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Network neighborhood for query Sequence : DD19B_HUMAN

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DD19B_HUMAN
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DD19A_HUMAN
θ value	0 (rank : 1)	NC score	0.999688 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
θ value	0 (rank : 2)	NC score	0.999612 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	101
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DD19B_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DDX25_MOUSE
θ value	1.07914e-178 (rank : 4)	NC score	0.996407 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
θ value	9.13544e-178 (rank : 5)	NC score	0.996633 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	93	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

IF4A2_HUMAN
θ value	7.97034e-73 (rank : 6)	NC score	0.971643 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	86
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	7.97034e-73 (rank : 7)	NC score	0.971643 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	86
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A1_HUMAN
θ value	2.31901e-72 (rank : 8)	NC score	0.971672 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	2.31901e-72 (rank : 9)	NC score	0.971672 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX48_HUMAN
θ value	3.83135e-67 (rank : 10)	NC score	0.969836 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	5.00389e-67 (rank : 11)	NC score	0.969750 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

UAP56_HUMAN
θ value	1.66964e-54 (rank : 12)	NC score	0.959756 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	1.66964e-54 (rank : 13)	NC score	0.959734 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX39_HUMAN
θ value	1.41344e-53 (rank : 14)	NC score	0.959748 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	86
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
θ value	2.41096e-53 (rank : 15)	NC score	0.959629 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX6_HUMAN
θ value	4.54686e-52 (rank : 16)	NC score	0.961104 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	83
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	4.54686e-52 (rank : 17)	NC score	0.960869 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	98	Shared Neighborhood Hits	83
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX20_HUMAN
θ value	3.2585e-50 (rank : 18)	NC score	0.955182 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
θ value	8.02596e-49 (rank : 19)	NC score	0.951669 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX47_HUMAN
θ value	2.76489e-41 (rank : 20)	NC score	0.941517 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	1.05066e-40 (rank : 21)	NC score	0.941953 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX27_HUMAN
θ value	2.58786e-39 (rank : 22)	NC score	0.935995 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	197	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX3X_MOUSE
θ value	1.42001e-37 (rank : 23)	NC score	0.917957 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3X_HUMAN
θ value	1.85459e-37 (rank : 24)	NC score	0.918072 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3Y_HUMAN
θ value	1.85459e-37 (rank : 25)	NC score	0.917928 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	87
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX27_MOUSE
θ value	3.16345e-37 (rank : 26)	NC score	0.936841 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	174	Shared Neighborhood Hits	86
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

PL10_MOUSE
θ value	3.16345e-37 (rank : 27)	NC score	0.918301 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX49_HUMAN
θ value	1.73584e-35 (rank : 28)	NC score	0.931573 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	223	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX3Y_MOUSE
θ value	2.26708e-35 (rank : 29)	NC score	0.916609 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX56_MOUSE
θ value	5.0505e-35 (rank : 30)	NC score	0.938146 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX49_MOUSE
θ value	1.12514e-34 (rank : 31)	NC score	0.935304 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX52_HUMAN
θ value	1.46948e-34 (rank : 32)	NC score	0.935346 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX56_HUMAN
θ value	3.27365e-34 (rank : 33)	NC score	0.937067 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX23_HUMAN
θ value	6.17384e-33 (rank : 34)	NC score	0.899700 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	486	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX52_MOUSE
θ value	6.17384e-33 (rank : 35)	NC score	0.933119 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	101	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX4_HUMAN
θ value	8.06329e-33 (rank : 36)	NC score	0.922875 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX43_HUMAN
θ value	1.79631e-32 (rank : 37)	NC score	0.924013 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	120	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX4_MOUSE
θ value	3.06405e-32 (rank : 38)	NC score	0.923883 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX54_MOUSE
θ value	3.06405e-32 (rank : 39)	NC score	0.929068 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX54_HUMAN
θ value	1.16434e-31 (rank : 40)	NC score	0.925442 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX17_HUMAN
θ value	4.42448e-31 (rank : 41)	NC score	0.916118 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	104	Shared Neighborhood Hits	83
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	4.42448e-31 (rank : 42)	NC score	0.916258 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	83
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX46_HUMAN
θ value	1.28732e-30 (rank : 43)	NC score	0.902557 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	357	Shared Neighborhood Hits	86
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	1.28732e-30 (rank : 44)	NC score	0.900471 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	358	Shared Neighborhood Hits	86
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX41_HUMAN
θ value	2.19584e-30 (rank : 45)	NC score	0.923835 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX21_HUMAN
θ value	2.86786e-30 (rank : 46)	NC score	0.903502 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX41_MOUSE
θ value	6.38894e-30 (rank : 47)	NC score	0.923063 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	91
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX5_HUMAN
θ value	3.17079e-29 (rank : 48)	NC score	0.912182 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	83
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX21_MOUSE
θ value	4.14116e-29 (rank : 49)	NC score	0.895295 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX5_MOUSE
θ value	7.06379e-29 (rank : 50)	NC score	0.911992 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	101	Shared Neighborhood Hits	83
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX50_MOUSE
θ value	3.50572e-28 (rank : 51)	NC score	0.912039 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	137	Shared Neighborhood Hits	85
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX18_MOUSE
θ value	5.97985e-28 (rank : 52)	NC score	0.915342 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX50_HUMAN
θ value	5.97985e-28 (rank : 53)	NC score	0.911702 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX10_MOUSE
θ value	1.33217e-27 (rank : 54)	NC score	0.906707 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	233	Shared Neighborhood Hits	80
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX18_HUMAN
θ value	1.73987e-27 (rank : 55)	NC score	0.911773 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX55_HUMAN
θ value	1.73987e-27 (rank : 56)	NC score	0.917639 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX10_HUMAN
θ value	2.27234e-27 (rank : 57)	NC score	0.905987 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	210	Shared Neighborhood Hits	80
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX53_HUMAN
θ value	3.87602e-27 (rank : 58)	NC score	0.917874 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	80
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX1_MOUSE
θ value	3.28125e-26 (rank : 59)	NC score	0.880524 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX55_MOUSE
θ value	4.28545e-26 (rank : 60)	NC score	0.916808 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	82
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX28_HUMAN
θ value	1.24688e-25 (rank : 61)	NC score	0.925074 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX1_HUMAN
θ value	4.73814e-25 (rank : 62)	NC score	0.878031 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	110	Shared Neighborhood Hits	81
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX28_MOUSE
θ value	5.23862e-24 (rank : 63)	NC score	0.925568 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX31_HUMAN
θ value	9.24701e-21 (rank : 64)	NC score	0.895018 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX51_MOUSE
θ value	1.2077e-20 (rank : 65)	NC score	0.898208 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	130	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX51_HUMAN
θ value	2.69047e-20 (rank : 66)	NC score	0.880571 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	332	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX24_MOUSE
θ value	3.63628e-17 (rank : 67)	NC score	0.885516 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_HUMAN
θ value	4.02038e-16 (rank : 68)	NC score	0.880638 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	84
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

LGP2_MOUSE
θ value	0.00102713 (rank : 69)	NC score	0.344601 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

WRN_MOUSE
θ value	0.00102713 (rank : 70)	NC score	0.407651 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	295	Shared Neighborhood Hits	76
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

RECQ5_HUMAN
θ value	0.00228821 (rank : 71)	NC score	0.422333 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

FANCM_HUMAN
θ value	0.00298849 (rank : 72)	NC score	0.421461 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	210	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

IFIH1_HUMAN
θ value	0.00509761 (rank : 73)	NC score	0.341266 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

RECQ4_HUMAN
θ value	0.0148317 (rank : 74)	NC score	0.503574 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
θ value	0.0148317 (rank : 75)	NC score	0.488565 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	206	Shared Neighborhood Hits	81
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

WRN_HUMAN
θ value	0.0148317 (rank : 76)	NC score	0.430021 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	76
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

FANCM_MOUSE
θ value	0.0431538 (rank : 77)	NC score	0.414203 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

IFIH1_MOUSE
θ value	0.0431538 (rank : 78)	NC score	0.319829 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

DICER_MOUSE
θ value	0.0563607 (rank : 79)	NC score	0.390350 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	140	Shared Neighborhood Hits	78
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

DICER_HUMAN
θ value	0.0736092 (rank : 80)	NC score	0.391725 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

BLM_MOUSE
θ value	0.125558 (rank : 81)	NC score	0.442077 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

LGP2_HUMAN
θ value	0.163984 (rank : 82)	NC score	0.319200 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	69
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

SMRCD_MOUSE
θ value	0.279714 (rank : 83)	NC score	0.040054 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	21
SwissProt Accessions	Q04692	Gene names	Smarcad1, Etl1, Kiaa1122
Domain Architecture
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.1.-) (ATP- dependent helicase SMARCAD1) (Enhancer trap locus homolog 1) (Etl-1).

BLM_HUMAN
θ value	0.365318 (rank : 84)	NC score	0.428368 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	71
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

SMRCD_HUMAN
θ value	0.365318 (rank : 85)	NC score	0.038449 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4L7, Q96SX1, Q9H017, Q9H860, Q9NPU9, Q9ULU7	Gene names	SMARCAD1, KIAA1122
Domain Architecture
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.1.-) (ATP- dependent helicase 1) (hHEL1).

BTAF1_HUMAN
θ value	0.47712 (rank : 86)	NC score	0.030645 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	17
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

CHD3_HUMAN
θ value	1.06291 (rank : 87)	NC score	0.047067 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	397	Shared Neighborhood Hits	30
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD4_HUMAN
θ value	1.06291 (rank : 88)	NC score	0.053668 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	365	Shared Neighborhood Hits	33
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.053275 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	408	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

LAMB1_MOUSE
θ value	1.06291 (rank : 90)	NC score	-0.000192 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	919	Shared Neighborhood Hits	9
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

JAD1D_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.005468 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	147	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

SMCA4_HUMAN
θ value	1.81305 (rank : 92)	NC score	0.031457 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	597	Shared Neighborhood Hits	26
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

PININ_MOUSE
θ value	2.36792 (rank : 93)	NC score	0.006307 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	777	Shared Neighborhood Hits	13
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

ARHG2_HUMAN
θ value	3.0926 (rank : 94)	NC score	0.007680 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CHD1_HUMAN
θ value	4.03905 (rank : 95)	NC score	0.040918 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	337	Shared Neighborhood Hits	32
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CHD1_MOUSE
θ value	4.03905 (rank : 96)	NC score	0.041077 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

EEA1_MOUSE
θ value	4.03905 (rank : 97)	NC score	-0.002747 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	1637	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SMCA2_HUMAN
θ value	4.03905 (rank : 98)	NC score	0.028918 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	503	Shared Neighborhood Hits	25
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SYNE1_HUMAN
θ value	4.03905 (rank : 99)	NC score	-0.001472 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	1484	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

KINH_HUMAN
θ value	5.27518 (rank : 100)	NC score	0.001802 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	1231	Shared Neighborhood Hits	18
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

SPC25_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.010231 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	273	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

CTR9_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.004520 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	383	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

CTR9_MOUSE
θ value	6.88961 (rank : 103)	NC score	0.004847 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	427	Shared Neighborhood Hits	8
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

DHX33_HUMAN
θ value	6.88961 (rank : 104)	NC score	0.012502 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	40	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H6R0, Q4G149, Q5CZ73, Q9H5M9	Gene names	DHX33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

DHX33_MOUSE
θ value	6.88961 (rank : 105)	NC score	0.013805 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

KINH_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.002007 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	1082	Shared Neighborhood Hits	16
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

CHD2_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.031844 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	360	Shared Neighborhood Hits	31
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

RAB17_MOUSE
θ value	8.99809 (rank : 108)	NC score	-0.002021 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35292, Q921D2, Q9D723	Gene names	Rab17
Domain Architecture
Description	Ras-related protein Rab-17.

TEKT1_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.000706 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	399	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

CC026_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.163587 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

CC026_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.130947 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

DDX58_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.161397 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.192509 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

HELC1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.085723 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

RECQ1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.363797 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.361463 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

SMAL1_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.075131 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SMAL1_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.055566 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

SMCA1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.057236 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

U520_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.105572 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

Hits sorted by NC score

DD19B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_HUMAN
NC score	0.999688 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	102
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19A_MOUSE
NC score	0.999612 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	101
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX25_HUMAN
NC score	0.996633 (rank : 4)	θ value	9.13544e-178 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	93	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
NC score	0.996407 (rank : 5)	θ value	1.07914e-178 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	98	Shared Neighborhood Hits	89
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

IF4A1_HUMAN
NC score	0.971672 (rank : 6)	θ value	2.31901e-72 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.971672 (rank : 7)	θ value	2.31901e-72 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	86
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
NC score	0.971643 (rank : 8)	θ value	7.97034e-73 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	86
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.971643 (rank : 9)	θ value	7.97034e-73 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	86
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX48_HUMAN
NC score	0.969836 (rank : 10)	θ value	3.83135e-67 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.969750 (rank : 11)	θ value	5.00389e-67 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX6_HUMAN
NC score	0.961104 (rank : 12)	θ value	4.54686e-52 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	83
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.960869 (rank : 13)	θ value	4.54686e-52 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	98	Shared Neighborhood Hits	83
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

UAP56_HUMAN
NC score	0.959756 (rank : 14)	θ value	1.66964e-54 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

DDX39_HUMAN
NC score	0.959748 (rank : 15)	θ value	1.41344e-53 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	86
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

UAP56_MOUSE
NC score	0.959734 (rank : 16)	θ value	1.66964e-54 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX39_MOUSE
NC score	0.959629 (rank : 17)	θ value	2.41096e-53 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX20_HUMAN
NC score	0.955182 (rank : 18)	θ value	3.2585e-50 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX20_MOUSE
NC score	0.951669 (rank : 19)	θ value	8.02596e-49 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	86
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX47_MOUSE
NC score	0.941953 (rank : 20)	θ value	1.05066e-40 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_HUMAN
NC score	0.941517 (rank : 21)	θ value	2.76489e-41 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX56_MOUSE
NC score	0.938146 (rank : 22)	θ value	5.0505e-35 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX56_HUMAN
NC score	0.937067 (rank : 23)	θ value	3.27365e-34 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX27_MOUSE
NC score	0.936841 (rank : 24)	θ value	3.16345e-37 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	174	Shared Neighborhood Hits	86
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX27_HUMAN
NC score	0.935995 (rank : 25)	θ value	2.58786e-39 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	197	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX52_HUMAN
NC score	0.935346 (rank : 26)	θ value	1.46948e-34 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	83
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX49_MOUSE
NC score	0.935304 (rank : 27)	θ value	1.12514e-34 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	87
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX52_MOUSE
NC score	0.933119 (rank : 28)	θ value	6.17384e-33 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	101	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX49_HUMAN
NC score	0.931573 (rank : 29)	θ value	1.73584e-35 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	223	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX54_MOUSE
NC score	0.929068 (rank : 30)	θ value	3.06405e-32 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX28_MOUSE
NC score	0.925568 (rank : 31)	θ value	5.23862e-24 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	87
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX54_HUMAN
NC score	0.925442 (rank : 32)	θ value	1.16434e-31 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	81
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX28_HUMAN
NC score	0.925074 (rank : 33)	θ value	1.24688e-25 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX43_HUMAN
NC score	0.924013 (rank : 34)	θ value	1.79631e-32 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	120	Shared Neighborhood Hits	83
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX4_MOUSE
NC score	0.923883 (rank : 35)	θ value	3.06405e-32 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	86
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX41_HUMAN
NC score	0.923835 (rank : 36)	θ value	2.19584e-30 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	91
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
NC score	0.923063 (rank : 37)	θ value	6.38894e-30 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	91
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX4_HUMAN
NC score	0.922875 (rank : 38)	θ value	8.06329e-33 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

PL10_MOUSE
NC score	0.918301 (rank : 39)	θ value	3.16345e-37 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_HUMAN
NC score	0.918072 (rank : 40)	θ value	1.85459e-37 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	122	Shared Neighborhood Hits	87
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
NC score	0.917957 (rank : 41)	θ value	1.42001e-37 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
NC score	0.917928 (rank : 42)	θ value	1.85459e-37 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	87
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX53_HUMAN
NC score	0.917874 (rank : 43)	θ value	3.87602e-27 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	80
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX55_HUMAN
NC score	0.917639 (rank : 44)	θ value	1.73987e-27 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
NC score	0.916808 (rank : 45)	θ value	4.28545e-26 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	82
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX3Y_MOUSE
NC score	0.916609 (rank : 46)	θ value	2.26708e-35 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX17_MOUSE
NC score	0.916258 (rank : 47)	θ value	4.42448e-31 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	83
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.916118 (rank : 48)	θ value	4.42448e-31 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	104	Shared Neighborhood Hits	83
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX18_MOUSE
NC score	0.915342 (rank : 49)	θ value	5.97985e-28 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX5_HUMAN
NC score	0.912182 (rank : 50)	θ value	3.17079e-29 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	102	Shared Neighborhood Hits	83
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX50_MOUSE
NC score	0.912039 (rank : 51)	θ value	3.50572e-28 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	137	Shared Neighborhood Hits	85
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX5_MOUSE
NC score	0.911992 (rank : 52)	θ value	7.06379e-29 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	101	Shared Neighborhood Hits	83
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX18_HUMAN
NC score	0.911773 (rank : 53)	θ value	1.73987e-27 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	124	Shared Neighborhood Hits	77
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX50_HUMAN
NC score	0.911702 (rank : 54)	θ value	5.97985e-28 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX10_MOUSE
NC score	0.906707 (rank : 55)	θ value	1.33217e-27 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	233	Shared Neighborhood Hits	80
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_HUMAN
NC score	0.905987 (rank : 56)	θ value	2.27234e-27 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	210	Shared Neighborhood Hits	80
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX21_HUMAN
NC score	0.903502 (rank : 57)	θ value	2.86786e-30 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	308	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX46_HUMAN
NC score	0.902557 (rank : 58)	θ value	1.28732e-30 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	357	Shared Neighborhood Hits	86
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.900471 (rank : 59)	θ value	1.28732e-30 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	358	Shared Neighborhood Hits	86
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX23_HUMAN
NC score	0.899700 (rank : 60)	θ value	6.17384e-33 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	486	Shared Neighborhood Hits	96
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX51_MOUSE
NC score	0.898208 (rank : 61)	θ value	1.2077e-20 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	130	Shared Neighborhood Hits	83
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX21_MOUSE
NC score	0.895295 (rank : 62)	θ value	4.14116e-29 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	350	Shared Neighborhood Hits	85
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX31_HUMAN
NC score	0.895018 (rank : 63)	θ value	9.24701e-21 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	85
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX24_MOUSE
NC score	0.885516 (rank : 64)	θ value	3.63628e-17 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	147	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_HUMAN
NC score	0.880638 (rank : 65)	θ value	4.02038e-16 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	84
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX51_HUMAN
NC score	0.880571 (rank : 66)	θ value	2.69047e-20 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	332	Shared Neighborhood Hits	86
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX1_MOUSE
NC score	0.880524 (rank : 67)	θ value	3.28125e-26 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	112	Shared Neighborhood Hits	81
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.878031 (rank : 68)	θ value	4.73814e-25 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	110	Shared Neighborhood Hits	81
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

RECQ4_HUMAN
NC score	0.503574 (rank : 69)	θ value	0.0148317 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	83
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.488565 (rank : 70)	θ value	0.0148317 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	206	Shared Neighborhood Hits	81
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

BLM_MOUSE
NC score	0.442077 (rank : 71)	θ value	0.125558 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	108	Shared Neighborhood Hits	68
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

WRN_HUMAN
NC score	0.430021 (rank : 72)	θ value	0.0148317 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	76
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

BLM_HUMAN
NC score	0.428368 (rank : 73)	θ value	0.365318 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	71
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

RECQ5_HUMAN
NC score	0.422333 (rank : 74)	θ value	0.00228821 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	390	Shared Neighborhood Hits	77
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

FANCM_HUMAN
NC score	0.421461 (rank : 75)	θ value	0.00298849 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	210	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.414203 (rank : 76)	θ value	0.0431538 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	177	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

WRN_MOUSE
NC score	0.407651 (rank : 77)	θ value	0.00102713 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	295	Shared Neighborhood Hits	76
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

DICER_HUMAN
NC score	0.391725 (rank : 78)	θ value	0.0736092 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.390350 (rank : 79)	θ value	0.0563607 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	140	Shared Neighborhood Hits	78
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

RECQ1_HUMAN
NC score	0.363797 (rank : 80)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	71
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ1_MOUSE
NC score	0.361463 (rank : 81)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

LGP2_MOUSE
NC score	0.344601 (rank : 82)	θ value	0.00102713 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_HUMAN
NC score	0.341266 (rank : 83)	θ value	0.00509761 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

IFIH1_MOUSE
NC score	0.319829 (rank : 84)	θ value	0.0431538 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	126	Shared Neighborhood Hits	77
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
NC score	0.319200 (rank : 85)	θ value	0.163984 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	69
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DDX58_MOUSE
NC score	0.192509 (rank : 86)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_HUMAN
NC score	0.163587 (rank : 87)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	39	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

DDX58_HUMAN
NC score	0.161397 (rank : 88)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_MOUSE
NC score	0.130947 (rank : 89)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

U520_HUMAN
NC score	0.105572 (rank : 90)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	88	Shared Neighborhood Hits	40
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

HELC1_HUMAN
NC score	0.085723 (rank : 91)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
NC score	0.075131 (rank : 92)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

SMCA1_MOUSE
NC score	0.057236 (rank : 93)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PGB8, Q8BSS1, Q91Y58	Gene names	Smarca1, Snf2l
Domain Architecture	No domain graphic available
Description	Probable global transcription activator SNF2L1 (EC 3.6.1.-) (Nucleosome remodeling factor subunit SNF2L) (ATP-dependent helicase SMARCA1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) (DNA-dependent ATPase SNF2L).

SMAL1_MOUSE
NC score	0.055566 (rank : 94)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	157	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

CHD4_HUMAN
NC score	0.053668 (rank : 95)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	365	Shared Neighborhood Hits	33
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
NC score	0.053275 (rank : 96)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	408	Shared Neighborhood Hits	33
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

CHD3_HUMAN
NC score	0.047067 (rank : 97)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	397	Shared Neighborhood Hits	30
SwissProt Accessions	Q12873, Q9Y4I0	Gene names	CHD3
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 3 (EC 3.6.1.-) (ATP- dependent helicase CHD3) (CHD-3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc-finger helicase) (hZFH).

CHD1_MOUSE
NC score	0.041077 (rank : 98)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	266	Shared Neighborhood Hits	31
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CHD1_HUMAN
NC score	0.040918 (rank : 99)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	337	Shared Neighborhood Hits	32
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

SMRCD_MOUSE
NC score	0.040054 (rank : 100)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	21
SwissProt Accessions	Q04692	Gene names	Smarcad1, Etl1, Kiaa1122
Domain Architecture
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.1.-) (ATP- dependent helicase SMARCAD1) (Enhancer trap locus homolog 1) (Etl-1).

SMRCD_HUMAN
NC score	0.038449 (rank : 101)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	117	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H4L7, Q96SX1, Q9H017, Q9H860, Q9NPU9, Q9ULU7	Gene names	SMARCAD1, KIAA1122
Domain Architecture
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.1.-) (ATP- dependent helicase 1) (hHEL1).

CHD2_HUMAN
NC score	0.031844 (rank : 102)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	360	Shared Neighborhood Hits	31
SwissProt Accessions	O14647	Gene names	CHD2
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-) (ATP- dependent helicase CHD2) (CHD-2).

SMCA4_HUMAN
NC score	0.031457 (rank : 103)	θ value	1.81305 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	597	Shared Neighborhood Hits	26
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

BTAF1_HUMAN
NC score	0.030645 (rank : 104)	θ value	0.47712 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	97	Shared Neighborhood Hits	17
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

SMCA2_HUMAN
NC score	0.028918 (rank : 105)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	503	Shared Neighborhood Hits	25
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

DHX33_MOUSE
NC score	0.013805 (rank : 106)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q80VY9, Q8BS50	Gene names	Dhx33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

DHX33_HUMAN
NC score	0.012502 (rank : 107)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	40	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H6R0, Q4G149, Q5CZ73, Q9H5M9	Gene names	DHX33
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX33 (EC 3.6.1.-) (DEAH box protein 33).

SPC25_HUMAN
NC score	0.010231 (rank : 108)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	273	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

ARHG2_HUMAN
NC score	0.007680 (rank : 109)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	142	Shared Neighborhood Hits	4
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PININ_MOUSE
NC score	0.006307 (rank : 110)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	777	Shared Neighborhood Hits	13
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

JAD1D_HUMAN
NC score	0.005468 (rank : 111)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	147	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

CTR9_MOUSE
NC score	0.004847 (rank : 112)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	427	Shared Neighborhood Hits	8
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

CTR9_HUMAN
NC score	0.004520 (rank : 113)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	383	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PD62, Q15015	Gene names	CTR9, KIAA0155, SH2BP1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1).

KINH_MOUSE
NC score	0.002007 (rank : 114)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	1082	Shared Neighborhood Hits	16
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KINH_HUMAN
NC score	0.001802 (rank : 115)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	1231	Shared Neighborhood Hits	18
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

TEKT1_MOUSE
NC score	0.000706 (rank : 116)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	399	Shared Neighborhood Hits	10
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

LAMB1_MOUSE
NC score	-0.000192 (rank : 117)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	919	Shared Neighborhood Hits	9
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

SYNE1_HUMAN
NC score	-0.001472 (rank : 118)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	1484	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

RAB17_MOUSE
NC score	-0.002021 (rank : 119)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	277	Shared Neighborhood Hits	4
SwissProt Accessions	P35292, Q921D2, Q9D723	Gene names	Rab17
Domain Architecture
Description	Ras-related protein Rab-17.

EEA1_MOUSE
NC score	-0.002747 (rank : 120)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	1637	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.