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Network neighborhood for query Sequence : JIP1_HUMAN

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JIP1_HUMAN
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

JIP1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	271
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	0 (rank : 2)	NC score	0.970664 (rank : 2)
Query Neighborhood Hits	271	Target Neighborhood Hits	259	Shared Neighborhood Hits	183
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	1.94955e-95 (rank : 3)	NC score	0.837558 (rank : 4)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	89
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	1.26366e-94 (rank : 4)	NC score	0.845016 (rank : 3)
Query Neighborhood Hits	271	Target Neighborhood Hits	144	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

VINEX_MOUSE
θ value	0.000270298 (rank : 5)	NC score	0.236230 (rank : 5)
Query Neighborhood Hits	271	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
θ value	0.00035302 (rank : 6)	NC score	0.232740 (rank : 8)
Query Neighborhood Hits	271	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NUMBL_HUMAN
θ value	0.000461057 (rank : 7)	NC score	0.233743 (rank : 7)
Query Neighborhood Hits	271	Target Neighborhood Hits	394	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUMBL_MOUSE
θ value	0.000461057 (rank : 8)	NC score	0.228240 (rank : 9)
Query Neighborhood Hits	271	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

CIC_HUMAN
θ value	0.000602161 (rank : 9)	NC score	0.127920 (rank : 25)
Query Neighborhood Hits	271	Target Neighborhood Hits	992	Shared Neighborhood Hits	100
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

ANKS1_HUMAN
θ value	0.00175202 (rank : 10)	NC score	0.106519 (rank : 51)
Query Neighborhood Hits	271	Target Neighborhood Hits	438	Shared Neighborhood Hits	35
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0.00175202 (rank : 11)	NC score	0.113727 (rank : 40)
Query Neighborhood Hits	271	Target Neighborhood Hits	453	Shared Neighborhood Hits	37
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ARHG5_HUMAN
θ value	0.00228821 (rank : 12)	NC score	0.143045 (rank : 21)
Query Neighborhood Hits	271	Target Neighborhood Hits	172	Shared Neighborhood Hits	54
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

CAPON_MOUSE
θ value	0.00228821 (rank : 13)	NC score	0.207792 (rank : 14)
Query Neighborhood Hits	271	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

AKAP1_MOUSE
θ value	0.00298849 (rank : 14)	NC score	0.101739 (rank : 60)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

RGS3_MOUSE
θ value	0.00298849 (rank : 15)	NC score	0.127316 (rank : 26)
Query Neighborhood Hits	271	Target Neighborhood Hits	1621	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ARH_HUMAN
θ value	0.00390308 (rank : 16)	NC score	0.224156 (rank : 10)
Query Neighborhood Hits	271	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

CAPON_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.214949 (rank : 12)
Query Neighborhood Hits	271	Target Neighborhood Hits	35	Shared Neighborhood Hits	18
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

APBB2_HUMAN
θ value	0.00509761 (rank : 18)	NC score	0.120677 (rank : 30)
Query Neighborhood Hits	271	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

SRBS1_MOUSE
θ value	0.00509761 (rank : 19)	NC score	0.212137 (rank : 13)
Query Neighborhood Hits	271	Target Neighborhood Hits	409	Shared Neighborhood Hits	74
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NUMB_HUMAN
θ value	0.00665767 (rank : 20)	NC score	0.203664 (rank : 16)
Query Neighborhood Hits	271	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.204153 (rank : 15)
Query Neighborhood Hits	271	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

SRBS1_HUMAN
θ value	0.00665767 (rank : 22)	NC score	0.216395 (rank : 11)
Query Neighborhood Hits	271	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

APBB2_MOUSE
θ value	0.00869519 (rank : 23)	NC score	0.115746 (rank : 37)
Query Neighborhood Hits	271	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

ARH_MOUSE
θ value	0.00869519 (rank : 24)	NC score	0.236031 (rank : 6)
Query Neighborhood Hits	271	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

PPIP1_MOUSE
θ value	0.0113563 (rank : 25)	NC score	0.148958 (rank : 20)
Query Neighborhood Hits	271	Target Neighborhood Hits	377	Shared Neighborhood Hits	59
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

STS2_HUMAN
θ value	0.0113563 (rank : 26)	NC score	0.198592 (rank : 17)
Query Neighborhood Hits	271	Target Neighborhood Hits	108	Shared Neighborhood Hits	44
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

SYN1_HUMAN
θ value	0.0113563 (rank : 27)	NC score	0.111969 (rank : 43)
Query Neighborhood Hits	271	Target Neighborhood Hits	419	Shared Neighborhood Hits	45
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

PPIP1_HUMAN
θ value	0.0148317 (rank : 28)	NC score	0.152944 (rank : 18)
Query Neighborhood Hits	271	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CELR2_HUMAN
θ value	0.0193708 (rank : 29)	NC score	0.018750 (rank : 331)
Query Neighborhood Hits	271	Target Neighborhood Hits	657	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

CIC_MOUSE
θ value	0.0193708 (rank : 30)	NC score	0.104954 (rank : 54)
Query Neighborhood Hits	271	Target Neighborhood Hits	742	Shared Neighborhood Hits	76
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

SRRM2_MOUSE
θ value	0.0193708 (rank : 31)	NC score	0.106329 (rank : 53)
Query Neighborhood Hits	271	Target Neighborhood Hits	1470	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

APBA1_HUMAN
θ value	0.0252991 (rank : 32)	NC score	0.116486 (rank : 35)
Query Neighborhood Hits	271	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

RGS3_HUMAN
θ value	0.0252991 (rank : 33)	NC score	0.107267 (rank : 49)
Query Neighborhood Hits	271	Target Neighborhood Hits	1375	Shared Neighborhood Hits	128
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SRRM1_MOUSE
θ value	0.0252991 (rank : 34)	NC score	0.126637 (rank : 28)
Query Neighborhood Hits	271	Target Neighborhood Hits	966	Shared Neighborhood Hits	90
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

CCNK_MOUSE
θ value	0.0330416 (rank : 35)	NC score	0.075655 (rank : 114)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

CD2AP_HUMAN
θ value	0.0330416 (rank : 36)	NC score	0.150565 (rank : 19)
Query Neighborhood Hits	271	Target Neighborhood Hits	315	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRRM1_HUMAN
θ value	0.0330416 (rank : 37)	NC score	0.108500 (rank : 47)
Query Neighborhood Hits	271	Target Neighborhood Hits	690	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WASL_HUMAN
θ value	0.0330416 (rank : 38)	NC score	0.108030 (rank : 48)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

IRX5_MOUSE
θ value	0.0431538 (rank : 39)	NC score	0.073902 (rank : 122)
Query Neighborhood Hits	271	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKQ4, Q80WV4, Q9JLL5	Gene names	Irx5, Irxb2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2).

MUC7_HUMAN
θ value	0.0563607 (rank : 40)	NC score	0.112032 (rank : 42)
Query Neighborhood Hits	271	Target Neighborhood Hits	538	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

OSTF1_HUMAN
θ value	0.0563607 (rank : 41)	NC score	0.126954 (rank : 27)
Query Neighborhood Hits	271	Target Neighborhood Hits	466	Shared Neighborhood Hits	65
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

CELR2_MOUSE
θ value	0.0736092 (rank : 42)	NC score	0.017421 (rank : 333)
Query Neighborhood Hits	271	Target Neighborhood Hits	584	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

PARM1_MOUSE
θ value	0.0736092 (rank : 43)	NC score	0.077487 (rank : 105)
Query Neighborhood Hits	271	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

DIAP1_MOUSE
θ value	0.0961366 (rank : 44)	NC score	0.060034 (rank : 186)
Query Neighborhood Hits	271	Target Neighborhood Hits	839	Shared Neighborhood Hits	32
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

MAGE1_HUMAN
θ value	0.0961366 (rank : 45)	NC score	0.093756 (rank : 70)
Query Neighborhood Hits	271	Target Neighborhood Hits	1389	Shared Neighborhood Hits	128
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SPEG_HUMAN
θ value	0.0961366 (rank : 46)	NC score	0.025041 (rank : 304)
Query Neighborhood Hits	271	Target Neighborhood Hits	1762	Shared Neighborhood Hits	83
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DOCK1_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.076081 (rank : 112)
Query Neighborhood Hits	271	Target Neighborhood Hits	191	Shared Neighborhood Hits	38
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

HNRL1_MOUSE
θ value	0.125558 (rank : 48)	NC score	0.088989 (rank : 83)
Query Neighborhood Hits	271	Target Neighborhood Hits	200	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

OSTF1_MOUSE
θ value	0.125558 (rank : 49)	NC score	0.119366 (rank : 31)
Query Neighborhood Hits	271	Target Neighborhood Hits	467	Shared Neighborhood Hits	65
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

HNRL1_HUMAN
θ value	0.163984 (rank : 50)	NC score	0.084793 (rank : 92)
Query Neighborhood Hits	271	Target Neighborhood Hits	173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

POGZ_MOUSE
θ value	0.163984 (rank : 51)	NC score	0.016075 (rank : 341)
Query Neighborhood Hits	271	Target Neighborhood Hits	765	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

PRP2_MOUSE
θ value	0.163984 (rank : 52)	NC score	0.088001 (rank : 86)
Query Neighborhood Hits	271	Target Neighborhood Hits	347	Shared Neighborhood Hits	32
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

WASL_MOUSE
θ value	0.163984 (rank : 53)	NC score	0.103524 (rank : 55)
Query Neighborhood Hits	271	Target Neighborhood Hits	339	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

FMNL_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.060092 (rank : 185)
Query Neighborhood Hits	271	Target Neighborhood Hits	529	Shared Neighborhood Hits	34
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

APBA3_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.092714 (rank : 73)
Query Neighborhood Hits	271	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

SPAST_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.016081 (rank : 340)
Query Neighborhood Hits	271	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

STAC_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.114619 (rank : 38)
Query Neighborhood Hits	271	Target Neighborhood Hits	268	Shared Neighborhood Hits	55
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

APBA2_HUMAN
θ value	0.365318 (rank : 58)	NC score	0.101578 (rank : 62)
Query Neighborhood Hits	271	Target Neighborhood Hits	220	Shared Neighborhood Hits	23
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
θ value	0.365318 (rank : 59)	NC score	0.100992 (rank : 63)
Query Neighborhood Hits	271	Target Neighborhood Hits	219	Shared Neighborhood Hits	20
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

ATBF1_MOUSE
θ value	0.365318 (rank : 60)	NC score	0.019581 (rank : 328)
Query Neighborhood Hits	271	Target Neighborhood Hits	1841	Shared Neighborhood Hits	63
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

DP13B_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.080274 (rank : 100)
Query Neighborhood Hits	271	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

IRX5_HUMAN
θ value	0.365318 (rank : 62)	NC score	0.051346 (rank : 244)
Query Neighborhood Hits	271	Target Neighborhood Hits	362	Shared Neighborhood Hits	25
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

NFH_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.061696 (rank : 176)
Query Neighborhood Hits	271	Target Neighborhood Hits	2247	Shared Neighborhood Hits	124
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RFX1_MOUSE
θ value	0.365318 (rank : 64)	NC score	0.040524 (rank : 267)
Query Neighborhood Hits	271	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

RIMB1_HUMAN
θ value	0.365318 (rank : 65)	NC score	0.063965 (rank : 159)
Query Neighborhood Hits	271	Target Neighborhood Hits	1479	Shared Neighborhood Hits	101
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SRBP1_HUMAN
θ value	0.365318 (rank : 66)	NC score	0.049842 (rank : 258)
Query Neighborhood Hits	271	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TARA_HUMAN
θ value	0.365318 (rank : 67)	NC score	0.072373 (rank : 125)
Query Neighborhood Hits	271	Target Neighborhood Hits	1626	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

APBA3_MOUSE
θ value	0.47712 (rank : 68)	NC score	0.095498 (rank : 69)
Query Neighborhood Hits	271	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

DP13A_HUMAN
θ value	0.47712 (rank : 69)	NC score	0.089347 (rank : 80)
Query Neighborhood Hits	271	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	0.47712 (rank : 70)	NC score	0.090066 (rank : 79)
Query Neighborhood Hits	271	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_MOUSE
θ value	0.47712 (rank : 71)	NC score	0.074746 (rank : 118)
Query Neighborhood Hits	271	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DREB_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.048610 (rank : 260)
Query Neighborhood Hits	271	Target Neighborhood Hits	450	Shared Neighborhood Hits	25
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ENAH_MOUSE
θ value	0.47712 (rank : 73)	NC score	0.059265 (rank : 193)
Query Neighborhood Hits	271	Target Neighborhood Hits	919	Shared Neighborhood Hits	55
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GNDS_MOUSE
θ value	0.47712 (rank : 74)	NC score	0.032553 (rank : 280)
Query Neighborhood Hits	271	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GSCR1_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.089075 (rank : 82)
Query Neighborhood Hits	271	Target Neighborhood Hits	674	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

NACAM_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.096148 (rank : 68)
Query Neighborhood Hits	271	Target Neighborhood Hits	1866	Shared Neighborhood Hits	138
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PTN4_HUMAN
θ value	0.47712 (rank : 77)	NC score	0.011399 (rank : 355)
Query Neighborhood Hits	271	Target Neighborhood Hits	303	Shared Neighborhood Hits	11
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

SH3G2_HUMAN
θ value	0.47712 (rank : 78)	NC score	0.116181 (rank : 36)
Query Neighborhood Hits	271	Target Neighborhood Hits	324	Shared Neighborhood Hits	54
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SHC1_HUMAN
θ value	0.47712 (rank : 79)	NC score	0.088262 (rank : 85)
Query Neighborhood Hits	271	Target Neighborhood Hits	170	Shared Neighborhood Hits	32
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	0.47712 (rank : 80)	NC score	0.090649 (rank : 78)
Query Neighborhood Hits	271	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

WASF3_HUMAN
θ value	0.47712 (rank : 81)	NC score	0.051551 (rank : 241)
Query Neighborhood Hits	271	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

ARHGG_MOUSE
θ value	0.62314 (rank : 82)	NC score	0.088680 (rank : 84)
Query Neighborhood Hits	271	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

CRK_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.093068 (rank : 72)
Query Neighborhood Hits	271	Target Neighborhood Hits	308	Shared Neighborhood Hits	60
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	0.62314 (rank : 84)	NC score	0.093737 (rank : 71)
Query Neighborhood Hits	271	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

FBLI1_MOUSE
θ value	0.62314 (rank : 85)	NC score	0.023249 (rank : 311)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

HCN4_MOUSE
θ value	0.62314 (rank : 86)	NC score	0.028983 (rank : 290)
Query Neighborhood Hits	271	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

LASP1_HUMAN
θ value	0.62314 (rank : 87)	NC score	0.139351 (rank : 23)
Query Neighborhood Hits	271	Target Neighborhood Hits	293	Shared Neighborhood Hits	58
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.62314 (rank : 88)	NC score	0.139795 (rank : 22)
Query Neighborhood Hits	271	Target Neighborhood Hits	297	Shared Neighborhood Hits	58
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

RERE_MOUSE
θ value	0.62314 (rank : 89)	NC score	0.064105 (rank : 158)
Query Neighborhood Hits	271	Target Neighborhood Hits	785	Shared Neighborhood Hits	58
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SH3G3_MOUSE
θ value	0.62314 (rank : 90)	NC score	0.116988 (rank : 33)
Query Neighborhood Hits	271	Target Neighborhood Hits	236	Shared Neighborhood Hits	54
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

CT175_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.063248 (rank : 163)
Query Neighborhood Hits	271	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MK2, Q5QPB6, Q9NQQ2	Gene names	C20orf175
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf175.

DAB1_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.101648 (rank : 61)
Query Neighborhood Hits	271	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DAB1_MOUSE
θ value	0.813845 (rank : 93)	NC score	0.100355 (rank : 66)
Query Neighborhood Hits	271	Target Neighborhood Hits	145	Shared Neighborhood Hits	31
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

DNMBP_HUMAN
θ value	0.813845 (rank : 94)	NC score	0.112413 (rank : 41)
Query Neighborhood Hits	271	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ELOA2_HUMAN
θ value	0.813845 (rank : 95)	NC score	0.051189 (rank : 246)
Query Neighborhood Hits	271	Target Neighborhood Hits	165	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

NEBL_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.116868 (rank : 34)
Query Neighborhood Hits	271	Target Neighborhood Hits	457	Shared Neighborhood Hits	59
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

P85A_MOUSE
θ value	0.813845 (rank : 97)	NC score	0.065573 (rank : 152)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	49
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PRR12_HUMAN
θ value	0.813845 (rank : 98)	NC score	0.068462 (rank : 143)
Query Neighborhood Hits	271	Target Neighborhood Hits	460	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SF3B4_HUMAN
θ value	0.813845 (rank : 99)	NC score	0.021389 (rank : 321)
Query Neighborhood Hits	271	Target Neighborhood Hits	445	Shared Neighborhood Hits	26
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

SON_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.079720 (rank : 101)
Query Neighborhood Hits	271	Target Neighborhood Hits	957	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SYN2_HUMAN
θ value	0.813845 (rank : 101)	NC score	0.061512 (rank : 180)
Query Neighborhood Hits	271	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	Q92777	Gene names	SYN2
Domain Architecture
Description	Synapsin-2 (Synapsin II).

YLPM1_HUMAN
θ value	0.813845 (rank : 102)	NC score	0.087111 (rank : 88)
Query Neighborhood Hits	271	Target Neighborhood Hits	670	Shared Neighborhood Hits	71
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ACINU_MOUSE
θ value	1.06291 (rank : 103)	NC score	0.037855 (rank : 274)
Query Neighborhood Hits	271	Target Neighborhood Hits	712	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACK1_HUMAN
θ value	1.06291 (rank : 104)	NC score	0.026559 (rank : 296)
Query Neighborhood Hits	271	Target Neighborhood Hits	1140	Shared Neighborhood Hits	78
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.024900 (rank : 306)
Query Neighborhood Hits	271	Target Neighborhood Hits	1080	Shared Neighborhood Hits	72
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ARHGF_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.063587 (rank : 160)
Query Neighborhood Hits	271	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ATN1_HUMAN
θ value	1.06291 (rank : 107)	NC score	0.068111 (rank : 145)
Query Neighborhood Hits	271	Target Neighborhood Hits	676	Shared Neighborhood Hits	55
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BCL6B_HUMAN
θ value	1.06291 (rank : 108)	NC score	0.003460 (rank : 377)
Query Neighborhood Hits	271	Target Neighborhood Hits	855	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N143, Q6PCB4	Gene names	BCL6B, BAZF, ZNF62
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 6 member B protein (Bcl6-associated zinc finger protein) (Zinc finger protein 62).

CAC1B_HUMAN
θ value	1.06291 (rank : 109)	NC score	0.022359 (rank : 315)
Query Neighborhood Hits	271	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

COIA1_MOUSE
θ value	1.06291 (rank : 110)	NC score	0.029377 (rank : 287)
Query Neighborhood Hits	271	Target Neighborhood Hits	481	Shared Neighborhood Hits	34
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

DIAP1_HUMAN
θ value	1.06291 (rank : 111)	NC score	0.059800 (rank : 188)
Query Neighborhood Hits	271	Target Neighborhood Hits	784	Shared Neighborhood Hits	44
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

EFS_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.097295 (rank : 67)
Query Neighborhood Hits	271	Target Neighborhood Hits	348	Shared Neighborhood Hits	76
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

FMN1A_MOUSE
θ value	1.06291 (rank : 113)	NC score	0.076662 (rank : 108)
Query Neighborhood Hits	271	Target Neighborhood Hits	423	Shared Neighborhood Hits	45
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	1.06291 (rank : 114)	NC score	0.073182 (rank : 124)
Query Neighborhood Hits	271	Target Neighborhood Hits	447	Shared Neighborhood Hits	40
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

FUT8_HUMAN
θ value	1.06291 (rank : 115)	NC score	0.106832 (rank : 50)
Query Neighborhood Hits	271	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	1.06291 (rank : 116)	NC score	0.100598 (rank : 65)
Query Neighborhood Hits	271	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FYN_HUMAN
θ value	1.06291 (rank : 117)	NC score	0.025740 (rank : 300)
Query Neighborhood Hits	271	Target Neighborhood Hits	1078	Shared Neighborhood Hits	70
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	1.06291 (rank : 118)	NC score	0.026064 (rank : 298)
Query Neighborhood Hits	271	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LAP2_HUMAN
θ value	1.06291 (rank : 119)	NC score	0.009300 (rank : 366)
Query Neighborhood Hits	271	Target Neighborhood Hits	499	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

MAST3_HUMAN
θ value	1.06291 (rank : 120)	NC score	0.011676 (rank : 354)
Query Neighborhood Hits	271	Target Neighborhood Hits	1128	Shared Neighborhood Hits	47
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

NCF2_HUMAN
θ value	1.06291 (rank : 121)	NC score	0.136618 (rank : 24)
Query Neighborhood Hits	271	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

RFX1_HUMAN
θ value	1.06291 (rank : 122)	NC score	0.049958 (rank : 257)
Query Neighborhood Hits	271	Target Neighborhood Hits	256	Shared Neighborhood Hits	37
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SC24C_HUMAN
θ value	1.06291 (rank : 123)	NC score	0.082695 (rank : 97)
Query Neighborhood Hits	271	Target Neighborhood Hits	662	Shared Neighborhood Hits	86
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SH3G1_HUMAN
θ value	1.06291 (rank : 124)	NC score	0.111883 (rank : 44)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SHC2_MOUSE
θ value	1.06291 (rank : 125)	NC score	0.084066 (rank : 94)
Query Neighborhood Hits	271	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SOX18_HUMAN
θ value	1.06291 (rank : 126)	NC score	0.029634 (rank : 285)
Query Neighborhood Hits	271	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

STAC_HUMAN
θ value	1.06291 (rank : 127)	NC score	0.102274 (rank : 59)
Query Neighborhood Hits	271	Target Neighborhood Hits	276	Shared Neighborhood Hits	57
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SYTL5_HUMAN
θ value	1.06291 (rank : 128)	NC score	0.017366 (rank : 334)
Query Neighborhood Hits	271	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

TAF4_HUMAN
θ value	1.06291 (rank : 129)	NC score	0.087625 (rank : 87)
Query Neighborhood Hits	271	Target Neighborhood Hits	687	Shared Neighborhood Hits	56
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

WASIP_HUMAN
θ value	1.06291 (rank : 130)	NC score	0.103094 (rank : 56)
Query Neighborhood Hits	271	Target Neighborhood Hits	458	Shared Neighborhood Hits	45
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

ZN516_MOUSE
θ value	1.06291 (rank : 131)	NC score	0.018457 (rank : 332)
Query Neighborhood Hits	271	Target Neighborhood Hits	1197	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

3BP2_HUMAN
θ value	1.38821 (rank : 132)	NC score	0.059661 (rank : 189)
Query Neighborhood Hits	271	Target Neighborhood Hits	296	Shared Neighborhood Hits	48
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

APBB1_HUMAN
θ value	1.38821 (rank : 133)	NC score	0.082534 (rank : 98)
Query Neighborhood Hits	271	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	1.38821 (rank : 134)	NC score	0.081784 (rank : 99)
Query Neighborhood Hits	271	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

ARHG7_HUMAN
θ value	1.38821 (rank : 135)	NC score	0.085050 (rank : 91)
Query Neighborhood Hits	271	Target Neighborhood Hits	347	Shared Neighborhood Hits	58
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

GGN_HUMAN
θ value	1.38821 (rank : 136)	NC score	0.066216 (rank : 151)
Query Neighborhood Hits	271	Target Neighborhood Hits	269	Shared Neighborhood Hits	34
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MLL4_HUMAN
θ value	1.38821 (rank : 137)	NC score	0.051296 (rank : 245)
Query Neighborhood Hits	271	Target Neighborhood Hits	722	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

SH3G2_MOUSE
θ value	1.38821 (rank : 138)	NC score	0.111839 (rank : 45)
Query Neighborhood Hits	271	Target Neighborhood Hits	319	Shared Neighborhood Hits	55
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	1.38821 (rank : 139)	NC score	0.113878 (rank : 39)
Query Neighborhood Hits	271	Target Neighborhood Hits	222	Shared Neighborhood Hits	52
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

WIRE_MOUSE
θ value	1.38821 (rank : 140)	NC score	0.085420 (rank : 89)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

YLPM1_MOUSE
θ value	1.38821 (rank : 141)	NC score	0.065242 (rank : 154)
Query Neighborhood Hits	271	Target Neighborhood Hits	505	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

BRSK1_HUMAN
θ value	1.81305 (rank : 142)	NC score	0.007406 (rank : 370)
Query Neighborhood Hits	271	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CRSP2_HUMAN
θ value	1.81305 (rank : 143)	NC score	0.069996 (rank : 136)
Query Neighborhood Hits	271	Target Neighborhood Hits	380	Shared Neighborhood Hits	51
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CSKI2_HUMAN
θ value	1.81305 (rank : 144)	NC score	0.042026 (rank : 265)
Query Neighborhood Hits	271	Target Neighborhood Hits	747	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GBX1_HUMAN
θ value	1.81305 (rank : 145)	NC score	0.008571 (rank : 367)
Query Neighborhood Hits	271	Target Neighborhood Hits	334	Shared Neighborhood Hits	9
SwissProt Accessions	Q14549	Gene names	GBX1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

HCN4_HUMAN
θ value	1.81305 (rank : 146)	NC score	0.028907 (rank : 291)
Query Neighborhood Hits	271	Target Neighborhood Hits	303	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

RAPH1_HUMAN
θ value	1.81305 (rank : 147)	NC score	0.069258 (rank : 139)
Query Neighborhood Hits	271	Target Neighborhood Hits	593	Shared Neighborhood Hits	70
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SH3G1_MOUSE
θ value	1.81305 (rank : 148)	NC score	0.109494 (rank : 46)
Query Neighborhood Hits	271	Target Neighborhood Hits	291	Shared Neighborhood Hits	53
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3K1_HUMAN
θ value	1.81305 (rank : 149)	NC score	0.117650 (rank : 32)
Query Neighborhood Hits	271	Target Neighborhood Hits	341	Shared Neighborhood Hits	71
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SIGL5_MOUSE
θ value	1.81305 (rank : 150)	NC score	0.010829 (rank : 359)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

STS1_HUMAN
θ value	1.81305 (rank : 151)	NC score	0.106388 (rank : 52)
Query Neighborhood Hits	271	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ZN687_MOUSE
θ value	1.81305 (rank : 152)	NC score	0.012550 (rank : 350)
Query Neighborhood Hits	271	Target Neighborhood Hits	913	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ANKS6_MOUSE
θ value	2.36792 (rank : 153)	NC score	0.022511 (rank : 314)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

AP2A1_MOUSE
θ value	2.36792 (rank : 154)	NC score	0.019174 (rank : 329)
Query Neighborhood Hits	271	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

CT075_HUMAN
θ value	2.36792 (rank : 155)	NC score	0.015637 (rank : 343)
Query Neighborhood Hits	271	Target Neighborhood Hits	387	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

FILA_HUMAN
θ value	2.36792 (rank : 156)	NC score	0.023266 (rank : 310)
Query Neighborhood Hits	271	Target Neighborhood Hits	685	Shared Neighborhood Hits	27
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

GTF2I_HUMAN
θ value	2.36792 (rank : 157)	NC score	0.022058 (rank : 317)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	15
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

P85A_HUMAN
θ value	2.36792 (rank : 158)	NC score	0.056036 (rank : 210)
Query Neighborhood Hits	271	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PELP1_HUMAN
θ value	2.36792 (rank : 159)	NC score	0.049360 (rank : 259)
Query Neighborhood Hits	271	Target Neighborhood Hits	596	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

SHC2_HUMAN
θ value	2.36792 (rank : 160)	NC score	0.076103 (rank : 111)
Query Neighborhood Hits	271	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

TENS1_HUMAN
θ value	2.36792 (rank : 161)	NC score	0.044342 (rank : 264)
Query Neighborhood Hits	271	Target Neighborhood Hits	400	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TXK_MOUSE
θ value	2.36792 (rank : 162)	NC score	0.020150 (rank : 324)
Query Neighborhood Hits	271	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WBS14_HUMAN
θ value	2.36792 (rank : 163)	NC score	0.035924 (rank : 277)
Query Neighborhood Hits	271	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

AMOL1_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.012291 (rank : 351)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

AP2A1_HUMAN
θ value	3.0926 (rank : 165)	NC score	0.019966 (rank : 326)
Query Neighborhood Hits	271	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

ARHG7_MOUSE
θ value	3.0926 (rank : 166)	NC score	0.085225 (rank : 90)
Query Neighborhood Hits	271	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CABL2_HUMAN
θ value	3.0926 (rank : 167)	NC score	0.026248 (rank : 297)
Query Neighborhood Hits	271	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

DMP1_MOUSE
θ value	3.0926 (rank : 168)	NC score	0.026916 (rank : 294)
Query Neighborhood Hits	271	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

GAK_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.016948 (rank : 335)
Query Neighborhood Hits	271	Target Neighborhood Hits	1028	Shared Neighborhood Hits	51
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GBX1_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.010871 (rank : 358)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	10
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

IRX2_HUMAN
θ value	3.0926 (rank : 171)	NC score	0.031876 (rank : 281)
Query Neighborhood Hits	271	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BZI1, Q7Z2I7	Gene names	IRX2, IRXA2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-2 (Iroquois homeobox protein 2) (Homeodomain protein IRXA2).

NPAS1_MOUSE
θ value	3.0926 (rank : 172)	NC score	0.009932 (rank : 364)
Query Neighborhood Hits	271	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

RTN4_HUMAN
θ value	3.0926 (rank : 173)	NC score	0.045294 (rank : 263)
Query Neighborhood Hits	271	Target Neighborhood Hits	357	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SMRC2_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.025891 (rank : 299)
Query Neighborhood Hits	271	Target Neighborhood Hits	499	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SPEG_MOUSE
θ value	3.0926 (rank : 175)	NC score	0.025637 (rank : 302)
Query Neighborhood Hits	271	Target Neighborhood Hits	1959	Shared Neighborhood Hits	120
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STS1_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.102496 (rank : 57)
Query Neighborhood Hits	271	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

WASF2_MOUSE
θ value	3.0926 (rank : 177)	NC score	0.063394 (rank : 162)
Query Neighborhood Hits	271	Target Neighborhood Hits	315	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WASF4_HUMAN
θ value	3.0926 (rank : 178)	NC score	0.060354 (rank : 183)
Query Neighborhood Hits	271	Target Neighborhood Hits	282	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

ANK2_HUMAN
θ value	4.03905 (rank : 179)	NC score	0.040171 (rank : 268)
Query Neighborhood Hits	271	Target Neighborhood Hits	1615	Shared Neighborhood Hits	102
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

COFA1_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.029815 (rank : 284)
Query Neighborhood Hits	271	Target Neighborhood Hits	305	Shared Neighborhood Hits	26
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

COIA1_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.039274 (rank : 270)
Query Neighborhood Hits	271	Target Neighborhood Hits	447	Shared Neighborhood Hits	35
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

DMRTC_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.022581 (rank : 313)
Query Neighborhood Hits	271	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

ERF_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.021218 (rank : 322)
Query Neighborhood Hits	271	Target Neighborhood Hits	162	Shared Neighborhood Hits	16
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

KLF16_HUMAN
θ value	4.03905 (rank : 184)	NC score	0.000485 (rank : 380)
Query Neighborhood Hits	271	Target Neighborhood Hits	737	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BXK1	Gene names	KLF16, BTEB4, NSLP2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor NSLP2).

LDB3_HUMAN
θ value	4.03905 (rank : 185)	NC score	0.021792 (rank : 319)
Query Neighborhood Hits	271	Target Neighborhood Hits	497	Shared Neighborhood Hits	34
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

MELPH_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.028907 (rank : 292)
Query Neighborhood Hits	271	Target Neighborhood Hits	145	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

NFAC4_HUMAN
θ value	4.03905 (rank : 187)	NC score	0.029041 (rank : 288)
Query Neighborhood Hits	271	Target Neighborhood Hits	165	Shared Neighborhood Hits	18
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

SFPQ_MOUSE
θ value	4.03905 (rank : 188)	NC score	0.036994 (rank : 275)
Query Neighborhood Hits	271	Target Neighborhood Hits	958	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

TBCD1_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.019748 (rank : 327)
Query Neighborhood Hits	271	Target Neighborhood Hits	241	Shared Neighborhood Hits	14
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

TCAL5_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.021090 (rank : 323)
Query Neighborhood Hits	271	Target Neighborhood Hits	806	Shared Neighborhood Hits	33
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TIMD2_MOUSE
θ value	4.03905 (rank : 191)	NC score	0.029032 (rank : 289)
Query Neighborhood Hits	271	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

TMAP1_HUMAN
θ value	4.03905 (rank : 192)	NC score	0.052074 (rank : 235)
Query Neighborhood Hits	271	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

WIRE_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.083872 (rank : 95)
Query Neighborhood Hits	271	Target Neighborhood Hits	329	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

XRCC1_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.036728 (rank : 276)
Query Neighborhood Hits	271	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

CAC1B_MOUSE
θ value	5.27518 (rank : 195)	NC score	0.024929 (rank : 305)
Query Neighborhood Hits	271	Target Neighborhood Hits	351	Shared Neighborhood Hits	39
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CI079_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.054043 (rank : 222)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

E2F1_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.010691 (rank : 360)
Query Neighborhood Hits	271	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

EFS_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.091700 (rank : 77)
Query Neighborhood Hits	271	Target Neighborhood Hits	389	Shared Neighborhood Hits	92
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FOXJ2_MOUSE
θ value	5.27518 (rank : 199)	NC score	0.012029 (rank : 352)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ES18	Gene names	Foxj2, Fhx
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

LCK_HUMAN
θ value	5.27518 (rank : 200)	NC score	0.016935 (rank : 336)
Query Neighborhood Hits	271	Target Neighborhood Hits	987	Shared Neighborhood Hits	57
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	5.27518 (rank : 201)	NC score	0.016836 (rank : 337)
Query Neighborhood Hits	271	Target Neighborhood Hits	981	Shared Neighborhood Hits	57
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MBD6_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.076817 (rank : 106)
Query Neighborhood Hits	271	Target Neighborhood Hits	349	Shared Neighborhood Hits	39
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MICA1_MOUSE
θ value	5.27518 (rank : 203)	NC score	0.008486 (rank : 368)
Query Neighborhood Hits	271	Target Neighborhood Hits	400	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MINK1_MOUSE
θ value	5.27518 (rank : 204)	NC score	0.005645 (rank : 376)
Query Neighborhood Hits	271	Target Neighborhood Hits	1451	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYO1F_MOUSE
θ value	5.27518 (rank : 205)	NC score	0.038999 (rank : 271)
Query Neighborhood Hits	271	Target Neighborhood Hits	262	Shared Neighborhood Hits	53
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCK1_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.074340 (rank : 120)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	61
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

RIMB1_MOUSE
θ value	5.27518 (rank : 207)	NC score	0.046067 (rank : 262)
Query Neighborhood Hits	271	Target Neighborhood Hits	1376	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SH3K1_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.120894 (rank : 29)
Query Neighborhood Hits	271	Target Neighborhood Hits	332	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SOS2_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.024381 (rank : 307)
Query Neighborhood Hits	271	Target Neighborhood Hits	193	Shared Neighborhood Hits	19
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SYGP1_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.010443 (rank : 361)
Query Neighborhood Hits	271	Target Neighborhood Hits	589	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

ABI2_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.089110 (rank : 81)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	6.88961 (rank : 212)	NC score	0.083801 (rank : 96)
Query Neighborhood Hits	271	Target Neighborhood Hits	266	Shared Neighborhood Hits	63
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ARI1A_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.052774 (rank : 232)
Query Neighborhood Hits	271	Target Neighborhood Hits	787	Shared Neighborhood Hits	82
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

AUXI_HUMAN
θ value	6.88961 (rank : 214)	NC score	0.022923 (rank : 312)
Query Neighborhood Hits	271	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

CEND3_HUMAN
θ value	6.88961 (rank : 215)	NC score	0.011830 (rank : 353)
Query Neighborhood Hits	271	Target Neighborhood Hits	275	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CO9A3_HUMAN
θ value	6.88961 (rank : 216)	NC score	0.015042 (rank : 344)
Query Neighborhood Hits	271	Target Neighborhood Hits	361	Shared Neighborhood Hits	26
SwissProt Accessions	Q14050, Q13681, Q9H4G9, Q9UPE2	Gene names	COL9A3
Domain Architecture	No domain graphic available
Description	Collagen alpha-3(IX) chain precursor.

DNMBP_MOUSE
θ value	6.88961 (rank : 217)	NC score	0.102456 (rank : 58)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GNDS_HUMAN
θ value	6.88961 (rank : 218)	NC score	0.031698 (rank : 282)
Query Neighborhood Hits	271	Target Neighborhood Hits	201	Shared Neighborhood Hits	18
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

HNRPK_HUMAN
θ value	6.88961 (rank : 219)	NC score	0.016721 (rank : 338)
Query Neighborhood Hits	271	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.016721 (rank : 339)
Query Neighborhood Hits	271	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

IER2_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.025451 (rank : 303)
Query Neighborhood Hits	271	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P17950, Q64251, Q8BME8, Q99M25	Gene names	Ier2
Domain Architecture
Description	Immediate early response gene 2 protein (T-lymphocyte-activated protein) (Cycloheximide-induced gene protein) (CHX1) (Growth factor- inducible immediate early protein) (Proline-rich-induced protein 92) (Pip92).

INP4A_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.009594 (rank : 365)
Query Neighborhood Hits	271	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PE3, O15326, Q13187, Q53TD8, Q8TC02	Gene names	INPP4A
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

JIP3_HUMAN
θ value	6.88961 (rank : 223)	NC score	0.034000 (rank : 279)
Query Neighborhood Hits	271	Target Neighborhood Hits	1039	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

KBTBB_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.007100 (rank : 372)
Query Neighborhood Hits	271	Target Neighborhood Hits	195	Shared Neighborhood Hits	7
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

MAML3_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.046426 (rank : 261)
Query Neighborhood Hits	271	Target Neighborhood Hits	323	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MYO1F_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.038974 (rank : 272)
Query Neighborhood Hits	271	Target Neighborhood Hits	275	Shared Neighborhood Hits	60
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYST4_HUMAN
θ value	6.88961 (rank : 227)	NC score	0.011230 (rank : 356)
Query Neighborhood Hits	271	Target Neighborhood Hits	671	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

NGEF_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.076322 (rank : 109)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

OAZ1_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.021972 (rank : 318)
Query Neighborhood Hits	271	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P54368, O43382, Q14989, Q92595, Q9UPL9	Gene names	OAZ1, OAZ
Domain Architecture
Description	Ornithine decarboxylase antizyme (ODC-Az).

SHC3_MOUSE
θ value	6.88961 (rank : 230)	NC score	0.059063 (rank : 195)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

T22D4_MOUSE
θ value	6.88961 (rank : 231)	NC score	0.030596 (rank : 283)
Query Neighborhood Hits	271	Target Neighborhood Hits	92	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

TXND2_MOUSE
θ value	6.88961 (rank : 232)	NC score	0.018973 (rank : 330)
Query Neighborhood Hits	271	Target Neighborhood Hits	828	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

ULK1_MOUSE
θ value	6.88961 (rank : 233)	NC score	0.012981 (rank : 348)
Query Neighborhood Hits	271	Target Neighborhood Hits	1214	Shared Neighborhood Hits	88
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

WASIP_MOUSE
θ value	6.88961 (rank : 234)	NC score	0.075993 (rank : 113)
Query Neighborhood Hits	271	Target Neighborhood Hits	392	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

ZBT16_HUMAN
θ value	6.88961 (rank : 235)	NC score	-0.001336 (rank : 381)
Query Neighborhood Hits	271	Target Neighborhood Hits	1010	Shared Neighborhood Hits	40
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

AFF1_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.039963 (rank : 269)
Query Neighborhood Hits	271	Target Neighborhood Hits	506	Shared Neighborhood Hits	43
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

BAT2_HUMAN
θ value	8.99809 (rank : 237)	NC score	0.062611 (rank : 167)
Query Neighborhood Hits	271	Target Neighborhood Hits	931	Shared Neighborhood Hits	87
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT2_MOUSE
θ value	8.99809 (rank : 238)	NC score	0.062516 (rank : 168)
Query Neighborhood Hits	271	Target Neighborhood Hits	947	Shared Neighborhood Hits	96
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CAC1H_MOUSE
θ value	8.99809 (rank : 239)	NC score	0.010890 (rank : 357)
Query Neighborhood Hits	271	Target Neighborhood Hits	230	Shared Neighborhood Hits	23
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CBX6_MOUSE
θ value	8.99809 (rank : 240)	NC score	0.007504 (rank : 369)
Query Neighborhood Hits	271	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

CN155_HUMAN
θ value	8.99809 (rank : 241)	NC score	0.055450 (rank : 214)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CSKI1_HUMAN
θ value	8.99809 (rank : 242)	NC score	0.041373 (rank : 266)
Query Neighborhood Hits	271	Target Neighborhood Hits	997	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DDX31_HUMAN
θ value	8.99809 (rank : 243)	NC score	0.002843 (rank : 378)
Query Neighborhood Hits	271	Target Neighborhood Hits	132	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DGKK_HUMAN
θ value	8.99809 (rank : 244)	NC score	0.023827 (rank : 309)
Query Neighborhood Hits	271	Target Neighborhood Hits	378	Shared Neighborhood Hits	29
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EI2BE_HUMAN
θ value	8.99809 (rank : 245)	NC score	0.015649 (rank : 342)
Query Neighborhood Hits	271	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q13144, Q96D04	Gene names	EIF2B5, EIF2BE
Domain Architecture
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

ESPL1_HUMAN
θ value	8.99809 (rank : 246)	NC score	0.012780 (rank : 349)
Query Neighborhood Hits	271	Target Neighborhood Hits	95	Shared Neighborhood Hits	11
SwissProt Accessions	Q14674	Gene names	ESPL1, ESP1, KIAA0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

FGR_HUMAN
θ value	8.99809 (rank : 247)	NC score	0.022251 (rank : 316)
Query Neighborhood Hits	271	Target Neighborhood Hits	1067	Shared Neighborhood Hits	67
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FKBP4_HUMAN
θ value	8.99809 (rank : 248)	NC score	0.007387 (rank : 371)
Query Neighborhood Hits	271	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q02790, Q9UCP1, Q9UCV7	Gene names	FKBP4
Domain Architecture
Description	FK506-binding protein 4 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP-binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein) (FKBP59).

FOG1_HUMAN
θ value	8.99809 (rank : 249)	NC score	0.006215 (rank : 375)
Query Neighborhood Hits	271	Target Neighborhood Hits	981	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

FOXJ2_HUMAN
θ value	8.99809 (rank : 250)	NC score	0.010130 (rank : 363)
Query Neighborhood Hits	271	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

GLT11_HUMAN
θ value	8.99809 (rank : 251)	NC score	0.002044 (rank : 379)
Query Neighborhood Hits	271	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCW6, Q6PCD1, Q9H6C2, Q9H6Z5, Q9UDR8	Gene names	GALNT11
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11).

HXA3_MOUSE
θ value	8.99809 (rank : 252)	NC score	0.013431 (rank : 347)
Query Neighborhood Hits	271	Target Neighborhood Hits	558	Shared Neighborhood Hits	37
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

JPH2_MOUSE
θ value	8.99809 (rank : 253)	NC score	0.023881 (rank : 308)
Query Neighborhood Hits	271	Target Neighborhood Hits	279	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MINT_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.028756 (rank : 293)
Query Neighborhood Hits	271	Target Neighborhood Hits	1291	Shared Neighborhood Hits	70
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MLL3_HUMAN
θ value	8.99809 (rank : 255)	NC score	0.064663 (rank : 157)
Query Neighborhood Hits	271	Target Neighborhood Hits	1644	Shared Neighborhood Hits	120
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MNT_MOUSE
θ value	8.99809 (rank : 256)	NC score	0.038500 (rank : 273)
Query Neighborhood Hits	271	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCK2_HUMAN
θ value	8.99809 (rank : 257)	NC score	0.074943 (rank : 116)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NOL3_MOUSE
θ value	8.99809 (rank : 258)	NC score	0.025727 (rank : 301)
Query Neighborhood Hits	271	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D1X0	Gene names	Nol3
Domain Architecture
Description	Nucleolar protein 3.

PDCD7_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.021448 (rank : 320)
Query Neighborhood Hits	271	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

PGCA_HUMAN
θ value	8.99809 (rank : 260)	NC score	0.020038 (rank : 325)
Query Neighborhood Hits	271	Target Neighborhood Hits	821	Shared Neighborhood Hits	38
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PO2F2_HUMAN
θ value	8.99809 (rank : 261)	NC score	0.006264 (rank : 374)
Query Neighborhood Hits	271	Target Neighborhood Hits	379	Shared Neighborhood Hits	21
SwissProt Accessions	P09086, Q16648, Q9BRS4	Gene names	POU2F2, OCT2, OTF2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

PRB4S_HUMAN
θ value	8.99809 (rank : 262)	NC score	0.062944 (rank : 165)
Query Neighborhood Hits	271	Target Neighborhood Hits	330	Shared Neighborhood Hits	34
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PSD4_MOUSE
θ value	8.99809 (rank : 263)	NC score	0.006699 (rank : 373)
Query Neighborhood Hits	271	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

RAI1_MOUSE
θ value	8.99809 (rank : 264)	NC score	0.029402 (rank : 286)
Query Neighborhood Hits	271	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

RECQ4_HUMAN
θ value	8.99809 (rank : 265)	NC score	0.010229 (rank : 362)
Query Neighborhood Hits	271	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RNF25_HUMAN
θ value	8.99809 (rank : 266)	NC score	0.026751 (rank : 295)
Query Neighborhood Hits	271	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

SEN34_MOUSE
θ value	8.99809 (rank : 267)	NC score	0.014752 (rank : 345)
Query Neighborhood Hits	271	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

SYN1_MOUSE
θ value	8.99809 (rank : 268)	NC score	0.077966 (rank : 103)
Query Neighborhood Hits	271	Target Neighborhood Hits	363	Shared Neighborhood Hits	41
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

TENS4_MOUSE
θ value	8.99809 (rank : 269)	NC score	0.034097 (rank : 278)
Query Neighborhood Hits	271	Target Neighborhood Hits	225	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TXK_HUMAN
θ value	8.99809 (rank : 270)	NC score	0.014216 (rank : 346)
Query Neighborhood Hits	271	Target Neighborhood Hits	971	Shared Neighborhood Hits	49
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

WASF2_HUMAN
θ value	8.99809 (rank : 271)	NC score	0.053153 (rank : 228)
Query Neighborhood Hits	271	Target Neighborhood Hits	280	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

ABI1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.070467 (rank : 134)
Query Neighborhood Hits	271	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.071066 (rank : 132)
Query Neighborhood Hits	271	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.077596 (rank : 104)
Query Neighborhood Hits	271	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.070635 (rank : 133)
Query Neighborhood Hits	271	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

APBB3_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.050439 (rank : 253)
Query Neighborhood Hits	271	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.050375 (rank : 254)
Query Neighborhood Hits	271	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

ARHG6_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.074287 (rank : 121)
Query Neighborhood Hits	271	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.068362 (rank : 144)
Query Neighborhood Hits	271	Target Neighborhood Hits	394	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ASPP1_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.059463 (rank : 191)
Query Neighborhood Hits	271	Target Neighborhood Hits	1244	Shared Neighborhood Hits	124
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.076778 (rank : 107)
Query Neighborhood Hits	271	Target Neighborhood Hits	554	Shared Neighborhood Hits	109
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.065491 (rank : 153)
Query Neighborhood Hits	271	Target Neighborhood Hits	438	Shared Neighborhood Hits	94
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCL9_HUMAN
θ value	θ > 10 (rank : 283)	NC score	0.069299 (rank : 138)
Query Neighborhood Hits	271	Target Neighborhood Hits	1008	Shared Neighborhood Hits	106
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BCL9_MOUSE
θ value	θ > 10 (rank : 284)	NC score	0.050089 (rank : 256)
Query Neighborhood Hits	271	Target Neighborhood Hits	770	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BIN1_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.051141 (rank : 247)
Query Neighborhood Hits	271	Target Neighborhood Hits	335	Shared Neighborhood Hits	64
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BSN_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.057226 (rank : 207)
Query Neighborhood Hits	271	Target Neighborhood Hits	1537	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BSN_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.076318 (rank : 110)
Query Neighborhood Hits	271	Target Neighborhood Hits	2057	Shared Neighborhood Hits	142
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CBP_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.051648 (rank : 239)
Query Neighborhood Hits	271	Target Neighborhood Hits	1051	Shared Neighborhood Hits	100
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CD2AP_MOUSE
θ value	θ > 10 (rank : 289)	NC score	0.100768 (rank : 64)
Query Neighborhood Hits	271	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CD2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051378 (rank : 243)
Query Neighborhood Hits	271	Target Neighborhood Hits	504	Shared Neighborhood Hits	70
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CEL_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.059945 (rank : 187)
Query Neighborhood Hits	271	Target Neighborhood Hits	896	Shared Neighborhood Hits	93
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CK024_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.055037 (rank : 215)
Query Neighborhood Hits	271	Target Neighborhood Hits	408	Shared Neighborhood Hits	64
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CO039_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.057445 (rank : 205)
Query Neighborhood Hits	271	Target Neighborhood Hits	445	Shared Neighborhood Hits	74
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CRKL_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.070189 (rank : 135)
Query Neighborhood Hits	271	Target Neighborhood Hits	313	Shared Neighborhood Hits	58
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.068958 (rank : 140)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CT032_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.056032 (rank : 211)
Query Neighborhood Hits	271	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DAB2_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.066815 (rank : 149)
Query Neighborhood Hits	271	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

DAB2_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.064885 (rank : 155)
Query Neighborhood Hits	271	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

DBNL_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.058476 (rank : 198)
Query Neighborhood Hits	271	Target Neighborhood Hits	244	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.059421 (rank : 192)
Query Neighborhood Hits	271	Target Neighborhood Hits	306	Shared Neighborhood Hits	48
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.063085 (rank : 164)
Query Neighborhood Hits	271	Target Neighborhood Hits	599	Shared Neighborhood Hits	68
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.061944 (rank : 173)
Query Neighborhood Hits	271	Target Neighborhood Hits	625	Shared Neighborhood Hits	65
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

FA47A_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.057049 (rank : 208)
Query Neighborhood Hits	271	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FA47B_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.061070 (rank : 182)
Query Neighborhood Hits	271	Target Neighborhood Hits	431	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FMN2_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.051555 (rank : 240)
Query Neighborhood Hits	271	Target Neighborhood Hits	484	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FMN2_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.059550 (rank : 190)
Query Neighborhood Hits	271	Target Neighborhood Hits	349	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

GRAP2_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.060212 (rank : 184)
Query Neighborhood Hits	271	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.061811 (rank : 174)
Query Neighborhood Hits	271	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.062347 (rank : 169)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.071907 (rank : 126)
Query Neighborhood Hits	271	Target Neighborhood Hits	309	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.071580 (rank : 128)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	60
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.071131 (rank : 131)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	60
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRIN1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.053464 (rank : 227)
Query Neighborhood Hits	271	Target Neighborhood Hits	681	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.078276 (rank : 102)
Query Neighborhood Hits	271	Target Neighborhood Hits	358	Shared Neighborhood Hits	82
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.074820 (rank : 117)
Query Neighborhood Hits	271	Target Neighborhood Hits	329	Shared Neighborhood Hits	76
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.057410 (rank : 206)
Query Neighborhood Hits	271	Target Neighborhood Hits	1024	Shared Neighborhood Hits	123
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITSN1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.059253 (rank : 194)
Query Neighborhood Hits	271	Target Neighborhood Hits	1757	Shared Neighborhood Hits	111
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.057826 (rank : 202)
Query Neighborhood Hits	271	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.051478 (rank : 242)
Query Neighborhood Hits	271	Target Neighborhood Hits	1173	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

K1802_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.061584 (rank : 179)
Query Neighborhood Hits	271	Target Neighborhood Hits	1596	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LCP2_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.064787 (rank : 156)
Query Neighborhood Hits	271	Target Neighborhood Hits	531	Shared Neighborhood Hits	90
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LPP_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.051730 (rank : 238)
Query Neighborhood Hits	271	Target Neighborhood Hits	775	Shared Neighborhood Hits	92
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MDC1_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.066959 (rank : 148)
Query Neighborhood Hits	271	Target Neighborhood Hits	1446	Shared Neighborhood Hits	107
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.061674 (rank : 177)
Query Neighborhood Hits	271	Target Neighborhood Hits	998	Shared Neighborhood Hits	92
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MILK1_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.052350 (rank : 234)
Query Neighborhood Hits	271	Target Neighborhood Hits	788	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MISS_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.057693 (rank : 203)
Query Neighborhood Hits	271	Target Neighborhood Hits	444	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MLL3_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.051738 (rank : 237)
Query Neighborhood Hits	271	Target Neighborhood Hits	1399	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MUC1_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.084127 (rank : 93)
Query Neighborhood Hits	271	Target Neighborhood Hits	975	Shared Neighborhood Hits	107
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUCDL_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.055645 (rank : 213)
Query Neighborhood Hits	271	Target Neighborhood Hits	777	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

NCF1_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.063545 (rank : 161)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 331)	NC score	0.061325 (rank : 181)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	45
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 332)	NC score	0.071264 (rank : 130)
Query Neighborhood Hits	271	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 333)	NC score	0.074552 (rank : 119)
Query Neighborhood Hits	271	Target Neighborhood Hits	177	Shared Neighborhood Hits	42
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCOA6_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.069571 (rank : 137)
Query Neighborhood Hits	271	Target Neighborhood Hits	1202	Shared Neighborhood Hits	117
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCOA6_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.052896 (rank : 231)
Query Neighborhood Hits	271	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NEBU_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.062325 (rank : 170)
Query Neighborhood Hits	271	Target Neighborhood Hits	420	Shared Neighborhood Hits	53
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.066669 (rank : 150)
Query Neighborhood Hits	271	Target Neighborhood Hits	166	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

OGFR_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.092368 (rank : 74)
Query Neighborhood Hits	271	Target Neighborhood Hits	1582	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PACN1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.068924 (rank : 141)
Query Neighborhood Hits	271	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.068565 (rank : 142)
Query Neighborhood Hits	271	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.062633 (rank : 166)
Query Neighborhood Hits	271	Target Neighborhood Hits	339	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.067761 (rank : 146)
Query Neighborhood Hits	271	Target Neighborhood Hits	382	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.062065 (rank : 172)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.061644 (rank : 178)
Query Neighborhood Hits	271	Target Neighborhood Hits	380	Shared Neighborhood Hits	52
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCLO_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.058270 (rank : 200)
Query Neighborhood Hits	271	Target Neighborhood Hits	2046	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.056554 (rank : 209)
Query Neighborhood Hits	271	Target Neighborhood Hits	2275	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PEX13_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.051074 (rank : 248)
Query Neighborhood Hits	271	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PI5PA_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.050714 (rank : 250)
Query Neighborhood Hits	271	Target Neighborhood Hits	749	Shared Neighborhood Hits	97
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PRP1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.053782 (rank : 223)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	43
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PRRT3_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.091968 (rank : 75)
Query Neighborhood Hits	271	Target Neighborhood Hits	998	Shared Neighborhood Hits	124
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PSL1_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.053763 (rank : 224)
Query Neighborhood Hits	271	Target Neighborhood Hits	650	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PYGO2_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.052760 (rank : 233)
Query Neighborhood Hits	271	Target Neighborhood Hits	189	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

RIMB2_HUMAN
θ value	θ > 10 (rank : 353)	NC score	0.050601 (rank : 251)
Query Neighborhood Hits	271	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.051889 (rank : 236)
Query Neighborhood Hits	271	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SAPS1_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.067330 (rank : 147)
Query Neighborhood Hits	271	Target Neighborhood Hits	704	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SHC3_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.055868 (rank : 212)
Query Neighborhood Hits	271	Target Neighborhood Hits	155	Shared Neighborhood Hits	26
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHLB1_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.050790 (rank : 249)
Query Neighborhood Hits	271	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SNPC4_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.057485 (rank : 204)
Query Neighborhood Hits	271	Target Neighborhood Hits	589	Shared Neighborhood Hits	88
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SNX18_HUMAN
θ value	θ > 10 (rank : 359)	NC score	0.073746 (rank : 123)
Query Neighborhood Hits	271	Target Neighborhood Hits	207	Shared Neighborhood Hits	49
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	θ > 10 (rank : 360)	NC score	0.075236 (rank : 115)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SON_HUMAN
θ value	θ > 10 (rank : 361)	NC score	0.091700 (rank : 76)
Query Neighborhood Hits	271	Target Neighborhood Hits	1568	Shared Neighborhood Hits	127
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPN90_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.050600 (rank : 252)
Query Neighborhood Hits	271	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.058356 (rank : 199)
Query Neighborhood Hits	271	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRC8_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.071534 (rank : 129)
Query Neighborhood Hits	271	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.071717 (rank : 127)
Query Neighborhood Hits	271	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRRM2_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.061771 (rank : 175)
Query Neighborhood Hits	271	Target Neighborhood Hits	1296	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SSBP4_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.054431 (rank : 220)
Query Neighborhood Hits	271	Target Neighborhood Hits	753	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
θ value	θ > 10 (rank : 368)	NC score	0.054398 (rank : 221)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.053761 (rank : 225)
Query Neighborhood Hits	271	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.054744 (rank : 218)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.054925 (rank : 216)
Query Neighborhood Hits	271	Target Neighborhood Hits	273	Shared Neighborhood Hits	48
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.054910 (rank : 217)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.054436 (rank : 219)
Query Neighborhood Hits	271	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SYN3_MOUSE
θ value	θ > 10 (rank : 374)	NC score	0.058012 (rank : 201)
Query Neighborhood Hits	271	Target Neighborhood Hits	200	Shared Neighborhood Hits	26
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TARSH_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.058881 (rank : 196)
Query Neighborhood Hits	271	Target Neighborhood Hits	768	Shared Neighborhood Hits	88
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.062266 (rank : 171)
Query Neighborhood Hits	271	Target Neighborhood Hits	872	Shared Neighborhood Hits	121
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VAV2_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.050264 (rank : 255)
Query Neighborhood Hits	271	Target Neighborhood Hits	453	Shared Neighborhood Hits	62
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.053676 (rank : 226)
Query Neighborhood Hits	271	Target Neighborhood Hits	452	Shared Neighborhood Hits	61
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.058664 (rank : 197)
Query Neighborhood Hits	271	Target Neighborhood Hits	430	Shared Neighborhood Hits	62
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WASP_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.053088 (rank : 230)
Query Neighborhood Hits	271	Target Neighborhood Hits	195	Shared Neighborhood Hits	24
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

WASP_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.053137 (rank : 229)
Query Neighborhood Hits	271	Target Neighborhood Hits	223	Shared Neighborhood Hits	29
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

Hits sorted by NC score

JIP1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	271
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
NC score	0.970664 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	271	Target Neighborhood Hits	259	Shared Neighborhood Hits	183
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_MOUSE
NC score	0.845016 (rank : 3)	θ value	1.26366e-94 (rank : 4)
Query Neighborhood Hits	271	Target Neighborhood Hits	144	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_HUMAN
NC score	0.837558 (rank : 4)	θ value	1.94955e-95 (rank : 3)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	89
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

VINEX_MOUSE
NC score	0.236230 (rank : 5)	θ value	0.000270298 (rank : 5)
Query Neighborhood Hits	271	Target Neighborhood Hits	286	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ARH_MOUSE
NC score	0.236031 (rank : 6)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	271	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

NUMBL_HUMAN
NC score	0.233743 (rank : 7)	θ value	0.000461057 (rank : 7)
Query Neighborhood Hits	271	Target Neighborhood Hits	394	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

VINEX_HUMAN
NC score	0.232740 (rank : 8)	θ value	0.00035302 (rank : 6)
Query Neighborhood Hits	271	Target Neighborhood Hits	270	Shared Neighborhood Hits	63
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

NUMBL_MOUSE
NC score	0.228240 (rank : 9)	θ value	0.000461057 (rank : 8)
Query Neighborhood Hits	271	Target Neighborhood Hits	147	Shared Neighborhood Hits	43
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

ARH_HUMAN
NC score	0.224156 (rank : 10)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	271	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

SRBS1_HUMAN
NC score	0.216395 (rank : 11)	θ value	0.00665767 (rank : 22)
Query Neighborhood Hits	271	Target Neighborhood Hits	396	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CAPON_HUMAN
NC score	0.214949 (rank : 12)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	271	Target Neighborhood Hits	35	Shared Neighborhood Hits	18
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

SRBS1_MOUSE
NC score	0.212137 (rank : 13)	θ value	0.00509761 (rank : 19)
Query Neighborhood Hits	271	Target Neighborhood Hits	409	Shared Neighborhood Hits	74
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

CAPON_MOUSE
NC score	0.207792 (rank : 14)	θ value	0.00228821 (rank : 13)
Query Neighborhood Hits	271	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

NUMB_MOUSE
NC score	0.204153 (rank : 15)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	271	Target Neighborhood Hits	91	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

NUMB_HUMAN
NC score	0.203664 (rank : 16)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	271	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

STS2_HUMAN
NC score	0.198592 (rank : 17)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	271	Target Neighborhood Hits	108	Shared Neighborhood Hits	44
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

PPIP1_HUMAN
NC score	0.152944 (rank : 18)	θ value	0.0148317 (rank : 28)
Query Neighborhood Hits	271	Target Neighborhood Hits	389	Shared Neighborhood Hits	59
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CD2AP_HUMAN
NC score	0.150565 (rank : 19)	θ value	0.0330416 (rank : 36)
Query Neighborhood Hits	271	Target Neighborhood Hits	315	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

PPIP1_MOUSE
NC score	0.148958 (rank : 20)	θ value	0.0113563 (rank : 25)
Query Neighborhood Hits	271	Target Neighborhood Hits	377	Shared Neighborhood Hits	59
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

ARHG5_HUMAN
NC score	0.143045 (rank : 21)	θ value	0.00228821 (rank : 12)
Query Neighborhood Hits	271	Target Neighborhood Hits	172	Shared Neighborhood Hits	54
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

LASP1_MOUSE
NC score	0.139795 (rank : 22)	θ value	0.62314 (rank : 88)
Query Neighborhood Hits	271	Target Neighborhood Hits	297	Shared Neighborhood Hits	58
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_HUMAN
NC score	0.139351 (rank : 23)	θ value	0.62314 (rank : 87)
Query Neighborhood Hits	271	Target Neighborhood Hits	293	Shared Neighborhood Hits	58
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NCF2_HUMAN
NC score	0.136618 (rank : 24)	θ value	1.06291 (rank : 121)
Query Neighborhood Hits	271	Target Neighborhood Hits	229	Shared Neighborhood Hits	57
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

CIC_HUMAN
NC score	0.127920 (rank : 25)	θ value	0.000602161 (rank : 9)
Query Neighborhood Hits	271	Target Neighborhood Hits	992	Shared Neighborhood Hits	100
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

RGS3_MOUSE
NC score	0.127316 (rank : 26)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	271	Target Neighborhood Hits	1621	Shared Neighborhood Hits	142
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

OSTF1_HUMAN
NC score	0.126954 (rank : 27)	θ value	0.0563607 (rank : 41)
Query Neighborhood Hits	271	Target Neighborhood Hits	466	Shared Neighborhood Hits	65
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SRRM1_MOUSE
NC score	0.126637 (rank : 28)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	271	Target Neighborhood Hits	966	Shared Neighborhood Hits	90
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SH3K1_MOUSE
NC score	0.120894 (rank : 29)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	271	Target Neighborhood Hits	332	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

APBB2_HUMAN
NC score	0.120677 (rank : 30)	θ value	0.00509761 (rank : 18)
Query Neighborhood Hits	271	Target Neighborhood Hits	96	Shared Neighborhood Hits	18
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

OSTF1_MOUSE
NC score	0.119366 (rank : 31)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	271	Target Neighborhood Hits	467	Shared Neighborhood Hits	65
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SH3K1_HUMAN
NC score	0.117650 (rank : 32)	θ value	1.81305 (rank : 149)
Query Neighborhood Hits	271	Target Neighborhood Hits	341	Shared Neighborhood Hits	71
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3G3_MOUSE
NC score	0.116988 (rank : 33)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	271	Target Neighborhood Hits	236	Shared Neighborhood Hits	54
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

NEBL_HUMAN
NC score	0.116868 (rank : 34)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	271	Target Neighborhood Hits	457	Shared Neighborhood Hits	59
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

APBA1_HUMAN
NC score	0.116486 (rank : 35)	θ value	0.0252991 (rank : 32)
Query Neighborhood Hits	271	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

SH3G2_HUMAN
NC score	0.116181 (rank : 36)	θ value	0.47712 (rank : 78)
Query Neighborhood Hits	271	Target Neighborhood Hits	324	Shared Neighborhood Hits	54
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

APBB2_MOUSE
NC score	0.115746 (rank : 37)	θ value	0.00869519 (rank : 23)
Query Neighborhood Hits	271	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

STAC_MOUSE
NC score	0.114619 (rank : 38)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	271	Target Neighborhood Hits	268	Shared Neighborhood Hits	55
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH3G3_HUMAN
NC score	0.113878 (rank : 39)	θ value	1.38821 (rank : 139)
Query Neighborhood Hits	271	Target Neighborhood Hits	222	Shared Neighborhood Hits	52
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ANKS1_MOUSE
NC score	0.113727 (rank : 40)	θ value	0.00175202 (rank : 11)
Query Neighborhood Hits	271	Target Neighborhood Hits	453	Shared Neighborhood Hits	37
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

DNMBP_HUMAN
NC score	0.112413 (rank : 41)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	271	Target Neighborhood Hits	413	Shared Neighborhood Hits	60
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MUC7_HUMAN
NC score	0.112032 (rank : 42)	θ value	0.0563607 (rank : 40)
Query Neighborhood Hits	271	Target Neighborhood Hits	538	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SYN1_HUMAN
NC score	0.111969 (rank : 43)	θ value	0.0113563 (rank : 27)
Query Neighborhood Hits	271	Target Neighborhood Hits	419	Shared Neighborhood Hits	45
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SH3G1_HUMAN
NC score	0.111883 (rank : 44)	θ value	1.06291 (rank : 124)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_MOUSE
NC score	0.111839 (rank : 45)	θ value	1.38821 (rank : 138)
Query Neighborhood Hits	271	Target Neighborhood Hits	319	Shared Neighborhood Hits	55
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G1_MOUSE
NC score	0.109494 (rank : 46)	θ value	1.81305 (rank : 148)
Query Neighborhood Hits	271	Target Neighborhood Hits	291	Shared Neighborhood Hits	53
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SRRM1_HUMAN
NC score	0.108500 (rank : 47)	θ value	0.0330416 (rank : 37)
Query Neighborhood Hits	271	Target Neighborhood Hits	690	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WASL_HUMAN
NC score	0.108030 (rank : 48)	θ value	0.0330416 (rank : 38)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	33
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

RGS3_HUMAN
NC score	0.107267 (rank : 49)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	271	Target Neighborhood Hits	1375	Shared Neighborhood Hits	128
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

FUT8_HUMAN
NC score	0.106832 (rank : 50)	θ value	1.06291 (rank : 115)
Query Neighborhood Hits	271	Target Neighborhood Hits	67	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

ANKS1_HUMAN
NC score	0.106519 (rank : 51)	θ value	0.00175202 (rank : 10)
Query Neighborhood Hits	271	Target Neighborhood Hits	438	Shared Neighborhood Hits	35
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

STS1_HUMAN
NC score	0.106388 (rank : 52)	θ value	1.81305 (rank : 151)
Query Neighborhood Hits	271	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SRRM2_MOUSE
NC score	0.106329 (rank : 53)	θ value	0.0193708 (rank : 31)
Query Neighborhood Hits	271	Target Neighborhood Hits	1470	Shared Neighborhood Hits	102
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CIC_MOUSE
NC score	0.104954 (rank : 54)	θ value	0.0193708 (rank : 30)
Query Neighborhood Hits	271	Target Neighborhood Hits	742	Shared Neighborhood Hits	76
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

WASL_MOUSE
NC score	0.103524 (rank : 55)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	271	Target Neighborhood Hits	339	Shared Neighborhood Hits	34
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

WASIP_HUMAN
NC score	0.103094 (rank : 56)	θ value	1.06291 (rank : 130)
Query Neighborhood Hits	271	Target Neighborhood Hits	458	Shared Neighborhood Hits	45
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

STS1_MOUSE
NC score	0.102496 (rank : 57)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	271	Target Neighborhood Hits	104	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

DNMBP_MOUSE
NC score	0.102456 (rank : 58)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	71
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

STAC_HUMAN
NC score	0.102274 (rank : 59)	θ value	1.06291 (rank : 127)
Query Neighborhood Hits	271	Target Neighborhood Hits	276	Shared Neighborhood Hits	57
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

AKAP1_MOUSE
NC score	0.101739 (rank : 60)	θ value	0.00298849 (rank : 14)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	20
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

DAB1_HUMAN
NC score	0.101648 (rank : 61)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	271	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

APBA2_HUMAN
NC score	0.101578 (rank : 62)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	271	Target Neighborhood Hits	220	Shared Neighborhood Hits	23
SwissProt Accessions	Q99767, O60571	Gene names	APBA2, MINT2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

APBA2_MOUSE
NC score	0.100992 (rank : 63)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	271	Target Neighborhood Hits	219	Shared Neighborhood Hits	20
SwissProt Accessions	P98084, Q6PAJ2	Gene names	Apba2, X11l
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta).

CD2AP_MOUSE
NC score	0.100768 (rank : 64)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	271	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

FUT8_MOUSE
NC score	0.100598 (rank : 65)	θ value	1.06291 (rank : 116)
Query Neighborhood Hits	271	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

DAB1_MOUSE
NC score	0.100355 (rank : 66)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	271	Target Neighborhood Hits	145	Shared Neighborhood Hits	31
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

EFS_HUMAN
NC score	0.097295 (rank : 67)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	271	Target Neighborhood Hits	348	Shared Neighborhood Hits	76
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

NACAM_MOUSE
NC score	0.096148 (rank : 68)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	271	Target Neighborhood Hits	1866	Shared Neighborhood Hits	138
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

APBA3_MOUSE
NC score	0.095498 (rank : 69)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	271	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	O88888	Gene names	Apba3, Mint3
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

MAGE1_HUMAN
NC score	0.093756 (rank : 70)	θ value	0.0961366 (rank : 45)
Query Neighborhood Hits	271	Target Neighborhood Hits	1389	Shared Neighborhood Hits	128
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CRK_MOUSE
NC score	0.093737 (rank : 71)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	271	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.093068 (rank : 72)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	271	Target Neighborhood Hits	308	Shared Neighborhood Hits	60
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

APBA3_HUMAN
NC score	0.092714 (rank : 73)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	271	Target Neighborhood Hits	201	Shared Neighborhood Hits	22
SwissProt Accessions	O96018, O60483	Gene names	APBA3, MINT3, X11L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 3 (Neuron- specific X11L2 protein) (Neuronal Munc18-1-interacting protein 3) (Mint-3) (Adapter protein X11gamma).

OGFR_HUMAN
NC score	0.092368 (rank : 74)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	271	Target Neighborhood Hits	1582	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PRRT3_HUMAN
NC score	0.091968 (rank : 75)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	271	Target Neighborhood Hits	998	Shared Neighborhood Hits	124
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SON_HUMAN
NC score	0.091700 (rank : 76)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	271	Target Neighborhood Hits	1568	Shared Neighborhood Hits	127
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

EFS_MOUSE
NC score	0.091700 (rank : 77)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	271	Target Neighborhood Hits	389	Shared Neighborhood Hits	92
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

SHC1_MOUSE
NC score	0.090649 (rank : 78)	θ value	0.47712 (rank : 80)
Query Neighborhood Hits	271	Target Neighborhood Hits	180	Shared Neighborhood Hits	38
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

DP13A_MOUSE
NC score	0.090066 (rank : 79)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	271	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_HUMAN
NC score	0.089347 (rank : 80)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	271	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

ABI2_HUMAN
NC score	0.089110 (rank : 81)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GSCR1_HUMAN
NC score	0.089075 (rank : 82)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	271	Target Neighborhood Hits	674	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HNRL1_MOUSE
NC score	0.088989 (rank : 83)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	271	Target Neighborhood Hits	200	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

ARHGG_MOUSE
NC score	0.088680 (rank : 84)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	271	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SHC1_HUMAN
NC score	0.088262 (rank : 85)	θ value	0.47712 (rank : 79)
Query Neighborhood Hits	271	Target Neighborhood Hits	170	Shared Neighborhood Hits	32
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

PRP2_MOUSE
NC score	0.088001 (rank : 86)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	271	Target Neighborhood Hits	347	Shared Neighborhood Hits	32
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

TAF4_HUMAN
NC score	0.087625 (rank : 87)	θ value	1.06291 (rank : 129)
Query Neighborhood Hits	271	Target Neighborhood Hits	687	Shared Neighborhood Hits	56
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

YLPM1_HUMAN
NC score	0.087111 (rank : 88)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	271	Target Neighborhood Hits	670	Shared Neighborhood Hits	71
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

WIRE_MOUSE
NC score	0.085420 (rank : 89)	θ value	1.38821 (rank : 140)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ARHG7_MOUSE
NC score	0.085225 (rank : 90)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	271	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.085050 (rank : 91)	θ value	1.38821 (rank : 135)
Query Neighborhood Hits	271	Target Neighborhood Hits	347	Shared Neighborhood Hits	58
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

HNRL1_HUMAN
NC score	0.084793 (rank : 92)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	271	Target Neighborhood Hits	173	Shared Neighborhood Hits	16
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

MUC1_HUMAN
NC score	0.084127 (rank : 93)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	271	Target Neighborhood Hits	975	Shared Neighborhood Hits	107
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SHC2_MOUSE
NC score	0.084066 (rank : 94)	θ value	1.06291 (rank : 125)
Query Neighborhood Hits	271	Target Neighborhood Hits	144	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

WIRE_HUMAN
NC score	0.083872 (rank : 95)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	271	Target Neighborhood Hits	329	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ABI2_MOUSE
NC score	0.083801 (rank : 96)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	271	Target Neighborhood Hits	266	Shared Neighborhood Hits	63
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SC24C_HUMAN
NC score	0.082695 (rank : 97)	θ value	1.06291 (rank : 123)
Query Neighborhood Hits	271	Target Neighborhood Hits	662	Shared Neighborhood Hits	86
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

APBB1_HUMAN
NC score	0.082534 (rank : 98)	θ value	1.38821 (rank : 133)
Query Neighborhood Hits	271	Target Neighborhood Hits	62	Shared Neighborhood Hits	18
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.081784 (rank : 99)	θ value	1.38821 (rank : 134)
Query Neighborhood Hits	271	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

DP13B_HUMAN
NC score	0.080274 (rank : 100)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	271	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

SON_MOUSE
NC score	0.079720 (rank : 101)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	271	Target Neighborhood Hits	957	Shared Neighborhood Hits	86
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

HCLS1_HUMAN
NC score	0.078276 (rank : 102)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	271	Target Neighborhood Hits	358	Shared Neighborhood Hits	82
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SYN1_MOUSE
NC score	0.077966 (rank : 103)	θ value	8.99809 (rank : 268)
Query Neighborhood Hits	271	Target Neighborhood Hits	363	Shared Neighborhood Hits	41
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

ABI3_HUMAN
NC score	0.077596 (rank : 104)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	271	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PARM1_MOUSE
NC score	0.077487 (rank : 105)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	271	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

MBD6_HUMAN
NC score	0.076817 (rank : 106)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	271	Target Neighborhood Hits	349	Shared Neighborhood Hits	39
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

BCAR1_HUMAN
NC score	0.076778 (rank : 107)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	271	Target Neighborhood Hits	554	Shared Neighborhood Hits	109
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

FMN1A_MOUSE
NC score	0.076662 (rank : 108)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	271	Target Neighborhood Hits	423	Shared Neighborhood Hits	45
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

NGEF_MOUSE
NC score	0.076322 (rank : 109)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BSN_MOUSE
NC score	0.076318 (rank : 110)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	271	Target Neighborhood Hits	2057	Shared Neighborhood Hits	142
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

SHC2_HUMAN
NC score	0.076103 (rank : 111)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	271	Target Neighborhood Hits	170	Shared Neighborhood Hits	35
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

DOCK1_HUMAN
NC score	0.076081 (rank : 112)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	271	Target Neighborhood Hits	191	Shared Neighborhood Hits	38
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

WASIP_MOUSE
NC score	0.075993 (rank : 113)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	271	Target Neighborhood Hits	392	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

CCNK_MOUSE
NC score	0.075655 (rank : 114)	θ value	0.0330416 (rank : 35)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

SNX18_MOUSE
NC score	0.075236 (rank : 115)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

NCK2_HUMAN
NC score	0.074943 (rank : 116)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

HCLS1_MOUSE
NC score	0.074820 (rank : 117)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	271	Target Neighborhood Hits	329	Shared Neighborhood Hits	76
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

DP13B_MOUSE
NC score	0.074746 (rank : 118)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	271	Target Neighborhood Hits	58	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

NCF4_MOUSE
NC score	0.074552 (rank : 119)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	271	Target Neighborhood Hits	177	Shared Neighborhood Hits	42
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
NC score	0.074340 (rank : 120)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	61
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ARHG6_HUMAN
NC score	0.074287 (rank : 121)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	271	Target Neighborhood Hits	376	Shared Neighborhood Hits	56
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

IRX5_MOUSE
NC score	0.073902 (rank : 122)	θ value	0.0431538 (rank : 39)
Query Neighborhood Hits	271	Target Neighborhood Hits	324	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKQ4, Q80WV4, Q9JLL5	Gene names	Irx5, Irxb2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2).

SNX18_HUMAN
NC score	0.073746 (rank : 123)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	271	Target Neighborhood Hits	207	Shared Neighborhood Hits	49
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

FMN1B_MOUSE
NC score	0.073182 (rank : 124)	θ value	1.06291 (rank : 114)
Query Neighborhood Hits	271	Target Neighborhood Hits	447	Shared Neighborhood Hits	40
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

TARA_HUMAN
NC score	0.072373 (rank : 125)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	271	Target Neighborhood Hits	1626	Shared Neighborhood Hits	103
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

GRAP_MOUSE
NC score	0.071907 (rank : 126)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	271	Target Neighborhood Hits	309	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

SRC8_MOUSE
NC score	0.071717 (rank : 127)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	271	Target Neighborhood Hits	292	Shared Neighborhood Hits	61
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

GRB2_HUMAN
NC score	0.071580 (rank : 128)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	271	Target Neighborhood Hits	310	Shared Neighborhood Hits	60
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SRC8_HUMAN
NC score	0.071534 (rank : 129)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	271	Target Neighborhood Hits	269	Shared Neighborhood Hits	58
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

NCF4_HUMAN
NC score	0.071264 (rank : 130)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	271	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

GRB2_MOUSE
NC score	0.071131 (rank : 131)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	271	Target Neighborhood Hits	312	Shared Neighborhood Hits	60
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI1_MOUSE
NC score	0.071066 (rank : 132)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	271	Target Neighborhood Hits	246	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_MOUSE
NC score	0.070635 (rank : 133)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	271	Target Neighborhood Hits	227	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI1_HUMAN
NC score	0.070467 (rank : 134)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	271	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

CRKL_HUMAN
NC score	0.070189 (rank : 135)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	271	Target Neighborhood Hits	313	Shared Neighborhood Hits	58
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRSP2_HUMAN
NC score	0.069996 (rank : 136)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	271	Target Neighborhood Hits	380	Shared Neighborhood Hits	51
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

NCOA6_HUMAN
NC score	0.069571 (rank : 137)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	271	Target Neighborhood Hits	1202	Shared Neighborhood Hits	117
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

BCL9_HUMAN
NC score	0.069299 (rank : 138)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	271	Target Neighborhood Hits	1008	Shared Neighborhood Hits	106
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

RAPH1_HUMAN
NC score	0.069258 (rank : 139)	θ value	1.81305 (rank : 147)
Query Neighborhood Hits	271	Target Neighborhood Hits	593	Shared Neighborhood Hits	70
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

CRKL_MOUSE
NC score	0.068958 (rank : 140)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

PACN1_HUMAN
NC score	0.068924 (rank : 141)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	271	Target Neighborhood Hits	320	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
NC score	0.068565 (rank : 142)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	271	Target Neighborhood Hits	283	Shared Neighborhood Hits	55
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PRR12_HUMAN
NC score	0.068462 (rank : 143)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	271	Target Neighborhood Hits	460	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

ARHG6_MOUSE
NC score	0.068362 (rank : 144)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	271	Target Neighborhood Hits	394	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ATN1_HUMAN
NC score	0.068111 (rank : 145)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	271	Target Neighborhood Hits	676	Shared Neighborhood Hits	55
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

PACN2_MOUSE
NC score	0.067761 (rank : 146)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	271	Target Neighborhood Hits	382	Shared Neighborhood Hits	61
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SAPS1_HUMAN
NC score	0.067330 (rank : 147)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	271	Target Neighborhood Hits	704	Shared Neighborhood Hits	100
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

MDC1_HUMAN
NC score	0.066959 (rank : 148)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	271	Target Neighborhood Hits	1446	Shared Neighborhood Hits	107
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

DAB2_HUMAN
NC score	0.066815 (rank : 149)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	271	Target Neighborhood Hits	197	Shared Neighborhood Hits	40
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

NGEF_HUMAN
NC score	0.066669 (rank : 150)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	271	Target Neighborhood Hits	166	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

GGN_HUMAN
NC score	0.066216 (rank : 151)	θ value	1.38821 (rank : 136)
Query Neighborhood Hits	271	Target Neighborhood Hits	269	Shared Neighborhood Hits	34
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

P85A_MOUSE
NC score	0.065573 (rank : 152)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	49
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BCAR1_MOUSE
NC score	0.065491 (rank : 153)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	271	Target Neighborhood Hits	438	Shared Neighborhood Hits	94
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

YLPM1_MOUSE
NC score	0.065242 (rank : 154)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	271	Target Neighborhood Hits	505	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

DAB2_MOUSE
NC score	0.064885 (rank : 155)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	271	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

LCP2_HUMAN
NC score	0.064787 (rank : 156)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	271	Target Neighborhood Hits	531	Shared Neighborhood Hits	90
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MLL3_HUMAN
NC score	0.064663 (rank : 157)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	271	Target Neighborhood Hits	1644	Shared Neighborhood Hits	120
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

RERE_MOUSE
NC score	0.064105 (rank : 158)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	271	Target Neighborhood Hits	785	Shared Neighborhood Hits	58
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RIMB1_HUMAN
NC score	0.063965 (rank : 159)	θ value	0.365318 (rank : 65)
Query Neighborhood Hits	271	Target Neighborhood Hits	1479	Shared Neighborhood Hits	101
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

ARHGF_HUMAN
NC score	0.063587 (rank : 160)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	271	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NCF1_HUMAN
NC score	0.063545 (rank : 161)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

WASF2_MOUSE
NC score	0.063394 (rank : 162)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	271	Target Neighborhood Hits	315	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

CT175_HUMAN
NC score	0.063248 (rank : 163)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	271	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q96MK2, Q5QPB6, Q9NQQ2	Gene names	C20orf175
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf175.

DDEF2_HUMAN
NC score	0.063085 (rank : 164)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	271	Target Neighborhood Hits	599	Shared Neighborhood Hits	68
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

PRB4S_HUMAN
NC score	0.062944 (rank : 165)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	271	Target Neighborhood Hits	330	Shared Neighborhood Hits	34
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PACN2_HUMAN
NC score	0.062633 (rank : 166)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	271	Target Neighborhood Hits	339	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

BAT2_HUMAN
NC score	0.062611 (rank : 167)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	271	Target Neighborhood Hits	931	Shared Neighborhood Hits	87
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAT2_MOUSE
NC score	0.062516 (rank : 168)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	271	Target Neighborhood Hits	947	Shared Neighborhood Hits	96
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

GRAP_HUMAN
NC score	0.062347 (rank : 169)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	271	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NEBU_HUMAN
NC score	0.062325 (rank : 170)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	271	Target Neighborhood Hits	420	Shared Neighborhood Hits	53
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

TCGAP_HUMAN
NC score	0.062266 (rank : 171)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	271	Target Neighborhood Hits	872	Shared Neighborhood Hits	121
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PACN3_HUMAN
NC score	0.062065 (rank : 172)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

DDEF2_MOUSE
NC score	0.061944 (rank : 173)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	271	Target Neighborhood Hits	625	Shared Neighborhood Hits	65
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP2_MOUSE
NC score	0.061811 (rank : 174)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	271	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SRRM2_HUMAN
NC score	0.061771 (rank : 175)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	271	Target Neighborhood Hits	1296	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

NFH_MOUSE
NC score	0.061696 (rank : 176)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	271	Target Neighborhood Hits	2247	Shared Neighborhood Hits	124
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MDC1_MOUSE
NC score	0.061674 (rank : 177)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	271	Target Neighborhood Hits	998	Shared Neighborhood Hits	92
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PACN3_MOUSE
NC score	0.061644 (rank : 178)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	271	Target Neighborhood Hits	380	Shared Neighborhood Hits	52
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

K1802_MOUSE
NC score	0.061584 (rank : 179)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	271	Target Neighborhood Hits	1596	Shared Neighborhood Hits	122
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SYN2_HUMAN
NC score	0.061512 (rank : 180)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	271	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	Q92777	Gene names	SYN2
Domain Architecture
Description	Synapsin-2 (Synapsin II).

NCF1_MOUSE
NC score	0.061325 (rank : 181)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	271	Target Neighborhood Hits	198	Shared Neighborhood Hits	45
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

FA47B_HUMAN
NC score	0.061070 (rank : 182)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	271	Target Neighborhood Hits	431	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

WASF4_HUMAN
NC score	0.060354 (rank : 183)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	271	Target Neighborhood Hits	282	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

GRAP2_HUMAN
NC score	0.060212 (rank : 184)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	271	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

FMNL_HUMAN
NC score	0.060092 (rank : 185)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	271	Target Neighborhood Hits	529	Shared Neighborhood Hits	34
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

DIAP1_MOUSE
NC score	0.060034 (rank : 186)	θ value	0.0961366 (rank : 44)
Query Neighborhood Hits	271	Target Neighborhood Hits	839	Shared Neighborhood Hits	32
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

CEL_HUMAN
NC score	0.059945 (rank : 187)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	271	Target Neighborhood Hits	896	Shared Neighborhood Hits	93
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

DIAP1_HUMAN
NC score	0.059800 (rank : 188)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	271	Target Neighborhood Hits	784	Shared Neighborhood Hits	44
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

3BP2_HUMAN
NC score	0.059661 (rank : 189)	θ value	1.38821 (rank : 132)
Query Neighborhood Hits	271	Target Neighborhood Hits	296	Shared Neighborhood Hits	48
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

FMN2_MOUSE
NC score	0.059550 (rank : 190)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	271	Target Neighborhood Hits	349	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

ASPP1_MOUSE
NC score	0.059463 (rank : 191)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	271	Target Neighborhood Hits	1244	Shared Neighborhood Hits	124
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DBNL_MOUSE
NC score	0.059421 (rank : 192)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	271	Target Neighborhood Hits	306	Shared Neighborhood Hits	48
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

ENAH_MOUSE
NC score	0.059265 (rank : 193)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	271	Target Neighborhood Hits	919	Shared Neighborhood Hits	55
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

ITSN1_HUMAN
NC score	0.059253 (rank : 194)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	271	Target Neighborhood Hits	1757	Shared Neighborhood Hits	111
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SHC3_MOUSE
NC score	0.059063 (rank : 195)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	28
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

TARSH_HUMAN
NC score	0.058881 (rank : 196)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	271	Target Neighborhood Hits	768	Shared Neighborhood Hits	88
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

VAV_MOUSE
NC score	0.058664 (rank : 197)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	271	Target Neighborhood Hits	430	Shared Neighborhood Hits	62
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DBNL_HUMAN
NC score	0.058476 (rank : 198)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	271	Target Neighborhood Hits	244	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

SPN90_MOUSE
NC score	0.058356 (rank : 199)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	271	Target Neighborhood Hits	157	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

PCLO_HUMAN
NC score	0.058270 (rank : 200)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	271	Target Neighborhood Hits	2046	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SYN3_MOUSE
NC score	0.058012 (rank : 201)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	271	Target Neighborhood Hits	200	Shared Neighborhood Hits	26
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

ITSN1_MOUSE
NC score	0.057826 (rank : 202)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	271	Target Neighborhood Hits	1669	Shared Neighborhood Hits	101
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MISS_MOUSE
NC score	0.057693 (rank : 203)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	271	Target Neighborhood Hits	444	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

SNPC4_HUMAN
NC score	0.057485 (rank : 204)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	271	Target Neighborhood Hits	589	Shared Neighborhood Hits	88
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

CO039_MOUSE
NC score	0.057445 (rank : 205)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	271	Target Neighborhood Hits	445	Shared Neighborhood Hits	74
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

IASPP_MOUSE
NC score	0.057410 (rank : 206)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	271	Target Neighborhood Hits	1024	Shared Neighborhood Hits	123
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BSN_HUMAN
NC score	0.057226 (rank : 207)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	271	Target Neighborhood Hits	1537	Shared Neighborhood Hits	105
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

FA47A_HUMAN
NC score	0.057049 (rank : 208)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	271	Target Neighborhood Hits	451	Shared Neighborhood Hits	68
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

PCLO_MOUSE
NC score	0.056554 (rank : 209)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	271	Target Neighborhood Hits	2275	Shared Neighborhood Hits	148
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

P85A_HUMAN
NC score	0.056036 (rank : 210)	θ value	2.36792 (rank : 158)
Query Neighborhood Hits	271	Target Neighborhood Hits	479	Shared Neighborhood Hits	49
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CT032_HUMAN
NC score	0.056032 (rank : 211)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	271	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

SHC3_HUMAN
NC score	0.055868 (rank : 212)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	271	Target Neighborhood Hits	155	Shared Neighborhood Hits	26
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

MUCDL_HUMAN
NC score	0.055645 (rank : 213)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	271	Target Neighborhood Hits	777	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

CN155_HUMAN
NC score	0.055450 (rank : 214)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	35
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CK024_HUMAN
NC score	0.055037 (rank : 215)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	271	Target Neighborhood Hits	408	Shared Neighborhood Hits	64
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

STAM1_MOUSE
NC score	0.054925 (rank : 216)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	271	Target Neighborhood Hits	273	Shared Neighborhood Hits	48
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
NC score	0.054910 (rank : 217)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM1_HUMAN
NC score	0.054744 (rank : 218)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	48
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_MOUSE
NC score	0.054436 (rank : 219)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	271	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SSBP4_HUMAN
NC score	0.054431 (rank : 220)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	271	Target Neighborhood Hits	753	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
NC score	0.054398 (rank : 221)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	44
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CI079_HUMAN
NC score	0.054043 (rank : 222)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	271	Target Neighborhood Hits	288	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

PRP1_HUMAN
NC score	0.053782 (rank : 223)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	271	Target Neighborhood Hits	385	Shared Neighborhood Hits	43
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

PSL1_HUMAN
NC score	0.053763 (rank : 224)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	271	Target Neighborhood Hits	650	Shared Neighborhood Hits	90
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

STAC3_MOUSE
NC score	0.053761 (rank : 225)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	271	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

VAV_HUMAN
NC score	0.053676 (rank : 226)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	271	Target Neighborhood Hits	452	Shared Neighborhood Hits	61
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

GRIN1_HUMAN
NC score	0.053464 (rank : 227)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	271	Target Neighborhood Hits	681	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

WASF2_HUMAN
NC score	0.053153 (rank : 228)	θ value	8.99809 (rank : 271)
Query Neighborhood Hits	271	Target Neighborhood Hits	280	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

WASP_MOUSE
NC score	0.053137 (rank : 229)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	271	Target Neighborhood Hits	223	Shared Neighborhood Hits	29
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

WASP_HUMAN
NC score	0.053088 (rank : 230)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	271	Target Neighborhood Hits	195	Shared Neighborhood Hits	24
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

NCOA6_MOUSE
NC score	0.052896 (rank : 231)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	271	Target Neighborhood Hits	1076	Shared Neighborhood Hits	99
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ARI1A_HUMAN
NC score	0.052774 (rank : 232)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	271	Target Neighborhood Hits	787	Shared Neighborhood Hits	82
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

PYGO2_HUMAN
NC score	0.052760 (rank : 233)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	271	Target Neighborhood Hits	189	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

MILK1_MOUSE
NC score	0.052350 (rank : 234)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	271	Target Neighborhood Hits	788	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

TMAP1_HUMAN
NC score	0.052074 (rank : 235)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	271	Target Neighborhood Hits	140	Shared Neighborhood Hits	18
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

RIMB2_MOUSE
NC score	0.051889 (rank : 236)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	271	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

MLL3_MOUSE
NC score	0.051738 (rank : 237)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	271	Target Neighborhood Hits	1399	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

LPP_HUMAN
NC score	0.051730 (rank : 238)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	271	Target Neighborhood Hits	775	Shared Neighborhood Hits	92
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

CBP_MOUSE
NC score	0.051648 (rank : 239)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	271	Target Neighborhood Hits	1051	Shared Neighborhood Hits	100
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

FMN2_HUMAN
NC score	0.051555 (rank : 240)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	271	Target Neighborhood Hits	484	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

WASF3_HUMAN
NC score	0.051551 (rank : 241)	θ value	0.47712 (rank : 81)
Query Neighborhood Hits	271	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

ITSN2_HUMAN
NC score	0.051478 (rank : 242)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	271	Target Neighborhood Hits	1173	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CD2_HUMAN
NC score	0.051378 (rank : 243)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	271	Target Neighborhood Hits	504	Shared Neighborhood Hits	70
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

IRX5_HUMAN
NC score	0.051346 (rank : 244)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	271	Target Neighborhood Hits	362	Shared Neighborhood Hits	25
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

MLL4_HUMAN
NC score	0.051296 (rank : 245)	θ value	1.38821 (rank : 137)
Query Neighborhood Hits	271	Target Neighborhood Hits	722	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

ELOA2_HUMAN
NC score	0.051189 (rank : 246)	θ value	0.813845 (rank : 95)
Query Neighborhood Hits	271	Target Neighborhood Hits	165	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

BIN1_HUMAN
NC score	0.051141 (rank : 247)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	271	Target Neighborhood Hits	335	Shared Neighborhood Hits	64
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

PEX13_MOUSE
NC score	0.051074 (rank : 248)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	271	Target Neighborhood Hits	126	Shared Neighborhood Hits	42
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SHLB1_MOUSE
NC score	0.050790 (rank : 249)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	271	Target Neighborhood Hits	101	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

PI5PA_HUMAN
NC score	0.050714 (rank : 250)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	271	Target Neighborhood Hits	749	Shared Neighborhood Hits	97
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

RIMB2_HUMAN
NC score	0.050601 (rank : 251)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	271	Target Neighborhood Hits	263	Shared Neighborhood Hits	43
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPN90_HUMAN
NC score	0.050600 (rank : 252)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	271	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

APBB3_HUMAN
NC score	0.050439 (rank : 253)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	271	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.050375 (rank : 254)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	271	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

VAV2_HUMAN
NC score	0.050264 (rank : 255)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	271	Target Neighborhood Hits	453	Shared Neighborhood Hits	62
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

BCL9_MOUSE
NC score	0.050089 (rank : 256)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	271	Target Neighborhood Hits	770	Shared Neighborhood Hits	90
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

RFX1_HUMAN
NC score	0.049958 (rank : 257)	θ value	1.06291 (rank : 122)
Query Neighborhood Hits	271	Target Neighborhood Hits	256	Shared Neighborhood Hits	37
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

SRBP1_HUMAN
NC score	0.049842 (rank : 258)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	271	Target Neighborhood Hits	225	Shared Neighborhood Hits	17
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

PELP1_HUMAN
NC score	0.049360 (rank : 259)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	271	Target Neighborhood Hits	596	Shared Neighborhood Hits	34
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

DREB_HUMAN
NC score	0.048610 (rank : 260)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	271	Target Neighborhood Hits	450	Shared Neighborhood Hits	25
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

MAML3_HUMAN
NC score	0.046426 (rank : 261)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	271	Target Neighborhood Hits	323	Shared Neighborhood Hits	33
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

RIMB1_MOUSE
NC score	0.046067 (rank : 262)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	271	Target Neighborhood Hits	1376	Shared Neighborhood Hits	95
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RTN4_HUMAN
NC score	0.045294 (rank : 263)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	271	Target Neighborhood Hits	357	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

TENS1_HUMAN
NC score	0.044342 (rank : 264)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	271	Target Neighborhood Hits	400	Shared Neighborhood Hits	48
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CSKI2_HUMAN
NC score	0.042026 (rank : 265)	θ value	1.81305 (rank : 144)
Query Neighborhood Hits	271	Target Neighborhood Hits	747	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI1_HUMAN
NC score	0.041373 (rank : 266)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	271	Target Neighborhood Hits	997	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

RFX1_MOUSE
NC score	0.040524 (rank : 267)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	271	Target Neighborhood Hits	181	Shared Neighborhood Hits	17
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

ANK2_HUMAN
NC score	0.040171 (rank : 268)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	271	Target Neighborhood Hits	1615	Shared Neighborhood Hits	102
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

AFF1_HUMAN
NC score	0.039963 (rank : 269)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	271	Target Neighborhood Hits	506	Shared Neighborhood Hits	43
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

COIA1_HUMAN
NC score	0.039274 (rank : 270)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	271	Target Neighborhood Hits	447	Shared Neighborhood Hits	35
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

MYO1F_MOUSE
NC score	0.038999 (rank : 271)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	271	Target Neighborhood Hits	262	Shared Neighborhood Hits	53
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.038974 (rank : 272)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	271	Target Neighborhood Hits	275	Shared Neighborhood Hits	60
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MNT_MOUSE
NC score	0.038500 (rank : 273)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	271	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ACINU_MOUSE
NC score	0.037855 (rank : 274)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	271	Target Neighborhood Hits	712	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

SFPQ_MOUSE
NC score	0.036994 (rank : 275)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	271	Target Neighborhood Hits	958	Shared Neighborhood Hits	48
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

XRCC1_MOUSE
NC score	0.036728 (rank : 276)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	271	Target Neighborhood Hits	242	Shared Neighborhood Hits	18
SwissProt Accessions	Q60596, Q3THC5, Q5U435, Q7TNQ5	Gene names	Xrcc1, Xrcc-1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

WBS14_HUMAN
NC score	0.035924 (rank : 277)	θ value	2.36792 (rank : 163)
Query Neighborhood Hits	271	Target Neighborhood Hits	273	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

TENS4_MOUSE
NC score	0.034097 (rank : 278)	θ value	8.99809 (rank : 269)
Query Neighborhood Hits	271	Target Neighborhood Hits	225	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

JIP3_HUMAN
NC score	0.034000 (rank : 279)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	271	Target Neighborhood Hits	1039	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

GNDS_MOUSE
NC score	0.032553 (rank : 280)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	271	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

IRX2_HUMAN
NC score	0.031876 (rank : 281)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	271	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BZI1, Q7Z2I7	Gene names	IRX2, IRXA2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-2 (Iroquois homeobox protein 2) (Homeodomain protein IRXA2).

GNDS_HUMAN
NC score	0.031698 (rank : 282)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	271	Target Neighborhood Hits	201	Shared Neighborhood Hits	18
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

T22D4_MOUSE
NC score	0.030596 (rank : 283)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	271	Target Neighborhood Hits	92	Shared Neighborhood Hits	20
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

COFA1_MOUSE
NC score	0.029815 (rank : 284)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	271	Target Neighborhood Hits	305	Shared Neighborhood Hits	26
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

SOX18_HUMAN
NC score	0.029634 (rank : 285)	θ value	1.06291 (rank : 126)
Query Neighborhood Hits	271	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	P35713, Q9NPH8	Gene names	SOX18
Domain Architecture
Description	Transcription factor SOX-18.

RAI1_MOUSE
NC score	0.029402 (rank : 286)	θ value	8.99809 (rank : 264)
Query Neighborhood Hits	271	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

COIA1_MOUSE
NC score	0.029377 (rank : 287)	θ value	1.06291 (rank : 110)
Query Neighborhood Hits	271	Target Neighborhood Hits	481	Shared Neighborhood Hits	34
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

NFAC4_HUMAN
NC score	0.029041 (rank : 288)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	271	Target Neighborhood Hits	165	Shared Neighborhood Hits	18
SwissProt Accessions	Q14934	Gene names	NFATC4, NFAT3
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 4 (NF-ATc4) (NFATc4) (T cell transcription factor NFAT3) (NF-AT3).

TIMD2_MOUSE
NC score	0.029032 (rank : 289)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	271	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R183, Q8VBW0	Gene names	Timd2, Tim2
Domain Architecture	No domain graphic available
Description	T-cell immunoglobulin and mucin domain-containing protein 2 precursor (TIMD-2) (T cell membrane protein 2) (TIM-2).

HCN4_MOUSE
NC score	0.028983 (rank : 290)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	271	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	O70507	Gene names	Hcn4, Bcng3
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Brain cyclic nucleotide-gated channel 3) (BCNG-3).

HCN4_HUMAN
NC score	0.028907 (rank : 291)	θ value	1.81305 (rank : 146)
Query Neighborhood Hits	271	Target Neighborhood Hits	303	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Y3Q4, Q9UMQ7	Gene names	HCN4
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

MELPH_HUMAN
NC score	0.028907 (rank : 292)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	271	Target Neighborhood Hits	145	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MINT_HUMAN
NC score	0.028756 (rank : 293)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	271	Target Neighborhood Hits	1291	Shared Neighborhood Hits	70
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

DMP1_MOUSE
NC score	0.026916 (rank : 294)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	271	Target Neighborhood Hits	498	Shared Neighborhood Hits	21
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

RNF25_HUMAN
NC score	0.026751 (rank : 295)	θ value	8.99809 (rank : 266)
Query Neighborhood Hits	271	Target Neighborhood Hits	163	Shared Neighborhood Hits	19
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

ACK1_HUMAN
NC score	0.026559 (rank : 296)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	271	Target Neighborhood Hits	1140	Shared Neighborhood Hits	78
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

CABL2_HUMAN
NC score	0.026248 (rank : 297)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	271	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

FYN_MOUSE
NC score	0.026064 (rank : 298)	θ value	1.06291 (rank : 118)
Query Neighborhood Hits	271	Target Neighborhood Hits	1073	Shared Neighborhood Hits	68
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SMRC2_HUMAN
NC score	0.025891 (rank : 299)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	271	Target Neighborhood Hits	499	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

FYN_HUMAN
NC score	0.025740 (rank : 300)	θ value	1.06291 (rank : 117)
Query Neighborhood Hits	271	Target Neighborhood Hits	1078	Shared Neighborhood Hits	70
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

NOL3_MOUSE
NC score	0.025727 (rank : 301)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	271	Target Neighborhood Hits	97	Shared Neighborhood Hits	12
SwissProt Accessions	Q9D1X0	Gene names	Nol3
Domain Architecture
Description	Nucleolar protein 3.

SPEG_MOUSE
NC score	0.025637 (rank : 302)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	271	Target Neighborhood Hits	1959	Shared Neighborhood Hits	120
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

IER2_MOUSE
NC score	0.025451 (rank : 303)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	271	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	P17950, Q64251, Q8BME8, Q99M25	Gene names	Ier2
Domain Architecture
Description	Immediate early response gene 2 protein (T-lymphocyte-activated protein) (Cycloheximide-induced gene protein) (CHX1) (Growth factor- inducible immediate early protein) (Proline-rich-induced protein 92) (Pip92).

SPEG_HUMAN
NC score	0.025041 (rank : 304)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	271	Target Neighborhood Hits	1762	Shared Neighborhood Hits	83
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CAC1B_MOUSE
NC score	0.024929 (rank : 305)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	271	Target Neighborhood Hits	351	Shared Neighborhood Hits	39
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

ACK1_MOUSE
NC score	0.024900 (rank : 306)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	271	Target Neighborhood Hits	1080	Shared Neighborhood Hits	72
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

SOS2_HUMAN
NC score	0.024381 (rank : 307)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	271	Target Neighborhood Hits	193	Shared Neighborhood Hits	19
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

JPH2_MOUSE
NC score	0.023881 (rank : 308)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	271	Target Neighborhood Hits	279	Shared Neighborhood Hits	32
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

DGKK_HUMAN
NC score	0.023827 (rank : 309)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	271	Target Neighborhood Hits	378	Shared Neighborhood Hits	29
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

FILA_HUMAN
NC score	0.023266 (rank : 310)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	271	Target Neighborhood Hits	685	Shared Neighborhood Hits	27
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

FBLI1_MOUSE
NC score	0.023249 (rank : 311)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	271	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q71FD7, Q99J35	Gene names	Fblim1, Cal
Domain Architecture	No domain graphic available
Description	Filamin-binding LIM protein 1 (CSX-associated LIM).

AUXI_HUMAN
NC score	0.022923 (rank : 312)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	271	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	O75061, Q32M66, Q4G0K1, Q5T614, Q5T615	Gene names	DNAJC6, KIAA0473
Domain Architecture	No domain graphic available
Description	Putative tyrosine-protein phosphatase auxilin (EC 3.1.3.48) (DnaJ homolog subfamily C member 6).

DMRTC_HUMAN
NC score	0.022581 (rank : 313)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	271	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q5HYR2, Q5HYR0, Q5U5K2, Q8N6L3, Q96SD3	Gene names	DMRTC1
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C1.

ANKS6_MOUSE
NC score	0.022511 (rank : 314)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	22
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

CAC1B_HUMAN
NC score	0.022359 (rank : 315)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	271	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

FGR_HUMAN
NC score	0.022251 (rank : 316)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	271	Target Neighborhood Hits	1067	Shared Neighborhood Hits	67
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GTF2I_HUMAN
NC score	0.022058 (rank : 317)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	15
SwissProt Accessions	P78347, O14743, O15359, O43546, O43588, O43589, Q9BSZ4	Gene names	GTF2I, BAP135, WBSCR6
Domain Architecture
Description	General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BTK-associated protein 135) (BAP-135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosome region 6 protein).

OAZ1_HUMAN
NC score	0.021972 (rank : 318)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	271	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P54368, O43382, Q14989, Q92595, Q9UPL9	Gene names	OAZ1, OAZ
Domain Architecture
Description	Ornithine decarboxylase antizyme (ODC-Az).

LDB3_HUMAN
NC score	0.021792 (rank : 319)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	271	Target Neighborhood Hits	497	Shared Neighborhood Hits	34
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

PDCD7_MOUSE
NC score	0.021448 (rank : 320)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	271	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTY1, Q8R5D9	Gene names	Pdcd7
Domain Architecture	No domain graphic available
Description	Programmed cell death protein 7 (ES18).

SF3B4_HUMAN
NC score	0.021389 (rank : 321)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	271	Target Neighborhood Hits	445	Shared Neighborhood Hits	26
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

ERF_HUMAN
NC score	0.021218 (rank : 322)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	271	Target Neighborhood Hits	162	Shared Neighborhood Hits	16
SwissProt Accessions	P50548, Q9UPI7	Gene names	ERF
Domain Architecture
Description	ETS domain-containing transcription factor ERF (Ets2 repressor factor).

TCAL5_HUMAN
NC score	0.021090 (rank : 323)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	271	Target Neighborhood Hits	806	Shared Neighborhood Hits	33
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TXK_MOUSE
NC score	0.020150 (rank : 324)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	271	Target Neighborhood Hits	980	Shared Neighborhood Hits	59
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

PGCA_HUMAN
NC score	0.020038 (rank : 325)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	271	Target Neighborhood Hits	821	Shared Neighborhood Hits	38
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

AP2A1_HUMAN
NC score	0.019966 (rank : 326)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	271	Target Neighborhood Hits	56	Shared Neighborhood Hits	6
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

TBCD1_MOUSE
NC score	0.019748 (rank : 327)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	271	Target Neighborhood Hits	241	Shared Neighborhood Hits	14
SwissProt Accessions	Q60949, Q80TJ9, Q923F8	Gene names	Tbc1d1, Kiaa1108, Tbc1
Domain Architecture
Description	TBC1 domain family member 1.

ATBF1_MOUSE
NC score	0.019581 (rank : 328)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	271	Target Neighborhood Hits	1841	Shared Neighborhood Hits	63
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

AP2A1_MOUSE
NC score	0.019174 (rank : 329)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	271	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	P17426	Gene names	Ap2a1, Adtaa, Clapa1
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

TXND2_MOUSE
NC score	0.018973 (rank : 330)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	271	Target Neighborhood Hits	828	Shared Neighborhood Hits	31
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

CELR2_HUMAN
NC score	0.018750 (rank : 331)	θ value	0.0193708 (rank : 29)
Query Neighborhood Hits	271	Target Neighborhood Hits	657	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

ZN516_MOUSE
NC score	0.018457 (rank : 332)	θ value	1.06291 (rank : 131)
Query Neighborhood Hits	271	Target Neighborhood Hits	1197	Shared Neighborhood Hits	84
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CELR2_MOUSE
NC score	0.017421 (rank : 333)	θ value	0.0736092 (rank : 42)
Query Neighborhood Hits	271	Target Neighborhood Hits	584	Shared Neighborhood Hits	8
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

SYTL5_HUMAN
NC score	0.017366 (rank : 334)	θ value	1.06291 (rank : 128)
Query Neighborhood Hits	271	Target Neighborhood Hits	237	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDW5	Gene names	SYTL5, SLP5
Domain Architecture
Description	Synaptotagmin-like protein 5.

GAK_HUMAN
NC score	0.016948 (rank : 335)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	271	Target Neighborhood Hits	1028	Shared Neighborhood Hits	51
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

LCK_HUMAN
NC score	0.016935 (rank : 336)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	271	Target Neighborhood Hits	987	Shared Neighborhood Hits	57
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
NC score	0.016836 (rank : 337)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	271	Target Neighborhood Hits	981	Shared Neighborhood Hits	57
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

HNRPK_HUMAN
NC score	0.016721 (rank : 338)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	271	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P61978, Q07244, Q15671, Q60577, Q922Y7, Q96J62	Gene names	HNRPK, HNRNPK
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP).

HNRPK_MOUSE
NC score	0.016721 (rank : 339)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	271	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	P61979, Q07244, Q15671, Q60577, Q8BGQ8, Q922Y7, Q96J62	Gene names	Hnrpk, Hnrnpk
Domain Architecture
Description	Heterogeneous nuclear ribonucleoprotein K.

SPAST_HUMAN
NC score	0.016081 (rank : 340)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	271	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

POGZ_MOUSE
NC score	0.016075 (rank : 341)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	271	Target Neighborhood Hits	765	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BZH4, Q4VA94, Q80TZ8, Q8C0K1, Q8K294	Gene names	Pogz, Kiaa0461
Domain Architecture
Description	Pogo transposable element with ZNF domain.

EI2BE_HUMAN
NC score	0.015649 (rank : 342)	θ value	8.99809 (rank : 245)
Query Neighborhood Hits	271	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q13144, Q96D04	Gene names	EIF2B5, EIF2BE
Domain Architecture
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

CT075_HUMAN
NC score	0.015637 (rank : 343)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	271	Target Neighborhood Hits	387	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

CO9A3_HUMAN
NC score	0.015042 (rank : 344)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	271	Target Neighborhood Hits	361	Shared Neighborhood Hits	26
SwissProt Accessions	Q14050, Q13681, Q9H4G9, Q9UPE2	Gene names	COL9A3
Domain Architecture	No domain graphic available
Description	Collagen alpha-3(IX) chain precursor.

SEN34_MOUSE
NC score	0.014752 (rank : 345)	θ value	8.99809 (rank : 267)
Query Neighborhood Hits	271	Target Neighborhood Hits	158	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

TXK_HUMAN
NC score	0.014216 (rank : 346)	θ value	8.99809 (rank : 270)
Query Neighborhood Hits	271	Target Neighborhood Hits	971	Shared Neighborhood Hits	49
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

HXA3_MOUSE
NC score	0.013431 (rank : 347)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	271	Target Neighborhood Hits	558	Shared Neighborhood Hits	37
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

ULK1_MOUSE
NC score	0.012981 (rank : 348)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	271	Target Neighborhood Hits	1214	Shared Neighborhood Hits	88
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ESPL1_HUMAN
NC score	0.012780 (rank : 349)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	271	Target Neighborhood Hits	95	Shared Neighborhood Hits	11
SwissProt Accessions	Q14674	Gene names	ESPL1, ESP1, KIAA0165
Domain Architecture
Description	Separin (EC 3.4.22.49) (Separase) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein).

ZN687_MOUSE
NC score	0.012550 (rank : 350)	θ value	1.81305 (rank : 152)
Query Neighborhood Hits	271	Target Neighborhood Hits	913	Shared Neighborhood Hits	46
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

AMOL1_HUMAN
NC score	0.012291 (rank : 351)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	271	Target Neighborhood Hits	435	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

FOXJ2_MOUSE
NC score	0.012029 (rank : 352)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	271	Target Neighborhood Hits	151	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ES18	Gene names	Foxj2, Fhx
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

CEND3_HUMAN
NC score	0.011830 (rank : 353)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	271	Target Neighborhood Hits	275	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

MAST3_HUMAN
NC score	0.011676 (rank : 354)	θ value	1.06291 (rank : 120)
Query Neighborhood Hits	271	Target Neighborhood Hits	1128	Shared Neighborhood Hits	47
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PTN4_HUMAN
NC score	0.011399 (rank : 355)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	271	Target Neighborhood Hits	303	Shared Neighborhood Hits	11
SwissProt Accessions	P29074	Gene names	PTPN4
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (PTPase-MEG1) (MEG).

MYST4_HUMAN
NC score	0.011230 (rank : 356)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	271	Target Neighborhood Hits	671	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

CAC1H_MOUSE
NC score	0.010890 (rank : 357)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	271	Target Neighborhood Hits	230	Shared Neighborhood Hits	23
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

GBX1_MOUSE
NC score	0.010871 (rank : 358)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	271	Target Neighborhood Hits	350	Shared Neighborhood Hits	10
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

SIGL5_MOUSE
NC score	0.010829 (rank : 359)	θ value	1.81305 (rank : 150)
Query Neighborhood Hits	271	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

E2F1_HUMAN
NC score	0.010691 (rank : 360)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	271	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q01094, Q13143, Q92768	Gene names	E2F1, RBBP3
Domain Architecture
Description	Transcription factor E2F1 (E2F-1) (Retinoblastoma-binding protein 3) (RBBP-3) (PRB-binding protein E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1).

SYGP1_HUMAN
NC score	0.010443 (rank : 361)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	271	Target Neighborhood Hits	589	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PV0, Q8TCS2, Q9UGE2	Gene names	SYNGAP1, KIAA1938
Domain Architecture
Description	Ras GTPase-activating protein SynGAP (Synaptic Ras-GTPase-activating protein 1) (Synaptic Ras-GAP 1) (Neuronal RasGAP).

RECQ4_HUMAN
NC score	0.010229 (rank : 362)	θ value	8.99809 (rank : 265)
Query Neighborhood Hits	271	Target Neighborhood Hits	177	Shared Neighborhood Hits	16
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

FOXJ2_HUMAN
NC score	0.010130 (rank : 363)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	271	Target Neighborhood Hits	239	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P0K8, Q96PS9, Q9NSN5	Gene names	FOXJ2, FHX
Domain Architecture
Description	Forkhead box protein J2 (Fork head homologous X).

NPAS1_MOUSE
NC score	0.009932 (rank : 364)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	271	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

INP4A_HUMAN
NC score	0.009594 (rank : 365)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	271	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96PE3, O15326, Q13187, Q53TD8, Q8TC02	Gene names	INPP4A
Domain Architecture	No domain graphic available
Description	Type I inositol-3,4-bisphosphate 4-phosphatase (EC 3.1.3.66) (Inositol polyphosphate 4-phosphatase type I).

LAP2_HUMAN
NC score	0.009300 (rank : 366)	θ value	1.06291 (rank : 119)
Query Neighborhood Hits	271	Target Neighborhood Hits	499	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RT1, Q86W38, Q9NR18, Q9NW48, Q9ULJ5	Gene names	ERBB2IP, ERBIN, KIAA1225, LAP2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

GBX1_HUMAN
NC score	0.008571 (rank : 367)	θ value	1.81305 (rank : 145)
Query Neighborhood Hits	271	Target Neighborhood Hits	334	Shared Neighborhood Hits	9
SwissProt Accessions	Q14549	Gene names	GBX1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

MICA1_MOUSE
NC score	0.008486 (rank : 368)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	271	Target Neighborhood Hits	400	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

CBX6_MOUSE
NC score	0.007504 (rank : 369)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	271	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

BRSK1_HUMAN
NC score	0.007406 (rank : 370)	θ value	1.81305 (rank : 142)
Query Neighborhood Hits	271	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

FKBP4_HUMAN
NC score	0.007387 (rank : 371)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	271	Target Neighborhood Hits	114	Shared Neighborhood Hits	5
SwissProt Accessions	Q02790, Q9UCP1, Q9UCV7	Gene names	FKBP4
Domain Architecture
Description	FK506-binding protein 4 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (p59 protein) (HSP-binding immunophilin) (HBI) (FKBP52 protein) (52 kDa FK506-binding protein) (FKBP59).

KBTBB_HUMAN
NC score	0.007100 (rank : 372)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	271	Target Neighborhood Hits	195	Shared Neighborhood Hits	7
SwissProt Accessions	O94819	Gene names	KBTBD11, KIAA0711, KLHDC7C
Domain Architecture	No domain graphic available
Description	Kelch repeat and BTB domain-containing protein 11 (Kelch domain- containing protein 7B).

PSD4_MOUSE
NC score	0.006699 (rank : 373)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	271	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BLR5, Q3TE33, Q3TQF5, Q3UD59, Q3UFH9, Q80V44	Gene names	Psd4
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4).

PO2F2_HUMAN
NC score	0.006264 (rank : 374)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	271	Target Neighborhood Hits	379	Shared Neighborhood Hits	21
SwissProt Accessions	P09086, Q16648, Q9BRS4	Gene names	POU2F2, OCT2, OTF2
Domain Architecture
Description	POU domain, class 2, transcription factor 2 (Octamer-binding transcription factor 2) (Oct-2) (OTF-2) (Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2).

FOG1_HUMAN
NC score	0.006215 (rank : 375)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	271	Target Neighborhood Hits	981	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

MINK1_MOUSE
NC score	0.005645 (rank : 376)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	271	Target Neighborhood Hits	1451	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

BCL6B_HUMAN
NC score	0.003460 (rank : 377)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	271	Target Neighborhood Hits	855	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N143, Q6PCB4	Gene names	BCL6B, BAZF, ZNF62
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 6 member B protein (Bcl6-associated zinc finger protein) (Zinc finger protein 62).

DDX31_HUMAN
NC score	0.002843 (rank : 378)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	271	Target Neighborhood Hits	132	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

GLT11_HUMAN
NC score	0.002044 (rank : 379)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	271	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCW6, Q6PCD1, Q9H6C2, Q9H6Z5, Q9UDR8	Gene names	GALNT11
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase 11 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase 11) (UDP- GalNAc:polypeptide N-acetylgalactosaminyltransferase 11) (Polypeptide GalNAc transferase 11) (GalNAc-T11) (pp-GaNTase 11).

KLF16_HUMAN
NC score	0.000485 (rank : 380)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	271	Target Neighborhood Hits	737	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BXK1	Gene names	KLF16, BTEB4, NSLP2
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 16 (Transcription factor BTEB4) (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor NSLP2).

ZBT16_HUMAN
NC score	-0.001336 (rank : 381)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	271	Target Neighborhood Hits	1010	Shared Neighborhood Hits	40
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).