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Network neighborhood for query Sequence : DDX24_HUMAN

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DDX24_HUMAN
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DDX24_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	190	Target Neighborhood Hits	190	Shared Neighborhood Hits	190
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
θ value	0 (rank : 2)	NC score	0.992652 (rank : 2)
Query Neighborhood Hits	190	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX47_HUMAN
θ value	3.72821e-46 (rank : 3)	NC score	0.949644 (rank : 4)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_MOUSE
θ value	8.30557e-46 (rank : 4)	NC score	0.949864 (rank : 3)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX49_HUMAN
θ value	1.79215e-40 (rank : 5)	NC score	0.943132 (rank : 6)
Query Neighborhood Hits	190	Target Neighborhood Hits	223	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_MOUSE
θ value	1.6774e-38 (rank : 6)	NC score	0.945605 (rank : 5)
Query Neighborhood Hits	190	Target Neighborhood Hits	119	Shared Neighborhood Hits	86
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX18_HUMAN
θ value	1.46948e-34 (rank : 7)	NC score	0.933609 (rank : 8)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
θ value	2.50655e-34 (rank : 8)	NC score	0.933474 (rank : 9)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX27_MOUSE
θ value	9.52487e-34 (rank : 9)	NC score	0.934666 (rank : 7)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	89
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX41_HUMAN
θ value	2.77131e-33 (rank : 10)	NC score	0.932960 (rank : 11)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX41_MOUSE
θ value	2.77131e-33 (rank : 11)	NC score	0.932641 (rank : 13)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX17_HUMAN
θ value	6.17384e-33 (rank : 12)	NC score	0.926165 (rank : 21)
Query Neighborhood Hits	190	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX17_MOUSE
θ value	6.17384e-33 (rank : 13)	NC score	0.926298 (rank : 20)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	84
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX27_HUMAN
θ value	6.17384e-33 (rank : 14)	NC score	0.932956 (rank : 12)
Query Neighborhood Hits	190	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX54_MOUSE
θ value	1.52067e-31 (rank : 15)	NC score	0.931930 (rank : 14)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX10_HUMAN
θ value	5.77852e-31 (rank : 16)	NC score	0.925860 (rank : 22)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	89
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
θ value	4.89182e-30 (rank : 17)	NC score	0.925287 (rank : 23)
Query Neighborhood Hits	190	Target Neighborhood Hits	233	Shared Neighborhood Hits	88
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX54_HUMAN
θ value	8.3442e-30 (rank : 18)	NC score	0.927540 (rank : 18)
Query Neighborhood Hits	190	Target Neighborhood Hits	170	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX55_HUMAN
θ value	1.08979e-29 (rank : 19)	NC score	0.931458 (rank : 15)
Query Neighborhood Hits	190	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX55_MOUSE
θ value	1.4233e-29 (rank : 20)	NC score	0.933048 (rank : 10)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX5_HUMAN
θ value	5.40856e-29 (rank : 21)	NC score	0.919632 (rank : 29)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
θ value	5.40856e-29 (rank : 22)	NC score	0.919611 (rank : 30)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX46_HUMAN
θ value	5.97985e-28 (rank : 23)	NC score	0.907071 (rank : 54)
Query Neighborhood Hits	190	Target Neighborhood Hits	357	Shared Neighborhood Hits	100
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
θ value	5.97985e-28 (rank : 24)	NC score	0.905425 (rank : 55)
Query Neighborhood Hits	190	Target Neighborhood Hits	358	Shared Neighborhood Hits	102
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX48_HUMAN
θ value	5.97985e-28 (rank : 25)	NC score	0.918634 (rank : 31)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
θ value	5.97985e-28 (rank : 26)	NC score	0.918482 (rank : 32)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX43_HUMAN
θ value	3.87602e-27 (rank : 27)	NC score	0.924561 (rank : 24)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX23_HUMAN
θ value	6.61148e-27 (rank : 28)	NC score	0.900346 (rank : 56)
Query Neighborhood Hits	190	Target Neighborhood Hits	486	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX56_HUMAN
θ value	6.61148e-27 (rank : 29)	NC score	0.922389 (rank : 27)
Query Neighborhood Hits	190	Target Neighborhood Hits	77	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX3Y_MOUSE
θ value	1.12775e-26 (rank : 30)	NC score	0.911440 (rank : 47)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX56_MOUSE
θ value	1.12775e-26 (rank : 31)	NC score	0.921299 (rank : 28)
Query Neighborhood Hits	190	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX31_HUMAN
θ value	1.92365e-26 (rank : 32)	NC score	0.930129 (rank : 16)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX3X_HUMAN
θ value	1.92365e-26 (rank : 33)	NC score	0.910277 (rank : 51)
Query Neighborhood Hits	190	Target Neighborhood Hits	122	Shared Neighborhood Hits	88
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
θ value	4.28545e-26 (rank : 34)	NC score	0.909567 (rank : 52)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

PL10_MOUSE
θ value	4.28545e-26 (rank : 35)	NC score	0.910320 (rank : 50)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3Y_HUMAN
θ value	9.54697e-26 (rank : 36)	NC score	0.907734 (rank : 53)
Query Neighborhood Hits	190	Target Neighborhood Hits	121	Shared Neighborhood Hits	87
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX28_HUMAN
θ value	1.24688e-25 (rank : 37)	NC score	0.926474 (rank : 19)
Query Neighborhood Hits	190	Target Neighborhood Hits	103	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX28_MOUSE
θ value	1.24688e-25 (rank : 38)	NC score	0.928753 (rank : 17)
Query Neighborhood Hits	190	Target Neighborhood Hits	112	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

IF4A1_HUMAN
θ value	4.73814e-25 (rank : 39)	NC score	0.912849 (rank : 42)
Query Neighborhood Hits	190	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
θ value	4.73814e-25 (rank : 40)	NC score	0.912849 (rank : 43)
Query Neighborhood Hits	190	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A2_HUMAN
θ value	4.73814e-25 (rank : 41)	NC score	0.912483 (rank : 45)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
θ value	4.73814e-25 (rank : 42)	NC score	0.912483 (rank : 46)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX39_HUMAN
θ value	1.05554e-24 (rank : 43)	NC score	0.915274 (rank : 36)
Query Neighborhood Hits	190	Target Neighborhood Hits	94	Shared Neighborhood Hits	85
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
θ value	1.80048e-24 (rank : 44)	NC score	0.914840 (rank : 37)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX50_MOUSE
θ value	4.01107e-24 (rank : 45)	NC score	0.911056 (rank : 48)
Query Neighborhood Hits	190	Target Neighborhood Hits	137	Shared Neighborhood Hits	92
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX4_HUMAN
θ value	5.23862e-24 (rank : 46)	NC score	0.916946 (rank : 34)
Query Neighborhood Hits	190	Target Neighborhood Hits	123	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX50_HUMAN
θ value	5.23862e-24 (rank : 47)	NC score	0.910536 (rank : 49)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX6_HUMAN
θ value	5.23862e-24 (rank : 48)	NC score	0.923597 (rank : 25)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
θ value	5.23862e-24 (rank : 49)	NC score	0.923585 (rank : 26)
Query Neighborhood Hits	190	Target Neighborhood Hits	98	Shared Neighborhood Hits	84
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX4_MOUSE
θ value	8.93572e-24 (rank : 50)	NC score	0.917514 (rank : 33)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

UAP56_HUMAN
θ value	8.93572e-24 (rank : 51)	NC score	0.913802 (rank : 39)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
θ value	8.93572e-24 (rank : 52)	NC score	0.913732 (rank : 40)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX53_HUMAN
θ value	1.5242e-23 (rank : 53)	NC score	0.916856 (rank : 35)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX51_MOUSE
θ value	4.43474e-23 (rank : 54)	NC score	0.914404 (rank : 38)
Query Neighborhood Hits	190	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX21_HUMAN
θ value	5.79196e-23 (rank : 55)	NC score	0.899497 (rank : 57)
Query Neighborhood Hits	190	Target Neighborhood Hits	308	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX1_MOUSE
θ value	3.75424e-22 (rank : 56)	NC score	0.870999 (rank : 67)
Query Neighborhood Hits	190	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX21_MOUSE
θ value	8.36355e-22 (rank : 57)	NC score	0.892264 (rank : 61)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX1_HUMAN
θ value	1.09232e-21 (rank : 58)	NC score	0.869761 (rank : 68)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	84
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

DDX51_HUMAN
θ value	1.86321e-21 (rank : 59)	NC score	0.897591 (rank : 59)
Query Neighborhood Hits	190	Target Neighborhood Hits	332	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX20_MOUSE
θ value	3.88503e-19 (rank : 60)	NC score	0.896185 (rank : 60)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX20_HUMAN
θ value	6.62687e-19 (rank : 61)	NC score	0.898933 (rank : 58)
Query Neighborhood Hits	190	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX52_HUMAN
θ value	2.13179e-17 (rank : 62)	NC score	0.913060 (rank : 41)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DDX52_MOUSE
θ value	2.13179e-17 (rank : 63)	NC score	0.912606 (rank : 44)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

DD19A_HUMAN
θ value	2.35696e-16 (rank : 64)	NC score	0.881676 (rank : 62)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
θ value	4.02038e-16 (rank : 65)	NC score	0.880638 (rank : 63)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_MOUSE
θ value	1.52774e-15 (rank : 66)	NC score	0.879955 (rank : 64)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	82
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX25_MOUSE
θ value	3.18553e-13 (rank : 67)	NC score	0.877940 (rank : 66)
Query Neighborhood Hits	190	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_HUMAN
θ value	9.26847e-13 (rank : 68)	NC score	0.878419 (rank : 65)
Query Neighborhood Hits	190	Target Neighborhood Hits	93	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

WRN_HUMAN
θ value	8.40245e-06 (rank : 69)	NC score	0.468722 (rank : 73)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	83
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ1_MOUSE
θ value	0.000121331 (rank : 70)	NC score	0.434389 (rank : 74)
Query Neighborhood Hits	190	Target Neighborhood Hits	95	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

DICER_HUMAN
θ value	0.00102713 (rank : 71)	NC score	0.402072 (rank : 80)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
θ value	0.00102713 (rank : 72)	NC score	0.401518 (rank : 81)
Query Neighborhood Hits	190	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

WRN_MOUSE
θ value	0.00102713 (rank : 73)	NC score	0.429309 (rank : 77)
Query Neighborhood Hits	190	Target Neighborhood Hits	295	Shared Neighborhood Hits	88
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

BLM_HUMAN
θ value	0.00509761 (rank : 74)	NC score	0.473534 (rank : 72)
Query Neighborhood Hits	190	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

BLM_MOUSE
θ value	0.00665767 (rank : 75)	NC score	0.484691 (rank : 71)
Query Neighborhood Hits	190	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

RECQ1_HUMAN
θ value	0.00869519 (rank : 76)	NC score	0.429340 (rank : 76)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ4_MOUSE
θ value	0.0113563 (rank : 77)	NC score	0.510439 (rank : 70)
Query Neighborhood Hits	190	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

RECQ4_HUMAN
θ value	0.0193708 (rank : 78)	NC score	0.526881 (rank : 69)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	87
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

TTC16_HUMAN
θ value	0.0252991 (rank : 79)	NC score	0.034128 (rank : 96)
Query Neighborhood Hits	190	Target Neighborhood Hits	417	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

FANCM_HUMAN
θ value	0.0563607 (rank : 80)	NC score	0.407673 (rank : 78)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

ARMX2_HUMAN
θ value	0.0736092 (rank : 81)	NC score	0.019376 (rank : 108)
Query Neighborhood Hits	190	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

FANCM_MOUSE
θ value	0.0736092 (rank : 82)	NC score	0.404540 (rank : 79)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

CC026_MOUSE
θ value	0.163984 (rank : 83)	NC score	0.147605 (rank : 89)
Query Neighborhood Hits	190	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

CD2L1_HUMAN
θ value	0.21417 (rank : 84)	NC score	0.000664 (rank : 177)
Query Neighborhood Hits	190	Target Neighborhood Hits	1467	Shared Neighborhood Hits	35
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	0.21417 (rank : 85)	NC score	0.000456 (rank : 178)
Query Neighborhood Hits	190	Target Neighborhood Hits	1463	Shared Neighborhood Hits	35
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

GP149_MOUSE
θ value	0.21417 (rank : 86)	NC score	0.031580 (rank : 97)
Query Neighborhood Hits	190	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UVY1, Q3TMB1, Q80T52, Q8BXA3, Q8BZC0	Gene names	Gpr149, Pgr10
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10).

IFIH1_MOUSE
θ value	0.21417 (rank : 87)	NC score	0.291840 (rank : 84)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

APTX_MOUSE
θ value	0.279714 (rank : 88)	NC score	0.023730 (rank : 102)
Query Neighborhood Hits	190	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

CD2L2_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.000034 (rank : 180)
Query Neighborhood Hits	190	Target Neighborhood Hits	1439	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

MP2K7_HUMAN
θ value	0.47712 (rank : 90)	NC score	-0.000278 (rank : 181)
Query Neighborhood Hits	190	Target Neighborhood Hits	833	Shared Neighborhood Hits	11
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

ANK3_HUMAN
θ value	0.62314 (rank : 91)	NC score	0.002995 (rank : 169)
Query Neighborhood Hits	190	Target Neighborhood Hits	853	Shared Neighborhood Hits	37
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

CCD41_HUMAN
θ value	0.62314 (rank : 92)	NC score	0.004482 (rank : 166)
Query Neighborhood Hits	190	Target Neighborhood Hits	1139	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

IFIH1_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.302618 (rank : 82)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

NCKX1_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.015616 (rank : 119)
Query Neighborhood Hits	190	Target Neighborhood Hits	223	Shared Neighborhood Hits	13
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

NFH_MOUSE
θ value	0.62314 (rank : 95)	NC score	0.012796 (rank : 127)
Query Neighborhood Hits	190	Target Neighborhood Hits	2247	Shared Neighborhood Hits	81
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TMCO3_HUMAN
θ value	0.62314 (rank : 96)	NC score	0.016490 (rank : 116)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UWJ1, Q5JSB1, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2	Gene names	TMCO3, C13orf11
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor (Putative LAG1-interacting protein).

ARNT2_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.012311 (rank : 131)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0.813845 (rank : 98)	NC score	0.012441 (rank : 128)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

GTSE1_MOUSE
θ value	0.813845 (rank : 99)	NC score	0.017971 (rank : 112)
Query Neighborhood Hits	190	Target Neighborhood Hits	245	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

PALM_MOUSE
θ value	0.813845 (rank : 100)	NC score	0.021184 (rank : 106)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

PCLO_MOUSE
θ value	0.813845 (rank : 101)	NC score	0.007782 (rank : 156)
Query Neighborhood Hits	190	Target Neighborhood Hits	2275	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TAI12_MOUSE
θ value	0.813845 (rank : 102)	NC score	0.017261 (rank : 114)
Query Neighborhood Hits	190	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGQ2, Q3UIH1	Gene names	Taip12
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

DIDO1_HUMAN
θ value	1.06291 (rank : 103)	NC score	0.011607 (rank : 133)
Query Neighborhood Hits	190	Target Neighborhood Hits	960	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GP149_HUMAN
θ value	1.06291 (rank : 104)	NC score	0.027558 (rank : 99)
Query Neighborhood Hits	190	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SP6	Gene names	GPR149, PGR10
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10).

NIPBL_HUMAN
θ value	1.06291 (rank : 105)	NC score	0.042207 (rank : 94)
Query Neighborhood Hits	190	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

PININ_MOUSE
θ value	1.06291 (rank : 106)	NC score	0.018706 (rank : 110)
Query Neighborhood Hits	190	Target Neighborhood Hits	777	Shared Neighborhood Hits	38
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

T22D3_HUMAN
θ value	1.06291 (rank : 107)	NC score	0.015060 (rank : 121)
Query Neighborhood Hits	190	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q99576, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5, Q9UG13	Gene names	TSC22D3, DSIPI, GILZ
Domain Architecture
Description	TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein) (Delta sleep-inducing peptide immunoreactor) (DSIP- immunoreactive peptide) (Protein DIP) (hDIP) (TSC-22-like protein) (TSC-22R).

CHD8_HUMAN
θ value	1.38821 (rank : 108)	NC score	0.013090 (rank : 126)
Query Neighborhood Hits	190	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

CN092_MOUSE
θ value	1.38821 (rank : 109)	NC score	0.010986 (rank : 137)
Query Neighborhood Hits	190	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

GON4L_MOUSE
θ value	1.38821 (rank : 110)	NC score	0.011255 (rank : 135)
Query Neighborhood Hits	190	Target Neighborhood Hits	455	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

STK33_HUMAN
θ value	1.38821 (rank : 111)	NC score	-0.004346 (rank : 191)
Query Neighborhood Hits	190	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

TRDN_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.023519 (rank : 103)
Query Neighborhood Hits	190	Target Neighborhood Hits	542	Shared Neighborhood Hits	35
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

ABTAP_HUMAN
θ value	1.81305 (rank : 113)	NC score	0.011854 (rank : 132)
Query Neighborhood Hits	190	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

FA47B_HUMAN
θ value	1.81305 (rank : 114)	NC score	0.010072 (rank : 141)
Query Neighborhood Hits	190	Target Neighborhood Hits	431	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MINT_MOUSE
θ value	1.81305 (rank : 115)	NC score	0.019584 (rank : 107)
Query Neighborhood Hits	190	Target Neighborhood Hits	1514	Shared Neighborhood Hits	55
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PHF20_MOUSE
θ value	1.81305 (rank : 116)	NC score	0.044000 (rank : 93)
Query Neighborhood Hits	190	Target Neighborhood Hits	513	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

TACC2_MOUSE
θ value	1.81305 (rank : 117)	NC score	0.005752 (rank : 162)
Query Neighborhood Hits	190	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TAF4_HUMAN
θ value	1.81305 (rank : 118)	NC score	0.013133 (rank : 125)
Query Neighborhood Hits	190	Target Neighborhood Hits	687	Shared Neighborhood Hits	19
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

UBP10_MOUSE
θ value	1.81305 (rank : 119)	NC score	0.009318 (rank : 144)
Query Neighborhood Hits	190	Target Neighborhood Hits	150	Shared Neighborhood Hits	10
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

AKAP1_HUMAN
θ value	2.36792 (rank : 120)	NC score	0.011229 (rank : 136)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

ARX_HUMAN
θ value	2.36792 (rank : 121)	NC score	-0.000486 (rank : 182)
Query Neighborhood Hits	190	Target Neighborhood Hits	401	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

EP400_MOUSE
θ value	2.36792 (rank : 122)	NC score	0.008102 (rank : 152)
Query Neighborhood Hits	190	Target Neighborhood Hits	592	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

ESCO1_HUMAN
θ value	2.36792 (rank : 123)	NC score	0.023330 (rank : 104)
Query Neighborhood Hits	190	Target Neighborhood Hits	361	Shared Neighborhood Hits	21
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

NFH_HUMAN
θ value	2.36792 (rank : 124)	NC score	0.008061 (rank : 153)
Query Neighborhood Hits	190	Target Neighborhood Hits	1242	Shared Neighborhood Hits	51
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RBBP8_HUMAN
θ value	2.36792 (rank : 125)	NC score	0.016052 (rank : 118)
Query Neighborhood Hits	190	Target Neighborhood Hits	476	Shared Neighborhood Hits	19
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

ST5_MOUSE
θ value	2.36792 (rank : 126)	NC score	0.008560 (rank : 148)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

TRPS1_MOUSE
θ value	2.36792 (rank : 127)	NC score	0.006326 (rank : 160)
Query Neighborhood Hits	190	Target Neighborhood Hits	609	Shared Neighborhood Hits	16
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

AFF2_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.010028 (rank : 143)
Query Neighborhood Hits	190	Target Neighborhood Hits	218	Shared Neighborhood Hits	15
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

AP3B1_HUMAN
θ value	3.0926 (rank : 129)	NC score	0.007594 (rank : 158)
Query Neighborhood Hits	190	Target Neighborhood Hits	283	Shared Neighborhood Hits	17
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

PELP1_HUMAN
θ value	3.0926 (rank : 130)	NC score	0.010428 (rank : 139)
Query Neighborhood Hits	190	Target Neighborhood Hits	596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

RSF1_HUMAN
θ value	3.0926 (rank : 131)	NC score	0.014233 (rank : 123)
Query Neighborhood Hits	190	Target Neighborhood Hits	539	Shared Neighborhood Hits	32
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SIAL_MOUSE
θ value	3.0926 (rank : 132)	NC score	0.017722 (rank : 113)
Query Neighborhood Hits	190	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q61711, Q61363	Gene names	Ibsp
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

SRBP1_MOUSE
θ value	3.0926 (rank : 133)	NC score	0.007614 (rank : 157)
Query Neighborhood Hits	190	Target Neighborhood Hits	384	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TAI12_HUMAN
θ value	3.0926 (rank : 134)	NC score	0.014513 (rank : 122)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

TISD_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.008772 (rank : 147)
Query Neighborhood Hits	190	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

U520_HUMAN
θ value	3.0926 (rank : 136)	NC score	0.131961 (rank : 90)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

BRD2_HUMAN
θ value	4.03905 (rank : 137)	NC score	0.005965 (rank : 161)
Query Neighborhood Hits	190	Target Neighborhood Hits	242	Shared Neighborhood Hits	15
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

JHD3C_MOUSE
θ value	4.03905 (rank : 138)	NC score	0.003704 (rank : 167)
Query Neighborhood Hits	190	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCD7, Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1	Gene names	Jmjd2c, Jhdm3c, Kiaa0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C).

MCF2L_MOUSE
θ value	4.03905 (rank : 139)	NC score	0.002918 (rank : 170)
Query Neighborhood Hits	190	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MRCKB_MOUSE
θ value	4.03905 (rank : 140)	NC score	-0.001561 (rank : 185)
Query Neighborhood Hits	190	Target Neighborhood Hits	2180	Shared Neighborhood Hits	43
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PLCB2_HUMAN
θ value	4.03905 (rank : 141)	NC score	0.008514 (rank : 149)
Query Neighborhood Hits	190	Target Neighborhood Hits	608	Shared Neighborhood Hits	20
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

TCF8_MOUSE
θ value	4.03905 (rank : 142)	NC score	-0.005772 (rank : 194)
Query Neighborhood Hits	190	Target Neighborhood Hits	1067	Shared Neighborhood Hits	21
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

TCOF_MOUSE
θ value	4.03905 (rank : 143)	NC score	0.018132 (rank : 111)
Query Neighborhood Hits	190	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

ZBT17_MOUSE
θ value	4.03905 (rank : 144)	NC score	-0.007317 (rank : 196)
Query Neighborhood Hits	190	Target Neighborhood Hits	940	Shared Neighborhood Hits	15
SwissProt Accessions	Q60821, Q60699	Gene names	Zbtb17, Zfp100, Znf151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Zinc finger protein 100) (Zfp-100) (Polyomavirus late initiator promoter-binding protein) (LP-1) (Zinc finger protein Z13).

ARX_MOUSE
θ value	5.27518 (rank : 145)	NC score	-0.001046 (rank : 184)
Query Neighborhood Hits	190	Target Neighborhood Hits	398	Shared Neighborhood Hits	5
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

ATRX_HUMAN
θ value	5.27518 (rank : 146)	NC score	0.021859 (rank : 105)
Query Neighborhood Hits	190	Target Neighborhood Hits	842	Shared Neighborhood Hits	51
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

CCDC4_HUMAN
θ value	5.27518 (rank : 147)	NC score	0.012400 (rank : 129)
Query Neighborhood Hits	190	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

GOGA4_HUMAN
θ value	5.27518 (rank : 148)	NC score	0.008145 (rank : 151)
Query Neighborhood Hits	190	Target Neighborhood Hits	2034	Shared Neighborhood Hits	56
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GPTC8_HUMAN
θ value	5.27518 (rank : 149)	NC score	0.016768 (rank : 115)
Query Neighborhood Hits	190	Target Neighborhood Hits	366	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

GSLG1_HUMAN
θ value	5.27518 (rank : 150)	NC score	0.011515 (rank : 134)
Query Neighborhood Hits	190	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q92896, Q13221	Gene names	GLG1, CFR1, ESL1, MG160
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Cysteine-rich fibroblast growth factor receptor) (CFR-1).

MK15_MOUSE
θ value	5.27518 (rank : 151)	NC score	-0.003339 (rank : 190)
Query Neighborhood Hits	190	Target Neighborhood Hits	843	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MO4L2_MOUSE
θ value	5.27518 (rank : 152)	NC score	0.013761 (rank : 124)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

NKTR_HUMAN
θ value	5.27518 (rank : 153)	NC score	0.024441 (rank : 101)
Query Neighborhood Hits	190	Target Neighborhood Hits	658	Shared Neighborhood Hits	51
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

SET1A_HUMAN
θ value	5.27518 (rank : 154)	NC score	0.008194 (rank : 150)
Query Neighborhood Hits	190	Target Neighborhood Hits	690	Shared Neighborhood Hits	31
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ST5_HUMAN
θ value	5.27518 (rank : 155)	NC score	0.008033 (rank : 154)
Query Neighborhood Hits	190	Target Neighborhood Hits	151	Shared Neighborhood Hits	7
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

ZBTB3_HUMAN
θ value	5.27518 (rank : 156)	NC score	-0.004737 (rank : 193)
Query Neighborhood Hits	190	Target Neighborhood Hits	910	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H5J0	Gene names	ZBTB3
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 3.

ZN142_HUMAN
θ value	5.27518 (rank : 157)	NC score	-0.006429 (rank : 195)
Query Neighborhood Hits	190	Target Neighborhood Hits	1007	Shared Neighborhood Hits	17
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ASTL_HUMAN
θ value	6.88961 (rank : 158)	NC score	0.005390 (rank : 163)
Query Neighborhood Hits	190	Target Neighborhood Hits	252	Shared Neighborhood Hits	12
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

CG1_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.016097 (rank : 117)
Query Neighborhood Hits	190	Target Neighborhood Hits	222	Shared Neighborhood Hits	15
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CJ012_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.018964 (rank : 109)
Query Neighborhood Hits	190	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

DZIP1_MOUSE
θ value	6.88961 (rank : 161)	NC score	0.002697 (rank : 173)
Query Neighborhood Hits	190	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

GSLG1_MOUSE
θ value	6.88961 (rank : 162)	NC score	0.010860 (rank : 138)
Query Neighborhood Hits	190	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q61543, Q9QZ40	Gene names	Glg1, Esl1, Mg160, Selel
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Selel).

LEO1_MOUSE
θ value	6.88961 (rank : 163)	NC score	0.036268 (rank : 95)
Query Neighborhood Hits	190	Target Neighborhood Hits	946	Shared Neighborhood Hits	59
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LGP2_HUMAN
θ value	6.88961 (rank : 164)	NC score	0.288408 (rank : 85)
Query Neighborhood Hits	190	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

MADCA_HUMAN
θ value	6.88961 (rank : 165)	NC score	0.008900 (rank : 146)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	13
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MINT_HUMAN
θ value	6.88961 (rank : 166)	NC score	0.015133 (rank : 120)
Query Neighborhood Hits	190	Target Neighborhood Hits	1291	Shared Neighborhood Hits	54
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MYPT1_MOUSE
θ value	6.88961 (rank : 167)	NC score	0.000895 (rank : 175)
Query Neighborhood Hits	190	Target Neighborhood Hits	539	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

NCA11_MOUSE
θ value	6.88961 (rank : 168)	NC score	-0.001860 (rank : 186)
Query Neighborhood Hits	190	Target Neighborhood Hits	661	Shared Neighborhood Hits	17
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

RBBP6_MOUSE
θ value	6.88961 (rank : 169)	NC score	0.026728 (rank : 100)
Query Neighborhood Hits	190	Target Neighborhood Hits	1014	Shared Neighborhood Hits	53
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SEL1L_MOUSE
θ value	6.88961 (rank : 170)	NC score	0.004822 (rank : 164)
Query Neighborhood Hits	190	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEPT9_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.003294 (rank : 168)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

ANR26_MOUSE
θ value	8.99809 (rank : 172)	NC score	-0.002275 (rank : 187)
Query Neighborhood Hits	190	Target Neighborhood Hits	1554	Shared Neighborhood Hits	40
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ATRX_MOUSE
θ value	8.99809 (rank : 173)	NC score	0.012339 (rank : 130)
Query Neighborhood Hits	190	Target Neighborhood Hits	682	Shared Neighborhood Hits	39
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

BAZ1B_HUMAN
θ value	8.99809 (rank : 174)	NC score	0.010066 (rank : 142)
Query Neighborhood Hits	190	Target Neighborhood Hits	701	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CCD96_MOUSE
θ value	8.99809 (rank : 175)	NC score	0.002773 (rank : 171)
Query Neighborhood Hits	190	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CPSF7_HUMAN
θ value	8.99809 (rank : 176)	NC score	0.004604 (rank : 165)
Query Neighborhood Hits	190	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

CSPG2_HUMAN
θ value	8.99809 (rank : 177)	NC score	-0.003157 (rank : 189)
Query Neighborhood Hits	190	Target Neighborhood Hits	681	Shared Neighborhood Hits	9
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

CTR9_MOUSE
θ value	8.99809 (rank : 178)	NC score	0.007902 (rank : 155)
Query Neighborhood Hits	190	Target Neighborhood Hits	427	Shared Neighborhood Hits	25
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

EHMT1_HUMAN
θ value	8.99809 (rank : 179)	NC score	-0.000527 (rank : 183)
Query Neighborhood Hits	190	Target Neighborhood Hits	417	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

IWS1_HUMAN
θ value	8.99809 (rank : 180)	NC score	0.029609 (rank : 98)
Query Neighborhood Hits	190	Target Neighborhood Hits	1241	Shared Neighborhood Hits	64
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYH11_MOUSE
θ value	8.99809 (rank : 181)	NC score	0.000665 (rank : 176)
Query Neighborhood Hits	190	Target Neighborhood Hits	1777	Shared Neighborhood Hits	46
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYLK2_HUMAN
θ value	8.99809 (rank : 182)	NC score	-0.004578 (rank : 192)
Query Neighborhood Hits	190	Target Neighborhood Hits	920	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

NEBL_HUMAN
θ value	8.99809 (rank : 183)	NC score	0.002090 (rank : 174)
Query Neighborhood Hits	190	Target Neighborhood Hits	457	Shared Neighborhood Hits	16
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEST_HUMAN
θ value	8.99809 (rank : 184)	NC score	0.006380 (rank : 159)
Query Neighborhood Hits	190	Target Neighborhood Hits	1305	Shared Neighborhood Hits	45
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NU214_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.010327 (rank : 140)
Query Neighborhood Hits	190	Target Neighborhood Hits	657	Shared Neighborhood Hits	21
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

OS9_HUMAN
θ value	8.99809 (rank : 186)	NC score	0.009152 (rank : 145)
Query Neighborhood Hits	190	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

PYGM_MOUSE
θ value	8.99809 (rank : 187)	NC score	0.002716 (rank : 172)
Query Neighborhood Hits	190	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB3	Gene names	Pygm
Domain Architecture
Description	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase).

RECQ5_HUMAN
θ value	8.99809 (rank : 188)	NC score	0.430230 (rank : 75)
Query Neighborhood Hits	190	Target Neighborhood Hits	390	Shared Neighborhood Hits	90
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

TXLNG_MOUSE
θ value	8.99809 (rank : 189)	NC score	0.000142 (rank : 179)
Query Neighborhood Hits	190	Target Neighborhood Hits	552	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

WEE1B_HUMAN
θ value	8.99809 (rank : 190)	NC score	-0.002438 (rank : 188)
Query Neighborhood Hits	190	Target Neighborhood Hits	836	Shared Neighborhood Hits	21
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CC026_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.162077 (rank : 87)
Query Neighborhood Hits	190	Target Neighborhood Hits	39	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

DDX58_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.153440 (rank : 88)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	55
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

DDX58_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.184295 (rank : 86)
Query Neighborhood Hits	190	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

HELC1_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.089487 (rank : 91)
Query Neighborhood Hits	190	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

LGP2_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.296520 (rank : 83)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

SMAL1_HUMAN
θ value	θ > 10 (rank : 196)	NC score	0.073053 (rank : 92)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

Hits sorted by NC score

DDX24_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	190	Target Neighborhood Hits	190	Shared Neighborhood Hits	190
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX24_MOUSE
NC score	0.992652 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	190	Target Neighborhood Hits	147	Shared Neighborhood Hits	97
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

DDX47_MOUSE
NC score	0.949864 (rank : 3)	θ value	8.30557e-46 (rank : 4)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	Q9CWX9	Gene names	Ddx47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX47_HUMAN
NC score	0.949644 (rank : 4)	θ value	3.72821e-46 (rank : 3)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	Q9H0S4, Q96GM0, Q96NV8	Gene names	DDX47
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX47 (EC 3.6.1.-) (DEAD box protein 47).

DDX49_MOUSE
NC score	0.945605 (rank : 5)	θ value	1.6774e-38 (rank : 6)
Query Neighborhood Hits	190	Target Neighborhood Hits	119	Shared Neighborhood Hits	86
SwissProt Accessions	Q4FZF3	Gene names	Ddx49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX49_HUMAN
NC score	0.943132 (rank : 6)	θ value	1.79215e-40 (rank : 5)
Query Neighborhood Hits	190	Target Neighborhood Hits	223	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DDX27_MOUSE
NC score	0.934666 (rank : 7)	θ value	9.52487e-34 (rank : 9)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	89
SwissProt Accessions	Q921N6, Q8R0W3, Q8R1E2	Gene names	Ddx27
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX18_HUMAN
NC score	0.933609 (rank : 8)	θ value	1.46948e-34 (rank : 7)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NVP1, Q6IAU4, Q92732, Q9BQB7	Gene names	DDX18
Domain Architecture
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18) (Myc-regulated DEAD box protein) (MrDb).

DDX18_MOUSE
NC score	0.933474 (rank : 9)	θ value	2.50655e-34 (rank : 8)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K363, Q3MIB0, Q8BVZ2, Q9D2E0	Gene names	Ddx18
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX18 (EC 3.6.1.-) (DEAD box protein 18).

DDX55_MOUSE
NC score	0.933048 (rank : 10)	θ value	1.4233e-29 (rank : 20)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZPL9, Q149H5, Q3U460, Q8BZR1	Gene names	Ddx55, Kiaa1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX41_HUMAN
NC score	0.932960 (rank : 11)	θ value	2.77131e-33 (rank : 10)
Query Neighborhood Hits	190	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV9, Q96BK6, Q96K05, Q9NT96, Q9NW04	Gene names	DDX41, ABS
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41) (DEAD box protein abstrakt homolog).

DDX27_HUMAN
NC score	0.932956 (rank : 12)	θ value	6.17384e-33 (rank : 14)
Query Neighborhood Hits	190	Target Neighborhood Hits	197	Shared Neighborhood Hits	89
SwissProt Accessions	Q96GQ7, Q5VXM7, Q8WYG4, Q969N7, Q96F57, Q96L97, Q9BWY9, Q9BXF0, Q9H990, Q9NWU3, Q9P0C2, Q9UGD6	Gene names	DDX27, RHLP
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) (DEAD box protein 27).

DDX41_MOUSE
NC score	0.932641 (rank : 13)	θ value	2.77131e-33 (rank : 11)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VN6	Gene names	Ddx41
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.1.-) (DEAD box protein 41).

DDX54_MOUSE
NC score	0.931930 (rank : 14)	θ value	1.52067e-31 (rank : 15)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K4L0	Gene names	Ddx54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54).

DDX55_HUMAN
NC score	0.931458 (rank : 15)	θ value	1.08979e-29 (rank : 19)
Query Neighborhood Hits	190	Target Neighborhood Hits	122	Shared Neighborhood Hits	83
SwissProt Accessions	Q8NHQ9, Q658L6, Q9HCH7	Gene names	DDX55, KIAA1595
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX55 (EC 3.6.1.-) (DEAD box protein 55).

DDX31_HUMAN
NC score	0.930129 (rank : 16)	θ value	1.92365e-26 (rank : 32)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	86
SwissProt Accessions	Q9H8H2, Q5K6N2, Q5K6N3, Q5K6N4, Q5VZJ4, Q5VZJ9, Q96E91, Q96NY2, Q96SX5, Q9H5K6	Gene names	DDX31
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX31 (EC 3.6.1.-) (DEAD box protein 31) (Helicain).

DDX28_MOUSE
NC score	0.928753 (rank : 17)	θ value	1.24688e-25 (rank : 38)
Query Neighborhood Hits	190	Target Neighborhood Hits	112	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX54_HUMAN
NC score	0.927540 (rank : 18)	θ value	8.3442e-30 (rank : 18)
Query Neighborhood Hits	190	Target Neighborhood Hits	170	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TDD1, Q86YT8, Q9BRZ1	Gene names	DDX54
Domain Architecture
Description	ATP-dependent RNA helicase DDX54 (EC 3.6.1.-) (DEAD box protein 54) (ATP-dependent RNA helicase DP97).

DDX28_HUMAN
NC score	0.926474 (rank : 19)	θ value	1.24688e-25 (rank : 37)
Query Neighborhood Hits	190	Target Neighborhood Hits	103	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NUL7	Gene names	DDX28, MDDX28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

DDX17_MOUSE
NC score	0.926298 (rank : 20)	θ value	6.17384e-33 (rank : 13)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	84
SwissProt Accessions	Q501J6, Q6P5G1, Q8BIN2	Gene names	Ddx17
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17).

DDX17_HUMAN
NC score	0.926165 (rank : 21)	θ value	6.17384e-33 (rank : 12)
Query Neighborhood Hits	190	Target Neighborhood Hits	104	Shared Neighborhood Hits	84
SwissProt Accessions	Q92841, Q69YT1, Q6ICD6	Gene names	DDX17
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX17 (EC 3.6.1.-) (DEAD box protein 17) (RNA-dependent helicase p72) (DEAD box protein p72).

DDX10_HUMAN
NC score	0.925860 (rank : 22)	θ value	5.77852e-31 (rank : 16)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	89
SwissProt Accessions	Q13206, Q5BJD8	Gene names	DDX10
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX10_MOUSE
NC score	0.925287 (rank : 23)	θ value	4.89182e-30 (rank : 17)
Query Neighborhood Hits	190	Target Neighborhood Hits	233	Shared Neighborhood Hits	88
SwissProt Accessions	Q80Y44	Gene names	Ddx10
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX10 (EC 3.6.1.-) (DEAD box protein 10).

DDX43_HUMAN
NC score	0.924561 (rank : 24)	θ value	3.87602e-27 (rank : 27)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NXZ2, Q6NXR1	Gene names	DDX43, HAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX43 (EC 3.6.1.-) (DEAD box protein 43) (DEAD box protein HAGE) (Helical antigen).

DDX6_HUMAN
NC score	0.923597 (rank : 25)	θ value	5.23862e-24 (rank : 48)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	84
SwissProt Accessions	P26196	Gene names	DDX6, HLR2, RCK
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK).

DDX6_MOUSE
NC score	0.923585 (rank : 26)	θ value	5.23862e-24 (rank : 49)
Query Neighborhood Hits	190	Target Neighborhood Hits	98	Shared Neighborhood Hits	84
SwissProt Accessions	P54823	Gene names	Ddx6, Hlr2, Rck
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.1.-) (DEAD box protein 6) (ATP-dependent RNA helicase p54) (Oncogene RCK homolog).

DDX56_HUMAN
NC score	0.922389 (rank : 27)	θ value	6.61148e-27 (rank : 29)
Query Neighborhood Hits	190	Target Neighborhood Hits	77	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NY93, Q9H9I8	Gene names	DDX56, DDX21, NOH61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD-box protein 21).

DDX56_MOUSE
NC score	0.921299 (rank : 28)	θ value	1.12775e-26 (rank : 31)
Query Neighborhood Hits	190	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D0R4	Gene names	Ddx56, D11Ertd619e, Noh61
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX56 (EC 3.6.1.-) (DEAD box protein 56) (ATP-dependent 61 kDa nucleolar RNA helicase).

DDX5_HUMAN
NC score	0.919632 (rank : 29)	θ value	5.40856e-29 (rank : 21)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P17844, O75681	Gene names	DDX5, HELR, HLR1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68).

DDX5_MOUSE
NC score	0.919611 (rank : 30)	θ value	5.40856e-29 (rank : 22)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	84
SwissProt Accessions	Q61656	Gene names	Ddx5, Tnz2
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX5 (EC 3.6.1.-) (DEAD box protein 5) (RNA helicase p68) (DEAD box RNA helicase DEAD1) (mDEAD1).

DDX48_HUMAN
NC score	0.918634 (rank : 31)	θ value	5.97985e-28 (rank : 25)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	P38919, Q15033, Q96A18	Gene names	DDX48, EIF4A3, KIAA0111
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3).

DDX48_MOUSE
NC score	0.918482 (rank : 32)	θ value	5.97985e-28 (rank : 26)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	85
SwissProt Accessions	Q91VC3	Gene names	Ddx48
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48).

DDX4_MOUSE
NC score	0.917514 (rank : 33)	θ value	8.93572e-24 (rank : 50)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	Q61496, Q9D5X7	Gene names	Ddx4, Vasa
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog) (Mvh).

DDX4_HUMAN
NC score	0.916946 (rank : 34)	θ value	5.23862e-24 (rank : 46)
Query Neighborhood Hits	190	Target Neighborhood Hits	123	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DDX53_HUMAN
NC score	0.916856 (rank : 35)	θ value	1.5242e-23 (rank : 53)
Query Neighborhood Hits	190	Target Neighborhood Hits	124	Shared Neighborhood Hits	81
SwissProt Accessions	Q86TM3, Q6NVV4	Gene names	DDX53, CAGE
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX53 (EC 3.6.1.-) (DEAD box protein 53) (DEAD box protein CAGE) (Cancer-associated gene protein).

DDX39_HUMAN
NC score	0.915274 (rank : 36)	θ value	1.05554e-24 (rank : 43)
Query Neighborhood Hits	190	Target Neighborhood Hits	94	Shared Neighborhood Hits	85
SwissProt Accessions	O00148, Q9BVP6, Q9H5W0	Gene names	DDX39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39) (Nuclear RNA helicase URH49).

DDX39_MOUSE
NC score	0.914840 (rank : 37)	θ value	1.80048e-24 (rank : 44)
Query Neighborhood Hits	190	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q8VDW0, Q3UJV4, Q8C2C2	Gene names	Ddx39
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX39 (EC 3.6.1.-) (DEAD box protein 39).

DDX51_MOUSE
NC score	0.914404 (rank : 38)	θ value	4.43474e-23 (rank : 54)
Query Neighborhood Hits	190	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	Q6P9R1, Q3U7M2	Gene names	Ddx51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

UAP56_HUMAN
NC score	0.913802 (rank : 39)	θ value	8.93572e-24 (rank : 51)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q13838, O43496, Q5RJ64, Q5RJ66, Q5ST94, Q5STB4, Q5STB5, Q5STB7, Q5STU4, Q5STU5, Q5STU6, Q5STU8, Q71V76	Gene names	BAT1, UAP56
Domain Architecture
Description	Spliceosome RNA helicase BAT1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (HLA-B-associated transcript-1).

UAP56_MOUSE
NC score	0.913732 (rank : 40)	θ value	8.93572e-24 (rank : 52)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Z1N5, Q8HW97	Gene names	Bat1, Bat1a, Uap56
Domain Architecture	No domain graphic available
Description	Spliceosome RNA helicase Bat1 (EC 3.6.1.-) (DEAD box protein UAP56) (56 kDa U2AF65-associated protein) (HLA-B-associated transcript 1).

DDX52_HUMAN
NC score	0.913060 (rank : 41)	θ value	2.13179e-17 (rank : 62)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y2R4, Q86YG1, Q8N213, Q9NVE0, Q9Y482	Gene names	DDX52, ROK1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

IF4A1_HUMAN
NC score	0.912849 (rank : 42)	θ value	4.73814e-25 (rank : 39)
Query Neighborhood Hits	190	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60842, P04765, Q5U018, Q61516	Gene names	EIF4A1, DDX2A, EIF4A
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

IF4A1_MOUSE
NC score	0.912849 (rank : 43)	θ value	4.73814e-25 (rank : 40)
Query Neighborhood Hits	190	Target Neighborhood Hits	106	Shared Neighborhood Hits	85
SwissProt Accessions	P60843, P04765, Q61516	Gene names	Eif4a1, Ddx2a, Eif4a
Domain Architecture
Description	Eukaryotic initiation factor 4A-I (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-1) (eIF4A-I) (eIF-4A-I).

DDX52_MOUSE
NC score	0.912606 (rank : 44)	θ value	2.13179e-17 (rank : 63)
Query Neighborhood Hits	190	Target Neighborhood Hits	101	Shared Neighborhood Hits	85
SwissProt Accessions	Q8K301, Q8BV29	Gene names	Ddx52, Rok1
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-) (DEAD box protein 52) (ATP-dependent RNA helicase ROK1-like).

IF4A2_HUMAN
NC score	0.912483 (rank : 45)	θ value	4.73814e-25 (rank : 41)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	Q14240, Q96B90, Q96EA8	Gene names	EIF4A2, DDX2B
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

IF4A2_MOUSE
NC score	0.912483 (rank : 46)	θ value	4.73814e-25 (rank : 42)
Query Neighborhood Hits	190	Target Neighborhood Hits	102	Shared Neighborhood Hits	84
SwissProt Accessions	P10630, Q61513, Q61514	Gene names	Eif4a2, Ddx2b
Domain Architecture
Description	Eukaryotic initiation factor 4A-II (EC 3.6.1.-) (ATP-dependent RNA helicase eIF4A-2) (eIF4A-II) (eIF-4A-II).

DDX3Y_MOUSE
NC score	0.911440 (rank : 47)	θ value	1.12775e-26 (rank : 30)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	87
SwissProt Accessions	Q62095, Q9QWS9	Gene names	Ddx3y, D1Pas1-rs1, Dead2
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal) (DEAD-box RNA helicase DEAD2) (mDEAD2) (D1Pas1-related sequence 1).

DDX50_MOUSE
NC score	0.911056 (rank : 48)	θ value	4.01107e-24 (rank : 45)
Query Neighborhood Hits	190	Target Neighborhood Hits	137	Shared Neighborhood Hits	92
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DDX50_HUMAN
NC score	0.910536 (rank : 49)	θ value	5.23862e-24 (rank : 47)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	86
SwissProt Accessions	Q9BQ39, Q8WV76, Q9BWI8	Gene names	DDX50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

PL10_MOUSE
NC score	0.910320 (rank : 50)	θ value	4.28545e-26 (rank : 35)
Query Neighborhood Hits	190	Target Neighborhood Hits	120	Shared Neighborhood Hits	87
SwissProt Accessions	P16381	Gene names	D1Pas1, Pl10
Domain Architecture
Description	Putative ATP-dependent RNA helicase Pl10 (EC 3.6.1.-).

DDX3X_HUMAN
NC score	0.910277 (rank : 51)	θ value	1.92365e-26 (rank : 33)
Query Neighborhood Hits	190	Target Neighborhood Hits	122	Shared Neighborhood Hits	88
SwissProt Accessions	O00571, O15536	Gene names	DDX3X, DBX, DDX3
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (Helicase-like protein 2) (HLP2) (DEAD box, X isoform).

DDX3X_MOUSE
NC score	0.909567 (rank : 52)	θ value	4.28545e-26 (rank : 34)
Query Neighborhood Hits	190	Target Neighborhood Hits	117	Shared Neighborhood Hits	87
SwissProt Accessions	Q62167, O09060, O09143	Gene names	Ddx3x, D1Pas1-rs2, Ddx3, Dead3, Erh
Domain Architecture
Description	ATP-dependent RNA helicase DDX3X (EC 3.6.1.-) (DEAD box protein 3, X- chromosomal) (DEAD box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1Pas1-related sequence 2).

DDX3Y_HUMAN
NC score	0.907734 (rank : 53)	θ value	9.54697e-26 (rank : 36)
Query Neighborhood Hits	190	Target Neighborhood Hits	121	Shared Neighborhood Hits	87
SwissProt Accessions	O15523, Q8IYV7	Gene names	DDX3Y, DBY
Domain Architecture
Description	ATP-dependent RNA helicase DDX3Y (EC 3.6.1.-) (DEAD box protein 3, Y- chromosomal).

DDX46_HUMAN
NC score	0.907071 (rank : 54)	θ value	5.97985e-28 (rank : 23)
Query Neighborhood Hits	190	Target Neighborhood Hits	357	Shared Neighborhood Hits	100
SwissProt Accessions	Q7L014, O94894, Q96EI0, Q9Y658	Gene names	DDX46, KIAA0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46) (PRP5 homolog).

DDX46_MOUSE
NC score	0.905425 (rank : 55)	θ value	5.97985e-28 (rank : 24)
Query Neighborhood Hits	190	Target Neighborhood Hits	358	Shared Neighborhood Hits	102
SwissProt Accessions	Q569Z5, Q6ZQ42, Q8R0R6	Gene names	Ddx46, Kiaa0801
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX46 (EC 3.6.1.-) (DEAD box protein 46).

DDX23_HUMAN
NC score	0.900346 (rank : 56)	θ value	6.61148e-27 (rank : 28)
Query Neighborhood Hits	190	Target Neighborhood Hits	486	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

DDX21_HUMAN
NC score	0.899497 (rank : 57)	θ value	5.79196e-23 (rank : 55)
Query Neighborhood Hits	190	Target Neighborhood Hits	308	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NR30, Q13436, Q5VX41, Q68D35	Gene names	DDX21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DDX20_HUMAN
NC score	0.898933 (rank : 58)	θ value	6.62687e-19 (rank : 61)
Query Neighborhood Hits	190	Target Neighborhood Hits	121	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UHI6, Q96F72, Q9NVM3, Q9UF59, Q9UIY0, Q9Y659	Gene names	DDX20, DP103, GEMIN3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3).

DDX51_HUMAN
NC score	0.897591 (rank : 59)	θ value	1.86321e-21 (rank : 59)
Query Neighborhood Hits	190	Target Neighborhood Hits	332	Shared Neighborhood Hits	98
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DDX20_MOUSE
NC score	0.896185 (rank : 60)	θ value	3.88503e-19 (rank : 60)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	92
SwissProt Accessions	Q9JJY4, Q9JIK4	Gene names	Ddx20, Dp103, Gemin3
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.-) (DEAD box protein 20) (DEAD box protein DP 103) (Component of gems 3) (Gemin-3) (Regulator of steroidogenic factor 1) (ROSF-1).

DDX21_MOUSE
NC score	0.892264 (rank : 61)	θ value	8.36355e-22 (rank : 57)
Query Neighborhood Hits	190	Target Neighborhood Hits	350	Shared Neighborhood Hits	105
SwissProt Accessions	Q9JIK5, Q9WV45	Gene names	Ddx21
Domain Architecture
Description	Nucleolar RNA helicase 2 (EC 3.6.1.-) (Nucleolar RNA helicase II) (Nucleolar RNA helicase Gu) (RH II/Gu) (Gu-alpha) (DEAD box protein 21).

DD19A_HUMAN
NC score	0.881676 (rank : 62)	θ value	2.35696e-16 (rank : 64)
Query Neighborhood Hits	190	Target Neighborhood Hits	107	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NUU7, Q53FM0	Gene names	DDX19A, DDX19L
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DDX19-like protein).

DD19B_HUMAN
NC score	0.880638 (rank : 63)	θ value	4.02038e-16 (rank : 65)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UMR2, Q6FIB7, Q6IAE0	Gene names	DDX19B, DBP5, DDX19
Domain Architecture
Description	ATP-dependent RNA helicase DDX19B (EC 3.6.1.-) (DEAD box protein 19B) (DEAD box RNA helicase DEAD5).

DD19A_MOUSE
NC score	0.879955 (rank : 64)	θ value	1.52774e-15 (rank : 66)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	82
SwissProt Accessions	Q61655, Q921R0	Gene names	Ddx19a, Ddx19, Eif4a-rs1
Domain Architecture
Description	ATP-dependent RNA helicase DDX19A (EC 3.6.1.-) (DEAD box protein 19A) (DEAD box RNA helicase DEAD5) (mDEAD5) (Eukaryotic translation initiation factor 4A-related sequence 1).

DDX25_HUMAN
NC score	0.878419 (rank : 65)	θ value	9.26847e-13 (rank : 68)
Query Neighborhood Hits	190	Target Neighborhood Hits	93	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UHL0, Q86W81, Q8IYP1	Gene names	DDX25, GRTH
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX25_MOUSE
NC score	0.877940 (rank : 66)	θ value	3.18553e-13 (rank : 67)
Query Neighborhood Hits	190	Target Neighborhood Hits	98	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QY15, Q8R1B6	Gene names	Ddx25, Grth
Domain Architecture
Description	ATP-dependent RNA helicase DDX25 (EC 3.6.1.-) (DEAD box protein 25) (Gonadotropin-regulated testicular RNA helicase).

DDX1_MOUSE
NC score	0.870999 (rank : 67)	θ value	3.75424e-22 (rank : 56)
Query Neighborhood Hits	190	Target Neighborhood Hits	112	Shared Neighborhood Hits	84
SwissProt Accessions	Q91VR5, Q3TU41	Gene names	Ddx1
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1).

DDX1_HUMAN
NC score	0.869761 (rank : 68)	θ value	1.09232e-21 (rank : 58)
Query Neighborhood Hits	190	Target Neighborhood Hits	110	Shared Neighborhood Hits	84
SwissProt Accessions	Q92499	Gene names	DDX1
Domain Architecture
Description	ATP-dependent RNA helicase DDX1 (EC 3.6.1.-) (DEAD box protein 1) (DEAD box protein retinoblastoma) (DBP-RB).

RECQ4_HUMAN
NC score	0.526881 (rank : 69)	θ value	0.0193708 (rank : 78)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	87
SwissProt Accessions	O94761, Q3Y424, Q96DW2, Q96F55	Gene names	RECQL4, RECQ4
Domain Architecture
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4) (RecQ4) (RTS).

RECQ4_MOUSE
NC score	0.510439 (rank : 70)	θ value	0.0113563 (rank : 77)
Query Neighborhood Hits	190	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	Q75NR7, Q76MT1, Q99PV9	Gene names	Recql4, Recq4
Domain Architecture	No domain graphic available
Description	ATP-dependent DNA helicase Q4 (EC 3.6.1.-) (RecQ protein-like 4).

BLM_MOUSE
NC score	0.484691 (rank : 71)	θ value	0.00665767 (rank : 75)
Query Neighborhood Hits	190	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	O88700, O88198	Gene names	Blm
Domain Architecture
Description	Bloom syndrome protein homolog (EC 3.6.1.-) (mBLM).

BLM_HUMAN
NC score	0.473534 (rank : 72)	θ value	0.00509761 (rank : 74)
Query Neighborhood Hits	190	Target Neighborhood Hits	148	Shared Neighborhood Hits	77
SwissProt Accessions	P54132	Gene names	BLM, RECQ2, RECQL3
Domain Architecture
Description	Bloom syndrome protein (EC 3.6.1.-) (RecQ protein-like 3) (DNA helicase, RecQ-like type 2).

WRN_HUMAN
NC score	0.468722 (rank : 73)	θ value	8.40245e-06 (rank : 69)
Query Neighborhood Hits	190	Target Neighborhood Hits	132	Shared Neighborhood Hits	83
SwissProt Accessions	Q14191	Gene names	WRN, RECQ3, RECQL2
Domain Architecture
Description	Werner syndrome ATP-dependent helicase (EC 3.6.1.-).

RECQ1_MOUSE
NC score	0.434389 (rank : 74)	θ value	0.000121331 (rank : 70)
Query Neighborhood Hits	190	Target Neighborhood Hits	95	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z129, Q9Z128	Gene names	Recql, Recql1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

RECQ5_HUMAN
NC score	0.430230 (rank : 75)	θ value	8.99809 (rank : 188)
Query Neighborhood Hits	190	Target Neighborhood Hits	390	Shared Neighborhood Hits	90
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RECQ1_HUMAN
NC score	0.429340 (rank : 76)	θ value	0.00869519 (rank : 76)
Query Neighborhood Hits	190	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	P46063	Gene names	RECQL, RECQL1
Domain Architecture
Description	ATP-dependent DNA helicase Q1 (EC 3.6.1.-) (DNA-dependent ATPase Q1).

WRN_MOUSE
NC score	0.429309 (rank : 77)	θ value	0.00102713 (rank : 73)
Query Neighborhood Hits	190	Target Neighborhood Hits	295	Shared Neighborhood Hits	88
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

FANCM_HUMAN
NC score	0.407673 (rank : 78)	θ value	0.0563607 (rank : 80)
Query Neighborhood Hits	190	Target Neighborhood Hits	210	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
NC score	0.404540 (rank : 79)	θ value	0.0736092 (rank : 82)
Query Neighborhood Hits	190	Target Neighborhood Hits	177	Shared Neighborhood Hits	81
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

DICER_HUMAN
NC score	0.402072 (rank : 80)	θ value	0.00102713 (rank : 71)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPY3, O95943, Q9UQ02	Gene names	DICER1, DICER, HERNA, KIAA0928
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Helicase with RNase motif) (Helicase-MOI).

DICER_MOUSE
NC score	0.401518 (rank : 81)	θ value	0.00102713 (rank : 72)
Query Neighborhood Hits	190	Target Neighborhood Hits	140	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R418	Gene names	Dicer1, Dicer, Mdcr
Domain Architecture
Description	Endoribonuclease Dicer (EC 3.1.26.-) (Double-strand-specific ribonuclease mDCR-1).

IFIH1_HUMAN
NC score	0.302618 (rank : 82)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	190	Target Neighborhood Hits	96	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BYX4, Q6DC96, Q86X56, Q96MX8, Q9H3G6	Gene names	IFIH1, MDA5, RH116
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon-induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5) (RNA helicase-DEAD box protein 116) (Murabutide-down- regulated protein).

LGP2_MOUSE
NC score	0.296520 (rank : 83)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	70
SwissProt Accessions	Q99J87, Q9D1X4	Gene names	Lgp2, D11lgp2e
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2).

IFIH1_MOUSE
NC score	0.291840 (rank : 84)	θ value	0.21417 (rank : 87)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	Q8R5F7, Q3U6S2, Q68EM4, Q8BYC9, Q8BZ01, Q8K5C7, Q8R144, Q8VE79, Q99KS4, Q9D2Z5	Gene names	Ifih1
Domain Architecture	No domain graphic available
Description	Interferon-induced helicase C domain-containing protein 1 (EC 3.6.1.-) (Interferon induced with helicase C domain protein 1) (Helicase with 2 CARD domains) (Helicard) (Melanoma differentiation-associated protein 5) (MDA-5).

LGP2_HUMAN
NC score	0.288408 (rank : 85)	θ value	6.88961 (rank : 164)
Query Neighborhood Hits	190	Target Neighborhood Hits	94	Shared Neighborhood Hits	71
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

DDX58_MOUSE
NC score	0.184295 (rank : 86)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	190	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_HUMAN
NC score	0.162077 (rank : 87)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	190	Target Neighborhood Hits	39	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BQ75	Gene names	C3orf26
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26.

DDX58_HUMAN
NC score	0.153440 (rank : 88)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	190	Target Neighborhood Hits	105	Shared Neighborhood Hits	55
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

CC026_MOUSE
NC score	0.147605 (rank : 89)	θ value	0.163984 (rank : 83)
Query Neighborhood Hits	190	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZT6, Q9CY77	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf26 homolog.

U520_HUMAN
NC score	0.131961 (rank : 90)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	44
SwissProt Accessions	O75643, O94884, Q6PX59, Q96IF2, Q9H7S0	Gene names	ASCC3L1, HELIC2, KIAA0788
Domain Architecture	No domain graphic available
Description	U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.1.-) (U5 snRNP-specific 200 kDa protein) (U5-200KD) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog).

HELC1_HUMAN
NC score	0.089487 (rank : 91)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	190	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N3C0, O43738, Q9H1I9, Q9NTR0	Gene names	ASCC3, HELIC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 3 (EC 3.6.1.-) (ASC-1 complex subunit p200) (Trip4 complex subunit p200) (Helicase, ATP binding 1).

SMAL1_HUMAN
NC score	0.073053 (rank : 92)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	190	Target Neighborhood Hits	174	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZC9, Q96AY1, Q9NXQ5, Q9UFH3, Q9UI93	Gene names	SMARCAL1, HARP
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (hHARP).

PHF20_MOUSE
NC score	0.044000 (rank : 93)	θ value	1.81305 (rank : 116)
Query Neighborhood Hits	190	Target Neighborhood Hits	513	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BLG0, Q8BMA2, Q8BYR4, Q921N1	Gene names	Phf20, Hca58
Domain Architecture
Description	PHD finger protein 20 (Hepatocellular carcinoma-associated antigen 58 homolog).

NIPBL_HUMAN
NC score	0.042207 (rank : 94)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	190	Target Neighborhood Hits	1311	Shared Neighborhood Hits	53
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

LEO1_MOUSE
NC score	0.036268 (rank : 95)	θ value	6.88961 (rank : 163)
Query Neighborhood Hits	190	Target Neighborhood Hits	946	Shared Neighborhood Hits	59
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TTC16_HUMAN
NC score	0.034128 (rank : 96)	θ value	0.0252991 (rank : 79)
Query Neighborhood Hits	190	Target Neighborhood Hits	417	Shared Neighborhood Hits	27
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

GP149_MOUSE
NC score	0.031580 (rank : 97)	θ value	0.21417 (rank : 86)
Query Neighborhood Hits	190	Target Neighborhood Hits	61	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UVY1, Q3TMB1, Q80T52, Q8BXA3, Q8BZC0	Gene names	Gpr149, Pgr10
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10).

IWS1_HUMAN
NC score	0.029609 (rank : 98)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	190	Target Neighborhood Hits	1241	Shared Neighborhood Hits	64
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

GP149_HUMAN
NC score	0.027558 (rank : 99)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	190	Target Neighborhood Hits	68	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SP6	Gene names	GPR149, PGR10
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 149 (G-protein coupled receptor PGR10).

RBBP6_MOUSE
NC score	0.026728 (rank : 100)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	190	Target Neighborhood Hits	1014	Shared Neighborhood Hits	53
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

NKTR_HUMAN
NC score	0.024441 (rank : 101)	θ value	5.27518 (rank : 153)
Query Neighborhood Hits	190	Target Neighborhood Hits	658	Shared Neighborhood Hits	51
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

APTX_MOUSE
NC score	0.023730 (rank : 102)	θ value	0.279714 (rank : 88)
Query Neighborhood Hits	190	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC5, Q8BPA7, Q8C2B5, Q8K3D1, Q9CQ59	Gene names	Aptx
Domain Architecture
Description	Aprataxin homolog (Forkhead-associated domain histidine triad-like protein) (FHA-HIT).

TRDN_HUMAN
NC score	0.023519 (rank : 103)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	190	Target Neighborhood Hits	542	Shared Neighborhood Hits	35
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

ESCO1_HUMAN
NC score	0.023330 (rank : 104)	θ value	2.36792 (rank : 123)
Query Neighborhood Hits	190	Target Neighborhood Hits	361	Shared Neighborhood Hits	21
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

ATRX_HUMAN
NC score	0.021859 (rank : 105)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	190	Target Neighborhood Hits	842	Shared Neighborhood Hits	51
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

PALM_MOUSE
NC score	0.021184 (rank : 106)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	190	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

MINT_MOUSE
NC score	0.019584 (rank : 107)	θ value	1.81305 (rank : 115)
Query Neighborhood Hits	190	Target Neighborhood Hits	1514	Shared Neighborhood Hits	55
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ARMX2_HUMAN
NC score	0.019376 (rank : 108)	θ value	0.0736092 (rank : 81)
Query Neighborhood Hits	190	Target Neighborhood Hits	134	Shared Neighborhood Hits	6
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

CJ012_HUMAN
NC score	0.018964 (rank : 109)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	190	Target Neighborhood Hits	467	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

PININ_MOUSE
NC score	0.018706 (rank : 110)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	190	Target Neighborhood Hits	777	Shared Neighborhood Hits	38
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

TCOF_MOUSE
NC score	0.018132 (rank : 111)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	190	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

GTSE1_MOUSE
NC score	0.017971 (rank : 112)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	190	Target Neighborhood Hits	245	Shared Neighborhood Hits	10
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

SIAL_MOUSE
NC score	0.017722 (rank : 113)	θ value	3.0926 (rank : 132)
Query Neighborhood Hits	190	Target Neighborhood Hits	69	Shared Neighborhood Hits	9
SwissProt Accessions	Q61711, Q61363	Gene names	Ibsp
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

TAI12_MOUSE
NC score	0.017261 (rank : 114)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	190	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGQ2, Q3UIH1	Gene names	Taip12
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

GPTC8_HUMAN
NC score	0.016768 (rank : 115)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	190	Target Neighborhood Hits	366	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

TMCO3_HUMAN
NC score	0.016490 (rank : 116)	θ value	0.62314 (rank : 96)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q6UWJ1, Q5JSB1, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2	Gene names	TMCO3, C13orf11
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor (Putative LAG1-interacting protein).

CG1_HUMAN
NC score	0.016097 (rank : 117)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	190	Target Neighborhood Hits	222	Shared Neighborhood Hits	15
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

RBBP8_HUMAN
NC score	0.016052 (rank : 118)	θ value	2.36792 (rank : 125)
Query Neighborhood Hits	190	Target Neighborhood Hits	476	Shared Neighborhood Hits	19
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

NCKX1_HUMAN
NC score	0.015616 (rank : 119)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	190	Target Neighborhood Hits	223	Shared Neighborhood Hits	13
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

MINT_HUMAN
NC score	0.015133 (rank : 120)	θ value	6.88961 (rank : 166)
Query Neighborhood Hits	190	Target Neighborhood Hits	1291	Shared Neighborhood Hits	54
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

T22D3_HUMAN
NC score	0.015060 (rank : 121)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	190	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q99576, Q6FIH6, Q8NAI1, Q8WVB9, Q9UBN5, Q9UG13	Gene names	TSC22D3, DSIPI, GILZ
Domain Architecture
Description	TSC22 domain family protein 3 (Glucocorticoid-induced leucine zipper protein) (Delta sleep-inducing peptide immunoreactor) (DSIP- immunoreactive peptide) (Protein DIP) (hDIP) (TSC-22-like protein) (TSC-22R).

TAI12_HUMAN
NC score	0.014513 (rank : 122)	θ value	3.0926 (rank : 134)
Query Neighborhood Hits	190	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H175	Gene names	TAIP12, C12orf22
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 12 (TAIP-12).

RSF1_HUMAN
NC score	0.014233 (rank : 123)	θ value	3.0926 (rank : 131)
Query Neighborhood Hits	190	Target Neighborhood Hits	539	Shared Neighborhood Hits	32
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

MO4L2_MOUSE
NC score	0.013761 (rank : 124)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	190	Target Neighborhood Hits	86	Shared Neighborhood Hits	9
SwissProt Accessions	Q9R0Q4, Q3UL62, Q6DIB1, Q6ZQK7, Q8C201, Q8C6C2	Gene names	Morf4l2, Kiaa0026, Sid393
Domain Architecture	No domain graphic available
Description	Mortality factor 4-like protein 2 (MORF-related gene X protein) (Transcription factor-like protein MRGX) (Sid 393).

TAF4_HUMAN
NC score	0.013133 (rank : 125)	θ value	1.81305 (rank : 118)
Query Neighborhood Hits	190	Target Neighborhood Hits	687	Shared Neighborhood Hits	19
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

CHD8_HUMAN
NC score	0.013090 (rank : 126)	θ value	1.38821 (rank : 108)
Query Neighborhood Hits	190	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HCK8, Q68DQ0, Q8N3Z9, Q8NCY4, Q8TBR9, Q96F26	Gene names	CHD8, HELSNF1, KIAA1564
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 8 (EC 3.6.1.-) (ATP- dependent helicase CHD8) (CHD-8) (Helicase with SNF2 domain 1).

NFH_MOUSE
NC score	0.012796 (rank : 127)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	190	Target Neighborhood Hits	2247	Shared Neighborhood Hits	81
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ARNT2_MOUSE
NC score	0.012441 (rank : 128)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	190	Target Neighborhood Hits	115	Shared Neighborhood Hits	6
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

CCDC4_HUMAN
NC score	0.012400 (rank : 129)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	190	Target Neighborhood Hits	104	Shared Neighborhood Hits	4
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

ATRX_MOUSE
NC score	0.012339 (rank : 130)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	190	Target Neighborhood Hits	682	Shared Neighborhood Hits	39
SwissProt Accessions	Q61687	Gene names	Atrx, Hp1bp2, Xnp
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked nuclear protein) (Heterochromatin protein 2) (HP1 alpha-interacting protein) (HP1-BP38 protein).

ARNT2_HUMAN
NC score	0.012311 (rank : 131)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	190	Target Neighborhood Hits	109	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ABTAP_HUMAN
NC score	0.011854 (rank : 132)	θ value	1.81305 (rank : 113)
Query Neighborhood Hits	190	Target Neighborhood Hits	290	Shared Neighborhood Hits	15
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

DIDO1_HUMAN
NC score	0.011607 (rank : 133)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	190	Target Neighborhood Hits	960	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GSLG1_HUMAN
NC score	0.011515 (rank : 134)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	190	Target Neighborhood Hits	39	Shared Neighborhood Hits	4
SwissProt Accessions	Q92896, Q13221	Gene names	GLG1, CFR1, ESL1, MG160
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Cysteine-rich fibroblast growth factor receptor) (CFR-1).

GON4L_MOUSE
NC score	0.011255 (rank : 135)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	190	Target Neighborhood Hits	455	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

AKAP1_HUMAN
NC score	0.011229 (rank : 136)	θ value	2.36792 (rank : 120)
Query Neighborhood Hits	190	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q92667, Q13320, Q9BW14	Gene names	AKAP1, AKAP149
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein 84) (S-AKAP84).

CN092_MOUSE
NC score	0.010986 (rank : 137)	θ value	1.38821 (rank : 109)
Query Neighborhood Hits	190	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BU11, Q80UI2, Q99PN9, Q9CS16	Gene names
Domain Architecture
Description	Epidermal Langerhans cell protein LCP1.

GSLG1_MOUSE
NC score	0.010860 (rank : 138)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	190	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q61543, Q9QZ40	Gene names	Glg1, Esl1, Mg160, Selel
Domain Architecture
Description	Golgi apparatus protein 1 precursor (Golgi sialoglycoprotein MG-160) (E-selectin ligand 1) (ESL-1) (Selel).

PELP1_HUMAN
NC score	0.010428 (rank : 139)	θ value	3.0926 (rank : 130)
Query Neighborhood Hits	190	Target Neighborhood Hits	596	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

NU214_HUMAN
NC score	0.010327 (rank : 140)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	190	Target Neighborhood Hits	657	Shared Neighborhood Hits	21
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

FA47B_HUMAN
NC score	0.010072 (rank : 141)	θ value	1.81305 (rank : 114)
Query Neighborhood Hits	190	Target Neighborhood Hits	431	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

BAZ1B_HUMAN
NC score	0.010066 (rank : 142)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	190	Target Neighborhood Hits	701	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

AFF2_HUMAN
NC score	0.010028 (rank : 143)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	190	Target Neighborhood Hits	218	Shared Neighborhood Hits	15
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

UBP10_MOUSE
NC score	0.009318 (rank : 144)	θ value	1.81305 (rank : 119)
Query Neighborhood Hits	190	Target Neighborhood Hits	150	Shared Neighborhood Hits	10
SwissProt Accessions	P52479, Q91VY7	Gene names	Usp10, Ode-1, Uchrp
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.1.2.15) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) (Deubiquitinating enzyme 10).

OS9_HUMAN
NC score	0.009152 (rank : 145)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	190	Target Neighborhood Hits	134	Shared Neighborhood Hits	13
SwissProt Accessions	Q13438, O00579	Gene names	OS9
Domain Architecture	No domain graphic available
Description	Protein OS-9 precursor (Amplified in osteosarcoma 9).

MADCA_HUMAN
NC score	0.008900 (rank : 146)	θ value	6.88961 (rank : 165)
Query Neighborhood Hits	190	Target Neighborhood Hits	221	Shared Neighborhood Hits	13
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

TISD_HUMAN
NC score	0.008772 (rank : 147)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	190	Target Neighborhood Hits	78	Shared Neighborhood Hits	3
SwissProt Accessions	P47974, Q9BSJ3	Gene names	ZFP36L2, BRF2, ERF2, TIS11D
Domain Architecture
Description	Butyrate response factor 2 (TIS11D protein) (EGF-response factor 2) (ERF-2).

ST5_MOUSE
NC score	0.008560 (rank : 148)	θ value	2.36792 (rank : 126)
Query Neighborhood Hits	190	Target Neighborhood Hits	126	Shared Neighborhood Hits	8
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

PLCB2_HUMAN
NC score	0.008514 (rank : 149)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	190	Target Neighborhood Hits	608	Shared Neighborhood Hits	20
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

SET1A_HUMAN
NC score	0.008194 (rank : 150)	θ value	5.27518 (rank : 154)
Query Neighborhood Hits	190	Target Neighborhood Hits	690	Shared Neighborhood Hits	31
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

GOGA4_HUMAN
NC score	0.008145 (rank : 151)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	190	Target Neighborhood Hits	2034	Shared Neighborhood Hits	56
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

EP400_MOUSE
NC score	0.008102 (rank : 152)	θ value	2.36792 (rank : 122)
Query Neighborhood Hits	190	Target Neighborhood Hits	592	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

NFH_HUMAN
NC score	0.008061 (rank : 153)	θ value	2.36792 (rank : 124)
Query Neighborhood Hits	190	Target Neighborhood Hits	1242	Shared Neighborhood Hits	51
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ST5_HUMAN
NC score	0.008033 (rank : 154)	θ value	5.27518 (rank : 155)
Query Neighborhood Hits	190	Target Neighborhood Hits	151	Shared Neighborhood Hits	7
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

CTR9_MOUSE
NC score	0.007902 (rank : 155)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	190	Target Neighborhood Hits	427	Shared Neighborhood Hits	25
SwissProt Accessions	Q62018, Q3UFF5, Q3UY40, Q66JX4, Q7TPS6, Q8BND9, Q8BRD1, Q8C9W7, Q8C9Y3, Q8CHI1	Gene names	Ctr9, Kiaa0155, Sh2bp1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1) (Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa) (TPR-containing, SH2-binding phosphoprotein of 150 kDa) (p150TSP).

PCLO_MOUSE
NC score	0.007782 (rank : 156)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	190	Target Neighborhood Hits	2275	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SRBP1_MOUSE
NC score	0.007614 (rank : 157)	θ value	3.0926 (rank : 133)
Query Neighborhood Hits	190	Target Neighborhood Hits	384	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

AP3B1_HUMAN
NC score	0.007594 (rank : 158)	θ value	3.0926 (rank : 129)
Query Neighborhood Hits	190	Target Neighborhood Hits	283	Shared Neighborhood Hits	17
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

NEST_HUMAN
NC score	0.006380 (rank : 159)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	190	Target Neighborhood Hits	1305	Shared Neighborhood Hits	45
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

TRPS1_MOUSE
NC score	0.006326 (rank : 160)	θ value	2.36792 (rank : 127)
Query Neighborhood Hits	190	Target Neighborhood Hits	609	Shared Neighborhood Hits	16
SwissProt Accessions	Q925H1	Gene names	Trps1
Domain Architecture
Description	Zinc finger transcription factor Trps1.

BRD2_HUMAN
NC score	0.005965 (rank : 161)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	190	Target Neighborhood Hits	242	Shared Neighborhood Hits	15
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

TACC2_MOUSE
NC score	0.005752 (rank : 162)	θ value	1.81305 (rank : 117)
Query Neighborhood Hits	190	Target Neighborhood Hits	774	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ASTL_HUMAN
NC score	0.005390 (rank : 163)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	190	Target Neighborhood Hits	252	Shared Neighborhood Hits	12
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

SEL1L_MOUSE
NC score	0.004822 (rank : 164)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	190	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

CPSF7_HUMAN
NC score	0.004604 (rank : 165)	θ value	8.99809 (rank : 176)
Query Neighborhood Hits	190	Target Neighborhood Hits	125	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N684, Q7Z3H9, Q9H025, Q9H9V1	Gene names	CPSF7
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Pre-mRNA cleavage factor Im 59 kDa subunit).

CCD41_HUMAN
NC score	0.004482 (rank : 166)	θ value	0.62314 (rank : 92)
Query Neighborhood Hits	190	Target Neighborhood Hits	1139	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

JHD3C_MOUSE
NC score	0.003704 (rank : 167)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	190	Target Neighborhood Hits	84	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VCD7, Q3UNP7, Q69ZZ5, Q8BUY6, Q8BWA1	Gene names	Jmjd2c, Jhdm3c, Kiaa0780
Domain Architecture
Description	JmjC domain-containing histone demethylation protein 3C (EC 1.14.11.-) (Jumonji domain-containing protein 2C).

SEPT9_MOUSE
NC score	0.003294 (rank : 168)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	190	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q80UG5, Q3URP2, Q80TM7, Q9QYX9	Gene names	Sept9, Kiaa0991, Sint1
Domain Architecture	No domain graphic available
Description	Septin-9 (SL3-3 integration site 1 protein).

ANK3_HUMAN
NC score	0.002995 (rank : 169)	θ value	0.62314 (rank : 91)
Query Neighborhood Hits	190	Target Neighborhood Hits	853	Shared Neighborhood Hits	37
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

MCF2L_MOUSE
NC score	0.002918 (rank : 170)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	190	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

CCD96_MOUSE
NC score	0.002773 (rank : 171)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	190	Target Neighborhood Hits	704	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

PYGM_MOUSE
NC score	0.002716 (rank : 172)	θ value	8.99809 (rank : 187)
Query Neighborhood Hits	190	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WUB3	Gene names	Pygm
Domain Architecture
Description	Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase).

DZIP1_MOUSE
NC score	0.002697 (rank : 173)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	190	Target Neighborhood Hits	530	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

NEBL_HUMAN
NC score	0.002090 (rank : 174)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	190	Target Neighborhood Hits	457	Shared Neighborhood Hits	16
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

MYPT1_MOUSE
NC score	0.000895 (rank : 175)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	190	Target Neighborhood Hits	539	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

MYH11_MOUSE
NC score	0.000665 (rank : 176)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	190	Target Neighborhood Hits	1777	Shared Neighborhood Hits	46
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CD2L1_HUMAN
NC score	0.000664 (rank : 177)	θ value	0.21417 (rank : 84)
Query Neighborhood Hits	190	Target Neighborhood Hits	1467	Shared Neighborhood Hits	35
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
NC score	0.000456 (rank : 178)	θ value	0.21417 (rank : 85)
Query Neighborhood Hits	190	Target Neighborhood Hits	1463	Shared Neighborhood Hits	35
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

TXLNG_MOUSE
NC score	0.000142 (rank : 179)	θ value	8.99809 (rank : 189)
Query Neighborhood Hits	190	Target Neighborhood Hits	552	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

CD2L2_HUMAN
NC score	0.000034 (rank : 180)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	190	Target Neighborhood Hits	1439	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

MP2K7_HUMAN
NC score	-0.000278 (rank : 181)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	190	Target Neighborhood Hits	833	Shared Neighborhood Hits	11
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

ARX_HUMAN
NC score	-0.000486 (rank : 182)	θ value	2.36792 (rank : 121)
Query Neighborhood Hits	190	Target Neighborhood Hits	401	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

EHMT1_HUMAN
NC score	-0.000527 (rank : 183)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	190	Target Neighborhood Hits	417	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

ARX_MOUSE
NC score	-0.001046 (rank : 184)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	190	Target Neighborhood Hits	398	Shared Neighborhood Hits	5
SwissProt Accessions	O35085, Q9QYT4	Gene names	Arx
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

MRCKB_MOUSE
NC score	-0.001561 (rank : 185)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	190	Target Neighborhood Hits	2180	Shared Neighborhood Hits	43
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NCA11_MOUSE
NC score	-0.001860 (rank : 186)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	190	Target Neighborhood Hits	661	Shared Neighborhood Hits	17
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ANR26_MOUSE
NC score	-0.002275 (rank : 187)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	190	Target Neighborhood Hits	1554	Shared Neighborhood Hits	40
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

WEE1B_HUMAN
NC score	-0.002438 (rank : 188)	θ value	8.99809 (rank : 190)
Query Neighborhood Hits	190	Target Neighborhood Hits	836	Shared Neighborhood Hits	21
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

CSPG2_HUMAN
NC score	-0.003157 (rank : 189)	θ value	8.99809 (rank : 177)
Query Neighborhood Hits	190	Target Neighborhood Hits	681	Shared Neighborhood Hits	9
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

MK15_MOUSE
NC score	-0.003339 (rank : 190)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	190	Target Neighborhood Hits	843	Shared Neighborhood Hits	12
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

STK33_HUMAN
NC score	-0.004346 (rank : 191)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	190	Target Neighborhood Hits	879	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

MYLK2_HUMAN
NC score	-0.004578 (rank : 192)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	190	Target Neighborhood Hits	920	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

ZBTB3_HUMAN
NC score	-0.004737 (rank : 193)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	190	Target Neighborhood Hits	910	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H5J0	Gene names	ZBTB3
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 3.

TCF8_MOUSE
NC score	-0.005772 (rank : 194)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	190	Target Neighborhood Hits	1067	Shared Neighborhood Hits	21
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZN142_HUMAN
NC score	-0.006429 (rank : 195)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	190	Target Neighborhood Hits	1007	Shared Neighborhood Hits	17
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZBT17_MOUSE
NC score	-0.007317 (rank : 196)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	190	Target Neighborhood Hits	940	Shared Neighborhood Hits	15
SwissProt Accessions	Q60821, Q60699	Gene names	Zbtb17, Zfp100, Znf151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Zinc finger protein 100) (Zfp-100) (Polyomavirus late initiator promoter-binding protein) (LP-1) (Zinc finger protein Z13).