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Network neighborhood for query Sequence : STAP2_MOUSE

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STAP2_MOUSE
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

STAP2_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

STAP2_HUMAN
θ value	1.63136e-134 (rank : 2)	NC score	0.977047 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

STAP1_HUMAN
θ value	1.28434e-38 (rank : 3)	NC score	0.836040 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

STAP1_MOUSE
θ value	1.08726e-37 (rank : 4)	NC score	0.833047 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

PLCG2_HUMAN
θ value	0.00102713 (rank : 5)	NC score	0.097072 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BLK_MOUSE
θ value	0.00509761 (rank : 6)	NC score	0.041593 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	992	Shared Neighborhood Hits	15
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SRMS_MOUSE
θ value	0.0252991 (rank : 7)	NC score	0.041207 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	964	Shared Neighborhood Hits	15
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

DDEF1_MOUSE
θ value	0.0330416 (rank : 8)	NC score	0.044102 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	592	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

SRMS_HUMAN
θ value	0.0330416 (rank : 9)	NC score	0.042208 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BLK_HUMAN
θ value	0.0563607 (rank : 10)	NC score	0.038792 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	994	Shared Neighborhood Hits	14
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PCLO_HUMAN
θ value	0.0563607 (rank : 11)	NC score	0.032202 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	2046	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

AKA11_HUMAN
θ value	0.365318 (rank : 12)	NC score	0.062531 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

ERBB2_HUMAN
θ value	0.62314 (rank : 13)	NC score	0.035270 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	1073	Shared Neighborhood Hits	15
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ITK_MOUSE
θ value	0.62314 (rank : 14)	NC score	0.031681 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	985	Shared Neighborhood Hits	15
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

FRK_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.032472 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	1058	Shared Neighborhood Hits	14
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

CEND1_HUMAN
θ value	1.38821 (rank : 16)	NC score	0.037260 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	284	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

FARP2_HUMAN
θ value	1.38821 (rank : 17)	NC score	0.023965 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	240	Shared Neighborhood Hits	7
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CEND1_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.036789 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

LCK_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.034000 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	987	Shared Neighborhood Hits	13
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLNK_MOUSE
θ value	2.36792 (rank : 20)	NC score	0.044192 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

ERBB2_MOUSE
θ value	2.36792 (rank : 21)	NC score	0.031919 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	918	Shared Neighborhood Hits	12
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

GGA2_HUMAN
θ value	2.36792 (rank : 22)	NC score	0.020535 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

IDD_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.025145 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	151	Shared Neighborhood Hits	2
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

LCK_MOUSE
θ value	2.36792 (rank : 24)	NC score	0.033568 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	981	Shared Neighborhood Hits	13
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SON_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.019180 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

FARP1_HUMAN
θ value	3.0926 (rank : 26)	NC score	0.022270 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_MOUSE
θ value	3.0926 (rank : 27)	NC score	0.022052 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	209	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

NACAM_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.019900 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	1866	Shared Neighborhood Hits	13
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SACS_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.031382 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

CBL_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.018346 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	353	Shared Neighborhood Hits	6
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

FOXO4_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.009549 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

NCK1_HUMAN
θ value	5.27518 (rank : 32)	NC score	0.043572 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	312	Shared Neighborhood Hits	14
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SACS_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.030324 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

LCP2_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.027305 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	531	Shared Neighborhood Hits	11
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

ZFYV9_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.012000 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

K0174_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.015961 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

K1802_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.009190 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	1378	Shared Neighborhood Hits	11
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYO15_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.006068 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	467	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SSH1_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.011077 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

SSH2_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.010581 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

TF3C3_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.017109 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Q9, Q86XJ8, Q8WX84, Q96B44, Q9H5I8, Q9NT97	Gene names	GTF3C3
Domain Architecture
Description	General transcription factor 3C polypeptide 3 (Transcription factor IIIC-subunit gamma) (TF3C-gamma) (TFIIIC 102 kDa subunit) (TFIIIC102).

SLAP1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.053013 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.053659 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.055427 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.058417 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	136	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

Hits sorted by NC score

STAP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

STAP2_HUMAN
NC score	0.977047 (rank : 2)	θ value	1.63136e-134 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

STAP1_HUMAN
NC score	0.836040 (rank : 3)	θ value	1.28434e-38 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ULZ2	Gene names	STAP1, BRDG1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1) (BCR downstream signaling protein 1) (Docking protein BRDG1).

STAP1_MOUSE
NC score	0.833047 (rank : 4)	θ value	1.08726e-37 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9JM90, Q3TRM1, Q6PES6	Gene names	Stap1
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 1 (STAP-1) (Stem cell adaptor protein 1).

PLCG2_HUMAN
NC score	0.097072 (rank : 5)	θ value	0.00102713 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	280	Shared Neighborhood Hits	16
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

AKA11_HUMAN
NC score	0.062531 (rank : 6)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	57	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UKA4, O75124, Q9NUK7	Gene names	AKAP11, AKAP220, KIAA0629
Domain Architecture
Description	A-kinase anchor protein 11 (Protein kinase A-anchoring protein 11) (PRKA11) (A kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220).

SLAP2_MOUSE
NC score	0.058417 (rank : 7)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	41	Target Neighborhood Hits	136	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.055427 (rank : 8)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	41	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_MOUSE
NC score	0.053659 (rank : 9)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	41	Target Neighborhood Hits	117	Shared Neighborhood Hits	10
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP1_HUMAN
NC score	0.053013 (rank : 10)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	113	Shared Neighborhood Hits	10
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BLNK_MOUSE
NC score	0.044192 (rank : 11)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	296	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

DDEF1_MOUSE
NC score	0.044102 (rank : 12)	θ value	0.0330416 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	592	Shared Neighborhood Hits	11
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NCK1_HUMAN
NC score	0.043572 (rank : 13)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	312	Shared Neighborhood Hits	14
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SRMS_HUMAN
NC score	0.042208 (rank : 14)	θ value	0.0330416 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

BLK_MOUSE
NC score	0.041593 (rank : 15)	θ value	0.00509761 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	992	Shared Neighborhood Hits	15
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SRMS_MOUSE
NC score	0.041207 (rank : 16)	θ value	0.0252991 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	964	Shared Neighborhood Hits	15
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

BLK_HUMAN
NC score	0.038792 (rank : 17)	θ value	0.0563607 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	994	Shared Neighborhood Hits	14
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CEND1_HUMAN
NC score	0.037260 (rank : 18)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	284	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND1_MOUSE
NC score	0.036789 (rank : 19)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

ERBB2_HUMAN
NC score	0.035270 (rank : 20)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	1073	Shared Neighborhood Hits	15
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

LCK_HUMAN
NC score	0.034000 (rank : 21)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	987	Shared Neighborhood Hits	13
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
NC score	0.033568 (rank : 22)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	981	Shared Neighborhood Hits	13
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

FRK_HUMAN
NC score	0.032472 (rank : 23)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	1058	Shared Neighborhood Hits	14
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PCLO_HUMAN
NC score	0.032202 (rank : 24)	θ value	0.0563607 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	2046	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

ERBB2_MOUSE
NC score	0.031919 (rank : 25)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	918	Shared Neighborhood Hits	12
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ITK_MOUSE
NC score	0.031681 (rank : 26)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	985	Shared Neighborhood Hits	15
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SACS_MOUSE
NC score	0.031382 (rank : 27)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLC8	Gene names	Sacs
Domain Architecture
Description	Sacsin.

SACS_HUMAN
NC score	0.030324 (rank : 28)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	128	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

LCP2_HUMAN
NC score	0.027305 (rank : 29)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	531	Shared Neighborhood Hits	11
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

IDD_MOUSE
NC score	0.025145 (rank : 30)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	151	Shared Neighborhood Hits	2
SwissProt Accessions	P98154, Q61844	Gene names	Dgcr2, Dgsc, Idd, Sez-12, Sez12
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor (Seizure-related membrane-bound adhesion protein).

FARP2_HUMAN
NC score	0.023965 (rank : 31)	θ value	1.38821 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	240	Shared Neighborhood Hits	7
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
NC score	0.022270 (rank : 32)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	241	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_MOUSE
NC score	0.022052 (rank : 33)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	209	Shared Neighborhood Hits	8
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GGA2_HUMAN
NC score	0.020535 (rank : 34)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

NACAM_MOUSE
NC score	0.019900 (rank : 35)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	1866	Shared Neighborhood Hits	13
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SON_HUMAN
NC score	0.019180 (rank : 36)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	1568	Shared Neighborhood Hits	11
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CBL_HUMAN
NC score	0.018346 (rank : 37)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	353	Shared Neighborhood Hits	6
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

TF3C3_HUMAN
NC score	0.017109 (rank : 38)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Q9, Q86XJ8, Q8WX84, Q96B44, Q9H5I8, Q9NT97	Gene names	GTF3C3
Domain Architecture
Description	General transcription factor 3C polypeptide 3 (Transcription factor IIIC-subunit gamma) (TF3C-gamma) (TFIIIC 102 kDa subunit) (TFIIIC102).

K0174_MOUSE
NC score	0.015961 (rank : 39)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX00, Q80U68	Gene names	Kiaa0174
Domain Architecture	No domain graphic available
Description	Protein KIAA0174.

ZFYV9_HUMAN
NC score	0.012000 (rank : 40)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

SSH1_HUMAN
NC score	0.011077 (rank : 41)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	164	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WYL5, Q6P6C0, Q8N9A7, Q8WYL3, Q8WYL4, Q9P2P8	Gene names	SSH1, KIAA1298, SSH1L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 1 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-1L) (hSSH-1L).

SSH2_HUMAN
NC score	0.010581 (rank : 42)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q76I76, Q8TDB5, Q8WYL1, Q8WYL2, Q96F40, Q96H36, Q9C0D8	Gene names	SSH2, KIAA1725, SSH2L
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (hSSH-2L).

FOXO4_MOUSE
NC score	0.009549 (rank : 43)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	168	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVH3	Gene names	Mllt7, Afx, Afx1, Fkhr3, Foxo4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Afxh) (Forkhead box protein O4).

K1802_HUMAN
NC score	0.009190 (rank : 44)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	1378	Shared Neighborhood Hits	11
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MYO15_MOUSE
NC score	0.006068 (rank : 45)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	467	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).