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Network neighborhood for query Sequence : NPAS1_HUMAN

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NPAS1_HUMAN
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPAS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	0 (rank : 2)	NC score	0.994444 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	63	Shared Neighborhood Hits	36
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_MOUSE
θ value	4.03687e-117 (rank : 3)	NC score	0.968659 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	3.41741e-116 (rank : 4)	NC score	0.970903 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

SIM2_MOUSE
θ value	5.51964e-74 (rank : 5)	NC score	0.951467 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	33
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM2_HUMAN
θ value	2.09745e-73 (rank : 6)	NC score	0.953012 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM1_HUMAN
θ value	3.57772e-73 (rank : 7)	NC score	0.945933 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	32
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	1.04096e-72 (rank : 8)	NC score	0.945290 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_HUMAN
θ value	6.56568e-51 (rank : 9)	NC score	0.906437 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	118	Shared Neighborhood Hits	34
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	1.91031e-50 (rank : 10)	NC score	0.908878 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

EPAS1_HUMAN
θ value	2.3352e-48 (rank : 11)	NC score	0.900224 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	6.7944e-48 (rank : 12)	NC score	0.899572 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

BMAL1_HUMAN
θ value	3.17815e-21 (rank : 13)	NC score	0.743139 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	7.0802e-21 (rank : 14)	NC score	0.740541 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	121	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

AHR_HUMAN
θ value	2.27762e-19 (rank : 15)	NC score	0.805712 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	2.7842e-17 (rank : 16)	NC score	0.802056 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	55	Shared Neighborhood Hits	32
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CLOCK_MOUSE
θ value	3.76295e-14 (rank : 17)	NC score	0.701195 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS4_HUMAN
θ value	6.41864e-14 (rank : 18)	NC score	0.670872 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	8.38298e-14 (rank : 19)	NC score	0.657755 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

CLOCK_HUMAN
θ value	1.86753e-13 (rank : 20)	NC score	0.702971 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

ARNT2_HUMAN
θ value	2.69671e-12 (rank : 21)	NC score	0.682830 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	4.59992e-12 (rank : 22)	NC score	0.681275 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NCOA1_MOUSE
θ value	1.33837e-11 (rank : 23)	NC score	0.603229 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	196	Shared Neighborhood Hits	37
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	1.74796e-11 (rank : 24)	NC score	0.600679 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

ARNT_HUMAN
θ value	1.9326e-10 (rank : 25)	NC score	0.669309 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	109	Shared Neighborhood Hits	34
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.9326e-10 (rank : 26)	NC score	0.659219 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	213	Shared Neighborhood Hits	37
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_MOUSE
θ value	2.79066e-09 (rank : 27)	NC score	0.670979 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	132	Shared Neighborhood Hits	39
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NCOA2_HUMAN
θ value	1.38499e-08 (rank : 28)	NC score	0.535100 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	1.38499e-08 (rank : 29)	NC score	0.534650 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NPAS2_HUMAN
θ value	2.36244e-08 (rank : 30)	NC score	0.661296 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NCOA3_HUMAN
θ value	2.61198e-07 (rank : 31)	NC score	0.527169 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	1.09739e-05 (rank : 32)	NC score	0.492031 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	203	Shared Neighborhood Hits	36
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

CTDP1_MOUSE
θ value	0.0736092 (rank : 33)	NC score	0.036815 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	146	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SPEG_MOUSE
θ value	0.163984 (rank : 34)	NC score	0.003484 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	1959	Shared Neighborhood Hits	21
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PCLO_MOUSE
θ value	0.365318 (rank : 35)	NC score	0.022490 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	2275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRRT3_HUMAN
θ value	0.365318 (rank : 36)	NC score	0.021876 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CASC3_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.026304 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

BTBD7_MOUSE
θ value	0.813845 (rank : 38)	NC score	0.018369 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

OGFR_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.023031 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	1582	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BRD8_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.024196 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	422	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

MUC1_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.009962 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	975	Shared Neighborhood Hits	21
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

CGRE1_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.027112 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

PI5PA_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.020612 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	749	Shared Neighborhood Hits	21
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

SELPL_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.033969 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	588	Shared Neighborhood Hits	21
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

BRD8_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.021031 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	292	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

MLL3_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.017242 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	1644	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NFH_MOUSE
θ value	2.36792 (rank : 47)	NC score	0.009887 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	2247	Shared Neighborhood Hits	31
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TCF8_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.002404 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	1067	Shared Neighborhood Hits	12
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

CN032_HUMAN
θ value	3.0926 (rank : 49)	NC score	0.023952 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

DAXX_MOUSE
θ value	3.0926 (rank : 50)	NC score	0.014604 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	173	Shared Neighborhood Hits	6
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

MTSS1_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.019530 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	592	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

CX039_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.014282 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2D0, Q3U3R2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein CXorf39 homolog.

MAGE1_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.011885 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	1389	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MTSS1_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.020588 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	504	Shared Neighborhood Hits	15
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

NEST_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.003949 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	1305	Shared Neighborhood Hits	18
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

RGS3_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.014191 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	1621	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

BCOR_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.006354 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	609	Shared Neighborhood Hits	9
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

PGCB_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.004169 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	478	Shared Neighborhood Hits	12
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

FOXN1_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.004064 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	377	Shared Neighborhood Hits	10
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

K1802_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.014520 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	1378	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

OGFR_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.013943 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	584	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

RGS3_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.009207 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	1375	Shared Neighborhood Hits	27
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TFEB_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.062053 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.061330 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

ZC11A_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.009208 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

AKAP1_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.006961 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

ASPP1_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.013261 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	1244	Shared Neighborhood Hits	29
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCOR_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.005304 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	521	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CLCB_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.006104 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	P09497, Q6FHW1	Gene names	CLTB
Domain Architecture
Description	Clathrin light chain B (Lcb).

ECM1_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.008024 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	182	Shared Neighborhood Hits	5
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

HPS4_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.007980 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

IL4RA_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.008520 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

PDZD2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.004232 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	772	Shared Neighborhood Hits	10
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

SLIK1_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.000049 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	333	Shared Neighborhood Hits	5
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.

SMAD4_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.003852 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

TCF15_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.009785 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

TULP1_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.006115 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	O00294, O43536	Gene names	TULP1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

HES5_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.052870 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.074448 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.077762 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.083841 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.081527 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MITF_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.061277 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.062227 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	15
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.052925 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.053426 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PER1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.165747 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.163256 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.166965 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.150724 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	325	Shared Neighborhood Hits	22
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.160438 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER3_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.180859 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

TCFL5_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.060381 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.059525 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.052605 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.052580 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.051585 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	155	Shared Neighborhood Hits	10
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

Hits sorted by NC score

NPAS1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	77
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
NC score	0.994444 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	77	Target Neighborhood Hits	63	Shared Neighborhood Hits	36
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
NC score	0.970903 (rank : 3)	θ value	3.41741e-116 (rank : 4)
Query Neighborhood Hits	77	Target Neighborhood Hits	81	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.968659 (rank : 4)	θ value	4.03687e-117 (rank : 3)
Query Neighborhood Hits	77	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

SIM2_HUMAN
NC score	0.953012 (rank : 5)	θ value	2.09745e-73 (rank : 6)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.951467 (rank : 6)	θ value	5.51964e-74 (rank : 5)
Query Neighborhood Hits	77	Target Neighborhood Hits	75	Shared Neighborhood Hits	33
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.945933 (rank : 7)	θ value	3.57772e-73 (rank : 7)
Query Neighborhood Hits	77	Target Neighborhood Hits	62	Shared Neighborhood Hits	32
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.945290 (rank : 8)	θ value	1.04096e-72 (rank : 8)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_MOUSE
NC score	0.908878 (rank : 9)	θ value	1.91031e-50 (rank : 10)
Query Neighborhood Hits	77	Target Neighborhood Hits	90	Shared Neighborhood Hits	33
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.906437 (rank : 10)	θ value	6.56568e-51 (rank : 9)
Query Neighborhood Hits	77	Target Neighborhood Hits	118	Shared Neighborhood Hits	34
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_HUMAN
NC score	0.900224 (rank : 11)	θ value	2.3352e-48 (rank : 11)
Query Neighborhood Hits	77	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.899572 (rank : 12)	θ value	6.7944e-48 (rank : 12)
Query Neighborhood Hits	77	Target Neighborhood Hits	94	Shared Neighborhood Hits	34
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_HUMAN
NC score	0.805712 (rank : 13)	θ value	2.27762e-19 (rank : 15)
Query Neighborhood Hits	77	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.802056 (rank : 14)	θ value	2.7842e-17 (rank : 16)
Query Neighborhood Hits	77	Target Neighborhood Hits	55	Shared Neighborhood Hits	32
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
NC score	0.743139 (rank : 15)	θ value	3.17815e-21 (rank : 13)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.740541 (rank : 16)	θ value	7.0802e-21 (rank : 14)
Query Neighborhood Hits	77	Target Neighborhood Hits	121	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
NC score	0.702971 (rank : 17)	θ value	1.86753e-13 (rank : 20)
Query Neighborhood Hits	77	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.701195 (rank : 18)	θ value	3.76295e-14 (rank : 17)
Query Neighborhood Hits	77	Target Neighborhood Hits	148	Shared Neighborhood Hits	35
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT2_HUMAN
NC score	0.682830 (rank : 19)	θ value	2.69671e-12 (rank : 21)
Query Neighborhood Hits	77	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.681275 (rank : 20)	θ value	4.59992e-12 (rank : 22)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NPAS2_MOUSE
NC score	0.670979 (rank : 21)	θ value	2.79066e-09 (rank : 27)
Query Neighborhood Hits	77	Target Neighborhood Hits	132	Shared Neighborhood Hits	39
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS4_HUMAN
NC score	0.670872 (rank : 22)	θ value	6.41864e-14 (rank : 18)
Query Neighborhood Hits	77	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

ARNT_HUMAN
NC score	0.669309 (rank : 23)	θ value	1.9326e-10 (rank : 25)
Query Neighborhood Hits	77	Target Neighborhood Hits	109	Shared Neighborhood Hits	34
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_HUMAN
NC score	0.661296 (rank : 24)	θ value	2.36244e-08 (rank : 30)
Query Neighborhood Hits	77	Target Neighborhood Hits	150	Shared Neighborhood Hits	35
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_MOUSE
NC score	0.659219 (rank : 25)	θ value	1.9326e-10 (rank : 26)
Query Neighborhood Hits	77	Target Neighborhood Hits	213	Shared Neighborhood Hits	37
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_MOUSE
NC score	0.657755 (rank : 26)	θ value	8.38298e-14 (rank : 19)
Query Neighborhood Hits	77	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.603229 (rank : 27)	θ value	1.33837e-11 (rank : 23)
Query Neighborhood Hits	77	Target Neighborhood Hits	196	Shared Neighborhood Hits	37
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.600679 (rank : 28)	θ value	1.74796e-11 (rank : 24)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	37
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
NC score	0.535100 (rank : 29)	θ value	1.38499e-08 (rank : 28)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
NC score	0.534650 (rank : 30)	θ value	1.38499e-08 (rank : 29)
Query Neighborhood Hits	77	Target Neighborhood Hits	281	Shared Neighborhood Hits	38
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
NC score	0.527169 (rank : 31)	θ value	2.61198e-07 (rank : 31)
Query Neighborhood Hits	77	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.492031 (rank : 32)	θ value	1.09739e-05 (rank : 32)
Query Neighborhood Hits	77	Target Neighborhood Hits	203	Shared Neighborhood Hits	36
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.180859 (rank : 33)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	77	Target Neighborhood Hits	85	Shared Neighborhood Hits	22
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.166965 (rank : 34)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	77	Target Neighborhood Hits	170	Shared Neighborhood Hits	25
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.165747 (rank : 35)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	77	Target Neighborhood Hits	215	Shared Neighborhood Hits	30
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.163256 (rank : 36)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	77	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.160438 (rank : 37)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	77	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.150724 (rank : 38)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	77	Target Neighborhood Hits	325	Shared Neighborhood Hits	22
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.083841 (rank : 39)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	77	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.081527 (rank : 40)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	77	Target Neighborhood Hits	80	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.077762 (rank : 41)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	77	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.074448 (rank : 42)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	77	Target Neighborhood Hits	82	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MITF_MOUSE
NC score	0.062227 (rank : 43)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	77	Target Neighborhood Hits	115	Shared Neighborhood Hits	15
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
NC score	0.062053 (rank : 44)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	77	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.061330 (rank : 45)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	77	Target Neighborhood Hits	119	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MITF_HUMAN
NC score	0.061277 (rank : 46)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	77	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TCFL5_HUMAN
NC score	0.060381 (rank : 47)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
NC score	0.059525 (rank : 48)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	77	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MLX_MOUSE
NC score	0.053426 (rank : 49)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	77	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.052925 (rank : 50)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	77	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

HES5_MOUSE
NC score	0.052870 (rank : 51)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	77	Target Neighborhood Hits	38	Shared Neighborhood Hits	12
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

USF1_HUMAN
NC score	0.052605 (rank : 52)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	77	Target Neighborhood Hits	70	Shared Neighborhood Hits	10
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.052580 (rank : 53)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	77	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.051585 (rank : 54)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	77	Target Neighborhood Hits	155	Shared Neighborhood Hits	10
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

CTDP1_MOUSE
NC score	0.036815 (rank : 55)	θ value	0.0736092 (rank : 33)
Query Neighborhood Hits	77	Target Neighborhood Hits	146	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SELPL_MOUSE
NC score	0.033969 (rank : 56)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	77	Target Neighborhood Hits	588	Shared Neighborhood Hits	21
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

CGRE1_HUMAN
NC score	0.027112 (rank : 57)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	77	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

CASC3_MOUSE
NC score	0.026304 (rank : 58)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	77	Target Neighborhood Hits	333	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

BRD8_MOUSE
NC score	0.024196 (rank : 59)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	77	Target Neighborhood Hits	422	Shared Neighborhood Hits	15
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

CN032_HUMAN
NC score	0.023952 (rank : 60)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	77	Target Neighborhood Hits	267	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

OGFR_HUMAN
NC score	0.023031 (rank : 61)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	77	Target Neighborhood Hits	1582	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PCLO_MOUSE
NC score	0.022490 (rank : 62)	θ value	0.365318 (rank : 35)
Query Neighborhood Hits	77	Target Neighborhood Hits	2275	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRRT3_HUMAN
NC score	0.021876 (rank : 63)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	77	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

BRD8_HUMAN
NC score	0.021031 (rank : 64)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	77	Target Neighborhood Hits	292	Shared Neighborhood Hits	8
SwissProt Accessions	Q9H0E9, O43178, Q15355, Q59GN0, Q969M9	Gene names	BRD8, SMAP
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8 (p120) (Skeletal muscle abundant protein) (Thyroid hormone receptor coactivating protein 120kDa) (TrCP120).

PI5PA_HUMAN
NC score	0.020612 (rank : 65)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	77	Target Neighborhood Hits	749	Shared Neighborhood Hits	21
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

MTSS1_HUMAN
NC score	0.020588 (rank : 66)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	77	Target Neighborhood Hits	504	Shared Neighborhood Hits	15
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MTSS1_MOUSE
NC score	0.019530 (rank : 67)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	77	Target Neighborhood Hits	592	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

BTBD7_MOUSE
NC score	0.018369 (rank : 68)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	77	Target Neighborhood Hits	228	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

MLL3_HUMAN
NC score	0.017242 (rank : 69)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	77	Target Neighborhood Hits	1644	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DAXX_MOUSE
NC score	0.014604 (rank : 70)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	77	Target Neighborhood Hits	173	Shared Neighborhood Hits	6
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

K1802_HUMAN
NC score	0.014520 (rank : 71)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	77	Target Neighborhood Hits	1378	Shared Neighborhood Hits	26
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CX039_MOUSE
NC score	0.014282 (rank : 72)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	77	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K2D0, Q3U3R2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein CXorf39 homolog.

RGS3_MOUSE
NC score	0.014191 (rank : 73)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	77	Target Neighborhood Hits	1621	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

OGFR_MOUSE
NC score	0.013943 (rank : 74)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	77	Target Neighborhood Hits	584	Shared Neighborhood Hits	16
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

ASPP1_MOUSE
NC score	0.013261 (rank : 75)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	77	Target Neighborhood Hits	1244	Shared Neighborhood Hits	29
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

MAGE1_HUMAN
NC score	0.011885 (rank : 76)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	77	Target Neighborhood Hits	1389	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MUC1_HUMAN
NC score	0.009962 (rank : 77)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	77	Target Neighborhood Hits	975	Shared Neighborhood Hits	21
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NFH_MOUSE
NC score	0.009887 (rank : 78)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	77	Target Neighborhood Hits	2247	Shared Neighborhood Hits	31
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TCF15_HUMAN
NC score	0.009785 (rank : 79)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	77	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

ZC11A_MOUSE
NC score	0.009208 (rank : 80)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	77	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NZF1, Q6NXW9, Q6PDR6, Q80TU7, Q8C5L5, Q99JN6	Gene names	Zc3h11a, Kiaa0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

RGS3_HUMAN
NC score	0.009207 (rank : 81)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	77	Target Neighborhood Hits	1375	Shared Neighborhood Hits	27
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

IL4RA_MOUSE
NC score	0.008520 (rank : 82)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	77	Target Neighborhood Hits	194	Shared Neighborhood Hits	7
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

ECM1_HUMAN
NC score	0.008024 (rank : 83)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	77	Target Neighborhood Hits	182	Shared Neighborhood Hits	5
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

HPS4_HUMAN
NC score	0.007980 (rank : 84)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	77	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

AKAP1_MOUSE
NC score	0.006961 (rank : 85)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	77	Target Neighborhood Hits	198	Shared Neighborhood Hits	7
SwissProt Accessions	O08715, O08714, P97488	Gene names	Akap1, Akap
Domain Architecture
Description	A kinase anchor protein 1, mitochondrial precursor (Protein kinase A- anchoring protein 1) (PRKA1) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Spermatid A-kinase anchor protein) (S-AKAP).

BCOR_HUMAN
NC score	0.006354 (rank : 86)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	77	Target Neighborhood Hits	609	Shared Neighborhood Hits	9
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

TULP1_HUMAN
NC score	0.006115 (rank : 87)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	77	Target Neighborhood Hits	144	Shared Neighborhood Hits	7
SwissProt Accessions	O00294, O43536	Gene names	TULP1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

CLCB_HUMAN
NC score	0.006104 (rank : 88)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	77	Target Neighborhood Hits	137	Shared Neighborhood Hits	4
SwissProt Accessions	P09497, Q6FHW1	Gene names	CLTB
Domain Architecture
Description	Clathrin light chain B (Lcb).

BCOR_MOUSE
NC score	0.005304 (rank : 89)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	77	Target Neighborhood Hits	521	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

PDZD2_HUMAN
NC score	0.004232 (rank : 90)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	77	Target Neighborhood Hits	772	Shared Neighborhood Hits	10
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PGCB_HUMAN
NC score	0.004169 (rank : 91)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	77	Target Neighborhood Hits	478	Shared Neighborhood Hits	12
SwissProt Accessions	Q96GW7, Q8TBB9, Q9HBK1, Q9HBK4	Gene names	BCAN, BEHAB, CSPG7
Domain Architecture	No domain graphic available
Description	Brevican core protein precursor (Brain-enriched hyaluronan-binding protein) (Protein BEHAB).

FOXN1_HUMAN
NC score	0.004064 (rank : 92)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	77	Target Neighborhood Hits	377	Shared Neighborhood Hits	10
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

NEST_HUMAN
NC score	0.003949 (rank : 93)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	77	Target Neighborhood Hits	1305	Shared Neighborhood Hits	18
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

SMAD4_HUMAN
NC score	0.003852 (rank : 94)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	77	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SPEG_MOUSE
NC score	0.003484 (rank : 95)	θ value	0.163984 (rank : 34)
Query Neighborhood Hits	77	Target Neighborhood Hits	1959	Shared Neighborhood Hits	21
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TCF8_MOUSE
NC score	0.002404 (rank : 96)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	77	Target Neighborhood Hits	1067	Shared Neighborhood Hits	12
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

SLIK1_MOUSE
NC score	0.000049 (rank : 97)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	77	Target Neighborhood Hits	333	Shared Neighborhood Hits	5
SwissProt Accessions	Q810C1, Q9CXL0	Gene names	Slitrk1, Sltk1
Domain Architecture
Description	SLIT and NTRK-like protein 1 precursor.