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Network neighborhood for query Sequence : THIC_MOUSE

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THIC_MOUSE
SwissProt Accessions	Q8CAY6, Q3TJY7, Q62292, Q96EB7, Q99K88, Q9CYV2	Gene names	Acat2
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

THIC_HUMAN
θ value	0 (rank : 1)	NC score	0.999416 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BWD1, Q16146, Q5TCL7, Q8TDM4	Gene names	ACAT2, ACTL
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) (Acetyl CoA transferase-like protein).

THIC_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CAY6, Q3TJY7, Q62292, Q96EB7, Q99K88, Q9CYV2	Gene names	Acat2
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase).

THIL_HUMAN
θ value	1.00358e-83 (rank : 3)	NC score	0.971366 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	P24752	Gene names	ACAT1, ACAT, MAT
Domain Architecture
Description	Acetyl-CoA acetyltransferase, mitochondrial precursor (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2).

THIL_MOUSE
θ value	1.31072e-83 (rank : 4)	NC score	0.972745 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q8QZT1, Q3TE92	Gene names	Acat1
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, mitochondrial precursor (EC 2.3.1.9) (Acetoacetyl-CoA thiolase).

THIM_HUMAN
θ value	1.14825e-79 (rank : 5)	NC score	0.972327 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42765, Q9BUT6	Gene names	ACAA2
Domain Architecture
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase) (T1).

THIM_MOUSE
θ value	1.65806e-78 (rank : 6)	NC score	0.970457 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BWT1, Q8JZR8	Gene names	Acaa2
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase).

THIKB_MOUSE
θ value	1.36269e-64 (rank : 7)	NC score	0.945827 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCH0	Gene names	Acaa1b, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase B, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl- CoA thiolase B).

THIKA_MOUSE
θ value	9.76566e-63 (rank : 8)	NC score	0.945194 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q921H8	Gene names	Acaa1a, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase A, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase A) (Acetyl-CoA acyltransferase A) (Peroxisomal 3-oxoacyl- CoA thiolase A).

THIK_HUMAN
θ value	1.27544e-62 (rank : 9)	NC score	0.945809 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P09110	Gene names	ACAA1, ACAA, PTHIO
Domain Architecture
Description	3-ketoacyl-CoA thiolase, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Peroxisomal 3-oxoacyl-CoA thiolase).

ECHB_MOUSE
θ value	8.59492e-43 (rank : 10)	NC score	0.913054 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

ECHB_HUMAN
θ value	1.91475e-42 (rank : 11)	NC score	0.913655 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

NLTP_HUMAN
θ value	1.99992e-07 (rank : 12)	NC score	0.481579 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P22307, Q15432, Q16622, Q99430	Gene names	SCP2
Domain Architecture
Description	Nonspecific lipid-transfer protein (EC 2.3.1.176) (Propanoyl-CoA C- acyltransferase) (NSL-TP) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (SCP-chi) (SCPX).

NLTP_MOUSE
θ value	2.21117e-06 (rank : 13)	NC score	0.488252 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P32020, Q9DBM7	Gene names	Scp2, Scp-2
Domain Architecture
Description	Nonspecific lipid-transfer protein (EC 2.3.1.176) (Propanoyl-CoA C- acyltransferase) (NSL-TP) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (SCP-chi) (SCPX).

DCAK3_HUMAN
θ value	6.88961 (rank : 14)	NC score	-0.001845 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	888	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

IF_MOUSE
θ value	6.88961 (rank : 15)	NC score	0.010527 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P52787	Gene names	Gif
Domain Architecture
Description	Gastric intrinsic factor precursor (Intrinsic factor) (IF) (INF).

NFM_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.000587 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1328	Shared Neighborhood Hits	3
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NFM_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.000766 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1159	Shared Neighborhood Hits	4
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

ZFYV9_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.007200 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

Hits sorted by NC score

THIC_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CAY6, Q3TJY7, Q62292, Q96EB7, Q99K88, Q9CYV2	Gene names	Acat2
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase).

THIC_HUMAN
NC score	0.999416 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BWD1, Q16146, Q5TCL7, Q8TDM4	Gene names	ACAT2, ACTL
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) (Acetyl CoA transferase-like protein).

THIL_MOUSE
NC score	0.972745 (rank : 3)	θ value	1.31072e-83 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q8QZT1, Q3TE92	Gene names	Acat1
Domain Architecture	No domain graphic available
Description	Acetyl-CoA acetyltransferase, mitochondrial precursor (EC 2.3.1.9) (Acetoacetyl-CoA thiolase).

THIM_HUMAN
NC score	0.972327 (rank : 4)	θ value	1.14825e-79 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P42765, Q9BUT6	Gene names	ACAA2
Domain Architecture
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase) (T1).

THIL_HUMAN
NC score	0.971366 (rank : 5)	θ value	1.00358e-83 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	P24752	Gene names	ACAT1, ACAT, MAT
Domain Architecture
Description	Acetyl-CoA acetyltransferase, mitochondrial precursor (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2).

THIM_MOUSE
NC score	0.970457 (rank : 6)	θ value	1.65806e-78 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BWT1, Q8JZR8	Gene names	Acaa2
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Mitochondrial 3-oxoacyl- CoA thiolase).

THIKB_MOUSE
NC score	0.945827 (rank : 7)	θ value	1.36269e-64 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VCH0	Gene names	Acaa1b, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase B, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase B) (Acetyl-CoA acyltransferase B) (Peroxisomal 3-oxoacyl- CoA thiolase B).

THIK_HUMAN
NC score	0.945809 (rank : 8)	θ value	1.27544e-62 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	16	Shared Neighborhood Hits	13
SwissProt Accessions	P09110	Gene names	ACAA1, ACAA, PTHIO
Domain Architecture
Description	3-ketoacyl-CoA thiolase, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase) (Acetyl-CoA acyltransferase) (Peroxisomal 3-oxoacyl-CoA thiolase).

THIKA_MOUSE
NC score	0.945194 (rank : 9)	θ value	9.76566e-63 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	17	Shared Neighborhood Hits	13
SwissProt Accessions	Q921H8	Gene names	Acaa1a, Acaa1
Domain Architecture	No domain graphic available
Description	3-ketoacyl-CoA thiolase A, peroxisomal precursor (EC 2.3.1.16) (Beta- ketothiolase A) (Acetyl-CoA acyltransferase A) (Peroxisomal 3-oxoacyl- CoA thiolase A).

ECHB_HUMAN
NC score	0.913655 (rank : 10)	θ value	1.91475e-42 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	P55084, O14969, Q53TA6, Q96C77, Q9H3F5	Gene names	HADHB
Domain Architecture
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

ECHB_MOUSE
NC score	0.913054 (rank : 11)	θ value	8.59492e-43 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q99JY0, Q3TEH9, Q8BJI5, Q8BJM0, Q8BK52	Gene names	Hadhb
Domain Architecture	No domain graphic available
Description	Trifunctional enzyme subunit beta, mitochondrial precursor (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)].

NLTP_MOUSE
NC score	0.488252 (rank : 12)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P32020, Q9DBM7	Gene names	Scp2, Scp-2
Domain Architecture
Description	Nonspecific lipid-transfer protein (EC 2.3.1.176) (Propanoyl-CoA C- acyltransferase) (NSL-TP) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (SCP-chi) (SCPX).

NLTP_HUMAN
NC score	0.481579 (rank : 13)	θ value	1.99992e-07 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P22307, Q15432, Q16622, Q99430	Gene names	SCP2
Domain Architecture
Description	Nonspecific lipid-transfer protein (EC 2.3.1.176) (Propanoyl-CoA C- acyltransferase) (NSL-TP) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X) (SCP-chi) (SCPX).

IF_MOUSE
NC score	0.010527 (rank : 14)	θ value	6.88961 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P52787	Gene names	Gif
Domain Architecture
Description	Gastric intrinsic factor precursor (Intrinsic factor) (IF) (INF).

ZFYV9_HUMAN
NC score	0.007200 (rank : 15)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

NFM_MOUSE
NC score	0.000766 (rank : 16)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	1159	Shared Neighborhood Hits	4
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NFM_HUMAN
NC score	0.000587 (rank : 17)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	1328	Shared Neighborhood Hits	3
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

DCAK3_HUMAN
NC score	-0.001845 (rank : 18)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	888	Shared Neighborhood Hits	3
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).