Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : C1TC_HUMAN

For an explanation of this page, click here

C1TC_HUMAN
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

C1TC_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
θ value	0 (rank : 2)	NC score	0.998363 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

MTDC_MOUSE
θ value	7.75577e-52 (rank : 3)	NC score	0.844634 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
θ value	1.11993e-50 (rank : 4)	NC score	0.842072 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

PTPRJ_MOUSE
θ value	1.38821 (rank : 5)	NC score	0.014709 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

SPTN5_HUMAN
θ value	1.38821 (rank : 6)	NC score	0.016652 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

CR034_MOUSE
θ value	3.0926 (rank : 7)	NC score	0.011420 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	643	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

TRI10_HUMAN
θ value	4.03905 (rank : 8)	NC score	0.010415 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

CRYM_MOUSE
θ value	5.27518 (rank : 9)	NC score	0.021284 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O54983	Gene names	Crym
Domain Architecture
Description	Mu-crystallin homolog.

NNTM_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.026272 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

YMEL1_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.011656 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

YMEL1_MOUSE
θ value	5.27518 (rank : 12)	NC score	0.011444 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

DDX27_MOUSE
θ value	6.88961 (rank : 13)	NC score	0.004510 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

ITAL_MOUSE
θ value	6.88961 (rank : 14)	NC score	0.010699 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P24063	Gene names	Itgal, Lfa-1, Ly-15
Domain Architecture
Description	Integrin alpha-L precursor (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen Ly-15) (CD11a antigen).

PK3C3_HUMAN
θ value	6.88961 (rank : 15)	NC score	0.013574 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	6.88961 (rank : 16)	NC score	0.013582 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

RGMC_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.011792 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ32, Q8CEU7, Q8K1D4, Q9D741	Gene names	Hfe2, Rgmc
Domain Architecture	No domain graphic available
Description	Hemojuvelin precursor (Hemochromatosis type 2 protein homolog) (RGM domain family member C).

EDEM1_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.008617 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

KI21A_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.001593 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1543	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

Hits sorted by NC score

C1TC_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
NC score	0.998363 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	16	Shared Neighborhood Hits	9
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

MTDC_MOUSE
NC score	0.844634 (rank : 3)	θ value	7.75577e-52 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
NC score	0.842072 (rank : 4)	θ value	1.11993e-50 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

NNTM_MOUSE
NC score	0.026272 (rank : 5)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

CRYM_MOUSE
NC score	0.021284 (rank : 6)	θ value	5.27518 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	O54983	Gene names	Crym
Domain Architecture
Description	Mu-crystallin homolog.

SPTN5_HUMAN
NC score	0.016652 (rank : 7)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	674	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

PTPRJ_MOUSE
NC score	0.014709 (rank : 8)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

PK3C3_MOUSE
NC score	0.013582 (rank : 9)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.013574 (rank : 10)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

RGMC_MOUSE
NC score	0.011792 (rank : 11)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQ32, Q8CEU7, Q8K1D4, Q9D741	Gene names	Hfe2, Rgmc
Domain Architecture	No domain graphic available
Description	Hemojuvelin precursor (Hemochromatosis type 2 protein homolog) (RGM domain family member C).

YMEL1_HUMAN
NC score	0.011656 (rank : 12)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

YMEL1_MOUSE
NC score	0.011444 (rank : 13)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

CR034_MOUSE
NC score	0.011420 (rank : 14)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	643	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

ITAL_MOUSE
NC score	0.010699 (rank : 15)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P24063	Gene names	Itgal, Lfa-1, Ly-15
Domain Architecture
Description	Integrin alpha-L precursor (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen Ly-15) (CD11a antigen).

TRI10_HUMAN
NC score	0.010415 (rank : 16)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

EDEM1_HUMAN
NC score	0.008617 (rank : 17)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

DDX27_MOUSE
NC score	0.004510 (rank : 18)	θ value	6.88961 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

KI21A_HUMAN
NC score	0.001593 (rank : 19)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1543	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).