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Network neighborhood for query Sequence : ZFY16_MOUSE

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ZFY16_MOUSE
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ZFY16_HUMAN
θ value	0 (rank : 1)	NC score	0.983444 (rank : 2)
Query Neighborhood Hits	108	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFY16_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	108
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFYV9_HUMAN
θ value	4.40161e-164 (rank : 3)	NC score	0.945409 (rank : 3)
Query Neighborhood Hits	108	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

FGD6_HUMAN
θ value	1.63225e-17 (rank : 4)	NC score	0.553287 (rank : 12)
Query Neighborhood Hits	108	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	2.7842e-17 (rank : 5)	NC score	0.544016 (rank : 15)
Query Neighborhood Hits	108	Target Neighborhood Hits	282	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

HGS_MOUSE
θ value	2.20605e-14 (rank : 6)	NC score	0.541169 (rank : 17)
Query Neighborhood Hits	108	Target Neighborhood Hits	589	Shared Neighborhood Hits	59
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
θ value	6.41864e-14 (rank : 7)	NC score	0.541118 (rank : 18)
Query Neighborhood Hits	108	Target Neighborhood Hits	517	Shared Neighborhood Hits	57
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

ZFY21_MOUSE
θ value	1.09485e-13 (rank : 8)	NC score	0.735518 (rank : 4)
Query Neighborhood Hits	108	Target Neighborhood Hits	72	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FGD1_MOUSE
θ value	4.16044e-13 (rank : 9)	NC score	0.469357 (rank : 27)
Query Neighborhood Hits	108	Target Neighborhood Hits	387	Shared Neighborhood Hits	52
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZFY21_HUMAN
θ value	7.09661e-13 (rank : 10)	NC score	0.727552 (rank : 5)
Query Neighborhood Hits	108	Target Neighborhood Hits	72	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

FGD5_HUMAN
θ value	2.0648e-12 (rank : 11)	NC score	0.547509 (rank : 13)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD1_HUMAN
θ value	2.69671e-12 (rank : 12)	NC score	0.468496 (rank : 28)
Query Neighborhood Hits	108	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_HUMAN
θ value	7.84624e-12 (rank : 13)	NC score	0.473666 (rank : 24)
Query Neighborhood Hits	108	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FYCO1_HUMAN
θ value	1.02475e-11 (rank : 14)	NC score	0.273590 (rank : 45)
Query Neighborhood Hits	108	Target Neighborhood Hits	1149	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

FYV1_HUMAN
θ value	1.02475e-11 (rank : 15)	NC score	0.511108 (rank : 20)
Query Neighborhood Hits	108	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	1.02475e-11 (rank : 16)	NC score	0.511156 (rank : 19)
Query Neighborhood Hits	108	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

MTMR3_HUMAN
θ value	1.33837e-11 (rank : 17)	NC score	0.395152 (rank : 34)
Query Neighborhood Hits	108	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PKHF2_HUMAN
θ value	1.33837e-11 (rank : 18)	NC score	0.669434 (rank : 8)
Query Neighborhood Hits	108	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	1.33837e-11 (rank : 19)	NC score	0.669972 (rank : 7)
Query Neighborhood Hits	108	Target Neighborhood Hits	77	Shared Neighborhood Hits	48
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

FGD4_MOUSE
θ value	2.28291e-11 (rank : 20)	NC score	0.469770 (rank : 26)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD5_MOUSE
θ value	2.28291e-11 (rank : 21)	NC score	0.555372 (rank : 11)
Query Neighborhood Hits	108	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD2_MOUSE
θ value	3.89403e-11 (rank : 22)	NC score	0.493094 (rank : 21)
Query Neighborhood Hits	108	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
θ value	5.08577e-11 (rank : 23)	NC score	0.492522 (rank : 22)
Query Neighborhood Hits	108	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

RUFY1_MOUSE
θ value	8.67504e-11 (rank : 24)	NC score	0.382899 (rank : 36)
Query Neighborhood Hits	108	Target Neighborhood Hits	765	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_HUMAN
θ value	1.133e-10 (rank : 25)	NC score	0.301276 (rank : 44)
Query Neighborhood Hits	108	Target Neighborhood Hits	1208	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

EEA1_MOUSE
θ value	1.9326e-10 (rank : 26)	NC score	0.229345 (rank : 49)
Query Neighborhood Hits	108	Target Neighborhood Hits	1637	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

RUFY1_HUMAN
θ value	1.9326e-10 (rank : 27)	NC score	0.374885 (rank : 40)
Query Neighborhood Hits	108	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY2_MOUSE
θ value	2.52405e-10 (rank : 28)	NC score	0.377539 (rank : 38)
Query Neighborhood Hits	108	Target Neighborhood Hits	820	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ZFY28_HUMAN
θ value	2.52405e-10 (rank : 29)	NC score	0.681424 (rank : 6)
Query Neighborhood Hits	108	Target Neighborhood Hits	152	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

EEA1_HUMAN
θ value	5.62301e-10 (rank : 30)	NC score	0.211387 (rank : 50)
Query Neighborhood Hits	108	Target Neighborhood Hits	1796	Shared Neighborhood Hits	67
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

WDFY3_MOUSE
θ value	1.25267e-09 (rank : 31)	NC score	0.378526 (rank : 37)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
θ value	1.63604e-09 (rank : 32)	NC score	0.376883 (rank : 39)
Query Neighborhood Hits	108	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

PKHF1_MOUSE
θ value	2.13673e-09 (rank : 33)	NC score	0.652996 (rank : 10)
Query Neighborhood Hits	108	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
θ value	2.79066e-09 (rank : 34)	NC score	0.656874 (rank : 9)
Query Neighborhood Hits	108	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

FYCO1_MOUSE
θ value	1.38499e-08 (rank : 35)	NC score	0.252759 (rank : 47)
Query Neighborhood Hits	108	Target Neighborhood Hits	1059	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANFY1_MOUSE
θ value	2.36244e-08 (rank : 36)	NC score	0.256324 (rank : 46)
Query Neighborhood Hits	108	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ZFYV1_HUMAN
θ value	2.61198e-07 (rank : 37)	NC score	0.544803 (rank : 14)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	3.41135e-07 (rank : 38)	NC score	0.541200 (rank : 16)
Query Neighborhood Hits	108	Target Neighborhood Hits	153	Shared Neighborhood Hits	59
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ANFY1_HUMAN
θ value	4.45536e-07 (rank : 39)	NC score	0.251186 (rank : 48)
Query Neighborhood Hits	108	Target Neighborhood Hits	480	Shared Neighborhood Hits	53
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FGD3_HUMAN
θ value	3.77169e-06 (rank : 40)	NC score	0.429793 (rank : 31)
Query Neighborhood Hits	108	Target Neighborhood Hits	249	Shared Neighborhood Hits	54
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

RBNS5_HUMAN
θ value	4.92598e-06 (rank : 41)	NC score	0.475471 (rank : 23)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	4.92598e-06 (rank : 42)	NC score	0.472220 (rank : 25)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

WDFY2_HUMAN
θ value	1.09739e-05 (rank : 43)	NC score	0.363340 (rank : 43)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	1.09739e-05 (rank : 44)	NC score	0.366158 (rank : 42)
Query Neighborhood Hits	108	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY1_HUMAN
θ value	1.43324e-05 (rank : 45)	NC score	0.372601 (rank : 41)
Query Neighborhood Hits	108	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ZFY27_MOUSE
θ value	4.1701e-05 (rank : 46)	NC score	0.407023 (rank : 32)
Query Neighborhood Hits	108	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FGD3_MOUSE
θ value	9.29e-05 (rank : 47)	NC score	0.390614 (rank : 35)
Query Neighborhood Hits	108	Target Neighborhood Hits	257	Shared Neighborhood Hits	55
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

ZFY19_HUMAN
θ value	0.000461057 (rank : 48)	NC score	0.460419 (rank : 29)
Query Neighborhood Hits	108	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY27_HUMAN
θ value	0.000602161 (rank : 49)	NC score	0.399693 (rank : 33)
Query Neighborhood Hits	108	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY19_MOUSE
θ value	0.00390308 (rank : 50)	NC score	0.452300 (rank : 30)
Query Neighborhood Hits	108	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

RFFL_MOUSE
θ value	0.0113563 (rank : 51)	NC score	0.189172 (rank : 51)
Query Neighborhood Hits	108	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
θ value	0.0431538 (rank : 52)	NC score	0.175987 (rank : 54)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

MIRO2_MOUSE
θ value	0.0563607 (rank : 53)	NC score	0.026073 (rank : 122)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8JZN7	Gene names	Rhot2, Arht2
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 2 (EC 3.6.5.-) (MIRO-2) (Ras homolog gene family member T2).

RNF34_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.176997 (rank : 53)
Query Neighborhood Hits	108	Target Neighborhood Hits	153	Shared Neighborhood Hits	33
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	0.163984 (rank : 55)	NC score	0.177403 (rank : 52)
Query Neighborhood Hits	108	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

ACINU_HUMAN
θ value	0.365318 (rank : 56)	NC score	0.022625 (rank : 125)
Query Neighborhood Hits	108	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

TEX2_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.035840 (rank : 118)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

ZN292_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.018469 (rank : 127)
Query Neighborhood Hits	108	Target Neighborhood Hits	918	Shared Neighborhood Hits	13
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

FSTL5_MOUSE
θ value	0.62314 (rank : 59)	NC score	0.015021 (rank : 131)
Query Neighborhood Hits	108	Target Neighborhood Hits	355	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

TACC2_HUMAN
θ value	0.62314 (rank : 60)	NC score	0.031592 (rank : 121)
Query Neighborhood Hits	108	Target Neighborhood Hits	856	Shared Neighborhood Hits	16
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

SP2_HUMAN
θ value	0.813845 (rank : 61)	NC score	0.006020 (rank : 146)
Query Neighborhood Hits	108	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q02086	Gene names	SP2, KIAA0048
Domain Architecture
Description	Transcription factor Sp2.

TTC17_HUMAN
θ value	0.813845 (rank : 62)	NC score	0.034371 (rank : 120)
Query Neighborhood Hits	108	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AE7	Gene names	TTC17
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 17 (TPR repeat protein 17).

TLR7_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.005463 (rank : 147)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYK1, Q9NR98	Gene names	TLR7
Domain Architecture
Description	Toll-like receptor 7 precursor.

CCD39_HUMAN
θ value	2.36792 (rank : 64)	NC score	0.039935 (rank : 116)
Query Neighborhood Hits	108	Target Neighborhood Hits	868	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

HOOK2_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.036296 (rank : 117)
Query Neighborhood Hits	108	Target Neighborhood Hits	714	Shared Neighborhood Hits	13
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

KIF4A_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.023440 (rank : 124)
Query Neighborhood Hits	108	Target Neighborhood Hits	1159	Shared Neighborhood Hits	17
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

OVOL1_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.003910 (rank : 150)
Query Neighborhood Hits	108	Target Neighborhood Hits	729	Shared Neighborhood Hits	18
SwissProt Accessions	O14753, Q6PCB1	Gene names	OVOL1
Domain Architecture	No domain graphic available
Description	Putative transcription factor Ovo-like 1 (hOvo1).

OVOL1_MOUSE
θ value	3.0926 (rank : 68)	NC score	0.004882 (rank : 148)
Query Neighborhood Hits	108	Target Neighborhood Hits	716	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTJ2, Q545S2	Gene names	Ovol1
Domain Architecture	No domain graphic available
Description	Putative transcription factor Ovo-like 1 (mOvo1) (mOvo1a).

TDRKH_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.015451 (rank : 130)
Query Neighborhood Hits	108	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

COA2_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.010713 (rank : 138)
Query Neighborhood Hits	108	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

FSTL5_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.011414 (rank : 136)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

GP137_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.018355 (rank : 128)
Query Neighborhood Hits	108	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q60865, Q60758, Q61620	Gene names	M11s1, Gpiap, Gpiap1, Gpip137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI).

SSH2_MOUSE
θ value	4.03905 (rank : 73)	NC score	0.007376 (rank : 142)
Query Neighborhood Hits	108	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

ZEP1_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.004263 (rank : 149)
Query Neighborhood Hits	108	Target Neighborhood Hits	1036	Shared Neighborhood Hits	19
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

EST1A_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.011032 (rank : 137)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

NEK11_MOUSE
θ value	5.27518 (rank : 76)	NC score	-0.003932 (rank : 168)
Query Neighborhood Hits	108	Target Neighborhood Hits	875	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NIPA_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.014598 (rank : 133)
Query Neighborhood Hits	108	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WB0, Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0	Gene names	ZC3HC1, NIPA
Domain Architecture	No domain graphic available
Description	Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1).

NU214_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.014804 (rank : 132)
Query Neighborhood Hits	108	Target Neighborhood Hits	657	Shared Neighborhood Hits	10
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

RINI_MOUSE
θ value	5.27518 (rank : 79)	NC score	0.006674 (rank : 143)
Query Neighborhood Hits	108	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

UBP1_HUMAN
θ value	5.27518 (rank : 80)	NC score	0.009006 (rank : 139)
Query Neighborhood Hits	108	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

ZN408_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.000778 (rank : 157)
Query Neighborhood Hits	108	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9D4	Gene names	ZNF408, PFM14, PRDM17
Domain Architecture	No domain graphic available
Description	Zinc finger protein 408 (PR-domain zinc finger protein 17).

CXA10_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.003875 (rank : 151)
Query Neighborhood Hits	108	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P57773, Q96KG0	Gene names	GJA10
Domain Architecture
Description	Gap junction alpha-10 protein (Connexin-59) (Cx59) (Connexin-58) (Cx58).

FATH_HUMAN
θ value	6.88961 (rank : 83)	NC score	-0.000813 (rank : 163)
Query Neighborhood Hits	108	Target Neighborhood Hits	570	Shared Neighborhood Hits	4
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

IF4G1_HUMAN
θ value	6.88961 (rank : 84)	NC score	0.008878 (rank : 140)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	6
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

MAZ_HUMAN
θ value	6.88961 (rank : 85)	NC score	0.001448 (rank : 152)
Query Neighborhood Hits	108	Target Neighborhood Hits	757	Shared Neighborhood Hits	16
SwissProt Accessions	P56270, Q15703, Q99443	Gene names	MAZ
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1) (ZF87) (ZIF87).

MAZ_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.001393 (rank : 153)
Query Neighborhood Hits	108	Target Neighborhood Hits	745	Shared Neighborhood Hits	16
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).

MINT_MOUSE
θ value	6.88961 (rank : 87)	NC score	0.012803 (rank : 135)
Query Neighborhood Hits	108	Target Neighborhood Hits	1514	Shared Neighborhood Hits	14
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PCDB1_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.000391 (rank : 159)
Query Neighborhood Hits	108	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5F3	Gene names	PCDHB1
Domain Architecture
Description	Protocadherin beta 1 precursor (PCDH-beta1).

RAB6A_HUMAN
θ value	6.88961 (rank : 89)	NC score	0.001208 (rank : 155)
Query Neighborhood Hits	108	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P20340, Q9UBE4	Gene names	RAB6A, RAB6
Domain Architecture
Description	Ras-related protein Rab-6A (Rab-6).

RAB6A_MOUSE
θ value	6.88961 (rank : 90)	NC score	0.001209 (rank : 154)
Query Neighborhood Hits	108	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35279, Q542M6, Q8R2Z7, Q8VEE5, Q9JJD4	Gene names	Rab6a, Rab6
Domain Architecture
Description	Ras-related protein Rab-6A (Rab-6).

RIMB2_MOUSE
θ value	6.88961 (rank : 91)	NC score	0.007977 (rank : 141)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

VEZF1_HUMAN
θ value	6.88961 (rank : 92)	NC score	0.001191 (rank : 156)
Query Neighborhood Hits	108	Target Neighborhood Hits	744	Shared Neighborhood Hits	16
SwissProt Accessions	Q14119	Gene names	VEZF1, DB1, ZNF161
Domain Architecture	No domain graphic available
Description	Vascular endothelial zinc finger 1 (Zinc finger protein 161) (Putative transcription factor DB1).

ZN230_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.000145 (rank : 160)
Query Neighborhood Hits	108	Target Neighborhood Hits	750	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UIE0, O15322, Q9P1U6	Gene names	ZNF230, FDZF2
Domain Architecture
Description	Zinc finger protein 230 (Zinc finger protein FDZF2).

ANK3_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.014333 (rank : 134)
Query Neighborhood Hits	108	Target Neighborhood Hits	853	Shared Neighborhood Hits	13
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CT2NL_MOUSE
θ value	8.99809 (rank : 95)	NC score	0.034979 (rank : 119)
Query Neighborhood Hits	108	Target Neighborhood Hits	902	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

LSHR_HUMAN
θ value	8.99809 (rank : 96)	NC score	-0.001153 (rank : 166)
Query Neighborhood Hits	108	Target Neighborhood Hits	731	Shared Neighborhood Hits	3
SwissProt Accessions	P22888, Q14751, Q15996, Q9UEW9	Gene names	LHCGR, LCGR, LGR2, LHRHR
Domain Architecture
Description	Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH- R) (Luteinizing hormone receptor) (LHR).

LYST_MOUSE
θ value	8.99809 (rank : 97)	NC score	0.049181 (rank : 115)
Query Neighborhood Hits	108	Target Neighborhood Hits	286	Shared Neighborhood Hits	7
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

MLL2_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.022624 (rank : 126)
Query Neighborhood Hits	108	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PTPRZ_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.000726 (rank : 158)
Query Neighborhood Hits	108	Target Neighborhood Hits	255	Shared Neighborhood Hits	2
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

RNF14_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.006119 (rank : 144)
Query Neighborhood Hits	108	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

TEX2_MOUSE
θ value	8.99809 (rank : 101)	NC score	0.023908 (rank : 123)
Query Neighborhood Hits	108	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPJ0	Gene names	Tex2, Kiaa1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

TITIN_HUMAN
θ value	8.99809 (rank : 102)	NC score	-0.002055 (rank : 167)
Query Neighborhood Hits	108	Target Neighborhood Hits	2923	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

UBR1_MOUSE
θ value	8.99809 (rank : 103)	NC score	0.006114 (rank : 145)
Query Neighborhood Hits	108	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

ZF64A_HUMAN
θ value	8.99809 (rank : 104)	NC score	-0.000914 (rank : 164)
Query Neighborhood Hits	108	Target Neighborhood Hits	737	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPA5, Q9NTS7, Q9NVH4	Gene names	ZFP64, ZNF338
Domain Architecture	No domain graphic available
Description	Zinc finger protein 64, isoforms 1 and 2 (Zinc finger protein 338).

ZF64B_HUMAN
θ value	8.99809 (rank : 105)	NC score	-0.001121 (rank : 165)
Query Neighborhood Hits	108	Target Neighborhood Hits	740	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTW7, Q8WU98, Q9H9P1	Gene names	ZFP64, ZNF338
Domain Architecture	No domain graphic available
Description	Zinc finger protein 64, isoforms 3 and 4 (Zinc finger protein 338).

ZFAN3_MOUSE
θ value	8.99809 (rank : 106)	NC score	0.017993 (rank : 129)
Query Neighborhood Hits	108	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

ZFY1_MOUSE
θ value	8.99809 (rank : 107)	NC score	-0.000112 (rank : 162)
Query Neighborhood Hits	108	Target Neighborhood Hits	790	Shared Neighborhood Hits	17
SwissProt Accessions	P10925	Gene names	Zfy1, Zfy-1
Domain Architecture
Description	Zinc finger Y-chromosomal protein 1.

ZN699_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.000005 (rank : 161)
Query Neighborhood Hits	108	Target Neighborhood Hits	773	Shared Neighborhood Hits	24
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).

ABR_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.084993 (rank : 83)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ALS2_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.054869 (rank : 105)
Query Neighborhood Hits	108	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG1_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.084382 (rank : 84)
Query Neighborhood Hits	108	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.083681 (rank : 85)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.069375 (rank : 92)
Query Neighborhood Hits	108	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.095816 (rank : 72)
Query Neighborhood Hits	108	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.053819 (rank : 112)
Query Neighborhood Hits	108	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.054856 (rank : 106)
Query Neighborhood Hits	108	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.087839 (rank : 78)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.086902 (rank : 80)
Query Neighborhood Hits	108	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.117968 (rank : 62)
Query Neighborhood Hits	108	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG7_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.065758 (rank : 98)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.054341 (rank : 109)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG8_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.054633 (rank : 108)
Query Neighborhood Hits	108	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG9_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.081437 (rank : 86)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	11
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.080204 (rank : 88)
Query Neighborhood Hits	108	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGA_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.110644 (rank : 66)
Query Neighborhood Hits	108	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.112280 (rank : 65)
Query Neighborhood Hits	108	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.066694 (rank : 95)
Query Neighborhood Hits	108	Target Neighborhood Hits	375	Shared Neighborhood Hits	12
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.065988 (rank : 96)
Query Neighborhood Hits	108	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.065139 (rank : 99)
Query Neighborhood Hits	108	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.103780 (rank : 69)
Query Neighborhood Hits	108	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.102239 (rank : 70)
Query Neighborhood Hits	108	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.094684 (rank : 73)
Query Neighborhood Hits	108	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BCR_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.087065 (rank : 79)
Query Neighborhood Hits	108	Target Neighborhood Hits	204	Shared Neighborhood Hits	14
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CJ064_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.080971 (rank : 87)
Query Neighborhood Hits	108	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

DSPP_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.057133 (rank : 103)
Query Neighborhood Hits	108	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

ECT2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.132733 (rank : 60)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.136178 (rank : 59)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	13
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP1_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.140158 (rank : 58)
Query Neighborhood Hits	108	Target Neighborhood Hits	241	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FARP2_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.144925 (rank : 55)
Query Neighborhood Hits	108	Target Neighborhood Hits	240	Shared Neighborhood Hits	20
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.143583 (rank : 56)
Query Neighborhood Hits	108	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

GNRP_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.086454 (rank : 82)
Query Neighborhood Hits	108	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.086582 (rank : 81)
Query Neighborhood Hits	108	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

HAPIP_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.107354 (rank : 67)
Query Neighborhood Hits	108	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ITSN1_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.070350 (rank : 89)
Query Neighborhood Hits	108	Target Neighborhood Hits	1757	Shared Neighborhood Hits	31
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.070132 (rank : 90)
Query Neighborhood Hits	108	Target Neighborhood Hits	1669	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.069767 (rank : 91)
Query Neighborhood Hits	108	Target Neighborhood Hits	1173	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.068650 (rank : 93)
Query Neighborhood Hits	108	Target Neighborhood Hits	1371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LBC_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.088420 (rank : 77)
Query Neighborhood Hits	108	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

MCF2L_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.093331 (rank : 74)
Query Neighborhood Hits	108	Target Neighborhood Hits	255	Shared Neighborhood Hits	16
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.092132 (rank : 75)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

NGEF_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.105107 (rank : 68)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.102121 (rank : 71)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PKHA6_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.065026 (rank : 100)
Query Neighborhood Hits	108	Target Neighborhood Hits	556	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.062293 (rank : 101)
Query Neighborhood Hits	108	Target Neighborhood Hits	591	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHG1_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.114076 (rank : 64)
Query Neighborhood Hits	108	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.090266 (rank : 76)
Query Neighborhood Hits	108	Target Neighborhood Hits	200	Shared Neighborhood Hits	13
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PREX1_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.141380 (rank : 57)
Query Neighborhood Hits	108	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

RUFY3_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.117102 (rank : 63)
Query Neighborhood Hits	108	Target Neighborhood Hits	594	Shared Neighborhood Hits	14
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.118616 (rank : 61)
Query Neighborhood Hits	108	Target Neighborhood Hits	579	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SWP70_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.054660 (rank : 107)
Query Neighborhood Hits	108	Target Neighborhood Hits	973	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.051638 (rank : 114)
Query Neighborhood Hits	108	Target Neighborhood Hits	1097	Shared Neighborhood Hits	31
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TIAM1_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.068108 (rank : 94)
Query Neighborhood Hits	108	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.065782 (rank : 97)
Query Neighborhood Hits	108	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

VAV2_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.053964 (rank : 111)
Query Neighborhood Hits	108	Target Neighborhood Hits	456	Shared Neighborhood Hits	15
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.053997 (rank : 110)
Query Neighborhood Hits	108	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.053355 (rank : 113)
Query Neighborhood Hits	108	Target Neighborhood Hits	404	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.058268 (rank : 102)
Query Neighborhood Hits	108	Target Neighborhood Hits	452	Shared Neighborhood Hits	12
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.055816 (rank : 104)
Query Neighborhood Hits	108	Target Neighborhood Hits	430	Shared Neighborhood Hits	11
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

ZFY16_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	108	Target Neighborhood Hits	108	Shared Neighborhood Hits	108
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
NC score	0.983444 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	108	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

ZFYV9_HUMAN
NC score	0.945409 (rank : 3)	θ value	4.40161e-164 (rank : 3)
Query Neighborhood Hits	108	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY21_MOUSE
NC score	0.735518 (rank : 4)	θ value	1.09485e-13 (rank : 8)
Query Neighborhood Hits	108	Target Neighborhood Hits	72	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.727552 (rank : 5)	θ value	7.09661e-13 (rank : 10)
Query Neighborhood Hits	108	Target Neighborhood Hits	72	Shared Neighborhood Hits	55
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.681424 (rank : 6)	θ value	2.52405e-10 (rank : 29)
Query Neighborhood Hits	108	Target Neighborhood Hits	152	Shared Neighborhood Hits	54
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

PKHF2_MOUSE
NC score	0.669972 (rank : 7)	θ value	1.33837e-11 (rank : 19)
Query Neighborhood Hits	108	Target Neighborhood Hits	77	Shared Neighborhood Hits	48
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PKHF2_HUMAN
NC score	0.669434 (rank : 8)	θ value	1.33837e-11 (rank : 18)
Query Neighborhood Hits	108	Target Neighborhood Hits	75	Shared Neighborhood Hits	48
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF1_HUMAN
NC score	0.656874 (rank : 9)	θ value	2.79066e-09 (rank : 34)
Query Neighborhood Hits	108	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.652996 (rank : 10)	θ value	2.13673e-09 (rank : 33)
Query Neighborhood Hits	108	Target Neighborhood Hits	80	Shared Neighborhood Hits	50
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

FGD5_MOUSE
NC score	0.555372 (rank : 11)	θ value	2.28291e-11 (rank : 21)
Query Neighborhood Hits	108	Target Neighborhood Hits	170	Shared Neighborhood Hits	54
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FGD6_HUMAN
NC score	0.553287 (rank : 12)	θ value	1.63225e-17 (rank : 4)
Query Neighborhood Hits	108	Target Neighborhood Hits	237	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
NC score	0.547509 (rank : 13)	θ value	2.0648e-12 (rank : 11)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

ZFYV1_HUMAN
NC score	0.544803 (rank : 14)	θ value	2.61198e-07 (rank : 37)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	57
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

FGD6_MOUSE
NC score	0.544016 (rank : 15)	θ value	2.7842e-17 (rank : 5)
Query Neighborhood Hits	108	Target Neighborhood Hits	282	Shared Neighborhood Hits	52
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ZFYV1_MOUSE
NC score	0.541200 (rank : 16)	θ value	3.41135e-07 (rank : 38)
Query Neighborhood Hits	108	Target Neighborhood Hits	153	Shared Neighborhood Hits	59
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

HGS_MOUSE
NC score	0.541169 (rank : 17)	θ value	2.20605e-14 (rank : 6)
Query Neighborhood Hits	108	Target Neighborhood Hits	589	Shared Neighborhood Hits	59
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.541118 (rank : 18)	θ value	6.41864e-14 (rank : 7)
Query Neighborhood Hits	108	Target Neighborhood Hits	517	Shared Neighborhood Hits	57
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

FYV1_MOUSE
NC score	0.511156 (rank : 19)	θ value	1.02475e-11 (rank : 16)
Query Neighborhood Hits	108	Target Neighborhood Hits	191	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.511108 (rank : 20)	θ value	1.02475e-11 (rank : 15)
Query Neighborhood Hits	108	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FGD2_MOUSE
NC score	0.493094 (rank : 21)	θ value	3.89403e-11 (rank : 22)
Query Neighborhood Hits	108	Target Neighborhood Hits	163	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD2_HUMAN
NC score	0.492522 (rank : 22)	θ value	5.08577e-11 (rank : 23)
Query Neighborhood Hits	108	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

RBNS5_HUMAN
NC score	0.475471 (rank : 23)	θ value	4.92598e-06 (rank : 41)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

FGD4_HUMAN
NC score	0.473666 (rank : 24)	θ value	7.84624e-12 (rank : 13)
Query Neighborhood Hits	108	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

RBNS5_MOUSE
NC score	0.472220 (rank : 25)	θ value	4.92598e-06 (rank : 42)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	52
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

FGD4_MOUSE
NC score	0.469770 (rank : 26)	θ value	2.28291e-11 (rank : 20)
Query Neighborhood Hits	108	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD1_MOUSE
NC score	0.469357 (rank : 27)	θ value	4.16044e-13 (rank : 9)
Query Neighborhood Hits	108	Target Neighborhood Hits	387	Shared Neighborhood Hits	52
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.468496 (rank : 28)	θ value	2.69671e-12 (rank : 12)
Query Neighborhood Hits	108	Target Neighborhood Hits	367	Shared Neighborhood Hits	51
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZFY19_HUMAN
NC score	0.460419 (rank : 29)	θ value	0.000461057 (rank : 48)
Query Neighborhood Hits	108	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
NC score	0.452300 (rank : 30)	θ value	0.00390308 (rank : 50)
Query Neighborhood Hits	108	Target Neighborhood Hits	143	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FGD3_HUMAN
NC score	0.429793 (rank : 31)	θ value	3.77169e-06 (rank : 40)
Query Neighborhood Hits	108	Target Neighborhood Hits	249	Shared Neighborhood Hits	54
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

ZFY27_MOUSE
NC score	0.407023 (rank : 32)	θ value	4.1701e-05 (rank : 46)
Query Neighborhood Hits	108	Target Neighborhood Hits	53	Shared Neighborhood Hits	44
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.399693 (rank : 33)	θ value	0.000602161 (rank : 49)
Query Neighborhood Hits	108	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

MTMR3_HUMAN
NC score	0.395152 (rank : 34)	θ value	1.33837e-11 (rank : 17)
Query Neighborhood Hits	108	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

FGD3_MOUSE
NC score	0.390614 (rank : 35)	θ value	9.29e-05 (rank : 47)
Query Neighborhood Hits	108	Target Neighborhood Hits	257	Shared Neighborhood Hits	55
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

RUFY1_MOUSE
NC score	0.382899 (rank : 36)	θ value	8.67504e-11 (rank : 24)
Query Neighborhood Hits	108	Target Neighborhood Hits	765	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

WDFY3_MOUSE
NC score	0.378526 (rank : 37)	θ value	1.25267e-09 (rank : 31)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RUFY2_MOUSE
NC score	0.377539 (rank : 38)	θ value	2.52405e-10 (rank : 28)
Query Neighborhood Hits	108	Target Neighborhood Hits	820	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

WDFY3_HUMAN
NC score	0.376883 (rank : 39)	θ value	1.63604e-09 (rank : 32)
Query Neighborhood Hits	108	Target Neighborhood Hits	348	Shared Neighborhood Hits	55
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

RUFY1_HUMAN
NC score	0.374885 (rank : 40)	θ value	1.9326e-10 (rank : 27)
Query Neighborhood Hits	108	Target Neighborhood Hits	848	Shared Neighborhood Hits	59
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY1_HUMAN
NC score	0.372601 (rank : 41)	θ value	1.43324e-05 (rank : 45)
Query Neighborhood Hits	108	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_MOUSE
NC score	0.366158 (rank : 42)	θ value	1.09739e-05 (rank : 44)
Query Neighborhood Hits	108	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.363340 (rank : 43)	θ value	1.09739e-05 (rank : 43)
Query Neighborhood Hits	108	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

RUFY2_HUMAN
NC score	0.301276 (rank : 44)	θ value	1.133e-10 (rank : 25)
Query Neighborhood Hits	108	Target Neighborhood Hits	1208	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

FYCO1_HUMAN
NC score	0.273590 (rank : 45)	θ value	1.02475e-11 (rank : 14)
Query Neighborhood Hits	108	Target Neighborhood Hits	1149	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ANFY1_MOUSE
NC score	0.256324 (rank : 46)	θ value	2.36244e-08 (rank : 36)
Query Neighborhood Hits	108	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

FYCO1_MOUSE
NC score	0.252759 (rank : 47)	θ value	1.38499e-08 (rank : 35)
Query Neighborhood Hits	108	Target Neighborhood Hits	1059	Shared Neighborhood Hits	59
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ANFY1_HUMAN
NC score	0.251186 (rank : 48)	θ value	4.45536e-07 (rank : 39)
Query Neighborhood Hits	108	Target Neighborhood Hits	480	Shared Neighborhood Hits	53
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

EEA1_MOUSE
NC score	0.229345 (rank : 49)	θ value	1.9326e-10 (rank : 26)
Query Neighborhood Hits	108	Target Neighborhood Hits	1637	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EEA1_HUMAN
NC score	0.211387 (rank : 50)	θ value	5.62301e-10 (rank : 30)
Query Neighborhood Hits	108	Target Neighborhood Hits	1796	Shared Neighborhood Hits	67
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

RFFL_MOUSE
NC score	0.189172 (rank : 51)	θ value	0.0113563 (rank : 51)
Query Neighborhood Hits	108	Target Neighborhood Hits	145	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_MOUSE
NC score	0.177403 (rank : 52)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	108	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.176997 (rank : 53)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	108	Target Neighborhood Hits	153	Shared Neighborhood Hits	33
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_HUMAN
NC score	0.175987 (rank : 54)	θ value	0.0431538 (rank : 52)
Query Neighborhood Hits	108	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

FARP2_HUMAN
NC score	0.144925 (rank : 55)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	108	Target Neighborhood Hits	240	Shared Neighborhood Hits	20
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_MOUSE
NC score	0.143583 (rank : 56)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	108	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

PREX1_HUMAN
NC score	0.141380 (rank : 57)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	108	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FARP1_HUMAN
NC score	0.140158 (rank : 58)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	108	Target Neighborhood Hits	241	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

ECT2_MOUSE
NC score	0.136178 (rank : 59)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	13
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.132733 (rank : 60)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

RUFY3_MOUSE
NC score	0.118616 (rank : 61)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	108	Target Neighborhood Hits	579	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

ARHG5_HUMAN
NC score	0.117968 (rank : 62)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	108	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

RUFY3_HUMAN
NC score	0.117102 (rank : 63)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	108	Target Neighborhood Hits	594	Shared Neighborhood Hits	14
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

PKHG1_HUMAN
NC score	0.114076 (rank : 64)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	108	Target Neighborhood Hits	174	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHGA_MOUSE
NC score	0.112280 (rank : 65)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	108	Target Neighborhood Hits	125	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_HUMAN
NC score	0.110644 (rank : 66)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	108	Target Neighborhood Hits	187	Shared Neighborhood Hits	12
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

HAPIP_HUMAN
NC score	0.107354 (rank : 67)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	108	Target Neighborhood Hits	350	Shared Neighborhood Hits	21
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

NGEF_HUMAN
NC score	0.105107 (rank : 68)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGF_HUMAN
NC score	0.103780 (rank : 69)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	108	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
NC score	0.102239 (rank : 70)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	108	Target Neighborhood Hits	129	Shared Neighborhood Hits	12
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_MOUSE
NC score	0.102121 (rank : 71)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG2_MOUSE
NC score	0.095816 (rank : 72)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	108	Target Neighborhood Hits	120	Shared Neighborhood Hits	12
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGG_MOUSE
NC score	0.094684 (rank : 73)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	108	Target Neighborhood Hits	152	Shared Neighborhood Hits	12
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
NC score	0.093331 (rank : 74)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	108	Target Neighborhood Hits	255	Shared Neighborhood Hits	16
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
NC score	0.092132 (rank : 75)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	13
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PKHG4_HUMAN
NC score	0.090266 (rank : 76)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	108	Target Neighborhood Hits	200	Shared Neighborhood Hits	13
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

LBC_HUMAN
NC score	0.088420 (rank : 77)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	108	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHG4_HUMAN
NC score	0.087839 (rank : 78)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	108	Target Neighborhood Hits	242	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BCR_HUMAN
NC score	0.087065 (rank : 79)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	108	Target Neighborhood Hits	204	Shared Neighborhood Hits	14
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG4_MOUSE
NC score	0.086902 (rank : 80)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	108	Target Neighborhood Hits	185	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

GNRP_MOUSE
NC score	0.086582 (rank : 81)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	108	Target Neighborhood Hits	191	Shared Neighborhood Hits	13
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GNRP_HUMAN
NC score	0.086454 (rank : 82)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	108	Target Neighborhood Hits	239	Shared Neighborhood Hits	15
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ABR_HUMAN
NC score	0.084993 (rank : 83)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	108	Target Neighborhood Hits	166	Shared Neighborhood Hits	12
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHG1_HUMAN
NC score	0.084382 (rank : 84)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	108	Target Neighborhood Hits	176	Shared Neighborhood Hits	15
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
NC score	0.083681 (rank : 85)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	108	Target Neighborhood Hits	266	Shared Neighborhood Hits	15
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG9_HUMAN
NC score	0.081437 (rank : 86)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	108	Target Neighborhood Hits	235	Shared Neighborhood Hits	11
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

CJ064_HUMAN
NC score	0.080971 (rank : 87)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	108	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZS81, Q8N4A3	Gene names	C10orf64
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf64.

ARHG9_MOUSE
NC score	0.080204 (rank : 88)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	108	Target Neighborhood Hits	234	Shared Neighborhood Hits	11
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ITSN1_HUMAN
NC score	0.070350 (rank : 89)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	108	Target Neighborhood Hits	1757	Shared Neighborhood Hits	31
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.070132 (rank : 90)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	108	Target Neighborhood Hits	1669	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
NC score	0.069767 (rank : 91)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	108	Target Neighborhood Hits	1173	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ARHG2_HUMAN
NC score	0.069375 (rank : 92)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	108	Target Neighborhood Hits	142	Shared Neighborhood Hits	10
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ITSN2_MOUSE
NC score	0.068650 (rank : 93)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	108	Target Neighborhood Hits	1371	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

TIAM1_HUMAN
NC score	0.068108 (rank : 94)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	108	Target Neighborhood Hits	225	Shared Neighborhood Hits	14
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHGB_HUMAN
NC score	0.066694 (rank : 95)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	108	Target Neighborhood Hits	375	Shared Neighborhood Hits	12
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
NC score	0.065988 (rank : 96)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	108	Target Neighborhood Hits	351	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

TIAM1_MOUSE
NC score	0.065782 (rank : 97)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	108	Target Neighborhood Hits	205	Shared Neighborhood Hits	14
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_HUMAN
NC score	0.065758 (rank : 98)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	15
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHGC_MOUSE
NC score	0.065139 (rank : 99)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	108	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

PKHA6_HUMAN
NC score	0.065026 (rank : 100)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	108	Target Neighborhood Hits	556	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.062293 (rank : 101)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	108	Target Neighborhood Hits	591	Shared Neighborhood Hits	18
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

VAV_HUMAN
NC score	0.058268 (rank : 102)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	108	Target Neighborhood Hits	452	Shared Neighborhood Hits	12
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

DSPP_HUMAN
NC score	0.057133 (rank : 103)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	108	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

VAV_MOUSE
NC score	0.055816 (rank : 104)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	108	Target Neighborhood Hits	430	Shared Neighborhood Hits	11
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ALS2_MOUSE
NC score	0.054869 (rank : 105)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	108	Target Neighborhood Hits	111	Shared Neighborhood Hits	13
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ARHG3_MOUSE
NC score	0.054856 (rank : 106)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	108	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

SWP70_HUMAN
NC score	0.054660 (rank : 107)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	108	Target Neighborhood Hits	973	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ARHG8_HUMAN
NC score	0.054633 (rank : 108)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	108	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG7_MOUSE
NC score	0.054341 (rank : 109)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	108	Target Neighborhood Hits	396	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV3_HUMAN
NC score	0.053997 (rank : 110)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	108	Target Neighborhood Hits	398	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.053964 (rank : 111)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	108	Target Neighborhood Hits	456	Shared Neighborhood Hits	15
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG3_HUMAN
NC score	0.053819 (rank : 112)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	108	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

VAV3_MOUSE
NC score	0.053355 (rank : 113)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	108	Target Neighborhood Hits	404	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SWP70_MOUSE
NC score	0.051638 (rank : 114)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	108	Target Neighborhood Hits	1097	Shared Neighborhood Hits	31
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

LYST_MOUSE
NC score	0.049181 (rank : 115)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	108	Target Neighborhood Hits	286	Shared Neighborhood Hits	7
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

CCD39_HUMAN
NC score	0.039935 (rank : 116)	θ value	2.36792 (rank : 64)
Query Neighborhood Hits	108	Target Neighborhood Hits	868	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

HOOK2_HUMAN
NC score	0.036296 (rank : 117)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	108	Target Neighborhood Hits	714	Shared Neighborhood Hits	13
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

TEX2_HUMAN
NC score	0.035840 (rank : 118)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	108	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IWB9, Q6AHZ5, Q8N3L0, Q9C0C5	Gene names	TEX2, KIAA1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

CT2NL_MOUSE
NC score	0.034979 (rank : 119)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	108	Target Neighborhood Hits	902	Shared Neighborhood Hits	17
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

TTC17_HUMAN
NC score	0.034371 (rank : 120)	θ value	0.813845 (rank : 62)
Query Neighborhood Hits	108	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q96AE7	Gene names	TTC17
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 17 (TPR repeat protein 17).

TACC2_HUMAN
NC score	0.031592 (rank : 121)	θ value	0.62314 (rank : 60)
Query Neighborhood Hits	108	Target Neighborhood Hits	856	Shared Neighborhood Hits	16
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

MIRO2_MOUSE
NC score	0.026073 (rank : 122)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	108	Target Neighborhood Hits	228	Shared Neighborhood Hits	4
SwissProt Accessions	Q8JZN7	Gene names	Rhot2, Arht2
Domain Architecture	No domain graphic available
Description	Mitochondrial Rho GTPase 2 (EC 3.6.5.-) (MIRO-2) (Ras homolog gene family member T2).

TEX2_MOUSE
NC score	0.023908 (rank : 123)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	108	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZPJ0	Gene names	Tex2, Kiaa1738
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 2 protein.

KIF4A_HUMAN
NC score	0.023440 (rank : 124)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	108	Target Neighborhood Hits	1159	Shared Neighborhood Hits	17
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

ACINU_HUMAN
NC score	0.022625 (rank : 125)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	108	Target Neighborhood Hits	828	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

MLL2_HUMAN
NC score	0.022624 (rank : 126)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	108	Target Neighborhood Hits	1788	Shared Neighborhood Hits	28
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ZN292_HUMAN
NC score	0.018469 (rank : 127)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	108	Target Neighborhood Hits	918	Shared Neighborhood Hits	13
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

GP137_MOUSE
NC score	0.018355 (rank : 128)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	108	Target Neighborhood Hits	102	Shared Neighborhood Hits	3
SwissProt Accessions	Q60865, Q60758, Q61620	Gene names	M11s1, Gpiap, Gpiap1, Gpip137
Domain Architecture	No domain graphic available
Description	GPI-anchored protein p137 (p137GPI).

ZFAN3_MOUSE
NC score	0.017993 (rank : 129)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	108	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

TDRKH_HUMAN
NC score	0.015451 (rank : 130)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	108	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2W6, Q8N582, Q9NYV5	Gene names	TDRKH, TDRD2
Domain Architecture
Description	Tudor and KH domain-containing protein.

FSTL5_MOUSE
NC score	0.015021 (rank : 131)	θ value	0.62314 (rank : 59)
Query Neighborhood Hits	108	Target Neighborhood Hits	355	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

NU214_HUMAN
NC score	0.014804 (rank : 132)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	108	Target Neighborhood Hits	657	Shared Neighborhood Hits	10
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

NIPA_HUMAN
NC score	0.014598 (rank : 133)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	108	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WB0, Q75MF3, Q75MF4, Q8N330, Q96F75, Q9HA34, Q9NVX4, Q9P0R0	Gene names	ZC3HC1, NIPA
Domain Architecture	No domain graphic available
Description	Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1).

ANK3_HUMAN
NC score	0.014333 (rank : 134)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	108	Target Neighborhood Hits	853	Shared Neighborhood Hits	13
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

MINT_MOUSE
NC score	0.012803 (rank : 135)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	108	Target Neighborhood Hits	1514	Shared Neighborhood Hits	14
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

FSTL5_HUMAN
NC score	0.011414 (rank : 136)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

EST1A_HUMAN
NC score	0.011032 (rank : 137)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	108	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q86US8, O94837, Q86VH6, Q9UF60	Gene names	EST1A, C17orf31, KIAA0732
Domain Architecture
Description	Telomerase-binding protein EST1A (Ever shorter telomeres 1A) (Telomerase subunit EST1A) (EST1-like protein A) (hSmg5/7a).

COA2_HUMAN
NC score	0.010713 (rank : 138)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	108	Target Neighborhood Hits	184	Shared Neighborhood Hits	5
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

UBP1_HUMAN
NC score	0.009006 (rank : 139)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	108	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	O94782, Q9UFR0, Q9UNJ3	Gene names	USP1
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.1.2.15) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) (Deubiquitinating enzyme 1) (hUBP).

IF4G1_HUMAN
NC score	0.008878 (rank : 140)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	108	Target Neighborhood Hits	347	Shared Neighborhood Hits	6
SwissProt Accessions	Q04637, O43177, O95066, Q5HYG0, Q6ZN21, Q8N102	Gene names	EIF4G1, EIF4G, EIF4GI
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1) (p220).

RIMB2_MOUSE
NC score	0.007977 (rank : 141)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	108	Target Neighborhood Hits	246	Shared Neighborhood Hits	4
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SSH2_MOUSE
NC score	0.007376 (rank : 142)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	108	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q5SW75, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78	Gene names	Ssh2, Kiaa1725, Ssh2l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 2 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-2L) (mSSH-2L).

RINI_MOUSE
NC score	0.006674 (rank : 143)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	108	Target Neighborhood Hits	87	Shared Neighborhood Hits	2
SwissProt Accessions	Q91VI7, Q924P4	Gene names	Rnh1, Rnh
Domain Architecture	No domain graphic available
Description	Ribonuclease inhibitor (Ribonuclease/angiogenin inhibitor 1).

RNF14_HUMAN
NC score	0.006119 (rank : 144)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	108	Target Neighborhood Hits	70	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBS8, O94793, Q6IBV0	Gene names	RNF14, ARA54
Domain Architecture
Description	RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30).

UBR1_MOUSE
NC score	0.006114 (rank : 145)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	108	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	O70481, Q5BKR8, Q792M3, Q8BN40, Q8C5K3	Gene names	Ubr1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-1 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3- alpha-I).

SP2_HUMAN
NC score	0.006020 (rank : 146)	θ value	0.813845 (rank : 61)
Query Neighborhood Hits	108	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q02086	Gene names	SP2, KIAA0048
Domain Architecture
Description	Transcription factor Sp2.

TLR7_HUMAN
NC score	0.005463 (rank : 147)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	108	Target Neighborhood Hits	312	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYK1, Q9NR98	Gene names	TLR7
Domain Architecture
Description	Toll-like receptor 7 precursor.

OVOL1_MOUSE
NC score	0.004882 (rank : 148)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	108	Target Neighborhood Hits	716	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTJ2, Q545S2	Gene names	Ovol1
Domain Architecture	No domain graphic available
Description	Putative transcription factor Ovo-like 1 (mOvo1) (mOvo1a).

ZEP1_HUMAN
NC score	0.004263 (rank : 149)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	108	Target Neighborhood Hits	1036	Shared Neighborhood Hits	19
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

OVOL1_HUMAN
NC score	0.003910 (rank : 150)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	108	Target Neighborhood Hits	729	Shared Neighborhood Hits	18
SwissProt Accessions	O14753, Q6PCB1	Gene names	OVOL1
Domain Architecture	No domain graphic available
Description	Putative transcription factor Ovo-like 1 (hOvo1).

CXA10_HUMAN
NC score	0.003875 (rank : 151)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	108	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	P57773, Q96KG0	Gene names	GJA10
Domain Architecture
Description	Gap junction alpha-10 protein (Connexin-59) (Cx59) (Connexin-58) (Cx58).

MAZ_HUMAN
NC score	0.001448 (rank : 152)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	108	Target Neighborhood Hits	757	Shared Neighborhood Hits	16
SwissProt Accessions	P56270, Q15703, Q99443	Gene names	MAZ
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1) (ZF87) (ZIF87).

MAZ_MOUSE
NC score	0.001393 (rank : 153)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	108	Target Neighborhood Hits	745	Shared Neighborhood Hits	16
SwissProt Accessions	P56671, Q9R1W0	Gene names	Maz
Domain Architecture	No domain graphic available
Description	Myc-associated zinc finger protein (MAZI) (Purine-binding transcription factor) (Pur-1).

RAB6A_MOUSE
NC score	0.001209 (rank : 154)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	108	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35279, Q542M6, Q8R2Z7, Q8VEE5, Q9JJD4	Gene names	Rab6a, Rab6
Domain Architecture
Description	Ras-related protein Rab-6A (Rab-6).

RAB6A_HUMAN
NC score	0.001208 (rank : 155)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	108	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P20340, Q9UBE4	Gene names	RAB6A, RAB6
Domain Architecture
Description	Ras-related protein Rab-6A (Rab-6).

VEZF1_HUMAN
NC score	0.001191 (rank : 156)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	108	Target Neighborhood Hits	744	Shared Neighborhood Hits	16
SwissProt Accessions	Q14119	Gene names	VEZF1, DB1, ZNF161
Domain Architecture	No domain graphic available
Description	Vascular endothelial zinc finger 1 (Zinc finger protein 161) (Putative transcription factor DB1).

ZN408_HUMAN
NC score	0.000778 (rank : 157)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	108	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q9H9D4	Gene names	ZNF408, PFM14, PRDM17
Domain Architecture	No domain graphic available
Description	Zinc finger protein 408 (PR-domain zinc finger protein 17).

PTPRZ_HUMAN
NC score	0.000726 (rank : 158)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	108	Target Neighborhood Hits	255	Shared Neighborhood Hits	2
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PCDB1_HUMAN
NC score	0.000391 (rank : 159)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	108	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y5F3	Gene names	PCDHB1
Domain Architecture
Description	Protocadherin beta 1 precursor (PCDH-beta1).

ZN230_HUMAN
NC score	0.000145 (rank : 160)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	108	Target Neighborhood Hits	750	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UIE0, O15322, Q9P1U6	Gene names	ZNF230, FDZF2
Domain Architecture
Description	Zinc finger protein 230 (Zinc finger protein FDZF2).

ZN699_HUMAN
NC score	0.000005 (rank : 161)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	108	Target Neighborhood Hits	773	Shared Neighborhood Hits	24
SwissProt Accessions	Q32M78, Q8N9A1	Gene names	ZNF699
Domain Architecture	No domain graphic available
Description	Zinc finger protein 699 (Hangover homolog).

ZFY1_MOUSE
NC score	-0.000112 (rank : 162)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	108	Target Neighborhood Hits	790	Shared Neighborhood Hits	17
SwissProt Accessions	P10925	Gene names	Zfy1, Zfy-1
Domain Architecture
Description	Zinc finger Y-chromosomal protein 1.

FATH_HUMAN
NC score	-0.000813 (rank : 163)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	108	Target Neighborhood Hits	570	Shared Neighborhood Hits	4
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

ZF64A_HUMAN
NC score	-0.000914 (rank : 164)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	108	Target Neighborhood Hits	737	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPA5, Q9NTS7, Q9NVH4	Gene names	ZFP64, ZNF338
Domain Architecture	No domain graphic available
Description	Zinc finger protein 64, isoforms 1 and 2 (Zinc finger protein 338).

ZF64B_HUMAN
NC score	-0.001121 (rank : 165)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	108	Target Neighborhood Hits	740	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NTW7, Q8WU98, Q9H9P1	Gene names	ZFP64, ZNF338
Domain Architecture	No domain graphic available
Description	Zinc finger protein 64, isoforms 3 and 4 (Zinc finger protein 338).

LSHR_HUMAN
NC score	-0.001153 (rank : 166)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	108	Target Neighborhood Hits	731	Shared Neighborhood Hits	3
SwissProt Accessions	P22888, Q14751, Q15996, Q9UEW9	Gene names	LHCGR, LCGR, LGR2, LHRHR
Domain Architecture
Description	Lutropin-choriogonadotropic hormone receptor precursor (LH/CG-R) (LSH- R) (Luteinizing hormone receptor) (LHR).

TITIN_HUMAN
NC score	-0.002055 (rank : 167)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	108	Target Neighborhood Hits	2923	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

NEK11_MOUSE
NC score	-0.003932 (rank : 168)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	108	Target Neighborhood Hits	875	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).