Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : ZFYV9_HUMAN

For an explanation of this page, click here

ZFYV9_HUMAN
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ZFY16_HUMAN
θ value	0 (rank : 1)	NC score	0.947491 (rank : 2)
Query Neighborhood Hits	134	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFYV9_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	134	Target Neighborhood Hits	134	Shared Neighborhood Hits	134
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_MOUSE
θ value	4.40161e-164 (rank : 3)	NC score	0.945409 (rank : 3)
Query Neighborhood Hits	134	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

FGD6_HUMAN
θ value	4.02038e-16 (rank : 4)	NC score	0.564634 (rank : 11)
Query Neighborhood Hits	134	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	8.95645e-16 (rank : 5)	NC score	0.553032 (rank : 14)
Query Neighborhood Hits	134	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZFY21_MOUSE
θ value	7.09661e-13 (rank : 6)	NC score	0.738308 (rank : 4)
Query Neighborhood Hits	134	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FGD2_MOUSE
θ value	1.58096e-12 (rank : 7)	NC score	0.508361 (rank : 21)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
θ value	2.0648e-12 (rank : 8)	NC score	0.508113 (rank : 22)
Query Neighborhood Hits	134	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
θ value	4.59992e-12 (rank : 9)	NC score	0.485848 (rank : 24)
Query Neighborhood Hits	134	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

PKHF2_HUMAN
θ value	4.59992e-12 (rank : 10)	NC score	0.685107 (rank : 8)
Query Neighborhood Hits	134	Target Neighborhood Hits	75	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	4.59992e-12 (rank : 11)	NC score	0.685663 (rank : 7)
Query Neighborhood Hits	134	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ZFY21_HUMAN
θ value	6.00763e-12 (rank : 12)	NC score	0.730044 (rank : 5)
Query Neighborhood Hits	134	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FGD1_MOUSE
θ value	7.84624e-12 (rank : 13)	NC score	0.480542 (rank : 28)
Query Neighborhood Hits	134	Target Neighborhood Hits	387	Shared Neighborhood Hits	53
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_MOUSE
θ value	1.33837e-11 (rank : 14)	NC score	0.482009 (rank : 27)
Query Neighborhood Hits	134	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_HUMAN
θ value	1.74796e-11 (rank : 15)	NC score	0.480035 (rank : 29)
Query Neighborhood Hits	134	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZFY28_HUMAN
θ value	3.89403e-11 (rank : 16)	NC score	0.694392 (rank : 6)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

FYV1_HUMAN
θ value	5.08577e-11 (rank : 17)	NC score	0.516728 (rank : 19)
Query Neighborhood Hits	134	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	5.08577e-11 (rank : 18)	NC score	0.515200 (rank : 20)
Query Neighborhood Hits	134	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FGD5_HUMAN
θ value	1.133e-10 (rank : 19)	NC score	0.553273 (rank : 13)
Query Neighborhood Hits	134	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

MTMR3_HUMAN
θ value	1.47974e-10 (rank : 20)	NC score	0.398026 (rank : 35)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY2_HUMAN
θ value	1.47974e-10 (rank : 21)	NC score	0.308666 (rank : 44)
Query Neighborhood Hits	134	Target Neighborhood Hits	1208	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

EEA1_HUMAN
θ value	2.52405e-10 (rank : 22)	NC score	0.216626 (rank : 50)
Query Neighborhood Hits	134	Target Neighborhood Hits	1796	Shared Neighborhood Hits	70
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
θ value	2.52405e-10 (rank : 23)	NC score	0.234057 (rank : 49)
Query Neighborhood Hits	134	Target Neighborhood Hits	1637	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY1_HUMAN
θ value	2.52405e-10 (rank : 24)	NC score	0.380995 (rank : 38)
Query Neighborhood Hits	134	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_MOUSE
θ value	2.52405e-10 (rank : 25)	NC score	0.386642 (rank : 37)
Query Neighborhood Hits	134	Target Neighborhood Hits	820	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

FGD5_MOUSE
θ value	3.29651e-10 (rank : 26)	NC score	0.561682 (rank : 12)
Query Neighborhood Hits	134	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PKHF1_MOUSE
θ value	3.29651e-10 (rank : 27)	NC score	0.670830 (rank : 10)
Query Neighborhood Hits	134	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
θ value	4.30538e-10 (rank : 28)	NC score	0.673172 (rank : 9)
Query Neighborhood Hits	134	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

RUFY1_MOUSE
θ value	4.30538e-10 (rank : 29)	NC score	0.388606 (rank : 36)
Query Neighborhood Hits	134	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

HGS_MOUSE
θ value	2.79066e-09 (rank : 30)	NC score	0.523924 (rank : 18)
Query Neighborhood Hits	134	Target Neighborhood Hits	589	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
θ value	8.11959e-09 (rank : 31)	NC score	0.524554 (rank : 17)
Query Neighborhood Hits	134	Target Neighborhood Hits	517	Shared Neighborhood Hits	61
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

WDFY3_MOUSE
θ value	1.38499e-08 (rank : 32)	NC score	0.378903 (rank : 39)
Query Neighborhood Hits	134	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

FYCO1_HUMAN
θ value	1.80886e-08 (rank : 33)	NC score	0.267908 (rank : 45)
Query Neighborhood Hits	134	Target Neighborhood Hits	1149	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

WDFY3_HUMAN
θ value	1.80886e-08 (rank : 34)	NC score	0.377244 (rank : 40)
Query Neighborhood Hits	134	Target Neighborhood Hits	348	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

ZFYV1_HUMAN
θ value	1.69304e-06 (rank : 35)	NC score	0.542479 (rank : 15)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFY19_HUMAN
θ value	2.21117e-06 (rank : 36)	NC score	0.488111 (rank : 23)
Query Neighborhood Hits	134	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ANFY1_MOUSE
θ value	3.77169e-06 (rank : 37)	NC score	0.252957 (rank : 46)
Query Neighborhood Hits	134	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

RBNS5_HUMAN
θ value	4.92598e-06 (rank : 38)	NC score	0.482745 (rank : 26)
Query Neighborhood Hits	134	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	4.92598e-06 (rank : 39)	NC score	0.478140 (rank : 30)
Query Neighborhood Hits	134	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ZFYV1_MOUSE
θ value	4.92598e-06 (rank : 40)	NC score	0.537297 (rank : 16)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

FYCO1_MOUSE
θ value	8.40245e-06 (rank : 41)	NC score	0.246498 (rank : 48)
Query Neighborhood Hits	134	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANFY1_HUMAN
θ value	1.09739e-05 (rank : 42)	NC score	0.248644 (rank : 47)
Query Neighborhood Hits	134	Target Neighborhood Hits	480	Shared Neighborhood Hits	55
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FGD3_HUMAN
θ value	1.09739e-05 (rank : 43)	NC score	0.439806 (rank : 31)
Query Neighborhood Hits	134	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ZFY19_MOUSE
θ value	1.87187e-05 (rank : 44)	NC score	0.483226 (rank : 25)
Query Neighborhood Hits	134	Target Neighborhood Hits	143	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZFY27_HUMAN
θ value	5.44631e-05 (rank : 45)	NC score	0.414509 (rank : 33)
Query Neighborhood Hits	134	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	7.1131e-05 (rank : 46)	NC score	0.418856 (rank : 32)
Query Neighborhood Hits	134	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

WDFY2_HUMAN
θ value	0.000121331 (rank : 47)	NC score	0.357331 (rank : 43)
Query Neighborhood Hits	134	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.000121331 (rank : 48)	NC score	0.360060 (rank : 42)
Query Neighborhood Hits	134	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY1_HUMAN
θ value	0.000270298 (rank : 49)	NC score	0.367154 (rank : 41)
Query Neighborhood Hits	134	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

FGD3_MOUSE
θ value	0.00035302 (rank : 50)	NC score	0.401254 (rank : 34)
Query Neighborhood Hits	134	Target Neighborhood Hits	257	Shared Neighborhood Hits	52
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

DSPP_HUMAN
θ value	0.00298849 (rank : 51)	NC score	0.088359 (rank : 85)
Query Neighborhood Hits	134	Target Neighborhood Hits	645	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

RFFL_HUMAN
θ value	0.0193708 (rank : 52)	NC score	0.172148 (rank : 52)
Query Neighborhood Hits	134	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	0.0193708 (rank : 53)	NC score	0.184984 (rank : 51)
Query Neighborhood Hits	134	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

CJ118_HUMAN
θ value	0.0431538 (rank : 54)	NC score	0.051043 (rank : 121)
Query Neighborhood Hits	134	Target Neighborhood Hits	937	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

CJ118_MOUSE
θ value	0.0563607 (rank : 55)	NC score	0.051927 (rank : 120)
Query Neighborhood Hits	134	Target Neighborhood Hits	1132	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

MYRIP_MOUSE
θ value	0.0563607 (rank : 56)	NC score	0.072026 (rank : 94)
Query Neighborhood Hits	134	Target Neighborhood Hits	207	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

RP1_HUMAN
θ value	0.0736092 (rank : 57)	NC score	0.043276 (rank : 124)
Query Neighborhood Hits	134	Target Neighborhood Hits	87	Shared Neighborhood Hits	9
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

ZCHC6_HUMAN
θ value	0.0961366 (rank : 58)	NC score	0.036971 (rank : 129)
Query Neighborhood Hits	134	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

PAF49_HUMAN
θ value	0.279714 (rank : 59)	NC score	0.041050 (rank : 125)
Query Neighborhood Hits	134	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

E2F4_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.026716 (rank : 139)
Query Neighborhood Hits	134	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q16254, Q12991, Q15328	Gene names	E2F4
Domain Architecture
Description	Transcription factor E2F4 (E2F-4).

KS6A5_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.000949 (rank : 188)
Query Neighborhood Hits	134	Target Neighborhood Hits	855	Shared Neighborhood Hits	5
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

BCAS1_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.040248 (rank : 126)
Query Neighborhood Hits	134	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

RANB9_HUMAN
θ value	0.47712 (rank : 63)	NC score	0.033141 (rank : 131)
Query Neighborhood Hits	134	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

RNF34_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.169860 (rank : 54)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

DSPP_MOUSE
θ value	0.62314 (rank : 65)	NC score	0.067899 (rank : 102)
Query Neighborhood Hits	134	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

SPRL1_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.028409 (rank : 135)
Query Neighborhood Hits	134	Target Neighborhood Hits	403	Shared Neighborhood Hits	16
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

ZHX2_MOUSE
θ value	0.62314 (rank : 67)	NC score	0.019776 (rank : 148)
Query Neighborhood Hits	134	Target Neighborhood Hits	435	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

AFF4_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.019473 (rank : 150)
Query Neighborhood Hits	134	Target Neighborhood Hits	611	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

KS6A5_MOUSE
θ value	0.813845 (rank : 69)	NC score	0.000820 (rank : 189)
Query Neighborhood Hits	134	Target Neighborhood Hits	854	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

RRMJ3_HUMAN
θ value	0.813845 (rank : 70)	NC score	0.035750 (rank : 130)
Query Neighborhood Hits	134	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

TRAIP_MOUSE
θ value	0.813845 (rank : 71)	NC score	0.053060 (rank : 117)
Query Neighborhood Hits	134	Target Neighborhood Hits	745	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

ANR21_HUMAN
θ value	1.06291 (rank : 72)	NC score	0.028431 (rank : 134)
Query Neighborhood Hits	134	Target Neighborhood Hits	864	Shared Neighborhood Hits	23
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

CYLC1_HUMAN
θ value	1.06291 (rank : 73)	NC score	0.025662 (rank : 140)
Query Neighborhood Hits	134	Target Neighborhood Hits	408	Shared Neighborhood Hits	13
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

MYST4_HUMAN
θ value	1.06291 (rank : 74)	NC score	0.025257 (rank : 142)
Query Neighborhood Hits	134	Target Neighborhood Hits	671	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

RNF34_MOUSE
θ value	1.06291 (rank : 75)	NC score	0.170749 (rank : 53)
Query Neighborhood Hits	134	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

SAMN1_MOUSE
θ value	1.06291 (rank : 76)	NC score	0.022419 (rank : 144)
Query Neighborhood Hits	134	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

DAB2_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.028930 (rank : 133)
Query Neighborhood Hits	134	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

K0423_HUMAN
θ value	1.81305 (rank : 78)	NC score	0.027013 (rank : 138)
Query Neighborhood Hits	134	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

MBD6_HUMAN
θ value	1.81305 (rank : 79)	NC score	0.025464 (rank : 141)
Query Neighborhood Hits	134	Target Neighborhood Hits	349	Shared Neighborhood Hits	9
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

SOX6_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.015945 (rank : 158)
Query Neighborhood Hits	134	Target Neighborhood Hits	341	Shared Neighborhood Hits	9
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

DMP1_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.031379 (rank : 132)
Query Neighborhood Hits	134	Target Neighborhood Hits	491	Shared Neighborhood Hits	16
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

MAP9_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.039639 (rank : 127)
Query Neighborhood Hits	134	Target Neighborhood Hits	518	Shared Neighborhood Hits	19
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

POT15_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.027987 (rank : 136)
Query Neighborhood Hits	134	Target Neighborhood Hits	893	Shared Neighborhood Hits	24
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

AIM1_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.027564 (rank : 137)
Query Neighborhood Hits	134	Target Neighborhood Hits	247	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

CA103_MOUSE
θ value	3.0926 (rank : 85)	NC score	0.022709 (rank : 143)
Query Neighborhood Hits	134	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

FLRT3_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.003017 (rank : 185)
Query Neighborhood Hits	134	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

HSF1_MOUSE
θ value	3.0926 (rank : 87)	NC score	0.018641 (rank : 152)
Query Neighborhood Hits	134	Target Neighborhood Hits	267	Shared Neighborhood Hits	10
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

NOL4_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.018673 (rank : 151)
Query Neighborhood Hits	134	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P60954	Gene names	Nol4
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4.

SET1A_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.018147 (rank : 154)
Query Neighborhood Hits	134	Target Neighborhood Hits	690	Shared Neighborhood Hits	22
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

UBP10_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.013059 (rank : 164)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	6
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

ZBT38_HUMAN
θ value	3.0926 (rank : 91)	NC score	-0.001820 (rank : 194)
Query Neighborhood Hits	134	Target Neighborhood Hits	885	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

NCOR2_MOUSE
θ value	4.03905 (rank : 92)	NC score	0.011455 (rank : 168)
Query Neighborhood Hits	134	Target Neighborhood Hits	790	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

S13A4_HUMAN
θ value	4.03905 (rank : 93)	NC score	0.011436 (rank : 169)
Query Neighborhood Hits	134	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKG4	Gene names	SLC13A4, SUT1
Domain Architecture
Description	Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1).

ZBT24_MOUSE
θ value	4.03905 (rank : 94)	NC score	-0.003897 (rank : 196)
Query Neighborhood Hits	134	Target Neighborhood Hits	894	Shared Neighborhood Hits	7
SwissProt Accessions	Q80X44, Q3UIB7, Q7TPC4, Q8CJC9	Gene names	Zbtb24, Bif1, Bsg1, Znf450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) (Bone morphogenetic protein-induced factor 1) (Brain-specific protein 1).

ADA29_HUMAN
θ value	5.27518 (rank : 95)	NC score	0.002647 (rank : 186)
Query Neighborhood Hits	134	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ATP4A_MOUSE
θ value	5.27518 (rank : 96)	NC score	0.003532 (rank : 184)
Query Neighborhood Hits	134	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q64436, Q9CV46	Gene names	Atp4a
Domain Architecture
Description	Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Proton pump) (Gastric H+/K+ ATPase subunit alpha).

BAT2_MOUSE
θ value	5.27518 (rank : 97)	NC score	0.016116 (rank : 157)
Query Neighborhood Hits	134	Target Neighborhood Hits	947	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

EVI2B_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.016198 (rank : 156)
Query Neighborhood Hits	134	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VD58, Q3U1A3	Gene names	Evi2b
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

HELC1_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.012024 (rank : 166)
Query Neighborhood Hits	134	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

MK07_MOUSE
θ value	5.27518 (rank : 100)	NC score	-0.001854 (rank : 195)
Query Neighborhood Hits	134	Target Neighborhood Hits	1054	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

PCDBG_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.000040 (rank : 192)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRJ7, Q8IYD5, Q96SE9, Q9HCF1	Gene names	PCDHB16, KIAA1621, PCDH3X
Domain Architecture
Description	Protocadherin beta 16 precursor (PCDH-beta16) (Protocadherin 3X).

TMF1_HUMAN
θ value	5.27518 (rank : 102)	NC score	0.037813 (rank : 128)
Query Neighborhood Hits	134	Target Neighborhood Hits	987	Shared Neighborhood Hits	22
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

BTBDC_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.016426 (rank : 155)
Query Neighborhood Hits	134	Target Neighborhood Hits	248	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CCD82_HUMAN
θ value	6.88961 (rank : 104)	NC score	0.020274 (rank : 145)
Query Neighborhood Hits	134	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

CCDC4_HUMAN
θ value	6.88961 (rank : 105)	NC score	0.018636 (rank : 153)
Query Neighborhood Hits	134	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CSMD3_HUMAN
θ value	6.88961 (rank : 106)	NC score	0.002289 (rank : 187)
Query Neighborhood Hits	134	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

DAB2_MOUSE
θ value	6.88961 (rank : 107)	NC score	0.019491 (rank : 149)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	6
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

ICAL_HUMAN
θ value	6.88961 (rank : 108)	NC score	0.011237 (rank : 170)
Query Neighborhood Hits	134	Target Neighborhood Hits	275	Shared Neighborhood Hits	6
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

JHD2C_HUMAN
θ value	6.88961 (rank : 109)	NC score	0.012567 (rank : 165)
Query Neighborhood Hits	134	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

MOCS3_HUMAN
θ value	6.88961 (rank : 110)	NC score	0.014898 (rank : 161)
Query Neighborhood Hits	134	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

RFX3_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.011210 (rank : 172)
Query Neighborhood Hits	134	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	P48380, Q5JTL7, Q5JTL8, Q6NW13, Q8WTU4, Q95HL5, Q95HL6	Gene names	RFX3
Domain Architecture
Description	Transcription factor RFX3.

RFX3_MOUSE
θ value	6.88961 (rank : 112)	NC score	0.011217 (rank : 171)
Query Neighborhood Hits	134	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	P48381, Q8BLW2, Q8C0R3, Q8VBY6	Gene names	Rfx3
Domain Architecture
Description	Transcription factor RFX3.

S28A2_MOUSE
θ value	6.88961 (rank : 113)	NC score	0.010669 (rank : 174)
Query Neighborhood Hits	134	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O88627	Gene names	Slc28a2, Cnt2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (Sodium/purine nucleoside cotransporter) (SPNT).

STAP2_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.012000 (rank : 167)
Query Neighborhood Hits	134	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

THIC_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.007200 (rank : 178)
Query Neighborhood Hits	134	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CAY6, Q3TJY7, Q62292, Q96EB7, Q99K88, Q9CYV2	Gene names	Acat2
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase).

UTY_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.009794 (rank : 176)
Query Neighborhood Hits	134	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P79457, O97979	Gene names	Uty
Domain Architecture
Description	Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein ON the Y chromosome) (Male- specific histocompatibility antigen H-YDB).

WDTC1_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.019923 (rank : 146)
Query Neighborhood Hits	134	Target Neighborhood Hits	299	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDTC1_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.019787 (rank : 147)
Query Neighborhood Hits	134	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

ARID2_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.013421 (rank : 163)
Query Neighborhood Hits	134	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

CCNB1_HUMAN
θ value	8.99809 (rank : 120)	NC score	0.005071 (rank : 182)
Query Neighborhood Hits	134	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	P14635	Gene names	CCNB1, CCNB
Domain Architecture
Description	G2/mitotic-specific cyclin-B1.

CLH2_HUMAN
θ value	8.99809 (rank : 121)	NC score	0.007175 (rank : 179)
Query Neighborhood Hits	134	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P53675, Q14017, Q15808, Q15809	Gene names	CLTCL1, CLH22, CLTCL, CLTD
Domain Architecture
Description	Clathrin heavy chain 2 (CLH-22).

EYA4_HUMAN
θ value	8.99809 (rank : 122)	NC score	0.004938 (rank : 183)
Query Neighborhood Hits	134	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O95677, O95464, O95679, Q8IW39, Q9NTR7	Gene names	EYA4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

FA53B_HUMAN
θ value	8.99809 (rank : 123)	NC score	0.010540 (rank : 175)
Query Neighborhood Hits	134	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

HTF4_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.005846 (rank : 181)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

IDUA_HUMAN
θ value	8.99809 (rank : 125)	NC score	0.015036 (rank : 159)
Query Neighborhood Hits	134	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P35475	Gene names	IDUA
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

IDUA_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.014956 (rank : 160)
Query Neighborhood Hits	134	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P48441	Gene names	Idua
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

IRF1_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.006363 (rank : 180)
Query Neighborhood Hits	134	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P15314	Gene names	Irf1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

NEDD1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.009089 (rank : 177)
Query Neighborhood Hits	134	Target Neighborhood Hits	294	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

PTN13_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.000060 (rank : 191)
Query Neighborhood Hits	134	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

RIMS2_MOUSE
θ value	8.99809 (rank : 130)	NC score	0.013641 (rank : 162)
Query Neighborhood Hits	134	Target Neighborhood Hits	376	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

RNF31_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.011030 (rank : 173)
Query Neighborhood Hits	134	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

TITIN_HUMAN
θ value	8.99809 (rank : 132)	NC score	-0.001074 (rank : 193)
Query Neighborhood Hits	134	Target Neighborhood Hits	2923	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRI10_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.000731 (rank : 190)
Query Neighborhood Hits	134	Target Neighborhood Hits	315	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

ZNF18_MOUSE
θ value	8.99809 (rank : 134)	NC score	-0.004238 (rank : 197)
Query Neighborhood Hits	134	Target Neighborhood Hits	743	Shared Neighborhood Hits	4
SwissProt Accessions	Q810A1, Q9D972	Gene names	Znf18, Zfp535
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein 535).

ABR_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.088868 (rank : 83)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ALS2_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.058957 (rank : 108)
Query Neighborhood Hits	134	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.088610 (rank : 84)
Query Neighborhood Hits	134	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.087898 (rank : 86)
Query Neighborhood Hits	134	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.073184 (rank : 90)
Query Neighborhood Hits	134	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.100305 (rank : 72)
Query Neighborhood Hits	134	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.057863 (rank : 110)
Query Neighborhood Hits	134	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.059371 (rank : 106)
Query Neighborhood Hits	134	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.092416 (rank : 78)
Query Neighborhood Hits	134	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.091699 (rank : 81)
Query Neighborhood Hits	134	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.123508 (rank : 61)
Query Neighborhood Hits	134	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG7_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.069798 (rank : 98)
Query Neighborhood Hits	134	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.058494 (rank : 109)
Query Neighborhood Hits	134	Target Neighborhood Hits	396	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.057837 (rank : 111)
Query Neighborhood Hits	134	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.085659 (rank : 87)
Query Neighborhood Hits	134	Target Neighborhood Hits	235	Shared Neighborhood Hits	12
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.084417 (rank : 88)
Query Neighborhood Hits	134	Target Neighborhood Hits	234	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.116253 (rank : 66)
Query Neighborhood Hits	134	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.116831 (rank : 65)
Query Neighborhood Hits	134	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.070412 (rank : 97)
Query Neighborhood Hits	134	Target Neighborhood Hits	375	Shared Neighborhood Hits	14
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.069573 (rank : 99)
Query Neighborhood Hits	134	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.068839 (rank : 101)
Query Neighborhood Hits	134	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.110102 (rank : 69)
Query Neighborhood Hits	134	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.106960 (rank : 71)
Query Neighborhood Hits	134	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.099051 (rank : 73)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCR_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.090603 (rank : 82)
Query Neighborhood Hits	134	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CJ064_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.080233 (rank : 89)
Query Neighborhood Hits	134	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

ECT2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.138210 (rank : 60)
Query Neighborhood Hits	134	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.141727 (rank : 59)
Query Neighborhood Hits	134	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.147561 (rank : 58)
Query Neighborhood Hits	134	Target Neighborhood Hits	241	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.152465 (rank : 55)
Query Neighborhood Hits	134	Target Neighborhood Hits	240	Shared Neighborhood Hits	21
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.151102 (rank : 56)
Query Neighborhood Hits	134	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.091863 (rank : 80)
Query Neighborhood Hits	134	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.092161 (rank : 79)
Query Neighborhood Hits	134	Target Neighborhood Hits	191	Shared Neighborhood Hits	14
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.112082 (rank : 67)
Query Neighborhood Hits	134	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.072704 (rank : 92)
Query Neighborhood Hits	134	Target Neighborhood Hits	1757	Shared Neighborhood Hits	35
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.071598 (rank : 95)
Query Neighborhood Hits	134	Target Neighborhood Hits	1669	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.072517 (rank : 93)
Query Neighborhood Hits	134	Target Neighborhood Hits	1173	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.072931 (rank : 91)
Query Neighborhood Hits	134	Target Neighborhood Hits	1371	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.093197 (rank : 77)
Query Neighborhood Hits	134	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2L_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.098156 (rank : 74)
Query Neighborhood Hits	134	Target Neighborhood Hits	255	Shared Neighborhood Hits	17
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.096812 (rank : 75)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NBEAL_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.051030 (rank : 122)
Query Neighborhood Hits	134	Target Neighborhood Hits	200	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

NGEF_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.110213 (rank : 68)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.108068 (rank : 70)
Query Neighborhood Hits	134	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA6_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.065711 (rank : 103)
Query Neighborhood Hits	134	Target Neighborhood Hits	556	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.063182 (rank : 104)
Query Neighborhood Hits	134	Target Neighborhood Hits	591	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.121154 (rank : 64)
Query Neighborhood Hits	134	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.095072 (rank : 76)
Query Neighborhood Hits	134	Target Neighborhood Hits	200	Shared Neighborhood Hits	12
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PREX1_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.148164 (rank : 57)
Query Neighborhood Hits	134	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RGNEF_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.050088 (rank : 123)
Query Neighborhood Hits	134	Target Neighborhood Hits	641	Shared Neighborhood Hits	18
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RUFY3_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.122507 (rank : 63)
Query Neighborhood Hits	134	Target Neighborhood Hits	594	Shared Neighborhood Hits	13
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.123456 (rank : 62)
Query Neighborhood Hits	134	Target Neighborhood Hits	579	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SOS2_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.052636 (rank : 118)
Query Neighborhood Hits	134	Target Neighborhood Hits	193	Shared Neighborhood Hits	9
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SWP70_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.057312 (rank : 112)
Query Neighborhood Hits	134	Target Neighborhood Hits	973	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.054337 (rank : 116)
Query Neighborhood Hits	134	Target Neighborhood Hits	1097	Shared Neighborhood Hits	31
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TIAM1_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.071264 (rank : 96)
Query Neighborhood Hits	134	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.069312 (rank : 100)
Query Neighborhood Hits	134	Target Neighborhood Hits	205	Shared Neighborhood Hits	13
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.052069 (rank : 119)
Query Neighborhood Hits	134	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.056409 (rank : 113)
Query Neighborhood Hits	134	Target Neighborhood Hits	456	Shared Neighborhood Hits	14
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.056399 (rank : 114)
Query Neighborhood Hits	134	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.055649 (rank : 115)
Query Neighborhood Hits	134	Target Neighborhood Hits	404	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.061431 (rank : 105)
Query Neighborhood Hits	134	Target Neighborhood Hits	452	Shared Neighborhood Hits	13
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.058961 (rank : 107)
Query Neighborhood Hits	134	Target Neighborhood Hits	430	Shared Neighborhood Hits	11
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

ZFYV9_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	134	Target Neighborhood Hits	134	Shared Neighborhood Hits	134
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY16_HUMAN
NC score	0.947491 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	134	Target Neighborhood Hits	125	Shared Neighborhood Hits	59
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
NC score	0.945409 (rank : 3)	θ value	4.40161e-164 (rank : 3)
Query Neighborhood Hits	134	Target Neighborhood Hits	108	Shared Neighborhood Hits	55
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_MOUSE
NC score	0.738308 (rank : 4)	θ value	7.09661e-13 (rank : 6)
Query Neighborhood Hits	134	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.730044 (rank : 5)	θ value	6.00763e-12 (rank : 12)
Query Neighborhood Hits	134	Target Neighborhood Hits	72	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.694392 (rank : 6)	θ value	3.89403e-11 (rank : 16)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PKHF2_MOUSE
NC score	0.685663 (rank : 7)	θ value	4.59992e-12 (rank : 11)
Query Neighborhood Hits	134	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.685107 (rank : 8)	θ value	4.59992e-12 (rank : 10)
Query Neighborhood Hits	134	Target Neighborhood Hits	75	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF1_HUMAN
NC score	0.673172 (rank : 9)	θ value	4.30538e-10 (rank : 28)
Query Neighborhood Hits	134	Target Neighborhood Hits	76	Shared Neighborhood Hits	51
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.670830 (rank : 10)	θ value	3.29651e-10 (rank : 27)
Query Neighborhood Hits	134	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD6_HUMAN
NC score	0.564634 (rank : 11)	θ value	4.02038e-16 (rank : 4)
Query Neighborhood Hits	134	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_MOUSE
NC score	0.561682 (rank : 12)	θ value	3.29651e-10 (rank : 26)
Query Neighborhood Hits	134	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD5_HUMAN
NC score	0.553273 (rank : 13)	θ value	1.133e-10 (rank : 19)
Query Neighborhood Hits	134	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD6_MOUSE
NC score	0.553032 (rank : 14)	θ value	8.95645e-16 (rank : 5)
Query Neighborhood Hits	134	Target Neighborhood Hits	282	Shared Neighborhood Hits	51
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZFYV1_HUMAN
NC score	0.542479 (rank : 15)	θ value	1.69304e-06 (rank : 35)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.537297 (rank : 16)	θ value	4.92598e-06 (rank : 40)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

HGS_HUMAN
NC score	0.524554 (rank : 17)	θ value	8.11959e-09 (rank : 31)
Query Neighborhood Hits	134	Target Neighborhood Hits	517	Shared Neighborhood Hits	61
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
NC score	0.523924 (rank : 18)	θ value	2.79066e-09 (rank : 30)
Query Neighborhood Hits	134	Target Neighborhood Hits	589	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FYV1_HUMAN
NC score	0.516728 (rank : 19)	θ value	5.08577e-11 (rank : 17)
Query Neighborhood Hits	134	Target Neighborhood Hits	217	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
NC score	0.515200 (rank : 20)	θ value	5.08577e-11 (rank : 18)
Query Neighborhood Hits	134	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FGD2_MOUSE
NC score	0.508361 (rank : 21)	θ value	1.58096e-12 (rank : 7)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.508113 (rank : 22)	θ value	2.0648e-12 (rank : 8)
Query Neighborhood Hits	134	Target Neighborhood Hits	151	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ZFY19_HUMAN
NC score	0.488111 (rank : 23)	θ value	2.21117e-06 (rank : 36)
Query Neighborhood Hits	134	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FGD4_HUMAN
NC score	0.485848 (rank : 24)	θ value	4.59992e-12 (rank : 9)
Query Neighborhood Hits	134	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

ZFY19_MOUSE
NC score	0.483226 (rank : 25)	θ value	1.87187e-05 (rank : 44)
Query Neighborhood Hits	134	Target Neighborhood Hits	143	Shared Neighborhood Hits	52
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RBNS5_HUMAN
NC score	0.482745 (rank : 26)	θ value	4.92598e-06 (rank : 38)
Query Neighborhood Hits	134	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

FGD4_MOUSE
NC score	0.482009 (rank : 27)	θ value	1.33837e-11 (rank : 14)
Query Neighborhood Hits	134	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_MOUSE
NC score	0.480542 (rank : 28)	θ value	7.84624e-12 (rank : 13)
Query Neighborhood Hits	134	Target Neighborhood Hits	387	Shared Neighborhood Hits	53
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.480035 (rank : 29)	θ value	1.74796e-11 (rank : 15)
Query Neighborhood Hits	134	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

RBNS5_MOUSE
NC score	0.478140 (rank : 30)	θ value	4.92598e-06 (rank : 39)
Query Neighborhood Hits	134	Target Neighborhood Hits	266	Shared Neighborhood Hits	49
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FGD3_HUMAN
NC score	0.439806 (rank : 31)	θ value	1.09739e-05 (rank : 43)
Query Neighborhood Hits	134	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ZFY27_MOUSE
NC score	0.418856 (rank : 32)	θ value	7.1131e-05 (rank : 46)
Query Neighborhood Hits	134	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.414509 (rank : 33)	θ value	5.44631e-05 (rank : 45)
Query Neighborhood Hits	134	Target Neighborhood Hits	64	Shared Neighborhood Hits	45
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FGD3_MOUSE
NC score	0.401254 (rank : 34)	θ value	0.00035302 (rank : 50)
Query Neighborhood Hits	134	Target Neighborhood Hits	257	Shared Neighborhood Hits	52
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

MTMR3_HUMAN
NC score	0.398026 (rank : 35)	θ value	1.47974e-10 (rank : 20)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_MOUSE
NC score	0.388606 (rank : 36)	θ value	4.30538e-10 (rank : 29)
Query Neighborhood Hits	134	Target Neighborhood Hits	765	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_MOUSE
NC score	0.386642 (rank : 37)	θ value	2.52405e-10 (rank : 25)
Query Neighborhood Hits	134	Target Neighborhood Hits	820	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_HUMAN
NC score	0.380995 (rank : 38)	θ value	2.52405e-10 (rank : 24)
Query Neighborhood Hits	134	Target Neighborhood Hits	848	Shared Neighborhood Hits	60
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY3_MOUSE
NC score	0.378903 (rank : 39)	θ value	1.38499e-08 (rank : 32)
Query Neighborhood Hits	134	Target Neighborhood Hits	332	Shared Neighborhood Hits	58
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.377244 (rank : 40)	θ value	1.80886e-08 (rank : 34)
Query Neighborhood Hits	134	Target Neighborhood Hits	348	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY1_HUMAN
NC score	0.367154 (rank : 41)	θ value	0.000270298 (rank : 49)
Query Neighborhood Hits	134	Target Neighborhood Hits	305	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
NC score	0.360060 (rank : 42)	θ value	0.000121331 (rank : 48)
Query Neighborhood Hits	134	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.357331 (rank : 43)	θ value	0.000121331 (rank : 47)
Query Neighborhood Hits	134	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.308666 (rank : 44)	θ value	1.47974e-10 (rank : 21)
Query Neighborhood Hits	134	Target Neighborhood Hits	1208	Shared Neighborhood Hits	66
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

FYCO1_HUMAN
NC score	0.267908 (rank : 45)	θ value	1.80886e-08 (rank : 33)
Query Neighborhood Hits	134	Target Neighborhood Hits	1149	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ANFY1_MOUSE
NC score	0.252957 (rank : 46)	θ value	3.77169e-06 (rank : 37)
Query Neighborhood Hits	134	Target Neighborhood Hits	480	Shared Neighborhood Hits	57
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.248644 (rank : 47)	θ value	1.09739e-05 (rank : 42)
Query Neighborhood Hits	134	Target Neighborhood Hits	480	Shared Neighborhood Hits	55
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FYCO1_MOUSE
NC score	0.246498 (rank : 48)	θ value	8.40245e-06 (rank : 41)
Query Neighborhood Hits	134	Target Neighborhood Hits	1059	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_MOUSE
NC score	0.234057 (rank : 49)	θ value	2.52405e-10 (rank : 23)
Query Neighborhood Hits	134	Target Neighborhood Hits	1637	Shared Neighborhood Hits	66
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
NC score	0.216626 (rank : 50)	θ value	2.52405e-10 (rank : 22)
Query Neighborhood Hits	134	Target Neighborhood Hits	1796	Shared Neighborhood Hits	70
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

RFFL_MOUSE
NC score	0.184984 (rank : 51)	θ value	0.0193708 (rank : 53)
Query Neighborhood Hits	134	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.172148 (rank : 52)	θ value	0.0193708 (rank : 52)
Query Neighborhood Hits	134	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RNF34_MOUSE
NC score	0.170749 (rank : 53)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	134	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.169860 (rank : 54)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

FARP2_HUMAN
NC score	0.152465 (rank : 55)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	134	Target Neighborhood Hits	240	Shared Neighborhood Hits	21
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.151102 (rank : 56)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	134	Target Neighborhood Hits	209	Shared Neighborhood Hits	18
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PREX1_HUMAN
NC score	0.148164 (rank : 57)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	134	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP1_HUMAN
NC score	0.147561 (rank : 58)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	134	Target Neighborhood Hits	241	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ECT2_MOUSE
NC score	0.141727 (rank : 59)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	134	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.138210 (rank : 60)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	134	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ARHG5_HUMAN
NC score	0.123508 (rank : 61)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	134	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RUFY3_MOUSE
NC score	0.123456 (rank : 62)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	134	Target Neighborhood Hits	579	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.122507 (rank : 63)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	134	Target Neighborhood Hits	594	Shared Neighborhood Hits	13
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PKHG1_HUMAN
NC score	0.121154 (rank : 64)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	134	Target Neighborhood Hits	174	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_MOUSE
NC score	0.116831 (rank : 65)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	134	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.116253 (rank : 66)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	134	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HAPIP_HUMAN
NC score	0.112082 (rank : 67)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	134	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NGEF_HUMAN
NC score	0.110213 (rank : 68)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.110102 (rank : 69)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	134	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_MOUSE
NC score	0.108068 (rank : 70)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	134	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_HUMAN
NC score	0.106960 (rank : 71)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	134	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHG2_MOUSE
NC score	0.100305 (rank : 72)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	134	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_MOUSE
NC score	0.099051 (rank : 73)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
NC score	0.098156 (rank : 74)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	134	Target Neighborhood Hits	255	Shared Neighborhood Hits	17
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
NC score	0.096812 (rank : 75)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PKHG4_HUMAN
NC score	0.095072 (rank : 76)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	134	Target Neighborhood Hits	200	Shared Neighborhood Hits	12
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

LBC_HUMAN
NC score	0.093197 (rank : 77)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	134	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG4_HUMAN
NC score	0.092416 (rank : 78)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	134	Target Neighborhood Hits	242	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GNRP_MOUSE
NC score	0.092161 (rank : 79)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	134	Target Neighborhood Hits	191	Shared Neighborhood Hits	14
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
NC score	0.091863 (rank : 80)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	134	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG4_MOUSE
NC score	0.091699 (rank : 81)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	134	Target Neighborhood Hits	185	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCR_HUMAN
NC score	0.090603 (rank : 82)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	134	Target Neighborhood Hits	204	Shared Neighborhood Hits	13
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ABR_HUMAN
NC score	0.088868 (rank : 83)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	134	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
NC score	0.088610 (rank : 84)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	134	Target Neighborhood Hits	176	Shared Neighborhood Hits	14
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

DSPP_HUMAN
NC score	0.088359 (rank : 85)	θ value	0.00298849 (rank : 51)
Query Neighborhood Hits	134	Target Neighborhood Hits	645	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

ARHG1_MOUSE
NC score	0.087898 (rank : 86)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	134	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG9_HUMAN
NC score	0.085659 (rank : 87)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	134	Target Neighborhood Hits	235	Shared Neighborhood Hits	12
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.084417 (rank : 88)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	134	Target Neighborhood Hits	234	Shared Neighborhood Hits	12
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

CJ064_HUMAN
NC score	0.080233 (rank : 89)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	134	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

ARHG2_HUMAN
NC score	0.073184 (rank : 90)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	134	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ITSN2_MOUSE
NC score	0.072931 (rank : 91)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	134	Target Neighborhood Hits	1371	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.072704 (rank : 92)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	134	Target Neighborhood Hits	1757	Shared Neighborhood Hits	35
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
NC score	0.072517 (rank : 93)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	134	Target Neighborhood Hits	1173	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

MYRIP_MOUSE
NC score	0.072026 (rank : 94)	θ value	0.0563607 (rank : 56)
Query Neighborhood Hits	134	Target Neighborhood Hits	207	Shared Neighborhood Hits	21
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

ITSN1_MOUSE
NC score	0.071598 (rank : 95)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	134	Target Neighborhood Hits	1669	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TIAM1_HUMAN
NC score	0.071264 (rank : 96)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	134	Target Neighborhood Hits	225	Shared Neighborhood Hits	12
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGB_HUMAN
NC score	0.070412 (rank : 97)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	134	Target Neighborhood Hits	375	Shared Neighborhood Hits	14
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG7_HUMAN
NC score	0.069798 (rank : 98)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	134	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGC_HUMAN
NC score	0.069573 (rank : 99)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	134	Target Neighborhood Hits	351	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TIAM1_MOUSE
NC score	0.069312 (rank : 100)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	134	Target Neighborhood Hits	205	Shared Neighborhood Hits	13
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGC_MOUSE
NC score	0.068839 (rank : 101)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	134	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

DSPP_MOUSE
NC score	0.067899 (rank : 102)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	134	Target Neighborhood Hits	491	Shared Neighborhood Hits	15
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

PKHA6_HUMAN
NC score	0.065711 (rank : 103)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	134	Target Neighborhood Hits	556	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.063182 (rank : 104)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	134	Target Neighborhood Hits	591	Shared Neighborhood Hits	20
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

VAV_HUMAN
NC score	0.061431 (rank : 105)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	134	Target Neighborhood Hits	452	Shared Neighborhood Hits	13
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG3_MOUSE
NC score	0.059371 (rank : 106)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	134	Target Neighborhood Hits	85	Shared Neighborhood Hits	9
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

VAV_MOUSE
NC score	0.058961 (rank : 107)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	134	Target Neighborhood Hits	430	Shared Neighborhood Hits	11
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ALS2_MOUSE
NC score	0.058957 (rank : 108)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	134	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG7_MOUSE
NC score	0.058494 (rank : 109)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	134	Target Neighborhood Hits	396	Shared Neighborhood Hits	15
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG3_HUMAN
NC score	0.057863 (rank : 110)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	134	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_HUMAN
NC score	0.057837 (rank : 111)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	134	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SWP70_HUMAN
NC score	0.057312 (rank : 112)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	134	Target Neighborhood Hits	973	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

VAV2_MOUSE
NC score	0.056409 (rank : 113)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	134	Target Neighborhood Hits	456	Shared Neighborhood Hits	14
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
NC score	0.056399 (rank : 114)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	134	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.055649 (rank : 115)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	134	Target Neighborhood Hits	404	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SWP70_MOUSE
NC score	0.054337 (rank : 116)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	134	Target Neighborhood Hits	1097	Shared Neighborhood Hits	31
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TRAIP_MOUSE
NC score	0.053060 (rank : 117)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	134	Target Neighborhood Hits	745	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

SOS2_HUMAN
NC score	0.052636 (rank : 118)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	134	Target Neighborhood Hits	193	Shared Neighborhood Hits	9
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

VAV2_HUMAN
NC score	0.052069 (rank : 119)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	134	Target Neighborhood Hits	453	Shared Neighborhood Hits	13
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CJ118_MOUSE
NC score	0.051927 (rank : 120)	θ value	0.0563607 (rank : 55)
Query Neighborhood Hits	134	Target Neighborhood Hits	1132	Shared Neighborhood Hits	23
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CJ118_HUMAN
NC score	0.051043 (rank : 121)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	134	Target Neighborhood Hits	937	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

NBEAL_HUMAN
NC score	0.051030 (rank : 122)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	134	Target Neighborhood Hits	200	Shared Neighborhood Hits	8
SwissProt Accessions	Q6ZS30, Q6Y876, Q6ZQY5, Q96Q30	Gene names	NBEAL1, ALS2CR17
Domain Architecture	No domain graphic available
Description	Neurobeachin-like 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein).

RGNEF_MOUSE
NC score	0.050088 (rank : 123)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	134	Target Neighborhood Hits	641	Shared Neighborhood Hits	18
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RP1_HUMAN
NC score	0.043276 (rank : 124)	θ value	0.0736092 (rank : 57)
Query Neighborhood Hits	134	Target Neighborhood Hits	87	Shared Neighborhood Hits	9
SwissProt Accessions	P56715	Gene names	RP1, ORP1
Domain Architecture
Description	Oxygen-regulated protein 1 (Retinitis pigmentosa RP1 protein) (Retinitis pigmentosa 1 protein).

PAF49_HUMAN
NC score	0.041050 (rank : 125)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	134	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	O15446, Q32N11, Q7Z5U2, Q9UPF6	Gene names	CD3EAP, ASE1, CAST, PAF49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein) (CAST).

BCAS1_HUMAN
NC score	0.040248 (rank : 126)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	134	Target Neighborhood Hits	133	Shared Neighborhood Hits	9
SwissProt Accessions	O75363, Q68CZ3	Gene names	BCAS1, AIBC1, NABC1
Domain Architecture	No domain graphic available
Description	Breast carcinoma amplified sequence 1 (Novel amplified in breast cancer 1) (Amplified and overexpressed in breast cancer).

MAP9_HUMAN
NC score	0.039639 (rank : 127)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	134	Target Neighborhood Hits	518	Shared Neighborhood Hits	19
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

TMF1_HUMAN
NC score	0.037813 (rank : 128)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	134	Target Neighborhood Hits	987	Shared Neighborhood Hits	22
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

ZCHC6_HUMAN
NC score	0.036971 (rank : 129)	θ value	0.0961366 (rank : 58)
Query Neighborhood Hits	134	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

RRMJ3_HUMAN
NC score	0.035750 (rank : 130)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	134	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IY81, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6	Gene names	FTSJ3
Domain Architecture	No domain graphic available
Description	Putative rRNA methyltransferase 3 (EC 2.1.1.-) (rRNA (uridine-2'-O-)- methyltransferase 3).

RANB9_HUMAN
NC score	0.033141 (rank : 131)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	134	Target Neighborhood Hits	179	Shared Neighborhood Hits	8
SwissProt Accessions	Q96S59, O94764, Q6P3T7, Q7LBR2, Q7Z7F9	Gene names	RANBP9, RANBPM
Domain Architecture	No domain graphic available
Description	Ran-binding protein 9 (RanBP9) (RanBP7) (Ran-binding protein M) (RanBPM) (BPM90) (BPM-L).

DMP1_HUMAN
NC score	0.031379 (rank : 132)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	134	Target Neighborhood Hits	491	Shared Neighborhood Hits	16
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

DAB2_HUMAN
NC score	0.028930 (rank : 133)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	134	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

ANR21_HUMAN
NC score	0.028431 (rank : 134)	θ value	1.06291 (rank : 72)
Query Neighborhood Hits	134	Target Neighborhood Hits	864	Shared Neighborhood Hits	23
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

SPRL1_MOUSE
NC score	0.028409 (rank : 135)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	134	Target Neighborhood Hits	403	Shared Neighborhood Hits	16
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

POT15_HUMAN
NC score	0.027987 (rank : 136)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	134	Target Neighborhood Hits	893	Shared Neighborhood Hits	24
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

AIM1_HUMAN
NC score	0.027564 (rank : 137)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	134	Target Neighborhood Hits	247	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

K0423_HUMAN
NC score	0.027013 (rank : 138)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	134	Target Neighborhood Hits	171	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F4, Q68D66, Q6PG27	Gene names	KIAA0423
Domain Architecture	No domain graphic available
Description	Protein KIAA0423.

E2F4_HUMAN
NC score	0.026716 (rank : 139)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	134	Target Neighborhood Hits	188	Shared Neighborhood Hits	5
SwissProt Accessions	Q16254, Q12991, Q15328	Gene names	E2F4
Domain Architecture
Description	Transcription factor E2F4 (E2F-4).

CYLC1_HUMAN
NC score	0.025662 (rank : 140)	θ value	1.06291 (rank : 73)
Query Neighborhood Hits	134	Target Neighborhood Hits	408	Shared Neighborhood Hits	13
SwissProt Accessions	P35663, Q5JQQ9	Gene names	CYLC1, CYL, CYL1
Domain Architecture	No domain graphic available
Description	Cylicin-1 (Cylicin I) (Multiple-band polypeptide I).

MBD6_HUMAN
NC score	0.025464 (rank : 141)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	134	Target Neighborhood Hits	349	Shared Neighborhood Hits	9
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MYST4_HUMAN
NC score	0.025257 (rank : 142)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	134	Target Neighborhood Hits	671	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

CA103_MOUSE
NC score	0.022709 (rank : 143)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	134	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CDD9, Q8C893	Gene names
Domain Architecture	No domain graphic available
Description	Protein C1orf103 homolog.

SAMN1_MOUSE
NC score	0.022419 (rank : 144)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	134	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

CCD82_HUMAN
NC score	0.020274 (rank : 145)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	134	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N4S0, Q9H2Q5, Q9H5E3	Gene names	CCDC82
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 82.

WDTC1_HUMAN
NC score	0.019923 (rank : 146)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	134	Target Neighborhood Hits	299	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N5D0, Q9NV87, Q9UPW4	Gene names	WDTC1, KIAA1037
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

WDTC1_MOUSE
NC score	0.019787 (rank : 147)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	134	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ZK9	Gene names	Wdtc1
Domain Architecture
Description	WD and tetratricopeptide repeats protein 1.

ZHX2_MOUSE
NC score	0.019776 (rank : 148)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	134	Target Neighborhood Hits	435	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

DAB2_MOUSE
NC score	0.019491 (rank : 149)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	134	Target Neighborhood Hits	163	Shared Neighborhood Hits	6
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

AFF4_HUMAN
NC score	0.019473 (rank : 150)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	134	Target Neighborhood Hits	611	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

NOL4_MOUSE
NC score	0.018673 (rank : 151)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	134	Target Neighborhood Hits	44	Shared Neighborhood Hits	6
SwissProt Accessions	P60954	Gene names	Nol4
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4.

HSF1_MOUSE
NC score	0.018641 (rank : 152)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	134	Target Neighborhood Hits	267	Shared Neighborhood Hits	10
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

CCDC4_HUMAN
NC score	0.018636 (rank : 153)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	134	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

SET1A_HUMAN
NC score	0.018147 (rank : 154)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	134	Target Neighborhood Hits	690	Shared Neighborhood Hits	22
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

BTBDC_HUMAN
NC score	0.016426 (rank : 155)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	134	Target Neighborhood Hits	248	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

EVI2B_MOUSE
NC score	0.016198 (rank : 156)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	134	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VD58, Q3U1A3	Gene names	Evi2b
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

BAT2_MOUSE
NC score	0.016116 (rank : 157)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	134	Target Neighborhood Hits	947	Shared Neighborhood Hits	17
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SOX6_MOUSE
NC score	0.015945 (rank : 158)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	134	Target Neighborhood Hits	341	Shared Neighborhood Hits	9
SwissProt Accessions	P40645, Q62250, Q9QWS5	Gene names	Sox6, Sox-6
Domain Architecture
Description	Transcription factor SOX-6 (SOX-LZ).

IDUA_HUMAN
NC score	0.015036 (rank : 159)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	134	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P35475	Gene names	IDUA
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

IDUA_MOUSE
NC score	0.014956 (rank : 160)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	134	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	P48441	Gene names	Idua
Domain Architecture
Description	Alpha-L-iduronidase precursor (EC 3.2.1.76).

MOCS3_HUMAN
NC score	0.014898 (rank : 161)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	134	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	O95396	Gene names	MOCS3
Domain Architecture
Description	Molybdenum cofactor synthesis protein 3 (Molybdopterin synthase sulfurylase) (MPT synthase sulfurylase).

RIMS2_MOUSE
NC score	0.013641 (rank : 162)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	134	Target Neighborhood Hits	376	Shared Neighborhood Hits	11
SwissProt Accessions	Q9EQZ7, Q8C433, Q8CCK2	Gene names	Rims2, Rab3ip2, Rim2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2) (Rab3-interacting protein 2).

ARID2_HUMAN
NC score	0.013421 (rank : 163)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	134	Target Neighborhood Hits	302	Shared Neighborhood Hits	12
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

UBP10_HUMAN
NC score	0.013059 (rank : 164)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	6
SwissProt Accessions	Q14694, Q9BWG7, Q9NSL7	Gene names	USP10, KIAA0190
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

JHD2C_HUMAN
NC score	0.012567 (rank : 165)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	134	Target Neighborhood Hits	279	Shared Neighborhood Hits	14
SwissProt Accessions	Q15652, Q5SQZ8, Q5SQZ9, Q5SR00, Q7Z3E7, Q8N3U0, Q96KB9, Q9P2G7	Gene names	JMJD1C, JHDM2C, KIAA1380, TRIP8
Domain Architecture	No domain graphic available
Description	Probable JmjC domain-containing histone demethylation protein 2C (EC 1.14.11.-) (Jumonji domain-containing protein 1C) (Thyroid receptor-interacting protein 8) (TRIP-8).

HELC1_HUMAN
NC score	0.012024 (rank : 166)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	134	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

STAP2_MOUSE
NC score	0.012000 (rank : 167)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	134	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

NCOR2_MOUSE
NC score	0.011455 (rank : 168)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	134	Target Neighborhood Hits	790	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

S13A4_HUMAN
NC score	0.011436 (rank : 169)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	134	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKG4	Gene names	SLC13A4, SUT1
Domain Architecture
Description	Solute carrier family 13 member 4 (Na(+)/sulfate cotransporter SUT-1).

ICAL_HUMAN
NC score	0.011237 (rank : 170)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	134	Target Neighborhood Hits	275	Shared Neighborhood Hits	6
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

RFX3_MOUSE
NC score	0.011217 (rank : 171)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	134	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	P48381, Q8BLW2, Q8C0R3, Q8VBY6	Gene names	Rfx3
Domain Architecture
Description	Transcription factor RFX3.

RFX3_HUMAN
NC score	0.011210 (rank : 172)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	134	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	P48380, Q5JTL7, Q5JTL8, Q6NW13, Q8WTU4, Q95HL5, Q95HL6	Gene names	RFX3
Domain Architecture
Description	Transcription factor RFX3.

RNF31_MOUSE
NC score	0.011030 (rank : 173)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	134	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	Q924T7	Gene names	Rnf31
Domain Architecture
Description	RING finger protein 31.

S28A2_MOUSE
NC score	0.010669 (rank : 174)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	134	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O88627	Gene names	Slc28a2, Cnt2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (Sodium/purine nucleoside cotransporter) (SPNT).

FA53B_HUMAN
NC score	0.010540 (rank : 175)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	134	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

UTY_MOUSE
NC score	0.009794 (rank : 176)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	134	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P79457, O97979	Gene names	Uty
Domain Architecture
Description	Ubiquitously transcribed Y chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein ON the Y chromosome) (Male- specific histocompatibility antigen H-YDB).

NEDD1_HUMAN
NC score	0.009089 (rank : 177)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	134	Target Neighborhood Hits	294	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NHV4, Q8NA30	Gene names	NEDD1
Domain Architecture	No domain graphic available
Description	Protein NEDD1.

THIC_MOUSE
NC score	0.007200 (rank : 178)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	134	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CAY6, Q3TJY7, Q62292, Q96EB7, Q99K88, Q9CYV2	Gene names	Acat2
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase).

CLH2_HUMAN
NC score	0.007175 (rank : 179)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	134	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	P53675, Q14017, Q15808, Q15809	Gene names	CLTCL1, CLH22, CLTCL, CLTD
Domain Architecture
Description	Clathrin heavy chain 2 (CLH-22).

IRF1_MOUSE
NC score	0.006363 (rank : 180)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	134	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P15314	Gene names	Irf1
Domain Architecture
Description	Interferon regulatory factor 1 (IRF-1).

HTF4_HUMAN
NC score	0.005846 (rank : 181)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	134	Target Neighborhood Hits	152	Shared Neighborhood Hits	4
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

CCNB1_HUMAN
NC score	0.005071 (rank : 182)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	134	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	P14635	Gene names	CCNB1, CCNB
Domain Architecture
Description	G2/mitotic-specific cyclin-B1.

EYA4_HUMAN
NC score	0.004938 (rank : 183)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	134	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O95677, O95464, O95679, Q8IW39, Q9NTR7	Gene names	EYA4
Domain Architecture
Description	Eyes absent homolog 4 (EC 3.1.3.48).

ATP4A_MOUSE
NC score	0.003532 (rank : 184)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	134	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q64436, Q9CV46	Gene names	Atp4a
Domain Architecture
Description	Potassium-transporting ATPase alpha chain 1 (EC 3.6.3.10) (Proton pump) (Gastric H+/K+ ATPase subunit alpha).

FLRT3_HUMAN
NC score	0.003017 (rank : 185)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	134	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZU0, Q96K39, Q96K42, Q96KB1, Q9P259	Gene names	FLRT3, KIAA1469
Domain Architecture
Description	Leucine-rich repeat transmembrane protein FLRT3 precursor (Fibronectin-like domain-containing leucine-rich transmembrane protein 3).

ADA29_HUMAN
NC score	0.002647 (rank : 186)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	134	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

CSMD3_HUMAN
NC score	0.002289 (rank : 187)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	134	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z407, Q96PZ3	Gene names	CSMD3, KIAA1894
Domain Architecture
Description	CUB and sushi domain-containing protein 3 precursor (CUB and sushi multiple domains protein 3).

KS6A5_HUMAN
NC score	0.000949 (rank : 188)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	134	Target Neighborhood Hits	855	Shared Neighborhood Hits	5
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
NC score	0.000820 (rank : 189)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	134	Target Neighborhood Hits	854	Shared Neighborhood Hits	5
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

TRI10_HUMAN
NC score	0.000731 (rank : 190)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	134	Target Neighborhood Hits	315	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

PTN13_MOUSE
NC score	0.000060 (rank : 191)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	134	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

PCDBG_HUMAN
NC score	0.000040 (rank : 192)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	134	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NRJ7, Q8IYD5, Q96SE9, Q9HCF1	Gene names	PCDHB16, KIAA1621, PCDH3X
Domain Architecture
Description	Protocadherin beta 16 precursor (PCDH-beta16) (Protocadherin 3X).

TITIN_HUMAN
NC score	-0.001074 (rank : 193)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	134	Target Neighborhood Hits	2923	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ZBT38_HUMAN
NC score	-0.001820 (rank : 194)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	134	Target Neighborhood Hits	885	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NAP3	Gene names	ZBTB38
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 38.

MK07_MOUSE
NC score	-0.001854 (rank : 195)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	134	Target Neighborhood Hits	1054	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

ZBT24_MOUSE
NC score	-0.003897 (rank : 196)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	134	Target Neighborhood Hits	894	Shared Neighborhood Hits	7
SwissProt Accessions	Q80X44, Q3UIB7, Q7TPC4, Q8CJC9	Gene names	Zbtb24, Bif1, Bsg1, Znf450
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) (Bone morphogenetic protein-induced factor 1) (Brain-specific protein 1).

ZNF18_MOUSE
NC score	-0.004238 (rank : 197)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	134	Target Neighborhood Hits	743	Shared Neighborhood Hits	4
SwissProt Accessions	Q810A1, Q9D972	Gene names	Znf18, Zfp535
Domain Architecture	No domain graphic available
Description	Zinc finger protein 18 (Zinc finger protein 535).