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Network neighborhood for query Sequence : RECQ1_HUMAN

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RECQ1_HUMAN
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RECQ1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	0 (rank : 2)	NC score	0.995067 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

BLM_MOUSE
θ value	1.94503e-103 (rank : 3)	NC score	0.924977 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
θ value	2.15048e-102 (rank : 4)	NC score	0.921464 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RECQ5_HUMAN
θ value	4.22625e-74 (rank : 5)	NC score	0.867517 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	390	Shared Neighborhood Hits	68
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_HUMAN
θ value	9.43692e-66 (rank : 6)	NC score	0.873212 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

WRN_MOUSE
θ value	8.83269e-64 (rank : 7)	NC score	0.850749 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	295	Shared Neighborhood Hits	76
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ4_HUMAN
θ value	4.2656e-42 (rank : 8)	NC score	0.838152 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
θ value	5.57106e-42 (rank : 9)	NC score	0.827957 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	78
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

DDX49_MOUSE
θ value	6.87365e-08 (rank : 10)	NC score	0.463049 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	119	Shared Neighborhood Hits	75
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX21_MOUSE
θ value	8.97725e-08 (rank : 11)	NC score	0.463883 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX17_HUMAN
θ value	1.17247e-07 (rank : 12)	NC score	0.490964 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	104	Shared Neighborhood Hits	73
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	1.17247e-07 (rank : 13)	NC score	0.491039 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	73
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX21_HUMAN
θ value	1.17247e-07 (rank : 14)	NC score	0.471221 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	308	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX10_MOUSE
θ value	2.61198e-07 (rank : 15)	NC score	0.432554 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	233	Shared Neighborhood Hits	70
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX49_HUMAN
θ value	7.59969e-07 (rank : 16)	NC score	0.460151 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	223	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX43_HUMAN
θ value	9.92553e-07 (rank : 17)	NC score	0.476080 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX53_HUMAN
θ value	9.92553e-07 (rank : 18)	NC score	0.451268 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	70
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX10_HUMAN
θ value	1.29631e-06 (rank : 19)	NC score	0.434668 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	210	Shared Neighborhood Hits	72
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX46_HUMAN
θ value	1.29631e-06 (rank : 20)	NC score	0.477536 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	357	Shared Neighborhood Hits	75
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	1.29631e-06 (rank : 21)	NC score	0.476831 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	358	Shared Neighborhood Hits	75
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX23_HUMAN
θ value	2.21117e-06 (rank : 22)	NC score	0.459817 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	486	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX50_HUMAN
θ value	2.21117e-06 (rank : 23)	NC score	0.478902 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
θ value	2.88788e-06 (rank : 24)	NC score	0.478035 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	137	Shared Neighborhood Hits	74
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX6_HUMAN
θ value	4.92598e-06 (rank : 25)	NC score	0.467106 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	4.92598e-06 (rank : 26)	NC score	0.466962 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX27_MOUSE
θ value	1.09739e-05 (rank : 27)	NC score	0.446168 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX41_HUMAN
θ value	1.09739e-05 (rank : 28)	NC score	0.468412 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	1.09739e-05 (rank : 29)	NC score	0.466433 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	115	Shared Neighborhood Hits	74
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX27_HUMAN
θ value	1.43324e-05 (rank : 30)	NC score	0.444265 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX48_HUMAN
θ value	1.43324e-05 (rank : 31)	NC score	0.450384 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	1.43324e-05 (rank : 32)	NC score	0.450143 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX47_HUMAN
θ value	1.87187e-05 (rank : 33)	NC score	0.452728 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	2.44474e-05 (rank : 34)	NC score	0.451987 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX5_HUMAN
θ value	5.44631e-05 (rank : 35)	NC score	0.485912 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	5.44631e-05 (rank : 36)	NC score	0.486501 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

IF4A1_HUMAN
θ value	0.00020696 (rank : 37)	NC score	0.435171 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	0.00020696 (rank : 38)	NC score	0.435171 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
θ value	0.00020696 (rank : 39)	NC score	0.436451 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	0.00020696 (rank : 40)	NC score	0.436451 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX3X_HUMAN
θ value	0.000786445 (rank : 41)	NC score	0.450148 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	0.000786445 (rank : 42)	NC score	0.451321 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	117	Shared Neighborhood Hits	73
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

PL10_MOUSE
θ value	0.00134147 (rank : 43)	NC score	0.448690 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	73
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX52_HUMAN
θ value	0.00228821 (rank : 44)	NC score	0.454750 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

SK2L2_HUMAN
θ value	0.00298849 (rank : 45)	NC score	0.137984 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

DDX3Y_HUMAN
θ value	0.00509761 (rank : 46)	NC score	0.448107 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	121	Shared Neighborhood Hits	73
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX52_MOUSE
θ value	0.00665767 (rank : 47)	NC score	0.453932 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

SK2L2_MOUSE
θ value	0.00665767 (rank : 48)	NC score	0.133889 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

DDX24_HUMAN
θ value	0.00869519 (rank : 49)	NC score	0.429340 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	190	Shared Neighborhood Hits	73
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
θ value	0.00869519 (rank : 50)	NC score	0.431140 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	147	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX31_HUMAN
θ value	0.0113563 (rank : 51)	NC score	0.429929 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX39_HUMAN
θ value	0.0113563 (rank : 52)	NC score	0.430069 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX1_MOUSE
θ value	0.0148317 (rank : 53)	NC score	0.413287 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX39_MOUSE
θ value	0.0148317 (rank : 54)	NC score	0.427357 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX3Y_MOUSE
θ value	0.0193708 (rank : 55)	NC score	0.442922 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX4_HUMAN
θ value	0.0193708 (rank : 56)	NC score	0.431947 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX1_HUMAN
θ value	0.0330416 (rank : 57)	NC score	0.409925 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	110	Shared Neighborhood Hits	71
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

UAP56_HUMAN
θ value	0.0330416 (rank : 58)	NC score	0.420479 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	0.0330416 (rank : 59)	NC score	0.420405 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX51_HUMAN
θ value	0.0431538 (rank : 60)	NC score	0.412557 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	332	Shared Neighborhood Hits	75
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

SKIV2_HUMAN
θ value	0.0431538 (rank : 61)	NC score	0.143147 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	45	Shared Neighborhood Hits	20
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

DDX54_HUMAN
θ value	0.0563607 (rank : 62)	NC score	0.423293 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX28_MOUSE
θ value	0.0961366 (rank : 63)	NC score	0.410869 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX51_MOUSE
θ value	0.0961366 (rank : 64)	NC score	0.410588 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	130	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX54_MOUSE
θ value	0.0961366 (rank : 65)	NC score	0.426739 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

U520_HUMAN
θ value	0.0961366 (rank : 66)	NC score	0.189869 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

DDX28_HUMAN
θ value	0.163984 (rank : 67)	NC score	0.397608 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	103	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX4_MOUSE
θ value	0.163984 (rank : 68)	NC score	0.430267 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DICER_MOUSE
θ value	0.47712 (rank : 69)	NC score	0.208175 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	140	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
θ value	0.62314 (rank : 70)	NC score	0.206005 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

VDP_HUMAN
θ value	0.62314 (rank : 71)	NC score	0.028083 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	645	Shared Neighborhood Hits	16
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

MACF1_MOUSE
θ value	0.813845 (rank : 72)	NC score	0.010600 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	1313	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

SDCG1_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.040493 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	O60524, Q8WW70, Q9NWG1	Gene names	SDCCAG1
Domain Architecture
Description	Serologically defined colon cancer antigen 1 (Antigen NY-CO-1).

ZN365_MOUSE
θ value	0.813845 (rank : 74)	NC score	0.033596 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG89, Q80TQ4, Q8BK39, Q8BXT2	Gene names	Znf365, Kiaa0844, Zfp365
Domain Architecture	No domain graphic available
Description	Protein ZNF365 (Su48).

TACC3_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.012876 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	779	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

LGP2_HUMAN
θ value	1.38821 (rank : 76)	NC score	0.179384 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	65
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

TPM1_MOUSE
θ value	1.38821 (rank : 77)	NC score	0.009892 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

IFIH1_MOUSE
θ value	1.81305 (rank : 78)	NC score	0.172933 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

TPM1_HUMAN
θ value	1.81305 (rank : 79)	NC score	0.009689 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	716	Shared Neighborhood Hits	13
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

DDX20_HUMAN
θ value	2.36792 (rank : 80)	NC score	0.393442 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	121	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

PKCB1_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.014353 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	488	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

PROF2_HUMAN
θ value	2.36792 (rank : 82)	NC score	0.023560 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P35080, Q8WVF9, Q9HBK2	Gene names	PFN2
Domain Architecture
Description	Profilin-2 (Profilin II).

ZN365_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.029308 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	Q70YC5, O94930, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7	Gene names	ZNF365, KIAA0844
Domain Architecture	No domain graphic available
Description	Protein ZNF365.

HELC1_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.150190 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

IFIH1_HUMAN
θ value	3.0926 (rank : 85)	NC score	0.175078 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

MACF1_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.009760 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	1341	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF4_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.011495 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	1321	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

PROF2_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.022397 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJV2, Q9ES49, Q9ES50	Gene names	Pfn2
Domain Architecture
Description	Profilin-2 (Profilin II).

SDCG1_MOUSE
θ value	3.0926 (rank : 89)	NC score	0.032602 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CCP0, Q66JX6, Q8C9R6, Q8CA65, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9	Gene names	Sdccag1
Domain Architecture
Description	Serologically defined colon cancer antigen 1.

CP250_MOUSE
θ value	4.03905 (rank : 90)	NC score	0.003364 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	1583	Shared Neighborhood Hits	15
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

DDX20_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.389293 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX55_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.379342 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

FA61A_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.016363 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q8ND56, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3	Gene names	FAM61A, C19orf13
Domain Architecture	No domain graphic available
Description	Protein FAM61A (Putative alpha synuclein-binding protein) (AlphaSNBP).

FA61A_MOUSE
θ value	5.27518 (rank : 94)	NC score	0.016220 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

FINC_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.003030 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	309	Shared Neighborhood Hits	2
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

K0562_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.009722 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	3
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

LGP2_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.170800 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

VDP_MOUSE
θ value	6.88961 (rank : 98)	NC score	0.030597 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	469	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

CCD21_MOUSE
θ value	8.99809 (rank : 99)	NC score	0.002995 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

NUF2_MOUSE
θ value	8.99809 (rank : 100)	NC score	0.004278 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	585	Shared Neighborhood Hits	12
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

CC026_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.066351 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

DD19A_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.364654 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.363352 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.363797 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	109	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX18_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.387315 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.379062 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	115	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX25_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.361633 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.358187 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX55_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.375998 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	122	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX56_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.356187 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.356742 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX58_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.084626 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	50
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.098010 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	50
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

EXDL2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.072924 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVH0, Q8N3D3	Gene names	EXDL2, C14orf114
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

EXDL2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.070633 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

FANCM_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.185596 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	210	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.184901 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

Hits sorted by NC score

RECQ1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
NC score	0.995067 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

BLM_MOUSE
NC score	0.924977 (rank : 3)	θ value	1.94503e-103 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	66
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.921464 (rank : 4)	θ value	2.15048e-102 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	148	Shared Neighborhood Hits	67
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

WRN_HUMAN
NC score	0.873212 (rank : 5)	θ value	9.43692e-66 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ5_HUMAN
NC score	0.867517 (rank : 6)	θ value	4.22625e-74 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	390	Shared Neighborhood Hits	68
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

WRN_MOUSE
NC score	0.850749 (rank : 7)	θ value	8.83269e-64 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	295	Shared Neighborhood Hits	76
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ4_HUMAN
NC score	0.838152 (rank : 8)	θ value	4.2656e-42 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	78
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.827957 (rank : 9)	θ value	5.57106e-42 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	206	Shared Neighborhood Hits	78
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

DDX17_MOUSE
NC score	0.491039 (rank : 10)	θ value	1.17247e-07 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	73
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.490964 (rank : 11)	θ value	1.17247e-07 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	104	Shared Neighborhood Hits	73
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX5_MOUSE
NC score	0.486501 (rank : 12)	θ value	5.44631e-05 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	73
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX5_HUMAN
NC score	0.485912 (rank : 13)	θ value	5.44631e-05 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX50_HUMAN
NC score	0.478902 (rank : 14)	θ value	2.21117e-06 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	74
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_MOUSE
NC score	0.478035 (rank : 15)	θ value	2.88788e-06 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	137	Shared Neighborhood Hits	74
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX46_HUMAN
NC score	0.477536 (rank : 16)	θ value	1.29631e-06 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	357	Shared Neighborhood Hits	75
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.476831 (rank : 17)	θ value	1.29631e-06 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	358	Shared Neighborhood Hits	75
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX43_HUMAN
NC score	0.476080 (rank : 18)	θ value	9.92553e-07 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX21_HUMAN
NC score	0.471221 (rank : 19)	θ value	1.17247e-07 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	308	Shared Neighborhood Hits	76
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX41_HUMAN
NC score	0.468412 (rank : 20)	θ value	1.09739e-05 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX6_HUMAN
NC score	0.467106 (rank : 21)	θ value	4.92598e-06 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	77
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.466962 (rank : 22)	θ value	4.92598e-06 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX41_MOUSE
NC score	0.466433 (rank : 23)	θ value	1.09739e-05 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	115	Shared Neighborhood Hits	74
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX21_MOUSE
NC score	0.463883 (rank : 24)	θ value	8.97725e-08 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX49_MOUSE
NC score	0.463049 (rank : 25)	θ value	6.87365e-08 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	119	Shared Neighborhood Hits	75
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_HUMAN
NC score	0.460151 (rank : 26)	θ value	7.59969e-07 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	223	Shared Neighborhood Hits	75
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX23_HUMAN
NC score	0.459817 (rank : 27)	θ value	2.21117e-06 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	486	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX52_HUMAN
NC score	0.454750 (rank : 28)	θ value	0.00228821 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
NC score	0.453932 (rank : 29)	θ value	0.00665767 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX47_HUMAN
NC score	0.452728 (rank : 30)	θ value	1.87187e-05 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
NC score	0.451987 (rank : 31)	θ value	2.44474e-05 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX3X_MOUSE
NC score	0.451321 (rank : 32)	θ value	0.000786445 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	117	Shared Neighborhood Hits	73
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX53_HUMAN
NC score	0.451268 (rank : 33)	θ value	9.92553e-07 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	70
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX48_HUMAN
NC score	0.450384 (rank : 34)	θ value	1.43324e-05 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX3X_HUMAN
NC score	0.450148 (rank : 35)	θ value	0.000786445 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX48_MOUSE
NC score	0.450143 (rank : 36)	θ value	1.43324e-05 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

PL10_MOUSE
NC score	0.448690 (rank : 37)	θ value	0.00134147 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	120	Shared Neighborhood Hits	73
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3Y_HUMAN
NC score	0.448107 (rank : 38)	θ value	0.00509761 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	121	Shared Neighborhood Hits	73
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX27_MOUSE
NC score	0.446168 (rank : 39)	θ value	1.09739e-05 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_HUMAN
NC score	0.444265 (rank : 40)	θ value	1.43324e-05 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	197	Shared Neighborhood Hits	73
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX3Y_MOUSE
NC score	0.442922 (rank : 41)	θ value	0.0193708 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	74
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

IF4A2_HUMAN
NC score	0.436451 (rank : 42)	θ value	0.00020696 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.436451 (rank : 43)	θ value	0.00020696 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	73
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A1_HUMAN
NC score	0.435171 (rank : 44)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.435171 (rank : 45)	θ value	0.00020696 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	73
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX10_HUMAN
NC score	0.434668 (rank : 46)	θ value	1.29631e-06 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	210	Shared Neighborhood Hits	72
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
NC score	0.432554 (rank : 47)	θ value	2.61198e-07 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	233	Shared Neighborhood Hits	70
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX4_HUMAN
NC score	0.431947 (rank : 48)	θ value	0.0193708 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX24_MOUSE
NC score	0.431140 (rank : 49)	θ value	0.00869519 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	147	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX4_MOUSE
NC score	0.430267 (rank : 50)	θ value	0.163984 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	75
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX39_HUMAN
NC score	0.430069 (rank : 51)	θ value	0.0113563 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	73
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX31_HUMAN
NC score	0.429929 (rank : 52)	θ value	0.0113563 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	132	Shared Neighborhood Hits	75
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX24_HUMAN
NC score	0.429340 (rank : 53)	θ value	0.00869519 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	190	Shared Neighborhood Hits	73
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX39_MOUSE
NC score	0.427357 (rank : 54)	θ value	0.0148317 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	73
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX54_MOUSE
NC score	0.426739 (rank : 55)	θ value	0.0961366 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	77
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX54_HUMAN
NC score	0.423293 (rank : 56)	θ value	0.0563607 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

UAP56_HUMAN
NC score	0.420479 (rank : 57)	θ value	0.0330416 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.420405 (rank : 58)	θ value	0.0330416 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX1_MOUSE
NC score	0.413287 (rank : 59)	θ value	0.0148317 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX51_HUMAN
NC score	0.412557 (rank : 60)	θ value	0.0431538 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	332	Shared Neighborhood Hits	75
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX28_MOUSE
NC score	0.410869 (rank : 61)	θ value	0.0961366 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	75
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX51_MOUSE
NC score	0.410588 (rank : 62)	θ value	0.0961366 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	130	Shared Neighborhood Hits	75
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_HUMAN
NC score	0.409925 (rank : 63)	θ value	0.0330416 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	110	Shared Neighborhood Hits	71
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX28_HUMAN
NC score	0.397608 (rank : 64)	θ value	0.163984 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	103	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX20_HUMAN
NC score	0.393442 (rank : 65)	θ value	2.36792 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	121	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
NC score	0.389293 (rank : 66)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	71
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX18_HUMAN
NC score	0.387315 (rank : 67)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	124	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX55_MOUSE
NC score	0.379342 (rank : 68)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX18_MOUSE
NC score	0.379062 (rank : 69)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	115	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX55_HUMAN
NC score	0.375998 (rank : 70)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	122	Shared Neighborhood Hits	71
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DD19A_HUMAN
NC score	0.364654 (rank : 71)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
NC score	0.363797 (rank : 72)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	109	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_MOUSE
NC score	0.363352 (rank : 73)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX25_HUMAN
NC score	0.361633 (rank : 74)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	93	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
NC score	0.358187 (rank : 75)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX56_MOUSE
NC score	0.356742 (rank : 76)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX56_HUMAN
NC score	0.356187 (rank : 77)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DICER_MOUSE
NC score	0.208175 (rank : 78)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	140	Shared Neighborhood Hits	72
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
NC score	0.206005 (rank : 79)	θ value	0.62314 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

U520_HUMAN
NC score	0.189869 (rank : 80)	θ value	0.0961366 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	43
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

FANCM_HUMAN
NC score	0.185596 (rank : 81)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	210	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.184901 (rank : 82)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	177	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

LGP2_HUMAN
NC score	0.179384 (rank : 83)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	65
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

IFIH1_HUMAN
NC score	0.175078 (rank : 84)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	96	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

IFIH1_MOUSE
NC score	0.172933 (rank : 85)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	126	Shared Neighborhood Hits	71
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_MOUSE
NC score	0.170800 (rank : 86)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	62
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

HELC1_HUMAN
NC score	0.150190 (rank : 87)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	36
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SKIV2_HUMAN
NC score	0.143147 (rank : 88)	θ value	0.0431538 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	45	Shared Neighborhood Hits	20
SwissProt Accessions	Q15477, O15005, Q12902, Q15476	Gene names	SKIV2L, DDX13, SKI2W, SKIV2, W
Domain Architecture
Description	Helicase SKI2W (EC 3.6.1.-) (Helicase-like protein) (HLP).

SK2L2_HUMAN
NC score	0.137984 (rank : 89)	θ value	0.00298849 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	P42285, Q8TAG2	Gene names	SKIV2L2, KIAA0052
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

SK2L2_MOUSE
NC score	0.133889 (rank : 90)	θ value	0.00665767 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	45	Shared Neighborhood Hits	16
SwissProt Accessions	Q9CZU3	Gene names	Skiv2l2
Domain Architecture	No domain graphic available
Description	Superkiller viralicidic activity 2-like 2 (EC 3.6.1.-) (ATP-dependent helicase SKIV2L2).

DDX58_MOUSE
NC score	0.098010 (rank : 91)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	50
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_HUMAN
NC score	0.084626 (rank : 92)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	50
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

EXDL2_HUMAN
NC score	0.072924 (rank : 93)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NVH0, Q8N3D3	Gene names	EXDL2, C14orf114
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

EXDL2_MOUSE
NC score	0.070633 (rank : 94)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEG4	Gene names	Exdl2
Domain Architecture
Description	Exonuclease 3'-5' domain-like-containing protein 2.

CC026_HUMAN
NC score	0.066351 (rank : 95)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

SDCG1_HUMAN
NC score	0.040493 (rank : 96)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	190	Shared Neighborhood Hits	5
SwissProt Accessions	O60524, Q8WW70, Q9NWG1	Gene names	SDCCAG1
Domain Architecture
Description	Serologically defined colon cancer antigen 1 (Antigen NY-CO-1).

ZN365_MOUSE
NC score	0.033596 (rank : 97)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	193	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BG89, Q80TQ4, Q8BK39, Q8BXT2	Gene names	Znf365, Kiaa0844, Zfp365
Domain Architecture	No domain graphic available
Description	Protein ZNF365 (Su48).

SDCG1_MOUSE
NC score	0.032602 (rank : 98)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CCP0, Q66JX6, Q8C9R6, Q8CA65, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9	Gene names	Sdccag1
Domain Architecture
Description	Serologically defined colon cancer antigen 1.

VDP_MOUSE
NC score	0.030597 (rank : 99)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	469	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

ZN365_HUMAN
NC score	0.029308 (rank : 100)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	145	Shared Neighborhood Hits	6
SwissProt Accessions	Q70YC5, O94930, Q5HYE6, Q68SG8, Q6NSK2, Q6P9D4, Q70YC6, Q70YC7	Gene names	ZNF365, KIAA0844
Domain Architecture	No domain graphic available
Description	Protein ZNF365.

VDP_HUMAN
NC score	0.028083 (rank : 101)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	645	Shared Neighborhood Hits	16
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

PROF2_HUMAN
NC score	0.023560 (rank : 102)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	P35080, Q8WVF9, Q9HBK2	Gene names	PFN2
Domain Architecture
Description	Profilin-2 (Profilin II).

PROF2_MOUSE
NC score	0.022397 (rank : 103)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JJV2, Q9ES49, Q9ES50	Gene names	Pfn2
Domain Architecture
Description	Profilin-2 (Profilin II).

FA61A_HUMAN
NC score	0.016363 (rank : 104)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q8ND56, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3	Gene names	FAM61A, C19orf13
Domain Architecture	No domain graphic available
Description	Protein FAM61A (Putative alpha synuclein-binding protein) (AlphaSNBP).

FA61A_MOUSE
NC score	0.016220 (rank : 105)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	81	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2F8, Q9CTG8	Gene names	Fam61a
Domain Architecture	No domain graphic available
Description	Protein FAM61A.

PKCB1_HUMAN
NC score	0.014353 (rank : 106)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	488	Shared Neighborhood Hits	5
SwissProt Accessions	Q9ULU4, Q13517, Q4JJ94, Q4JJ95, Q5TH09, Q6MZM1, Q8WXC5, Q9H1F3, Q9H1F4, Q9H1F5, Q9H1L8, Q9H1L9, Q9H2G5, Q9NYN3, Q9UIX6	Gene names	PRKCBP1, KIAA1125, RACK7, ZMYND8
Domain Architecture
Description	Protein kinase C-binding protein 1 (Rack7) (Cutaneous T-cell lymphoma- associated antigen se14-3) (CTCL tumor antigen se14-3) (Zinc finger MYND domain-containing protein 8).

TACC3_HUMAN
NC score	0.012876 (rank : 107)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	779	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

MACF4_HUMAN
NC score	0.011495 (rank : 108)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	1321	Shared Neighborhood Hits	16
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MACF1_MOUSE
NC score	0.010600 (rank : 109)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	1313	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

TPM1_MOUSE
NC score	0.009892 (rank : 110)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	729	Shared Neighborhood Hits	13
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

MACF1_HUMAN
NC score	0.009760 (rank : 111)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	1341	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

K0562_HUMAN
NC score	0.009722 (rank : 112)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	3
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

TPM1_HUMAN
NC score	0.009689 (rank : 113)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	716	Shared Neighborhood Hits	13
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

NUF2_MOUSE
NC score	0.004278 (rank : 114)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	585	Shared Neighborhood Hits	12
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

CP250_MOUSE
NC score	0.003364 (rank : 115)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	1583	Shared Neighborhood Hits	15
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

FINC_MOUSE
NC score	0.003030 (rank : 116)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	309	Shared Neighborhood Hits	2
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

CCD21_MOUSE
NC score	0.002995 (rank : 117)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	1135	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.