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Network neighborhood for query Sequence : PINL_HUMAN

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PINL_HUMAN
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PINL_HUMAN
θ value	3.974e-56 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PIN1_HUMAN
θ value	1.12775e-26 (rank : 2)	NC score	0.907056 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	4.43474e-23 (rank : 3)	NC score	0.898888 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWP1_MOUSE
θ value	2.44474e-05 (rank : 4)	NC score	0.450748 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	3.19293e-05 (rank : 5)	NC score	0.450527 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	177	Shared Neighborhood Hits	44
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	3.19293e-05 (rank : 6)	NC score	0.452552 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

ITCH_HUMAN
θ value	0.000158464 (rank : 7)	NC score	0.441119 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	0.000158464 (rank : 8)	NC score	0.444342 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	0.00020696 (rank : 9)	NC score	0.444130 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

GAS7_HUMAN
θ value	0.000270298 (rank : 10)	NC score	0.385361 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	258	Shared Neighborhood Hits	41
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	0.000461057 (rank : 11)	NC score	0.388890 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SMUF2_HUMAN
θ value	0.000602161 (rank : 12)	NC score	0.412914 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

PCIF1_HUMAN
θ value	0.00102713 (rank : 13)	NC score	0.279361 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

PCIF1_MOUSE
θ value	0.00102713 (rank : 14)	NC score	0.282605 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P59114	Gene names	Pcif1
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

NED4L_MOUSE
θ value	0.00134147 (rank : 15)	NC score	0.391410 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	231	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
θ value	0.00228821 (rank : 16)	NC score	0.396586 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	212	Shared Neighborhood Hits	44
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

WWOX_HUMAN
θ value	0.00228821 (rank : 17)	NC score	0.348152 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	0.00228821 (rank : 18)	NC score	0.345149 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

NED4L_HUMAN
θ value	0.00298849 (rank : 19)	NC score	0.390116 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
θ value	0.00665767 (rank : 20)	NC score	0.392242 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	214	Shared Neighborhood Hits	43
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

WWTR1_HUMAN
θ value	0.0961366 (rank : 21)	NC score	0.351002 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	0.0961366 (rank : 22)	NC score	0.351807 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	54	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

SETD2_HUMAN
θ value	0.279714 (rank : 23)	NC score	0.154999 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	412	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SAV1_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.389075 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.387810 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

APBB2_HUMAN
θ value	0.62314 (rank : 26)	NC score	0.192009 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

YAP1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.316863 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	40
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.244684 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	513	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

APBB3_MOUSE
θ value	1.06291 (rank : 29)	NC score	0.166819 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

BAG3_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.277090 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	314	Shared Neighborhood Hits	34
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

APBB2_MOUSE
θ value	1.38821 (rank : 31)	NC score	0.179114 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	88	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

MAGI1_MOUSE
θ value	3.0926 (rank : 32)	NC score	0.185485 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	403	Shared Neighborhood Hits	38
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.187972 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	373	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.198748 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	370	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

STXB4_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.139223 (rank : 69)
Query Neighborhood Hits	47	Target Neighborhood Hits	616	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

WBP4_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.149324 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

MAGI1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.185743 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

PRP40_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.161054 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.158558 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	447	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

SMUF1_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.362140 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	135	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.367486 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

STXB4_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.139837 (rank : 68)
Query Neighborhood Hits	47	Target Neighborhood Hits	629	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

YAP1_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.393602 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

APBB3_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.155376 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB1_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.115268 (rank : 70)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.114875 (rank : 71)
Query Neighborhood Hits	47	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

USH1C_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.016589 (rank : 78)
Query Neighborhood Hits	47	Target Neighborhood Hits	557	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

DHRSX_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.052131 (rank : 75)
Query Neighborhood Hits	47	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

EDD1_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.175757 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.175971 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD1_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.164149 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.258405 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.259929 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.178509 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.181721 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.167751 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.169691 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.209846 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.215066 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.262364 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.263159 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	406	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.271633 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.271395 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

PIN4_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.172987 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y237	Gene names	PIN4
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Rotamase Pin4) (PPIase Pin4) (Parvulin 14) (Par14) (Peptidyl-prolyl cis/trans isomerase EPVH) (hPar14).

PIN4_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.173852 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWW6	Gene names	Pin4
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Rotamase Pin4) (PPIase Pin4).

PKHA5_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.161968 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RDH12_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.050141 (rank : 77)
Query Neighborhood Hits	47	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH14_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.050251 (rank : 76)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RHG12_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.058835 (rank : 74)
Query Neighborhood Hits	47	Target Neighborhood Hits	190	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.072885 (rank : 73)
Query Neighborhood Hits	47	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TRIPC_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.234716 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	319	Shared Neighborhood Hits	17
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.251633 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.248382 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.247871 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.246966 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WBP4_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.080085 (rank : 72)
Query Neighborhood Hits	47	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WWC1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.240860 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.231908 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

Hits sorted by NC score

PINL_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.974e-56 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PIN1_HUMAN
NC score	0.907056 (rank : 2)	θ value	1.12775e-26 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	59	Shared Neighborhood Hits	44
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
NC score	0.898888 (rank : 3)	θ value	4.43474e-23 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	60	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWP2_MOUSE
NC score	0.452552 (rank : 4)	θ value	3.19293e-05 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	44
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP1_MOUSE
NC score	0.450748 (rank : 5)	θ value	2.44474e-05 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
NC score	0.450527 (rank : 6)	θ value	3.19293e-05 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	177	Shared Neighborhood Hits	44
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

ITCH_MOUSE
NC score	0.444342 (rank : 7)	θ value	0.000158464 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	127	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
NC score	0.444130 (rank : 8)	θ value	0.00020696 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_HUMAN
NC score	0.441119 (rank : 9)	θ value	0.000158464 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	162	Shared Neighborhood Hits	42
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

SMUF2_HUMAN
NC score	0.412914 (rank : 10)	θ value	0.000602161 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NEDD4_MOUSE
NC score	0.396586 (rank : 11)	θ value	0.00228821 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	212	Shared Neighborhood Hits	44
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

YAP1_MOUSE
NC score	0.393602 (rank : 12)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	96	Shared Neighborhood Hits	40
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

NEDD4_HUMAN
NC score	0.392242 (rank : 13)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	214	Shared Neighborhood Hits	43
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.391410 (rank : 14)	θ value	0.00134147 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	231	Shared Neighborhood Hits	44
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.390116 (rank : 15)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

SAV1_HUMAN
NC score	0.389075 (rank : 16)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

GAS7_MOUSE
NC score	0.388890 (rank : 17)	θ value	0.000461057 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	259	Shared Neighborhood Hits	41
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SAV1_MOUSE
NC score	0.387810 (rank : 18)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

GAS7_HUMAN
NC score	0.385361 (rank : 19)	θ value	0.000270298 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	258	Shared Neighborhood Hits	41
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

SMUF1_MOUSE
NC score	0.367486 (rank : 20)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
NC score	0.362140 (rank : 21)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	135	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

WWTR1_MOUSE
NC score	0.351807 (rank : 22)	θ value	0.0961366 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	54	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.351002 (rank : 23)	θ value	0.0961366 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWOX_HUMAN
NC score	0.348152 (rank : 24)	θ value	0.00228821 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.345149 (rank : 25)	θ value	0.00228821 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

YAP1_HUMAN
NC score	0.316863 (rank : 26)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	40
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

PCIF1_MOUSE
NC score	0.282605 (rank : 27)	θ value	0.00102713 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	P59114	Gene names	Pcif1
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

PCIF1_HUMAN
NC score	0.279361 (rank : 28)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H4Z3, Q9NT85	Gene names	PCIF1, C20orf67
Domain Architecture
Description	Phosphorylated CTD-interacting factor 1.

BAG3_HUMAN
NC score	0.277090 (rank : 29)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	314	Shared Neighborhood Hits	34
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

K0317_HUMAN
NC score	0.271633 (rank : 30)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.271395 (rank : 31)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_MOUSE
NC score	0.263159 (rank : 32)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	406	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.262364 (rank : 33)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.259929 (rank : 34)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.258405 (rank : 35)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.251633 (rank : 36)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.248382 (rank : 37)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
NC score	0.247871 (rank : 38)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	47	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.246966 (rank : 39)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	47	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

BAG3_MOUSE
NC score	0.244684 (rank : 40)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	513	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

WWC1_HUMAN
NC score	0.240860 (rank : 41)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	47	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

TRIPC_HUMAN
NC score	0.234716 (rank : 42)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	47	Target Neighborhood Hits	319	Shared Neighborhood Hits	17
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

WWC1_MOUSE
NC score	0.231908 (rank : 43)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	47	Target Neighborhood Hits	290	Shared Neighborhood Hits	32
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

HERC5_HUMAN
NC score	0.215066 (rank : 44)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.209846 (rank : 45)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

MAGI2_MOUSE
NC score	0.198748 (rank : 46)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	370	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

APBB2_HUMAN
NC score	0.192009 (rank : 47)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	96	Shared Neighborhood Hits	28
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

MAGI2_HUMAN
NC score	0.187972 (rank : 48)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	373	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_HUMAN
NC score	0.185743 (rank : 49)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.185485 (rank : 50)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	403	Shared Neighborhood Hits	38
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

HECD3_MOUSE
NC score	0.181721 (rank : 51)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

APBB2_MOUSE
NC score	0.179114 (rank : 52)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	88	Shared Neighborhood Hits	24
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

HECD3_HUMAN
NC score	0.178509 (rank : 53)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.175971 (rank : 54)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.175757 (rank : 55)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

PIN4_MOUSE
NC score	0.173852 (rank : 56)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWW6	Gene names	Pin4
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Rotamase Pin4) (PPIase Pin4).

PIN4_HUMAN
NC score	0.172987 (rank : 57)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y237	Gene names	PIN4
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Rotamase Pin4) (PPIase Pin4) (Parvulin 14) (Par14) (Peptidyl-prolyl cis/trans isomerase EPVH) (hPar14).

HERC2_MOUSE
NC score	0.169691 (rank : 58)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.167751 (rank : 59)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	163	Shared Neighborhood Hits	13
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

APBB3_MOUSE
NC score	0.166819 (rank : 60)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

HECD1_HUMAN
NC score	0.164149 (rank : 61)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

PKHA5_HUMAN
NC score	0.161968 (rank : 62)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	455	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_HUMAN
NC score	0.161054 (rank : 63)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.158558 (rank : 64)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	447	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

APBB3_HUMAN
NC score	0.155376 (rank : 65)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

SETD2_HUMAN
NC score	0.154999 (rank : 66)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	412	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

WBP4_MOUSE
NC score	0.149324 (rank : 67)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

STXB4_MOUSE
NC score	0.139837 (rank : 68)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	629	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.139223 (rank : 69)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	616	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

APBB1_HUMAN
NC score	0.115268 (rank : 70)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_MOUSE
NC score	0.114875 (rank : 71)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

WBP4_HUMAN
NC score	0.080085 (rank : 72)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	47	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	O75554	Gene names	WBP4, FBP21, FNBP21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

RHG12_MOUSE
NC score	0.072885 (rank : 73)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	47	Target Neighborhood Hits	204	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_HUMAN
NC score	0.058835 (rank : 74)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	47	Target Neighborhood Hits	190	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DHRSX_HUMAN
NC score	0.052131 (rank : 75)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

RDH14_HUMAN
NC score	0.050251 (rank : 76)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH12_MOUSE
NC score	0.050141 (rank : 77)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

USH1C_MOUSE
NC score	0.016589 (rank : 78)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	557	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).