	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

NUMBL_MOUSE
NC score	0.090590 (rank : 286)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	144	Target Neighborhood Hits	147	Shared Neighborhood Hits	11
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

TIE1_MOUSE
NC score	0.090435 (rank : 287)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	144	Target Neighborhood Hits	1266	Shared Neighborhood Hits	43
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

AB1IP_HUMAN
NC score	0.090263 (rank : 288)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	144	Target Neighborhood Hits	213	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

PACN3_MOUSE
NC score	0.090149 (rank : 289)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	144	Target Neighborhood Hits	380	Shared Neighborhood Hits	55
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

JAK1_MOUSE
NC score	0.089867 (rank : 290)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	144	Target Neighborhood Hits	854	Shared Neighborhood Hits	50
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

SRC8_MOUSE
NC score	0.089863 (rank : 291)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	144	Target Neighborhood Hits	292	Shared Neighborhood Hits	52
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

FGFR3_HUMAN
NC score	0.089830 (rank : 292)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	144	Target Neighborhood Hits	1042	Shared Neighborhood Hits	43
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ES8L3_HUMAN
NC score	0.089737 (rank : 293)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	144	Target Neighborhood Hits	206	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

HCLS1_HUMAN
NC score	0.089606 (rank : 294)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	144	Target Neighborhood Hits	358	Shared Neighborhood Hits	46
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

TIE2_HUMAN
NC score	0.089605 (rank : 295)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	144	Target Neighborhood Hits	1192	Shared Neighborhood Hits	43
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TEX14_MOUSE
NC score	0.089565 (rank : 296)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	144	Target Neighborhood Hits	1333	Shared Neighborhood Hits	45
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TIE2_MOUSE
NC score	0.089552 (rank : 297)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	144	Target Neighborhood Hits	1204	Shared Neighborhood Hits	43
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

AB1IP_MOUSE
NC score	0.089420 (rank : 298)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	144	Target Neighborhood Hits	181	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

FGFR3_MOUSE
NC score	0.089370 (rank : 299)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	144	Target Neighborhood Hits	1059	Shared Neighborhood Hits	43
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

VGFR3_HUMAN
NC score	0.089238 (rank : 300)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	144	Target Neighborhood Hits	1037	Shared Neighborhood Hits	43
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR2_MOUSE
NC score	0.089220 (rank : 301)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	144	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

MLKL_MOUSE
NC score	0.088993 (rank : 302)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	144	Target Neighborhood Hits	707	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ILK_MOUSE
NC score	0.088926 (rank : 303)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	144	Target Neighborhood Hits	858	Shared Neighborhood Hits	45
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ABI2_MOUSE
NC score	0.088871 (rank : 304)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	144	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

FGFR2_HUMAN
NC score	0.088819 (rank : 305)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	144	Target Neighborhood Hits	1062	Shared Neighborhood Hits	43
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

JAK1_HUMAN
NC score	0.088790 (rank : 306)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	144	Target Neighborhood Hits	858	Shared Neighborhood Hits	49
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ABI2_HUMAN
NC score	0.088756 (rank : 307)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	144	Target Neighborhood Hits	350	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

VGFR3_MOUSE
NC score	0.088708 (rank : 308)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	144	Target Neighborhood Hits	1056	Shared Neighborhood Hits	43
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.088587 (rank : 309)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	144	Target Neighborhood Hits	1068	Shared Neighborhood Hits	43
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.088575 (rank : 310)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	144	Target Neighborhood Hits	1069	Shared Neighborhood Hits	43
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

AHI1_MOUSE
NC score	0.088405 (rank : 311)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	144	Target Neighborhood Hits	496	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SPN90_HUMAN
NC score	0.088220 (rank : 312)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

PACN3_HUMAN
NC score	0.088192 (rank : 313)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	144	Target Neighborhood Hits	385	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

HCLS1_MOUSE
NC score	0.088143 (rank : 314)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	144	Target Neighborhood Hits	329	Shared Neighborhood Hits	47
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

TENS4_MOUSE
NC score	0.088086 (rank : 315)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	144	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

ILK1_HUMAN
NC score	0.088016 (rank : 316)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	144	Target Neighborhood Hits	857	Shared Neighborhood Hits	45
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

PTK7_HUMAN
NC score	0.087575 (rank : 317)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	43
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

GUC2F_HUMAN
NC score	0.087446 (rank : 318)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	144	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ILK2_HUMAN
NC score	0.087244 (rank : 319)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	144	Target Neighborhood Hits	848	Shared Neighborhood Hits	45
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ABI3_HUMAN
NC score	0.087235 (rank : 320)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

VGFR2_HUMAN
NC score	0.086764 (rank : 321)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	144	Target Neighborhood Hits	1103	Shared Neighborhood Hits	45
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
NC score	0.086669 (rank : 322)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	144	Target Neighborhood Hits	1089	Shared Neighborhood Hits	43
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

TYK2_MOUSE
NC score	0.085764 (rank : 323)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	144	Target Neighborhood Hits	850	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JIP1_MOUSE
NC score	0.085670 (rank : 324)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	144	Target Neighborhood Hits	259	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JAK3_HUMAN
NC score	0.085637 (rank : 325)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	144	Target Neighborhood Hits	827	Shared Neighborhood Hits	43
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

ANPRA_HUMAN
NC score	0.085425 (rank : 326)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	144	Target Neighborhood Hits	612	Shared Neighborhood Hits	43
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.085353 (rank : 327)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	144	Target Neighborhood Hits	600	Shared Neighborhood Hits	43
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ES8L3_MOUSE
NC score	0.085178 (rank : 328)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	144	Target Neighborhood Hits	168	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CIP4_HUMAN
NC score	0.085061 (rank : 329)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	144	Target Neighborhood Hits	374	Shared Neighborhood Hits	38
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

VGFR1_HUMAN
NC score	0.084484 (rank : 330)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	144	Target Neighborhood Hits	1109	Shared Neighborhood Hits	43
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

GUC2C_HUMAN
NC score	0.084191 (rank : 331)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	144	Target Neighborhood Hits	624	Shared Neighborhood Hits	43
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

VGFR1_MOUSE
NC score	0.084087 (rank : 332)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	144	Target Neighborhood Hits	1118	Shared Neighborhood Hits	43
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

JIP1_HUMAN
NC score	0.084066 (rank : 333)	θ value	1.06291 (rank : 123)
Query Neighborhood Hits	144	Target Neighborhood Hits	271	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

TYK2_HUMAN
NC score	0.084030 (rank : 334)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	144	Target Neighborhood Hits	841	Shared Neighborhood Hits	43
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK2_MOUSE
NC score	0.083707 (rank : 335)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	144	Target Neighborhood Hits	839	Shared Neighborhood Hits	46
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_HUMAN
NC score	0.082949 (rank : 336)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

ITSN2_HUMAN
NC score	0.082843 (rank : 337)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	144	Target Neighborhood Hits	1173	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

JAK3_MOUSE
NC score	0.082424 (rank : 338)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	144	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

BRAF1_HUMAN
NC score	0.082406 (rank : 339)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	144	Target Neighborhood Hits	883	Shared Neighborhood Hits	52
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RAF1_HUMAN
NC score	0.081748 (rank : 340)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	144	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TENS4_HUMAN
NC score	0.081547 (rank : 341)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	144	Target Neighborhood Hits	214	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

ARAF_MOUSE
NC score	0.081522 (rank : 342)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARAF_HUMAN
NC score	0.081364 (rank : 343)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	144	Target Neighborhood Hits	924	Shared Neighborhood Hits	51
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

RAF1_MOUSE
NC score	0.081316 (rank : 344)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	144	Target Neighborhood Hits	886	Shared Neighborhood Hits	51
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RHG04_HUMAN
NC score	0.081093 (rank : 345)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ANM2_HUMAN
NC score	0.080519 (rank : 346)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	144	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRB_MOUSE
NC score	0.080193 (rank : 347)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	144	Target Neighborhood Hits	607	Shared Neighborhood Hits	43
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

SPN90_MOUSE
NC score	0.080102 (rank : 348)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SH3G3_MOUSE
NC score	0.080088 (rank : 349)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	144	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

ANPRB_HUMAN
NC score	0.079812 (rank : 350)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	144	Target Neighborhood Hits	646	Shared Neighborhood Hits	43
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

MLTK_HUMAN
NC score	0.079734 (rank : 351)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	144	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
NC score	0.079693 (rank : 352)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

IRAK3_MOUSE
NC score	0.079288 (rank : 353)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	144	Target Neighborhood Hits	628	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

APBA3_MOUSE
NC score	0.079224 (rank : 354)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	144	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SH3G2_HUMAN
NC score	0.079022 (rank : 355)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	51
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NUMBL_HUMAN
NC score	0.078823 (rank : 356)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	144	Target Neighborhood Hits	394	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

ARHG4_HUMAN
NC score	0.078653 (rank : 357)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	144	Target Neighborhood Hits	242	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

LASP1_HUMAN
NC score	0.078620 (rank : 358)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	144	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MOS_HUMAN
NC score	0.078503 (rank : 359)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	144	Target Neighborhood Hits	829	Shared Neighborhood Hits	43
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ABI1_MOUSE
NC score	0.077979 (rank : 360)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	144	Target Neighborhood Hits	246	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

RIPK1_MOUSE
NC score	0.077942 (rank : 361)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

IRAK1_MOUSE
NC score	0.077938 (rank : 362)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	144	Target Neighborhood Hits	784	Shared Neighborhood Hits	45
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

ITSN2_MOUSE
NC score	0.077936 (rank : 363)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	144	Target Neighborhood Hits	1371	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LASP1_MOUSE
NC score	0.077618 (rank : 364)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	144	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

KSR2_HUMAN
NC score	0.077407 (rank : 365)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	144	Target Neighborhood Hits	920	Shared Neighborhood Hits	47
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

ES8L1_HUMAN
NC score	0.077232 (rank : 366)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	144	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

IRAK3_HUMAN
NC score	0.077216 (rank : 367)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	144	Target Neighborhood Hits	644	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MOS_MOUSE
NC score	0.077194 (rank : 368)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

KSR1_HUMAN
NC score	0.077184 (rank : 369)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

GUC2G_MOUSE
NC score	0.077143 (rank : 370)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	144	Target Neighborhood Hits	644	Shared Neighborhood Hits	40
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

RIPK1_HUMAN
NC score	0.076936 (rank : 371)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	144	Target Neighborhood Hits	891	Shared Neighborhood Hits	43
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

SOCS4_HUMAN
NC score	0.076661 (rank : 372)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	144	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

KSR1_MOUSE
NC score	0.076349 (rank : 373)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	144	Target Neighborhood Hits	870	Shared Neighborhood Hits	46
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

NEBL_HUMAN
NC score	0.076226 (rank : 374)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	144	Target Neighborhood Hits	457	Shared Neighborhood Hits	49
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

GUC2E_MOUSE
NC score	0.076145 (rank : 375)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	144	Target Neighborhood Hits	692	Shared Neighborhood Hits	43
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

SH3G1_MOUSE
NC score	0.076124 (rank : 376)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	144	Target Neighborhood Hits	291	Shared Neighborhood Hits	49
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

DBNL_HUMAN
NC score	0.075989 (rank : 377)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	144	Target Neighborhood Hits	244	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

ES8L2_HUMAN
NC score	0.075862 (rank : 378)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	144	Target Neighborhood Hits	193	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SOCS4_MOUSE
NC score	0.075832 (rank : 379)	θ value	5.27518 (rank : 141)
Query Neighborhood Hits	144	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

ABI3_MOUSE
NC score	0.075811 (rank : 380)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	144	Target Neighborhood Hits	227	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ES8L2_MOUSE
NC score	0.075710 (rank : 381)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	144	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

GUC2D_HUMAN
NC score	0.075702 (rank : 382)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

SH3G3_HUMAN
NC score	0.075539 (rank : 383)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	144	Target Neighborhood Hits	222	Shared Neighborhood Hits	45
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SRGP2_HUMAN
NC score	0.075296 (rank : 384)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	144	Target Neighborhood Hits	331	Shared Neighborhood Hits	54
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ANM2_MOUSE
NC score	0.075174 (rank : 385)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	144	Target Neighborhood Hits	175	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ITSN1_HUMAN
NC score	0.075075 (rank : 386)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	144	Target Neighborhood Hits	1757	Shared Neighborhood Hits	66
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

M3K12_HUMAN
NC score	0.074970 (rank : 387)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	144	Target Neighborhood Hits	940	Shared Neighborhood Hits	43
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

BMR1B_HUMAN
NC score	0.074964 (rank : 388)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	144	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

M3K12_MOUSE
NC score	0.074963 (rank : 389)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	144	Target Neighborhood Hits	957	Shared Neighborhood Hits	44
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

DBNL_MOUSE
NC score	0.074932 (rank : 390)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	144	Target Neighborhood Hits	306	Shared Neighborhood Hits	45
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

BMR1B_MOUSE
NC score	0.074840 (rank : 391)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	144	Target Neighborhood Hits	758	Shared Neighborhood Hits	43
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

M3K13_HUMAN
NC score	0.074801 (rank : 392)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	144	Target Neighborhood Hits	911	Shared Neighborhood Hits	43
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

PEX13_HUMAN
NC score	0.074537 (rank : 393)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	144	Target Neighborhood Hits	128	Shared Neighborhood Hits	30
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ITSN1_MOUSE
NC score	0.074521 (rank : 394)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	144	Target Neighborhood Hits	1669	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ABI1_HUMAN
NC score	0.074319 (rank : 395)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	144	Target Neighborhood Hits	257	Shared Neighborhood Hits	46
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

RIPK2_MOUSE
NC score	0.073997 (rank : 396)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	144	Target Neighborhood Hits	776	Shared Neighborhood Hits	43
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

SRGP2_MOUSE
NC score	0.073994 (rank : 397)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	144	Target Neighborhood Hits	324	Shared Neighborhood Hits	53
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SH3G1_HUMAN
NC score	0.073985 (rank : 398)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	144	Target Neighborhood Hits	307	Shared Neighborhood Hits	46
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

IRAK1_HUMAN
NC score	0.073533 (rank : 399)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	144	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

RIPK3_MOUSE
NC score	0.073106 (rank : 400)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

M3K7_MOUSE
NC score	0.073041 (rank : 401)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	144	Target Neighborhood Hits	892	Shared Neighborhood Hits	45
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

BMR1A_MOUSE
NC score	0.073016 (rank : 402)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	144	Target Neighborhood Hits	758	Shared Neighborhood Hits	43
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

M3K7_HUMAN
NC score	0.073007 (rank : 403)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	144	Target Neighborhood Hits	892	Shared Neighborhood Hits	45
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

BMR1A_HUMAN
NC score	0.072927 (rank : 404)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	144	Target Neighborhood Hits	759	Shared Neighborhood Hits	43
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

RIPK2_HUMAN
NC score	0.072425 (rank : 405)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	144	Target Neighborhood Hits	774	Shared Neighborhood Hits	43
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK3_HUMAN
NC score	0.072240 (rank : 406)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	144	Target Neighborhood Hits	828	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RAPH1_HUMAN
NC score	0.072089 (rank : 407)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	144	Target Neighborhood Hits	593	Shared Neighborhood Hits	16
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

TNI3K_MOUSE
NC score	0.072076 (rank : 408)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	144	Target Neighborhood Hits	1079	Shared Neighborhood Hits	45
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

APBA2_HUMAN
NC score	0.071988 (rank : 409)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	144	Target Neighborhood Hits	220	Shared Neighborhood Hits	10
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

SH3G2_MOUSE
NC score	0.071862 (rank : 410)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	144	Target Neighborhood Hits	319	Shared Neighborhood Hits	45
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

TNI3K_HUMAN
NC score	0.071645 (rank : 411)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	144	Target Neighborhood Hits	1084	Shared Neighborhood Hits	45
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

FNBP2_HUMAN
NC score	0.071154 (rank : 412)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	144	Target Neighborhood Hits	432	Shared Neighborhood Hits	52
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

IRAK4_HUMAN
NC score	0.070704 (rank : 413)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	144	Target Neighborhood Hits	816	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

TESK2_HUMAN
NC score	0.070660 (rank : 414)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	45
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LIMK1_MOUSE
NC score	0.070084 (rank : 415)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	144	Target Neighborhood Hits	1008	Shared Neighborhood Hits	44
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LIMK1_HUMAN
NC score	0.070083 (rank : 416)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	144	Target Neighborhood Hits	1005	Shared Neighborhood Hits	44
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

SRGP1_HUMAN
NC score	0.069994 (rank : 417)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	144	Target Neighborhood Hits	390	Shared Neighborhood Hits	52
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TESK2_MOUSE
NC score	0.069673 (rank : 418)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TOPK_MOUSE
NC score	0.068602 (rank : 419)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	144	Target Neighborhood Hits	618	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TOPK_HUMAN
NC score	0.068588 (rank : 420)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	144	Target Neighborhood Hits	605	Shared Neighborhood Hits	43
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

IRAK4_MOUSE
NC score	0.068493 (rank : 421)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	144	Target Neighborhood Hits	820	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

APBA1_HUMAN
NC score	0.068485 (rank : 422)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	144	Target Neighborhood Hits	325	Shared Neighborhood Hits	10
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

TESK1_HUMAN
NC score	0.068296 (rank : 423)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	45
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

RIPK5_HUMAN
NC score	0.068196 (rank : 424)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

LIMK2_MOUSE
NC score	0.068191 (rank : 425)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	144	Target Neighborhood Hits	998	Shared Neighborhood Hits	43
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_HUMAN
NC score	0.068186 (rank : 426)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	144	Target Neighborhood Hits	986	Shared Neighborhood Hits	43
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

RIPK5_MOUSE
NC score	0.068100 (rank : 427)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

APBA2_MOUSE
NC score	0.068051 (rank : 428)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	144	Target Neighborhood Hits	219	Shared Neighborhood Hits	11
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

TGFR1_HUMAN
NC score	0.067843 (rank : 429)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	144	Target Neighborhood Hits	755	Shared Neighborhood Hits	43
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.067757 (rank : 430)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TESK1_MOUSE
NC score	0.067708 (rank : 431)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	144	Target Neighborhood Hits	862	Shared Neighborhood Hits	43
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ACVL1_MOUSE
NC score	0.067629 (rank : 432)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	144	Target Neighborhood Hits	739	Shared Neighborhood Hits	43
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_HUMAN
NC score	0.067578 (rank : 433)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	144	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

TENS1_HUMAN
NC score	0.067282 (rank : 434)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	144	Target Neighborhood Hits	400	Shared Neighborhood Hits	69
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

PEX13_MOUSE
NC score	0.067208 (rank : 435)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	144	Target Neighborhood Hits	126	Shared Neighborhood Hits	32
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

ACV1C_HUMAN
NC score	0.067097 (rank : 436)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

IRAK2_HUMAN
NC score	0.067058 (rank : 437)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	144	Target Neighborhood Hits	714	Shared Neighborhood Hits	40
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ACV1C_MOUSE
NC score	0.066808 (rank : 438)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1B_MOUSE
NC score	0.066731 (rank : 439)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.066649 (rank : 440)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	144	Target Neighborhood Hits	753	Shared Neighborhood Hits	43
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

EPS8_MOUSE
NC score	0.065936 (rank : 441)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	144	Target Neighborhood Hits	157	Shared Neighborhood Hits	44
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ANKK1_MOUSE
NC score	0.065400 (rank : 442)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	144	Target Neighborhood Hits	1072	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANKK1_HUMAN
NC score	0.064964 (rank : 443)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	144	Target Neighborhood Hits	1075	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

EPS8_HUMAN
NC score	0.064851 (rank : 444)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	144	Target Neighborhood Hits	151	Shared Neighborhood Hits	41
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

IASPP_HUMAN
NC score	0.064494 (rank : 445)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	144	Target Neighborhood Hits	688	Shared Neighborhood Hits	50
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RIPK4_HUMAN
NC score	0.064472 (rank : 446)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	144	Target Neighborhood Hits	1094	Shared Neighborhood Hits	45
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ES8L1_MOUSE
NC score	0.064051 (rank : 447)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	144	Target Neighborhood Hits	143	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ARHG9_HUMAN
NC score	0.063906 (rank : 448)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	37
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.063865 (rank : 449)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	144	Target Neighborhood Hits	234	Shared Neighborhood Hits	37
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ACVR1_MOUSE
NC score	0.063279 (rank : 450)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	144	Target Neighborhood Hits	768	Shared Neighborhood Hits	43
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

LRRK1_MOUSE
NC score	0.063067 (rank : 451)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	144	Target Neighborhood Hits	1267	Shared Neighborhood Hits	46
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_HUMAN
NC score	0.063029 (rank : 452)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	144	Target Neighborhood Hits	1237	Shared Neighborhood Hits	46
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ACVR1_HUMAN
NC score	0.062872 (rank : 453)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	144	Target Neighborhood Hits	760	Shared Neighborhood Hits	43
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

NCF4_MOUSE
NC score	0.062294 (rank : 454)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	144	Target Neighborhood Hits	177	Shared Neighborhood Hits	31
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

AMHR2_HUMAN
NC score	0.061952 (rank : 455)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	144	Target Neighborhood Hits	715	Shared Neighborhood Hits	43
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

LRRK2_HUMAN
NC score	0.059934 (rank : 456)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	144	Target Neighborhood Hits	1382	Shared Neighborhood Hits	44
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

ARH_MOUSE
NC score	0.059543 (rank : 457)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	144	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

LRRK2_MOUSE
NC score	0.059388 (rank : 458)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	144	Target Neighborhood Hits	1359	Shared Neighborhood Hits	44
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

NEBU_HUMAN
NC score	0.059365 (rank : 459)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	144	Target Neighborhood Hits	420	Shared Neighborhood Hits	46
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

IASPP_MOUSE
NC score	0.059313 (rank : 460)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	144	Target Neighborhood Hits	1024	Shared Neighborhood Hits	54
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ARHG4_MOUSE
NC score	0.058884 (rank : 461)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	144	Target Neighborhood Hits	185	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BMPR2_HUMAN
NC score	0.057890 (rank : 462)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	144	Target Neighborhood Hits	736	Shared Neighborhood Hits	43
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
NC score	0.057847 (rank : 463)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	144	Target Neighborhood Hits	738	Shared Neighborhood Hits	43
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BCAR1_MOUSE
NC score	0.057100 (rank : 464)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	144	Target Neighborhood Hits	438	Shared Neighborhood Hits	51
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CI096_HUMAN
NC score	0.057035 (rank : 465)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	144	Target Neighborhood Hits	821	Shared Neighborhood Hits	43
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

NOXO1_MOUSE
NC score	0.057031 (rank : 466)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	144	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NEK11_MOUSE
NC score	0.057003 (rank : 467)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	144	Target Neighborhood Hits	875	Shared Neighborhood Hits	44
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK39_MOUSE
NC score	0.056626 (rank : 468)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	144	Target Neighborhood Hits	915	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK39_HUMAN
NC score	0.056584 (rank : 469)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	144	Target Neighborhood Hits	882	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

OXSR1_MOUSE
NC score	0.056536 (rank : 470)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	144	Target Neighborhood Hits	865	Shared Neighborhood Hits	43
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

APBA3_HUMAN
NC score	0.056495 (rank : 471)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	144	Target Neighborhood Hits	201	Shared Neighborhood Hits	10
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

OXSR1_HUMAN
NC score	0.056449 (rank : 472)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	144	Target Neighborhood Hits	874	Shared Neighborhood Hits	43
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

NEK11_HUMAN
NC score	0.056260 (rank : 473)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	144	Target Neighborhood Hits	1043	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

EFS_MOUSE
NC score	0.056140 (rank : 474)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	144	Target Neighborhood Hits	389	Shared Neighborhood Hits	44
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

KC1D_HUMAN
NC score	0.055830 (rank : 475)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	144	Target Neighborhood Hits	737	Shared Neighborhood Hits	41
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.055829 (rank : 476)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	144	Target Neighborhood Hits	737	Shared Neighborhood Hits	41
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

BCAR1_HUMAN
NC score	0.054407 (rank : 477)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	144	Target Neighborhood Hits	554	Shared Neighborhood Hits	51
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STK24_MOUSE
NC score	0.053937 (rank : 478)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	144	Target Neighborhood Hits	856	Shared Neighborhood Hits	43
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

CT032_HUMAN
NC score	0.053779 (rank : 479)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	144	Target Neighborhood Hits	235	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

KC1E_MOUSE
NC score	0.053693 (rank : 480)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	144	Target Neighborhood Hits	728	Shared Neighborhood Hits	41
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_HUMAN
NC score	0.053691 (rank : 481)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	144	Target Neighborhood Hits	732	Shared Neighborhood Hits	41
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

YSK4_HUMAN
NC score	0.053652 (rank : 482)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	144	Target Neighborhood Hits	921	Shared Neighborhood Hits	44
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

RUSC1_HUMAN
NC score	0.053605 (rank : 483)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	144	Target Neighborhood Hits	226	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

STK24_HUMAN
NC score	0.053496 (rank : 484)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	144	Target Neighborhood Hits	853	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

MST4_HUMAN
NC score	0.053465 (rank : 485)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	144	Target Neighborhood Hits	852	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK16_MOUSE
NC score	0.053461 (rank : 486)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	144	Target Neighborhood Hits	824	Shared Neighborhood Hits	43
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

ASPP1_HUMAN
NC score	0.053439 (rank : 487)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	144	Target Neighborhood Hits	956	Shared Neighborhood Hits	39
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MST4_MOUSE
NC score	0.053354 (rank : 488)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	144	Target Neighborhood Hits	860	Shared Neighborhood Hits	43
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

SHAN2_MOUSE
NC score	0.053295 (rank : 489)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	144	Target Neighborhood Hits	446	Shared Neighborhood Hits	42
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

NEK6_MOUSE
NC score	0.053286 (rank : 490)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK6_HUMAN
NC score	0.053152 (rank : 491)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	144	Target Neighborhood Hits	848	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

RHG26_HUMAN
NC score	0.052975 (rank : 492)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	144	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

NEK7_HUMAN
NC score	0.052810 (rank : 493)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	144	Target Neighborhood Hits	846	Shared Neighborhood Hits	43
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_MOUSE
NC score	0.052640 (rank : 494)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	144	Target Neighborhood Hits	847	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

EFS_HUMAN
NC score	0.052478 (rank : 495)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	144	Target Neighborhood Hits	348	Shared Neighborhood Hits	41
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

STK16_HUMAN
NC score	0.052393 (rank : 496)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	144	Target Neighborhood Hits	824	Shared Neighborhood Hits	43
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK25_MOUSE
NC score	0.052296 (rank : 497)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	144	Target Neighborhood Hits	851	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

E2AK2_MOUSE
NC score	0.052033 (rank : 498)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	144	Target Neighborhood Hits	864	Shared Neighborhood Hits	43
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

STK25_HUMAN
NC score	0.052030 (rank : 499)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	144	Target Neighborhood Hits	853	Shared Neighborhood Hits	43
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MP2K5_MOUSE
NC score	0.051921 (rank : 500)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	144	Target Neighborhood Hits	840	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MYLK2_HUMAN
NC score	0.051873 (rank : 501)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	144	Target Neighborhood Hits	920	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

AL2S2_MOUSE
NC score	0.051760 (rank : 502)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	144	Target Neighborhood Hits	709	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

KPCD_HUMAN
NC score	0.051714 (rank : 503)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	144	Target Neighborhood Hits	900	Shared Neighborhood Hits	52
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

IKKA_HUMAN
NC score	0.051370 (rank : 504)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	144	Target Neighborhood Hits	863	Shared Neighborhood Hits	43
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MP2K2_MOUSE
NC score	0.051364 (rank : 505)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	144	Target Neighborhood Hits	828	Shared Neighborhood Hits	43
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_HUMAN
NC score	0.051309 (rank : 506)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	144	Target Neighborhood Hits	830	Shared Neighborhood Hits	43
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

AVR2A_MOUSE
NC score	0.051203 (rank : 507)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	144	Target Neighborhood Hits	767	Shared Neighborhood Hits	43
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.051201 (rank : 508)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	144	Target Neighborhood Hits	767	Shared Neighborhood Hits	43
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

KPCD_MOUSE
NC score	0.051120 (rank : 509)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	144	Target Neighborhood Hits	888	Shared Neighborhood Hits	52
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

AL2S7_HUMAN
NC score	0.050916 (rank : 510)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	144	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ASPP1_MOUSE
NC score	0.050769 (rank : 511)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	144	Target Neighborhood Hits	1244	Shared Neighborhood Hits	43
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

KPCT_HUMAN
NC score	0.050668 (rank : 512)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	144	Target Neighborhood Hits	897	Shared Neighborhood Hits	52
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

IKKA_MOUSE
NC score	0.050626 (rank : 513)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MP2K7_HUMAN
NC score	0.050548 (rank : 514)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	144	Target Neighborhood Hits	833	Shared Neighborhood Hits	43
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

KPCB_MOUSE
NC score	0.050436 (rank : 515)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	144	Target Neighborhood Hits	1117	Shared Neighborhood Hits	54
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

NEK4_MOUSE
NC score	0.050394 (rank : 516)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	144	Target Neighborhood Hits	899	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

AL2S2_HUMAN
NC score	0.050320 (rank : 517)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	144	Target Neighborhood Hits	727	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

ICK_MOUSE
NC score	0.050308 (rank : 518)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	144	Target Neighborhood Hits	860	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ICK_HUMAN
NC score	0.050218 (rank : 519)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	144	Target Neighborhood Hits	867	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TAOK2_HUMAN
NC score	0.050212 (rank : 520)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	144	Target Neighborhood Hits	1172	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

SPTA2_HUMAN
NC score	0.050187 (rank : 521)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	144	Target Neighborhood Hits	888	Shared Neighborhood Hits	53
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

AVR2B_HUMAN
NC score	0.050158 (rank : 522)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	144	Target Neighborhood Hits	748	Shared Neighborhood Hits	43
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

TSSK4_HUMAN
NC score	0.050078 (rank : 523)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	144	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

MAK_MOUSE
NC score	0.050056 (rank : 524)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	144	Target Neighborhood Hits	873	Shared Neighborhood Hits	43
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

KPCB_HUMAN
NC score	0.050022 (rank : 525)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	144	Target Neighborhood Hits	1121	Shared Neighborhood Hits	54
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

AVR2B_MOUSE
NC score	0.050002 (rank : 526)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	144	Target Neighborhood Hits	749	Shared Neighborhood Hits	43
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

JIP2_HUMAN
NC score	0.048785 (rank : 527)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	144	Target Neighborhood Hits	288	Shared Neighborhood Hits	13
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

SH2D5_HUMAN
NC score	0.046834 (rank : 528)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	144	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZV89, Q5SSJ2	Gene names	SH2D5
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 5.

RPB1_HUMAN
NC score	0.016553 (rank : 529)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	144	Target Neighborhood Hits	362	Shared Neighborhood Hits	5
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
NC score	0.016526 (rank : 530)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	144	Target Neighborhood Hits	363	Shared Neighborhood Hits	5
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SETB1_MOUSE
NC score	0.014417 (rank : 531)	θ value	1.38821 (rank : 125)
Query Neighborhood Hits	144	Target Neighborhood Hits	150	Shared Neighborhood Hits	2
SwissProt Accessions	O88974, Q922K1	Gene names	Setdb1, Eset
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SPB11_HUMAN
NC score	0.002312 (rank : 532)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	144	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q96P15, Q96P13, Q96P14	Gene names	SERPINB11
Domain Architecture
Description	Serpin B11.

LGR4_HUMAN
NC score	0.001234 (rank : 533)	θ value	1.38821 (rank : 124)
Query Neighborhood Hits	144	Target Neighborhood Hits	481	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).