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Network neighborhood for query Sequence : DDX54_MOUSE

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DDX54_MOUSE
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDX54_HUMAN
θ value	0 (rank : 1)	NC score	0.995115 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX54_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX27_MOUSE
θ value	4.53632e-60 (rank : 3)	NC score	0.965443 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	85
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX49_HUMAN
θ value	5.0155e-59 (rank : 4)	NC score	0.967088 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	223	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX46_HUMAN
θ value	6.55044e-59 (rank : 5)	NC score	0.945099 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	357	Shared Neighborhood Hits	94
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	6.55044e-59 (rank : 6)	NC score	0.942740 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	358	Shared Neighborhood Hits	94
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX49_MOUSE
θ value	6.55044e-59 (rank : 7)	NC score	0.970935 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_HUMAN
θ value	7.24236e-58 (rank : 8)	NC score	0.963870 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	197	Shared Neighborhood Hits	87
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX47_MOUSE
θ value	1.36585e-56 (rank : 9)	NC score	0.971602 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_HUMAN
θ value	2.32979e-56 (rank : 10)	NC score	0.971152 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX23_HUMAN
θ value	6.34462e-54 (rank : 11)	NC score	0.935619 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX53_HUMAN
θ value	1.91031e-50 (rank : 12)	NC score	0.957707 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	82
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX6_HUMAN
θ value	2.49495e-50 (rank : 13)	NC score	0.964940 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	2.49495e-50 (rank : 14)	NC score	0.964760 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	87
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX48_HUMAN
θ value	1.23823e-49 (rank : 15)	NC score	0.956928 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	1.23823e-49 (rank : 16)	NC score	0.956755 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX10_HUMAN
θ value	4.70527e-49 (rank : 17)	NC score	0.951153 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	4.70527e-49 (rank : 18)	NC score	0.950503 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	233	Shared Neighborhood Hits	82
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX3X_MOUSE
θ value	1.04822e-48 (rank : 19)	NC score	0.947716 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3X_HUMAN
θ value	1.788e-48 (rank : 20)	NC score	0.948023 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX41_HUMAN
θ value	3.98324e-48 (rank : 21)	NC score	0.960865 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	5.20228e-48 (rank : 22)	NC score	0.960371 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX4_MOUSE
θ value	8.87376e-48 (rank : 23)	NC score	0.958118 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

PL10_MOUSE
θ value	1.97686e-47 (rank : 24)	NC score	0.948090 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX4_HUMAN
θ value	2.58187e-47 (rank : 25)	NC score	0.957230 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX5_HUMAN
θ value	2.58187e-47 (rank : 26)	NC score	0.953787 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX17_HUMAN
θ value	3.37202e-47 (rank : 27)	NC score	0.956518 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	85
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	3.37202e-47 (rank : 28)	NC score	0.956654 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	85
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX5_MOUSE
θ value	5.7518e-47 (rank : 29)	NC score	0.953831 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX43_HUMAN
θ value	9.81109e-47 (rank : 30)	NC score	0.960126 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX3Y_HUMAN
θ value	1.67352e-46 (rank : 31)	NC score	0.946269 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	85
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX3Y_MOUSE
θ value	2.85459e-46 (rank : 32)	NC score	0.948420 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

IF4A1_HUMAN
θ value	4.86918e-46 (rank : 33)	NC score	0.953307 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	4.86918e-46 (rank : 34)	NC score	0.953307 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
θ value	1.85029e-45 (rank : 35)	NC score	0.952829 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	1.85029e-45 (rank : 36)	NC score	0.952829 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX18_MOUSE
θ value	1.19932e-44 (rank : 37)	NC score	0.956406 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX31_HUMAN
θ value	2.67181e-44 (rank : 38)	NC score	0.952676 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX18_HUMAN
θ value	1.73182e-43 (rank : 39)	NC score	0.955245 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX52_HUMAN
θ value	1.62093e-41 (rank : 40)	NC score	0.958405 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
θ value	2.76489e-41 (rank : 41)	NC score	0.958402 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX50_MOUSE
θ value	3.99248e-40 (rank : 42)	NC score	0.943299 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	137	Shared Neighborhood Hits	89
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX55_HUMAN
θ value	1.16164e-39 (rank : 43)	NC score	0.954559 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

UAP56_HUMAN
θ value	1.98146e-39 (rank : 44)	NC score	0.950253 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	1.98146e-39 (rank : 45)	NC score	0.950176 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX50_HUMAN
θ value	2.58786e-39 (rank : 46)	NC score	0.942992 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX39_MOUSE
θ value	1.28434e-38 (rank : 47)	NC score	0.950563 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX55_MOUSE
θ value	1.6774e-38 (rank : 48)	NC score	0.955230 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX39_HUMAN
θ value	6.37413e-38 (rank : 49)	NC score	0.950703 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	84
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX21_MOUSE
θ value	1.42001e-37 (rank : 50)	NC score	0.922702 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	350	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX21_HUMAN
θ value	1.85459e-37 (rank : 51)	NC score	0.930569 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	308	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX56_MOUSE
θ value	2.05049e-36 (rank : 52)	NC score	0.952691 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX56_HUMAN
θ value	1.01765e-35 (rank : 53)	NC score	0.952770 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	77	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX20_HUMAN
θ value	2.96089e-35 (rank : 54)	NC score	0.939633 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX28_MOUSE
θ value	2.96089e-35 (rank : 55)	NC score	0.954407 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX20_MOUSE
θ value	7.29293e-34 (rank : 56)	NC score	0.936340 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX25_HUMAN
θ value	1.24399e-33 (rank : 57)	NC score	0.932116 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	3.61944e-33 (rank : 58)	NC score	0.930825 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DD19A_HUMAN
θ value	2.34606e-32 (rank : 59)	NC score	0.929779 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	2.34606e-32 (rank : 60)	NC score	0.929168 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	81
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	3.06405e-32 (rank : 61)	NC score	0.929068 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX24_MOUSE
θ value	5.22648e-32 (rank : 62)	NC score	0.934685 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	147	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_HUMAN
θ value	1.52067e-31 (rank : 63)	NC score	0.931930 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	190	Shared Neighborhood Hits	83
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX28_HUMAN
θ value	2.42779e-29 (rank : 64)	NC score	0.950211 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX51_MOUSE
θ value	1.2049e-28 (rank : 65)	NC score	0.931806 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	86
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_MOUSE
θ value	4.28545e-26 (rank : 66)	NC score	0.891073 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX51_HUMAN
θ value	5.59698e-26 (rank : 67)	NC score	0.913958 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_HUMAN
θ value	2.77775e-25 (rank : 68)	NC score	0.889330 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	81
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

WRN_HUMAN
θ value	2.88788e-06 (rank : 69)	NC score	0.474014 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

BLM_HUMAN
θ value	8.40245e-06 (rank : 70)	NC score	0.485367 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	148	Shared Neighborhood Hits	76
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	1.43324e-05 (rank : 71)	NC score	0.498987 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

WRN_MOUSE
θ value	0.000602161 (rank : 72)	NC score	0.438735 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	295	Shared Neighborhood Hits	82
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ5_HUMAN
θ value	0.00228821 (rank : 73)	NC score	0.455393 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	78
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

SK2L2_HUMAN
θ value	0.0193708 (rank : 74)	NC score	0.063321 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SK2L2_MOUSE
θ value	0.0193708 (rank : 75)	NC score	0.063154 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SKIV2_HUMAN
θ value	0.0252991 (rank : 76)	NC score	0.084729 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

DHX57_HUMAN
θ value	0.0330416 (rank : 77)	NC score	0.018176 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

RECQ4_MOUSE
θ value	0.0736092 (rank : 78)	NC score	0.517541 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	88
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ1_HUMAN
θ value	0.0961366 (rank : 79)	NC score	0.426739 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

IFIH1_MOUSE
θ value	0.125558 (rank : 80)	NC score	0.298916 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

RECQ4_HUMAN
θ value	0.163984 (rank : 81)	NC score	0.530757 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	88
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

IFIH1_HUMAN
θ value	0.21417 (rank : 82)	NC score	0.314662 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

PRP16_HUMAN
θ value	0.365318 (rank : 83)	NC score	0.026042 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	135	Shared Neighborhood Hits	16
SwissProt Accessions	Q92620, O75212, Q96HN7	Gene names	DHX38, DDX38, KIAA0224, PRP16
Domain Architecture
Description	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.1.-) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38).

RECQ1_MOUSE
θ value	0.47712 (rank : 84)	NC score	0.423684 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	95	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DICER_MOUSE
θ value	0.62314 (rank : 85)	NC score	0.376487 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

MLL2_HUMAN
θ value	0.62314 (rank : 86)	NC score	0.000070 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	1788	Shared Neighborhood Hits	11
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

L2GL2_HUMAN
θ value	0.813845 (rank : 87)	NC score	0.008206 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1M3, Q14521, Q9BR62	Gene names	LLGL2
Domain Architecture	No domain graphic available
Description	Lethal(2) giant larvae protein homolog 2 (HGL).

TRHY_HUMAN
θ value	0.813845 (rank : 88)	NC score	0.000390 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	1385	Shared Neighborhood Hits	15
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

DICER_HUMAN
θ value	1.06291 (rank : 89)	NC score	0.377124 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

LGP2_HUMAN
θ value	1.06291 (rank : 90)	NC score	0.299484 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	72
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

MAGC3_HUMAN
θ value	1.06291 (rank : 91)	NC score	0.006877 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD91, Q5JZ43, Q9BZ80	Gene names	MAGEC3, HCA2
Domain Architecture
Description	Melanoma-associated antigen C3 (MAGE-C3 antigen) (Hepatocellular carcinoma-associated antigen 2).

U520_HUMAN
θ value	1.06291 (rank : 92)	NC score	0.144441 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

SPEG_MOUSE
θ value	1.38821 (rank : 93)	NC score	-0.005812 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	18
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DPOG1_HUMAN
θ value	1.81305 (rank : 94)	NC score	0.010693 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

PERQ1_MOUSE
θ value	1.81305 (rank : 95)	NC score	0.016598 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	215	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

SFRIP_HUMAN
θ value	1.81305 (rank : 96)	NC score	0.043137 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	530	Shared Neighborhood Hits	18
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SRRM2_MOUSE
θ value	1.81305 (rank : 97)	NC score	0.012239 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	1470	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

CDX2_MOUSE
θ value	2.36792 (rank : 98)	NC score	-0.001544 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	336	Shared Neighborhood Hits	2
SwissProt Accessions	P43241	Gene names	Cdx2, Cdx-2
Domain Architecture
Description	Homeobox protein CDX-2 (Caudal-type homeobox protein 2).

DDX58_HUMAN
θ value	2.36792 (rank : 99)	NC score	0.158761 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	55
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

BAP1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.010381 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q92560, Q6LEM0, Q7Z5E8	Gene names	BAP1, KIAA0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Cerebral protein 6).

SFR12_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.010574 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	553	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

TM16H_MOUSE
θ value	3.0926 (rank : 102)	NC score	0.007281 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PB70, Q69ZE4	Gene names	Tmem16h, Kiaa1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

BAP1_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.009810 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

BRCA1_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.002135 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

RPTN_MOUSE
θ value	4.03905 (rank : 105)	NC score	0.023692 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	650	Shared Neighborhood Hits	25
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

T2_MOUSE
θ value	4.03905 (rank : 106)	NC score	0.029993 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

ANK1_MOUSE
θ value	5.27518 (rank : 107)	NC score	-0.002734 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	430	Shared Neighborhood Hits	6
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

CROP_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.004428 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	402	Shared Neighborhood Hits	11
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

CROP_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.004498 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	403	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

DDX58_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.190672 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

HIRP3_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.006456 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

PRKDC_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.005503 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

SCN2A_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.001585 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SPTN2_HUMAN
θ value	5.27518 (rank : 114)	NC score	-0.001022 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	535	Shared Neighborhood Hits	5
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

BAZ2A_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.003336 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

IF2P_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.000291 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	889	Shared Neighborhood Hits	13
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

MYPT1_HUMAN
θ value	6.88961 (rank : 117)	NC score	-0.001027 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	723	Shared Neighborhood Hits	8
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

NCOA1_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.002496 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

ZC11A_MOUSE
θ value	6.88961 (rank : 119)	NC score	0.006221 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

FILA_HUMAN
θ value	8.99809 (rank : 120)	NC score	0.032768 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	685	Shared Neighborhood Hits	26
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

IWS1_MOUSE
θ value	8.99809 (rank : 121)	NC score	0.016727 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	1258	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LGP2_MOUSE
θ value	8.99809 (rank : 122)	NC score	0.312274 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

LRC59_MOUSE
θ value	8.99809 (rank : 123)	NC score	-0.001634 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	415	Shared Neighborhood Hits	3
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

UB7I3_MOUSE
θ value	8.99809 (rank : 124)	NC score	0.002183 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

CC026_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.156817 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

CC026_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.128061 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

FANCM_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.387014 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.384397 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

HELC1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.106175 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.071195 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

Hits sorted by NC score

DDX54_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX54_HUMAN
NC score	0.995115 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	124	Target Neighborhood Hits	170	Shared Neighborhood Hits	97
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX47_MOUSE
NC score	0.971602 (rank : 3)	θ value	1.36585e-56 (rank : 9)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_HUMAN
NC score	0.971152 (rank : 4)	θ value	2.32979e-56 (rank : 10)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX49_MOUSE
NC score	0.970935 (rank : 5)	θ value	6.55044e-59 (rank : 7)
Query Neighborhood Hits	124	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_HUMAN
NC score	0.967088 (rank : 6)	θ value	5.0155e-59 (rank : 4)
Query Neighborhood Hits	124	Target Neighborhood Hits	223	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_MOUSE
NC score	0.965443 (rank : 7)	θ value	4.53632e-60 (rank : 3)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	85
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX6_HUMAN
NC score	0.964940 (rank : 8)	θ value	2.49495e-50 (rank : 13)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.964760 (rank : 9)	θ value	2.49495e-50 (rank : 14)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	87
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX27_HUMAN
NC score	0.963870 (rank : 10)	θ value	7.24236e-58 (rank : 8)
Query Neighborhood Hits	124	Target Neighborhood Hits	197	Shared Neighborhood Hits	87
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX41_HUMAN
NC score	0.960865 (rank : 11)	θ value	3.98324e-48 (rank : 21)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
NC score	0.960371 (rank : 12)	θ value	5.20228e-48 (rank : 22)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX43_HUMAN
NC score	0.960126 (rank : 13)	θ value	9.81109e-47 (rank : 30)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX52_HUMAN
NC score	0.958405 (rank : 14)	θ value	1.62093e-41 (rank : 40)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
NC score	0.958402 (rank : 15)	θ value	2.76489e-41 (rank : 41)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX4_MOUSE
NC score	0.958118 (rank : 16)	θ value	8.87376e-48 (rank : 23)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	87
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX53_HUMAN
NC score	0.957707 (rank : 17)	θ value	1.91031e-50 (rank : 12)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	82
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX4_HUMAN
NC score	0.957230 (rank : 18)	θ value	2.58187e-47 (rank : 25)
Query Neighborhood Hits	124	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX48_HUMAN
NC score	0.956928 (rank : 19)	θ value	1.23823e-49 (rank : 15)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.956755 (rank : 20)	θ value	1.23823e-49 (rank : 16)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX17_MOUSE
NC score	0.956654 (rank : 21)	θ value	3.37202e-47 (rank : 28)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	85
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.956518 (rank : 22)	θ value	3.37202e-47 (rank : 27)
Query Neighborhood Hits	124	Target Neighborhood Hits	104	Shared Neighborhood Hits	85
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX18_MOUSE
NC score	0.956406 (rank : 23)	θ value	1.19932e-44 (rank : 37)
Query Neighborhood Hits	124	Target Neighborhood Hits	115	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX18_HUMAN
NC score	0.955245 (rank : 24)	θ value	1.73182e-43 (rank : 39)
Query Neighborhood Hits	124	Target Neighborhood Hits	124	Shared Neighborhood Hits	79
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX55_MOUSE
NC score	0.955230 (rank : 25)	θ value	1.6774e-38 (rank : 48)
Query Neighborhood Hits	124	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_HUMAN
NC score	0.954559 (rank : 26)	θ value	1.16164e-39 (rank : 43)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX28_MOUSE
NC score	0.954407 (rank : 27)	θ value	2.96089e-35 (rank : 55)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX5_MOUSE
NC score	0.953831 (rank : 28)	θ value	5.7518e-47 (rank : 29)
Query Neighborhood Hits	124	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX5_HUMAN
NC score	0.953787 (rank : 29)	θ value	2.58187e-47 (rank : 26)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

IF4A1_HUMAN
NC score	0.953307 (rank : 30)	θ value	4.86918e-46 (rank : 33)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.953307 (rank : 31)	θ value	4.86918e-46 (rank : 34)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
NC score	0.952829 (rank : 32)	θ value	1.85029e-45 (rank : 35)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.952829 (rank : 33)	θ value	1.85029e-45 (rank : 36)
Query Neighborhood Hits	124	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX56_HUMAN
NC score	0.952770 (rank : 34)	θ value	1.01765e-35 (rank : 53)
Query Neighborhood Hits	124	Target Neighborhood Hits	77	Shared Neighborhood Hits	74
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
NC score	0.952691 (rank : 35)	θ value	2.05049e-36 (rank : 52)
Query Neighborhood Hits	124	Target Neighborhood Hits	87	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX31_HUMAN
NC score	0.952676 (rank : 36)	θ value	2.67181e-44 (rank : 38)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX10_HUMAN
NC score	0.951153 (rank : 37)	θ value	4.70527e-49 (rank : 17)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX39_HUMAN
NC score	0.950703 (rank : 38)	θ value	6.37413e-38 (rank : 49)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	84
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
NC score	0.950563 (rank : 39)	θ value	1.28434e-38 (rank : 47)
Query Neighborhood Hits	124	Target Neighborhood Hits	97	Shared Neighborhood Hits	83
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX10_MOUSE
NC score	0.950503 (rank : 40)	θ value	4.70527e-49 (rank : 18)
Query Neighborhood Hits	124	Target Neighborhood Hits	233	Shared Neighborhood Hits	82
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

UAP56_HUMAN
NC score	0.950253 (rank : 41)	θ value	1.98146e-39 (rank : 44)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

DDX28_HUMAN
NC score	0.950211 (rank : 42)	θ value	2.42779e-29 (rank : 64)
Query Neighborhood Hits	124	Target Neighborhood Hits	103	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

UAP56_MOUSE
NC score	0.950176 (rank : 43)	θ value	1.98146e-39 (rank : 45)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX3Y_MOUSE
NC score	0.948420 (rank : 44)	θ value	2.85459e-46 (rank : 32)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

PL10_MOUSE
NC score	0.948090 (rank : 45)	θ value	1.97686e-47 (rank : 24)
Query Neighborhood Hits	124	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_HUMAN
NC score	0.948023 (rank : 46)	θ value	1.788e-48 (rank : 20)
Query Neighborhood Hits	124	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
NC score	0.947716 (rank : 47)	θ value	1.04822e-48 (rank : 19)
Query Neighborhood Hits	124	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
NC score	0.946269 (rank : 48)	θ value	1.67352e-46 (rank : 31)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	85
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX46_HUMAN
NC score	0.945099 (rank : 49)	θ value	6.55044e-59 (rank : 5)
Query Neighborhood Hits	124	Target Neighborhood Hits	357	Shared Neighborhood Hits	94
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX50_MOUSE
NC score	0.943299 (rank : 50)	θ value	3.99248e-40 (rank : 42)
Query Neighborhood Hits	124	Target Neighborhood Hits	137	Shared Neighborhood Hits	89
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_HUMAN
NC score	0.942992 (rank : 51)	θ value	2.58786e-39 (rank : 46)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX46_MOUSE
NC score	0.942740 (rank : 52)	θ value	6.55044e-59 (rank : 6)
Query Neighborhood Hits	124	Target Neighborhood Hits	358	Shared Neighborhood Hits	94
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX20_HUMAN
NC score	0.939633 (rank : 53)	θ value	2.96089e-35 (rank : 54)
Query Neighborhood Hits	124	Target Neighborhood Hits	121	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
NC score	0.936340 (rank : 54)	θ value	7.29293e-34 (rank : 56)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX23_HUMAN
NC score	0.935619 (rank : 55)	θ value	6.34462e-54 (rank : 11)
Query Neighborhood Hits	124	Target Neighborhood Hits	486	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX24_MOUSE
NC score	0.934685 (rank : 56)	θ value	5.22648e-32 (rank : 62)
Query Neighborhood Hits	124	Target Neighborhood Hits	147	Shared Neighborhood Hits	85
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX25_HUMAN
NC score	0.932116 (rank : 57)	θ value	1.24399e-33 (rank : 57)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX24_HUMAN
NC score	0.931930 (rank : 58)	θ value	1.52067e-31 (rank : 63)
Query Neighborhood Hits	124	Target Neighborhood Hits	190	Shared Neighborhood Hits	83
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX51_MOUSE
NC score	0.931806 (rank : 59)	θ value	1.2049e-28 (rank : 65)
Query Neighborhood Hits	124	Target Neighborhood Hits	130	Shared Neighborhood Hits	86
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX25_MOUSE
NC score	0.930825 (rank : 60)	θ value	3.61944e-33 (rank : 58)
Query Neighborhood Hits	124	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX21_HUMAN
NC score	0.930569 (rank : 61)	θ value	1.85459e-37 (rank : 51)
Query Neighborhood Hits	124	Target Neighborhood Hits	308	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DD19A_HUMAN
NC score	0.929779 (rank : 62)	θ value	2.34606e-32 (rank : 59)
Query Neighborhood Hits	124	Target Neighborhood Hits	107	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
NC score	0.929168 (rank : 63)	θ value	2.34606e-32 (rank : 60)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	81
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
NC score	0.929068 (rank : 64)	θ value	3.06405e-32 (rank : 61)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX21_MOUSE
NC score	0.922702 (rank : 65)	θ value	1.42001e-37 (rank : 50)
Query Neighborhood Hits	124	Target Neighborhood Hits	350	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX51_HUMAN
NC score	0.913958 (rank : 66)	θ value	5.59698e-26 (rank : 67)
Query Neighborhood Hits	124	Target Neighborhood Hits	332	Shared Neighborhood Hits	90
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_MOUSE
NC score	0.891073 (rank : 67)	θ value	4.28545e-26 (rank : 66)
Query Neighborhood Hits	124	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.889330 (rank : 68)	θ value	2.77775e-25 (rank : 68)
Query Neighborhood Hits	124	Target Neighborhood Hits	110	Shared Neighborhood Hits	81
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

RECQ4_HUMAN
NC score	0.530757 (rank : 69)	θ value	0.163984 (rank : 81)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	88
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.517541 (rank : 70)	θ value	0.0736092 (rank : 78)
Query Neighborhood Hits	124	Target Neighborhood Hits	206	Shared Neighborhood Hits	88
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

BLM_MOUSE
NC score	0.498987 (rank : 71)	θ value	1.43324e-05 (rank : 71)
Query Neighborhood Hits	124	Target Neighborhood Hits	108	Shared Neighborhood Hits	72
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.485367 (rank : 72)	θ value	8.40245e-06 (rank : 70)
Query Neighborhood Hits	124	Target Neighborhood Hits	148	Shared Neighborhood Hits	76
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

WRN_HUMAN
NC score	0.474014 (rank : 73)	θ value	2.88788e-06 (rank : 69)
Query Neighborhood Hits	124	Target Neighborhood Hits	132	Shared Neighborhood Hits	82
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ5_HUMAN
NC score	0.455393 (rank : 74)	θ value	0.00228821 (rank : 73)
Query Neighborhood Hits	124	Target Neighborhood Hits	390	Shared Neighborhood Hits	78
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_MOUSE
NC score	0.438735 (rank : 75)	θ value	0.000602161 (rank : 72)
Query Neighborhood Hits	124	Target Neighborhood Hits	295	Shared Neighborhood Hits	82
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ1_HUMAN
NC score	0.426739 (rank : 76)	θ value	0.0961366 (rank : 79)
Query Neighborhood Hits	124	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
NC score	0.423684 (rank : 77)	θ value	0.47712 (rank : 84)
Query Neighborhood Hits	124	Target Neighborhood Hits	95	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

FANCM_HUMAN
NC score	0.387014 (rank : 78)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	124	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.384397 (rank : 79)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	124	Target Neighborhood Hits	177	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

DICER_HUMAN
NC score	0.377124 (rank : 80)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.376487 (rank : 81)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

IFIH1_HUMAN
NC score	0.314662 (rank : 82)	θ value	0.21417 (rank : 82)
Query Neighborhood Hits	124	Target Neighborhood Hits	96	Shared Neighborhood Hits	76
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
NC score	0.312274 (rank : 83)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	124	Target Neighborhood Hits	86	Shared Neighborhood Hits	69
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

LGP2_HUMAN
NC score	0.299484 (rank : 84)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	124	Target Neighborhood Hits	94	Shared Neighborhood Hits	72
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_MOUSE
NC score	0.298916 (rank : 85)	θ value	0.125558 (rank : 80)
Query Neighborhood Hits	124	Target Neighborhood Hits	126	Shared Neighborhood Hits	80
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DDX58_MOUSE
NC score	0.190672 (rank : 86)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	124	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
NC score	0.158761 (rank : 87)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	124	Target Neighborhood Hits	105	Shared Neighborhood Hits	55
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_HUMAN
NC score	0.156817 (rank : 88)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	124	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

U520_HUMAN
NC score	0.144441 (rank : 89)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	124	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

CC026_MOUSE
NC score	0.128061 (rank : 90)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	124	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

HELC1_HUMAN
NC score	0.106175 (rank : 91)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SKIV2_HUMAN
NC score	0.084729 (rank : 92)	θ value	0.0252991 (rank : 76)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	23
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

SMAL1_HUMAN
NC score	0.071195 (rank : 93)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	124	Target Neighborhood Hits	174	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SK2L2_HUMAN
NC score	0.063321 (rank : 94)	θ value	0.0193708 (rank : 74)
Query Neighborhood Hits	124	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SK2L2_MOUSE
NC score	0.063154 (rank : 95)	θ value	0.0193708 (rank : 75)
Query Neighborhood Hits	124	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SFRIP_HUMAN
NC score	0.043137 (rank : 96)	θ value	1.81305 (rank : 96)
Query Neighborhood Hits	124	Target Neighborhood Hits	530	Shared Neighborhood Hits	18
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

FILA_HUMAN
NC score	0.032768 (rank : 97)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	124	Target Neighborhood Hits	685	Shared Neighborhood Hits	26
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

T2_MOUSE
NC score	0.029993 (rank : 98)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	124	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

PRP16_HUMAN
NC score	0.026042 (rank : 99)	θ value	0.365318 (rank : 83)
Query Neighborhood Hits	124	Target Neighborhood Hits	135	Shared Neighborhood Hits	16
SwissProt Accessions	Q92620, O75212, Q96HN7	Gene names	DHX38, DDX38, KIAA0224, PRP16
Domain Architecture
Description	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.1.-) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38).

RPTN_MOUSE
NC score	0.023692 (rank : 100)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	124	Target Neighborhood Hits	650	Shared Neighborhood Hits	25
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

DHX57_HUMAN
NC score	0.018176 (rank : 101)	θ value	0.0330416 (rank : 77)
Query Neighborhood Hits	124	Target Neighborhood Hits	109	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P158, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33	Gene names	DHX57
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX57 (EC 3.6.1.-) (DEAH box protein 57).

IWS1_MOUSE
NC score	0.016727 (rank : 102)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	124	Target Neighborhood Hits	1258	Shared Neighborhood Hits	29
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PERQ1_MOUSE
NC score	0.016598 (rank : 103)	θ value	1.81305 (rank : 95)
Query Neighborhood Hits	124	Target Neighborhood Hits	215	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

SRRM2_MOUSE
NC score	0.012239 (rank : 104)	θ value	1.81305 (rank : 97)
Query Neighborhood Hits	124	Target Neighborhood Hits	1470	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

DPOG1_HUMAN
NC score	0.010693 (rank : 105)	θ value	1.81305 (rank : 94)
Query Neighborhood Hits	124	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P54098, Q8NFM2, Q92515	Gene names	POLG, MDP1, POLG1, POLGA
Domain Architecture
Description	DNA polymerase subunit gamma 1 (EC 2.7.7.7) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha).

SFR12_HUMAN
NC score	0.010574 (rank : 106)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	124	Target Neighborhood Hits	553	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

BAP1_HUMAN
NC score	0.010381 (rank : 107)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	124	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q92560, Q6LEM0, Q7Z5E8	Gene names	BAP1, KIAA0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Cerebral protein 6).

BAP1_MOUSE
NC score	0.009810 (rank : 108)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	124	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

L2GL2_HUMAN
NC score	0.008206 (rank : 109)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P1M3, Q14521, Q9BR62	Gene names	LLGL2
Domain Architecture	No domain graphic available
Description	Lethal(2) giant larvae protein homolog 2 (HGL).

TM16H_MOUSE
NC score	0.007281 (rank : 110)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	124	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q6PB70, Q69ZE4	Gene names	Tmem16h, Kiaa1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

MAGC3_HUMAN
NC score	0.006877 (rank : 111)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	124	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD91, Q5JZ43, Q9BZ80	Gene names	MAGEC3, HCA2
Domain Architecture
Description	Melanoma-associated antigen C3 (MAGE-C3 antigen) (Hepatocellular carcinoma-associated antigen 2).

HIRP3_HUMAN
NC score	0.006456 (rank : 112)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	124	Target Neighborhood Hits	323	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

ZC11A_MOUSE
NC score	0.006221 (rank : 113)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	124	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

PRKDC_HUMAN
NC score	0.005503 (rank : 114)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	124	Target Neighborhood Hits	93	Shared Neighborhood Hits	3
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

CROP_MOUSE
NC score	0.004498 (rank : 115)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	124	Target Neighborhood Hits	403	Shared Neighborhood Hits	11
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

CROP_HUMAN
NC score	0.004428 (rank : 116)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	124	Target Neighborhood Hits	402	Shared Neighborhood Hits	11
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

BAZ2A_HUMAN
NC score	0.003336 (rank : 117)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	124	Target Neighborhood Hits	780	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

NCOA1_HUMAN
NC score	0.002496 (rank : 118)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	124	Target Neighborhood Hits	198	Shared Neighborhood Hits	4
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

UB7I3_MOUSE
NC score	0.002183 (rank : 119)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	124	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q9WUB0	Gene names	Rbck1, Rbck, Ubce7ip3, Uip28
Domain Architecture
Description	RanBP-type and C3HC4-type zinc finger-containing protein 1 (Ubiquitin- conjugating enzyme 7-interacting protein 3) (UbcM4-interacting protein 28).

BRCA1_MOUSE
NC score	0.002135 (rank : 120)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	124	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

SCN2A_HUMAN
NC score	0.001585 (rank : 121)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	124	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TRHY_HUMAN
NC score	0.000390 (rank : 122)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	124	Target Neighborhood Hits	1385	Shared Neighborhood Hits	15
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

IF2P_HUMAN
NC score	0.000291 (rank : 123)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	124	Target Neighborhood Hits	889	Shared Neighborhood Hits	13
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

MLL2_HUMAN
NC score	0.000070 (rank : 124)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	124	Target Neighborhood Hits	1788	Shared Neighborhood Hits	11
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SPTN2_HUMAN
NC score	-0.001022 (rank : 125)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	124	Target Neighborhood Hits	535	Shared Neighborhood Hits	5
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

MYPT1_HUMAN
NC score	-0.001027 (rank : 126)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	124	Target Neighborhood Hits	723	Shared Neighborhood Hits	8
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

CDX2_MOUSE
NC score	-0.001544 (rank : 127)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	124	Target Neighborhood Hits	336	Shared Neighborhood Hits	2
SwissProt Accessions	P43241	Gene names	Cdx2, Cdx-2
Domain Architecture
Description	Homeobox protein CDX-2 (Caudal-type homeobox protein 2).

LRC59_MOUSE
NC score	-0.001634 (rank : 128)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	124	Target Neighborhood Hits	415	Shared Neighborhood Hits	3
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

ANK1_MOUSE
NC score	-0.002734 (rank : 129)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	124	Target Neighborhood Hits	430	Shared Neighborhood Hits	6
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

SPEG_MOUSE
NC score	-0.005812 (rank : 130)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	124	Target Neighborhood Hits	1959	Shared Neighborhood Hits	18
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).