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Network neighborhood for query Sequence : NNTM_HUMAN

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NNTM_HUMAN
SwissProt Accessions	Q13423, Q16796, Q8N3V4	Gene names	NNT
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NNTM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q13423, Q16796, Q8N3V4	Gene names	NNT
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

NNTM_MOUSE
θ value	0 (rank : 2)	NC score	0.998796 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

TMM65_HUMAN
θ value	0.0736092 (rank : 3)	NC score	0.107419 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PI78, Q8N5G8, Q8WVK5	Gene names	TMEM65
Domain Architecture	No domain graphic available
Description	Transmembrane protein 65.

GTR4_MOUSE
θ value	1.38821 (rank : 4)	NC score	0.034535 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P14142, Q9JJN9	Gene names	Slc2a4, Glut-4, Glut4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GT2).

GTR4_HUMAN
θ value	1.81305 (rank : 5)	NC score	0.032896 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P14672	Gene names	SLC2A4, GLUT4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive).

S23A2_HUMAN
θ value	2.36792 (rank : 6)	NC score	0.043725 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGH3, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85	Gene names	SLC23A2, KIAA0238, NBTL1, SVCT2, YSPL2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2) (Nucleobase transporter-like 1 protein).

S23A2_MOUSE
θ value	3.0926 (rank : 7)	NC score	0.041311 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR4, Q8C327, Q9JM78	Gene names	Slc23a2, Kiaa0238, Svct2, Yspl2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (mSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2).

DHSO_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.036622 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

ETFD_MOUSE
θ value	4.03905 (rank : 9)	NC score	0.042334 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q921G7, Q3U7K2, Q8BK82, Q9DCT9	Gene names	Etfdh
Domain Architecture	No domain graphic available
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

BRDT_HUMAN
θ value	5.27518 (rank : 10)	NC score	0.016886 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

CJ012_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.027442 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	467	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

MINT_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.009500 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	1514	Shared Neighborhood Hits	3
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

OPLA_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.034770 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

SIRT5_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.026520 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

ETFD_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.033954 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q16134, Q7Z347	Gene names	ETFDH
Domain Architecture
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

JAD1D_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.006399 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	147	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

OPLA_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.028861 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

Hits sorted by NC score

NNTM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	17
SwissProt Accessions	Q13423, Q16796, Q8N3V4	Gene names	NNT
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

NNTM_MOUSE
NC score	0.998796 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

TMM65_HUMAN
NC score	0.107419 (rank : 3)	θ value	0.0736092 (rank : 3)
Query Neighborhood Hits	17	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PI78, Q8N5G8, Q8WVK5	Gene names	TMEM65
Domain Architecture	No domain graphic available
Description	Transmembrane protein 65.

S23A2_HUMAN
NC score	0.043725 (rank : 4)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	17	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGH3, Q8WWR4, Q92512, Q96D54, Q9UNU1, Q9UP85	Gene names	SLC23A2, KIAA0238, NBTL1, SVCT2, YSPL2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (hSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2) (Nucleobase transporter-like 1 protein).

ETFD_MOUSE
NC score	0.042334 (rank : 5)	θ value	4.03905 (rank : 9)
Query Neighborhood Hits	17	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q921G7, Q3U7K2, Q8BK82, Q9DCT9	Gene names	Etfdh
Domain Architecture	No domain graphic available
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

S23A2_MOUSE
NC score	0.041311 (rank : 6)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	17	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPR4, Q8C327, Q9JM78	Gene names	Slc23a2, Kiaa0238, Svct2, Yspl2
Domain Architecture
Description	Solute carrier family 23 member 2 (Sodium-dependent vitamin C transporter 2) (mSVCT2) (Na(+)/L-ascorbic acid transporter 2) (Yolk sac permease-like molecule 2).

DHSO_HUMAN
NC score	0.036622 (rank : 7)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	17	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

OPLA_MOUSE
NC score	0.034770 (rank : 8)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	17	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

GTR4_MOUSE
NC score	0.034535 (rank : 9)	θ value	1.38821 (rank : 4)
Query Neighborhood Hits	17	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	P14142, Q9JJN9	Gene names	Slc2a4, Glut-4, Glut4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GT2).

ETFD_HUMAN
NC score	0.033954 (rank : 10)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	17	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	Q16134, Q7Z347	Gene names	ETFDH
Domain Architecture
Description	Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial precursor (EC 1.5.5.1) (ETF-QO) (ETF-ubiquinone oxidoreductase) (ETF dehydrogenase) (Electron-transferring- flavoprotein dehydrogenase).

GTR4_HUMAN
NC score	0.032896 (rank : 11)	θ value	1.81305 (rank : 5)
Query Neighborhood Hits	17	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	P14672	Gene names	SLC2A4, GLUT4
Domain Architecture
Description	Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive).

OPLA_HUMAN
NC score	0.028861 (rank : 12)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

CJ012_HUMAN
NC score	0.027442 (rank : 13)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	17	Target Neighborhood Hits	467	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

SIRT5_HUMAN
NC score	0.026520 (rank : 14)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	17	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXA8, Q9Y6E6	Gene names	SIRT5, SIR2L5
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-5 (EC 3.5.1.-) (SIR2-like protein 5).

BRDT_HUMAN
NC score	0.016886 (rank : 15)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	17	Target Neighborhood Hits	280	Shared Neighborhood Hits	3
SwissProt Accessions	Q58F21, O14789, Q6P5T1, Q7Z4A6, Q8IWI6	Gene names	BRDT
Domain Architecture	No domain graphic available
Description	Bromodomain testis-specific protein (RING3-like protein).

MINT_MOUSE
NC score	0.009500 (rank : 16)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	17	Target Neighborhood Hits	1514	Shared Neighborhood Hits	3
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

JAD1D_HUMAN
NC score	0.006399 (rank : 17)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	17	Target Neighborhood Hits	147	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).