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Network neighborhood for query Sequence : C1TC_MOUSE

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C1TC_MOUSE
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

C1TC_HUMAN
θ value	0 (rank : 1)	NC score	0.998363 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

MTDC_MOUSE
θ value	1.04822e-48 (rank : 3)	NC score	0.839083 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
θ value	3.37202e-47 (rank : 4)	NC score	0.836462 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

SPTN5_HUMAN
θ value	1.38821 (rank : 5)	NC score	0.016736 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	674	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

DPYL4_HUMAN
θ value	2.36792 (rank : 6)	NC score	0.025790 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	O14531, O00240, Q5T0Q7	Gene names	DPYSL4, CRMP3, ULIP4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

AT8A1_MOUSE
θ value	3.0926 (rank : 7)	NC score	0.008705 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P70704	Gene names	Atp8a1, Atpc1
Domain Architecture
Description	Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (Chromaffin granule ATPase II) (ATPase class I type 8A member 1).

DPYL2_HUMAN
θ value	3.0926 (rank : 8)	NC score	0.024799 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q16555, O00424	Gene names	DPYSL2, CRMP2
Domain Architecture
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3).

ITAL_MOUSE
θ value	3.0926 (rank : 9)	NC score	0.012602 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P24063	Gene names	Itgal, Lfa-1, Ly-15
Domain Architecture
Description	Integrin alpha-L precursor (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen Ly-15) (CD11a antigen).

PTPRJ_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.013277 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

TRI10_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.010924 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

DPYL4_MOUSE
θ value	4.03905 (rank : 12)	NC score	0.024392 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	O35098, O08886	Gene names	Dpysl4, Crmp3, Ulip4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL2_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.023408 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	O08553, Q6P5D0	Gene names	Dpysl2, Crmp2, Ulip2
Domain Architecture	No domain graphic available
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (ULIP 2 protein).

NNTM_MOUSE
θ value	5.27518 (rank : 14)	NC score	0.026423 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

WWC3_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.017681 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

DTX2_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.009271 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3P2, Q9CZV3, Q9ER07, Q9ER08	Gene names	Dtx2
Domain Architecture
Description	Protein deltex-2 (Deltex-2) (Deltex2) (mDTX2).

Hits sorted by NC score

C1TC_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	Q922D8	Gene names	Mthfd1
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

C1TC_HUMAN
NC score	0.998363 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P11586, Q86VC9, Q9BVP5	Gene names	MTHFD1, MTHFC, MTHFD
Domain Architecture
Description	C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)].

MTDC_MOUSE
NC score	0.839083 (rank : 3)	θ value	1.04822e-48 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	P18155, Q3TMN4	Gene names	Mthfd2, Nmdmc
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

MTDC_HUMAN
NC score	0.836462 (rank : 4)	θ value	3.37202e-47 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	P13995, Q53G90, Q53GV5, Q53S36	Gene names	MTHFD2, NMDMC
Domain Architecture
Description	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)].

NNTM_MOUSE
NC score	0.026423 (rank : 5)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q61941, Q9JK70	Gene names	Nnt
Domain Architecture
Description	NAD(P) transhydrogenase, mitochondrial precursor (EC 1.6.1.2) (Pyridine nucleotide transhydrogenase) (Nicotinamide nucleotide transhydrogenase).

DPYL4_HUMAN
NC score	0.025790 (rank : 6)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	O14531, O00240, Q5T0Q7	Gene names	DPYSL4, CRMP3, ULIP4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL2_HUMAN
NC score	0.024799 (rank : 7)	θ value	3.0926 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	Q16555, O00424	Gene names	DPYSL2, CRMP2
Domain Architecture
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (N2A3).

DPYL4_MOUSE
NC score	0.024392 (rank : 8)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	O35098, O08886	Gene names	Dpysl4, Crmp3, Ulip4
Domain Architecture
Description	Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP4 protein).

DPYL2_MOUSE
NC score	0.023408 (rank : 9)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	O08553, Q6P5D0	Gene names	Dpysl2, Crmp2, Ulip2
Domain Architecture	No domain graphic available
Description	Dihydropyrimidinase-related protein 2 (DRP-2) (ULIP 2 protein).

WWC3_HUMAN
NC score	0.017681 (rank : 10)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	193	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

SPTN5_HUMAN
NC score	0.016736 (rank : 11)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	674	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

PTPRJ_MOUSE
NC score	0.013277 (rank : 12)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

ITAL_MOUSE
NC score	0.012602 (rank : 13)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	P24063	Gene names	Itgal, Lfa-1, Ly-15
Domain Architecture
Description	Integrin alpha-L precursor (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen Ly-15) (CD11a antigen).

TRI10_HUMAN
NC score	0.010924 (rank : 14)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

DTX2_MOUSE
NC score	0.009271 (rank : 15)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3P2, Q9CZV3, Q9ER07, Q9ER08	Gene names	Dtx2
Domain Architecture
Description	Protein deltex-2 (Deltex-2) (Deltex2) (mDTX2).

AT8A1_MOUSE
NC score	0.008705 (rank : 16)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P70704	Gene names	Atp8a1, Atpc1
Domain Architecture
Description	Probable phospholipid-transporting ATPase IA (EC 3.6.3.1) (Chromaffin granule ATPase II) (ATPase class I type 8A member 1).