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Network neighborhood for query Sequence : UBE3C_HUMAN

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UBE3C_HUMAN
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

UBE3C_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	0 (rank : 2)	NC score	0.999428 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	48	Shared Neighborhood Hits	44
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_HUMAN
θ value	2.49495e-50 (rank : 3)	NC score	0.915554 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

HUWE1_HUMAN
θ value	1.51363e-47 (rank : 4)	NC score	0.862853 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	443	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	1.51363e-47 (rank : 5)	NC score	0.863909 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	406	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NED4L_HUMAN
θ value	1.97686e-47 (rank : 6)	NC score	0.804118 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	1.97686e-47 (rank : 7)	NC score	0.805103 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

UBE3A_MOUSE
θ value	9.81109e-47 (rank : 8)	NC score	0.911028 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

NEDD4_HUMAN
θ value	1.67352e-46 (rank : 9)	NC score	0.819748 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NEDD4_MOUSE
θ value	1.08474e-45 (rank : 10)	NC score	0.824836 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

WWP2_HUMAN
θ value	1.19932e-44 (rank : 11)	NC score	0.859351 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

SMUF1_HUMAN
θ value	4.55743e-44 (rank : 12)	NC score	0.874612 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	1.01529e-43 (rank : 13)	NC score	0.871004 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

WWP2_MOUSE
θ value	1.32601e-43 (rank : 14)	NC score	0.860329 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

ITCH_MOUSE
θ value	4.2656e-42 (rank : 15)	NC score	0.864363 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
θ value	4.2656e-42 (rank : 16)	NC score	0.849878 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	262	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	4.2656e-42 (rank : 17)	NC score	0.856585 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	138	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

SMUF2_HUMAN
θ value	5.57106e-42 (rank : 18)	NC score	0.868746 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ITCH_HUMAN
θ value	2.76489e-41 (rank : 19)	NC score	0.856544 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	162	Shared Neighborhood Hits	33
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

HERC3_HUMAN
θ value	2.67802e-36 (rank : 20)	NC score	0.749779 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD2_MOUSE
θ value	4.568e-36 (rank : 21)	NC score	0.900162 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
θ value	5.0505e-35 (rank : 22)	NC score	0.886806 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HECD2_HUMAN
θ value	6.59618e-35 (rank : 23)	NC score	0.897182 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_MOUSE
θ value	4.27553e-34 (rank : 24)	NC score	0.885621 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HERC5_HUMAN
θ value	1.73987e-27 (rank : 25)	NC score	0.749404 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

TRIPC_HUMAN
θ value	3.87602e-27 (rank : 26)	NC score	0.818236 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HECD1_HUMAN
θ value	5.79196e-23 (rank : 27)	NC score	0.588085 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	371	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HERC2_HUMAN
θ value	1.02238e-19 (rank : 28)	NC score	0.626731 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	34
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD3_HUMAN
θ value	1.33526e-19 (rank : 29)	NC score	0.747382 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	1.74391e-19 (rank : 30)	NC score	0.750337 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_MOUSE
θ value	2.27762e-19 (rank : 31)	NC score	0.629561 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	167	Shared Neighborhood Hits	33
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

EDD1_HUMAN
θ value	9.56915e-18 (rank : 32)	NC score	0.702097 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	9.56915e-18 (rank : 33)	NC score	0.703674 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	167	Shared Neighborhood Hits	33
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

K1333_MOUSE
θ value	0.0113563 (rank : 34)	NC score	0.110691 (rank : 56)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

COG3_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.044467 (rank : 105)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

DC1I1_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.021333 (rank : 110)
Query Neighborhood Hits	51	Target Neighborhood Hits	183	Shared Neighborhood Hits	3
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

DC1I1_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.021348 (rank : 109)
Query Neighborhood Hits	51	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

IQCB1_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.034825 (rank : 106)
Query Neighborhood Hits	51	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q15051, Q5DKQ7, Q8NI79, Q9BS08	Gene names	IQCB1, KIAA0036, NPHP5
Domain Architecture
Description	IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5).

K1333_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.068962 (rank : 81)
Query Neighborhood Hits	51	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

MYO3A_HUMAN
θ value	2.36792 (rank : 40)	NC score	-0.000998 (rank : 118)
Query Neighborhood Hits	51	Target Neighborhood Hits	1033	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

DDX27_MOUSE
θ value	3.0926 (rank : 41)	NC score	0.005074 (rank : 115)
Query Neighborhood Hits	51	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

TRPC2_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.005751 (rank : 114)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

ASPM_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.011652 (rank : 112)
Query Neighborhood Hits	51	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

COG3_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.028936 (rank : 107)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

MYO3A_MOUSE
θ value	5.27518 (rank : 45)	NC score	-0.001699 (rank : 119)
Query Neighborhood Hits	51	Target Neighborhood Hits	902	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

IQCB1_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.023836 (rank : 108)
Query Neighborhood Hits	51	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP00, Q3TNK4, Q8K306	Gene names	Iqcb1, Kiaa0036
Domain Architecture	No domain graphic available
Description	IQ calmodulin-binding motif-containing protein 1.

KPCD3_MOUSE
θ value	6.88961 (rank : 47)	NC score	-0.003682 (rank : 120)
Query Neighborhood Hits	51	Target Neighborhood Hits	901	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

LBH2_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.013801 (rank : 111)
Query Neighborhood Hits	51	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P08910	Gene names	ABHD2, LABH2
Domain Architecture
Description	Abhydrolase domain-containing protein 2 (Protein PHPS1-2).

TITF1_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.000593 (rank : 116)
Query Neighborhood Hits	51	Target Neighborhood Hits	332	Shared Neighborhood Hits	3
SwissProt Accessions	P43699, O14954, O14955, Q9BRJ8	Gene names	TITF1, NKX2-1, NKX2A, TTF1
Domain Architecture
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1) (Homeobox protein NK-2 homolog A).

TITF1_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.000567 (rank : 117)
Query Neighborhood Hits	51	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	P50220	Gene names	Titf1, Nkx-2.1, Nkx2-1, Ttf1
Domain Architecture	No domain graphic available
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1).

ZWINT_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.006357 (rank : 113)
Query Neighborhood Hits	51	Target Neighborhood Hits	497	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

ALS2_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.061455 (rank : 85)
Query Neighborhood Hits	51	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.059303 (rank : 89)
Query Neighborhood Hits	51	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

APBB2_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.086804 (rank : 69)
Query Neighborhood Hits	51	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.083728 (rank : 70)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

APBB3_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.058967 (rank : 90)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APBB3_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.059309 (rank : 88)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

APC10_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.058953 (rank : 91)
Query Neighborhood Hits	51	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

APC10_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.056551 (rank : 93)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

BAG3_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.192058 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAG3_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.162066 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	513	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CUL7_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.071136 (rank : 77)
Query Neighborhood Hits	51	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

DOC2A_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.052131 (rank : 101)
Query Neighborhood Hits	51	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.054892 (rank : 95)
Query Neighborhood Hits	51	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.050586 (rank : 104)
Query Neighborhood Hits	51	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

FA62A_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.062135 (rank : 84)
Query Neighborhood Hits	51	Target Neighborhood Hits	168	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.073706 (rank : 75)
Query Neighborhood Hits	51	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

GAS7_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.129911 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	258	Shared Neighborhood Hits	13
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.129270 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	259	Shared Neighborhood Hits	13
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

MAGI1_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.136450 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	388	Shared Neighborhood Hits	13
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.137054 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	403	Shared Neighborhood Hits	14
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.137198 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	373	Shared Neighborhood Hits	13
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI2_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.147179 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	370	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MYCB2_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.050588 (rank : 103)
Query Neighborhood Hits	51	Target Neighborhood Hits	390	Shared Neighborhood Hits	7
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

PARC_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.053263 (rank : 99)
Query Neighborhood Hits	51	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

PARC_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.054139 (rank : 97)
Query Neighborhood Hits	51	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

PIN1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.208526 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.207190 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PINL_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.247871 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

PKHA5_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.147086 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PRP40_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.110000 (rank : 57)
Query Neighborhood Hits	51	Target Neighborhood Hits	442	Shared Neighborhood Hits	13
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.108946 (rank : 58)
Query Neighborhood Hits	51	Target Neighborhood Hits	447	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RASL1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.061284 (rank : 86)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.057886 (rank : 92)
Query Neighborhood Hits	51	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.054421 (rank : 96)
Query Neighborhood Hits	51	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RCBT1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.070361 (rank : 79)
Query Neighborhood Hits	51	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

RCBT1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.072265 (rank : 76)
Query Neighborhood Hits	51	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.078022 (rank : 74)
Query Neighborhood Hits	51	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.079049 (rank : 71)
Query Neighborhood Hits	51	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC1_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.093434 (rank : 64)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.091494 (rank : 65)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

RCC2_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.097243 (rank : 61)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.096546 (rank : 62)
Query Neighborhood Hits	51	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RHG12_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.052904 (rank : 100)
Query Neighborhood Hits	51	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.061002 (rank : 87)
Query Neighborhood Hits	51	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RPGR_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.095276 (rank : 63)
Query Neighborhood Hits	51	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RPGR_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.090297 (rank : 67)
Query Neighborhood Hits	51	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

SAV1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.265691 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.266006 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SETD2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.063290 (rank : 83)
Query Neighborhood Hits	51	Target Neighborhood Hits	412	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SRGEF_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.101492 (rank : 59)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.098260 (rank : 60)
Query Neighborhood Hits	51	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

STXB4_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.078928 (rank : 72)
Query Neighborhood Hits	51	Target Neighborhood Hits	616	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.078890 (rank : 73)
Query Neighborhood Hits	51	Target Neighborhood Hits	629	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

TOLIP_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.051868 (rank : 102)
Query Neighborhood Hits	51	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

TOLIP_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.053782 (rank : 98)
Query Neighborhood Hits	51	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

UN13A_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.067269 (rank : 82)
Query Neighborhood Hits	51	Target Neighborhood Hits	285	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.070346 (rank : 80)
Query Neighborhood Hits	51	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.070380 (rank : 78)
Query Neighborhood Hits	51	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

WBP4_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.056410 (rank : 94)
Query Neighborhood Hits	51	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WBS16_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.089384 (rank : 68)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.091365 (rank : 66)
Query Neighborhood Hits	51	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

WWC1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.222113 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.222867 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWOX_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.206706 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.204928 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWTR1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.177957 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.180604 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.169990 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.293542 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

UBE3C_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.999428 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	48	Shared Neighborhood Hits	44
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_HUMAN
NC score	0.915554 (rank : 3)	θ value	2.49495e-50 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.911028 (rank : 4)	θ value	9.81109e-47 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HECD2_MOUSE
NC score	0.900162 (rank : 5)	θ value	4.568e-36 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	38	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.897182 (rank : 6)	θ value	6.59618e-35 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

K0317_HUMAN
NC score	0.886806 (rank : 7)	θ value	5.0505e-35 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	46	Shared Neighborhood Hits	35
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.885621 (rank : 8)	θ value	4.27553e-34 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

SMUF1_HUMAN
NC score	0.874612 (rank : 9)	θ value	4.55743e-44 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	135	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.871004 (rank : 10)	θ value	1.01529e-43 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
NC score	0.868746 (rank : 11)	θ value	5.57106e-42 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

ITCH_MOUSE
NC score	0.864363 (rank : 12)	θ value	4.2656e-42 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

HUWE1_MOUSE
NC score	0.863909 (rank : 13)	θ value	1.51363e-47 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	406	Shared Neighborhood Hits	33
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.862853 (rank : 14)	θ value	1.51363e-47 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	443	Shared Neighborhood Hits	33
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

WWP2_MOUSE
NC score	0.860329 (rank : 15)	θ value	1.32601e-43 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	118	Shared Neighborhood Hits	33
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.859351 (rank : 16)	θ value	1.19932e-44 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP1_MOUSE
NC score	0.856585 (rank : 17)	θ value	4.2656e-42 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	138	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_HUMAN
NC score	0.856544 (rank : 18)	θ value	2.76489e-41 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	162	Shared Neighborhood Hits	33
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_HUMAN
NC score	0.849878 (rank : 19)	θ value	4.2656e-42 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	262	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

NEDD4_MOUSE
NC score	0.824836 (rank : 20)	θ value	1.08474e-45 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	212	Shared Neighborhood Hits	34
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NEDD4_HUMAN
NC score	0.819748 (rank : 21)	θ value	1.67352e-46 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	214	Shared Neighborhood Hits	35
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.818236 (rank : 22)	θ value	3.87602e-27 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

NED4L_MOUSE
NC score	0.805103 (rank : 23)	θ value	1.97686e-47 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	231	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.804118 (rank : 24)	θ value	1.97686e-47 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	238	Shared Neighborhood Hits	33
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

HECD3_MOUSE
NC score	0.750337 (rank : 25)	θ value	1.74391e-19 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC3_HUMAN
NC score	0.749779 (rank : 26)	θ value	2.67802e-36 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
NC score	0.749404 (rank : 27)	θ value	1.73987e-27 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	66	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HECD3_HUMAN
NC score	0.747382 (rank : 28)	θ value	1.33526e-19 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	49	Shared Neighborhood Hits	33
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.703674 (rank : 29)	θ value	9.56915e-18 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	167	Shared Neighborhood Hits	33
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.702097 (rank : 30)	θ value	9.56915e-18 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HERC2_MOUSE
NC score	0.629561 (rank : 31)	θ value	2.27762e-19 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	167	Shared Neighborhood Hits	33
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.626731 (rank : 32)	θ value	1.02238e-19 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	34
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.588085 (rank : 33)	θ value	5.79196e-23 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	371	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

YAP1_MOUSE
NC score	0.293542 (rank : 34)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	51	Target Neighborhood Hits	96	Shared Neighborhood Hits	13
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_MOUSE
NC score	0.266006 (rank : 35)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	51	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

SAV1_HUMAN
NC score	0.265691 (rank : 36)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

PINL_HUMAN
NC score	0.247871 (rank : 37)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWC1_MOUSE
NC score	0.222867 (rank : 38)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWC1_HUMAN
NC score	0.222113 (rank : 39)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	51	Target Neighborhood Hits	290	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

PIN1_HUMAN
NC score	0.208526 (rank : 40)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
NC score	0.207190 (rank : 41)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	51	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

WWOX_HUMAN
NC score	0.206706 (rank : 42)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	51	Target Neighborhood Hits	115	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.204928 (rank : 43)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	51	Target Neighborhood Hits	118	Shared Neighborhood Hits	13
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

BAG3_HUMAN
NC score	0.192058 (rank : 44)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	51	Target Neighborhood Hits	314	Shared Neighborhood Hits	13
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

WWTR1_MOUSE
NC score	0.180604 (rank : 45)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	13
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.177957 (rank : 46)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.169990 (rank : 47)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	51	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

BAG3_MOUSE
NC score	0.162066 (rank : 48)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	51	Target Neighborhood Hits	513	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MAGI2_MOUSE
NC score	0.147179 (rank : 49)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	51	Target Neighborhood Hits	370	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

PKHA5_HUMAN
NC score	0.147086 (rank : 50)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	51	Target Neighborhood Hits	455	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

MAGI2_HUMAN
NC score	0.137198 (rank : 51)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	51	Target Neighborhood Hits	373	Shared Neighborhood Hits	13
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_MOUSE
NC score	0.137054 (rank : 52)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	51	Target Neighborhood Hits	403	Shared Neighborhood Hits	14
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.136450 (rank : 53)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	51	Target Neighborhood Hits	388	Shared Neighborhood Hits	13
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

GAS7_HUMAN
NC score	0.129911 (rank : 54)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	51	Target Neighborhood Hits	258	Shared Neighborhood Hits	13
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.129270 (rank : 55)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	51	Target Neighborhood Hits	259	Shared Neighborhood Hits	13
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

K1333_MOUSE
NC score	0.110691 (rank : 56)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	Q5RJY2, Q6ZPT7, Q8BNA4	Gene names	Kiaa1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

PRP40_HUMAN
NC score	0.110000 (rank : 57)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	51	Target Neighborhood Hits	442	Shared Neighborhood Hits	13
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.108946 (rank : 58)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	51	Target Neighborhood Hits	447	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

SRGEF_HUMAN
NC score	0.101492 (rank : 59)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

SRGEF_MOUSE
NC score	0.098260 (rank : 60)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	51	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC2_HUMAN
NC score	0.097243 (rank : 61)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
NC score	0.096546 (rank : 62)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	51	Target Neighborhood Hits	37	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RPGR_HUMAN
NC score	0.095276 (rank : 63)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	51	Target Neighborhood Hits	279	Shared Neighborhood Hits	6
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCC1_HUMAN
NC score	0.093434 (rank : 64)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	51	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

RCC1_MOUSE
NC score	0.091494 (rank : 65)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

WBS16_MOUSE
NC score	0.091365 (rank : 66)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	51	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

RPGR_MOUSE
NC score	0.090297 (rank : 67)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	51	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

WBS16_HUMAN
NC score	0.089384 (rank : 68)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

APBB2_HUMAN
NC score	0.086804 (rank : 69)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	96	Shared Neighborhood Hits	12
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

APBB2_MOUSE
NC score	0.083728 (rank : 70)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

RCBT2_MOUSE
NC score	0.079049 (rank : 71)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	51	Target Neighborhood Hits	156	Shared Neighborhood Hits	6
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

STXB4_HUMAN
NC score	0.078928 (rank : 72)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	51	Target Neighborhood Hits	616	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
NC score	0.078890 (rank : 73)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	51	Target Neighborhood Hits	629	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

RCBT2_HUMAN
NC score	0.078022 (rank : 74)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	51	Target Neighborhood Hits	158	Shared Neighborhood Hits	6
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

FA62A_MOUSE
NC score	0.073706 (rank : 75)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	51	Target Neighborhood Hits	155	Shared Neighborhood Hits	11
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RCBT1_MOUSE
NC score	0.072265 (rank : 76)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	51	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

CUL7_HUMAN
NC score	0.071136 (rank : 77)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	51	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q14999, Q5T654	Gene names	CUL7, KIAA0076
Domain Architecture
Description	Cullin-7 (CUL-7).

UN13B_MOUSE
NC score	0.070380 (rank : 78)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	51	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

RCBT1_HUMAN
NC score	0.070361 (rank : 79)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	51	Target Neighborhood Hits	158	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

UN13B_HUMAN
NC score	0.070346 (rank : 80)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	51	Target Neighborhood Hits	217	Shared Neighborhood Hits	10
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

K1333_HUMAN
NC score	0.068962 (rank : 81)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3	Gene names	KIAA1333
Domain Architecture	No domain graphic available
Description	Protein KIAA1333 (EC 6.3.2.-).

UN13A_HUMAN
NC score	0.067269 (rank : 82)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	51	Target Neighborhood Hits	285	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

SETD2_HUMAN
NC score	0.063290 (rank : 83)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	51	Target Neighborhood Hits	412	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

FA62A_HUMAN
NC score	0.062135 (rank : 84)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	51	Target Neighborhood Hits	168	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

ALS2_HUMAN
NC score	0.061455 (rank : 85)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RASL1_HUMAN
NC score	0.061284 (rank : 86)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	51	Target Neighborhood Hits	142	Shared Neighborhood Hits	7
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RHG12_MOUSE
NC score	0.061002 (rank : 87)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	51	Target Neighborhood Hits	204	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB3_MOUSE
NC score	0.059309 (rank : 88)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R1C9	Gene names	Apbb3
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 3.

ALS2_MOUSE
NC score	0.059303 (rank : 89)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

APBB3_HUMAN
NC score	0.058967 (rank : 90)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	O95704, Q9NYX6, Q9NYX7, Q9NYX8	Gene names	APBB3, FE65L2
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 3 (Fe65-like protein 2) (Fe65L2).

APC10_HUMAN
NC score	0.058953 (rank : 91)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	51	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UM13, Q2V500, Q9UG51, Q9Y5R0	Gene names	ANAPC10, APC10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

RASL1_MOUSE
NC score	0.057886 (rank : 92)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	51	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

APC10_MOUSE
NC score	0.056551 (rank : 93)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K2H6, Q9CW24	Gene names	Anapc10, Apc10
Domain Architecture
Description	Anaphase-promoting complex subunit 10 (APC10) (Cyclosome subunit 10).

WBP4_MOUSE
NC score	0.056410 (rank : 94)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	51	Target Neighborhood Hits	100	Shared Neighborhood Hits	11
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

DOC2A_MOUSE
NC score	0.054892 (rank : 95)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	51	Target Neighborhood Hits	140	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

RASL2_HUMAN
NC score	0.054421 (rank : 96)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	51	Target Neighborhood Hits	161	Shared Neighborhood Hits	7
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

PARC_MOUSE
NC score	0.054139 (rank : 97)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	51	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q80TT8, Q8BKL9, Q8CGC0, Q8R363	Gene names	Parc, Kiaa0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein.

TOLIP_MOUSE
NC score	0.053782 (rank : 98)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	51	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

PARC_HUMAN
NC score	0.053263 (rank : 99)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	51	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

RHG12_HUMAN
NC score	0.052904 (rank : 100)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	51	Target Neighborhood Hits	190	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

DOC2A_HUMAN
NC score	0.052131 (rank : 101)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	51	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

TOLIP_HUMAN
NC score	0.051868 (rank : 102)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	51	Target Neighborhood Hits	20	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

MYCB2_HUMAN
NC score	0.050588 (rank : 103)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	51	Target Neighborhood Hits	390	Shared Neighborhood Hits	7
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

DOC2B_HUMAN
NC score	0.050586 (rank : 104)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	51	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

COG3_HUMAN
NC score	0.044467 (rank : 105)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

IQCB1_HUMAN
NC score	0.034825 (rank : 106)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	60	Shared Neighborhood Hits	6
SwissProt Accessions	Q15051, Q5DKQ7, Q8NI79, Q9BS08	Gene names	IQCB1, KIAA0036, NPHP5
Domain Architecture
Description	IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5).

COG3_MOUSE
NC score	0.028936 (rank : 107)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

IQCB1_MOUSE
NC score	0.023836 (rank : 108)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	81	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BP00, Q3TNK4, Q8K306	Gene names	Iqcb1, Kiaa0036
Domain Architecture	No domain graphic available
Description	IQ calmodulin-binding motif-containing protein 1.

DC1I1_MOUSE
NC score	0.021348 (rank : 109)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	O88485, O88486	Gene names	Dync1i1, Dnci1, Dncic1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

DC1I1_HUMAN
NC score	0.021333 (rank : 110)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	183	Shared Neighborhood Hits	3
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

LBH2_HUMAN
NC score	0.013801 (rank : 111)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P08910	Gene names	ABHD2, LABH2
Domain Architecture
Description	Abhydrolase domain-containing protein 2 (Protein PHPS1-2).

ASPM_HUMAN
NC score	0.011652 (rank : 112)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	197	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

ZWINT_MOUSE
NC score	0.006357 (rank : 113)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	497	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

TRPC2_MOUSE
NC score	0.005751 (rank : 114)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

DDX27_MOUSE
NC score	0.005074 (rank : 115)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	174	Shared Neighborhood Hits	4
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

TITF1_HUMAN
NC score	0.000593 (rank : 116)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	332	Shared Neighborhood Hits	3
SwissProt Accessions	P43699, O14954, O14955, Q9BRJ8	Gene names	TITF1, NKX2-1, NKX2A, TTF1
Domain Architecture
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1) (Homeobox protein NK-2 homolog A).

TITF1_MOUSE
NC score	0.000567 (rank : 117)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	335	Shared Neighborhood Hits	3
SwissProt Accessions	P50220	Gene names	Titf1, Nkx-2.1, Nkx2-1, Ttf1
Domain Architecture	No domain graphic available
Description	Thyroid transcription factor 1 (Thyroid nuclear factor 1) (TTF-1) (Homeobox protein Nkx-2.1).

MYO3A_HUMAN
NC score	-0.000998 (rank : 118)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	1033	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
NC score	-0.001699 (rank : 119)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	902	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

KPCD3_MOUSE
NC score	-0.003682 (rank : 120)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	901	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).