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Network neighborhood for query Sequence : BHLH3_MOUSE

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BHLH3_MOUSE
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BHLH3_MOUSE
θ value	1.72687e-168 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
θ value	1.34075e-120 (rank : 2)	NC score	0.981441 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH2_MOUSE
θ value	9.76566e-63 (rank : 3)	NC score	0.935672 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH2_HUMAN
θ value	4.10295e-61 (rank : 4)	NC score	0.927145 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

HES4_HUMAN
θ value	6.21693e-09 (rank : 5)	NC score	0.607797 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
θ value	1.80886e-08 (rank : 6)	NC score	0.582997 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	1.80886e-08 (rank : 7)	NC score	0.581614 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	39
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HEY2_MOUSE
θ value	6.87365e-08 (rank : 8)	NC score	0.561823 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
θ value	8.97725e-08 (rank : 9)	NC score	0.557551 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_MOUSE
θ value	4.45536e-07 (rank : 10)	NC score	0.550732 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
θ value	7.59969e-07 (rank : 11)	NC score	0.543188 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES5_MOUSE
θ value	1.09739e-05 (rank : 12)	NC score	0.574536 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	29
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES2_HUMAN
θ value	0.00175202 (rank : 13)	NC score	0.500097 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	0.00175202 (rank : 14)	NC score	0.503732 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	0.00228821 (rank : 15)	NC score	0.477905 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES6_HUMAN
θ value	0.00869519 (rank : 16)	NC score	0.443490 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

BMAL1_HUMAN
θ value	0.0252991 (rank : 17)	NC score	0.180500 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.0252991 (rank : 18)	NC score	0.181617 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	121	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MXI1_HUMAN
θ value	0.0330416 (rank : 19)	NC score	0.186973 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	0.0330416 (rank : 20)	NC score	0.185644 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

HES6_MOUSE
θ value	0.0736092 (rank : 21)	NC score	0.421335 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

MAD1_MOUSE
θ value	0.0736092 (rank : 22)	NC score	0.195164 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_MOUSE
θ value	0.0736092 (rank : 23)	NC score	0.188377 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	384	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_HUMAN
θ value	0.0961366 (rank : 24)	NC score	0.193875 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

USF1_HUMAN
θ value	0.125558 (rank : 25)	NC score	0.228078 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.125558 (rank : 26)	NC score	0.228094 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MAD1_HUMAN
θ value	0.163984 (rank : 27)	NC score	0.185123 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	28
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

BCL9_HUMAN
θ value	0.21417 (rank : 28)	NC score	0.047616 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	1008	Shared Neighborhood Hits	12
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

HES7_HUMAN
θ value	0.21417 (rank : 29)	NC score	0.370824 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	0.21417 (rank : 30)	NC score	0.385187 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MLX_HUMAN
θ value	0.279714 (rank : 31)	NC score	0.202722 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	0.279714 (rank : 32)	NC score	0.204986 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

BCL9_MOUSE
θ value	0.365318 (rank : 33)	NC score	0.049230 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	770	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

ARNT_MOUSE
θ value	0.47712 (rank : 34)	NC score	0.132499 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

TFE3_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.182951 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

CLOCK_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.118888 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MYCL1_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.107032 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.111931 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SRBP2_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.192830 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	133	Shared Neighborhood Hits	42
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF2_MOUSE
θ value	1.06291 (rank : 40)	NC score	0.195492 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

CLOCK_MOUSE
θ value	1.38821 (rank : 41)	NC score	0.115418 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MYST4_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.014047 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	671	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

USF2_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.191900 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MAD3_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.143988 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

NPAS2_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.108672 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	150	Shared Neighborhood Hits	32
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	1.81305 (rank : 46)	NC score	0.108355 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

PP2CG_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.020273 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

ARNT2_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.124663 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.129075 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.127798 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

DGKK_HUMAN
θ value	3.0926 (rank : 51)	NC score	0.015458 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	378	Shared Neighborhood Hits	7
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

IF4G1_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.018330 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	534	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

MITF_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.154491 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.140966 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	111	Shared Neighborhood Hits	44
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.142963 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	119	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MAGD4_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.008764 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	338	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

MITF_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.157469 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	48
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

SRRM2_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.011001 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	1296	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TRI29_HUMAN
θ value	4.03905 (rank : 59)	NC score	0.011312 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	273	Shared Neighborhood Hits	2
SwissProt Accessions	Q14134, Q96AA9, Q9BZY7	Gene names	TRIM29, ATDC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29 (Ataxia-telangiectasia group D- associated protein).

CBP_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.015432 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	941	Shared Neighborhood Hits	12
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

RGL2_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.011614 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

TTLL4_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.012433 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

AMPH_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.012259 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

MYC_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.086308 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

P3C2A_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.005675 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

CMTA2_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.009104 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MAD3_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.120488 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD4_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.148468 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MKL1_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.013367 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	667	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NEB2_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.002371 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	883	Shared Neighborhood Hits	2
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

CN048_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.050671 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCU1, Q8N7S1	Gene names	C14orf48
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf48.

MAD4_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.105211 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAX_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.088910 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.089490 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MNT_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.051924 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	496	Shared Neighborhood Hits	30
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.054953 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	432	Shared Neighborhood Hits	29
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCN_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.056521 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.058417 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TCFL5_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.054346 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

Hits sorted by NC score

BHLH3_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.72687e-168 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
NC score	0.981441 (rank : 2)	θ value	1.34075e-120 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	54
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH2_MOUSE
NC score	0.935672 (rank : 3)	θ value	9.76566e-63 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH2_HUMAN
NC score	0.927145 (rank : 4)	θ value	4.10295e-61 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	53
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

HES4_HUMAN
NC score	0.607797 (rank : 5)	θ value	6.21693e-09 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
NC score	0.582997 (rank : 6)	θ value	1.80886e-08 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.581614 (rank : 7)	θ value	1.80886e-08 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	39
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES5_MOUSE
NC score	0.574536 (rank : 8)	θ value	1.09739e-05 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	29
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY2_MOUSE
NC score	0.561823 (rank : 9)	θ value	6.87365e-08 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.557551 (rank : 10)	θ value	8.97725e-08 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_MOUSE
NC score	0.550732 (rank : 11)	θ value	4.45536e-07 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.543188 (rank : 12)	θ value	7.59969e-07 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES2_MOUSE
NC score	0.503732 (rank : 13)	θ value	0.00175202 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.500097 (rank : 14)	θ value	0.00175202 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
NC score	0.477905 (rank : 15)	θ value	0.00228821 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES6_HUMAN
NC score	0.443490 (rank : 16)	θ value	0.00869519 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.421335 (rank : 17)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_MOUSE
NC score	0.385187 (rank : 18)	θ value	0.21417 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
NC score	0.370824 (rank : 19)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

USF1_MOUSE
NC score	0.228094 (rank : 20)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.228078 (rank : 21)	θ value	0.125558 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	44
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MLX_MOUSE
NC score	0.204986 (rank : 22)	θ value	0.279714 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.202722 (rank : 23)	θ value	0.279714 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF2_MOUSE
NC score	0.195492 (rank : 24)	θ value	1.06291 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MAD1_MOUSE
NC score	0.195164 (rank : 25)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	75	Shared Neighborhood Hits	28
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_HUMAN
NC score	0.193875 (rank : 26)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
NC score	0.192830 (rank : 27)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	133	Shared Neighborhood Hits	42
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF2_HUMAN
NC score	0.191900 (rank : 28)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	43
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

SRBP1_MOUSE
NC score	0.188377 (rank : 29)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	384	Shared Neighborhood Hits	48
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MXI1_HUMAN
NC score	0.186973 (rank : 30)	θ value	0.0330416 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
NC score	0.185644 (rank : 31)	θ value	0.0330416 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	29
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD1_HUMAN
NC score	0.185123 (rank : 32)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	28
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TFE3_HUMAN
NC score	0.182951 (rank : 33)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

BMAL1_MOUSE
NC score	0.181617 (rank : 34)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	121	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.180500 (rank : 35)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MITF_MOUSE
NC score	0.157469 (rank : 36)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	48
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.154491 (rank : 37)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	48
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MAD4_HUMAN
NC score	0.148468 (rank : 38)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	36
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD3_HUMAN
NC score	0.143988 (rank : 39)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

TFEB_MOUSE
NC score	0.142963 (rank : 40)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	119	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.140966 (rank : 41)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	111	Shared Neighborhood Hits	44
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

ARNT_MOUSE
NC score	0.132499 (rank : 42)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_MOUSE
NC score	0.129075 (rank : 43)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.127798 (rank : 44)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
NC score	0.124663 (rank : 45)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MAD3_MOUSE
NC score	0.120488 (rank : 46)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	26
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

CLOCK_HUMAN
NC score	0.118888 (rank : 47)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.115418 (rank : 48)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	148	Shared Neighborhood Hits	32
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MYCL1_MOUSE
NC score	0.111931 (rank : 49)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

NPAS2_HUMAN
NC score	0.108672 (rank : 50)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	150	Shared Neighborhood Hits	32
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.108355 (rank : 51)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

MYCL1_HUMAN
NC score	0.107032 (rank : 52)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MAD4_MOUSE
NC score	0.105211 (rank : 53)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAX_MOUSE
NC score	0.089490 (rank : 54)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	36
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.088910 (rank : 55)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYC_HUMAN
NC score	0.086308 (rank : 56)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
NC score	0.058417 (rank : 57)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_MOUSE
NC score	0.056521 (rank : 58)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MNT_MOUSE
NC score	0.054953 (rank : 59)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	432	Shared Neighborhood Hits	29
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

TCFL5_HUMAN
NC score	0.054346 (rank : 60)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	70	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MNT_HUMAN
NC score	0.051924 (rank : 61)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	496	Shared Neighborhood Hits	30
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

CN048_HUMAN
NC score	0.050671 (rank : 62)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCU1, Q8N7S1	Gene names	C14orf48
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf48.

BCL9_MOUSE
NC score	0.049230 (rank : 63)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	770	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BCL9_HUMAN
NC score	0.047616 (rank : 64)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	1008	Shared Neighborhood Hits	12
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

PP2CG_MOUSE
NC score	0.020273 (rank : 65)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q61074	Gene names	Ppm1g, Fin13, Ppm1c
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C) (Fibroblast growth factor-inducible protein 13) (FIN13).

IF4G1_MOUSE
NC score	0.018330 (rank : 66)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	534	Shared Neighborhood Hits	9
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

DGKK_HUMAN
NC score	0.015458 (rank : 67)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	378	Shared Neighborhood Hits	7
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

CBP_HUMAN
NC score	0.015432 (rank : 68)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	941	Shared Neighborhood Hits	12
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

MYST4_HUMAN
NC score	0.014047 (rank : 69)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	671	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

MKL1_MOUSE
NC score	0.013367 (rank : 70)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	667	Shared Neighborhood Hits	12
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

TTLL4_MOUSE
NC score	0.012433 (rank : 71)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	103	Shared Neighborhood Hits	3
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

AMPH_HUMAN
NC score	0.012259 (rank : 72)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	455	Shared Neighborhood Hits	7
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

RGL2_MOUSE
NC score	0.011614 (rank : 73)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q61193, Q9QUJ2	Gene names	Rgl2, Rab2l, Rlf
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like factor) (RAS-associated protein RAB2L).

TRI29_HUMAN
NC score	0.011312 (rank : 74)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	273	Shared Neighborhood Hits	2
SwissProt Accessions	Q14134, Q96AA9, Q9BZY7	Gene names	TRIM29, ATDC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 29 (Ataxia-telangiectasia group D- associated protein).

SRRM2_HUMAN
NC score	0.011001 (rank : 75)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	1296	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CMTA2_HUMAN
NC score	0.009104 (rank : 76)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	199	Shared Neighborhood Hits	2
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

MAGD4_HUMAN
NC score	0.008764 (rank : 77)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	338	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

P3C2A_HUMAN
NC score	0.005675 (rank : 78)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	188	Shared Neighborhood Hits	2
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

NEB2_HUMAN
NC score	0.002371 (rank : 79)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	883	Shared Neighborhood Hits	2
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).