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Network neighborhood for query Sequence : ARNT2_HUMAN

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ARNT2_HUMAN
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARNT2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0 (rank : 2)	NC score	0.997952 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	96
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	0 (rank : 3)	NC score	0.988031 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0 (rank : 4)	NC score	0.973755 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	213	Shared Neighborhood Hits	80
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BMAL1_HUMAN
θ value	1.49618e-87 (rank : 5)	NC score	0.941435 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	4.81303e-86 (rank : 6)	NC score	0.939666 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

EPAS1_MOUSE
θ value	8.91499e-32 (rank : 7)	NC score	0.794139 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

EPAS1_HUMAN
θ value	1.28732e-30 (rank : 8)	NC score	0.794169 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

HIF1A_HUMAN
θ value	4.28545e-26 (rank : 9)	NC score	0.780297 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	7.30988e-26 (rank : 10)	NC score	0.781496 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM2_HUMAN
θ value	2.77775e-25 (rank : 11)	NC score	0.748487 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

NPAS2_MOUSE
θ value	3.62785e-25 (rank : 12)	NC score	0.792269 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	60
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
θ value	4.73814e-25 (rank : 13)	NC score	0.792793 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	150	Shared Neighborhood Hits	58
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

SIM1_HUMAN
θ value	6.18819e-25 (rank : 14)	NC score	0.753431 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	62	Shared Neighborhood Hits	42
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	1.80048e-24 (rank : 15)	NC score	0.752354 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

CLOCK_MOUSE
θ value	2.35151e-24 (rank : 16)	NC score	0.796005 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	61
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

SIM2_MOUSE
θ value	1.16704e-23 (rank : 17)	NC score	0.747697 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	41
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

CLOCK_HUMAN
θ value	1.99067e-23 (rank : 18)	NC score	0.795088 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

NPAS3_MOUSE
θ value	1.92812e-18 (rank : 19)	NC score	0.709201 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	4.02038e-16 (rank : 20)	NC score	0.702335 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NCOA3_HUMAN
θ value	5.8054e-15 (rank : 21)	NC score	0.574792 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA1_MOUSE
θ value	7.58209e-15 (rank : 22)	NC score	0.610070 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	196	Shared Neighborhood Hits	45
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	1.29331e-14 (rank : 23)	NC score	0.606035 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NPAS1_MOUSE
θ value	2.43908e-13 (rank : 24)	NC score	0.687367 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

PER2_HUMAN
θ value	1.2105e-12 (rank : 25)	NC score	0.480668 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	1.58096e-12 (rank : 26)	NC score	0.450535 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	325	Shared Neighborhood Hits	29
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

NCOA3_MOUSE
θ value	2.69671e-12 (rank : 27)	NC score	0.536153 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	203	Shared Neighborhood Hits	35
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS1_HUMAN
θ value	2.69671e-12 (rank : 28)	NC score	0.682830 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

PER3_HUMAN
θ value	6.00763e-12 (rank : 29)	NC score	0.454048 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	479	Shared Neighborhood Hits	35
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER1_HUMAN
θ value	1.33837e-11 (rank : 30)	NC score	0.472369 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	215	Shared Neighborhood Hits	31
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	1.33837e-11 (rank : 31)	NC score	0.469361 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

AHR_HUMAN
θ value	2.52405e-10 (rank : 32)	NC score	0.665594 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

PER3_MOUSE
θ value	3.29651e-10 (rank : 33)	NC score	0.488706 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

AHR_MOUSE
θ value	1.06045e-08 (rank : 34)	NC score	0.650743 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA2_HUMAN
θ value	2.36244e-08 (rank : 35)	NC score	0.523514 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	4.0297e-08 (rank : 36)	NC score	0.524576 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NPAS4_HUMAN
θ value	2.44474e-05 (rank : 37)	NC score	0.506727 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

USF2_HUMAN
θ value	0.000602161 (rank : 38)	NC score	0.258175 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF1_HUMAN
θ value	0.000786445 (rank : 39)	NC score	0.266239 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.000786445 (rank : 40)	NC score	0.266360 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
θ value	0.00102713 (rank : 41)	NC score	0.249221 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	173	Shared Neighborhood Hits	45
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MYCL1_MOUSE
θ value	0.00175202 (rank : 42)	NC score	0.187568 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	41
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HEY2_HUMAN
θ value	0.00298849 (rank : 43)	NC score	0.231516 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	0.00298849 (rank : 44)	NC score	0.228539 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MYCL1_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.181403 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

TFE3_HUMAN
θ value	0.00665767 (rank : 46)	NC score	0.239068 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

NPAS4_MOUSE
θ value	0.00869519 (rank : 47)	NC score	0.486745 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

TFEB_HUMAN
θ value	0.00869519 (rank : 48)	NC score	0.231643 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	44
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	0.00869519 (rank : 49)	NC score	0.231682 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MITF_MOUSE
θ value	0.0113563 (rank : 50)	NC score	0.233568 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
θ value	0.0431538 (rank : 51)	NC score	0.226931 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HEY1_HUMAN
θ value	0.0736092 (rank : 52)	NC score	0.199901 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	0.0736092 (rank : 53)	NC score	0.206920 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

OGFR_HUMAN
θ value	0.0961366 (rank : 54)	NC score	0.023051 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	1582	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MAX_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.175265 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	39
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MYCN_HUMAN
θ value	0.21417 (rank : 56)	NC score	0.127967 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.124522 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
θ value	0.21417 (rank : 58)	NC score	0.122023 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAD4_HUMAN
θ value	0.279714 (rank : 59)	NC score	0.123502 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

SRBP1_HUMAN
θ value	0.279714 (rank : 60)	NC score	0.152408 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ZN485_HUMAN
θ value	0.365318 (rank : 61)	NC score	-0.001385 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	744	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NCK3, Q96CL0	Gene names	ZNF485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 485.

ATF7_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.032856 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	333	Shared Neighborhood Hits	7
SwissProt Accessions	P17544, Q13814	Gene names	ATF7, ATFA
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-7 (Activating transcription factor 7) (Transcription factor ATF-A).

ATF7_MOUSE
θ value	0.47712 (rank : 63)	NC score	0.035257 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0S1	Gene names	Atf7
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-7 (Activating transcription factor 7) (Transcription factor ATF-A).

MAX_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.164592 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	38
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

TCFL5_HUMAN
θ value	0.47712 (rank : 65)	NC score	0.183829 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

BACH_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.039160 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V12, Q59HQ2	Gene names	Acot7, Bach
Domain Architecture
Description	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Long chain acyl-CoA thioester hydrolase) (CTE-II) (CTE-IIa) (Brain acyl-CoA hydrolase) (Acyl-CoA thioesterase 7).

MYC_HUMAN
θ value	0.62314 (rank : 67)	NC score	0.121606 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

PLEC1_HUMAN
θ value	0.62314 (rank : 68)	NC score	0.004750 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	1326	Shared Neighborhood Hits	10
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

DDX24_HUMAN
θ value	0.813845 (rank : 69)	NC score	0.012311 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

MYCS_MOUSE
θ value	0.813845 (rank : 70)	NC score	0.123886 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

CDSN_MOUSE
θ value	1.06291 (rank : 71)	NC score	0.024133 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

SRBP1_MOUSE
θ value	1.06291 (rank : 72)	NC score	0.133967 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	384	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BHLH2_HUMAN
θ value	1.38821 (rank : 73)	NC score	0.120513 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	1.38821 (rank : 74)	NC score	0.120346 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	37
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

EPHA1_HUMAN
θ value	1.38821 (rank : 75)	NC score	-0.001445 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	997	Shared Neighborhood Hits	6
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

SRBP2_HUMAN
θ value	1.38821 (rank : 76)	NC score	0.124403 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	44
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

PLCD1_MOUSE
θ value	1.81305 (rank : 77)	NC score	0.015555 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

BHLH3_HUMAN
θ value	2.36792 (rank : 78)	NC score	0.126356 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	2.36792 (rank : 79)	NC score	0.124663 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

CASL_HUMAN
θ value	2.36792 (rank : 80)	NC score	0.013827 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

HAND1_MOUSE
θ value	2.36792 (rank : 81)	NC score	0.036191 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

UFO_HUMAN
θ value	3.0926 (rank : 82)	NC score	-0.002788 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	981	Shared Neighborhood Hits	5
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FHOD1_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.019206 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FHOD1_MOUSE
θ value	4.03905 (rank : 84)	NC score	0.018729 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

MAD3_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.072784 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

ALEX_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.015726 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	361	Shared Neighborhood Hits	9
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

EP300_HUMAN
θ value	5.27518 (rank : 87)	NC score	0.020886 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	821	Shared Neighborhood Hits	22
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

EPIPL_HUMAN
θ value	5.27518 (rank : 88)	NC score	0.014150 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

GAK_HUMAN
θ value	5.27518 (rank : 89)	NC score	-0.003192 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	1028	Shared Neighborhood Hits	6
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MLX_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.160457 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

ZN228_HUMAN
θ value	5.27518 (rank : 91)	NC score	-0.003024 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	775	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJU3, Q9HCA7	Gene names	ZNF228
Domain Architecture
Description	Zinc finger protein 228.

BSN_MOUSE
θ value	6.88961 (rank : 92)	NC score	0.020134 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	2057	Shared Neighborhood Hits	26
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CCNT1_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.008565 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QWV9, Q9Z0U7	Gene names	Ccnt1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

CTND2_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.008786 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CTND2_MOUSE
θ value	6.88961 (rank : 95)	NC score	0.007971 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

MLX_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.155168 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

NEDD1_MOUSE
θ value	6.88961 (rank : 97)	NC score	0.003201 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

PDE8A_MOUSE
θ value	6.88961 (rank : 98)	NC score	0.006986 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PODXL_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.024110 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	191	Shared Neighborhood Hits	8
SwissProt Accessions	O00592	Gene names	PODXL, PCLP, PCLP1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

R3HD2_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.022758 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	397	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RHES_MOUSE
θ value	6.88961 (rank : 101)	NC score	0.003081 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	P63032, Q9WVD3	Gene names	Rasd2
Domain Architecture	No domain graphic available
Description	GTP-binding protein Rhes (Ras homolog enriched in striatum).

APOA_HUMAN
θ value	8.99809 (rank : 102)	NC score	-0.000885 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

CO9A2_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.001206 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	261	Shared Neighborhood Hits	5
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

HES4_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.094545 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MAD1_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.052844 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

PDE8A_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.006031 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

RHES_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.002345 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q96D21, O95520, Q5THY8	Gene names	RASD2, TEM2
Domain Architecture
Description	GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2).

TAB2_MOUSE
θ value	8.99809 (rank : 108)	NC score	0.004967 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

ZNF7_HUMAN
θ value	8.99809 (rank : 109)	NC score	-0.003581 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	P17097, P17015	Gene names	ZNF7, KOX4
Domain Architecture
Description	Zinc finger protein 7 (Zinc finger protein KOX4) (Zinc finger protein HF.16).

HES1_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.073454 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.073803 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES3_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.064946 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.093902 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES7_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.061423 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.059284 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD4_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.050407 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	65	Shared Neighborhood Hits	21
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MNT_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.061011 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	496	Shared Neighborhood Hits	36
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.058052 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MXI1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.050549 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCL2_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.076119 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

Hits sorted by NC score

ARNT2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.997952 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	96
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.988031 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.973755 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	213	Shared Neighborhood Hits	80
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BMAL1_HUMAN
NC score	0.941435 (rank : 5)	θ value	1.49618e-87 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.939666 (rank : 6)	θ value	4.81303e-86 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	72
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_MOUSE
NC score	0.796005 (rank : 7)	θ value	2.35151e-24 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	61
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
NC score	0.795088 (rank : 8)	θ value	1.99067e-23 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

EPAS1_HUMAN
NC score	0.794169 (rank : 9)	θ value	1.28732e-30 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.794139 (rank : 10)	θ value	8.91499e-32 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

NPAS2_HUMAN
NC score	0.792793 (rank : 11)	θ value	4.73814e-25 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	150	Shared Neighborhood Hits	58
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.792269 (rank : 12)	θ value	3.62785e-25 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	60
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

HIF1A_MOUSE
NC score	0.781496 (rank : 13)	θ value	7.30988e-26 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.780297 (rank : 14)	θ value	4.28545e-26 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

SIM1_HUMAN
NC score	0.753431 (rank : 15)	θ value	6.18819e-25 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	62	Shared Neighborhood Hits	42
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.752354 (rank : 16)	θ value	1.80048e-24 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
NC score	0.748487 (rank : 17)	θ value	2.77775e-25 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	40
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.747697 (rank : 18)	θ value	1.16704e-23 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	41
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
NC score	0.709201 (rank : 19)	θ value	1.92812e-18 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.702335 (rank : 20)	θ value	4.02038e-16 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
NC score	0.687367 (rank : 21)	θ value	2.43908e-13 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.682830 (rank : 22)	θ value	2.69671e-12 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_HUMAN
NC score	0.665594 (rank : 23)	θ value	2.52405e-10 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.650743 (rank : 24)	θ value	1.06045e-08 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA1_MOUSE
NC score	0.610070 (rank : 25)	θ value	7.58209e-15 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	196	Shared Neighborhood Hits	45
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.606035 (rank : 26)	θ value	1.29331e-14 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.574792 (rank : 27)	θ value	5.8054e-15 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.536153 (rank : 28)	θ value	2.69671e-12 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	203	Shared Neighborhood Hits	35
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NCOA2_MOUSE
NC score	0.524576 (rank : 29)	θ value	4.0297e-08 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.523514 (rank : 30)	θ value	2.36244e-08 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	34
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS4_HUMAN
NC score	0.506727 (rank : 31)	θ value	2.44474e-05 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

PER3_MOUSE
NC score	0.488706 (rank : 32)	θ value	3.29651e-10 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

NPAS4_MOUSE
NC score	0.486745 (rank : 33)	θ value	0.00869519 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PER2_HUMAN
NC score	0.480668 (rank : 34)	θ value	1.2105e-12 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.472369 (rank : 35)	θ value	1.33837e-11 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	215	Shared Neighborhood Hits	31
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.469361 (rank : 36)	θ value	1.33837e-11 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.454048 (rank : 37)	θ value	6.00763e-12 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	479	Shared Neighborhood Hits	35
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.450535 (rank : 38)	θ value	1.58096e-12 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	325	Shared Neighborhood Hits	29
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

USF1_MOUSE
NC score	0.266360 (rank : 39)	θ value	0.000786445 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.266239 (rank : 40)	θ value	0.000786445 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.258175 (rank : 41)	θ value	0.000602161 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	155	Shared Neighborhood Hits	45
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.249221 (rank : 42)	θ value	0.00102713 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	173	Shared Neighborhood Hits	45
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

TFE3_HUMAN
NC score	0.239068 (rank : 43)	θ value	0.00665767 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_MOUSE
NC score	0.233568 (rank : 44)	θ value	0.0113563 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.231682 (rank : 45)	θ value	0.00869519 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.231643 (rank : 46)	θ value	0.00869519 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	44
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

HEY2_HUMAN
NC score	0.231516 (rank : 47)	θ value	0.00298849 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.228539 (rank : 48)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MITF_HUMAN
NC score	0.226931 (rank : 49)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HEY1_MOUSE
NC score	0.206920 (rank : 50)	θ value	0.0736092 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.199901 (rank : 51)	θ value	0.0736092 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	82	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MYCL1_MOUSE
NC score	0.187568 (rank : 52)	θ value	0.00175202 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	41
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

TCFL5_HUMAN
NC score	0.183829 (rank : 53)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MYCL1_HUMAN
NC score	0.181403 (rank : 54)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MAX_MOUSE
NC score	0.175265 (rank : 55)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	39
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.164592 (rank : 56)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	38
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MLX_MOUSE
NC score	0.160457 (rank : 57)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.155168 (rank : 58)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_HUMAN
NC score	0.152408 (rank : 59)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	225	Shared Neighborhood Hits	46
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.133967 (rank : 60)	θ value	1.06291 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	384	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCN_HUMAN
NC score	0.127967 (rank : 61)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

BHLH3_HUMAN
NC score	0.126356 (rank : 62)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.124663 (rank : 63)	θ value	2.36792 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

MYCN_MOUSE
NC score	0.124522 (rank : 64)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

SRBP2_HUMAN
NC score	0.124403 (rank : 65)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	44
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MYCS_MOUSE
NC score	0.123886 (rank : 66)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MAD4_HUMAN
NC score	0.123502 (rank : 67)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYC_MOUSE
NC score	0.122023 (rank : 68)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_HUMAN
NC score	0.121606 (rank : 69)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	35
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

BHLH2_HUMAN
NC score	0.120513 (rank : 70)	θ value	1.38821 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.120346 (rank : 71)	θ value	1.38821 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	37
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES4_HUMAN
NC score	0.094545 (rank : 72)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES5_MOUSE
NC score	0.093902 (rank : 73)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MYCL2_HUMAN
NC score	0.076119 (rank : 74)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

HES1_MOUSE
NC score	0.073803 (rank : 75)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.073454 (rank : 76)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

MAD3_HUMAN
NC score	0.072784 (rank : 77)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	34
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

HES3_MOUSE
NC score	0.064946 (rank : 78)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES7_HUMAN
NC score	0.061423 (rank : 79)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MNT_HUMAN
NC score	0.061011 (rank : 80)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	496	Shared Neighborhood Hits	36
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HES7_MOUSE
NC score	0.059284 (rank : 81)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MNT_MOUSE
NC score	0.058052 (rank : 82)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	432	Shared Neighborhood Hits	33
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MAD1_MOUSE
NC score	0.052844 (rank : 83)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MXI1_MOUSE
NC score	0.050549 (rank : 84)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_MOUSE
NC score	0.050407 (rank : 85)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	65	Shared Neighborhood Hits	21
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

BACH_MOUSE
NC score	0.039160 (rank : 86)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V12, Q59HQ2	Gene names	Acot7, Bach
Domain Architecture
Description	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Long chain acyl-CoA thioester hydrolase) (CTE-II) (CTE-IIa) (Brain acyl-CoA hydrolase) (Acyl-CoA thioesterase 7).

HAND1_MOUSE
NC score	0.036191 (rank : 87)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

ATF7_MOUSE
NC score	0.035257 (rank : 88)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0S1	Gene names	Atf7
Domain Architecture	No domain graphic available
Description	Cyclic AMP-dependent transcription factor ATF-7 (Activating transcription factor 7) (Transcription factor ATF-A).

ATF7_HUMAN
NC score	0.032856 (rank : 89)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	333	Shared Neighborhood Hits	7
SwissProt Accessions	P17544, Q13814	Gene names	ATF7, ATFA
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-7 (Activating transcription factor 7) (Transcription factor ATF-A).

CDSN_MOUSE
NC score	0.024133 (rank : 90)	θ value	1.06291 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	131	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

PODXL_HUMAN
NC score	0.024110 (rank : 91)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	191	Shared Neighborhood Hits	8
SwissProt Accessions	O00592	Gene names	PODXL, PCLP, PCLP1
Domain Architecture
Description	Podocalyxin-like protein 1 precursor.

OGFR_HUMAN
NC score	0.023051 (rank : 92)	θ value	0.0961366 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	1582	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

R3HD2_MOUSE
NC score	0.022758 (rank : 93)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	397	Shared Neighborhood Hits	12
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

EP300_HUMAN
NC score	0.020886 (rank : 94)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	821	Shared Neighborhood Hits	22
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

BSN_MOUSE
NC score	0.020134 (rank : 95)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	2057	Shared Neighborhood Hits	26
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

FHOD1_HUMAN
NC score	0.019206 (rank : 96)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	184	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FHOD1_MOUSE
NC score	0.018729 (rank : 97)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

ALEX_HUMAN
NC score	0.015726 (rank : 98)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	361	Shared Neighborhood Hits	9
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

PLCD1_MOUSE
NC score	0.015555 (rank : 99)	θ value	1.81305 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

EPIPL_HUMAN
NC score	0.014150 (rank : 100)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

CASL_HUMAN
NC score	0.013827 (rank : 101)	θ value	2.36792 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

DDX24_HUMAN
NC score	0.012311 (rank : 102)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZR7	Gene names	DDX24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

CTND2_HUMAN
NC score	0.008786 (rank : 103)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

CCNT1_MOUSE
NC score	0.008565 (rank : 104)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QWV9, Q9Z0U7	Gene names	Ccnt1
Domain Architecture
Description	Cyclin-T1 (CycT1) (Cyclin-T).

CTND2_MOUSE
NC score	0.007971 (rank : 105)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	227	Shared Neighborhood Hits	6
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

PDE8A_MOUSE
NC score	0.006986 (rank : 106)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE8A_HUMAN
NC score	0.006031 (rank : 107)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

TAB2_MOUSE
NC score	0.004967 (rank : 108)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	4
SwissProt Accessions	Q99K90, Q3UGP1, Q8BTP4, Q8CHD3, Q99KP4	Gene names	Map3k7ip2, Kiaa0733, Tab2
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (TAK1-binding protein 2) (TAB2).

PLEC1_HUMAN
NC score	0.004750 (rank : 109)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	1326	Shared Neighborhood Hits	10
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

NEDD1_MOUSE
NC score	0.003201 (rank : 110)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	2
SwissProt Accessions	P33215, Q6NXV3, Q8BN12, Q8BN86, Q8BQL9, Q9CWK2	Gene names	Nedd1, Nedd-1
Domain Architecture	No domain graphic available
Description	Protein NEDD1 (Neural precursor cell expressed developmentally down- regulated protein 1).

RHES_MOUSE
NC score	0.003081 (rank : 111)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	P63032, Q9WVD3	Gene names	Rasd2
Domain Architecture	No domain graphic available
Description	GTP-binding protein Rhes (Ras homolog enriched in striatum).

RHES_HUMAN
NC score	0.002345 (rank : 112)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q96D21, O95520, Q5THY8	Gene names	RASD2, TEM2
Domain Architecture
Description	GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2).

CO9A2_HUMAN
NC score	0.001206 (rank : 113)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	261	Shared Neighborhood Hits	5
SwissProt Accessions	Q14055	Gene names	COL9A2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

APOA_HUMAN
NC score	-0.000885 (rank : 114)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	221	Shared Neighborhood Hits	3
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

ZN485_HUMAN
NC score	-0.001385 (rank : 115)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	744	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NCK3, Q96CL0	Gene names	ZNF485
Domain Architecture	No domain graphic available
Description	Zinc finger protein 485.

EPHA1_HUMAN
NC score	-0.001445 (rank : 116)	θ value	1.38821 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	997	Shared Neighborhood Hits	6
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

UFO_HUMAN
NC score	-0.002788 (rank : 117)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	981	Shared Neighborhood Hits	5
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ZN228_HUMAN
NC score	-0.003024 (rank : 118)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	775	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJU3, Q9HCA7	Gene names	ZNF228
Domain Architecture
Description	Zinc finger protein 228.

GAK_HUMAN
NC score	-0.003192 (rank : 119)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	1028	Shared Neighborhood Hits	6
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

ZNF7_HUMAN
NC score	-0.003581 (rank : 120)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	770	Shared Neighborhood Hits	5
SwissProt Accessions	P17097, P17015	Gene names	ZNF7, KOX4
Domain Architecture
Description	Zinc finger protein 7 (Zinc finger protein KOX4) (Zinc finger protein HF.16).