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Network neighborhood for query Sequence : APC10_HUMAN

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APC10_HUMAN
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

APC10_HUMAN
θ value	4.94618e-107 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
θ value	2.45477e-106 (rank : 2)	NC score	0.999523 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

HECD3_HUMAN
θ value	3.41135e-07 (rank : 3)	NC score	0.340571 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	3.41135e-07 (rank : 4)	NC score	0.338706 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

CUL7_HUMAN
θ value	9.29e-05 (rank : 5)	NC score	0.361885 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

PARC_MOUSE
θ value	0.000270298 (rank : 6)	NC score	0.289799 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

HERC2_HUMAN
θ value	0.000602161 (rank : 7)	NC score	0.204778 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

PARC_HUMAN
θ value	0.00228821 (rank : 8)	NC score	0.274878 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

HERC2_MOUSE
θ value	0.00509761 (rank : 9)	NC score	0.196244 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

FOG1_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.007202 (rank : 23)
Query Neighborhood Hits	10	Target Neighborhood Hits	1237	Shared Neighborhood Hits	2
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

EDD1_HUMAN
θ value	θ > 10 (rank : 11)	NC score	0.058179 (rank : 14)
Query Neighborhood Hits	10	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 12)	NC score	0.058252 (rank : 13)
Query Neighborhood Hits	10	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD2_HUMAN
θ value	θ > 10 (rank : 13)	NC score	0.055064 (rank : 18)
Query Neighborhood Hits	10	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 14)	NC score	0.055741 (rank : 15)
Query Neighborhood Hits	10	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HERC3_HUMAN
θ value	θ > 10 (rank : 15)	NC score	0.052970 (rank : 21)
Query Neighborhood Hits	10	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 16)	NC score	0.054919 (rank : 20)
Query Neighborhood Hits	10	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 17)	NC score	0.055002 (rank : 19)
Query Neighborhood Hits	10	Target Neighborhood Hits	443	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 18)	NC score	0.055103 (rank : 17)
Query Neighborhood Hits	10	Target Neighborhood Hits	406	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TRIPC_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.059644 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	319	Shared Neighborhood Hits	4
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 20)	NC score	0.055398 (rank : 16)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 21)	NC score	0.050820 (rank : 22)
Query Neighborhood Hits	10	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.058953 (rank : 11)
Query Neighborhood Hits	10	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.058609 (rank : 12)
Query Neighborhood Hits	10	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

Hits sorted by NC score

APC10_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.94618e-107 (rank : 1)
Query Neighborhood Hits	10	Target Neighborhood Hits	10	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
NC score	0.999523 (rank : 2)	θ value	2.45477e-106 (rank : 2)
Query Neighborhood Hits	10	Target Neighborhood Hits	9	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

CUL7_HUMAN
NC score	0.361885 (rank : 3)	θ value	9.29e-05 (rank : 5)
Query Neighborhood Hits	10	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

HECD3_HUMAN
NC score	0.340571 (rank : 4)	θ value	3.41135e-07 (rank : 3)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
NC score	0.338706 (rank : 5)	θ value	3.41135e-07 (rank : 4)
Query Neighborhood Hits	10	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

PARC_MOUSE
NC score	0.289799 (rank : 6)	θ value	0.000270298 (rank : 6)
Query Neighborhood Hits	10	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PARC_HUMAN
NC score	0.274878 (rank : 7)	θ value	0.00228821 (rank : 8)
Query Neighborhood Hits	10	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

HERC2_HUMAN
NC score	0.204778 (rank : 8)	θ value	0.000602161 (rank : 7)
Query Neighborhood Hits	10	Target Neighborhood Hits	163	Shared Neighborhood Hits	9
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.196244 (rank : 9)	θ value	0.00509761 (rank : 9)
Query Neighborhood Hits	10	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

TRIPC_HUMAN
NC score	0.059644 (rank : 10)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	10	Target Neighborhood Hits	319	Shared Neighborhood Hits	4
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3C_HUMAN
NC score	0.058953 (rank : 11)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	10	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.058609 (rank : 12)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	10	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

EDD1_MOUSE
NC score	0.058252 (rank : 13)	θ value	θ > 10 (rank : 12)
Query Neighborhood Hits	10	Target Neighborhood Hits	167	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.058179 (rank : 14)	θ value	θ > 10 (rank : 11)
Query Neighborhood Hits	10	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HECD2_MOUSE
NC score	0.055741 (rank : 15)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	10	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.055398 (rank : 16)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	10	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HUWE1_MOUSE
NC score	0.055103 (rank : 17)	θ value	θ > 10 (rank : 18)
Query Neighborhood Hits	10	Target Neighborhood Hits	406	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HECD2_HUMAN
NC score	0.055064 (rank : 18)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	10	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HUWE1_HUMAN
NC score	0.055002 (rank : 19)	θ value	θ > 10 (rank : 17)
Query Neighborhood Hits	10	Target Neighborhood Hits	443	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HERC5_HUMAN
NC score	0.054919 (rank : 20)	θ value	θ > 10 (rank : 16)
Query Neighborhood Hits	10	Target Neighborhood Hits	66	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.052970 (rank : 21)	θ value	θ > 10 (rank : 15)
Query Neighborhood Hits	10	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

UBE3A_MOUSE
NC score	0.050820 (rank : 22)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	10	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

FOG1_MOUSE
NC score	0.007202 (rank : 23)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	10	Target Neighborhood Hits	1237	Shared Neighborhood Hits	2
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).