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Network neighborhood for query Sequence : HERC2_HUMAN

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HERC2_HUMAN
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HERC2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	163	Target Neighborhood Hits	163	Shared Neighborhood Hits	163
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	0 (rank : 2)	NC score	0.998295 (rank : 2)
Query Neighborhood Hits	163	Target Neighborhood Hits	167	Shared Neighborhood Hits	136
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD3_MOUSE
θ value	1.51363e-47 (rank : 3)	NC score	0.707255 (rank : 5)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	40
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
θ value	4.40402e-47 (rank : 4)	NC score	0.705388 (rank : 6)
Query Neighborhood Hits	163	Target Neighborhood Hits	49	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC3_HUMAN
θ value	1.19932e-44 (rank : 5)	NC score	0.836754 (rank : 3)
Query Neighborhood Hits	163	Target Neighborhood Hits	62	Shared Neighborhood Hits	57
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

NEK8_HUMAN
θ value	5.96599e-36 (rank : 6)	NC score	0.152896 (rank : 68)
Query Neighborhood Hits	163	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

RCBT2_MOUSE
θ value	2.26708e-35 (rank : 7)	NC score	0.530820 (rank : 44)
Query Neighborhood Hits	163	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

HERC5_HUMAN
θ value	3.27365e-34 (rank : 8)	NC score	0.823957 (rank : 4)
Query Neighborhood Hits	163	Target Neighborhood Hits	66	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

ITCH_HUMAN
θ value	4.72714e-33 (rank : 9)	NC score	0.618950 (rank : 23)
Query Neighborhood Hits	163	Target Neighborhood Hits	162	Shared Neighborhood Hits	40
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	8.06329e-33 (rank : 10)	NC score	0.623714 (rank : 17)
Query Neighborhood Hits	163	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

NEK8_MOUSE
θ value	8.06329e-33 (rank : 11)	NC score	0.152153 (rank : 69)
Query Neighborhood Hits	163	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

RCBT2_HUMAN
θ value	1.37539e-32 (rank : 12)	NC score	0.531039 (rank : 43)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT1_MOUSE
θ value	6.82597e-32 (rank : 13)	NC score	0.504914 (rank : 45)
Query Neighborhood Hits	163	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

SMUF2_HUMAN
θ value	1.98606e-31 (rank : 14)	NC score	0.624238 (rank : 15)
Query Neighborhood Hits	163	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

WWP1_HUMAN
θ value	2.59387e-31 (rank : 15)	NC score	0.611025 (rank : 28)
Query Neighborhood Hits	163	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	2.59387e-31 (rank : 16)	NC score	0.615863 (rank : 25)
Query Neighborhood Hits	163	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

HUWE1_HUMAN
θ value	5.77852e-31 (rank : 17)	NC score	0.620820 (rank : 22)
Query Neighborhood Hits	163	Target Neighborhood Hits	443	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	5.77852e-31 (rank : 18)	NC score	0.622474 (rank : 19)
Query Neighborhood Hits	163	Target Neighborhood Hits	406	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NEK9_HUMAN
θ value	5.77852e-31 (rank : 19)	NC score	0.158507 (rank : 66)
Query Neighborhood Hits	163	Target Neighborhood Hits	900	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	9.8567e-31 (rank : 20)	NC score	0.160490 (rank : 65)
Query Neighborhood Hits	163	Target Neighborhood Hits	890	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

RPGR_MOUSE
θ value	1.28732e-30 (rank : 21)	NC score	0.578496 (rank : 34)
Query Neighborhood Hits	163	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

WWP2_MOUSE
θ value	2.19584e-30 (rank : 22)	NC score	0.616294 (rank : 24)
Query Neighborhood Hits	163	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

RCBT1_HUMAN
θ value	2.86786e-30 (rank : 23)	NC score	0.503454 (rank : 46)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCC2_HUMAN
θ value	2.86786e-30 (rank : 24)	NC score	0.623731 (rank : 16)
Query Neighborhood Hits	163	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

SMUF1_MOUSE
θ value	1.08979e-29 (rank : 25)	NC score	0.622935 (rank : 18)
Query Neighborhood Hits	163	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF1_HUMAN
θ value	1.4233e-29 (rank : 26)	NC score	0.625217 (rank : 14)
Query Neighborhood Hits	163	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

WWP2_HUMAN
θ value	2.42779e-29 (rank : 27)	NC score	0.613846 (rank : 26)
Query Neighborhood Hits	163	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

RCC2_MOUSE
θ value	4.14116e-29 (rank : 28)	NC score	0.621070 (rank : 21)
Query Neighborhood Hits	163	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

SRGEF_MOUSE
θ value	7.06379e-29 (rank : 29)	NC score	0.622306 (rank : 20)
Query Neighborhood Hits	163	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_HUMAN
θ value	9.2256e-29 (rank : 30)	NC score	0.625349 (rank : 12)
Query Neighborhood Hits	163	Target Neighborhood Hits	33	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

NED4L_HUMAN
θ value	1.73987e-27 (rank : 31)	NC score	0.568761 (rank : 39)
Query Neighborhood Hits	163	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	1.73987e-27 (rank : 32)	NC score	0.569403 (rank : 38)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

RPGR_HUMAN
θ value	1.73987e-27 (rank : 33)	NC score	0.575354 (rank : 36)
Query Neighborhood Hits	163	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

NEDD4_MOUSE
θ value	2.96777e-27 (rank : 34)	NC score	0.582694 (rank : 33)
Query Neighborhood Hits	163	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
θ value	5.06226e-27 (rank : 35)	NC score	0.578393 (rank : 35)
Query Neighborhood Hits	163	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

RCC1_HUMAN
θ value	8.63488e-27 (rank : 36)	NC score	0.612900 (rank : 27)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

UBE3A_HUMAN
θ value	3.62785e-25 (rank : 37)	NC score	0.644925 (rank : 7)
Query Neighborhood Hits	163	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

RCC1_MOUSE
θ value	4.9032e-22 (rank : 38)	NC score	0.599381 (rank : 32)
Query Neighborhood Hits	163	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

TRIPC_HUMAN
θ value	1.86321e-21 (rank : 39)	NC score	0.602766 (rank : 31)
Query Neighborhood Hits	163	Target Neighborhood Hits	319	Shared Neighborhood Hits	37
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_MOUSE
θ value	9.24701e-21 (rank : 40)	NC score	0.635475 (rank : 8)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

CUL7_HUMAN
θ value	1.5773e-20 (rank : 41)	NC score	0.329818 (rank : 51)
Query Neighborhood Hits	163	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

UBE3C_HUMAN
θ value	1.02238e-19 (rank : 42)	NC score	0.626731 (rank : 11)
Query Neighborhood Hits	163	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

PARC_HUMAN
θ value	1.74391e-19 (rank : 43)	NC score	0.260986 (rank : 54)
Query Neighborhood Hits	163	Target Neighborhood Hits	148	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
θ value	1.74391e-19 (rank : 44)	NC score	0.267482 (rank : 53)
Query Neighborhood Hits	163	Target Neighborhood Hits	114	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

UBE3C_MOUSE
θ value	2.97466e-19 (rank : 45)	NC score	0.625307 (rank : 13)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

HECD2_HUMAN
θ value	6.62687e-19 (rank : 46)	NC score	0.632331 (rank : 10)
Query Neighborhood Hits	163	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	1.92812e-18 (rank : 47)	NC score	0.632796 (rank : 9)
Query Neighborhood Hits	163	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD1_HUMAN
θ value	2.5182e-18 (rank : 48)	NC score	0.446430 (rank : 47)
Query Neighborhood Hits	163	Target Neighborhood Hits	371	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

WBS16_HUMAN
θ value	5.60996e-18 (rank : 49)	NC score	0.570097 (rank : 37)
Query Neighborhood Hits	163	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	1.63225e-17 (rank : 50)	NC score	0.568688 (rank : 40)
Query Neighborhood Hits	163	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

ALS2_HUMAN
θ value	8.95645e-16 (rank : 51)	NC score	0.416483 (rank : 48)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

EDD1_HUMAN
θ value	8.95645e-16 (rank : 52)	NC score	0.533940 (rank : 42)
Query Neighborhood Hits	163	Target Neighborhood Hits	170	Shared Neighborhood Hits	42
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	8.95645e-16 (rank : 53)	NC score	0.534297 (rank : 41)
Query Neighborhood Hits	163	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

ALS2_MOUSE
θ value	1.52774e-15 (rank : 54)	NC score	0.410975 (rank : 49)
Query Neighborhood Hits	163	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

K0317_HUMAN
θ value	1.68911e-14 (rank : 55)	NC score	0.604028 (rank : 29)
Query Neighborhood Hits	163	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	3.76295e-14 (rank : 56)	NC score	0.603178 (rank : 30)
Query Neighborhood Hits	163	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

MIB2_HUMAN
θ value	4.59992e-12 (rank : 57)	NC score	0.114879 (rank : 85)
Query Neighborhood Hits	163	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
θ value	1.133e-10 (rank : 58)	NC score	0.114574 (rank : 86)
Query Neighborhood Hits	163	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

MYCB2_MOUSE
θ value	1.133e-10 (rank : 59)	NC score	0.329816 (rank : 52)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MIB1_HUMAN
θ value	1.9326e-10 (rank : 60)	NC score	0.102191 (rank : 94)
Query Neighborhood Hits	163	Target Neighborhood Hits	470	Shared Neighborhood Hits	26
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	1.9326e-10 (rank : 61)	NC score	0.102342 (rank : 93)
Query Neighborhood Hits	163	Target Neighborhood Hits	471	Shared Neighborhood Hits	26
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MYCB2_HUMAN
θ value	1.9326e-10 (rank : 62)	NC score	0.330484 (rank : 50)
Query Neighborhood Hits	163	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

ZSWM2_HUMAN
θ value	3.19293e-05 (rank : 63)	NC score	0.139903 (rank : 74)
Query Neighborhood Hits	163	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NEG5	Gene names	ZSWIM2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

SQSTM_MOUSE
θ value	4.1701e-05 (rank : 64)	NC score	0.175867 (rank : 62)
Query Neighborhood Hits	163	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

SQSTM_HUMAN
θ value	5.44631e-05 (rank : 65)	NC score	0.175540 (rank : 63)
Query Neighborhood Hits	163	Target Neighborhood Hits	61	Shared Neighborhood Hits	21
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

CYB5_HUMAN
θ value	0.000270298 (rank : 66)	NC score	0.154524 (rank : 67)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P00167	Gene names	CYB5
Domain Architecture
Description	Cytochrome b5.

ZSWM2_MOUSE
θ value	0.00035302 (rank : 67)	NC score	0.126554 (rank : 81)
Query Neighborhood Hits	163	Target Neighborhood Hits	132	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D9X6	Gene names	Zswim2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

APC10_HUMAN
θ value	0.000602161 (rank : 68)	NC score	0.204778 (rank : 57)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

CYB5B_MOUSE
θ value	0.000602161 (rank : 69)	NC score	0.146843 (rank : 72)
Query Neighborhood Hits	163	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CQX2, Q9D1M6, Q9D8R3	Gene names	Cyb5b, Cyb5m
Domain Architecture	No domain graphic available
Description	Cytochrome b5 type B precursor (Cytochrome b5 outer mitochondrial membrane isoform).

APC10_MOUSE
θ value	0.00102713 (rank : 70)	NC score	0.199611 (rank : 59)
Query Neighborhood Hits	163	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

CYB5B_HUMAN
θ value	0.00175202 (rank : 71)	NC score	0.139260 (rank : 77)
Query Neighborhood Hits	163	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O43169, Q96CC3, Q9BT35	Gene names	CYB5B, CYB5M, OMB5
Domain Architecture
Description	Cytochrome b5 type B precursor (Cytochrome b5 outer mitochondrial membrane isoform).

DTNA_HUMAN
θ value	0.00228821 (rank : 72)	NC score	0.108650 (rank : 89)
Query Neighborhood Hits	163	Target Neighborhood Hits	295	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

DTNA_MOUSE
θ value	0.00298849 (rank : 73)	NC score	0.111738 (rank : 87)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

CYB5_MOUSE
θ value	0.00665767 (rank : 74)	NC score	0.131806 (rank : 79)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	P56395	Gene names	Cyb5
Domain Architecture
Description	Cytochrome b5.

DTNB_HUMAN
θ value	0.00665767 (rank : 75)	NC score	0.107385 (rank : 90)
Query Neighborhood Hits	163	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	O60941, O43782, O60881, O75538, Q9UE14, Q9UE15, Q9UE16	Gene names	DTNB
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B).

DTNB_MOUSE
θ value	0.00869519 (rank : 76)	NC score	0.103785 (rank : 92)
Query Neighborhood Hits	163	Target Neighborhood Hits	263	Shared Neighborhood Hits	20
SwissProt Accessions	O70585, O70563, Q9CTZ1	Gene names	Dtnb
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B) (MDTN-B).

FBX24_HUMAN
θ value	0.0148317 (rank : 77)	NC score	0.232691 (rank : 55)
Query Neighborhood Hits	163	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

DRP2_HUMAN
θ value	0.0252991 (rank : 78)	NC score	0.106246 (rank : 91)
Query Neighborhood Hits	163	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

FBX24_MOUSE
θ value	0.0330416 (rank : 79)	NC score	0.209229 (rank : 56)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

EP300_HUMAN
θ value	0.0961366 (rank : 80)	NC score	0.046325 (rank : 114)
Query Neighborhood Hits	163	Target Neighborhood Hits	821	Shared Neighborhood Hits	21
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

NBR1_HUMAN
θ value	0.0961366 (rank : 81)	NC score	0.080307 (rank : 102)
Query Neighborhood Hits	163	Target Neighborhood Hits	105	Shared Neighborhood Hits	20
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

MFGM_MOUSE
θ value	0.21417 (rank : 82)	NC score	0.019637 (rank : 134)
Query Neighborhood Hits	163	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	P21956, P97800, Q3TBN5, Q9R1X9, Q9WTS3	Gene names	Mfge8
Domain Architecture
Description	Lactadherin precursor (Milk fat globule-EGF factor 8) (MFG-E8) (MFGM) (Sperm surface protein SP47) (MP47).

CBP_HUMAN
θ value	0.279714 (rank : 83)	NC score	0.046181 (rank : 115)
Query Neighborhood Hits	163	Target Neighborhood Hits	941	Shared Neighborhood Hits	27
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	0.279714 (rank : 84)	NC score	0.042553 (rank : 120)
Query Neighborhood Hits	163	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

HEMK1_MOUSE
θ value	0.365318 (rank : 85)	NC score	0.043782 (rank : 117)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q921L7	Gene names	Hemk1
Domain Architecture	No domain graphic available
Description	HemK methyltransferase family member 1 (EC 2.1.1.-).

LRFN4_HUMAN
θ value	0.365318 (rank : 86)	NC score	0.009347 (rank : 154)
Query Neighborhood Hits	163	Target Neighborhood Hits	462	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MAK_MOUSE
θ value	0.365318 (rank : 87)	NC score	0.017861 (rank : 139)
Query Neighborhood Hits	163	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

NACAM_MOUSE
θ value	0.62314 (rank : 88)	NC score	0.024024 (rank : 128)
Query Neighborhood Hits	163	Target Neighborhood Hits	1866	Shared Neighborhood Hits	28
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

TOP2A_HUMAN
θ value	0.62314 (rank : 89)	NC score	0.020384 (rank : 133)
Query Neighborhood Hits	163	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

DMD_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.042947 (rank : 119)
Query Neighborhood Hits	163	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	0.813845 (rank : 91)	NC score	0.038948 (rank : 122)
Query Neighborhood Hits	163	Target Neighborhood Hits	1111	Shared Neighborhood Hits	31
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

SUOX_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.053617 (rank : 112)
Query Neighborhood Hits	163	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P51687	Gene names	SUOX
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

UTRO_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.041256 (rank : 121)
Query Neighborhood Hits	163	Target Neighborhood Hits	960	Shared Neighborhood Hits	34
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

GON4L_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.022498 (rank : 129)
Query Neighborhood Hits	163	Target Neighborhood Hits	555	Shared Neighborhood Hits	14
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

SAKS1_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.047166 (rank : 113)
Query Neighborhood Hits	163	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q04323, Q9BV93, Q9BVV5	Gene names	SAKS1
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein).

SAKS1_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.046073 (rank : 116)
Query Neighborhood Hits	163	Target Neighborhood Hits	208	Shared Neighborhood Hits	8
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

SMG1_HUMAN
θ value	1.06291 (rank : 97)	NC score	0.021493 (rank : 132)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

SMG1_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.021788 (rank : 131)
Query Neighborhood Hits	163	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

XRCC4_MOUSE
θ value	1.06291 (rank : 99)	NC score	0.035672 (rank : 123)
Query Neighborhood Hits	163	Target Neighborhood Hits	104	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T3, Q8BKC9, Q8BU02, Q9D6U6	Gene names	Xrcc4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

ZNF85_HUMAN
θ value	1.06291 (rank : 100)	NC score	-0.004004 (rank : 192)
Query Neighborhood Hits	163	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	Q03923	Gene names	ZNF85
Domain Architecture
Description	Zinc finger protein 85 (Zinc finger protein HPF4) (HTF1).

ABCAD_HUMAN
θ value	1.38821 (rank : 101)	NC score	0.009788 (rank : 152)
Query Neighborhood Hits	163	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UQ4, Q6ZTT7, Q86WI2, Q8N248	Gene names	ABCA13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

DDX27_HUMAN
θ value	1.81305 (rank : 102)	NC score	0.005125 (rank : 170)
Query Neighborhood Hits	163	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

ERCC5_MOUSE
θ value	1.81305 (rank : 103)	NC score	0.024925 (rank : 127)
Query Neighborhood Hits	163	Target Neighborhood Hits	206	Shared Neighborhood Hits	10
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

HIPK1_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.015466 (rank : 143)
Query Neighborhood Hits	163	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

MPP8_HUMAN
θ value	1.81305 (rank : 105)	NC score	0.027765 (rank : 126)
Query Neighborhood Hits	163	Target Neighborhood Hits	948	Shared Neighborhood Hits	17
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

NBR1_MOUSE
θ value	1.81305 (rank : 106)	NC score	0.058424 (rank : 106)
Query Neighborhood Hits	163	Target Neighborhood Hits	116	Shared Neighborhood Hits	17
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

CRLF2_MOUSE
θ value	2.36792 (rank : 107)	NC score	0.019459 (rank : 135)
Query Neighborhood Hits	163	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

ADAM9_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.003459 (rank : 179)
Query Neighborhood Hits	163	Target Neighborhood Hits	325	Shared Neighborhood Hits	5
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

KPCE_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.013951 (rank : 149)
Query Neighborhood Hits	163	Target Neighborhood Hits	906	Shared Neighborhood Hits	14
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MYST4_HUMAN
θ value	3.0926 (rank : 110)	NC score	0.009099 (rank : 155)
Query Neighborhood Hits	163	Target Neighborhood Hits	671	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

SUOX_MOUSE
θ value	3.0926 (rank : 111)	NC score	0.043202 (rank : 118)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R086	Gene names	Suox
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

TLN1_HUMAN
θ value	3.0926 (rank : 112)	NC score	0.007660 (rank : 160)
Query Neighborhood Hits	163	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TTBK2_MOUSE
θ value	3.0926 (rank : 113)	NC score	0.014835 (rank : 148)
Query Neighborhood Hits	163	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

WDR67_HUMAN
θ value	3.0926 (rank : 114)	NC score	0.006000 (rank : 165)
Query Neighborhood Hits	163	Target Neighborhood Hits	782	Shared Neighborhood Hits	9
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

NNTM_MOUSE
θ value	4.03905 (rank : 115)	NC score	0.017586 (rank : 141)
Query Neighborhood Hits	163	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

NTRI_MOUSE
θ value	4.03905 (rank : 116)	NC score	0.004454 (rank : 173)
Query Neighborhood Hits	163	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

SLAF7_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.016290 (rank : 142)
Query Neighborhood Hits	163	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQ25, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23	Gene names	SLAMF7, CS1
Domain Architecture	No domain graphic available
Description	SLAM family member 7 precursor (CD2-like receptor activating cytotoxic cells) (CRACC) (Protein 19A) (CD2 subset 1) (Novel Ly9) (Membrane protein FOAP-12) (CD319 antigen).

CN046_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.029161 (rank : 124)
Query Neighborhood Hits	163	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q52LA3	Gene names	C14orf46
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf46.

CN046_MOUSE
θ value	5.27518 (rank : 119)	NC score	0.029161 (rank : 125)
Query Neighborhood Hits	163	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CD94	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf46 homolog.

DICER_HUMAN
θ value	5.27518 (rank : 120)	NC score	0.015036 (rank : 145)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
θ value	5.27518 (rank : 121)	NC score	0.014926 (rank : 146)
Query Neighborhood Hits	163	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

GP110_MOUSE
θ value	5.27518 (rank : 122)	NC score	0.006623 (rank : 163)
Query Neighborhood Hits	163	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEC3, Q8BMV8	Gene names	Gpr110
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 110 precursor.

MPDZ_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.001158 (rank : 188)
Query Neighborhood Hits	163	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

MYST3_HUMAN
θ value	5.27518 (rank : 124)	NC score	0.008645 (rank : 157)
Query Neighborhood Hits	163	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NTRI_HUMAN
θ value	5.27518 (rank : 125)	NC score	0.003729 (rank : 178)
Query Neighborhood Hits	163	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

PHF22_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.014900 (rank : 147)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

POZP3_HUMAN
θ value	5.27518 (rank : 127)	NC score	0.009420 (rank : 153)
Query Neighborhood Hits	163	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PJE2, Q12903, Q9BWB4	Gene names	POMZP3
Domain Architecture	No domain graphic available
Description	POM121 and ZP3 fusion protein (POM-ZP3).

SM1L2_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.003013 (rank : 184)
Query Neighborhood Hits	163	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SRBP1_HUMAN
θ value	5.27518 (rank : 129)	NC score	0.006967 (rank : 162)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

STRAP_HUMAN
θ value	5.27518 (rank : 130)	NC score	0.005801 (rank : 166)
Query Neighborhood Hits	163	Target Neighborhood Hits	272	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

STRAP_MOUSE
θ value	5.27518 (rank : 131)	NC score	0.005660 (rank : 167)
Query Neighborhood Hits	163	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

ZN431_HUMAN
θ value	5.27518 (rank : 132)	NC score	-0.005269 (rank : 193)
Query Neighborhood Hits	163	Target Neighborhood Hits	765	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TF32, Q8IWC4	Gene names	ZNF431, KIAA1969
Domain Architecture
Description	Zinc finger protein 431.

ANK3_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.022120 (rank : 130)
Query Neighborhood Hits	163	Target Neighborhood Hits	853	Shared Neighborhood Hits	22
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

HSH2D_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.011374 (rank : 151)
Query Neighborhood Hits	163	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

LRC25_HUMAN
θ value	6.88961 (rank : 135)	NC score	0.018277 (rank : 137)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N386, Q8N9A5	Gene names	LRRC25, MAPA
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 25 precursor (Monocyte and plasmacytoid-activated protein).

PDZD8_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.019443 (rank : 136)
Query Neighborhood Hits	163	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SO3A1_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.004304 (rank : 175)
Query Neighborhood Hits	163	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UIG8, Q9BW73, Q9GZV2	Gene names	SLCO3A1, OATPD, SLC21A11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (PGE1 transporter).

SO3A1_MOUSE
θ value	6.88961 (rank : 138)	NC score	0.004295 (rank : 176)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3L5, Q9CTV3, Q9JKV0	Gene names	Slco3a1, Oatpd, Slc21a11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (MJAM).

SYNJ2_MOUSE
θ value	6.88961 (rank : 139)	NC score	0.004354 (rank : 174)
Query Neighborhood Hits	163	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

TLN1_MOUSE
θ value	6.88961 (rank : 140)	NC score	0.006258 (rank : 164)
Query Neighborhood Hits	163	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

U3IP2_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.003383 (rank : 180)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	8
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

CN155_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.015388 (rank : 144)
Query Neighborhood Hits	163	Target Neighborhood Hits	385	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CSAD_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.008368 (rank : 159)
Query Neighborhood Hits	163	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y600, Q9UNJ5, Q9Y601	Gene names	CSAD, CSD
Domain Architecture
Description	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Sulfinoalanine decarboxylase) (Cysteine-sulfinate decarboxylase).

CSAD_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.008412 (rank : 158)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBE0	Gene names	Csad
Domain Architecture
Description	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Sulfinoalanine decarboxylase) (Cysteine-sulfinate decarboxylase).

DDX27_MOUSE
θ value	8.99809 (rank : 145)	NC score	0.003215 (rank : 182)
Query Neighborhood Hits	163	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DUS4_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.004933 (rank : 172)
Query Neighborhood Hits	163	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

DUS4_MOUSE
θ value	8.99809 (rank : 147)	NC score	0.004970 (rank : 171)
Query Neighborhood Hits	163	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

ERCC6_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.002990 (rank : 185)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	5
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

FBN1_HUMAN
θ value	8.99809 (rank : 149)	NC score	-0.002408 (rank : 191)
Query Neighborhood Hits	163	Target Neighborhood Hits	557	Shared Neighborhood Hits	5
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

ITA5_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.003111 (rank : 183)
Query Neighborhood Hits	163	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P08648, Q96HA5	Gene names	ITGA5, FNRA
Domain Architecture
Description	Integrin alpha-5 precursor (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD49e antigen) [Contains: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain].

KIF17_HUMAN
θ value	8.99809 (rank : 151)	NC score	-0.000455 (rank : 189)
Query Neighborhood Hits	163	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

MFN2_MOUSE
θ value	8.99809 (rank : 152)	NC score	0.012544 (rank : 150)
Query Neighborhood Hits	163	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U63, Q3V3B8, Q80WP4, Q80XK3, Q8BHF0, Q8BKV5, Q8R535, Q923X2	Gene names	Mfn2, Kiaa0214, Marf
Domain Architecture
Description	Transmembrane GTPase MFN2 (EC 3.6.5.-) (Mitofusin-2) (Hypertension- related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein).

PK1IP_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.003311 (rank : 181)
Query Neighborhood Hits	163	Target Neighborhood Hits	313	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

RN168_MOUSE
θ value	8.99809 (rank : 154)	NC score	0.002711 (rank : 187)
Query Neighborhood Hits	163	Target Neighborhood Hits	440	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

S39A4_MOUSE
θ value	8.99809 (rank : 155)	NC score	0.005573 (rank : 168)
Query Neighborhood Hits	163	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q78IQ7, Q8CHL4	Gene names	Slc39a4, Zip4
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4) (Activated in W/Wv mouse stomach 2) (mAWMS2).

SLIK3_MOUSE
θ value	8.99809 (rank : 156)	NC score	-0.000638 (rank : 190)
Query Neighborhood Hits	163	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B9	Gene names	Slitrk3
Domain Architecture
Description	SLIT and NTRK-like protein 3 precursor.

SMAL1_MOUSE
θ value	8.99809 (rank : 157)	NC score	0.002805 (rank : 186)
Query Neighborhood Hits	163	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

SMRC2_HUMAN
θ value	8.99809 (rank : 158)	NC score	0.007282 (rank : 161)
Query Neighborhood Hits	163	Target Neighborhood Hits	499	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SMRC2_MOUSE
θ value	8.99809 (rank : 159)	NC score	0.008915 (rank : 156)
Query Neighborhood Hits	163	Target Neighborhood Hits	487	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

STX18_HUMAN
θ value	8.99809 (rank : 160)	NC score	0.005364 (rank : 169)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

TNR1A_HUMAN
θ value	8.99809 (rank : 161)	NC score	0.003877 (rank : 177)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

UBP5_HUMAN
θ value	8.99809 (rank : 162)	NC score	0.017741 (rank : 140)
Query Neighborhood Hits	163	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

UBP5_MOUSE
θ value	8.99809 (rank : 163)	NC score	0.018085 (rank : 138)
Query Neighborhood Hits	163	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

ABTB2_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.054714 (rank : 110)
Query Neighborhood Hits	163	Target Neighborhood Hits	391	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.057114 (rank : 107)
Query Neighborhood Hits	163	Target Neighborhood Hits	414	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

APBB2_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.058796 (rank : 105)
Query Neighborhood Hits	163	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.056604 (rank : 108)
Query Neighborhood Hits	163	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

BAG3_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.131202 (rank : 80)
Query Neighborhood Hits	163	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.110706 (rank : 88)
Query Neighborhood Hits	163	Target Neighborhood Hits	513	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

GAS7_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.087499 (rank : 100)
Query Neighborhood Hits	163	Target Neighborhood Hits	258	Shared Neighborhood Hits	15
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.087349 (rank : 101)
Query Neighborhood Hits	163	Target Neighborhood Hits	259	Shared Neighborhood Hits	15
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

MAGI1_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.091548 (rank : 99)
Query Neighborhood Hits	163	Target Neighborhood Hits	388	Shared Neighborhood Hits	20
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 173)	NC score	0.092029 (rank : 98)
Query Neighborhood Hits	163	Target Neighborhood Hits	403	Shared Neighborhood Hits	20
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.092341 (rank : 97)
Query Neighborhood Hits	163	Target Neighborhood Hits	373	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 175)	NC score	0.099278 (rank : 95)
Query Neighborhood Hits	163	Target Neighborhood Hits	370	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PIN1_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.140901 (rank : 73)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.139848 (rank : 75)
Query Neighborhood Hits	163	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.167751 (rank : 64)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PKHA5_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.098118 (rank : 96)
Query Neighborhood Hits	163	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.074043 (rank : 104)
Query Neighborhood Hits	163	Target Neighborhood Hits	442	Shared Neighborhood Hits	21
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.075263 (rank : 103)
Query Neighborhood Hits	163	Target Neighborhood Hits	447	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

SAV1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.179683 (rank : 61)
Query Neighborhood Hits	163	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.179896 (rank : 60)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

STXB4_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.054979 (rank : 109)
Query Neighborhood Hits	163	Target Neighborhood Hits	616	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.054250 (rank : 111)
Query Neighborhood Hits	163	Target Neighborhood Hits	629	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

WWC1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.148642 (rank : 71)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.149512 (rank : 70)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.139587 (rank : 76)
Query Neighborhood Hits	163	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.138340 (rank : 78)
Query Neighborhood Hits	163	Target Neighborhood Hits	118	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWTR1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.119540 (rank : 83)
Query Neighborhood Hits	163	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.122090 (rank : 82)
Query Neighborhood Hits	163	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.116711 (rank : 84)
Query Neighborhood Hits	163	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.199636 (rank : 58)
Query Neighborhood Hits	163	Target Neighborhood Hits	96	Shared Neighborhood Hits	17
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

HERC2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	163	Target Neighborhood Hits	163	Shared Neighborhood Hits	163
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.998295 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	163	Target Neighborhood Hits	167	Shared Neighborhood Hits	136
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
NC score	0.836754 (rank : 3)	θ value	1.19932e-44 (rank : 5)
Query Neighborhood Hits	163	Target Neighborhood Hits	62	Shared Neighborhood Hits	57
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
NC score	0.823957 (rank : 4)	θ value	3.27365e-34 (rank : 8)
Query Neighborhood Hits	163	Target Neighborhood Hits	66	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HECD3_MOUSE
NC score	0.707255 (rank : 5)	θ value	1.51363e-47 (rank : 3)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	40
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.705388 (rank : 6)	θ value	4.40402e-47 (rank : 4)
Query Neighborhood Hits	163	Target Neighborhood Hits	49	Shared Neighborhood Hits	40
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

UBE3A_HUMAN
NC score	0.644925 (rank : 7)	θ value	3.62785e-25 (rank : 37)
Query Neighborhood Hits	163	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.635475 (rank : 8)	θ value	9.24701e-21 (rank : 40)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HECD2_MOUSE
NC score	0.632796 (rank : 9)	θ value	1.92812e-18 (rank : 47)
Query Neighborhood Hits	163	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.632331 (rank : 10)	θ value	6.62687e-19 (rank : 46)
Query Neighborhood Hits	163	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3C_HUMAN
NC score	0.626731 (rank : 11)	θ value	1.02238e-19 (rank : 42)
Query Neighborhood Hits	163	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

SRGEF_HUMAN
NC score	0.625349 (rank : 12)	θ value	9.2256e-29 (rank : 30)
Query Neighborhood Hits	163	Target Neighborhood Hits	33	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

UBE3C_MOUSE
NC score	0.625307 (rank : 13)	θ value	2.97466e-19 (rank : 45)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	34
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

SMUF1_HUMAN
NC score	0.625217 (rank : 14)	θ value	1.4233e-29 (rank : 26)
Query Neighborhood Hits	163	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF2_HUMAN
NC score	0.624238 (rank : 15)	θ value	1.98606e-31 (rank : 14)
Query Neighborhood Hits	163	Target Neighborhood Hits	142	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

RCC2_HUMAN
NC score	0.623731 (rank : 16)	θ value	2.86786e-30 (rank : 24)
Query Neighborhood Hits	163	Target Neighborhood Hits	36	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

ITCH_MOUSE
NC score	0.623714 (rank : 17)	θ value	8.06329e-33 (rank : 10)
Query Neighborhood Hits	163	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

SMUF1_MOUSE
NC score	0.622935 (rank : 18)	θ value	1.08979e-29 (rank : 25)
Query Neighborhood Hits	163	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

HUWE1_MOUSE
NC score	0.622474 (rank : 19)	θ value	5.77852e-31 (rank : 18)
Query Neighborhood Hits	163	Target Neighborhood Hits	406	Shared Neighborhood Hits	40
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

SRGEF_MOUSE
NC score	0.622306 (rank : 20)	θ value	7.06379e-29 (rank : 29)
Query Neighborhood Hits	163	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC2_MOUSE
NC score	0.621070 (rank : 21)	θ value	4.14116e-29 (rank : 28)
Query Neighborhood Hits	163	Target Neighborhood Hits	37	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

HUWE1_HUMAN
NC score	0.620820 (rank : 22)	θ value	5.77852e-31 (rank : 17)
Query Neighborhood Hits	163	Target Neighborhood Hits	443	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

ITCH_HUMAN
NC score	0.618950 (rank : 23)	θ value	4.72714e-33 (rank : 9)
Query Neighborhood Hits	163	Target Neighborhood Hits	162	Shared Neighborhood Hits	40
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP2_MOUSE
NC score	0.616294 (rank : 24)	θ value	2.19584e-30 (rank : 22)
Query Neighborhood Hits	163	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP1_MOUSE
NC score	0.615863 (rank : 25)	θ value	2.59387e-31 (rank : 16)
Query Neighborhood Hits	163	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
NC score	0.613846 (rank : 26)	θ value	2.42779e-29 (rank : 27)
Query Neighborhood Hits	163	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

RCC1_HUMAN
NC score	0.612900 (rank : 27)	θ value	8.63488e-27 (rank : 36)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

WWP1_HUMAN
NC score	0.611025 (rank : 28)	θ value	2.59387e-31 (rank : 15)
Query Neighborhood Hits	163	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

K0317_HUMAN
NC score	0.604028 (rank : 29)	θ value	1.68911e-14 (rank : 55)
Query Neighborhood Hits	163	Target Neighborhood Hits	46	Shared Neighborhood Hits	33
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.603178 (rank : 30)	θ value	3.76295e-14 (rank : 56)
Query Neighborhood Hits	163	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

TRIPC_HUMAN
NC score	0.602766 (rank : 31)	θ value	1.86321e-21 (rank : 39)
Query Neighborhood Hits	163	Target Neighborhood Hits	319	Shared Neighborhood Hits	37
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

RCC1_MOUSE
NC score	0.599381 (rank : 32)	θ value	4.9032e-22 (rank : 38)
Query Neighborhood Hits	163	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

NEDD4_MOUSE
NC score	0.582694 (rank : 33)	θ value	2.96777e-27 (rank : 34)
Query Neighborhood Hits	163	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

RPGR_MOUSE
NC score	0.578496 (rank : 34)	θ value	1.28732e-30 (rank : 21)
Query Neighborhood Hits	163	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

NEDD4_HUMAN
NC score	0.578393 (rank : 35)	θ value	5.06226e-27 (rank : 35)
Query Neighborhood Hits	163	Target Neighborhood Hits	214	Shared Neighborhood Hits	37
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

RPGR_HUMAN
NC score	0.575354 (rank : 36)	θ value	1.73987e-27 (rank : 33)
Query Neighborhood Hits	163	Target Neighborhood Hits	279	Shared Neighborhood Hits	35
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

WBS16_HUMAN
NC score	0.570097 (rank : 37)	θ value	5.60996e-18 (rank : 49)
Query Neighborhood Hits	163	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

NED4L_MOUSE
NC score	0.569403 (rank : 38)	θ value	1.73987e-27 (rank : 32)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.568761 (rank : 39)	θ value	1.73987e-27 (rank : 31)
Query Neighborhood Hits	163	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

WBS16_MOUSE
NC score	0.568688 (rank : 40)	θ value	1.63225e-17 (rank : 50)
Query Neighborhood Hits	163	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

EDD1_MOUSE
NC score	0.534297 (rank : 41)	θ value	8.95645e-16 (rank : 53)
Query Neighborhood Hits	163	Target Neighborhood Hits	167	Shared Neighborhood Hits	41
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.533940 (rank : 42)	θ value	8.95645e-16 (rank : 52)
Query Neighborhood Hits	163	Target Neighborhood Hits	170	Shared Neighborhood Hits	42
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

RCBT2_HUMAN
NC score	0.531039 (rank : 43)	θ value	1.37539e-32 (rank : 12)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
NC score	0.530820 (rank : 44)	θ value	2.26708e-35 (rank : 7)
Query Neighborhood Hits	163	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCBT1_MOUSE
NC score	0.504914 (rank : 45)	θ value	6.82597e-32 (rank : 13)
Query Neighborhood Hits	163	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT1_HUMAN
NC score	0.503454 (rank : 46)	θ value	2.86786e-30 (rank : 23)
Query Neighborhood Hits	163	Target Neighborhood Hits	158	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

HECD1_HUMAN
NC score	0.446430 (rank : 47)	θ value	2.5182e-18 (rank : 48)
Query Neighborhood Hits	163	Target Neighborhood Hits	371	Shared Neighborhood Hits	41
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ALS2_HUMAN
NC score	0.416483 (rank : 48)	θ value	8.95645e-16 (rank : 51)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
NC score	0.410975 (rank : 49)	θ value	1.52774e-15 (rank : 54)
Query Neighborhood Hits	163	Target Neighborhood Hits	111	Shared Neighborhood Hits	28
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

MYCB2_HUMAN
NC score	0.330484 (rank : 50)	θ value	1.9326e-10 (rank : 62)
Query Neighborhood Hits	163	Target Neighborhood Hits	390	Shared Neighborhood Hits	38
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

CUL7_HUMAN
NC score	0.329818 (rank : 51)	θ value	1.5773e-20 (rank : 41)
Query Neighborhood Hits	163	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

MYCB2_MOUSE
NC score	0.329816 (rank : 52)	θ value	1.133e-10 (rank : 59)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

PARC_MOUSE
NC score	0.267482 (rank : 53)	θ value	1.74391e-19 (rank : 44)
Query Neighborhood Hits	163	Target Neighborhood Hits	114	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PARC_HUMAN
NC score	0.260986 (rank : 54)	θ value	1.74391e-19 (rank : 43)
Query Neighborhood Hits	163	Target Neighborhood Hits	148	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

FBX24_HUMAN
NC score	0.232691 (rank : 55)	θ value	0.0148317 (rank : 77)
Query Neighborhood Hits	163	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

FBX24_MOUSE
NC score	0.209229 (rank : 56)	θ value	0.0330416 (rank : 79)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

APC10_HUMAN
NC score	0.204778 (rank : 57)	θ value	0.000602161 (rank : 68)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

YAP1_MOUSE
NC score	0.199636 (rank : 58)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	163	Target Neighborhood Hits	96	Shared Neighborhood Hits	17
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

APC10_MOUSE
NC score	0.199611 (rank : 59)	θ value	0.00102713 (rank : 70)
Query Neighborhood Hits	163	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

SAV1_MOUSE
NC score	0.179896 (rank : 60)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.179683 (rank : 61)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	163	Target Neighborhood Hits	51	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SQSTM_MOUSE
NC score	0.175867 (rank : 62)	θ value	4.1701e-05 (rank : 64)
Query Neighborhood Hits	163	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

SQSTM_HUMAN
NC score	0.175540 (rank : 63)	θ value	5.44631e-05 (rank : 65)
Query Neighborhood Hits	163	Target Neighborhood Hits	61	Shared Neighborhood Hits	21
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

PINL_HUMAN
NC score	0.167751 (rank : 64)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	163	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

NEK9_MOUSE
NC score	0.160490 (rank : 65)	θ value	9.8567e-31 (rank : 20)
Query Neighborhood Hits	163	Target Neighborhood Hits	890	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK9_HUMAN
NC score	0.158507 (rank : 66)	θ value	5.77852e-31 (rank : 19)
Query Neighborhood Hits	163	Target Neighborhood Hits	900	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

CYB5_HUMAN
NC score	0.154524 (rank : 67)	θ value	0.000270298 (rank : 66)
Query Neighborhood Hits	163	Target Neighborhood Hits	10	Shared Neighborhood Hits	8
SwissProt Accessions	P00167	Gene names	CYB5
Domain Architecture
Description	Cytochrome b5.

NEK8_HUMAN
NC score	0.152896 (rank : 68)	θ value	5.96599e-36 (rank : 6)
Query Neighborhood Hits	163	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
NC score	0.152153 (rank : 69)	θ value	8.06329e-33 (rank : 11)
Query Neighborhood Hits	163	Target Neighborhood Hits	872	Shared Neighborhood Hits	32
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

WWC1_MOUSE
NC score	0.149512 (rank : 70)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWC1_HUMAN
NC score	0.148642 (rank : 71)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	163	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

CYB5B_MOUSE
NC score	0.146843 (rank : 72)	θ value	0.000602161 (rank : 69)
Query Neighborhood Hits	163	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CQX2, Q9D1M6, Q9D8R3	Gene names	Cyb5b, Cyb5m
Domain Architecture	No domain graphic available
Description	Cytochrome b5 type B precursor (Cytochrome b5 outer mitochondrial membrane isoform).

PIN1_HUMAN
NC score	0.140901 (rank : 73)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

ZSWM2_HUMAN
NC score	0.139903 (rank : 74)	θ value	3.19293e-05 (rank : 63)
Query Neighborhood Hits	163	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q8NEG5	Gene names	ZSWIM2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

PIN1_MOUSE
NC score	0.139848 (rank : 75)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	163	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWOX_HUMAN
NC score	0.139587 (rank : 76)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	163	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

CYB5B_HUMAN
NC score	0.139260 (rank : 77)	θ value	0.00175202 (rank : 71)
Query Neighborhood Hits	163	Target Neighborhood Hits	15	Shared Neighborhood Hits	8
SwissProt Accessions	O43169, Q96CC3, Q9BT35	Gene names	CYB5B, CYB5M, OMB5
Domain Architecture
Description	Cytochrome b5 type B precursor (Cytochrome b5 outer mitochondrial membrane isoform).

WWOX_MOUSE
NC score	0.138340 (rank : 78)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	163	Target Neighborhood Hits	118	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

CYB5_MOUSE
NC score	0.131806 (rank : 79)	θ value	0.00665767 (rank : 74)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	P56395	Gene names	Cyb5
Domain Architecture
Description	Cytochrome b5.

BAG3_HUMAN
NC score	0.131202 (rank : 80)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	163	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

ZSWM2_MOUSE
NC score	0.126554 (rank : 81)	θ value	0.00035302 (rank : 67)
Query Neighborhood Hits	163	Target Neighborhood Hits	132	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D9X6	Gene names	Zswim2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

WWTR1_MOUSE
NC score	0.122090 (rank : 82)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	163	Target Neighborhood Hits	54	Shared Neighborhood Hits	15
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.119540 (rank : 83)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	163	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.116711 (rank : 84)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	163	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

MIB2_HUMAN
NC score	0.114879 (rank : 85)	θ value	4.59992e-12 (rank : 57)
Query Neighborhood Hits	163	Target Neighborhood Hits	438	Shared Neighborhood Hits	24
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.114574 (rank : 86)	θ value	1.133e-10 (rank : 58)
Query Neighborhood Hits	163	Target Neighborhood Hits	409	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

DTNA_MOUSE
NC score	0.111738 (rank : 87)	θ value	0.00298849 (rank : 73)
Query Neighborhood Hits	163	Target Neighborhood Hits	264	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

BAG3_MOUSE
NC score	0.110706 (rank : 88)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	163	Target Neighborhood Hits	513	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

DTNA_HUMAN
NC score	0.108650 (rank : 89)	θ value	0.00228821 (rank : 72)
Query Neighborhood Hits	163	Target Neighborhood Hits	295	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

DTNB_HUMAN
NC score	0.107385 (rank : 90)	θ value	0.00665767 (rank : 75)
Query Neighborhood Hits	163	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	O60941, O43782, O60881, O75538, Q9UE14, Q9UE15, Q9UE16	Gene names	DTNB
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B).

DRP2_HUMAN
NC score	0.106246 (rank : 91)	θ value	0.0252991 (rank : 78)
Query Neighborhood Hits	163	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

DTNB_MOUSE
NC score	0.103785 (rank : 92)	θ value	0.00869519 (rank : 76)
Query Neighborhood Hits	163	Target Neighborhood Hits	263	Shared Neighborhood Hits	20
SwissProt Accessions	O70585, O70563, Q9CTZ1	Gene names	Dtnb
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B) (MDTN-B).

MIB1_MOUSE
NC score	0.102342 (rank : 93)	θ value	1.9326e-10 (rank : 61)
Query Neighborhood Hits	163	Target Neighborhood Hits	471	Shared Neighborhood Hits	26
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.102191 (rank : 94)	θ value	1.9326e-10 (rank : 60)
Query Neighborhood Hits	163	Target Neighborhood Hits	470	Shared Neighborhood Hits	26
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MAGI2_MOUSE
NC score	0.099278 (rank : 95)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	163	Target Neighborhood Hits	370	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PKHA5_HUMAN
NC score	0.098118 (rank : 96)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	163	Target Neighborhood Hits	455	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

MAGI2_HUMAN
NC score	0.092341 (rank : 97)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	163	Target Neighborhood Hits	373	Shared Neighborhood Hits	20
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_MOUSE
NC score	0.092029 (rank : 98)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	163	Target Neighborhood Hits	403	Shared Neighborhood Hits	20
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.091548 (rank : 99)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	163	Target Neighborhood Hits	388	Shared Neighborhood Hits	20
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GAS7_HUMAN
NC score	0.087499 (rank : 100)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	163	Target Neighborhood Hits	258	Shared Neighborhood Hits	15
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.087349 (rank : 101)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	163	Target Neighborhood Hits	259	Shared Neighborhood Hits	15
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

NBR1_HUMAN
NC score	0.080307 (rank : 102)	θ value	0.0961366 (rank : 81)
Query Neighborhood Hits	163	Target Neighborhood Hits	105	Shared Neighborhood Hits	20
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

PRP40_MOUSE
NC score	0.075263 (rank : 103)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	163	Target Neighborhood Hits	447	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

PRP40_HUMAN
NC score	0.074043 (rank : 104)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	163	Target Neighborhood Hits	442	Shared Neighborhood Hits	21
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

APBB2_HUMAN
NC score	0.058796 (rank : 105)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	163	Target Neighborhood Hits	96	Shared Neighborhood Hits	15
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

NBR1_MOUSE
NC score	0.058424 (rank : 106)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	163	Target Neighborhood Hits	116	Shared Neighborhood Hits	17
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

ABTB2_MOUSE
NC score	0.057114 (rank : 107)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	163	Target Neighborhood Hits	414	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

APBB2_MOUSE
NC score	0.056604 (rank : 108)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	163	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

STXB4_HUMAN
NC score	0.054979 (rank : 109)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	163	Target Neighborhood Hits	616	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

ABTB2_HUMAN
NC score	0.054714 (rank : 110)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	163	Target Neighborhood Hits	391	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

STXB4_MOUSE
NC score	0.054250 (rank : 111)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	163	Target Neighborhood Hits	629	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SUOX_HUMAN
NC score	0.053617 (rank : 112)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	163	Target Neighborhood Hits	13	Shared Neighborhood Hits	8
SwissProt Accessions	P51687	Gene names	SUOX
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

SAKS1_HUMAN
NC score	0.047166 (rank : 113)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	163	Target Neighborhood Hits	202	Shared Neighborhood Hits	8
SwissProt Accessions	Q04323, Q9BV93, Q9BVV5	Gene names	SAKS1
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein).

EP300_HUMAN
NC score	0.046325 (rank : 114)	θ value	0.0961366 (rank : 80)
Query Neighborhood Hits	163	Target Neighborhood Hits	821	Shared Neighborhood Hits	21
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

CBP_HUMAN
NC score	0.046181 (rank : 115)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	163	Target Neighborhood Hits	941	Shared Neighborhood Hits	27
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SAKS1_MOUSE
NC score	0.046073 (rank : 116)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	163	Target Neighborhood Hits	208	Shared Neighborhood Hits	8
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

HEMK1_MOUSE
NC score	0.043782 (rank : 117)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q921L7	Gene names	Hemk1
Domain Architecture	No domain graphic available
Description	HemK methyltransferase family member 1 (EC 2.1.1.-).

SUOX_MOUSE
NC score	0.043202 (rank : 118)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	163	Target Neighborhood Hits	11	Shared Neighborhood Hits	8
SwissProt Accessions	Q8R086	Gene names	Suox
Domain Architecture
Description	Sulfite oxidase, mitochondrial precursor (EC 1.8.3.1).

DMD_HUMAN
NC score	0.042947 (rank : 119)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	163	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

CBP_MOUSE
NC score	0.042553 (rank : 120)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	163	Target Neighborhood Hits	1051	Shared Neighborhood Hits	26
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

UTRO_HUMAN
NC score	0.041256 (rank : 121)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	163	Target Neighborhood Hits	960	Shared Neighborhood Hits	34
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

DMD_MOUSE
NC score	0.038948 (rank : 122)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	163	Target Neighborhood Hits	1111	Shared Neighborhood Hits	31
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

XRCC4_MOUSE
NC score	0.035672 (rank : 123)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	163	Target Neighborhood Hits	104	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T3, Q8BKC9, Q8BU02, Q9D6U6	Gene names	Xrcc4
Domain Architecture
Description	DNA-repair protein XRCC4 (X-ray repair cross-complementing protein 4).

CN046_HUMAN
NC score	0.029161 (rank : 124)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	163	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q52LA3	Gene names	C14orf46
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf46.

CN046_MOUSE
NC score	0.029161 (rank : 125)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	163	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CD94	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf46 homolog.

MPP8_HUMAN
NC score	0.027765 (rank : 126)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	163	Target Neighborhood Hits	948	Shared Neighborhood Hits	17
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

ERCC5_MOUSE
NC score	0.024925 (rank : 127)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	163	Target Neighborhood Hits	206	Shared Neighborhood Hits	10
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

NACAM_MOUSE
NC score	0.024024 (rank : 128)	θ value	0.62314 (rank : 88)
Query Neighborhood Hits	163	Target Neighborhood Hits	1866	Shared Neighborhood Hits	28
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GON4L_HUMAN
NC score	0.022498 (rank : 129)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	163	Target Neighborhood Hits	555	Shared Neighborhood Hits	14
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

ANK3_HUMAN
NC score	0.022120 (rank : 130)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	163	Target Neighborhood Hits	853	Shared Neighborhood Hits	22
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

SMG1_MOUSE
NC score	0.021788 (rank : 131)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	163	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.021493 (rank : 132)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	163	Target Neighborhood Hits	231	Shared Neighborhood Hits	6
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

TOP2A_HUMAN
NC score	0.020384 (rank : 133)	θ value	0.62314 (rank : 89)
Query Neighborhood Hits	163	Target Neighborhood Hits	135	Shared Neighborhood Hits	6
SwissProt Accessions	P11388, Q71UN1, Q9HB24, Q9HB25, Q9HB26, Q9UP44, Q9UQP9	Gene names	TOP2A, TOP2
Domain Architecture
Description	DNA topoisomerase 2-alpha (EC 5.99.1.3) (DNA topoisomerase II, alpha isozyme).

MFGM_MOUSE
NC score	0.019637 (rank : 134)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	163	Target Neighborhood Hits	233	Shared Neighborhood Hits	4
SwissProt Accessions	P21956, P97800, Q3TBN5, Q9R1X9, Q9WTS3	Gene names	Mfge8
Domain Architecture
Description	Lactadherin precursor (Milk fat globule-EGF factor 8) (MFG-E8) (MFGM) (Sperm surface protein SP47) (MP47).

CRLF2_MOUSE
NC score	0.019459 (rank : 135)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	163	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CII9, Q9CRJ6, Q9JIE7, Q9JIQ7, Q9JJH8, Q9JMD5	Gene names	Crlf2, Crlm2, Tpte2, Tslpr
Domain Architecture
Description	Cytokine receptor-like factor 2 precursor (Type I cytokine receptor delta 1) (Cytokine receptor-like molecule 2) (CRLM-2) (Thymic stromal lymphopoietin protein receptor) (TSLPR).

PDZD8_HUMAN
NC score	0.019443 (rank : 136)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	163	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

LRC25_HUMAN
NC score	0.018277 (rank : 137)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	163	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N386, Q8N9A5	Gene names	LRRC25, MAPA
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 25 precursor (Monocyte and plasmacytoid-activated protein).

UBP5_MOUSE
NC score	0.018085 (rank : 138)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	163	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	P56399	Gene names	Usp5, Isot
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

MAK_MOUSE
NC score	0.017861 (rank : 139)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	163	Target Neighborhood Hits	873	Shared Neighborhood Hits	11
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

UBP5_HUMAN
NC score	0.017741 (rank : 140)	θ value	8.99809 (rank : 162)
Query Neighborhood Hits	163	Target Neighborhood Hits	109	Shared Neighborhood Hits	8
SwissProt Accessions	P45974, Q96J22	Gene names	USP5, ISOT
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.1.2.15) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5) (Deubiquitinating enzyme 5) (Isopeptidase T).

NNTM_MOUSE
NC score	0.017586 (rank : 141)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	163	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

SLAF7_HUMAN
NC score	0.016290 (rank : 142)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	163	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NQ25, Q8N6Y8, Q8ND32, Q9NY08, Q9NY23	Gene names	SLAMF7, CS1
Domain Architecture	No domain graphic available
Description	SLAM family member 7 precursor (CD2-like receptor activating cytotoxic cells) (CRACC) (Protein 19A) (CD2 subset 1) (Novel Ly9) (Membrane protein FOAP-12) (CD319 antigen).

HIPK1_HUMAN
NC score	0.015466 (rank : 143)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	163	Target Neighborhood Hits	843	Shared Neighborhood Hits	10
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

CN155_HUMAN
NC score	0.015388 (rank : 144)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	163	Target Neighborhood Hits	385	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

DICER_HUMAN
NC score	0.015036 (rank : 145)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	163	Target Neighborhood Hits	126	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.014926 (rank : 146)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	163	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

PHF22_HUMAN
NC score	0.014900 (rank : 147)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96CB8, Q9HD71	Gene names	INTS12, PHF22
Domain Architecture	No domain graphic available
Description	Integrator complex subunit 12 (PHD finger protein 22).

TTBK2_MOUSE
NC score	0.014835 (rank : 148)	θ value	3.0926 (rank : 113)
Query Neighborhood Hits	163	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

KPCE_HUMAN
NC score	0.013951 (rank : 149)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	163	Target Neighborhood Hits	906	Shared Neighborhood Hits	14
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MFN2_MOUSE
NC score	0.012544 (rank : 150)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	163	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q80U63, Q3V3B8, Q80WP4, Q80XK3, Q8BHF0, Q8BKV5, Q8R535, Q923X2	Gene names	Mfn2, Kiaa0214, Marf
Domain Architecture
Description	Transmembrane GTPase MFN2 (EC 3.6.5.-) (Mitofusin-2) (Hypertension- related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein).

HSH2D_MOUSE
NC score	0.011374 (rank : 151)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	163	Target Neighborhood Hits	124	Shared Neighborhood Hits	3
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ABCAD_HUMAN
NC score	0.009788 (rank : 152)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	163	Target Neighborhood Hits	207	Shared Neighborhood Hits	5
SwissProt Accessions	Q86UQ4, Q6ZTT7, Q86WI2, Q8N248	Gene names	ABCA13
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 13.

POZP3_HUMAN
NC score	0.009420 (rank : 153)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	163	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PJE2, Q12903, Q9BWB4	Gene names	POMZP3
Domain Architecture	No domain graphic available
Description	POM121 and ZP3 fusion protein (POM-ZP3).

LRFN4_HUMAN
NC score	0.009347 (rank : 154)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	163	Target Neighborhood Hits	462	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

MYST4_HUMAN
NC score	0.009099 (rank : 155)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	163	Target Neighborhood Hits	671	Shared Neighborhood Hits	16
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

SMRC2_MOUSE
NC score	0.008915 (rank : 156)	θ value	8.99809 (rank : 159)
Query Neighborhood Hits	163	Target Neighborhood Hits	487	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

MYST3_HUMAN
NC score	0.008645 (rank : 157)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	163	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

CSAD_MOUSE
NC score	0.008412 (rank : 158)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	163	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DBE0	Gene names	Csad
Domain Architecture
Description	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Sulfinoalanine decarboxylase) (Cysteine-sulfinate decarboxylase).

CSAD_HUMAN
NC score	0.008368 (rank : 159)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	163	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y600, Q9UNJ5, Q9Y601	Gene names	CSAD, CSD
Domain Architecture
Description	Cysteine sulfinic acid decarboxylase (EC 4.1.1.29) (Sulfinoalanine decarboxylase) (Cysteine-sulfinate decarboxylase).

TLN1_HUMAN
NC score	0.007660 (rank : 160)	θ value	3.0926 (rank : 112)
Query Neighborhood Hits	163	Target Neighborhood Hits	218	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

SMRC2_HUMAN
NC score	0.007282 (rank : 161)	θ value	8.99809 (rank : 158)
Query Neighborhood Hits	163	Target Neighborhood Hits	499	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SRBP1_HUMAN
NC score	0.006967 (rank : 162)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

GP110_MOUSE
NC score	0.006623 (rank : 163)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	163	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VEC3, Q8BMV8	Gene names	Gpr110
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 110 precursor.

TLN1_MOUSE
NC score	0.006258 (rank : 164)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	163	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

WDR67_HUMAN
NC score	0.006000 (rank : 165)	θ value	3.0926 (rank : 114)
Query Neighborhood Hits	163	Target Neighborhood Hits	782	Shared Neighborhood Hits	9
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

STRAP_HUMAN
NC score	0.005801 (rank : 166)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	163	Target Neighborhood Hits	272	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3F4, Q9UQC8	Gene names	STRAP, MAWD, UNRIP
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein) (WD-40 repeat protein PT-WD) (MAP activator with WD repeats).

STRAP_MOUSE
NC score	0.005660 (rank : 167)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	163	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z1Z2	Gene names	Strap, Unrip
Domain Architecture
Description	Serine-threonine kinase receptor-associated protein (UNR-interacting protein).

S39A4_MOUSE
NC score	0.005573 (rank : 168)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	163	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q78IQ7, Q8CHL4	Gene names	Slc39a4, Zip4
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP4 precursor (Solute carrier family 39 member 4) (Activated in W/Wv mouse stomach 2) (mAWMS2).

STX18_HUMAN
NC score	0.005364 (rank : 169)	θ value	8.99809 (rank : 160)
Query Neighborhood Hits	163	Target Neighborhood Hits	225	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

DDX27_HUMAN
NC score	0.005125 (rank : 170)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	163	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DUS4_MOUSE
NC score	0.004970 (rank : 171)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	163	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFV3	Gene names	Dusp4
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16).

DUS4_HUMAN
NC score	0.004933 (rank : 172)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	163	Target Neighborhood Hits	77	Shared Neighborhood Hits	4
SwissProt Accessions	Q13115, Q13524	Gene names	DUSP4, MKP2, VH2
Domain Architecture
Description	Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2) (Dual specificity protein phosphatase hVH2).

NTRI_MOUSE
NC score	0.004454 (rank : 173)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	163	Target Neighborhood Hits	342	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

SYNJ2_MOUSE
NC score	0.004354 (rank : 174)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	163	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

SO3A1_HUMAN
NC score	0.004304 (rank : 175)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	163	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UIG8, Q9BW73, Q9GZV2	Gene names	SLCO3A1, OATPD, SLC21A11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (Organic anion transporter polypeptide-related protein 3) (OATP-RP3) (OATPRP3) (PGE1 transporter).

SO3A1_MOUSE
NC score	0.004295 (rank : 176)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	163	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3L5, Q9CTV3, Q9JKV0	Gene names	Slco3a1, Oatpd, Slc21a11
Domain Architecture
Description	Solute carrier organic anion transporter family member 3A1 (Solute carrier family 21 member 11) (Sodium-independent organic anion transporter D) (Organic anion-transporting polypeptide D) (OATP-D) (MJAM).

TNR1A_HUMAN
NC score	0.003877 (rank : 177)	θ value	8.99809 (rank : 161)
Query Neighborhood Hits	163	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

NTRI_HUMAN
NC score	0.003729 (rank : 178)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	163	Target Neighborhood Hits	344	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

ADAM9_MOUSE
NC score	0.003459 (rank : 179)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	163	Target Neighborhood Hits	325	Shared Neighborhood Hits	5
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

U3IP2_HUMAN
NC score	0.003383 (rank : 180)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	163	Target Neighborhood Hits	307	Shared Neighborhood Hits	8
SwissProt Accessions	O43818, Q8IZ30	Gene names	RNU3IP2, U355K
Domain Architecture
Description	U3 small nucleolar RNA-interacting protein 2 (U3 small nucleolar ribonucleoprotein-associated 55 kDa protein) (U3 snoRNP-associated 55 kDa protein) (U3-55K).

PK1IP_MOUSE
NC score	0.003311 (rank : 181)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	163	Target Neighborhood Hits	313	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

DDX27_MOUSE
NC score	0.003215 (rank : 182)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	163	Target Neighborhood Hits	174	Shared Neighborhood Hits	9
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

ITA5_HUMAN
NC score	0.003111 (rank : 183)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	163	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P08648, Q96HA5	Gene names	ITGA5, FNRA
Domain Architecture
Description	Integrin alpha-5 precursor (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD49e antigen) [Contains: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain].

SM1L2_MOUSE
NC score	0.003013 (rank : 184)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	163	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

ERCC6_HUMAN
NC score	0.002990 (rank : 185)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	163	Target Neighborhood Hits	247	Shared Neighborhood Hits	5
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

SMAL1_MOUSE
NC score	0.002805 (rank : 186)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	163	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

RN168_MOUSE
NC score	0.002711 (rank : 187)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	163	Target Neighborhood Hits	440	Shared Neighborhood Hits	7
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

MPDZ_HUMAN
NC score	0.001158 (rank : 188)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	163	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

KIF17_HUMAN
NC score	-0.000455 (rank : 189)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	163	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

SLIK3_MOUSE
NC score	-0.000638 (rank : 190)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	163	Target Neighborhood Hits	308	Shared Neighborhood Hits	4
SwissProt Accessions	Q810B9	Gene names	Slitrk3
Domain Architecture
Description	SLIT and NTRK-like protein 3 precursor.

FBN1_HUMAN
NC score	-0.002408 (rank : 191)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	163	Target Neighborhood Hits	557	Shared Neighborhood Hits	5
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

ZNF85_HUMAN
NC score	-0.004004 (rank : 192)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	163	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	Q03923	Gene names	ZNF85
Domain Architecture
Description	Zinc finger protein 85 (Zinc finger protein HPF4) (HTF1).

ZN431_HUMAN
NC score	-0.005269 (rank : 193)	θ value	5.27518 (rank : 132)
Query Neighborhood Hits	163	Target Neighborhood Hits	765	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TF32, Q8IWC4	Gene names	ZNF431, KIAA1969
Domain Architecture
Description	Zinc finger protein 431.