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Network neighborhood for query Sequence : APBB2_MOUSE

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APBB2_MOUSE
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APBB2_HUMAN
θ value	0 (rank : 1)	NC score	0.987777 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB1_MOUSE
θ value	1.19589e-169 (rank : 3)	NC score	0.954673 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_HUMAN
θ value	5.02443e-168 (rank : 4)	NC score	0.956712 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	62	Shared Neighborhood Hits	26
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB3_HUMAN
θ value	1.48926e-103 (rank : 5)	NC score	0.940212 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	2.80862e-102 (rank : 6)	NC score	0.940102 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

WWP2_MOUSE
θ value	4.1701e-05 (rank : 7)	NC score	0.182589 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP1_HUMAN
θ value	0.00035302 (rank : 8)	NC score	0.169774 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	262	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_MOUSE
θ value	0.00175202 (rank : 9)	NC score	0.150578 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	127	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

MDC1_MOUSE
θ value	0.00228821 (rank : 10)	NC score	0.049215 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	998	Shared Neighborhood Hits	27
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NEDD4_HUMAN
θ value	0.00509761 (rank : 11)	NC score	0.150765 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	0.00665767 (rank : 12)	NC score	0.147991 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	212	Shared Neighborhood Hits	27
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

JIP1_HUMAN
θ value	0.00869519 (rank : 13)	NC score	0.115746 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	271	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

ITCH_HUMAN
θ value	0.0113563 (rank : 14)	NC score	0.146833 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NED4L_HUMAN
θ value	0.0113563 (rank : 15)	NC score	0.145549 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	28
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

WWP1_MOUSE
θ value	0.0113563 (rank : 16)	NC score	0.161005 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.166925 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

NED4L_MOUSE
θ value	0.0330416 (rank : 18)	NC score	0.143461 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NACAM_MOUSE
θ value	0.0431538 (rank : 19)	NC score	0.046852 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	1866	Shared Neighborhood Hits	47
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MAP1A_HUMAN
θ value	0.0563607 (rank : 20)	NC score	0.032992 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	1626	Shared Neighborhood Hits	27
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ARH_HUMAN
θ value	0.0736092 (rank : 21)	NC score	0.122806 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

SETD2_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.141049 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	412	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SMUF2_HUMAN
θ value	0.0736092 (rank : 23)	NC score	0.147451 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ARH_MOUSE
θ value	0.0961366 (rank : 24)	NC score	0.122247 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

JIP1_MOUSE
θ value	0.0961366 (rank : 25)	NC score	0.099885 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

MLL2_HUMAN
θ value	0.125558 (rank : 26)	NC score	0.030458 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

GAS7_HUMAN
θ value	0.163984 (rank : 27)	NC score	0.116324 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

CAPON_HUMAN
θ value	0.279714 (rank : 28)	NC score	0.112257 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

NUMBL_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.081252 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUMBL_MOUSE
θ value	0.279714 (rank : 30)	NC score	0.090044 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	147	Shared Neighborhood Hits	16
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

SOX9_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.021122 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

LIPS_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.035345 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

NUCL_HUMAN
θ value	0.47712 (rank : 33)	NC score	0.026175 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	415	Shared Neighborhood Hits	8
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

PCLO_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.045659 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PTPRG_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.010633 (rank : 104)
Query Neighborhood Hits	88	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

CAPON_MOUSE
θ value	0.62314 (rank : 36)	NC score	0.103163 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

PIN1_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.158335 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	59	Shared Neighborhood Hits	22
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.176804 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	60	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

SMUF1_MOUSE
θ value	0.62314 (rank : 39)	NC score	0.118863 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

GAS7_MOUSE
θ value	0.813845 (rank : 40)	NC score	0.103266 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

ZCHC8_MOUSE
θ value	0.813845 (rank : 41)	NC score	0.053020 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

KLH14_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.008111 (rank : 106)
Query Neighborhood Hits	88	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2G3	Gene names	KLHL14, KIAA1384
Domain Architecture	No domain graphic available
Description	Kelch-like protein 14.

PCLO_MOUSE
θ value	1.06291 (rank : 43)	NC score	0.040855 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	2275	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ZEP2_HUMAN
θ value	1.06291 (rank : 44)	NC score	0.007075 (rank : 111)
Query Neighborhood Hits	88	Target Neighborhood Hits	937	Shared Neighborhood Hits	16
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

NOLC1_HUMAN
θ value	1.38821 (rank : 45)	NC score	0.032427 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	452	Shared Neighborhood Hits	15
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PINL_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.179114 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

CA106_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.020347 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CI079_HUMAN
θ value	1.81305 (rank : 48)	NC score	0.053841 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

MAST4_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.005172 (rank : 116)
Query Neighborhood Hits	88	Target Neighborhood Hits	1804	Shared Neighborhood Hits	29
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

NUMB_HUMAN
θ value	1.81305 (rank : 50)	NC score	0.097242 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

NUMB_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.098448 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

STON2_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.031587 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

ANKS6_MOUSE
θ value	2.36792 (rank : 53)	NC score	0.007169 (rank : 110)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	7
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

PELP1_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.023791 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	709	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

TEX14_HUMAN
θ value	2.36792 (rank : 55)	NC score	0.007854 (rank : 107)
Query Neighborhood Hits	88	Target Neighborhood Hits	1103	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

YLPM1_HUMAN
θ value	2.36792 (rank : 56)	NC score	0.029833 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	670	Shared Neighborhood Hits	25
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZN451_MOUSE
θ value	2.36792 (rank : 57)	NC score	0.010142 (rank : 105)
Query Neighborhood Hits	88	Target Neighborhood Hits	643	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0P7	Gene names	Znf451, Zfp451
Domain Architecture	No domain graphic available
Description	Zinc finger protein 451.

BSN_HUMAN
θ value	3.0926 (rank : 58)	NC score	0.028640 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	1537	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ACINU_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.018468 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	828	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

CD44_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.023743 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P16070, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q96J24	Gene names	CD44, LHR
Domain Architecture
Description	CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I) (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican) (CDw44).

GP125_MOUSE
θ value	4.03905 (rank : 61)	NC score	0.004844 (rank : 117)
Query Neighborhood Hits	88	Target Neighborhood Hits	329	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

IQGA3_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.011148 (rank : 102)
Query Neighborhood Hits	88	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

PAWR_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.018811 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	252	Shared Neighborhood Hits	2
SwissProt Accessions	Q96IZ0, O75796, Q6FHY9, Q8N700	Gene names	PAWR, PAR4
Domain Architecture	No domain graphic available
Description	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4).

THYG_MOUSE
θ value	4.03905 (rank : 64)	NC score	0.011557 (rank : 101)
Query Neighborhood Hits	88	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

TP53B_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.027217 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	413	Shared Neighborhood Hits	19
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

BASP_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.023929 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	321	Shared Neighborhood Hits	11
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

CD2L7_HUMAN
θ value	5.27518 (rank : 67)	NC score	0.001704 (rank : 119)
Query Neighborhood Hits	88	Target Neighborhood Hits	1275	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CS007_MOUSE
θ value	5.27518 (rank : 68)	NC score	0.016898 (rank : 96)
Query Neighborhood Hits	88	Target Neighborhood Hits	464	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

GP1BA_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.013229 (rank : 98)
Query Neighborhood Hits	88	Target Neighborhood Hits	407	Shared Neighborhood Hits	10
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

MYOM1_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.005847 (rank : 114)
Query Neighborhood Hits	88	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

ZF106_MOUSE
θ value	5.27518 (rank : 71)	NC score	0.007815 (rank : 108)
Query Neighborhood Hits	88	Target Neighborhood Hits	472	Shared Neighborhood Hits	7
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

ZN507_HUMAN
θ value	5.27518 (rank : 72)	NC score	0.003073 (rank : 118)
Query Neighborhood Hits	88	Target Neighborhood Hits	739	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

CASZ1_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.011759 (rank : 99)
Query Neighborhood Hits	88	Target Neighborhood Hits	473	Shared Neighborhood Hits	9
SwissProt Accessions	Q86V15, Q5T9S1, Q8WX49, Q8WX50, Q9BT16, Q9NXC6	Gene names	CASZ1, CST, ZNF693
Domain Architecture	No domain graphic available
Description	Castor homolog 1 zinc finger protein (Castor-related protein) (Zinc finger protein 693).

CSTF2_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.005714 (rank : 115)
Query Neighborhood Hits	88	Target Neighborhood Hits	296	Shared Neighborhood Hits	3
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

RIMS2_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.023587 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	342	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

SYNJ1_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.017763 (rank : 95)
Query Neighborhood Hits	88	Target Neighborhood Hits	516	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCOF_MOUSE
θ value	6.88961 (rank : 77)	NC score	0.024822 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	471	Shared Neighborhood Hits	16
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

EME1_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.011108 (rank : 103)
Query Neighborhood Hits	88	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJW7	Gene names	Eme1
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-).

ENL_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.018569 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

GNB1L_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.013421 (rank : 97)
Query Neighborhood Hits	88	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

JPH1_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.006752 (rank : 112)
Query Neighborhood Hits	88	Target Neighborhood Hits	120	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

MAST3_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.000970 (rank : 121)
Query Neighborhood Hits	88	Target Neighborhood Hits	1128	Shared Neighborhood Hits	17
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PARM1_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.022693 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

PTPRZ_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.007450 (rank : 109)
Query Neighborhood Hits	88	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

SOX9_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.011745 (rank : 100)
Query Neighborhood Hits	88	Target Neighborhood Hits	188	Shared Neighborhood Hits	6
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

SRRM2_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.020323 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	1296	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TIF1G_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.006675 (rank : 113)
Query Neighborhood Hits	88	Target Neighborhood Hits	410	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

TTBK2_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.001139 (rank : 120)
Query Neighborhood Hits	88	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

BAG3_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.056511 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

EDD1_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.059588 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.059537 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD1_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.055357 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	371	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.087164 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.087814 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.060094 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.061147 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.056604 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.057424 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.070636 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	62	Shared Neighborhood Hits	12
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.072524 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.090822 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	443	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.099533 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	406	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.091944 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.091876 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

MAGI1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.056048 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	388	Shared Neighborhood Hits	26
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.054686 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	403	Shared Neighborhood Hits	27
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

SAV1_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.081765 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.077971 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SMUF1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.107067 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

TRIPC_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.079614 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	319	Shared Neighborhood Hits	20
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.084922 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.083857 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.083728 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	51	Shared Neighborhood Hits	12
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.083440 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWC1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.056252 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.055853 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	290	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.058074 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	115	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.057548 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	118	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWTR1_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.059350 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.082890 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	173	Shared Neighborhood Hits	28
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.095418 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	24
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

APBB2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB2_HUMAN
NC score	0.987777 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	54
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB1_HUMAN
NC score	0.956712 (rank : 3)	θ value	5.02443e-168 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	62	Shared Neighborhood Hits	26
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.954673 (rank : 4)	θ value	1.19589e-169 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB3_HUMAN
NC score	0.940212 (rank : 5)	θ value	1.48926e-103 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
NC score	0.940102 (rank : 6)	θ value	2.80862e-102 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

WWP2_MOUSE
NC score	0.182589 (rank : 7)	θ value	4.1701e-05 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

PINL_HUMAN
NC score	0.179114 (rank : 8)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PIN1_MOUSE
NC score	0.176804 (rank : 9)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	60	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWP1_HUMAN
NC score	0.169774 (rank : 10)	θ value	0.00035302 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	262	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP2_HUMAN
NC score	0.166925 (rank : 11)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_MOUSE
NC score	0.161005 (rank : 12)	θ value	0.0113563 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	138	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

PIN1_HUMAN
NC score	0.158335 (rank : 13)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	59	Shared Neighborhood Hits	22
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

NEDD4_HUMAN
NC score	0.150765 (rank : 14)	θ value	0.00509761 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	214	Shared Neighborhood Hits	27
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

ITCH_MOUSE
NC score	0.150578 (rank : 15)	θ value	0.00175202 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	127	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

NEDD4_MOUSE
NC score	0.147991 (rank : 16)	θ value	0.00665767 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	212	Shared Neighborhood Hits	27
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF2_HUMAN
NC score	0.147451 (rank : 17)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	142	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ITCH_HUMAN
NC score	0.146833 (rank : 18)	θ value	0.0113563 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	162	Shared Neighborhood Hits	27
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NED4L_HUMAN
NC score	0.145549 (rank : 19)	θ value	0.0113563 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	28
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.143461 (rank : 20)	θ value	0.0330416 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	231	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SETD2_HUMAN
NC score	0.141049 (rank : 21)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	412	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

ARH_HUMAN
NC score	0.122806 (rank : 22)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q5SW96, Q6TQS9, Q8N2Y0, Q9UFI9	Gene names	LDLRAP1, ARH
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein).

ARH_MOUSE
NC score	0.122247 (rank : 23)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	32	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C142, Q6NWV6, Q8VDQ0	Gene names	Ldlrap1, Arh
Domain Architecture	No domain graphic available
Description	Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).

SMUF1_MOUSE
NC score	0.118863 (rank : 24)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	142	Shared Neighborhood Hits	22
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

GAS7_HUMAN
NC score	0.116324 (rank : 25)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

JIP1_HUMAN
NC score	0.115746 (rank : 26)	θ value	0.00869519 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	271	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

CAPON_HUMAN
NC score	0.112257 (rank : 27)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	35	Shared Neighborhood Hits	14
SwissProt Accessions	O75052, O43564	Gene names	NOS1AP, CAPON, KIAA0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

SMUF1_HUMAN
NC score	0.107067 (rank : 28)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	88	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

GAS7_MOUSE
NC score	0.103266 (rank : 29)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	23
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

CAPON_MOUSE
NC score	0.103163 (rank : 30)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D3A8, Q80TZ6	Gene names	Nos1ap, Capon, Kiaa0464
Domain Architecture	No domain graphic available
Description	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C--terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein).

JIP1_MOUSE
NC score	0.099885 (rank : 31)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

HUWE1_MOUSE
NC score	0.099533 (rank : 32)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	88	Target Neighborhood Hits	406	Shared Neighborhood Hits	23
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NUMB_MOUSE
NC score	0.098448 (rank : 33)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

NUMB_HUMAN
NC score	0.097242 (rank : 34)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	112	Shared Neighborhood Hits	18
SwissProt Accessions	P49757, Q6NUQ7, Q86SY1, Q8WW73, Q9UBG1, Q9UEQ4, Q9UKE8, Q9UKE9, Q9UKF0, Q9UQJ4	Gene names	NUMB
Domain Architecture
Description	Protein numb homolog (h-Numb) (Protein S171).

YAP1_MOUSE
NC score	0.095418 (rank : 35)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	24
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

K0317_HUMAN
NC score	0.091944 (rank : 36)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	88	Target Neighborhood Hits	46	Shared Neighborhood Hits	12
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.091876 (rank : 37)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	88	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_HUMAN
NC score	0.090822 (rank : 38)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	88	Target Neighborhood Hits	443	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

NUMBL_MOUSE
NC score	0.090044 (rank : 39)	θ value	0.279714 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	147	Shared Neighborhood Hits	16
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

HECD2_MOUSE
NC score	0.087814 (rank : 40)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.087164 (rank : 41)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	41	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.084922 (rank : 42)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.083857 (rank : 43)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
NC score	0.083728 (rank : 44)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	88	Target Neighborhood Hits	51	Shared Neighborhood Hits	12
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.083440 (rank : 45)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

YAP1_HUMAN
NC score	0.082890 (rank : 46)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	88	Target Neighborhood Hits	173	Shared Neighborhood Hits	28
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.081765 (rank : 47)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	88	Target Neighborhood Hits	51	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

NUMBL_HUMAN
NC score	0.081252 (rank : 48)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	394	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

TRIPC_HUMAN
NC score	0.079614 (rank : 49)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	88	Target Neighborhood Hits	319	Shared Neighborhood Hits	20
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

SAV1_MOUSE
NC score	0.077971 (rank : 50)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	88	Target Neighborhood Hits	48	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

HERC5_HUMAN
NC score	0.072524 (rank : 51)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	88	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.070636 (rank : 52)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	88	Target Neighborhood Hits	62	Shared Neighborhood Hits	12
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.061147 (rank : 53)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	88	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.060094 (rank : 54)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	88	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_HUMAN
NC score	0.059588 (rank : 55)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
NC score	0.059537 (rank : 56)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

WWTR1_HUMAN
NC score	0.059350 (rank : 57)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	88	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWOX_HUMAN
NC score	0.058074 (rank : 58)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	88	Target Neighborhood Hits	115	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.057548 (rank : 59)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	88	Target Neighborhood Hits	118	Shared Neighborhood Hits	19
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

HERC2_MOUSE
NC score	0.057424 (rank : 60)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	88	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.056604 (rank : 61)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	88	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

BAG3_HUMAN
NC score	0.056511 (rank : 62)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	25
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

WWC1_HUMAN
NC score	0.056252 (rank : 63)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	88	Target Neighborhood Hits	290	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

MAGI1_HUMAN
NC score	0.056048 (rank : 64)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	88	Target Neighborhood Hits	388	Shared Neighborhood Hits	26
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

WWC1_MOUSE
NC score	0.055853 (rank : 65)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	88	Target Neighborhood Hits	290	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

HECD1_HUMAN
NC score	0.055357 (rank : 66)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	371	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

MAGI1_MOUSE
NC score	0.054686 (rank : 67)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	88	Target Neighborhood Hits	403	Shared Neighborhood Hits	27
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

CI079_HUMAN
NC score	0.053841 (rank : 68)	θ value	1.81305 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	16
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

ZCHC8_MOUSE
NC score	0.053020 (rank : 69)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	134	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CYA6, Q3TK71, Q8CCB7, Q91WQ1	Gene names	Zcchc8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

MDC1_MOUSE
NC score	0.049215 (rank : 70)	θ value	0.00228821 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	998	Shared Neighborhood Hits	27
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NACAM_MOUSE
NC score	0.046852 (rank : 71)	θ value	0.0431538 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	1866	Shared Neighborhood Hits	47
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PCLO_HUMAN
NC score	0.045659 (rank : 72)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
NC score	0.040855 (rank : 73)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	2275	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

LIPS_HUMAN
NC score	0.035345 (rank : 74)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

MAP1A_HUMAN
NC score	0.032992 (rank : 75)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	1626	Shared Neighborhood Hits	27
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NOLC1_HUMAN
NC score	0.032427 (rank : 76)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	452	Shared Neighborhood Hits	15
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

STON2_MOUSE
NC score	0.031587 (rank : 77)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	75	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

MLL2_HUMAN
NC score	0.030458 (rank : 78)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

YLPM1_HUMAN
NC score	0.029833 (rank : 79)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	670	Shared Neighborhood Hits	25
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

BSN_HUMAN
NC score	0.028640 (rank : 80)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	1537	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

TP53B_HUMAN
NC score	0.027217 (rank : 81)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	413	Shared Neighborhood Hits	19
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

NUCL_HUMAN
NC score	0.026175 (rank : 82)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	415	Shared Neighborhood Hits	8
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

TCOF_MOUSE
NC score	0.024822 (rank : 83)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	471	Shared Neighborhood Hits	16
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

BASP_HUMAN
NC score	0.023929 (rank : 84)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	321	Shared Neighborhood Hits	11
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

PELP1_MOUSE
NC score	0.023791 (rank : 85)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	709	Shared Neighborhood Hits	21
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

CD44_HUMAN
NC score	0.023743 (rank : 86)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P16070, P22511, Q04858, Q13419, Q13957, Q13958, Q13959, Q13960, Q13961, Q13967, Q13968, Q13980, Q15861, Q16064, Q16065, Q16066, Q16208, Q16522, Q96J24	Gene names	CD44, LHR
Domain Architecture
Description	CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I) (Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (Hermes antigen) (Hyaluronate receptor) (Heparan sulfate proteoglycan) (Epican) (CDw44).

RIMS2_HUMAN
NC score	0.023587 (rank : 87)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	342	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

PARM1_MOUSE
NC score	0.022693 (rank : 88)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	140	Shared Neighborhood Hits	9
SwissProt Accessions	Q923D3, Q3TTV0, Q3UFU4	Gene names
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

SOX9_HUMAN
NC score	0.021122 (rank : 89)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

CA106_MOUSE
NC score	0.020347 (rank : 90)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	89	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

SRRM2_HUMAN
NC score	0.020323 (rank : 91)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	1296	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

PAWR_HUMAN
NC score	0.018811 (rank : 92)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	252	Shared Neighborhood Hits	2
SwissProt Accessions	Q96IZ0, O75796, Q6FHY9, Q8N700	Gene names	PAWR, PAR4
Domain Architecture	No domain graphic available
Description	PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4).

ENL_HUMAN
NC score	0.018569 (rank : 93)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	305	Shared Neighborhood Hits	13
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

ACINU_HUMAN
NC score	0.018468 (rank : 94)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	828	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

SYNJ1_MOUSE
NC score	0.017763 (rank : 95)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	516	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CS007_MOUSE
NC score	0.016898 (rank : 96)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	464	Shared Neighborhood Hits	14
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

GNB1L_HUMAN
NC score	0.013421 (rank : 97)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYB4, Q9H2S2, Q9H4M4	Gene names	GNB1L, GY2, KIAA1645, WDR14
Domain Architecture
Description	Guanine nucleotide-binding protein subunit beta-like protein 1 (G protein subunit beta-like protein 1) (WD40 repeat-containing protein deleted in VCFS) (Protein WDVCF) (DGCRK3).

GP1BA_HUMAN
NC score	0.013229 (rank : 98)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	407	Shared Neighborhood Hits	10
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

CASZ1_HUMAN
NC score	0.011759 (rank : 99)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	473	Shared Neighborhood Hits	9
SwissProt Accessions	Q86V15, Q5T9S1, Q8WX49, Q8WX50, Q9BT16, Q9NXC6	Gene names	CASZ1, CST, ZNF693
Domain Architecture	No domain graphic available
Description	Castor homolog 1 zinc finger protein (Castor-related protein) (Zinc finger protein 693).

SOX9_MOUSE
NC score	0.011745 (rank : 100)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	188	Shared Neighborhood Hits	6
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

THYG_MOUSE
NC score	0.011557 (rank : 101)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

IQGA3_HUMAN
NC score	0.011148 (rank : 102)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

EME1_MOUSE
NC score	0.011108 (rank : 103)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BJW7	Gene names	Eme1
Domain Architecture	No domain graphic available
Description	Crossover junction endonuclease EME1 (EC 3.1.22.-).

PTPRG_HUMAN
NC score	0.010633 (rank : 104)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	231	Shared Neighborhood Hits	9
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

ZN451_MOUSE
NC score	0.010142 (rank : 105)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	643	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C0P7	Gene names	Znf451, Zfp451
Domain Architecture	No domain graphic available
Description	Zinc finger protein 451.

KLH14_HUMAN
NC score	0.008111 (rank : 106)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2G3	Gene names	KLHL14, KIAA1384
Domain Architecture	No domain graphic available
Description	Kelch-like protein 14.

TEX14_HUMAN
NC score	0.007854 (rank : 107)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	1103	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ZF106_MOUSE
NC score	0.007815 (rank : 108)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	472	Shared Neighborhood Hits	7
SwissProt Accessions	O88466, O55185, O88465, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3	Gene names	Zfp106, H3a, Sh3bp3, Sirm, Znf474
Domain Architecture	No domain graphic available
Description	Zinc finger protein 106 (Zfp-106) (Zinc finger protein 474) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant).

PTPRZ_HUMAN
NC score	0.007450 (rank : 109)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	255	Shared Neighborhood Hits	5
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

ANKS6_MOUSE
NC score	0.007169 (rank : 110)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	7
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ZEP2_HUMAN
NC score	0.007075 (rank : 111)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	937	Shared Neighborhood Hits	16
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

JPH1_MOUSE
NC score	0.006752 (rank : 112)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	120	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

TIF1G_HUMAN
NC score	0.006675 (rank : 113)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	410	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN9, O95855, Q9C017, Q9UJ79	Gene names	TRIM33, KIAA1113, RFG7, TIF1G
Domain Architecture
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33) (RET-fused gene 7 protein) (Rfg7 protein).

MYOM1_MOUSE
NC score	0.005847 (rank : 114)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

CSTF2_HUMAN
NC score	0.005714 (rank : 115)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	296	Shared Neighborhood Hits	3
SwissProt Accessions	P33240, Q5H951, Q6LA74, Q8N502	Gene names	CSTF2
Domain Architecture
Description	Cleavage stimulation factor 64 kDa subunit (CSTF 64 kDa subunit) (CF-1 64 kDa subunit) (CstF-64).

MAST4_HUMAN
NC score	0.005172 (rank : 116)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	1804	Shared Neighborhood Hits	29
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

GP125_MOUSE
NC score	0.004844 (rank : 117)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	329	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

ZN507_HUMAN
NC score	0.003073 (rank : 118)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	739	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCN5	Gene names	ZNF507
Domain Architecture	No domain graphic available
Description	Zinc finger protein 507.

CD2L7_HUMAN
NC score	0.001704 (rank : 119)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	1275	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

TTBK2_MOUSE
NC score	0.001139 (rank : 120)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	811	Shared Neighborhood Hits	9
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

MAST3_HUMAN
NC score	0.000970 (rank : 121)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	1128	Shared Neighborhood Hits	17
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).