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Network neighborhood for query Sequence : NNTM_MOUSE

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NNTM_MOUSE
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NNTM_HUMAN
θ value	0 (rank : 1)	NC score	0.998796 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q13423, Q16796, Q8N3V4	Gene names	NNT
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

NNTM_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

GTR4_MOUSE
θ value	0.62314 (rank : 3)	NC score	0.038183 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P14142, Q9JJN9	Gene names	Slc2a4, Glut-4, Glut4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GT2).

GTR4_HUMAN
θ value	0.813845 (rank : 4)	NC score	0.036546 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P14672	Gene names	SLC2A4, GLUT4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive).

TMM65_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.091210 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PI78, Q8N5G8, Q8WVK5	Gene names	TMEM65
Domain Architecture	No domain graphic available
Description	Transmembrane protein 65.

S23A2_HUMAN
θ value	2.36792 (rank : 6)	NC score	0.043716 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGH3, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85	Gene names	SLC23A2, KIAA0238, NBTL1, SVCT2, YSPL2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2) (Nucleobase transporter-like 1 protein).

DHSO_HUMAN
θ value	3.0926 (rank : 7)	NC score	0.037906 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

S23A2_MOUSE
θ value	3.0926 (rank : 8)	NC score	0.041302 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR4, Q8C327, Q9JM78	Gene names	Slc23a2, Kiaa0238, Svct2, Yspl2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (mSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2).

BRDT_HUMAN
θ value	4.03905 (rank : 9)	NC score	0.017705 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

ETFD_MOUSE
θ value	4.03905 (rank : 10)	NC score	0.043819 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q921G7, Q3U7K2, Q8BK82, Q9DCT9	Gene names	Etfdh
Domain Architecture	No domain graphic available
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

HERC2_HUMAN
θ value	4.03905 (rank : 11)	NC score	0.017586 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	4.03905 (rank : 12)	NC score	0.017584 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

MESD1_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.022373 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERE8, Q542D0	Gene names	Mesdc1
Domain Architecture	No domain graphic available
Description	Mesoderm development candidate 1.

C1TC_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.026272 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.026423 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

OPLA_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.034763 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

CJ012_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.025422 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	467	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

ETFD_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.035496 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q16134, Q7Z347	Gene names	ETFDH
Domain Architecture
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

SIRT5_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.025302 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

XKR5_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.014400 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.

OPLA_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.028855 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

Hits sorted by NC score

NNTM_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

NNTM_HUMAN
NC score	0.998796 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	15
SwissProt Accessions	Q13423, Q16796, Q8N3V4	Gene names	NNT
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

TMM65_HUMAN
NC score	0.091210 (rank : 3)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PI78, Q8N5G8, Q8WVK5	Gene names	TMEM65
Domain Architecture	No domain graphic available
Description	Transmembrane protein 65.

ETFD_MOUSE
NC score	0.043819 (rank : 4)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q921G7, Q3U7K2, Q8BK82, Q9DCT9	Gene names	Etfdh
Domain Architecture	No domain graphic available
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

S23A2_HUMAN
NC score	0.043716 (rank : 5)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGH3, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85	Gene names	SLC23A2, KIAA0238, NBTL1, SVCT2, YSPL2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2) (Nucleobase transporter-like 1 protein).

S23A2_MOUSE
NC score	0.041302 (rank : 6)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR4, Q8C327, Q9JM78	Gene names	Slc23a2, Kiaa0238, Svct2, Yspl2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (mSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2).

GTR4_MOUSE
NC score	0.038183 (rank : 7)	θ value	0.62314 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P14142, Q9JJN9	Gene names	Slc2a4, Glut-4, Glut4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GT2).

DHSO_HUMAN
NC score	0.037906 (rank : 8)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

GTR4_HUMAN
NC score	0.036546 (rank : 9)	θ value	0.813845 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P14672	Gene names	SLC2A4, GLUT4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive).

ETFD_HUMAN
NC score	0.035496 (rank : 10)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q16134, Q7Z347	Gene names	ETFDH
Domain Architecture
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

OPLA_MOUSE
NC score	0.034763 (rank : 11)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

OPLA_HUMAN
NC score	0.028855 (rank : 12)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

C1TC_MOUSE
NC score	0.026423 (rank : 13)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_HUMAN
NC score	0.026272 (rank : 14)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

CJ012_HUMAN
NC score	0.025422 (rank : 15)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	467	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

SIRT5_HUMAN
NC score	0.025302 (rank : 16)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

MESD1_MOUSE
NC score	0.022373 (rank : 17)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERE8, Q542D0	Gene names	Mesdc1
Domain Architecture	No domain graphic available
Description	Mesoderm development candidate 1.

BRDT_HUMAN
NC score	0.017705 (rank : 18)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

HERC2_HUMAN
NC score	0.017586 (rank : 19)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.017584 (rank : 20)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

XKR5_MOUSE
NC score	0.014400 (rank : 21)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	89	Shared Neighborhood Hits	2
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.