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Network neighborhood for query Sequence : HES7_HUMAN

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HES7_HUMAN
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES7_MOUSE
θ value	2.08775e-89 (rank : 1)	NC score	0.981917 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
θ value	5.33382e-77 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES4_HUMAN
θ value	6.00763e-12 (rank : 3)	NC score	0.750303 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_MOUSE
θ value	1.74796e-11 (rank : 4)	NC score	0.766543 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES5_MOUSE
θ value	3.29651e-10 (rank : 5)	NC score	0.772983 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES1_HUMAN
θ value	9.59137e-10 (rank : 6)	NC score	0.704143 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	31
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	9.59137e-10 (rank : 7)	NC score	0.703848 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES2_HUMAN
θ value	1.63604e-09 (rank : 8)	NC score	0.748039 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_MOUSE
θ value	5.81887e-07 (rank : 9)	NC score	0.640890 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HEY1_HUMAN
θ value	7.59969e-07 (rank : 10)	NC score	0.595518 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES6_HUMAN
θ value	2.21117e-06 (rank : 11)	NC score	0.641857 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HEY1_MOUSE
θ value	4.92598e-06 (rank : 12)	NC score	0.592650 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES3_MOUSE
θ value	8.40245e-06 (rank : 13)	NC score	0.636604 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HEY2_HUMAN
θ value	1.09739e-05 (rank : 14)	NC score	0.586043 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	1.09739e-05 (rank : 15)	NC score	0.585908 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

BHLH2_HUMAN
θ value	0.00228821 (rank : 16)	NC score	0.416387 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	0.0330416 (rank : 17)	NC score	0.394978 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	27
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

SPR1B_MOUSE
θ value	0.0431538 (rank : 18)	NC score	0.072331 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

CEL_HUMAN
θ value	0.0736092 (rank : 19)	NC score	0.036501 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	896	Shared Neighborhood Hits	17
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

BHLH3_MOUSE
θ value	0.21417 (rank : 20)	NC score	0.370824 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
θ value	0.279714 (rank : 21)	NC score	0.372051 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

NPAS2_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.096405 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.279714 (rank : 23)	NC score	0.096850 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	132	Shared Neighborhood Hits	27
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

MTG8R_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.057165 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

MTG8R_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.056152 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	124	Shared Neighborhood Hits	4
SwissProt Accessions	O70374	Gene names	Cbfa2t2, Cbfa2t2h, Mtgr1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1).

NCOA1_HUMAN
θ value	0.62314 (rank : 26)	NC score	0.093977 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	0.62314 (rank : 27)	NC score	0.096433 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

SON_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.037252 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	1568	Shared Neighborhood Hits	30
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPR1A_MOUSE
θ value	1.06291 (rank : 29)	NC score	0.050006 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ZIMP7_MOUSE
θ value	1.06291 (rank : 30)	NC score	0.030986 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	566	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

LPP_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.025838 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

PCLO_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.031908 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	2275	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

ULK1_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.002867 (rank : 90)
Query Neighborhood Hits	72	Target Neighborhood Hits	1214	Shared Neighborhood Hits	12
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ZN385_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.047349 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ERBB2_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.003358 (rank : 89)
Query Neighborhood Hits	72	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

LIMD1_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.031741 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	201	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

MLL3_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.021298 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	1644	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ATS13_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.010260 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

BMAL1_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.115533 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.116966 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CF155_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.055600 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

TGIF_MOUSE
θ value	3.0926 (rank : 42)	NC score	0.016353 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	P70284, Q921F9, Q99JS3	Gene names	Tgif
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

MITF_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.110038 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.106353 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

NFAC1_HUMAN
θ value	4.03905 (rank : 45)	NC score	0.017847 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	312	Shared Neighborhood Hits	10
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

NRX2A_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.017670 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.025318 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	481	Shared Neighborhood Hits	11
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

TM55A_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.032773 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4L2, Q68CU2	Gene names	TMEM55A
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55A (EC 3.1.3.-) (Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase II).

TM55A_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.032861 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZX7	Gene names	Tmem55a
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55A (EC 3.1.3.-) (Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase II).

TTC28_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.018786 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	271	Shared Neighborhood Hits	6
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ETV5_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.011754 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	328	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

NEO1_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.007187 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	523	Shared Neighborhood Hits	4
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

OGFR_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.019965 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	1582	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHLB1_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.013447 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	1038	Shared Neighborhood Hits	13
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SRBP1_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.077181 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	384	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TAF6L_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.020414 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R2K4, Q8C5T2	Gene names	Taf6l, Paf65a
Domain Architecture
Description	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65 alpha) (PAF65- alpha).

AHR_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.054063 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CD2_HUMAN
θ value	6.88961 (rank : 58)	NC score	0.017847 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	504	Shared Neighborhood Hits	9
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CU069_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.029885 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58556	Gene names	C21orf69
Domain Architecture	No domain graphic available
Description	Protein C21orf69.

GCH1_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.023209 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

NACAM_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.022424 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	1866	Shared Neighborhood Hits	30
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NEO1_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.006726 (rank : 88)
Query Neighborhood Hits	72	Target Neighborhood Hits	530	Shared Neighborhood Hits	4
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

RNF8_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.007563 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	618	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

TARSH_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.026551 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	768	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

CAC1G_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.008890 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	587	Shared Neighborhood Hits	11
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CLOCK_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.083351 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CRSP2_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.022330 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	380	Shared Neighborhood Hits	10
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

ERCC2_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.015976 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

MAP1A_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.012528 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NCOA3_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.051778 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

TFEB_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.085237 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.086174 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	119	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

ARNT2_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.061423 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.062514 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.061988 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.062167 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	213	Shared Neighborhood Hits	28
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.077631 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MLX_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.075966 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	95	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.077041 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PRP2_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.059783 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	26
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PRR13_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.056829 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

SMR1_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.053493 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SPR2D_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.050216 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P22532, Q5T523, Q96RM3	Gene names	SPRR2D
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II).

SRBP1_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.080851 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	31
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.075300 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	133	Shared Neighborhood Hits	23
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFE3_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.093915 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	190	Shared Neighborhood Hits	26
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.071250 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	21
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.071194 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.064187 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.068204 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	22
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

HES7_HUMAN
NC score	0.999962 (rank : 1)	θ value	5.33382e-77 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.981917 (rank : 2)	θ value	2.08775e-89 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES5_MOUSE
NC score	0.772983 (rank : 3)	θ value	3.29651e-10 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	26
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES2_MOUSE
NC score	0.766543 (rank : 4)	θ value	1.74796e-11 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES4_HUMAN
NC score	0.750303 (rank : 5)	θ value	6.00763e-12 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_HUMAN
NC score	0.748039 (rank : 6)	θ value	1.63604e-09 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES1_HUMAN
NC score	0.704143 (rank : 7)	θ value	9.59137e-10 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	31
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.703848 (rank : 8)	θ value	9.59137e-10 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES6_HUMAN
NC score	0.641857 (rank : 9)	θ value	2.21117e-06 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.640890 (rank : 10)	θ value	5.81887e-07 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES3_MOUSE
NC score	0.636604 (rank : 11)	θ value	8.40245e-06 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HEY1_HUMAN
NC score	0.595518 (rank : 12)	θ value	7.59969e-07 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
NC score	0.592650 (rank : 13)	θ value	4.92598e-06 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
NC score	0.586043 (rank : 14)	θ value	1.09739e-05 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.585908 (rank : 15)	θ value	1.09739e-05 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

BHLH2_HUMAN
NC score	0.416387 (rank : 16)	θ value	0.00228821 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.394978 (rank : 17)	θ value	0.0330416 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	27
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
NC score	0.372051 (rank : 18)	θ value	0.279714 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.370824 (rank : 19)	θ value	0.21417 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BMAL1_MOUSE
NC score	0.116966 (rank : 20)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.115533 (rank : 21)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MITF_HUMAN
NC score	0.110038 (rank : 22)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.106353 (rank : 23)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

NPAS2_MOUSE
NC score	0.096850 (rank : 24)	θ value	0.279714 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	132	Shared Neighborhood Hits	27
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NCOA1_MOUSE
NC score	0.096433 (rank : 25)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NPAS2_HUMAN
NC score	0.096405 (rank : 26)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	150	Shared Neighborhood Hits	25
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NCOA1_HUMAN
NC score	0.093977 (rank : 27)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	198	Shared Neighborhood Hits	22
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

TFE3_HUMAN
NC score	0.093915 (rank : 28)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	190	Shared Neighborhood Hits	26
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_MOUSE
NC score	0.086174 (rank : 29)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	119	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.085237 (rank : 30)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

CLOCK_HUMAN
NC score	0.083351 (rank : 31)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	127	Shared Neighborhood Hits	26
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

SRBP1_HUMAN
NC score	0.080851 (rank : 32)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	31
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

CLOCK_MOUSE
NC score	0.077631 (rank : 33)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	26
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

SRBP1_MOUSE
NC score	0.077181 (rank : 34)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	384	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MLX_MOUSE
NC score	0.077041 (rank : 35)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.075966 (rank : 36)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	95	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP2_HUMAN
NC score	0.075300 (rank : 37)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	133	Shared Neighborhood Hits	23
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SPR1B_MOUSE
NC score	0.072331 (rank : 38)	θ value	0.0431538 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	395	Shared Neighborhood Hits	12
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

USF1_HUMAN
NC score	0.071250 (rank : 39)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	21
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.071194 (rank : 40)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	72	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
NC score	0.068204 (rank : 41)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	22
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.064187 (rank : 42)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	72	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

ARNT2_MOUSE
NC score	0.062514 (rank : 43)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_MOUSE
NC score	0.062167 (rank : 44)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	213	Shared Neighborhood Hits	28
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_HUMAN
NC score	0.061988 (rank : 45)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
NC score	0.061423 (rank : 46)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

PRP2_MOUSE
NC score	0.059783 (rank : 47)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	347	Shared Neighborhood Hits	26
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

MTG8R_HUMAN
NC score	0.057165 (rank : 48)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

PRR13_HUMAN
NC score	0.056829 (rank : 49)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

MTG8R_MOUSE
NC score	0.056152 (rank : 50)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	124	Shared Neighborhood Hits	4
SwissProt Accessions	O70374	Gene names	Cbfa2t2, Cbfa2t2h, Mtgr1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1).

CF155_HUMAN
NC score	0.055600 (rank : 51)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H8W2, Q5TG13	Gene names	C6orf155
Domain Architecture	No domain graphic available
Description	Protein C6orf155.

AHR_HUMAN
NC score	0.054063 (rank : 52)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

SMR1_MOUSE
NC score	0.053493 (rank : 53)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

NCOA3_HUMAN
NC score	0.051778 (rank : 54)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

SPR2D_HUMAN
NC score	0.050216 (rank : 55)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	P22532, Q5T523, Q96RM3	Gene names	SPRR2D
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D (SPR-2D) (Small proline-rich protein II) (SPR-II).

SPR1A_MOUSE
NC score	0.050006 (rank : 56)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	343	Shared Neighborhood Hits	8
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ZN385_HUMAN
NC score	0.047349 (rank : 57)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

SON_HUMAN
NC score	0.037252 (rank : 58)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	1568	Shared Neighborhood Hits	30
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CEL_HUMAN
NC score	0.036501 (rank : 59)	θ value	0.0736092 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	896	Shared Neighborhood Hits	17
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

TM55A_MOUSE
NC score	0.032861 (rank : 60)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CZX7	Gene names	Tmem55a
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55A (EC 3.1.3.-) (Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase II).

TM55A_HUMAN
NC score	0.032773 (rank : 61)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4L2, Q68CU2	Gene names	TMEM55A
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55A (EC 3.1.3.-) (Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase II).

PCLO_MOUSE
NC score	0.031908 (rank : 62)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	2275	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

LIMD1_HUMAN
NC score	0.031741 (rank : 63)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	201	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

ZIMP7_MOUSE
NC score	0.030986 (rank : 64)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	566	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CU069_HUMAN
NC score	0.029885 (rank : 65)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P58556	Gene names	C21orf69
Domain Architecture	No domain graphic available
Description	Protein C21orf69.

TARSH_HUMAN
NC score	0.026551 (rank : 66)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	768	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

LPP_HUMAN
NC score	0.025838 (rank : 67)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NRX2B_HUMAN
NC score	0.025318 (rank : 68)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	481	Shared Neighborhood Hits	11
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

GCH1_HUMAN
NC score	0.023209 (rank : 69)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

NACAM_MOUSE
NC score	0.022424 (rank : 70)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	1866	Shared Neighborhood Hits	30
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

CRSP2_HUMAN
NC score	0.022330 (rank : 71)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	380	Shared Neighborhood Hits	10
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

MLL3_HUMAN
NC score	0.021298 (rank : 72)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	1644	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

TAF6L_MOUSE
NC score	0.020414 (rank : 73)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	146	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R2K4, Q8C5T2	Gene names	Taf6l, Paf65a
Domain Architecture
Description	TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (PCAF-associated factor 65 alpha) (PAF65- alpha).

OGFR_HUMAN
NC score	0.019965 (rank : 74)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	1582	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TTC28_HUMAN
NC score	0.018786 (rank : 75)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	271	Shared Neighborhood Hits	6
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

NFAC1_HUMAN
NC score	0.017847 (rank : 76)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	312	Shared Neighborhood Hits	10
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

CD2_HUMAN
NC score	0.017847 (rank : 77)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	504	Shared Neighborhood Hits	9
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

NRX2A_HUMAN
NC score	0.017670 (rank : 78)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	11
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

TGIF_MOUSE
NC score	0.016353 (rank : 79)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	P70284, Q921F9, Q99JS3	Gene names	Tgif
Domain Architecture
Description	5'-TG-3'-interacting factor (Homeobox protein TGIF).

ERCC2_MOUSE
NC score	0.015976 (rank : 80)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

PHLB1_HUMAN
NC score	0.013447 (rank : 81)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	1038	Shared Neighborhood Hits	13
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MAP1A_HUMAN
NC score	0.012528 (rank : 82)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	1626	Shared Neighborhood Hits	21
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ETV5_MOUSE
NC score	0.011754 (rank : 83)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	328	Shared Neighborhood Hits	10
SwissProt Accessions	Q9CXC9, Q3TG49, Q8C0F3, Q9JHB1	Gene names	Etv5
Domain Architecture	No domain graphic available
Description	ETS translocation variant 5.

ATS13_HUMAN
NC score	0.010260 (rank : 84)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

CAC1G_HUMAN
NC score	0.008890 (rank : 85)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	587	Shared Neighborhood Hits	11
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

RNF8_MOUSE
NC score	0.007563 (rank : 86)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	618	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

NEO1_MOUSE
NC score	0.007187 (rank : 87)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	523	Shared Neighborhood Hits	4
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NEO1_HUMAN
NC score	0.006726 (rank : 88)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	530	Shared Neighborhood Hits	4
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

ERBB2_HUMAN
NC score	0.003358 (rank : 89)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	1073	Shared Neighborhood Hits	7
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ULK1_MOUSE
NC score	0.002867 (rank : 90)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	1214	Shared Neighborhood Hits	12
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).