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Network neighborhood for query Sequence : MTDC_MOUSE

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MTDC_MOUSE
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MTDC_MOUSE
θ value	1.15296e-180 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
θ value	8.57033e-168 (rank : 2)	NC score	0.999583 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

C1TC_HUMAN
θ value	7.75577e-52 (rank : 3)	NC score	0.844634 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
θ value	1.04822e-48 (rank : 4)	NC score	0.839083 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

DP13B_HUMAN
θ value	0.163984 (rank : 5)	NC score	0.072197 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	2.36792 (rank : 6)	NC score	0.057884 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

TBCD4_HUMAN
θ value	2.36792 (rank : 7)	NC score	0.032452 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TBCD4_MOUSE
θ value	4.03905 (rank : 8)	NC score	0.029989 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

PK3CB_HUMAN
θ value	8.99809 (rank : 9)	NC score	0.010135 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	8.99809 (rank : 10)	NC score	0.010111 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

Hits sorted by NC score

MTDC_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.15296e-180 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
NC score	0.999583 (rank : 2)	θ value	8.57033e-168 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

C1TC_HUMAN
NC score	0.844634 (rank : 3)	θ value	7.75577e-52 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
NC score	0.839083 (rank : 4)	θ value	1.04822e-48 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

DP13B_HUMAN
NC score	0.072197 (rank : 5)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
NC score	0.057884 (rank : 6)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

TBCD4_HUMAN
NC score	0.032452 (rank : 7)	θ value	2.36792 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TBCD4_MOUSE
NC score	0.029989 (rank : 8)	θ value	4.03905 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	276	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

PK3CB_HUMAN
NC score	0.010135 (rank : 9)	θ value	8.99809 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
NC score	0.010111 (rank : 10)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).