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Network neighborhood for query Sequence : DP13B_HUMAN

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DP13B_HUMAN
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DP13A_HUMAN
θ value	0 (rank : 1)	NC score	0.952539 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	107	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	0 (rank : 2)	NC score	0.957921 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13B_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
θ value	0 (rank : 4)	NC score	0.986139 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

CENB2_HUMAN
θ value	4.15078e-21 (rank : 5)	NC score	0.381255 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	425	Shared Neighborhood Hits	31
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	1.2077e-20 (rank : 6)	NC score	0.369168 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	395	Shared Neighborhood Hits	29
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

RHG26_HUMAN
θ value	9.26847e-13 (rank : 7)	NC score	0.333335 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

OPHN1_MOUSE
θ value	4.30538e-10 (rank : 8)	NC score	0.337092 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_HUMAN
θ value	8.11959e-09 (rank : 9)	NC score	0.330630 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

CENB1_HUMAN
θ value	6.87365e-08 (rank : 10)	NC score	0.325650 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	383	Shared Neighborhood Hits	30
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DOCK9_MOUSE
θ value	4.1701e-05 (rank : 11)	NC score	0.064964 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DDEF2_MOUSE
θ value	0.00020696 (rank : 12)	NC score	0.252436 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	625	Shared Neighborhood Hits	22
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
θ value	0.00102713 (rank : 13)	NC score	0.249308 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	599	Shared Neighborhood Hits	22
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKK_HUMAN
θ value	0.00228821 (rank : 14)	NC score	0.108263 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	378	Shared Neighborhood Hits	16
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DDFL1_HUMAN
θ value	0.00298849 (rank : 15)	NC score	0.185463 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	353	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDEF1_MOUSE
θ value	0.0113563 (rank : 16)	NC score	0.234116 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	592	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDFL1_MOUSE
θ value	0.0563607 (rank : 17)	NC score	0.166039 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	324	Shared Neighborhood Hits	16
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

FGD4_MOUSE
θ value	0.0736092 (rank : 18)	NC score	0.058301 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MTDC_HUMAN
θ value	0.125558 (rank : 19)	NC score	0.080402 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_MOUSE
θ value	0.163984 (rank : 20)	NC score	0.072197 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

FGD4_HUMAN
θ value	0.21417 (rank : 21)	NC score	0.048296 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	219	Shared Neighborhood Hits	21
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

DGKD_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.078231 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

JIP1_HUMAN
θ value	0.365318 (rank : 23)	NC score	0.080274 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	271	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

DGKH_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.076327 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	255	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

POF1B_HUMAN
θ value	0.62314 (rank : 25)	NC score	0.021871 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	494	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

MRCKG_MOUSE
θ value	0.813845 (rank : 26)	NC score	0.003580 (rank : 83)
Query Neighborhood Hits	58	Target Neighborhood Hits	1466	Shared Neighborhood Hits	13
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

ZN292_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.021719 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	918	Shared Neighborhood Hits	7
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

CYH2_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.040753 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	1.81305 (rank : 29)	NC score	0.040692 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	171	Shared Neighborhood Hits	12
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

GOGA4_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.014720 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	1939	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ITPR1_MOUSE
θ value	1.81305 (rank : 31)	NC score	0.021336 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

KIF1B_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.011788 (rank : 74)
Query Neighborhood Hits	58	Target Neighborhood Hits	178	Shared Neighborhood Hits	9
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

2ACA_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.020174 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q06190, Q06189, Q9NPQ5	Gene names	PPP2R3A, PPP2R3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B (PP2A, subunit B, B''-PR72/PR130) (PP2A, subunit B, B72/B130 isoforms) (PP2A, subunit B, PR72/PR130 isoforms) (PP2A, subunit B, R3 isoform).

NOTC3_HUMAN
θ value	2.36792 (rank : 34)	NC score	0.016283 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	1062	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

BPAEA_HUMAN
θ value	3.0926 (rank : 35)	NC score	0.011588 (rank : 75)
Query Neighborhood Hits	58	Target Neighborhood Hits	1369	Shared Neighborhood Hits	22
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

FGD1_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.040615 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	367	Shared Neighborhood Hits	17
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

KIF1B_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.010958 (rank : 78)
Query Neighborhood Hits	58	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

TPM1_HUMAN
θ value	3.0926 (rank : 38)	NC score	0.013169 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	716	Shared Neighborhood Hits	13
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	3.0926 (rank : 39)	NC score	0.013118 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

FGD1_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.036440 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	387	Shared Neighborhood Hits	14
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

JIP1_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.071766 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	259	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.061328 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.058811 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

KMHN1_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.011028 (rank : 77)
Query Neighborhood Hits	58	Target Neighborhood Hits	950	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

MAP1A_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.011301 (rank : 76)
Query Neighborhood Hits	58	Target Neighborhood Hits	1626	Shared Neighborhood Hits	19
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NOTC3_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.015103 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	975	Shared Neighborhood Hits	16
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ANR26_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.016079 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	1554	Shared Neighborhood Hits	29
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CEP35_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.012936 (rank : 71)
Query Neighborhood Hits	58	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CYH3_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.037251 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

LAMA2_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.005043 (rank : 82)
Query Neighborhood Hits	58	Target Neighborhood Hits	1092	Shared Neighborhood Hits	12
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

PRG4_MOUSE
θ value	6.88961 (rank : 51)	NC score	0.009189 (rank : 79)
Query Neighborhood Hits	58	Target Neighborhood Hits	624	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VDP_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.011898 (rank : 73)
Query Neighborhood Hits	58	Target Neighborhood Hits	469	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

ANGP1_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.006896 (rank : 81)
Query Neighborhood Hits	58	Target Neighborhood Hits	254	Shared Neighborhood Hits	11
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

ANGP2_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.012242 (rank : 72)
Query Neighborhood Hits	58	Target Neighborhood Hits	400	Shared Neighborhood Hits	12
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

BFSP2_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.003249 (rank : 84)
Query Neighborhood Hits	58	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NVD9, Q63832, Q6P5N4, Q8VDD6	Gene names	Bfsp2
Domain Architecture	No domain graphic available
Description	Phakinin (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 49) (CP49) (49 kDa cytoskeletal protein).

CAR11_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.007291 (rank : 80)
Query Neighborhood Hits	58	Target Neighborhood Hits	690	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CYH1_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.037176 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

MRCKA_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.002849 (rank : 85)
Query Neighborhood Hits	58	Target Neighborhood Hits	1999	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

ARFG1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.093307 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.095537 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.089592 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.088011 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CENA1_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.099627 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.093016 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.094428 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CEND1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.091077 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.092301 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	260	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.095560 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CEND3_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.085962 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.084494 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CENG1_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.077750 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	544	Shared Neighborhood Hits	15
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG1_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.078584 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	531	Shared Neighborhood Hits	15
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.072616 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	471	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG2_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.072691 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	463	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG3_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.076328 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.076647 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	467	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

GIT1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.061175 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.061008 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

GIT2_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.062689 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	381	Shared Neighborhood Hits	14
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.062615 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

NUPL_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.050485 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	8
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

SMAP1_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.094426 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.096694 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	120	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.094676 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.094182 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

Hits sorted by NC score

DP13B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q8NEU8, Q8N4R7, Q9NVL2	Gene names	DIP13B, APPL2
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13B_MOUSE
NC score	0.986139 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3G9, Q99LT7	Gene names	Dip13b, Appl2, Dip3b
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 beta (Dip13 beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2).

DP13A_MOUSE
NC score	0.957921 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_HUMAN
NC score	0.952539 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	107	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

CENB2_HUMAN
NC score	0.381255 (rank : 5)	θ value	4.15078e-21 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	425	Shared Neighborhood Hits	31
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
NC score	0.369168 (rank : 6)	θ value	1.2077e-20 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	395	Shared Neighborhood Hits	29
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

OPHN1_MOUSE
NC score	0.337092 (rank : 7)	θ value	4.30538e-10 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG26_HUMAN
NC score	0.333335 (rank : 8)	θ value	9.26847e-13 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

OPHN1_HUMAN
NC score	0.330630 (rank : 9)	θ value	8.11959e-09 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	161	Shared Neighborhood Hits	14
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

CENB1_HUMAN
NC score	0.325650 (rank : 10)	θ value	6.87365e-08 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	383	Shared Neighborhood Hits	30
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DDEF2_MOUSE
NC score	0.252436 (rank : 11)	θ value	0.00020696 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	625	Shared Neighborhood Hits	22
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_HUMAN
NC score	0.249308 (rank : 12)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	599	Shared Neighborhood Hits	22
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF1_MOUSE
NC score	0.234116 (rank : 13)	θ value	0.0113563 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	592	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDFL1_HUMAN
NC score	0.185463 (rank : 14)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	353	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
NC score	0.166039 (rank : 15)	θ value	0.0563607 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	324	Shared Neighborhood Hits	16
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DGKK_HUMAN
NC score	0.108263 (rank : 16)	θ value	0.00228821 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	378	Shared Neighborhood Hits	16
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CENA1_HUMAN
NC score	0.099627 (rank : 17)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	87	Shared Neighborhood Hits	19
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SMAP1_MOUSE
NC score	0.096694 (rank : 18)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	58	Target Neighborhood Hits	120	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CEND2_HUMAN
NC score	0.095560 (rank : 19)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	166	Shared Neighborhood Hits	18
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

ARFG1_MOUSE
NC score	0.095537 (rank : 20)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

SMP1L_HUMAN
NC score	0.094676 (rank : 21)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	58	Target Neighborhood Hits	74	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

CENA2_MOUSE
NC score	0.094428 (rank : 22)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

SMAP1_HUMAN
NC score	0.094426 (rank : 23)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	58	Target Neighborhood Hits	98	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_MOUSE
NC score	0.094182 (rank : 24)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

ARFG1_HUMAN
NC score	0.093307 (rank : 25)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	60	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

CENA2_HUMAN
NC score	0.093016 (rank : 26)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	83	Shared Neighborhood Hits	15
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CEND1_MOUSE
NC score	0.092301 (rank : 27)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	260	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.091077 (rank : 28)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	284	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

ARFG3_HUMAN
NC score	0.089592 (rank : 29)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	56	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
NC score	0.088011 (rank : 30)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

CEND3_HUMAN
NC score	0.085962 (rank : 31)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	275	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CEND3_MOUSE
NC score	0.084494 (rank : 32)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	228	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

MTDC_HUMAN
NC score	0.080402 (rank : 33)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

JIP1_HUMAN
NC score	0.080274 (rank : 34)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	271	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

CENG1_MOUSE
NC score	0.078584 (rank : 35)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	58	Target Neighborhood Hits	531	Shared Neighborhood Hits	15
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

DGKD_HUMAN
NC score	0.078231 (rank : 36)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	231	Shared Neighborhood Hits	15
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CENG1_HUMAN
NC score	0.077750 (rank : 37)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	58	Target Neighborhood Hits	544	Shared Neighborhood Hits	15
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CENG3_MOUSE
NC score	0.076647 (rank : 38)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	58	Target Neighborhood Hits	467	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.076328 (rank : 39)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	58	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

DGKH_HUMAN
NC score	0.076327 (rank : 40)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	255	Shared Neighborhood Hits	20
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CENG2_MOUSE
NC score	0.072691 (rank : 41)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	58	Target Neighborhood Hits	463	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG2_HUMAN
NC score	0.072616 (rank : 42)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	58	Target Neighborhood Hits	471	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

MTDC_MOUSE
NC score	0.072197 (rank : 43)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

JIP1_MOUSE
NC score	0.071766 (rank : 44)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	259	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

DOCK9_MOUSE
NC score	0.064964 (rank : 45)	θ value	4.1701e-05 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

GIT2_HUMAN
NC score	0.062689 (rank : 46)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	58	Target Neighborhood Hits	381	Shared Neighborhood Hits	14
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

GIT2_MOUSE
NC score	0.062615 (rank : 47)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	58	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

JIP2_HUMAN
NC score	0.061328 (rank : 48)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	288	Shared Neighborhood Hits	12
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

GIT1_HUMAN
NC score	0.061175 (rank : 49)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	58	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
NC score	0.061008 (rank : 50)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	58	Target Neighborhood Hits	341	Shared Neighborhood Hits	12
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

JIP2_MOUSE
NC score	0.058811 (rank : 51)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	144	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

FGD4_MOUSE
NC score	0.058301 (rank : 52)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

NUPL_HUMAN
NC score	0.050485 (rank : 53)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	8
SwissProt Accessions	P52594, Q15277, Q4VAS0, Q4VAS1, Q4VAS3, Q53QT8, Q53R11	Gene names	HRB, RAB, RIP
Domain Architecture
Description	Nucleoporin-like protein RIP (HIV-1 Rev-binding protein) (Rev- interacting protein) (Rev/Rex activation domain-binding protein).

FGD4_HUMAN
NC score	0.048296 (rank : 54)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	219	Shared Neighborhood Hits	21
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CYH2_HUMAN
NC score	0.040753 (rank : 55)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.040692 (rank : 56)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	171	Shared Neighborhood Hits	12
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

FGD1_HUMAN
NC score	0.040615 (rank : 57)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	367	Shared Neighborhood Hits	17
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CYH3_MOUSE
NC score	0.037251 (rank : 58)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	148	Shared Neighborhood Hits	13
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CYH1_HUMAN
NC score	0.037176 (rank : 59)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	184	Shared Neighborhood Hits	13
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

FGD1_MOUSE
NC score	0.036440 (rank : 60)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	387	Shared Neighborhood Hits	14
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

POF1B_HUMAN
NC score	0.021871 (rank : 61)	θ value	0.62314 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	494	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

ZN292_HUMAN
NC score	0.021719 (rank : 62)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	918	Shared Neighborhood Hits	7
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

ITPR1_MOUSE
NC score	0.021336 (rank : 63)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

2ACA_HUMAN
NC score	0.020174 (rank : 64)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	2
SwissProt Accessions	Q06190, Q06189, Q9NPQ5	Gene names	PPP2R3A, PPP2R3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B (PP2A, subunit B, B''-PR72/PR130) (PP2A, subunit B, B72/B130 isoforms) (PP2A, subunit B, PR72/PR130 isoforms) (PP2A, subunit B, R3 isoform).

NOTC3_HUMAN
NC score	0.016283 (rank : 65)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	1062	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ANR26_MOUSE
NC score	0.016079 (rank : 66)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	1554	Shared Neighborhood Hits	29
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

NOTC3_MOUSE
NC score	0.015103 (rank : 67)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	975	Shared Neighborhood Hits	16
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

GOGA4_MOUSE
NC score	0.014720 (rank : 68)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	1939	Shared Neighborhood Hits	25
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

TPM1_HUMAN
NC score	0.013169 (rank : 69)	θ value	3.0926 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	716	Shared Neighborhood Hits	13
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
NC score	0.013118 (rank : 70)	θ value	3.0926 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

CEP35_HUMAN
NC score	0.012936 (rank : 71)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

ANGP2_HUMAN
NC score	0.012242 (rank : 72)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	400	Shared Neighborhood Hits	12
SwissProt Accessions	O15123, Q9NRR7, Q9P2Y7	Gene names	ANGPT2
Domain Architecture
Description	Angiopoietin-2 precursor (ANG-2).

VDP_MOUSE
NC score	0.011898 (rank : 73)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	469	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

KIF1B_HUMAN
NC score	0.011788 (rank : 74)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	178	Shared Neighborhood Hits	9
SwissProt Accessions	O60333, Q96Q94, Q9BV80, Q9P280	Gene names	KIF1B, KIAA0591, KIAA1448
Domain Architecture
Description	Kinesin-like protein KIF1B (Klp).

BPAEA_HUMAN
NC score	0.011588 (rank : 75)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	1369	Shared Neighborhood Hits	22
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MAP1A_HUMAN
NC score	0.011301 (rank : 76)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	1626	Shared Neighborhood Hits	19
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

KMHN1_HUMAN
NC score	0.011028 (rank : 77)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	950	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KIF1B_MOUSE
NC score	0.010958 (rank : 78)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	167	Shared Neighborhood Hits	8
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

PRG4_MOUSE
NC score	0.009189 (rank : 79)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	624	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CAR11_HUMAN
NC score	0.007291 (rank : 80)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	690	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

ANGP1_HUMAN
NC score	0.006896 (rank : 81)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	254	Shared Neighborhood Hits	11
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

LAMA2_HUMAN
NC score	0.005043 (rank : 82)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	1092	Shared Neighborhood Hits	12
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MRCKG_MOUSE
NC score	0.003580 (rank : 83)	θ value	0.813845 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	1466	Shared Neighborhood Hits	13
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

BFSP2_MOUSE
NC score	0.003249 (rank : 84)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q6NVD9, Q63832, Q6P5N4, Q8VDD6	Gene names	Bfsp2
Domain Architecture	No domain graphic available
Description	Phakinin (Beaded filament structural protein 2) (Lens fiber cell beaded filament protein CP 49) (CP49) (49 kDa cytoskeletal protein).

MRCKA_HUMAN
NC score	0.002849 (rank : 85)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	1999	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).