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Network neighborhood for query Sequence : ALS2_MOUSE

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ALS2_MOUSE
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ALS2_HUMAN
θ value	0 (rank : 1)	NC score	0.993643 (rank : 2)
Query Neighborhood Hits	111	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ALS2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	111
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

HERC3_HUMAN
θ value	2.13179e-17 (rank : 3)	NC score	0.413553 (rank : 25)
Query Neighborhood Hits	111	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

TSGA2_HUMAN
θ value	6.85773e-16 (rank : 4)	NC score	0.539833 (rank : 6)
Query Neighborhood Hits	111	Target Neighborhood Hits	40	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYR4	Gene names	TSGA2, TSA2
Domain Architecture
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

HERC2_HUMAN
θ value	1.52774e-15 (rank : 5)	NC score	0.410975 (rank : 27)
Query Neighborhood Hits	111	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	1.52774e-15 (rank : 6)	NC score	0.409578 (rank : 28)
Query Neighborhood Hits	111	Target Neighborhood Hits	167	Shared Neighborhood Hits	29
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

MORN1_HUMAN
θ value	3.40345e-15 (rank : 7)	NC score	0.522197 (rank : 13)
Query Neighborhood Hits	111	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T089, Q8WW30, Q9H852	Gene names	MORN1
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 1.

RCBT1_MOUSE
θ value	2.88119e-14 (rank : 8)	NC score	0.470831 (rank : 20)
Query Neighborhood Hits	111	Target Neighborhood Hits	157	Shared Neighborhood Hits	30
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

MORN3_MOUSE
θ value	1.09485e-13 (rank : 9)	NC score	0.522301 (rank : 12)
Query Neighborhood Hits	111	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C5T4, Q8VE21, Q9D5H6	Gene names	Morn3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

RPGR_MOUSE
θ value	1.09485e-13 (rank : 10)	NC score	0.530443 (rank : 8)
Query Neighborhood Hits	111	Target Neighborhood Hits	281	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

TSGA2_MOUSE
θ value	1.09485e-13 (rank : 11)	NC score	0.522895 (rank : 11)
Query Neighborhood Hits	111	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VIG3, Q9DAL5	Gene names	Tsga2
Domain Architecture	No domain graphic available
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

HERC5_HUMAN
θ value	1.86753e-13 (rank : 12)	NC score	0.402495 (rank : 32)
Query Neighborhood Hits	111	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

RCBT1_HUMAN
θ value	1.86753e-13 (rank : 13)	NC score	0.468412 (rank : 21)
Query Neighborhood Hits	111	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

MORN3_HUMAN
θ value	3.18553e-13 (rank : 14)	NC score	0.518737 (rank : 15)
Query Neighborhood Hits	111	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

RPGR_HUMAN
θ value	3.18553e-13 (rank : 15)	NC score	0.526002 (rank : 9)
Query Neighborhood Hits	111	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCBT2_MOUSE
θ value	9.26847e-13 (rank : 16)	NC score	0.478407 (rank : 18)
Query Neighborhood Hits	111	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCC2_HUMAN
θ value	2.0648e-12 (rank : 17)	NC score	0.566415 (rank : 3)
Query Neighborhood Hits	111	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
θ value	2.69671e-12 (rank : 18)	NC score	0.566375 (rank : 4)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

RCBT2_HUMAN
θ value	6.00763e-12 (rank : 19)	NC score	0.478199 (rank : 19)
Query Neighborhood Hits	111	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

JPH2_HUMAN
θ value	2.98157e-11 (rank : 20)	NC score	0.382619 (rank : 33)
Query Neighborhood Hits	111	Target Neighborhood Hits	639	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH2_MOUSE
θ value	2.98157e-11 (rank : 21)	NC score	0.407928 (rank : 30)
Query Neighborhood Hits	111	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH3_HUMAN
θ value	3.89403e-11 (rank : 22)	NC score	0.422324 (rank : 22)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH3_MOUSE
θ value	3.89403e-11 (rank : 23)	NC score	0.422280 (rank : 23)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH1_MOUSE
θ value	1.9326e-10 (rank : 24)	NC score	0.413582 (rank : 24)
Query Neighborhood Hits	111	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

SRGEF_MOUSE
θ value	2.52405e-10 (rank : 25)	NC score	0.543096 (rank : 5)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

NEK8_HUMAN
θ value	5.62301e-10 (rank : 26)	NC score	0.130074 (rank : 58)
Query Neighborhood Hits	111	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

JPH1_HUMAN
θ value	1.25267e-09 (rank : 27)	NC score	0.411096 (rank : 26)
Query Neighborhood Hits	111	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

NEK8_MOUSE
θ value	1.25267e-09 (rank : 28)	NC score	0.129103 (rank : 60)
Query Neighborhood Hits	111	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

JPH4_HUMAN
θ value	2.79066e-09 (rank : 29)	NC score	0.409448 (rank : 29)
Query Neighborhood Hits	111	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH4_MOUSE
θ value	2.79066e-09 (rank : 30)	NC score	0.406751 (rank : 31)
Query Neighborhood Hits	111	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

SRGEF_HUMAN
θ value	8.11959e-09 (rank : 31)	NC score	0.537892 (rank : 7)
Query Neighborhood Hits	111	Target Neighborhood Hits	33	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RCC1_MOUSE
θ value	1.80886e-08 (rank : 32)	NC score	0.525876 (rank : 10)
Query Neighborhood Hits	111	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

MYCB2_HUMAN
θ value	3.08544e-08 (rank : 33)	NC score	0.334643 (rank : 36)
Query Neighborhood Hits	111	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

RCC1_HUMAN
θ value	1.17247e-07 (rank : 34)	NC score	0.520910 (rank : 14)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

WBS16_HUMAN
θ value	1.17247e-07 (rank : 35)	NC score	0.510561 (rank : 16)
Query Neighborhood Hits	111	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

NEK9_HUMAN
θ value	1.99992e-07 (rank : 36)	NC score	0.129389 (rank : 59)
Query Neighborhood Hits	111	Target Neighborhood Hits	900	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MYCB2_MOUSE
θ value	3.41135e-07 (rank : 37)	NC score	0.329283 (rank : 37)
Query Neighborhood Hits	111	Target Neighborhood Hits	307	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NEK9_MOUSE
θ value	4.45536e-07 (rank : 38)	NC score	0.130113 (rank : 57)
Query Neighborhood Hits	111	Target Neighborhood Hits	890	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

WBS16_MOUSE
θ value	4.45536e-07 (rank : 39)	NC score	0.508186 (rank : 17)
Query Neighborhood Hits	111	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

PKHF2_HUMAN
θ value	8.40245e-06 (rank : 40)	NC score	0.210493 (rank : 42)
Query Neighborhood Hits	111	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.09739e-05 (rank : 41)	NC score	0.208899 (rank : 44)
Query Neighborhood Hits	111	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHG6_HUMAN
θ value	2.44474e-05 (rank : 42)	NC score	0.111366 (rank : 69)
Query Neighborhood Hits	111	Target Neighborhood Hits	376	Shared Neighborhood Hits	15
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD2_MOUSE
θ value	7.1131e-05 (rank : 43)	NC score	0.157472 (rank : 49)
Query Neighborhood Hits	111	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD6_HUMAN
θ value	9.29e-05 (rank : 44)	NC score	0.158432 (rank : 47)
Query Neighborhood Hits	111	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FARP1_HUMAN
θ value	0.000121331 (rank : 45)	NC score	0.115022 (rank : 67)
Query Neighborhood Hits	111	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PKHF1_MOUSE
θ value	0.000158464 (rank : 46)	NC score	0.198089 (rank : 45)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHG6_MOUSE
θ value	0.00020696 (rank : 47)	NC score	0.101968 (rank : 73)
Query Neighborhood Hits	111	Target Neighborhood Hits	394	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ANKY1_HUMAN
θ value	0.000270298 (rank : 48)	NC score	0.210171 (rank : 43)
Query Neighborhood Hits	111	Target Neighborhood Hits	248	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

FGD6_MOUSE
θ value	0.000270298 (rank : 49)	NC score	0.157684 (rank : 48)
Query Neighborhood Hits	111	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PKHF1_HUMAN
θ value	0.000461057 (rank : 50)	NC score	0.191918 (rank : 46)
Query Neighborhood Hits	111	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RIN3_MOUSE
θ value	0.00102713 (rank : 51)	NC score	0.139444 (rank : 52)
Query Neighborhood Hits	111	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN3_HUMAN
θ value	0.00228821 (rank : 52)	NC score	0.137665 (rank : 53)
Query Neighborhood Hits	111	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN2_HUMAN
θ value	0.00390308 (rank : 53)	NC score	0.135463 (rank : 54)
Query Neighborhood Hits	111	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

RIN2_MOUSE
θ value	0.00390308 (rank : 54)	NC score	0.134309 (rank : 56)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

ARHGA_HUMAN
θ value	0.00665767 (rank : 55)	NC score	0.112216 (rank : 68)
Query Neighborhood Hits	111	Target Neighborhood Hits	187	Shared Neighborhood Hits	19
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MORN2_HUMAN
θ value	0.00665767 (rank : 56)	NC score	0.368624 (rank : 34)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q502X0, Q6UL00	Gene names	MORN2, MOPT
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

VAV2_HUMAN
θ value	0.00869519 (rank : 57)	NC score	0.076104 (rank : 79)
Query Neighborhood Hits	111	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

FGD2_HUMAN
θ value	0.0113563 (rank : 58)	NC score	0.140296 (rank : 50)
Query Neighborhood Hits	111	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

VAV2_MOUSE
θ value	0.0113563 (rank : 59)	NC score	0.072159 (rank : 82)
Query Neighborhood Hits	111	Target Neighborhood Hits	456	Shared Neighborhood Hits	19
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

FARP2_MOUSE
θ value	0.0148317 (rank : 60)	NC score	0.107001 (rank : 71)
Query Neighborhood Hits	111	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FBX24_HUMAN
θ value	0.0148317 (rank : 61)	NC score	0.244277 (rank : 38)
Query Neighborhood Hits	111	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

MORN2_MOUSE
θ value	0.0148317 (rank : 62)	NC score	0.350920 (rank : 35)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UL01	Gene names	Morn2, Mopt
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

FGD3_MOUSE
θ value	0.0252991 (rank : 63)	NC score	0.126173 (rank : 61)
Query Neighborhood Hits	111	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RABX5_HUMAN
θ value	0.0252991 (rank : 64)	NC score	0.119802 (rank : 63)
Query Neighborhood Hits	111	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UJ41	Gene names	RABGEF1, RABEX5
Domain Architecture
Description	Rab5 GDP/GTP exchange factor (Rabex-5) (Rabaptin-5-associated exchange factor for Rab5).

RABX5_MOUSE
θ value	0.0252991 (rank : 65)	NC score	0.140202 (rank : 51)
Query Neighborhood Hits	111	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM13, Q3UIW0	Gene names	Rabgef1, Rabex5
Domain Architecture
Description	Rab5 GDP/GTP exchange factor (Rabex-5).

SETD7_HUMAN
θ value	0.0252991 (rank : 66)	NC score	0.228579 (rank : 40)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

SETD7_MOUSE
θ value	0.0252991 (rank : 67)	NC score	0.228766 (rank : 39)
Query Neighborhood Hits	111	Target Neighborhood Hits	39	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

FBX24_MOUSE
θ value	0.0563607 (rank : 68)	NC score	0.220335 (rank : 41)
Query Neighborhood Hits	111	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

OGT1_HUMAN
θ value	0.0961366 (rank : 69)	NC score	0.046099 (rank : 126)
Query Neighborhood Hits	111	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

FGD3_HUMAN
θ value	0.125558 (rank : 70)	NC score	0.116375 (rank : 66)
Query Neighborhood Hits	111	Target Neighborhood Hits	249	Shared Neighborhood Hits	20
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_MOUSE
θ value	0.163984 (rank : 71)	NC score	0.134543 (rank : 55)
Query Neighborhood Hits	111	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

ARHGA_MOUSE
θ value	0.21417 (rank : 72)	NC score	0.098787 (rank : 74)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FGD1_HUMAN
θ value	0.21417 (rank : 73)	NC score	0.123219 (rank : 62)
Query Neighborhood Hits	111	Target Neighborhood Hits	367	Shared Neighborhood Hits	26
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0.365318 (rank : 74)	NC score	0.116870 (rank : 65)
Query Neighborhood Hits	111	Target Neighborhood Hits	387	Shared Neighborhood Hits	25
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

CP007_MOUSE
θ value	0.47712 (rank : 75)	NC score	0.072473 (rank : 81)
Query Neighborhood Hits	111	Target Neighborhood Hits	231	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

TR11B_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.030243 (rank : 127)
Query Neighborhood Hits	111	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O08712, O70202	Gene names	Tnfrsf11b, Ocif, Opg
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

KLH14_HUMAN
θ value	0.62314 (rank : 77)	NC score	0.014514 (rank : 143)
Query Neighborhood Hits	111	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2G3	Gene names	KLHL14, KIAA1384
Domain Architecture	No domain graphic available
Description	Kelch-like protein 14.

SNX1_HUMAN
θ value	1.06291 (rank : 78)	NC score	0.028557 (rank : 129)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

MYO10_HUMAN
θ value	1.81305 (rank : 79)	NC score	0.008245 (rank : 154)
Query Neighborhood Hits	111	Target Neighborhood Hits	920	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

GP112_HUMAN
θ value	2.36792 (rank : 80)	NC score	0.008550 (rank : 153)
Query Neighborhood Hits	111	Target Neighborhood Hits	441	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

CENA1_HUMAN
θ value	3.0926 (rank : 81)	NC score	0.025002 (rank : 130)
Query Neighborhood Hits	111	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CSMD2_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.005371 (rank : 159)
Query Neighborhood Hits	111	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

HCFC1_HUMAN
θ value	3.0926 (rank : 83)	NC score	0.017201 (rank : 137)
Query Neighborhood Hits	111	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCFC1_MOUSE
θ value	3.0926 (rank : 84)	NC score	0.017376 (rank : 136)
Query Neighborhood Hits	111	Target Neighborhood Hits	348	Shared Neighborhood Hits	6
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

PK3CD_MOUSE
θ value	3.0926 (rank : 85)	NC score	0.011297 (rank : 149)
Query Neighborhood Hits	111	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

ATR_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.015016 (rank : 141)
Query Neighborhood Hits	111	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

E2AK4_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.012509 (rank : 145)
Query Neighborhood Hits	111	Target Neighborhood Hits	984	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

HEY2_MOUSE
θ value	4.03905 (rank : 88)	NC score	0.011995 (rank : 146)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

PLEK_HUMAN
θ value	4.03905 (rank : 89)	NC score	0.028667 (rank : 128)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CEND1_HUMAN
θ value	5.27518 (rank : 90)	NC score	0.017891 (rank : 135)
Query Neighborhood Hits	111	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

KLHL3_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.008962 (rank : 152)
Query Neighborhood Hits	111	Target Neighborhood Hits	187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UH77, Q9UH75, Q9UH76, Q9ULU0, Q9Y6V6	Gene names	KLHL3, KIAA1129
Domain Architecture
Description	Kelch-like protein 3.

MARK2_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.010091 (rank : 150)
Query Neighborhood Hits	111	Target Neighborhood Hits	1018	Shared Neighborhood Hits	9
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

PDLI1_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.005910 (rank : 158)
Query Neighborhood Hits	111	Target Neighborhood Hits	242	Shared Neighborhood Hits	2
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PKHA1_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.024487 (rank : 131)
Query Neighborhood Hits	111	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ATBF1_MOUSE
θ value	6.88961 (rank : 95)	NC score	-0.001744 (rank : 162)
Query Neighborhood Hits	111	Target Neighborhood Hits	1841	Shared Neighborhood Hits	7
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CENA2_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.017934 (rank : 134)
Query Neighborhood Hits	111	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

K0406_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.011444 (rank : 148)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

MLL3_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.005340 (rank : 160)
Query Neighborhood Hits	111	Target Neighborhood Hits	1644	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

POPD2_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.022614 (rank : 132)
Query Neighborhood Hits	111	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBU9, Q86UE7	Gene names	POPDC2, POP2
Domain Architecture
Description	Popeye domain-containing protein 2 (Popeye protein 2).

PRAX_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.007359 (rank : 157)
Query Neighborhood Hits	111	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

CCNB3_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.003688 (rank : 161)
Query Neighborhood Hits	111	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

CEND1_MOUSE
θ value	8.99809 (rank : 102)	NC score	0.015470 (rank : 140)
Query Neighborhood Hits	111	Target Neighborhood Hits	260	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

DKC1_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.009793 (rank : 151)
Query Neighborhood Hits	111	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O60832, O43845, Q96G67, Q9Y505	Gene names	DKC1, NOLA4
Domain Architecture
Description	H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (Nopp140- associated protein of 57 kDa) (Nucleolar protein NAP57) (CBF5 homolog).

LPIN2_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.016133 (rank : 138)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

LPIN2_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.015679 (rank : 139)
Query Neighborhood Hits	111	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

MAML3_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.008070 (rank : 156)
Query Neighborhood Hits	111	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

PANK4_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.022441 (rank : 133)
Query Neighborhood Hits	111	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVE7, Q53EU3, Q5TA84, Q7RTX3, Q9H3X5	Gene names	PANK4
Domain Architecture
Description	Pantothenate kinase 4 (EC 2.7.1.33) (Pantothenic acid kinase 4) (hPanK4).

PKCB1_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.011837 (rank : 147)
Query Neighborhood Hits	111	Target Neighborhood Hits	488	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

R113A_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.008244 (rank : 155)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

VKGC_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.014476 (rank : 144)
Query Neighborhood Hits	111	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P38435, Q14415, Q6GU45	Gene names	GGCX, GC
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

VKGC_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.014577 (rank : 142)
Query Neighborhood Hits	111	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYC7, Q3UXN5, Q8CCB3	Gene names	Ggcx
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

ARHG4_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.063997 (rank : 93)
Query Neighborhood Hits	111	Target Neighborhood Hits	242	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.065499 (rank : 91)
Query Neighborhood Hits	111	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.051662 (rank : 120)
Query Neighborhood Hits	111	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG7_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.065191 (rank : 92)
Query Neighborhood Hits	111	Target Neighborhood Hits	347	Shared Neighborhood Hits	18
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.060795 (rank : 96)
Query Neighborhood Hits	111	Target Neighborhood Hits	396	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG9_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.056996 (rank : 105)
Query Neighborhood Hits	111	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.056533 (rank : 106)
Query Neighborhood Hits	111	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ECT2_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.065910 (rank : 90)
Query Neighborhood Hits	111	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.066911 (rank : 89)
Query Neighborhood Hits	111	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP2_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.087615 (rank : 75)
Query Neighborhood Hits	111	Target Neighborhood Hits	240	Shared Neighborhood Hits	26
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.119702 (rank : 64)
Query Neighborhood Hits	111	Target Neighborhood Hits	219	Shared Neighborhood Hits	25
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD5_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.107637 (rank : 70)
Query Neighborhood Hits	111	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.106697 (rank : 72)
Query Neighborhood Hits	111	Target Neighborhood Hits	170	Shared Neighborhood Hits	21
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GNRP_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.050288 (rank : 123)
Query Neighborhood Hits	111	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.052682 (rank : 118)
Query Neighborhood Hits	111	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HECD2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.070181 (rank : 85)
Query Neighborhood Hits	111	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.069274 (rank : 86)
Query Neighborhood Hits	111	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.079897 (rank : 77)
Query Neighborhood Hits	111	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.079906 (rank : 76)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HUWE1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.055435 (rank : 108)
Query Neighborhood Hits	111	Target Neighborhood Hits	443	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.056119 (rank : 107)
Query Neighborhood Hits	111	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITCH_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.053181 (rank : 114)
Query Neighborhood Hits	111	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.053536 (rank : 113)
Query Neighborhood Hits	111	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

KR202_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.057146 (rank : 104)
Query Neighborhood Hits	111	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q3LI61	Gene names	KRTAP20-2, KAP20.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 20-2.

LORI_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.073581 (rank : 80)
Query Neighborhood Hits	111	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P23490	Gene names	LOR, LRN
Domain Architecture	No domain graphic available
Description	Loricrin.

LORI_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.067412 (rank : 88)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	P18165, Q8R0I9	Gene names	Lor
Domain Architecture	No domain graphic available
Description	Loricrin.

MCF2_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.050082 (rank : 125)
Query Neighborhood Hits	111	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NGEF_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.052048 (rank : 119)
Query Neighborhood Hits	111	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.050128 (rank : 124)
Query Neighborhood Hits	111	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHG1_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.068120 (rank : 87)
Query Neighborhood Hits	111	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PREX1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.076565 (rank : 78)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RIN1_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.058954 (rank : 101)
Query Neighborhood Hits	111	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

RIN1_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.059971 (rank : 97)
Query Neighborhood Hits	111	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

SMUF1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.054315 (rank : 111)
Query Neighborhood Hits	111	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.054044 (rank : 112)
Query Neighborhood Hits	111	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.054377 (rank : 110)
Query Neighborhood Hits	111	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

TRIPC_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.061450 (rank : 95)
Query Neighborhood Hits	111	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.071376 (rank : 83)
Query Neighborhood Hits	111	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.071045 (rank : 84)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.059303 (rank : 98)
Query Neighborhood Hits	111	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.059126 (rank : 99)
Query Neighborhood Hits	111	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWP1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.050586 (rank : 122)
Query Neighborhood Hits	111	Target Neighborhood Hits	262	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.050949 (rank : 121)
Query Neighborhood Hits	111	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.052888 (rank : 117)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.053052 (rank : 116)
Query Neighborhood Hits	111	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

ZFY16_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.053169 (rank : 115)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.054869 (rank : 109)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.057552 (rank : 103)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.058666 (rank : 102)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.063412 (rank : 94)
Query Neighborhood Hits	111	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.058957 (rank : 100)
Query Neighborhood Hits	111	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

ALS2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	111
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.993643 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	111	Target Neighborhood Hits	121	Shared Neighborhood Hits	90
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

RCC2_HUMAN
NC score	0.566415 (rank : 3)	θ value	2.0648e-12 (rank : 17)
Query Neighborhood Hits	111	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	Q9P258, Q8IVL9, Q9BSN6, Q9NPV8	Gene names	RCC2, KIAA1470, TD60
Domain Architecture	No domain graphic available
Description	Protein RCC2 (Telophase disk protein of 60 kDa) (RCC1-like protein TD- 60).

RCC2_MOUSE
NC score	0.566375 (rank : 4)	θ value	2.69671e-12 (rank : 18)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BK67, Q6ZPQ0	Gene names	Rcc2, Kiaa1470
Domain Architecture	No domain graphic available
Description	Protein RCC2.

SRGEF_MOUSE
NC score	0.543096 (rank : 5)	θ value	2.52405e-10 (rank : 25)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	28
SwissProt Accessions	Q80YD6, Q9QXB7	Gene names	Sergef, Delgef, Gnefr
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

TSGA2_HUMAN
NC score	0.539833 (rank : 6)	θ value	6.85773e-16 (rank : 4)
Query Neighborhood Hits	111	Target Neighborhood Hits	40	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYR4	Gene names	TSGA2, TSA2
Domain Architecture
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

SRGEF_HUMAN
NC score	0.537892 (rank : 7)	θ value	8.11959e-09 (rank : 31)
Query Neighborhood Hits	111	Target Neighborhood Hits	33	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UGK8, Q9UGK9	Gene names	SERGEF, DELGEF, GNEFR
Domain Architecture	No domain graphic available
Description	Secretion-regulating guanine nucleotide exchange factor (Guanine nucleotide exchange factor-related protein) (Deafness locus-associated putative guanine nucleotide exchange factor) (DelGEF).

RPGR_MOUSE
NC score	0.530443 (rank : 8)	θ value	1.09485e-13 (rank : 10)
Query Neighborhood Hits	111	Target Neighborhood Hits	281	Shared Neighborhood Hits	29
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

RPGR_HUMAN
NC score	0.526002 (rank : 9)	θ value	3.18553e-13 (rank : 15)
Query Neighborhood Hits	111	Target Neighborhood Hits	279	Shared Neighborhood Hits	28
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RCC1_MOUSE
NC score	0.525876 (rank : 10)	θ value	1.80886e-08 (rank : 32)
Query Neighborhood Hits	111	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	Q8VE37, Q3UDB6	Gene names	Rcc1, Chc1
Domain Architecture	No domain graphic available
Description	Regulator of chromosome condensation (Chromosome condensation protein 1).

TSGA2_MOUSE
NC score	0.522895 (rank : 11)	θ value	1.09485e-13 (rank : 11)
Query Neighborhood Hits	111	Target Neighborhood Hits	26	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VIG3, Q9DAL5	Gene names	Tsga2
Domain Architecture	No domain graphic available
Description	Testis-specific gene A2 protein (Male meiotic metaphase chromosome- associated acidic protein) (Meichroacidin).

MORN3_MOUSE
NC score	0.522301 (rank : 12)	θ value	1.09485e-13 (rank : 9)
Query Neighborhood Hits	111	Target Neighborhood Hits	25	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C5T4, Q8VE21, Q9D5H6	Gene names	Morn3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

MORN1_HUMAN
NC score	0.522197 (rank : 13)	θ value	3.40345e-15 (rank : 7)
Query Neighborhood Hits	111	Target Neighborhood Hits	89	Shared Neighborhood Hits	20
SwissProt Accessions	Q5T089, Q8WW30, Q9H852	Gene names	MORN1
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 1.

RCC1_HUMAN
NC score	0.520910 (rank : 14)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P18754	Gene names	RCC1, CHC1
Domain Architecture
Description	Regulator of chromosome condensation (Chromosome condensation protein 1) (Cell cycle regulatory protein).

MORN3_HUMAN
NC score	0.518737 (rank : 15)	θ value	3.18553e-13 (rank : 14)
Query Neighborhood Hits	111	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q6PF18, Q86YQ9	Gene names	MORN3
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 3.

WBS16_HUMAN
NC score	0.510561 (rank : 16)	θ value	1.17247e-07 (rank : 35)
Query Neighborhood Hits	111	Target Neighborhood Hits	29	Shared Neighborhood Hits	28
SwissProt Accessions	Q96I51, Q548B1, Q9H0G7	Gene names	WBSCR16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein (RCC1-like G exchanging factor-like protein).

WBS16_MOUSE
NC score	0.508186 (rank : 17)	θ value	4.45536e-07 (rank : 39)
Query Neighborhood Hits	111	Target Neighborhood Hits	31	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CYF5	Gene names	Wbscr16
Domain Architecture	No domain graphic available
Description	Williams-Beuren syndrome chromosome region 16 protein homolog.

RCBT2_MOUSE
NC score	0.478407 (rank : 18)	θ value	9.26847e-13 (rank : 16)
Query Neighborhood Hits	111	Target Neighborhood Hits	156	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LJ7, Q3TUA3, Q8BMG2	Gene names	Rcbtb2, Chc1l
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like).

RCBT2_HUMAN
NC score	0.478199 (rank : 19)	θ value	6.00763e-12 (rank : 19)
Query Neighborhood Hits	111	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	O95199	Gene names	RCBTB2, CHC1L, RLG
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 2 (Regulator of chromosome condensation and BTB domain-containing protein 2) (Chromosome condensation 1-like) (CHC1-L) (RCC1-like G exchanging factor).

RCBT1_MOUSE
NC score	0.470831 (rank : 20)	θ value	2.88119e-14 (rank : 8)
Query Neighborhood Hits	111	Target Neighborhood Hits	157	Shared Neighborhood Hits	30
SwissProt Accessions	Q6NXM2, Q8BTZ6, Q8BZV0	Gene names	Rcbtb1
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1).

RCBT1_HUMAN
NC score	0.468412 (rank : 21)	θ value	1.86753e-13 (rank : 13)
Query Neighborhood Hits	111	Target Neighborhood Hits	158	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NDN9, Q969U9	Gene names	RCBTB1, CLLD7, E4.5
Domain Architecture	No domain graphic available
Description	RCC1 and BTB domain-containing protein 1 (Regulator of chromosome condensation and BTB domain-containing protein 1) (Chronic lymphocytic leukemia deletion region gene 7 protein) (CLL deletion region gene 7 protein).

JPH3_HUMAN
NC score	0.422324 (rank : 22)	θ value	3.89403e-11 (rank : 22)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXH2, Q8N471, Q9HDC3, Q9HDC4	Gene names	JPH3, JP3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH3_MOUSE
NC score	0.422280 (rank : 23)	θ value	3.89403e-11 (rank : 23)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9ET77, Q9EQZ2	Gene names	Jph3, Jp3
Domain Architecture
Description	Junctophilin-3 (Junctophilin type 3) (JP-3).

JPH1_MOUSE
NC score	0.413582 (rank : 24)	θ value	1.9326e-10 (rank : 24)
Query Neighborhood Hits	111	Target Neighborhood Hits	120	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

HERC3_HUMAN
NC score	0.413553 (rank : 25)	θ value	2.13179e-17 (rank : 3)
Query Neighborhood Hits	111	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

JPH1_HUMAN
NC score	0.411096 (rank : 26)	θ value	1.25267e-09 (rank : 27)
Query Neighborhood Hits	111	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9HDC5	Gene names	JPH1, JP1
Domain Architecture	No domain graphic available
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

HERC2_HUMAN
NC score	0.410975 (rank : 27)	θ value	1.52774e-15 (rank : 5)
Query Neighborhood Hits	111	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
NC score	0.409578 (rank : 28)	θ value	1.52774e-15 (rank : 6)
Query Neighborhood Hits	111	Target Neighborhood Hits	167	Shared Neighborhood Hits	29
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

JPH4_HUMAN
NC score	0.409448 (rank : 29)	θ value	2.79066e-09 (rank : 29)
Query Neighborhood Hits	111	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q96JJ6, Q8ND44, Q96DQ0	Gene names	JPH4, JPHL1, KIAA1831
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

JPH2_MOUSE
NC score	0.407928 (rank : 30)	θ value	2.98157e-11 (rank : 21)
Query Neighborhood Hits	111	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

JPH4_MOUSE
NC score	0.406751 (rank : 31)	θ value	2.79066e-09 (rank : 30)
Query Neighborhood Hits	111	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	Q80WT0, Q8BMI1	Gene names	Jph4, Jphl1
Domain Architecture	No domain graphic available
Description	Junctophilin-4 (Junctophilin-like 1 protein).

HERC5_HUMAN
NC score	0.402495 (rank : 32)	θ value	1.86753e-13 (rank : 12)
Query Neighborhood Hits	111	Target Neighborhood Hits	66	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

JPH2_HUMAN
NC score	0.382619 (rank : 33)	θ value	2.98157e-11 (rank : 20)
Query Neighborhood Hits	111	Target Neighborhood Hits	639	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

MORN2_HUMAN
NC score	0.368624 (rank : 34)	θ value	0.00665767 (rank : 56)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q502X0, Q6UL00	Gene names	MORN2, MOPT
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

MORN2_MOUSE
NC score	0.350920 (rank : 35)	θ value	0.0148317 (rank : 62)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	Q6UL01	Gene names	Morn2, Mopt
Domain Architecture	No domain graphic available
Description	MORN repeat-containing protein 2 (MORN motif protein in testis).

MYCB2_HUMAN
NC score	0.334643 (rank : 36)	θ value	3.08544e-08 (rank : 33)
Query Neighborhood Hits	111	Target Neighborhood Hits	390	Shared Neighborhood Hits	34
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYCB2_MOUSE
NC score	0.329283 (rank : 37)	θ value	3.41135e-07 (rank : 37)
Query Neighborhood Hits	111	Target Neighborhood Hits	307	Shared Neighborhood Hits	31
SwissProt Accessions	Q7TPH6, Q6PCM8	Gene names	Mycbp2, Pam, Phr1
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

FBX24_HUMAN
NC score	0.244277 (rank : 38)	θ value	0.0148317 (rank : 61)
Query Neighborhood Hits	111	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	O75426, Q9H0G1	Gene names	FBXO24, FBX24
Domain Architecture
Description	F-box only protein 24.

SETD7_MOUSE
NC score	0.228766 (rank : 39)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	111	Target Neighborhood Hits	39	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VHL1	Gene names	Setd7, Set7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7).

SETD7_HUMAN
NC score	0.228579 (rank : 40)	θ value	0.0252991 (rank : 66)
Query Neighborhood Hits	111	Target Neighborhood Hits	37	Shared Neighborhood Hits	21
SwissProt Accessions	Q8WTS6, Q9C0E6	Gene names	SETD7, KIAA1717, SET7
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7 (EC 2.1.1.43) (Histone H3-K4 methyltransferase) (H3-K4-HMTase) (SET domain-containing protein 7) (Set9) (SET7/9).

FBX24_MOUSE
NC score	0.220335 (rank : 41)	θ value	0.0563607 (rank : 68)
Query Neighborhood Hits	111	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D417	Gene names	Fbxo24, Fbx24
Domain Architecture	No domain graphic available
Description	F-box only protein 24.

PKHF2_HUMAN
NC score	0.210493 (rank : 42)	θ value	8.40245e-06 (rank : 40)
Query Neighborhood Hits	111	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ANKY1_HUMAN
NC score	0.210171 (rank : 43)	θ value	0.000270298 (rank : 48)
Query Neighborhood Hits	111	Target Neighborhood Hits	248	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

PKHF2_MOUSE
NC score	0.208899 (rank : 44)	θ value	1.09739e-05 (rank : 41)
Query Neighborhood Hits	111	Target Neighborhood Hits	77	Shared Neighborhood Hits	20
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.198089 (rank : 45)	θ value	0.000158464 (rank : 46)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.191918 (rank : 46)	θ value	0.000461057 (rank : 50)
Query Neighborhood Hits	111	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

FGD6_HUMAN
NC score	0.158432 (rank : 47)	θ value	9.29e-05 (rank : 44)
Query Neighborhood Hits	111	Target Neighborhood Hits	237	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.157684 (rank : 48)	θ value	0.000270298 (rank : 49)
Query Neighborhood Hits	111	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD2_MOUSE
NC score	0.157472 (rank : 49)	θ value	7.1131e-05 (rank : 43)
Query Neighborhood Hits	111	Target Neighborhood Hits	163	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.140296 (rank : 50)	θ value	0.0113563 (rank : 58)
Query Neighborhood Hits	111	Target Neighborhood Hits	151	Shared Neighborhood Hits	24
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

RABX5_MOUSE
NC score	0.140202 (rank : 51)	θ value	0.0252991 (rank : 65)
Query Neighborhood Hits	111	Target Neighborhood Hits	39	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM13, Q3UIW0	Gene names	Rabgef1, Rabex5
Domain Architecture
Description	Rab5 GDP/GTP exchange factor (Rabex-5).

RIN3_MOUSE
NC score	0.139444 (rank : 52)	θ value	0.00102713 (rank : 51)
Query Neighborhood Hits	111	Target Neighborhood Hits	239	Shared Neighborhood Hits	11
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN3_HUMAN
NC score	0.137665 (rank : 53)	θ value	0.00228821 (rank : 52)
Query Neighborhood Hits	111	Target Neighborhood Hits	227	Shared Neighborhood Hits	10
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIN2_HUMAN
NC score	0.135463 (rank : 54)	θ value	0.00390308 (rank : 53)
Query Neighborhood Hits	111	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WYP3, Q00425, Q5TFT8, Q9BQL3, Q9H071	Gene names	RIN2, RASSF4
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2) (Ras inhibitor JC265) (Ras association domain family 4).

FGD4_MOUSE
NC score	0.134543 (rank : 55)	θ value	0.163984 (rank : 71)
Query Neighborhood Hits	111	Target Neighborhood Hits	227	Shared Neighborhood Hits	26
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

RIN2_MOUSE
NC score	0.134309 (rank : 56)	θ value	0.00390308 (rank : 54)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D684, Q99K06	Gene names	Rin2
Domain Architecture
Description	Ras and Rab interactor 2 (Ras interaction/interference protein 2).

NEK9_MOUSE
NC score	0.130113 (rank : 57)	θ value	4.45536e-07 (rank : 38)
Query Neighborhood Hits	111	Target Neighborhood Hits	890	Shared Neighborhood Hits	31
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK8_HUMAN
NC score	0.130074 (rank : 58)	θ value	5.62301e-10 (rank : 26)
Query Neighborhood Hits	111	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK9_HUMAN
NC score	0.129389 (rank : 59)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	111	Target Neighborhood Hits	900	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK8_MOUSE
NC score	0.129103 (rank : 60)	θ value	1.25267e-09 (rank : 28)
Query Neighborhood Hits	111	Target Neighborhood Hits	872	Shared Neighborhood Hits	30
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

FGD3_MOUSE
NC score	0.126173 (rank : 61)	θ value	0.0252991 (rank : 63)
Query Neighborhood Hits	111	Target Neighborhood Hits	257	Shared Neighborhood Hits	22
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD1_HUMAN
NC score	0.123219 (rank : 62)	θ value	0.21417 (rank : 73)
Query Neighborhood Hits	111	Target Neighborhood Hits	367	Shared Neighborhood Hits	26
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RABX5_HUMAN
NC score	0.119802 (rank : 63)	θ value	0.0252991 (rank : 64)
Query Neighborhood Hits	111	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UJ41	Gene names	RABGEF1, RABEX5
Domain Architecture
Description	Rab5 GDP/GTP exchange factor (Rabex-5) (Rabaptin-5-associated exchange factor for Rab5).

FGD4_HUMAN
NC score	0.119702 (rank : 64)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	111	Target Neighborhood Hits	219	Shared Neighborhood Hits	25
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD1_MOUSE
NC score	0.116870 (rank : 65)	θ value	0.365318 (rank : 74)
Query Neighborhood Hits	111	Target Neighborhood Hits	387	Shared Neighborhood Hits	25
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
NC score	0.116375 (rank : 66)	θ value	0.125558 (rank : 70)
Query Neighborhood Hits	111	Target Neighborhood Hits	249	Shared Neighborhood Hits	20
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FARP1_HUMAN
NC score	0.115022 (rank : 67)	θ value	0.000121331 (rank : 45)
Query Neighborhood Hits	111	Target Neighborhood Hits	241	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ARHGA_HUMAN
NC score	0.112216 (rank : 68)	θ value	0.00665767 (rank : 55)
Query Neighborhood Hits	111	Target Neighborhood Hits	187	Shared Neighborhood Hits	19
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHG6_HUMAN
NC score	0.111366 (rank : 69)	θ value	2.44474e-05 (rank : 42)
Query Neighborhood Hits	111	Target Neighborhood Hits	376	Shared Neighborhood Hits	15
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD5_HUMAN
NC score	0.107637 (rank : 70)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	111	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FARP2_MOUSE
NC score	0.107001 (rank : 71)	θ value	0.0148317 (rank : 60)
Query Neighborhood Hits	111	Target Neighborhood Hits	209	Shared Neighborhood Hits	28
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD5_MOUSE
NC score	0.106697 (rank : 72)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	111	Target Neighborhood Hits	170	Shared Neighborhood Hits	21
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ARHG6_MOUSE
NC score	0.101968 (rank : 73)	θ value	0.00020696 (rank : 47)
Query Neighborhood Hits	111	Target Neighborhood Hits	394	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGA_MOUSE
NC score	0.098787 (rank : 74)	θ value	0.21417 (rank : 72)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	19
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

FARP2_HUMAN
NC score	0.087615 (rank : 75)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	111	Target Neighborhood Hits	240	Shared Neighborhood Hits	26
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

HECD3_MOUSE
NC score	0.079906 (rank : 76)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_HUMAN
NC score	0.079897 (rank : 77)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	111	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

PREX1_HUMAN
NC score	0.076565 (rank : 78)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

VAV2_HUMAN
NC score	0.076104 (rank : 79)	θ value	0.00869519 (rank : 57)
Query Neighborhood Hits	111	Target Neighborhood Hits	453	Shared Neighborhood Hits	21
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

LORI_HUMAN
NC score	0.073581 (rank : 80)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	111	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	P23490	Gene names	LOR, LRN
Domain Architecture	No domain graphic available
Description	Loricrin.

CP007_MOUSE
NC score	0.072473 (rank : 81)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	111	Target Neighborhood Hits	231	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C190, Q6PFD1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 homolog (5-day ovary-specific transcript 1 protein).

VAV2_MOUSE
NC score	0.072159 (rank : 82)	θ value	0.0113563 (rank : 59)
Query Neighborhood Hits	111	Target Neighborhood Hits	456	Shared Neighborhood Hits	19
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

UBE3A_HUMAN
NC score	0.071376 (rank : 83)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	111	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
NC score	0.071045 (rank : 84)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

HECD2_HUMAN
NC score	0.070181 (rank : 85)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	111	Target Neighborhood Hits	41	Shared Neighborhood Hits	4
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
NC score	0.069274 (rank : 86)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	111	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

PKHG1_HUMAN
NC score	0.068120 (rank : 87)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	111	Target Neighborhood Hits	174	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

LORI_MOUSE
NC score	0.067412 (rank : 88)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	111	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	P18165, Q8R0I9	Gene names	Lor
Domain Architecture	No domain graphic available
Description	Loricrin.

ECT2_MOUSE
NC score	0.066911 (rank : 89)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	111	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.065910 (rank : 90)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	111	Target Neighborhood Hits	98	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG4_MOUSE
NC score	0.065499 (rank : 91)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	111	Target Neighborhood Hits	185	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG7_HUMAN
NC score	0.065191 (rank : 92)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	111	Target Neighborhood Hits	347	Shared Neighborhood Hits	18
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG4_HUMAN
NC score	0.063997 (rank : 93)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	111	Target Neighborhood Hits	242	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ZFY28_HUMAN
NC score	0.063412 (rank : 94)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	111	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

TRIPC_HUMAN
NC score	0.061450 (rank : 95)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	111	Target Neighborhood Hits	319	Shared Neighborhood Hits	8
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

ARHG7_MOUSE
NC score	0.060795 (rank : 96)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	111	Target Neighborhood Hits	396	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

RIN1_MOUSE
NC score	0.059971 (rank : 97)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	111	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q921Q7	Gene names	Rin1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1).

UBE3C_HUMAN
NC score	0.059303 (rank : 98)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	111	Target Neighborhood Hits	51	Shared Neighborhood Hits	4
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.059126 (rank : 99)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	111	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

ZFYV9_HUMAN
NC score	0.058957 (rank : 100)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	111	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

RIN1_HUMAN
NC score	0.058954 (rank : 101)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	111	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q13671, O15010, Q00427, Q96CC8	Gene names	RIN1
Domain Architecture
Description	Ras and Rab interactor 1 (Ras interaction/interference protein 1) (Ras inhibitor JC99).

ZFY21_MOUSE
NC score	0.058666 (rank : 102)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.057552 (rank : 103)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	111	Target Neighborhood Hits	72	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

KR202_HUMAN
NC score	0.057146 (rank : 104)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	111	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q3LI61	Gene names	KRTAP20-2, KAP20.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 20-2.

ARHG9_HUMAN
NC score	0.056996 (rank : 105)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	111	Target Neighborhood Hits	235	Shared Neighborhood Hits	17
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.056533 (rank : 106)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	111	Target Neighborhood Hits	234	Shared Neighborhood Hits	17
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

HUWE1_MOUSE
NC score	0.056119 (rank : 107)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	111	Target Neighborhood Hits	406	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.055435 (rank : 108)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	111	Target Neighborhood Hits	443	Shared Neighborhood Hits	10
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

ZFY16_MOUSE
NC score	0.054869 (rank : 109)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

SMUF2_HUMAN
NC score	0.054377 (rank : 110)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	111	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.054315 (rank : 111)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	111	Target Neighborhood Hits	135	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.054044 (rank : 112)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	111	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

ITCH_MOUSE
NC score	0.053536 (rank : 113)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	111	Target Neighborhood Hits	127	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.053181 (rank : 114)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	111	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ZFY16_HUMAN
NC score	0.053169 (rank : 115)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

WWP2_MOUSE
NC score	0.053052 (rank : 116)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	111	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.052888 (rank : 117)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

GNRP_MOUSE
NC score	0.052682 (rank : 118)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	111	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

NGEF_HUMAN
NC score	0.052048 (rank : 119)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	111	Target Neighborhood Hits	166	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG5_HUMAN
NC score	0.051662 (rank : 120)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	111	Target Neighborhood Hits	172	Shared Neighborhood Hits	17
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

WWP1_MOUSE
NC score	0.050949 (rank : 121)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	111	Target Neighborhood Hits	138	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP1_HUMAN
NC score	0.050586 (rank : 122)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	111	Target Neighborhood Hits	262	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

GNRP_HUMAN
NC score	0.050288 (rank : 123)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	111	Target Neighborhood Hits	239	Shared Neighborhood Hits	22
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

NGEF_MOUSE
NC score	0.050128 (rank : 124)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	111	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

MCF2_HUMAN
NC score	0.050082 (rank : 125)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	111	Target Neighborhood Hits	166	Shared Neighborhood Hits	16
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

OGT1_HUMAN
NC score	0.046099 (rank : 126)	θ value	0.0961366 (rank : 69)
Query Neighborhood Hits	111	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	O15294, Q7Z3K0, Q8WWM8, Q96CC1, Q9UG57	Gene names	OGT
Domain Architecture
Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.-) (O-GlcNAc transferase p110 subunit).

TR11B_MOUSE
NC score	0.030243 (rank : 127)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	111	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O08712, O70202	Gene names	Tnfrsf11b, Ocif, Opg
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 11B precursor (Osteoprotegerin) (Osteoclastogenesis inhibitory factor).

PLEK_HUMAN
NC score	0.028667 (rank : 128)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	9
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

SNX1_HUMAN
NC score	0.028557 (rank : 129)	θ value	1.06291 (rank : 78)
Query Neighborhood Hits	111	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q13596, O60750, O60751	Gene names	SNX1
Domain Architecture
Description	Sorting nexin-1.

CENA1_HUMAN
NC score	0.025002 (rank : 130)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	111	Target Neighborhood Hits	87	Shared Neighborhood Hits	13
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

PKHA1_HUMAN
NC score	0.024487 (rank : 131)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	111	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

POPD2_HUMAN
NC score	0.022614 (rank : 132)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	111	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBU9, Q86UE7	Gene names	POPDC2, POP2
Domain Architecture
Description	Popeye domain-containing protein 2 (Popeye protein 2).

PANK4_HUMAN
NC score	0.022441 (rank : 133)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	111	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVE7, Q53EU3, Q5TA84, Q7RTX3, Q9H3X5	Gene names	PANK4
Domain Architecture
Description	Pantothenate kinase 4 (EC 2.7.1.33) (Pantothenic acid kinase 4) (hPanK4).

CENA2_HUMAN
NC score	0.017934 (rank : 134)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	111	Target Neighborhood Hits	83	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CEND1_HUMAN
NC score	0.017891 (rank : 135)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	111	Target Neighborhood Hits	284	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

HCFC1_MOUSE
NC score	0.017376 (rank : 136)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	111	Target Neighborhood Hits	348	Shared Neighborhood Hits	6
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCFC1_HUMAN
NC score	0.017201 (rank : 137)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	111	Target Neighborhood Hits	331	Shared Neighborhood Hits	6
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

LPIN2_HUMAN
NC score	0.016133 (rank : 138)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

LPIN2_MOUSE
NC score	0.015679 (rank : 139)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	111	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

CEND1_MOUSE
NC score	0.015470 (rank : 140)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	111	Target Neighborhood Hits	260	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

ATR_HUMAN
NC score	0.015016 (rank : 141)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	111	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

VKGC_MOUSE
NC score	0.014577 (rank : 142)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	111	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QYC7, Q3UXN5, Q8CCB3	Gene names	Ggcx
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

KLH14_HUMAN
NC score	0.014514 (rank : 143)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	111	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P2G3	Gene names	KLHL14, KIAA1384
Domain Architecture	No domain graphic available
Description	Kelch-like protein 14.

VKGC_HUMAN
NC score	0.014476 (rank : 144)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	111	Target Neighborhood Hits	19	Shared Neighborhood Hits	4
SwissProt Accessions	P38435, Q14415, Q6GU45	Gene names	GGCX, GC
Domain Architecture
Description	Vitamin K-dependent gamma-carboxylase (EC 6.4.-.-) (Gamma-glutamyl carboxylase) (Vitamin K gamma glutamyl carboxylase).

E2AK4_MOUSE
NC score	0.012509 (rank : 145)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	111	Target Neighborhood Hits	984	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

HEY2_MOUSE
NC score	0.011995 (rank : 146)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	111	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

PKCB1_HUMAN
NC score	0.011837 (rank : 147)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	111	Target Neighborhood Hits	488	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

K0406_MOUSE
NC score	0.011444 (rank : 148)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	111	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

PK3CD_MOUSE
NC score	0.011297 (rank : 149)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	111	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

MARK2_MOUSE
NC score	0.010091 (rank : 150)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	111	Target Neighborhood Hits	1018	Shared Neighborhood Hits	9
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

DKC1_HUMAN
NC score	0.009793 (rank : 151)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	111	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O60832, O43845, Q96G67, Q9Y505	Gene names	DKC1, NOLA4
Domain Architecture
Description	H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (Nopp140- associated protein of 57 kDa) (Nucleolar protein NAP57) (CBF5 homolog).

KLHL3_HUMAN
NC score	0.008962 (rank : 152)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	111	Target Neighborhood Hits	187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UH77, Q9UH75, Q9UH76, Q9ULU0, Q9Y6V6	Gene names	KLHL3, KIAA1129
Domain Architecture
Description	Kelch-like protein 3.

GP112_HUMAN
NC score	0.008550 (rank : 153)	θ value	2.36792 (rank : 80)
Query Neighborhood Hits	111	Target Neighborhood Hits	441	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IZF6, Q86SM6	Gene names	GPR112
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 112.

MYO10_HUMAN
NC score	0.008245 (rank : 154)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	111	Target Neighborhood Hits	920	Shared Neighborhood Hits	10
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

R113A_HUMAN
NC score	0.008244 (rank : 155)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	111	Target Neighborhood Hits	177	Shared Neighborhood Hits	2
SwissProt Accessions	O15541	Gene names	RNF113A, RNF113, ZNF183
Domain Architecture
Description	RING finger protein 113A (Zinc finger protein 183).

MAML3_HUMAN
NC score	0.008070 (rank : 156)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	111	Target Neighborhood Hits	323	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

PRAX_HUMAN
NC score	0.007359 (rank : 157)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	111	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PDLI1_HUMAN
NC score	0.005910 (rank : 158)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	111	Target Neighborhood Hits	242	Shared Neighborhood Hits	2
SwissProt Accessions	O00151, Q5VZH5, Q9BPZ9	Gene names	PDLIM1, CLIM1, CLP36
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

CSMD2_HUMAN
NC score	0.005371 (rank : 159)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	111	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

MLL3_HUMAN
NC score	0.005340 (rank : 160)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	111	Target Neighborhood Hits	1644	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

CCNB3_HUMAN
NC score	0.003688 (rank : 161)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	111	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ATBF1_MOUSE
NC score	-0.001744 (rank : 162)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	111	Target Neighborhood Hits	1841	Shared Neighborhood Hits	7
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).