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Network neighborhood for query Sequence : MLX_HUMAN

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MLX_HUMAN
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MLX_HUMAN
θ value	3.16172e-154 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	2.42647e-146 (rank : 2)	NC score	0.995677 (rank : 2)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	92
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

WBS14_MOUSE
θ value	5.07402e-19 (rank : 3)	NC score	0.561233 (rank : 3)
Query Neighborhood Hits	95	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

WBS14_HUMAN
θ value	4.29542e-18 (rank : 4)	NC score	0.527060 (rank : 4)
Query Neighborhood Hits	95	Target Neighborhood Hits	273	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HEY1_HUMAN
θ value	2.21117e-06 (rank : 5)	NC score	0.357690 (rank : 11)
Query Neighborhood Hits	95	Target Neighborhood Hits	82	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MAX_MOUSE
θ value	6.43352e-06 (rank : 6)	NC score	0.466353 (rank : 5)
Query Neighborhood Hits	95	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

HEY1_MOUSE
θ value	8.40245e-06 (rank : 7)	NC score	0.354748 (rank : 12)
Query Neighborhood Hits	95	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

USF1_HUMAN
θ value	1.09739e-05 (rank : 8)	NC score	0.422540 (rank : 8)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	1.09739e-05 (rank : 9)	NC score	0.422919 (rank : 7)
Query Neighborhood Hits	95	Target Neighborhood Hits	71	Shared Neighborhood Hits	39
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MAX_HUMAN
θ value	2.44474e-05 (rank : 10)	NC score	0.456274 (rank : 6)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

USF2_HUMAN
θ value	0.000121331 (rank : 11)	NC score	0.409565 (rank : 10)
Query Neighborhood Hits	95	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	0.000121331 (rank : 12)	NC score	0.413324 (rank : 9)
Query Neighborhood Hits	95	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

TFAP4_HUMAN
θ value	0.000158464 (rank : 13)	NC score	0.347068 (rank : 13)
Query Neighborhood Hits	95	Target Neighborhood Hits	289	Shared Neighborhood Hits	42
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

SRBP1_MOUSE
θ value	0.00020696 (rank : 14)	NC score	0.280985 (rank : 21)
Query Neighborhood Hits	95	Target Neighborhood Hits	384	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BMAL1_HUMAN
θ value	0.000602161 (rank : 15)	NC score	0.220625 (rank : 28)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

SRBP1_HUMAN
θ value	0.000786445 (rank : 16)	NC score	0.285776 (rank : 19)
Query Neighborhood Hits	95	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BMAL1_MOUSE
θ value	0.00102713 (rank : 17)	NC score	0.219350 (rank : 29)
Query Neighborhood Hits	95	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

HEY2_HUMAN
θ value	0.00134147 (rank : 18)	NC score	0.316461 (rank : 14)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	0.00134147 (rank : 19)	NC score	0.315946 (rank : 15)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

CLOCK_MOUSE
θ value	0.00228821 (rank : 20)	NC score	0.195161 (rank : 34)
Query Neighborhood Hits	95	Target Neighborhood Hits	148	Shared Neighborhood Hits	37
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
θ value	0.00390308 (rank : 21)	NC score	0.192155 (rank : 36)
Query Neighborhood Hits	95	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MYCS_MOUSE
θ value	0.00390308 (rank : 22)	NC score	0.284466 (rank : 20)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_HUMAN
θ value	0.00390308 (rank : 23)	NC score	0.287072 (rank : 18)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	0.00509761 (rank : 24)	NC score	0.287996 (rank : 17)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TFE3_HUMAN
θ value	0.00665767 (rank : 25)	NC score	0.293632 (rank : 16)
Query Neighborhood Hits	95	Target Neighborhood Hits	190	Shared Neighborhood Hits	48
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TRIPB_HUMAN
θ value	0.0431538 (rank : 26)	NC score	0.044791 (rank : 120)
Query Neighborhood Hits	95	Target Neighborhood Hits	1587	Shared Neighborhood Hits	31
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

MYO10_HUMAN
θ value	0.0736092 (rank : 27)	NC score	0.036158 (rank : 124)
Query Neighborhood Hits	95	Target Neighborhood Hits	920	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYCL1_MOUSE
θ value	0.0961366 (rank : 28)	NC score	0.233032 (rank : 26)
Query Neighborhood Hits	95	Target Neighborhood Hits	123	Shared Neighborhood Hits	37
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCN_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.253691 (rank : 23)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	34
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_HUMAN
θ value	0.125558 (rank : 30)	NC score	0.268579 (rank : 22)
Query Neighborhood Hits	95	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

TCFL5_HUMAN
θ value	0.163984 (rank : 31)	NC score	0.191355 (rank : 37)
Query Neighborhood Hits	95	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

ITF2_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.055884 (rank : 107)
Query Neighborhood Hits	95	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

MYCL1_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.230778 (rank : 27)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

BHLH3_HUMAN
θ value	0.279714 (rank : 34)	NC score	0.203244 (rank : 31)
Query Neighborhood Hits	95	Target Neighborhood Hits	106	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	0.279714 (rank : 35)	NC score	0.202722 (rank : 32)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

MITF_HUMAN
θ value	0.279714 (rank : 36)	NC score	0.248498 (rank : 24)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

FIGLA_HUMAN
θ value	0.365318 (rank : 37)	NC score	0.145003 (rank : 47)
Query Neighborhood Hits	95	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HEN1_MOUSE
θ value	0.365318 (rank : 38)	NC score	0.115668 (rank : 56)
Query Neighborhood Hits	95	Target Neighborhood Hits	86	Shared Neighborhood Hits	20
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
θ value	0.365318 (rank : 39)	NC score	0.123550 (rank : 53)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

MYH8_MOUSE
θ value	0.365318 (rank : 40)	NC score	0.027853 (rank : 137)
Query Neighborhood Hits	95	Target Neighborhood Hits	1600	Shared Neighborhood Hits	32
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

NPAS2_HUMAN
θ value	0.365318 (rank : 41)	NC score	0.160216 (rank : 43)
Query Neighborhood Hits	95	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.365318 (rank : 42)	NC score	0.159474 (rank : 44)
Query Neighborhood Hits	95	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

HEN2_MOUSE
θ value	0.47712 (rank : 43)	NC score	0.121550 (rank : 54)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

PHAR2_HUMAN
θ value	0.47712 (rank : 44)	NC score	0.057117 (rank : 104)
Query Neighborhood Hits	95	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

BHLH2_HUMAN
θ value	0.62314 (rank : 45)	NC score	0.183370 (rank : 38)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	34
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

MITF_MOUSE
θ value	0.62314 (rank : 46)	NC score	0.242450 (rank : 25)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

FIGLA_MOUSE
θ value	0.813845 (rank : 47)	NC score	0.143895 (rank : 48)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

BHLH2_MOUSE
θ value	1.06291 (rank : 48)	NC score	0.174464 (rank : 39)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

ERBB3_HUMAN
θ value	1.06291 (rank : 49)	NC score	0.011055 (rank : 153)
Query Neighborhood Hits	95	Target Neighborhood Hits	918	Shared Neighborhood Hits	6
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

TAL1_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.105550 (rank : 57)
Query Neighborhood Hits	95	Target Neighborhood Hits	112	Shared Neighborhood Hits	27
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.104314 (rank : 58)
Query Neighborhood Hits	95	Target Neighborhood Hits	110	Shared Neighborhood Hits	27
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TULP1_MOUSE
θ value	1.06291 (rank : 52)	NC score	0.033407 (rank : 128)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z273	Gene names	Tulp1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

CENPE_HUMAN
θ value	1.38821 (rank : 53)	NC score	0.024858 (rank : 142)
Query Neighborhood Hits	95	Target Neighborhood Hits	2060	Shared Neighborhood Hits	35
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

EZRI_MOUSE
θ value	1.38821 (rank : 54)	NC score	0.029607 (rank : 133)
Query Neighborhood Hits	95	Target Neighborhood Hits	693	Shared Neighborhood Hits	18
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

RBBP6_MOUSE
θ value	1.38821 (rank : 55)	NC score	0.034189 (rank : 127)
Query Neighborhood Hits	95	Target Neighborhood Hits	1014	Shared Neighborhood Hits	16
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

NCOA1_HUMAN
θ value	1.81305 (rank : 56)	NC score	0.093402 (rank : 61)
Query Neighborhood Hits	95	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	1.81305 (rank : 57)	NC score	0.093152 (rank : 62)
Query Neighborhood Hits	95	Target Neighborhood Hits	196	Shared Neighborhood Hits	24
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

PLXD1_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.018846 (rank : 149)
Query Neighborhood Hits	95	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

BRD2_HUMAN
θ value	2.36792 (rank : 59)	NC score	0.024930 (rank : 141)
Query Neighborhood Hits	95	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

ID1_HUMAN
θ value	2.36792 (rank : 60)	NC score	0.086330 (rank : 69)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID1_MOUSE
θ value	2.36792 (rank : 61)	NC score	0.089374 (rank : 63)
Query Neighborhood Hits	95	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

RB6I2_HUMAN
θ value	2.36792 (rank : 62)	NC score	0.028975 (rank : 135)
Query Neighborhood Hits	95	Target Neighborhood Hits	1584	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
θ value	2.36792 (rank : 63)	NC score	0.028616 (rank : 136)
Query Neighborhood Hits	95	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

ATF2_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.027491 (rank : 138)
Query Neighborhood Hits	95	Target Neighborhood Hits	402	Shared Neighborhood Hits	10
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

CLK1_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.004436 (rank : 156)
Query Neighborhood Hits	95	Target Neighborhood Hits	756	Shared Neighborhood Hits	6
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

EZRI_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.026835 (rank : 139)
Query Neighborhood Hits	95	Target Neighborhood Hits	663	Shared Neighborhood Hits	18
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

ERBB3_MOUSE
θ value	4.03905 (rank : 67)	NC score	0.008350 (rank : 155)
Query Neighborhood Hits	95	Target Neighborhood Hits	898	Shared Neighborhood Hits	7
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

HOME2_MOUSE
θ value	4.03905 (rank : 68)	NC score	0.031577 (rank : 132)
Query Neighborhood Hits	95	Target Neighborhood Hits	882	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

MYF5_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.054681 (rank : 110)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

NGN1_MOUSE
θ value	4.03905 (rank : 70)	NC score	0.043326 (rank : 121)
Query Neighborhood Hits	95	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

CTRO_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.011115 (rank : 152)
Query Neighborhood Hits	95	Target Neighborhood Hits	2092	Shared Neighborhood Hits	29
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.010825 (rank : 154)
Query Neighborhood Hits	95	Target Neighborhood Hits	2344	Shared Neighborhood Hits	29
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

FOSL1_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.036484 (rank : 123)
Query Neighborhood Hits	95	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P15407	Gene names	FOSL1, FRA1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

FOSL1_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.037222 (rank : 122)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	P48755, O35285	Gene names	Fosl1, Fra1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

GOGA1_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.023938 (rank : 144)
Query Neighborhood Hits	95	Target Neighborhood Hits	994	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

HEN1_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.086481 (rank : 68)
Query Neighborhood Hits	95	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HOME2_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.033244 (rank : 130)
Query Neighborhood Hits	95	Target Neighborhood Hits	532	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

MYF5_MOUSE
θ value	5.27518 (rank : 78)	NC score	0.054392 (rank : 112)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

TRAK2_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.034592 (rank : 126)
Query Neighborhood Hits	95	Target Neighborhood Hits	476	Shared Neighborhood Hits	19
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

XLR_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.035291 (rank : 125)
Query Neighborhood Hits	95	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	P05531	Gene names	Xlr
Domain Architecture
Description	X-linked lymphocyte-regulated protein PM1.

ARNT2_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.155168 (rank : 46)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.155944 (rank : 45)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	6.88961 (rank : 83)	NC score	0.162662 (rank : 41)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.160892 (rank : 42)
Query Neighborhood Hits	95	Target Neighborhood Hits	213	Shared Neighborhood Hits	42
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ATF2_MOUSE
θ value	6.88961 (rank : 85)	NC score	0.023420 (rank : 145)
Query Neighborhood Hits	95	Target Neighborhood Hits	397	Shared Neighborhood Hits	7
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

CDC37_MOUSE
θ value	6.88961 (rank : 86)	NC score	0.032057 (rank : 131)
Query Neighborhood Hits	95	Target Neighborhood Hits	359	Shared Neighborhood Hits	19
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CENPF_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.022838 (rank : 147)
Query Neighborhood Hits	95	Target Neighborhood Hits	1932	Shared Neighborhood Hits	35
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CV019_HUMAN
θ value	6.88961 (rank : 88)	NC score	0.033369 (rank : 129)
Query Neighborhood Hits	95	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q13769, O60839, Q9UPZ5	Gene names	C22orf19, KIAA0983
Domain Architecture	No domain graphic available
Description	Protein C22orf19 (NF2/meningioma region protein pK1.3) (Placental protein 39.2).

INCE_HUMAN
θ value	6.88961 (rank : 89)	NC score	0.023378 (rank : 146)
Query Neighborhood Hits	95	Target Neighborhood Hits	978	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

MDN1_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.029241 (rank : 134)
Query Neighborhood Hits	95	Target Neighborhood Hits	662	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MYH13_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.021701 (rank : 148)
Query Neighborhood Hits	95	Target Neighborhood Hits	1504	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PACE1_MOUSE
θ value	6.88961 (rank : 92)	NC score	0.013931 (rank : 150)
Query Neighborhood Hits	95	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

CCD11_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.024767 (rank : 143)
Query Neighborhood Hits	95	Target Neighborhood Hits	498	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD27_MOUSE
θ value	8.99809 (rank : 94)	NC score	0.025576 (rank : 140)
Query Neighborhood Hits	95	Target Neighborhood Hits	461	Shared Neighborhood Hits	15
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

SPTN2_HUMAN
θ value	8.99809 (rank : 95)	NC score	0.011384 (rank : 151)
Query Neighborhood Hits	95	Target Neighborhood Hits	535	Shared Neighborhood Hits	19
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

AHR_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.067215 (rank : 83)
Query Neighborhood Hits	95	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.065958 (rank : 85)
Query Neighborhood Hits	95	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

ASCL1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.050721 (rank : 118)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	22
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

BHLH8_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.077450 (rank : 76)
Query Neighborhood Hits	95	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.078414 (rank : 74)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

EPAS1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.067531 (rank : 82)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.066027 (rank : 84)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HAND1_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.063090 (rank : 92)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND1_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.060059 (rank : 97)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

HAND2_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.069915 (rank : 80)
Query Neighborhood Hits	95	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.069915 (rank : 81)
Query Neighborhood Hits	95	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

HES1_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.125961 (rank : 51)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.126264 (rank : 50)
Query Neighborhood Hits	95	Target Neighborhood Hits	78	Shared Neighborhood Hits	24
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES2_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.084460 (rank : 70)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.089226 (rank : 64)
Query Neighborhood Hits	95	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.081453 (rank : 73)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES4_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.133155 (rank : 49)
Query Neighborhood Hits	95	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES5_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.123943 (rank : 52)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.088625 (rank : 65)
Query Neighborhood Hits	95	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.087348 (rank : 67)
Query Neighborhood Hits	95	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.075966 (rank : 77)
Query Neighborhood Hits	95	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.075215 (rank : 78)
Query Neighborhood Hits	95	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HIF1A_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.065863 (rank : 86)
Query Neighborhood Hits	95	Target Neighborhood Hits	118	Shared Neighborhood Hits	12
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.065299 (rank : 87)
Query Neighborhood Hits	95	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

LYL1_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.055588 (rank : 108)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

LYL1_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.053554 (rank : 114)
Query Neighborhood Hits	95	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

MAD1_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.062415 (rank : 93)
Query Neighborhood Hits	95	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD3_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.077650 (rank : 75)
Query Neighborhood Hits	95	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAD3_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.071306 (rank : 79)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD4_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.083128 (rank : 72)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD4_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.054001 (rank : 113)
Query Neighborhood Hits	95	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MNT_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.100387 (rank : 59)
Query Neighborhood Hits	95	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.097276 (rank : 60)
Query Neighborhood Hits	95	Target Neighborhood Hits	432	Shared Neighborhood Hits	36
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MXI1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.083630 (rank : 71)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	26
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.088264 (rank : 66)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCB_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.117011 (rank : 55)
Query Neighborhood Hits	95	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

MYCL2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.165798 (rank : 40)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

NCOA2_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.056961 (rank : 106)
Query Neighborhood Hits	95	Target Neighborhood Hits	281	Shared Neighborhood Hits	12
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.057472 (rank : 103)
Query Neighborhood Hits	95	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.060993 (rank : 94)
Query Neighborhood Hits	95	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.054518 (rank : 111)
Query Neighborhood Hits	95	Target Neighborhood Hits	203	Shared Neighborhood Hits	13
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.052925 (rank : 115)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.055104 (rank : 109)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.058510 (rank : 102)
Query Neighborhood Hits	95	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.059499 (rank : 100)
Query Neighborhood Hits	95	Target Neighborhood Hits	103	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS4_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.052680 (rank : 116)
Query Neighborhood Hits	95	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

PER2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.050693 (rank : 119)
Query Neighborhood Hits	95	Target Neighborhood Hits	325	Shared Neighborhood Hits	14
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PTF1A_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.058681 (rank : 101)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.057038 (rank : 105)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

SIM1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.063610 (rank : 91)
Query Neighborhood Hits	95	Target Neighborhood Hits	62	Shared Neighborhood Hits	16
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.063885 (rank : 90)
Query Neighborhood Hits	95	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.064821 (rank : 88)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.064261 (rank : 89)
Query Neighborhood Hits	95	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SRBP2_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.211956 (rank : 30)
Query Neighborhood Hits	95	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TAL2_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.051142 (rank : 117)
Query Neighborhood Hits	95	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

TFEB_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.194593 (rank : 35)
Query Neighborhood Hits	95	Target Neighborhood Hits	111	Shared Neighborhood Hits	41
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.198261 (rank : 33)
Query Neighborhood Hits	95	Target Neighborhood Hits	119	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TWST1_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.060588 (rank : 95)
Query Neighborhood Hits	95	Target Neighborhood Hits	93	Shared Neighborhood Hits	24
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.060515 (rank : 96)
Query Neighborhood Hits	95	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TWST2_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.059742 (rank : 99)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.059834 (rank : 98)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

Hits sorted by NC score

MLX_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.16172e-154 (rank : 1)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	95
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.995677 (rank : 2)	θ value	2.42647e-146 (rank : 2)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	92
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

WBS14_MOUSE
NC score	0.561233 (rank : 3)	θ value	5.07402e-19 (rank : 3)
Query Neighborhood Hits	95	Target Neighborhood Hits	171	Shared Neighborhood Hits	16
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

WBS14_HUMAN
NC score	0.527060 (rank : 4)	θ value	4.29542e-18 (rank : 4)
Query Neighborhood Hits	95	Target Neighborhood Hits	273	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

MAX_MOUSE
NC score	0.466353 (rank : 5)	θ value	6.43352e-06 (rank : 6)
Query Neighborhood Hits	95	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.456274 (rank : 6)	θ value	2.44474e-05 (rank : 10)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

USF1_MOUSE
NC score	0.422919 (rank : 7)	θ value	1.09739e-05 (rank : 9)
Query Neighborhood Hits	95	Target Neighborhood Hits	71	Shared Neighborhood Hits	39
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.422540 (rank : 8)	θ value	1.09739e-05 (rank : 8)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	39
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
NC score	0.413324 (rank : 9)	θ value	0.000121331 (rank : 12)
Query Neighborhood Hits	95	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.409565 (rank : 10)	θ value	0.000121331 (rank : 11)
Query Neighborhood Hits	95	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

HEY1_HUMAN
NC score	0.357690 (rank : 11)	θ value	2.21117e-06 (rank : 5)
Query Neighborhood Hits	95	Target Neighborhood Hits	82	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
NC score	0.354748 (rank : 12)	θ value	8.40245e-06 (rank : 7)
Query Neighborhood Hits	95	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

TFAP4_HUMAN
NC score	0.347068 (rank : 13)	θ value	0.000158464 (rank : 13)
Query Neighborhood Hits	95	Target Neighborhood Hits	289	Shared Neighborhood Hits	42
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

HEY2_HUMAN
NC score	0.316461 (rank : 14)	θ value	0.00134147 (rank : 18)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.315946 (rank : 15)	θ value	0.00134147 (rank : 19)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

TFE3_HUMAN
NC score	0.293632 (rank : 16)	θ value	0.00665767 (rank : 25)
Query Neighborhood Hits	95	Target Neighborhood Hits	190	Shared Neighborhood Hits	48
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MYC_MOUSE
NC score	0.287996 (rank : 17)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_HUMAN
NC score	0.287072 (rank : 18)	θ value	0.00390308 (rank : 23)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SRBP1_HUMAN
NC score	0.285776 (rank : 19)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	95	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCS_MOUSE
NC score	0.284466 (rank : 20)	θ value	0.00390308 (rank : 22)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

SRBP1_MOUSE
NC score	0.280985 (rank : 21)	θ value	0.00020696 (rank : 14)
Query Neighborhood Hits	95	Target Neighborhood Hits	384	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCN_HUMAN
NC score	0.268579 (rank : 22)	θ value	0.125558 (rank : 30)
Query Neighborhood Hits	95	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
NC score	0.253691 (rank : 23)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	95	Target Neighborhood Hits	125	Shared Neighborhood Hits	34
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MITF_HUMAN
NC score	0.248498 (rank : 24)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.242450 (rank : 25)	θ value	0.62314 (rank : 46)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MYCL1_MOUSE
NC score	0.233032 (rank : 26)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	95	Target Neighborhood Hits	123	Shared Neighborhood Hits	37
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_HUMAN
NC score	0.230778 (rank : 27)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

BMAL1_HUMAN
NC score	0.220625 (rank : 28)	θ value	0.000602161 (rank : 15)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.219350 (rank : 29)	θ value	0.00102713 (rank : 17)
Query Neighborhood Hits	95	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

SRBP2_HUMAN
NC score	0.211956 (rank : 30)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	95	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

BHLH3_HUMAN
NC score	0.203244 (rank : 31)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	95	Target Neighborhood Hits	106	Shared Neighborhood Hits	32
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.202722 (rank : 32)	θ value	0.279714 (rank : 35)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

TFEB_MOUSE
NC score	0.198261 (rank : 33)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	95	Target Neighborhood Hits	119	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

CLOCK_MOUSE
NC score	0.195161 (rank : 34)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	95	Target Neighborhood Hits	148	Shared Neighborhood Hits	37
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

TFEB_HUMAN
NC score	0.194593 (rank : 35)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	95	Target Neighborhood Hits	111	Shared Neighborhood Hits	41
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

CLOCK_HUMAN
NC score	0.192155 (rank : 36)	θ value	0.00390308 (rank : 21)
Query Neighborhood Hits	95	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

TCFL5_HUMAN
NC score	0.191355 (rank : 37)	θ value	0.163984 (rank : 31)
Query Neighborhood Hits	95	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

BHLH2_HUMAN
NC score	0.183370 (rank : 38)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	34
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.174464 (rank : 39)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	95	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

MYCL2_HUMAN
NC score	0.165798 (rank : 40)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

ARNT_HUMAN
NC score	0.162662 (rank : 41)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.160892 (rank : 42)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	95	Target Neighborhood Hits	213	Shared Neighborhood Hits	42
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_HUMAN
NC score	0.160216 (rank : 43)	θ value	0.365318 (rank : 41)
Query Neighborhood Hits	95	Target Neighborhood Hits	150	Shared Neighborhood Hits	30
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.159474 (rank : 44)	θ value	0.365318 (rank : 42)
Query Neighborhood Hits	95	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

ARNT2_MOUSE
NC score	0.155944 (rank : 45)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	95	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.155168 (rank : 46)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

FIGLA_HUMAN
NC score	0.145003 (rank : 47)	θ value	0.365318 (rank : 37)
Query Neighborhood Hits	95	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_MOUSE
NC score	0.143895 (rank : 48)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES4_HUMAN
NC score	0.133155 (rank : 49)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	95	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_MOUSE
NC score	0.126264 (rank : 50)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	95	Target Neighborhood Hits	78	Shared Neighborhood Hits	24
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.125961 (rank : 51)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	24
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES5_MOUSE
NC score	0.123943 (rank : 52)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEN2_HUMAN
NC score	0.123550 (rank : 53)	θ value	0.365318 (rank : 39)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
NC score	0.121550 (rank : 54)	θ value	0.47712 (rank : 43)
Query Neighborhood Hits	95	Target Neighborhood Hits	83	Shared Neighborhood Hits	20
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

MYCB_MOUSE
NC score	0.117011 (rank : 55)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	95	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

HEN1_MOUSE
NC score	0.115668 (rank : 56)	θ value	0.365318 (rank : 38)
Query Neighborhood Hits	95	Target Neighborhood Hits	86	Shared Neighborhood Hits	20
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

TAL1_HUMAN
NC score	0.105550 (rank : 57)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	95	Target Neighborhood Hits	112	Shared Neighborhood Hits	27
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
NC score	0.104314 (rank : 58)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	95	Target Neighborhood Hits	110	Shared Neighborhood Hits	27
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

MNT_HUMAN
NC score	0.100387 (rank : 59)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	95	Target Neighborhood Hits	496	Shared Neighborhood Hits	37
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
NC score	0.097276 (rank : 60)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	95	Target Neighborhood Hits	432	Shared Neighborhood Hits	36
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCOA1_HUMAN
NC score	0.093402 (rank : 61)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	95	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
NC score	0.093152 (rank : 62)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	95	Target Neighborhood Hits	196	Shared Neighborhood Hits	24
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

ID1_MOUSE
NC score	0.089374 (rank : 63)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	95	Target Neighborhood Hits	64	Shared Neighborhood Hits	20
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

HES2_MOUSE
NC score	0.089226 (rank : 64)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	95	Target Neighborhood Hits	36	Shared Neighborhood Hits	12
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_HUMAN
NC score	0.088625 (rank : 65)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	95	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

MXI1_MOUSE
NC score	0.088264 (rank : 66)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	95	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

HES6_MOUSE
NC score	0.087348 (rank : 67)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	95	Target Neighborhood Hits	49	Shared Neighborhood Hits	12
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HEN1_HUMAN
NC score	0.086481 (rank : 68)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	95	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

ID1_HUMAN
NC score	0.086330 (rank : 69)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

HES2_HUMAN
NC score	0.084460 (rank : 70)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MXI1_HUMAN
NC score	0.083630 (rank : 71)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	26
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_HUMAN
NC score	0.083128 (rank : 72)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HES3_MOUSE
NC score	0.081453 (rank : 73)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	95	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH8_MOUSE
NC score	0.078414 (rank : 74)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

MAD3_HUMAN
NC score	0.077650 (rank : 75)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	95	Target Neighborhood Hits	92	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

BHLH8_HUMAN
NC score	0.077450 (rank : 76)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	95	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

HES7_HUMAN
NC score	0.075966 (rank : 77)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	95	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.075215 (rank : 78)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	95	Target Neighborhood Hits	72	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD3_MOUSE
NC score	0.071306 (rank : 79)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

HAND2_HUMAN
NC score	0.069915 (rank : 80)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	95	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.069915 (rank : 81)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	95	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

EPAS1_HUMAN
NC score	0.067531 (rank : 82)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

AHR_HUMAN
NC score	0.067215 (rank : 83)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	95	Target Neighborhood Hits	47	Shared Neighborhood Hits	14
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

EPAS1_MOUSE
NC score	0.066027 (rank : 84)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	12
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_MOUSE
NC score	0.065958 (rank : 85)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	95	Target Neighborhood Hits	55	Shared Neighborhood Hits	12
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

HIF1A_HUMAN
NC score	0.065863 (rank : 86)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	95	Target Neighborhood Hits	118	Shared Neighborhood Hits	12
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.065299 (rank : 87)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	95	Target Neighborhood Hits	90	Shared Neighborhood Hits	12
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM2_HUMAN
NC score	0.064821 (rank : 88)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	95	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.064261 (rank : 89)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	95	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_MOUSE
NC score	0.063885 (rank : 90)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	95	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.063610 (rank : 91)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	95	Target Neighborhood Hits	62	Shared Neighborhood Hits	16
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

HAND1_HUMAN
NC score	0.063090 (rank : 92)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

MAD1_MOUSE
NC score	0.062415 (rank : 93)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	95	Target Neighborhood Hits	75	Shared Neighborhood Hits	26
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

NCOA3_HUMAN
NC score	0.060993 (rank : 94)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	95	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

TWST1_HUMAN
NC score	0.060588 (rank : 95)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	95	Target Neighborhood Hits	93	Shared Neighborhood Hits	24
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
NC score	0.060515 (rank : 96)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	95	Target Neighborhood Hits	101	Shared Neighborhood Hits	24
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

HAND1_MOUSE
NC score	0.060059 (rank : 97)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

TWST2_MOUSE
NC score	0.059834 (rank : 98)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.059742 (rank : 99)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	95	Target Neighborhood Hits	107	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

NPAS3_MOUSE
NC score	0.059499 (rank : 100)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	95	Target Neighborhood Hits	103	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PTF1A_HUMAN
NC score	0.058681 (rank : 101)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	95	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

NPAS3_HUMAN
NC score	0.058510 (rank : 102)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	95	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NCOA2_MOUSE
NC score	0.057472 (rank : 103)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	95	Target Neighborhood Hits	281	Shared Neighborhood Hits	13
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

PHAR2_HUMAN
NC score	0.057117 (rank : 104)	θ value	0.47712 (rank : 44)
Query Neighborhood Hits	95	Target Neighborhood Hits	208	Shared Neighborhood Hits	3
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

PTF1A_MOUSE
NC score	0.057038 (rank : 105)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	95	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

NCOA2_HUMAN
NC score	0.056961 (rank : 106)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	95	Target Neighborhood Hits	281	Shared Neighborhood Hits	12
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

ITF2_MOUSE
NC score	0.055884 (rank : 107)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	95	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

LYL1_HUMAN
NC score	0.055588 (rank : 108)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

NPAS1_MOUSE
NC score	0.055104 (rank : 109)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	95	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

MYF5_HUMAN
NC score	0.054681 (rank : 110)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	95	Target Neighborhood Hits	80	Shared Neighborhood Hits	19
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

NCOA3_MOUSE
NC score	0.054518 (rank : 111)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	95	Target Neighborhood Hits	203	Shared Neighborhood Hits	13
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

MYF5_MOUSE
NC score	0.054392 (rank : 112)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	19
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MAD4_MOUSE
NC score	0.054001 (rank : 113)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	95	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

LYL1_MOUSE
NC score	0.053554 (rank : 114)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	95	Target Neighborhood Hits	102	Shared Neighborhood Hits	20
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

NPAS1_HUMAN
NC score	0.052925 (rank : 115)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	95	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS4_HUMAN
NC score	0.052680 (rank : 116)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	95	Target Neighborhood Hits	214	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

TAL2_MOUSE
NC score	0.051142 (rank : 117)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	95	Target Neighborhood Hits	79	Shared Neighborhood Hits	19
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

ASCL1_HUMAN
NC score	0.050721 (rank : 118)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	95	Target Neighborhood Hits	94	Shared Neighborhood Hits	22
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

PER2_MOUSE
NC score	0.050693 (rank : 119)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	95	Target Neighborhood Hits	325	Shared Neighborhood Hits	14
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

TRIPB_HUMAN
NC score	0.044791 (rank : 120)	θ value	0.0431538 (rank : 26)
Query Neighborhood Hits	95	Target Neighborhood Hits	1587	Shared Neighborhood Hits	31
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

NGN1_MOUSE
NC score	0.043326 (rank : 121)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	95	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

FOSL1_MOUSE
NC score	0.037222 (rank : 122)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	95	Target Neighborhood Hits	113	Shared Neighborhood Hits	9
SwissProt Accessions	P48755, O35285	Gene names	Fosl1, Fra1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

FOSL1_HUMAN
NC score	0.036484 (rank : 123)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	95	Target Neighborhood Hits	112	Shared Neighborhood Hits	8
SwissProt Accessions	P15407	Gene names	FOSL1, FRA1
Domain Architecture
Description	Fos-related antigen 1 (FRA-1).

MYO10_HUMAN
NC score	0.036158 (rank : 124)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	95	Target Neighborhood Hits	920	Shared Neighborhood Hits	23
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

XLR_MOUSE
NC score	0.035291 (rank : 125)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	95	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	P05531	Gene names	Xlr
Domain Architecture
Description	X-linked lymphocyte-regulated protein PM1.

TRAK2_HUMAN
NC score	0.034592 (rank : 126)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	95	Target Neighborhood Hits	476	Shared Neighborhood Hits	19
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

RBBP6_MOUSE
NC score	0.034189 (rank : 127)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	95	Target Neighborhood Hits	1014	Shared Neighborhood Hits	16
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

TULP1_MOUSE
NC score	0.033407 (rank : 128)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	95	Target Neighborhood Hits	146	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z273	Gene names	Tulp1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

CV019_HUMAN
NC score	0.033369 (rank : 129)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	95	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q13769, O60839, Q9UPZ5	Gene names	C22orf19, KIAA0983
Domain Architecture	No domain graphic available
Description	Protein C22orf19 (NF2/meningioma region protein pK1.3) (Placental protein 39.2).

HOME2_HUMAN
NC score	0.033244 (rank : 130)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	95	Target Neighborhood Hits	532	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

CDC37_MOUSE
NC score	0.032057 (rank : 131)	θ value	6.88961 (rank : 86)
Query Neighborhood Hits	95	Target Neighborhood Hits	359	Shared Neighborhood Hits	19
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

HOME2_MOUSE
NC score	0.031577 (rank : 132)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	95	Target Neighborhood Hits	882	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

EZRI_MOUSE
NC score	0.029607 (rank : 133)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	95	Target Neighborhood Hits	693	Shared Neighborhood Hits	18
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

MDN1_HUMAN
NC score	0.029241 (rank : 134)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	95	Target Neighborhood Hits	662	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

RB6I2_HUMAN
NC score	0.028975 (rank : 135)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	95	Target Neighborhood Hits	1584	Shared Neighborhood Hits	28
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RB6I2_MOUSE
NC score	0.028616 (rank : 136)	θ value	2.36792 (rank : 63)
Query Neighborhood Hits	95	Target Neighborhood Hits	1433	Shared Neighborhood Hits	29
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

MYH8_MOUSE
NC score	0.027853 (rank : 137)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	95	Target Neighborhood Hits	1600	Shared Neighborhood Hits	32
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

ATF2_HUMAN
NC score	0.027491 (rank : 138)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	95	Target Neighborhood Hits	402	Shared Neighborhood Hits	10
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

EZRI_HUMAN
NC score	0.026835 (rank : 139)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	95	Target Neighborhood Hits	663	Shared Neighborhood Hits	18
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

CCD27_MOUSE
NC score	0.025576 (rank : 140)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	95	Target Neighborhood Hits	461	Shared Neighborhood Hits	15
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

BRD2_HUMAN
NC score	0.024930 (rank : 141)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	95	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	P25440, O00699, O00700, Q15310, Q5STC9, Q969U4	Gene names	BRD2, KIAA9001, RING3
Domain Architecture
Description	Bromodomain-containing protein 2 (Protein RING3) (O27.1.1).

CENPE_HUMAN
NC score	0.024858 (rank : 142)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	95	Target Neighborhood Hits	2060	Shared Neighborhood Hits	35
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CCD11_MOUSE
NC score	0.024767 (rank : 143)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	95	Target Neighborhood Hits	498	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

GOGA1_MOUSE
NC score	0.023938 (rank : 144)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	95	Target Neighborhood Hits	994	Shared Neighborhood Hits	28
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

ATF2_MOUSE
NC score	0.023420 (rank : 145)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	95	Target Neighborhood Hits	397	Shared Neighborhood Hits	7
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

INCE_HUMAN
NC score	0.023378 (rank : 146)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	95	Target Neighborhood Hits	978	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

CENPF_HUMAN
NC score	0.022838 (rank : 147)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	95	Target Neighborhood Hits	1932	Shared Neighborhood Hits	35
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MYH13_HUMAN
NC score	0.021701 (rank : 148)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	95	Target Neighborhood Hits	1504	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PLXD1_HUMAN
NC score	0.018846 (rank : 149)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	95	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4D7, Q6PJS9, Q8IZJ2, Q9BTQ2	Gene names	PLXND1, KIAA0620
Domain Architecture	No domain graphic available
Description	Plexin-D1 precursor.

PACE1_MOUSE
NC score	0.013931 (rank : 150)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	95	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

SPTN2_HUMAN
NC score	0.011384 (rank : 151)	θ value	8.99809 (rank : 95)
Query Neighborhood Hits	95	Target Neighborhood Hits	535	Shared Neighborhood Hits	19
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

CTRO_HUMAN
NC score	0.011115 (rank : 152)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	95	Target Neighborhood Hits	2092	Shared Neighborhood Hits	29
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ERBB3_HUMAN
NC score	0.011055 (rank : 153)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	95	Target Neighborhood Hits	918	Shared Neighborhood Hits	6
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

CTRO_MOUSE
NC score	0.010825 (rank : 154)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	95	Target Neighborhood Hits	2344	Shared Neighborhood Hits	29
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ERBB3_MOUSE
NC score	0.008350 (rank : 155)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	95	Target Neighborhood Hits	898	Shared Neighborhood Hits	7
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

CLK1_HUMAN
NC score	0.004436 (rank : 156)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	95	Target Neighborhood Hits	756	Shared Neighborhood Hits	6
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).