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Network neighborhood for query Sequence : HES2_MOUSE

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HES2_MOUSE
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES2_MOUSE
θ value	3.35642e-63 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
θ value	3.72821e-46 (rank : 2)	NC score	0.986247 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES4_HUMAN
θ value	4.43474e-23 (rank : 3)	NC score	0.925658 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
θ value	1.86321e-21 (rank : 4)	NC score	0.892437 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	1.86321e-21 (rank : 5)	NC score	0.892278 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES7_HUMAN
θ value	1.74796e-11 (rank : 6)	NC score	0.766543 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES6_MOUSE
θ value	3.89403e-11 (rank : 7)	NC score	0.788506 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES6_HUMAN
θ value	6.64225e-11 (rank : 8)	NC score	0.794941 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES7_MOUSE
θ value	6.64225e-11 (rank : 9)	NC score	0.759426 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HEY2_MOUSE
θ value	5.62301e-10 (rank : 10)	NC score	0.724373 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
θ value	2.13673e-09 (rank : 11)	NC score	0.721280 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HES5_MOUSE
θ value	6.21693e-09 (rank : 12)	NC score	0.831350 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_HUMAN
θ value	6.21693e-09 (rank : 13)	NC score	0.711457 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	8.11959e-09 (rank : 14)	NC score	0.713370 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

BHLH2_HUMAN
θ value	4.92598e-06 (rank : 15)	NC score	0.538535 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	7.1131e-05 (rank : 16)	NC score	0.513980 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES3_MOUSE
θ value	0.000158464 (rank : 17)	NC score	0.676001 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH3_MOUSE
θ value	0.00175202 (rank : 18)	NC score	0.503732 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
θ value	0.00228821 (rank : 19)	NC score	0.504382 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	106	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

MAX_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.054705 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	2.36792 (rank : 21)	NC score	0.056916 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	139	Shared Neighborhood Hits	16
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

RABE2_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.013249 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	598	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

SHAN1_HUMAN
θ value	2.36792 (rank : 23)	NC score	0.008517 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	1041	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

HPS6_MOUSE
θ value	3.0926 (rank : 24)	NC score	0.025992 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLY7, Q8BML5, Q8CIA3	Gene names	Hps6, Ru
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein homolog (Ruby-eye protein) (Ru).

MYOD1_HUMAN
θ value	3.0926 (rank : 25)	NC score	0.069858 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.069605 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MAD3_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.044445 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

EAA4_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.012835 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P48664	Gene names	SLC1A6, EAAT4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter).

EAA4_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.012825 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	O35544	Gene names	Slc1a6, Eaat4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter).

MAD1_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.076103 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.092796 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD4_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.063377 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYOG_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.056144 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	67	Shared Neighborhood Hits	9
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.055057 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	71	Shared Neighborhood Hits	9
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

BMAL1_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.087423 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.089591 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MAD4_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.050747 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	65	Shared Neighborhood Hits	10
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MITF_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.087915 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.083624 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.089226 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.089537 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_HUMAN
θ value	θ > 10 (rank : 42)	NC score	0.079918 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.069755 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	384	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.087015 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	133	Shared Neighborhood Hits	22
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFE3_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.090278 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.064542 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	111	Shared Neighborhood Hits	19
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.065651 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.087530 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.087493 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.077818 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.082095 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

HES2_MOUSE
NC score	0.999962 (rank : 1)	θ value	3.35642e-63 (rank : 1)
Query Neighborhood Hits	36	Target Neighborhood Hits	36	Shared Neighborhood Hits	36
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.986247 (rank : 2)	θ value	3.72821e-46 (rank : 2)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES4_HUMAN
NC score	0.925658 (rank : 3)	θ value	4.43474e-23 (rank : 3)
Query Neighborhood Hits	36	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
NC score	0.892437 (rank : 4)	θ value	1.86321e-21 (rank : 4)
Query Neighborhood Hits	36	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.892278 (rank : 5)	θ value	1.86321e-21 (rank : 5)
Query Neighborhood Hits	36	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES5_MOUSE
NC score	0.831350 (rank : 6)	θ value	6.21693e-09 (rank : 12)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
NC score	0.794941 (rank : 7)	θ value	6.64225e-11 (rank : 8)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.788506 (rank : 8)	θ value	3.89403e-11 (rank : 7)
Query Neighborhood Hits	36	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_HUMAN
NC score	0.766543 (rank : 9)	θ value	1.74796e-11 (rank : 6)
Query Neighborhood Hits	36	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.759426 (rank : 10)	θ value	6.64225e-11 (rank : 9)
Query Neighborhood Hits	36	Target Neighborhood Hits	72	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HEY2_MOUSE
NC score	0.724373 (rank : 11)	θ value	5.62301e-10 (rank : 10)
Query Neighborhood Hits	36	Target Neighborhood Hits	80	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.721280 (rank : 12)	θ value	2.13673e-09 (rank : 11)
Query Neighborhood Hits	36	Target Neighborhood Hits	77	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_MOUSE
NC score	0.713370 (rank : 13)	θ value	8.11959e-09 (rank : 14)
Query Neighborhood Hits	36	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.711457 (rank : 14)	θ value	6.21693e-09 (rank : 13)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES3_MOUSE
NC score	0.676001 (rank : 15)	θ value	0.000158464 (rank : 17)
Query Neighborhood Hits	36	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH2_HUMAN
NC score	0.538535 (rank : 16)	θ value	4.92598e-06 (rank : 15)
Query Neighborhood Hits	36	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.513980 (rank : 17)	θ value	7.1131e-05 (rank : 16)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
NC score	0.504382 (rank : 18)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	36	Target Neighborhood Hits	106	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.503732 (rank : 19)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

MAD1_MOUSE
NC score	0.092796 (rank : 20)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	36	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TFE3_HUMAN
NC score	0.090278 (rank : 21)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	36	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

BMAL1_MOUSE
NC score	0.089591 (rank : 22)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	36	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MLX_MOUSE
NC score	0.089537 (rank : 23)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	36	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.089226 (rank : 24)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	36	Target Neighborhood Hits	95	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MITF_HUMAN
NC score	0.087915 (rank : 25)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	36	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

USF1_HUMAN
NC score	0.087530 (rank : 26)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	36	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.087493 (rank : 27)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	36	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

BMAL1_HUMAN
NC score	0.087423 (rank : 28)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	36	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

SRBP2_HUMAN
NC score	0.087015 (rank : 29)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	36	Target Neighborhood Hits	133	Shared Neighborhood Hits	22
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MITF_MOUSE
NC score	0.083624 (rank : 30)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	36	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

USF2_MOUSE
NC score	0.082095 (rank : 31)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	36	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

SRBP1_HUMAN
NC score	0.079918 (rank : 32)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	36	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

USF2_HUMAN
NC score	0.077818 (rank : 33)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	36	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MAD1_HUMAN
NC score	0.076103 (rank : 34)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	36	Target Neighborhood Hits	68	Shared Neighborhood Hits	17
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYOD1_HUMAN
NC score	0.069858 (rank : 35)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	36	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

SRBP1_MOUSE
NC score	0.069755 (rank : 36)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	36	Target Neighborhood Hits	384	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYOD1_MOUSE
NC score	0.069605 (rank : 37)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	36	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

TFEB_MOUSE
NC score	0.065651 (rank : 38)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	36	Target Neighborhood Hits	119	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.064542 (rank : 39)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	36	Target Neighborhood Hits	111	Shared Neighborhood Hits	19
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MAD4_HUMAN
NC score	0.063377 (rank : 40)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	36	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAX_MOUSE
NC score	0.056916 (rank : 41)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	36	Target Neighborhood Hits	139	Shared Neighborhood Hits	16
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MYOG_HUMAN
NC score	0.056144 (rank : 42)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	36	Target Neighborhood Hits	67	Shared Neighborhood Hits	9
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
NC score	0.055057 (rank : 43)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	36	Target Neighborhood Hits	71	Shared Neighborhood Hits	9
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

MAX_HUMAN
NC score	0.054705 (rank : 44)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	36	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAD4_MOUSE
NC score	0.050747 (rank : 45)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	36	Target Neighborhood Hits	65	Shared Neighborhood Hits	10
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD3_HUMAN
NC score	0.044445 (rank : 46)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	36	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

HPS6_MOUSE
NC score	0.025992 (rank : 47)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	36	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BLY7, Q8BML5, Q8CIA3	Gene names	Hps6, Ru
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 6 protein homolog (Ruby-eye protein) (Ru).

RABE2_MOUSE
NC score	0.013249 (rank : 48)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	36	Target Neighborhood Hits	598	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

EAA4_HUMAN
NC score	0.012835 (rank : 49)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	36	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P48664	Gene names	SLC1A6, EAAT4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter).

EAA4_MOUSE
NC score	0.012825 (rank : 50)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	36	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	O35544	Gene names	Slc1a6, Eaat4
Domain Architecture
Description	Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (High-affinity neuronal glutamate transporter).

SHAN1_HUMAN
NC score	0.008517 (rank : 51)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	36	Target Neighborhood Hits	1041	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).