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Network neighborhood for query Sequence : ZFY21_HUMAN

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ZFY21_HUMAN
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ZFY21_HUMAN
θ value	2.0589e-137 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
θ value	2.61662e-116 (rank : 2)	NC score	0.996292 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FYV1_HUMAN
θ value	2.60593e-15 (rank : 3)	NC score	0.623906 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ZFY28_HUMAN
θ value	4.44505e-15 (rank : 4)	NC score	0.812010 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

FYV1_MOUSE
θ value	5.8054e-15 (rank : 5)	NC score	0.624763 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY16_HUMAN
θ value	2.43908e-13 (rank : 6)	NC score	0.718822 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	7.09661e-13 (rank : 7)	NC score	0.727552 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

MTMR3_HUMAN
θ value	1.2105e-12 (rank : 8)	NC score	0.458877 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

ZFYV9_HUMAN
θ value	6.00763e-12 (rank : 9)	NC score	0.730044 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

FGD6_HUMAN
θ value	4.30538e-10 (rank : 10)	NC score	0.556809 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

ANFY1_MOUSE
θ value	1.63604e-09 (rank : 11)	NC score	0.305079 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

HGS_MOUSE
θ value	1.63604e-09 (rank : 12)	NC score	0.586910 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	589	Shared Neighborhood Hits	55
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FGD6_MOUSE
θ value	2.79066e-09 (rank : 13)	NC score	0.543191 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

HGS_HUMAN
θ value	2.79066e-09 (rank : 14)	NC score	0.589199 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	517	Shared Neighborhood Hits	55
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

RUFY1_HUMAN
θ value	2.79066e-09 (rank : 15)	NC score	0.426914 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	848	Shared Neighborhood Hits	57
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_HUMAN
θ value	2.79066e-09 (rank : 16)	NC score	0.339201 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	1208	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

PKHF1_HUMAN
θ value	3.64472e-09 (rank : 17)	NC score	0.713952 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RUFY1_MOUSE
θ value	4.76016e-09 (rank : 18)	NC score	0.434128 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	765	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

ANFY1_HUMAN
θ value	6.21693e-09 (rank : 19)	NC score	0.302217 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

RUFY2_MOUSE
θ value	6.21693e-09 (rank : 20)	NC score	0.426975 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	820	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

FGD2_HUMAN
θ value	8.11959e-09 (rank : 21)	NC score	0.502744 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

WDFY3_HUMAN
θ value	1.06045e-08 (rank : 22)	NC score	0.431936 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	1.06045e-08 (rank : 23)	NC score	0.433688 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

FGD2_MOUSE
θ value	1.38499e-08 (rank : 24)	NC score	0.501507 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ZFYV1_HUMAN
θ value	2.36244e-08 (rank : 25)	NC score	0.646407 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

FYCO1_HUMAN
θ value	6.87365e-08 (rank : 26)	NC score	0.289272 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	1149	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

PKHF1_MOUSE
θ value	6.87365e-08 (rank : 27)	NC score	0.702290 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ZFYV1_MOUSE
θ value	1.17247e-07 (rank : 28)	NC score	0.640384 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	153	Shared Neighborhood Hits	58
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

EEA1_HUMAN
θ value	9.92553e-07 (rank : 29)	NC score	0.226256 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	1796	Shared Neighborhood Hits	58
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	9.92553e-07 (rank : 30)	NC score	0.245644 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	1637	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FGD4_MOUSE
θ value	9.92553e-07 (rank : 31)	NC score	0.467016 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

PKHF2_HUMAN
θ value	9.92553e-07 (rank : 32)	NC score	0.701666 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	9.92553e-07 (rank : 33)	NC score	0.703845 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	48
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

FGD4_HUMAN
θ value	1.69304e-06 (rank : 34)	NC score	0.469718 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

WDFY2_HUMAN
θ value	2.88788e-06 (rank : 35)	NC score	0.427929 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	2.88788e-06 (rank : 36)	NC score	0.431228 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FGD5_HUMAN
θ value	6.43352e-06 (rank : 37)	NC score	0.537228 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	6.43352e-06 (rank : 38)	NC score	0.546185 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

WDFY1_HUMAN
θ value	6.43352e-06 (rank : 39)	NC score	0.437266 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

FYCO1_MOUSE
θ value	8.40245e-06 (rank : 40)	NC score	0.267933 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	1059	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ZFY27_HUMAN
θ value	1.09739e-05 (rank : 41)	NC score	0.488649 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	1.87187e-05 (rank : 42)	NC score	0.485593 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

RBNS5_HUMAN
θ value	0.000158464 (rank : 43)	NC score	0.516507 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	242	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	0.000158464 (rank : 44)	NC score	0.511744 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FGD1_HUMAN
θ value	0.000602161 (rank : 45)	NC score	0.447561 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	367	Shared Neighborhood Hits	50
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	0.000602161 (rank : 46)	NC score	0.446752 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	387	Shared Neighborhood Hits	50
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD3_HUMAN
θ value	0.000786445 (rank : 47)	NC score	0.428783 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

RFFL_HUMAN
θ value	0.00869519 (rank : 48)	NC score	0.209127 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

ZFY19_MOUSE
θ value	0.0563607 (rank : 49)	NC score	0.477586 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RFFL_MOUSE
θ value	0.0736092 (rank : 50)	NC score	0.211759 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

ZFY19_HUMAN
θ value	0.0736092 (rank : 51)	NC score	0.480141 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FGD3_MOUSE
θ value	0.0961366 (rank : 52)	NC score	0.378584 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RNF34_MOUSE
θ value	0.163984 (rank : 53)	NC score	0.207021 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	160	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

TRAF2_MOUSE
θ value	0.279714 (rank : 54)	NC score	0.021462 (rank : 127)
Query Neighborhood Hits	72	Target Neighborhood Hits	394	Shared Neighborhood Hits	7
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

RNF34_HUMAN
θ value	0.365318 (rank : 55)	NC score	0.197053 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

ZFAN3_HUMAN
θ value	0.813845 (rank : 56)	NC score	0.059561 (rank : 104)
Query Neighborhood Hits	72	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8U3, Q5SZZ0, Q5SZZ1	Gene names	ZFAND3, TEX27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

ZFAN3_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.061347 (rank : 100)
Query Neighborhood Hits	72	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

ZN181_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.004796 (rank : 130)
Query Neighborhood Hits	72	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZN449_HUMAN
θ value	1.06291 (rank : 59)	NC score	0.003789 (rank : 132)
Query Neighborhood Hits	72	Target Neighborhood Hits	758	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P9G9, Q5JRZ8, Q6NZX2, Q8N3Q1, Q8TED7	Gene names	ZNF449, ZSCAN19
Domain Architecture	No domain graphic available
Description	Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19).

SPY1_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.021164 (rank : 128)
Query Neighborhood Hits	72	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

ZN11B_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.003644 (rank : 133)
Query Neighborhood Hits	72	Target Neighborhood Hits	802	Shared Neighborhood Hits	22
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

ZMYM3_HUMAN
θ value	5.27518 (rank : 62)	NC score	0.029823 (rank : 125)
Query Neighborhood Hits	72	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

ZMYM3_MOUSE
θ value	5.27518 (rank : 63)	NC score	0.030289 (rank : 124)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

ZN300_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.002499 (rank : 135)
Query Neighborhood Hits	72	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	Q96RE9	Gene names	ZNF300
Domain Architecture
Description	Zinc finger protein 300.

ZN331_HUMAN
θ value	5.27518 (rank : 65)	NC score	0.001495 (rank : 137)
Query Neighborhood Hits	72	Target Neighborhood Hits	742	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQX6, Q96GJ4	Gene names	ZNF331, RITA, ZNF463
Domain Architecture
Description	Zinc finger protein 331 (Zinc finger protein 463) (C2H2-like zinc finger protein rearranged in thyroid adenomas).

ZN709_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.003119 (rank : 134)
Query Neighborhood Hits	72	Target Neighborhood Hits	746	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N972	Gene names	ZNF709
Domain Architecture	No domain graphic available
Description	Zinc finger protein 709.

LRSM1_MOUSE
θ value	6.88961 (rank : 67)	NC score	0.026625 (rank : 126)
Query Neighborhood Hits	72	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

RNF17_MOUSE
θ value	6.88961 (rank : 68)	NC score	0.052177 (rank : 117)
Query Neighborhood Hits	72	Target Neighborhood Hits	147	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

ZNF14_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.004319 (rank : 131)
Query Neighborhood Hits	72	Target Neighborhood Hits	760	Shared Neighborhood Hits	22
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

ZN330_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.011472 (rank : 129)
Query Neighborhood Hits	72	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q922H9, Q8C389, Q8K2M4	Gene names	Znf330, Noa36, Zfp330
Domain Architecture	No domain graphic available
Description	Zinc finger protein 330 (Nucleolar cysteine-rich protein) (Nucleolar autoantigen 36).

ZN433_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.001863 (rank : 136)
Query Neighborhood Hits	72	Target Neighborhood Hits	782	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN485_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.000886 (rank : 138)
Query Neighborhood Hits	72	Target Neighborhood Hits	744	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NCK3, Q96CL0	Gene names	ZNF485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 485.

ABR_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.080329 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ALS2_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.057552 (rank : 107)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG1_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.080210 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.079375 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	266	Shared Neighborhood Hits	13
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.064318 (rank : 94)
Query Neighborhood Hits	72	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.089675 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.052402 (rank : 115)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.053633 (rank : 113)
Query Neighborhood Hits	72	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.082964 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.082199 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.111154 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG7_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.062444 (rank : 97)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	14
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.051356 (rank : 119)
Query Neighborhood Hits	72	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.054731 (rank : 111)
Query Neighborhood Hits	72	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.076408 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	235	Shared Neighborhood Hits	11
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.075192 (rank : 88)
Query Neighborhood Hits	72	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.105053 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.106619 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.062172 (rank : 98)
Query Neighborhood Hits	72	Target Neighborhood Hits	375	Shared Neighborhood Hits	13
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.061643 (rank : 99)
Query Neighborhood Hits	72	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.061030 (rank : 101)
Query Neighborhood Hits	72	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.098987 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	12
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.095743 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.088674 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCR_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.081932 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CARD9_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.050622 (rank : 122)
Query Neighborhood Hits	72	Target Neighborhood Hits	602	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CJ064_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.108228 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

ECT2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.124529 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.127656 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.135023 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	241	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.139638 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	240	Shared Neighborhood Hits	17
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.138388 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	209	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.083172 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	239	Shared Neighborhood Hits	14
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.082980 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.104195 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	350	Shared Neighborhood Hits	19
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.068946 (rank : 89)
Query Neighborhood Hits	72	Target Neighborhood Hits	1757	Shared Neighborhood Hits	21
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.068439 (rank : 90)
Query Neighborhood Hits	72	Target Neighborhood Hits	1669	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.067961 (rank : 91)
Query Neighborhood Hits	72	Target Neighborhood Hits	1173	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.067507 (rank : 92)
Query Neighborhood Hits	72	Target Neighborhood Hits	1371	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.082658 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LRBA_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.052286 (rank : 116)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

LYST_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.056135 (rank : 109)
Query Neighborhood Hits	72	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

LYST_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.059910 (rank : 102)
Query Neighborhood Hits	72	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

MCF2L_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.089985 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	255	Shared Neighborhood Hits	16
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.088596 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MTMR3_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.059372 (rank : 105)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	1
SwissProt Accessions	Q8K296	Gene names	Mtmr3
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48).

NBEAL_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.064652 (rank : 93)
Query Neighborhood Hits	72	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

NBEA_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.051202 (rank : 120)
Query Neighborhood Hits	72	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.051654 (rank : 118)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NGEF_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.098465 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.095902 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA6_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.059855 (rank : 103)
Query Neighborhood Hits	72	Target Neighborhood Hits	556	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.057133 (rank : 108)
Query Neighborhood Hits	72	Target Neighborhood Hits	591	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.107362 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	174	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.087738 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	200	Shared Neighborhood Hits	12
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PREX1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.141095 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RUFY3_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.146394 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	594	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.147825 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	579	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SWP70_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.058003 (rank : 106)
Query Neighborhood Hits	72	Target Neighborhood Hits	973	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.054050 (rank : 112)
Query Neighborhood Hits	72	Target Neighborhood Hits	1097	Shared Neighborhood Hits	25
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TIAM1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.063624 (rank : 95)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	11
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.062447 (rank : 96)
Query Neighborhood Hits	72	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.051131 (rank : 121)
Query Neighborhood Hits	72	Target Neighborhood Hits	456	Shared Neighborhood Hits	14
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.050415 (rank : 123)
Query Neighborhood Hits	72	Target Neighborhood Hits	398	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.054756 (rank : 110)
Query Neighborhood Hits	72	Target Neighborhood Hits	452	Shared Neighborhood Hits	11
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.052721 (rank : 114)
Query Neighborhood Hits	72	Target Neighborhood Hits	430	Shared Neighborhood Hits	10
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

ZFY21_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.0589e-137 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_MOUSE
NC score	0.996292 (rank : 2)	θ value	2.61662e-116 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.812010 (rank : 3)	θ value	4.44505e-15 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	152	Shared Neighborhood Hits	60
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
NC score	0.730044 (rank : 4)	θ value	6.00763e-12 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	134	Shared Neighborhood Hits	54
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
NC score	0.727552 (rank : 5)	θ value	7.09661e-13 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.718822 (rank : 6)	θ value	2.43908e-13 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

PKHF1_HUMAN
NC score	0.713952 (rank : 7)	θ value	3.64472e-09 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF2_MOUSE
NC score	0.703845 (rank : 8)	θ value	9.92553e-07 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	48
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF1_MOUSE
NC score	0.702290 (rank : 9)	θ value	6.87365e-08 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
NC score	0.701666 (rank : 10)	θ value	9.92553e-07 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ZFYV1_HUMAN
NC score	0.646407 (rank : 11)	θ value	2.36244e-08 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.640384 (rank : 12)	θ value	1.17247e-07 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	153	Shared Neighborhood Hits	58
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

FYV1_MOUSE
NC score	0.624763 (rank : 13)	θ value	5.8054e-15 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.623906 (rank : 14)	θ value	2.60593e-15 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

HGS_HUMAN
NC score	0.589199 (rank : 15)	θ value	2.79066e-09 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	517	Shared Neighborhood Hits	55
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.586910 (rank : 16)	θ value	1.63604e-09 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	589	Shared Neighborhood Hits	55
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FGD6_HUMAN
NC score	0.556809 (rank : 17)	θ value	4.30538e-10 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	237	Shared Neighborhood Hits	50
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_MOUSE
NC score	0.546185 (rank : 18)	θ value	6.43352e-06 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_MOUSE
NC score	0.543191 (rank : 19)	θ value	2.79066e-09 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
NC score	0.537228 (rank : 20)	θ value	6.43352e-06 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

RBNS5_HUMAN
NC score	0.516507 (rank : 21)	θ value	0.000158464 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	242	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
NC score	0.511744 (rank : 22)	θ value	0.000158464 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FGD2_HUMAN
NC score	0.502744 (rank : 23)	θ value	8.11959e-09 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
NC score	0.501507 (rank : 24)	θ value	1.38499e-08 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

ZFY27_HUMAN
NC score	0.488649 (rank : 25)	θ value	1.09739e-05 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
NC score	0.485593 (rank : 26)	θ value	1.87187e-05 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY19_HUMAN
NC score	0.480141 (rank : 27)	θ value	0.0736092 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
NC score	0.477586 (rank : 28)	θ value	0.0563607 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	143	Shared Neighborhood Hits	56
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FGD4_HUMAN
NC score	0.469718 (rank : 29)	θ value	1.69304e-06 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	219	Shared Neighborhood Hits	48
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.467016 (rank : 30)	θ value	9.92553e-07 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

MTMR3_HUMAN
NC score	0.458877 (rank : 31)	θ value	1.2105e-12 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

FGD1_HUMAN
NC score	0.447561 (rank : 32)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	367	Shared Neighborhood Hits	50
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.446752 (rank : 33)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	387	Shared Neighborhood Hits	50
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

WDFY1_HUMAN
NC score	0.437266 (rank : 34)	θ value	6.43352e-06 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RUFY1_MOUSE
NC score	0.434128 (rank : 35)	θ value	4.76016e-09 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	765	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

WDFY3_MOUSE
NC score	0.433688 (rank : 36)	θ value	1.06045e-08 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.431936 (rank : 37)	θ value	1.06045e-08 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY2_MOUSE
NC score	0.431228 (rank : 38)	θ value	2.88788e-06 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

FGD3_HUMAN
NC score	0.428783 (rank : 39)	θ value	0.000786445 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

WDFY2_HUMAN
NC score	0.427929 (rank : 40)	θ value	2.88788e-06 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_MOUSE
NC score	0.426975 (rank : 41)	θ value	6.21693e-09 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	820	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_HUMAN
NC score	0.426914 (rank : 42)	θ value	2.79066e-09 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	848	Shared Neighborhood Hits	57
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

FGD3_MOUSE
NC score	0.378584 (rank : 43)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RUFY2_HUMAN
NC score	0.339201 (rank : 44)	θ value	2.79066e-09 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	1208	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

ANFY1_MOUSE
NC score	0.305079 (rank : 45)	θ value	1.63604e-09 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	480	Shared Neighborhood Hits	54
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.302217 (rank : 46)	θ value	6.21693e-09 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	480	Shared Neighborhood Hits	52
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FYCO1_HUMAN
NC score	0.289272 (rank : 47)	θ value	6.87365e-08 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	1149	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYCO1_MOUSE
NC score	0.267933 (rank : 48)	θ value	8.40245e-06 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	1059	Shared Neighborhood Hits	52
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_MOUSE
NC score	0.245644 (rank : 49)	θ value	9.92553e-07 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	1637	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
NC score	0.226256 (rank : 50)	θ value	9.92553e-07 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	1796	Shared Neighborhood Hits	58
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

RFFL_MOUSE
NC score	0.211759 (rank : 51)	θ value	0.0736092 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	145	Shared Neighborhood Hits	36
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.209127 (rank : 52)	θ value	0.00869519 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RNF34_MOUSE
NC score	0.207021 (rank : 53)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	160	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.197053 (rank : 54)	θ value	0.365318 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RUFY3_MOUSE
NC score	0.147825 (rank : 55)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	72	Target Neighborhood Hits	579	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.146394 (rank : 56)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	72	Target Neighborhood Hits	594	Shared Neighborhood Hits	9
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PREX1_HUMAN
NC score	0.141095 (rank : 57)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP2_HUMAN
NC score	0.139638 (rank : 58)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	72	Target Neighborhood Hits	240	Shared Neighborhood Hits	17
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.138388 (rank : 59)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	72	Target Neighborhood Hits	209	Shared Neighborhood Hits	16
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.135023 (rank : 60)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	72	Target Neighborhood Hits	241	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ECT2_MOUSE
NC score	0.127656 (rank : 61)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.124529 (rank : 62)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	72	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG5_HUMAN
NC score	0.111154 (rank : 63)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

CJ064_HUMAN
NC score	0.108228 (rank : 64)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	72	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

PKHG1_HUMAN
NC score	0.107362 (rank : 65)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	72	Target Neighborhood Hits	174	Shared Neighborhood Hits	12
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_MOUSE
NC score	0.106619 (rank : 66)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.105053 (rank : 67)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	72	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HAPIP_HUMAN
NC score	0.104195 (rank : 68)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	72	Target Neighborhood Hits	350	Shared Neighborhood Hits	19
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHGF_HUMAN
NC score	0.098987 (rank : 69)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	72	Target Neighborhood Hits	214	Shared Neighborhood Hits	12
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_HUMAN
NC score	0.098465 (rank : 70)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
NC score	0.095902 (rank : 71)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	72	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_HUMAN
NC score	0.095743 (rank : 72)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	72	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
NC score	0.089985 (rank : 73)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	72	Target Neighborhood Hits	255	Shared Neighborhood Hits	16
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG2_MOUSE
NC score	0.089675 (rank : 74)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_MOUSE
NC score	0.088674 (rank : 75)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	72	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2_HUMAN
NC score	0.088596 (rank : 76)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PKHG4_HUMAN
NC score	0.087738 (rank : 77)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	72	Target Neighborhood Hits	200	Shared Neighborhood Hits	12
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

GNRP_HUMAN
NC score	0.083172 (rank : 78)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	72	Target Neighborhood Hits	239	Shared Neighborhood Hits	14
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
NC score	0.082980 (rank : 79)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	72	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHG4_HUMAN
NC score	0.082964 (rank : 80)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

LBC_HUMAN
NC score	0.082658 (rank : 81)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	72	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG4_MOUSE
NC score	0.082199 (rank : 82)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCR_HUMAN
NC score	0.081932 (rank : 83)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	72	Target Neighborhood Hits	204	Shared Neighborhood Hits	12
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.080329 (rank : 84)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
NC score	0.080210 (rank : 85)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	176	Shared Neighborhood Hits	12
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.079375 (rank : 86)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	266	Shared Neighborhood Hits	13
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG9_HUMAN
NC score	0.076408 (rank : 87)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	235	Shared Neighborhood Hits	11
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.075192 (rank : 88)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	72	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ITSN1_HUMAN
NC score	0.068946 (rank : 89)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	72	Target Neighborhood Hits	1757	Shared Neighborhood Hits	21
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.068439 (rank : 90)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	72	Target Neighborhood Hits	1669	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
NC score	0.067961 (rank : 91)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	72	Target Neighborhood Hits	1173	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.067507 (rank : 92)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	72	Target Neighborhood Hits	1371	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NBEAL_HUMAN
NC score	0.064652 (rank : 93)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	72	Target Neighborhood Hits	200	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

ARHG2_HUMAN
NC score	0.064318 (rank : 94)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

TIAM1_HUMAN
NC score	0.063624 (rank : 95)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	11
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
NC score	0.062447 (rank : 96)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	72	Target Neighborhood Hits	205	Shared Neighborhood Hits	12
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
NC score	0.062444 (rank : 97)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	14
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGB_HUMAN
NC score	0.062172 (rank : 98)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	72	Target Neighborhood Hits	375	Shared Neighborhood Hits	13
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.061643 (rank : 99)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	72	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ZFAN3_MOUSE
NC score	0.061347 (rank : 100)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

ARHGC_MOUSE
NC score	0.061030 (rank : 101)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	72	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

LYST_MOUSE
NC score	0.059910 (rank : 102)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	72	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

PKHA6_HUMAN
NC score	0.059855 (rank : 103)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	72	Target Neighborhood Hits	556	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

ZFAN3_HUMAN
NC score	0.059561 (rank : 104)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8U3, Q5SZZ0, Q5SZZ1	Gene names	ZFAND3, TEX27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

MTMR3_MOUSE
NC score	0.059372 (rank : 105)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	1
SwissProt Accessions	Q8K296	Gene names	Mtmr3
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48).

SWP70_HUMAN
NC score	0.058003 (rank : 106)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	72	Target Neighborhood Hits	973	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ALS2_MOUSE
NC score	0.057552 (rank : 107)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

PKHA6_MOUSE
NC score	0.057133 (rank : 108)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	72	Target Neighborhood Hits	591	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

LYST_HUMAN
NC score	0.056135 (rank : 109)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	72	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

VAV_HUMAN
NC score	0.054756 (rank : 110)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	72	Target Neighborhood Hits	452	Shared Neighborhood Hits	11
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG8_HUMAN
NC score	0.054731 (rank : 111)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SWP70_MOUSE
NC score	0.054050 (rank : 112)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	72	Target Neighborhood Hits	1097	Shared Neighborhood Hits	25
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ARHG3_MOUSE
NC score	0.053633 (rank : 113)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV_MOUSE
NC score	0.052721 (rank : 114)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	72	Target Neighborhood Hits	430	Shared Neighborhood Hits	10
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHG3_HUMAN
NC score	0.052402 (rank : 115)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

LRBA_HUMAN
NC score	0.052286 (rank : 116)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

RNF17_MOUSE
NC score	0.052177 (rank : 117)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	147	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MV7	Gene names	Rnf17
Domain Architecture
Description	RING finger protein 17.

NBEA_MOUSE
NC score	0.051654 (rank : 118)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

ARHG7_MOUSE
NC score	0.051356 (rank : 119)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

NBEA_HUMAN
NC score	0.051202 (rank : 120)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	72	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

VAV2_MOUSE
NC score	0.051131 (rank : 121)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	72	Target Neighborhood Hits	456	Shared Neighborhood Hits	14
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

CARD9_HUMAN
NC score	0.050622 (rank : 122)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	72	Target Neighborhood Hits	602	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

VAV3_HUMAN
NC score	0.050415 (rank : 123)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	72	Target Neighborhood Hits	398	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ZMYM3_MOUSE
NC score	0.030289 (rank : 124)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	177	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLM4, Q80U17	Gene names	Zmym3, Kiaa0385, Zfp261, Znf261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261) (DXHXS6673E protein).

ZMYM3_HUMAN
NC score	0.029823 (rank : 125)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	223	Shared Neighborhood Hits	10
SwissProt Accessions	Q14202, O15089	Gene names	ZMYM3, DXS6673E, KIAA0385, ZNF261
Domain Architecture	No domain graphic available
Description	Zinc finger MYM-type protein 3 (Zinc finger protein 261).

LRSM1_MOUSE
NC score	0.026625 (rank : 126)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	874	Shared Neighborhood Hits	13
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

TRAF2_MOUSE
NC score	0.021462 (rank : 127)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	394	Shared Neighborhood Hits	7
SwissProt Accessions	P39429, O54896	Gene names	Traf2
Domain Architecture
Description	TNF receptor-associated factor 2.

SPY1_HUMAN
NC score	0.021164 (rank : 128)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	64	Shared Neighborhood Hits	5
SwissProt Accessions	O43609, Q6PNE0	Gene names	SPRY1
Domain Architecture
Description	Sprouty homolog 1 (Spry-1).

ZN330_MOUSE
NC score	0.011472 (rank : 129)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	86	Shared Neighborhood Hits	4
SwissProt Accessions	Q922H9, Q8C389, Q8K2M4	Gene names	Znf330, Noa36, Zfp330
Domain Architecture	No domain graphic available
Description	Zinc finger protein 330 (Nucleolar cysteine-rich protein) (Nucleolar autoantigen 36).

ZN181_HUMAN
NC score	0.004796 (rank : 130)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZNF14_HUMAN
NC score	0.004319 (rank : 131)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	760	Shared Neighborhood Hits	22
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

ZN449_HUMAN
NC score	0.003789 (rank : 132)	θ value	1.06291 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	758	Shared Neighborhood Hits	15
SwissProt Accessions	Q6P9G9, Q5JRZ8, Q6NZX2, Q8N3Q1, Q8TED7	Gene names	ZNF449, ZSCAN19
Domain Architecture	No domain graphic available
Description	Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19).

ZN11B_HUMAN
NC score	0.003644 (rank : 133)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	802	Shared Neighborhood Hits	22
SwissProt Accessions	Q06732, Q86XY8, Q8NDW3	Gene names	ZNF11B
Domain Architecture	No domain graphic available
Description	Zinc finger protein 11B.

ZN709_HUMAN
NC score	0.003119 (rank : 134)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	746	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N972	Gene names	ZNF709
Domain Architecture	No domain graphic available
Description	Zinc finger protein 709.

ZN300_HUMAN
NC score	0.002499 (rank : 135)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	748	Shared Neighborhood Hits	16
SwissProt Accessions	Q96RE9	Gene names	ZNF300
Domain Architecture
Description	Zinc finger protein 300.

ZN433_HUMAN
NC score	0.001863 (rank : 136)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	782	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN331_HUMAN
NC score	0.001495 (rank : 137)	θ value	5.27518 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	742	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQX6, Q96GJ4	Gene names	ZNF331, RITA, ZNF463
Domain Architecture
Description	Zinc finger protein 331 (Zinc finger protein 463) (C2H2-like zinc finger protein rearranged in thyroid adenomas).

ZN485_HUMAN
NC score	0.000886 (rank : 138)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	744	Shared Neighborhood Hits	10
SwissProt Accessions	Q8NCK3, Q96CL0	Gene names	ZNF485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 485.