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Network neighborhood for query Sequence : HELC1_HUMAN

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HELC1_HUMAN
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HELC1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

U520_HUMAN
θ value	0 (rank : 2)	NC score	0.952338 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

SK2L2_MOUSE
θ value	8.08199e-25 (rank : 3)	NC score	0.554084 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SK2L2_HUMAN
θ value	2.35151e-24 (rank : 4)	NC score	0.552094 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SKIV2_HUMAN
θ value	2.87452e-22 (rank : 5)	NC score	0.569619 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

SEC63_MOUSE
θ value	1.99992e-07 (rank : 6)	NC score	0.201015 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	601	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SEC63_HUMAN
θ value	2.61198e-07 (rank : 7)	NC score	0.201722 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

DDX58_MOUSE
θ value	4.92598e-06 (rank : 8)	NC score	0.246465 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX52_HUMAN
θ value	8.40245e-06 (rank : 9)	NC score	0.164665 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
θ value	5.44631e-05 (rank : 10)	NC score	0.164789 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX58_HUMAN
θ value	9.29e-05 (rank : 11)	NC score	0.240831 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	31
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

FANCM_MOUSE
θ value	9.29e-05 (rank : 12)	NC score	0.235411 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

FANCM_HUMAN
θ value	0.000158464 (rank : 13)	NC score	0.227583 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	210	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

DDX6_HUMAN
θ value	0.00035302 (rank : 14)	NC score	0.127569 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	39
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	0.00035302 (rank : 15)	NC score	0.127560 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

RECQ4_MOUSE
θ value	0.00102713 (rank : 16)	NC score	0.198850 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

LGP2_MOUSE
θ value	0.00134147 (rank : 17)	NC score	0.223086 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	86	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

DDX4_HUMAN
θ value	0.00509761 (rank : 18)	NC score	0.134283 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	123	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

RECQ4_HUMAN
θ value	0.00509761 (rank : 19)	NC score	0.193692 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

DICER_MOUSE
θ value	0.00665767 (rank : 20)	NC score	0.201965 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

WRN_MOUSE
θ value	0.00665767 (rank : 21)	NC score	0.166426 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	295	Shared Neighborhood Hits	37
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

DDX46_HUMAN
θ value	0.00869519 (rank : 22)	NC score	0.144729 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	357	Shared Neighborhood Hits	44
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	0.00869519 (rank : 23)	NC score	0.144351 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	358	Shared Neighborhood Hits	43
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX4_MOUSE
θ value	0.00869519 (rank : 24)	NC score	0.133252 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

WRN_HUMAN
θ value	0.00869519 (rank : 25)	NC score	0.178648 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

IFIH1_MOUSE
θ value	0.0113563 (rank : 26)	NC score	0.212184 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

RECQ5_HUMAN
θ value	0.0193708 (rank : 27)	NC score	0.169541 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

LGP2_HUMAN
θ value	0.0252991 (rank : 28)	NC score	0.206601 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DICER_HUMAN
θ value	0.0563607 (rank : 29)	NC score	0.191050 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DDX51_HUMAN
θ value	0.163984 (rank : 30)	NC score	0.133322 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

IFIH1_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.197904 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

DDX31_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.119558 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

WDR63_HUMAN
θ value	0.47712 (rank : 33)	NC score	0.050650 (rank : 95)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWG1, Q96L72, Q96NU4	Gene names	WDR63
Domain Architecture	No domain graphic available
Description	WD repeat protein 63 (Testis development protein NYD-SP29).

DDX21_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.111497 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	308	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX49_HUMAN
θ value	0.813845 (rank : 35)	NC score	0.113755 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	223	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

KLD8A_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.020489 (rank : 99)
Query Neighborhood Hits	71	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q91XA8	Gene names	Klhdc8a
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 8A.

BRWD1_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.012005 (rank : 113)
Query Neighborhood Hits	71	Target Neighborhood Hits	448	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

EXOC7_HUMAN
θ value	1.81305 (rank : 38)	NC score	0.039543 (rank : 96)
Query Neighborhood Hits	71	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPT5, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32	Gene names	EXOC7, EXO70, KIAA1067
Domain Architecture
Description	Exocyst complex component 7 (Exocyst complex component Exo70).

DDX28_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.108618 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

EVA1_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.024460 (rank : 98)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O60487	Gene names	EVA1, EVA
Domain Architecture
Description	Epithelial V-like antigen 1 precursor.

EXOC7_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.038119 (rank : 97)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	O35250, Q8K121	Gene names	Exoc7, Exo70
Domain Architecture
Description	Exocyst complex component 7 (Exocyst complex component Exo70).

BTBD5_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.006438 (rank : 119)
Query Neighborhood Hits	71	Target Neighborhood Hits	190	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXS3	Gene names	BTBD5
Domain Architecture
Description	BTB/POZ domain-containing protein 5.

DDX3Y_MOUSE
θ value	3.0926 (rank : 43)	NC score	0.106740 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX49_MOUSE
θ value	3.0926 (rank : 44)	NC score	0.112719 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

GRIA2_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.016326 (rank : 101)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	P42262, Q96FP6	Gene names	GRIA2, GLUR2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA2_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.016344 (rank : 100)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3	Gene names	Gria2, Glur2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

MYO6_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.007502 (rank : 117)
Query Neighborhood Hits	71	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

RECQ1_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.150190 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	36
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DDX43_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.123078 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX51_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.133816 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX56_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.090924 (rank : 76)
Query Neighborhood Hits	71	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

GRIA1_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.015096 (rank : 104)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P42261	Gene names	GRIA1, GLUH1, GLUR1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

JIP3_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.012449 (rank : 111)
Query Neighborhood Hits	71	Target Neighborhood Hits	1039	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

JIP3_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.013605 (rank : 108)
Query Neighborhood Hits	71	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

P5CR1_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.015185 (rank : 103)
Query Neighborhood Hits	71	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P32322, Q6FHI4, Q96DI6	Gene names	PYCR1
Domain Architecture
Description	Pyrroline-5-carboxylate reductase 1 (EC 1.5.1.2) (P5CR 1) (P5C reductase 1).

PLCB4_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.006990 (rank : 118)
Query Neighborhood Hits	71	Target Neighborhood Hits	658	Shared Neighborhood Hits	7
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

TDRD1_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.015224 (rank : 102)
Query Neighborhood Hits	71	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXT4, Q9H7B3	Gene names	TDRD1
Domain Architecture
Description	Tudor domain-containing protein 1.

ZFYV9_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.012024 (rank : 112)
Query Neighborhood Hits	71	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZN545_HUMAN
θ value	5.27518 (rank : 59)	NC score	-0.001785 (rank : 122)
Query Neighborhood Hits	71	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N141, Q8NC63, Q8TF53	Gene names	ZNF545, KIAA1948
Domain Architecture	No domain graphic available
Description	Zinc finger protein 545.

DDX41_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.106850 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.106759 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

GRIA1_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.014509 (rank : 105)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	P23818	Gene names	Gria1, Glur1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

IWS1_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.012810 (rank : 110)
Query Neighborhood Hits	71	Target Neighborhood Hits	1241	Shared Neighborhood Hits	12
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LMBL2_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.014464 (rank : 107)
Query Neighborhood Hits	71	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q969R5, Q8TEN1, Q96SC4, Q9BQI2, Q9UGS4	Gene names	L3MBTL2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

LMBL2_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.014502 (rank : 106)
Query Neighborhood Hits	71	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P59178	Gene names	L3mbtl2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

MSH4_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.010886 (rank : 114)
Query Neighborhood Hits	71	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MT2, Q920J1	Gene names	Msh4
Domain Architecture
Description	MutS protein homolog 4 (mMsh4).

MYO5C_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.005106 (rank : 120)
Query Neighborhood Hits	71	Target Neighborhood Hits	1206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

ATM_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.007852 (rank : 116)
Query Neighborhood Hits	71	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

CCNB3_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.007892 (rank : 115)
Query Neighborhood Hits	71	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ERAL_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.012923 (rank : 109)
Query Neighborhood Hits	71	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZU4, Q6NV78, Q925U1	Gene names	Eral1
Domain Architecture	No domain graphic available
Description	GTP-binding protein era homolog (ERA-W) (Conserved ERA-like GTPase) (CEGA).

GLTL2_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.003896 (rank : 121)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2N8	Gene names	Galntl2
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase-like protein 2 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase-like protein 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase- like protein 2) (Polypeptide GalNAc transferase-like protein 2) (GalNAc-T-like protein 2) (pp-GaNTase-like protein 2).

BLM_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.111121 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.104751 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	108	Shared Neighborhood Hits	28
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

DD19A_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.085527 (rank : 90)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.085992 (rank : 88)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.085723 (rank : 89)
Query Neighborhood Hits	71	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX10_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.102739 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	210	Shared Neighborhood Hits	34
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.088628 (rank : 84)
Query Neighborhood Hits	71	Target Neighborhood Hits	233	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX17_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.104187 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.104211 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	36
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX18_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.089994 (rank : 79)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.100920 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.082752 (rank : 94)
Query Neighborhood Hits	71	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.083228 (rank : 93)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX20_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.084259 (rank : 92)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.084360 (rank : 91)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX21_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.103215 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	350	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX23_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.099011 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	486	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX24_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.089487 (rank : 82)
Query Neighborhood Hits	71	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.088807 (rank : 83)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX25_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.089713 (rank : 81)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.089932 (rank : 80)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX27_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.100932 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	197	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.100098 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	174	Shared Neighborhood Hits	36
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX28_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.090149 (rank : 78)
Query Neighborhood Hits	71	Target Neighborhood Hits	103	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX39_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.091722 (rank : 75)
Query Neighborhood Hits	71	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.090920 (rank : 77)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX3X_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.102001 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	36
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.102239 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.101826 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	36
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX47_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.103098 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.102909 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX48_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.097975 (rank : 73)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.097925 (rank : 74)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX50_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.104133 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.103831 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX53_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.098551 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX54_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.106758 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX54_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.106175 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX55_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.106870 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.105702 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX56_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.086461 (rank : 87)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX5_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.102582 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.102546 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

IF4A1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.098330 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.098330 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.097998 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.097998 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

PL10_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.101106 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

RECQ1_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.135924 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

UAP56_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.088422 (rank : 86)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.088430 (rank : 85)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

Hits sorted by NC score

HELC1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

U520_HUMAN
NC score	0.952338 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	37
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

SKIV2_HUMAN
NC score	0.569619 (rank : 3)	θ value	2.87452e-22 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

SK2L2_MOUSE
NC score	0.554084 (rank : 4)	θ value	8.08199e-25 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SK2L2_HUMAN
NC score	0.552094 (rank : 5)	θ value	2.35151e-24 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

DDX58_MOUSE
NC score	0.246465 (rank : 6)	θ value	4.92598e-06 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
NC score	0.240831 (rank : 7)	θ value	9.29e-05 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	31
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

FANCM_MOUSE
NC score	0.235411 (rank : 8)	θ value	9.29e-05 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

FANCM_HUMAN
NC score	0.227583 (rank : 9)	θ value	0.000158464 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	210	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

LGP2_MOUSE
NC score	0.223086 (rank : 10)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	86	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_MOUSE
NC score	0.212184 (rank : 11)	θ value	0.0113563 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
NC score	0.206601 (rank : 12)	θ value	0.0252991 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DICER_MOUSE
NC score	0.201965 (rank : 13)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

SEC63_HUMAN
NC score	0.201722 (rank : 14)	θ value	2.61198e-07 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

SEC63_MOUSE
NC score	0.201015 (rank : 15)	θ value	1.99992e-07 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	601	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

RECQ4_MOUSE
NC score	0.198850 (rank : 16)	θ value	0.00102713 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

IFIH1_HUMAN
NC score	0.197904 (rank : 17)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

RECQ4_HUMAN
NC score	0.193692 (rank : 18)	θ value	0.00509761 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

DICER_HUMAN
NC score	0.191050 (rank : 19)	θ value	0.0563607 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

WRN_HUMAN
NC score	0.178648 (rank : 20)	θ value	0.00869519 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	35
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ5_HUMAN
NC score	0.169541 (rank : 21)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	390	Shared Neighborhood Hits	31
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_MOUSE
NC score	0.166426 (rank : 22)	θ value	0.00665767 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	295	Shared Neighborhood Hits	37
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

DDX52_MOUSE
NC score	0.164789 (rank : 23)	θ value	5.44631e-05 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_HUMAN
NC score	0.164665 (rank : 24)	θ value	8.40245e-06 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

RECQ1_HUMAN
NC score	0.150190 (rank : 25)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	36
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DDX46_HUMAN
NC score	0.144729 (rank : 26)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	357	Shared Neighborhood Hits	44
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.144351 (rank : 27)	θ value	0.00869519 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	358	Shared Neighborhood Hits	43
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

RECQ1_MOUSE
NC score	0.135924 (rank : 28)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	71	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DDX4_HUMAN
NC score	0.134283 (rank : 29)	θ value	0.00509761 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	123	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX51_MOUSE
NC score	0.133816 (rank : 30)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX51_HUMAN
NC score	0.133322 (rank : 31)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX4_MOUSE
NC score	0.133252 (rank : 32)	θ value	0.00869519 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX6_HUMAN
NC score	0.127569 (rank : 33)	θ value	0.00035302 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	39
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.127560 (rank : 34)	θ value	0.00035302 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	39
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX43_HUMAN
NC score	0.123078 (rank : 35)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX31_HUMAN
NC score	0.119558 (rank : 36)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX49_HUMAN
NC score	0.113755 (rank : 37)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	223	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_MOUSE
NC score	0.112719 (rank : 38)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX21_HUMAN
NC score	0.111497 (rank : 39)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	308	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

BLM_HUMAN
NC score	0.111121 (rank : 40)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

DDX28_MOUSE
NC score	0.108618 (rank : 41)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX55_HUMAN
NC score	0.106870 (rank : 42)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX41_HUMAN
NC score	0.106850 (rank : 43)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
NC score	0.106759 (rank : 44)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX54_HUMAN
NC score	0.106758 (rank : 45)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	71	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX3Y_MOUSE
NC score	0.106740 (rank : 46)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	126	Shared Neighborhood Hits	37
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX54_MOUSE
NC score	0.106175 (rank : 47)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	38
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX55_MOUSE
NC score	0.105702 (rank : 48)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

BLM_MOUSE
NC score	0.104751 (rank : 49)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	71	Target Neighborhood Hits	108	Shared Neighborhood Hits	28
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

DDX17_MOUSE
NC score	0.104211 (rank : 50)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	36
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.104187 (rank : 51)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	71	Target Neighborhood Hits	104	Shared Neighborhood Hits	36
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX50_HUMAN
NC score	0.104133 (rank : 52)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	71	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
NC score	0.103831 (rank : 53)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	71	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX21_MOUSE
NC score	0.103215 (rank : 54)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	71	Target Neighborhood Hits	350	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX47_HUMAN
NC score	0.103098 (rank : 55)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
NC score	0.102909 (rank : 56)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	36
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX10_HUMAN
NC score	0.102739 (rank : 57)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	71	Target Neighborhood Hits	210	Shared Neighborhood Hits	34
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX5_HUMAN
NC score	0.102582 (rank : 58)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
NC score	0.102546 (rank : 59)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	71	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX3X_MOUSE
NC score	0.102239 (rank : 60)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	71	Target Neighborhood Hits	117	Shared Neighborhood Hits	36
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3X_HUMAN
NC score	0.102001 (rank : 61)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	71	Target Neighborhood Hits	122	Shared Neighborhood Hits	36
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3Y_HUMAN
NC score	0.101826 (rank : 62)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	36
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

PL10_MOUSE
NC score	0.101106 (rank : 63)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	71	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX27_HUMAN
NC score	0.100932 (rank : 64)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	71	Target Neighborhood Hits	197	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX18_MOUSE
NC score	0.100920 (rank : 65)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	71	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX27_MOUSE
NC score	0.100098 (rank : 66)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	71	Target Neighborhood Hits	174	Shared Neighborhood Hits	36
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX23_HUMAN
NC score	0.099011 (rank : 67)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	71	Target Neighborhood Hits	486	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX53_HUMAN
NC score	0.098551 (rank : 68)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

IF4A1_HUMAN
NC score	0.098330 (rank : 69)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	71	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.098330 (rank : 70)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	71	Target Neighborhood Hits	106	Shared Neighborhood Hits	40
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
NC score	0.097998 (rank : 71)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.097998 (rank : 72)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX48_HUMAN
NC score	0.097975 (rank : 73)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.097925 (rank : 74)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	71	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX39_HUMAN
NC score	0.091722 (rank : 75)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	71	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX56_MOUSE
NC score	0.090924 (rank : 76)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX39_MOUSE
NC score	0.090920 (rank : 77)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	71	Target Neighborhood Hits	97	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX28_HUMAN
NC score	0.090149 (rank : 78)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	71	Target Neighborhood Hits	103	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX18_HUMAN
NC score	0.089994 (rank : 79)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	71	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX25_MOUSE
NC score	0.089932 (rank : 80)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	71	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
NC score	0.089713 (rank : 81)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX24_HUMAN
NC score	0.089487 (rank : 82)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	71	Target Neighborhood Hits	190	Shared Neighborhood Hits	35
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
NC score	0.088807 (rank : 83)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX10_MOUSE
NC score	0.088628 (rank : 84)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	71	Target Neighborhood Hits	233	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

UAP56_MOUSE
NC score	0.088430 (rank : 85)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

UAP56_HUMAN
NC score	0.088422 (rank : 86)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	71	Target Neighborhood Hits	96	Shared Neighborhood Hits	34
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

DDX56_HUMAN
NC score	0.086461 (rank : 87)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DD19A_MOUSE
NC score	0.085992 (rank : 88)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	71	Target Neighborhood Hits	105	Shared Neighborhood Hits	33
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
NC score	0.085723 (rank : 89)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	71	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_HUMAN
NC score	0.085527 (rank : 90)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DDX20_MOUSE
NC score	0.084360 (rank : 91)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	71	Target Neighborhood Hits	177	Shared Neighborhood Hits	33
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX20_HUMAN
NC score	0.084259 (rank : 92)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX1_MOUSE
NC score	0.083228 (rank : 93)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.082752 (rank : 94)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	71	Target Neighborhood Hits	110	Shared Neighborhood Hits	32
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

WDR63_HUMAN
NC score	0.050650 (rank : 95)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWG1, Q96L72, Q96NU4	Gene names	WDR63
Domain Architecture	No domain graphic available
Description	WD repeat protein 63 (Testis development protein NYD-SP29).

EXOC7_HUMAN
NC score	0.039543 (rank : 96)	θ value	1.81305 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UPT5, Q8ND93, Q8WV91, Q96FF0, Q9H8C3, Q9H9X3, Q9HA32	Gene names	EXOC7, EXO70, KIAA1067
Domain Architecture
Description	Exocyst complex component 7 (Exocyst complex component Exo70).

EXOC7_MOUSE
NC score	0.038119 (rank : 97)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	O35250, Q8K121	Gene names	Exoc7, Exo70
Domain Architecture
Description	Exocyst complex component 7 (Exocyst complex component Exo70).

EVA1_HUMAN
NC score	0.024460 (rank : 98)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O60487	Gene names	EVA1, EVA
Domain Architecture
Description	Epithelial V-like antigen 1 precursor.

KLD8A_MOUSE
NC score	0.020489 (rank : 99)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q91XA8	Gene names	Klhdc8a
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 8A.

GRIA2_MOUSE
NC score	0.016344 (rank : 100)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	P23819, Q61604, Q61605, Q8BG69, Q8BXU3, Q9D6D3	Gene names	Gria2, Glur2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

GRIA2_HUMAN
NC score	0.016326 (rank : 101)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	47	Shared Neighborhood Hits	5
SwissProt Accessions	P42262, Q96FP6	Gene names	GRIA2, GLUR2
Domain Architecture
Description	Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

TDRD1_HUMAN
NC score	0.015224 (rank : 102)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXT4, Q9H7B3	Gene names	TDRD1
Domain Architecture
Description	Tudor domain-containing protein 1.

P5CR1_HUMAN
NC score	0.015185 (rank : 103)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P32322, Q6FHI4, Q96DI6	Gene names	PYCR1
Domain Architecture
Description	Pyrroline-5-carboxylate reductase 1 (EC 1.5.1.2) (P5CR 1) (P5C reductase 1).

GRIA1_HUMAN
NC score	0.015096 (rank : 104)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	5
SwissProt Accessions	P42261	Gene names	GRIA1, GLUH1, GLUR1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

GRIA1_MOUSE
NC score	0.014509 (rank : 105)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	5
SwissProt Accessions	P23818	Gene names	Gria1, Glur1
Domain Architecture
Description	Glutamate receptor 1 precursor (GluR-1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) (AMPA-selective glutamate receptor 1).

LMBL2_MOUSE
NC score	0.014502 (rank : 106)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P59178	Gene names	L3mbtl2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

LMBL2_HUMAN
NC score	0.014464 (rank : 107)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	33	Shared Neighborhood Hits	3
SwissProt Accessions	Q969R5, Q8TEN1, Q96SC4, Q9BQI2, Q9UGS4	Gene names	L3MBTL2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

JIP3_MOUSE
NC score	0.013605 (rank : 108)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	759	Shared Neighborhood Hits	7
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

ERAL_MOUSE
NC score	0.012923 (rank : 109)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CZU4, Q6NV78, Q925U1	Gene names	Eral1
Domain Architecture	No domain graphic available
Description	GTP-binding protein era homolog (ERA-W) (Conserved ERA-like GTPase) (CEGA).

IWS1_HUMAN
NC score	0.012810 (rank : 110)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	1241	Shared Neighborhood Hits	12
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JIP3_HUMAN
NC score	0.012449 (rank : 111)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	1039	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

ZFYV9_HUMAN
NC score	0.012024 (rank : 112)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

BRWD1_HUMAN
NC score	0.012005 (rank : 113)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	448	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NSI6, O43721, Q5R2V0, Q5R2V1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1	Gene names	BRWD1, C21orf107, WDR9
Domain Architecture
Description	Bromodomain and WD repeat domain-containing protein 1 (WD repeat protein 9).

MSH4_MOUSE
NC score	0.010886 (rank : 114)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MT2, Q920J1	Gene names	Msh4
Domain Architecture
Description	MutS protein homolog 4 (mMsh4).

CCNB3_HUMAN
NC score	0.007892 (rank : 115)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

ATM_HUMAN
NC score	0.007852 (rank : 116)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

MYO6_MOUSE
NC score	0.007502 (rank : 117)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

PLCB4_HUMAN
NC score	0.006990 (rank : 118)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	658	Shared Neighborhood Hits	7
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

BTBD5_HUMAN
NC score	0.006438 (rank : 119)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	190	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXS3	Gene names	BTBD5
Domain Architecture
Description	BTB/POZ domain-containing protein 5.

MYO5C_HUMAN
NC score	0.005106 (rank : 120)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	1206	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

GLTL2_MOUSE
NC score	0.003896 (rank : 121)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2N8	Gene names	Galntl2
Domain Architecture	No domain graphic available
Description	Polypeptide N-acetylgalactosaminyltransferase-like protein 2 (EC 2.4.1.41) (Protein-UDP acetylgalactosaminyltransferase-like protein 2) (UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase- like protein 2) (Polypeptide GalNAc transferase-like protein 2) (GalNAc-T-like protein 2) (pp-GaNTase-like protein 2).

ZN545_HUMAN
NC score	-0.001785 (rank : 122)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N141, Q8NC63, Q8TF53	Gene names	ZNF545, KIAA1948
Domain Architecture	No domain graphic available
Description	Zinc finger protein 545.