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Network neighborhood for query Sequence : HES6_HUMAN

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HES6_HUMAN
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES6_HUMAN
θ value	9.34977e-98 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	1.00126e-91 (rank : 2)	NC score	0.991294 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES1_HUMAN
θ value	1.80466e-16 (rank : 3)	NC score	0.798671 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	1.80466e-16 (rank : 4)	NC score	0.799255 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES4_HUMAN
θ value	9.90251e-15 (rank : 5)	NC score	0.818421 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_MOUSE
θ value	6.64225e-11 (rank : 6)	NC score	0.794941 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
θ value	1.9326e-10 (rank : 7)	NC score	0.784409 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HEY1_HUMAN
θ value	2.52405e-10 (rank : 8)	NC score	0.683499 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	2.52405e-10 (rank : 9)	NC score	0.686505 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	7.34386e-10 (rank : 10)	NC score	0.684417 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	9.59137e-10 (rank : 11)	NC score	0.684061 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES7_HUMAN
θ value	2.21117e-06 (rank : 12)	NC score	0.641857 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	2.21117e-06 (rank : 13)	NC score	0.633060 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES5_MOUSE
θ value	3.77169e-06 (rank : 14)	NC score	0.722615 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

BHLH2_HUMAN
θ value	3.19293e-05 (rank : 15)	NC score	0.478629 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	0.000602161 (rank : 16)	NC score	0.458028 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	22
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.450532 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	106	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

HES3_MOUSE
θ value	0.00509761 (rank : 18)	NC score	0.575043 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH3_MOUSE
θ value	0.00869519 (rank : 19)	NC score	0.443490 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

SRBP1_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.133145 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	384	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.146273 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	225	Shared Neighborhood Hits	23
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

GATA6_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.024148 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

SQSTM_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.039968 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

B4GT1_HUMAN
θ value	1.38821 (rank : 24)	NC score	0.027756 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

MITF_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.119460 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	113	Shared Neighborhood Hits	21
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MYOD1_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.074972 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	100	Shared Neighborhood Hits	9
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.073315 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

GNAS1_MOUSE
θ value	1.81305 (rank : 28)	NC score	0.011763 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	651	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

KCNH6_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.012947 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

PLEC1_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.006345 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	1326	Shared Neighborhood Hits	6
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

DPF3_MOUSE
θ value	3.0926 (rank : 31)	NC score	0.033496 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	327	Shared Neighborhood Hits	4
SwissProt Accessions	P58269	Gene names	Dpf3, Cerd4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein Dpf3 (cer-d4).

GCH1_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.031612 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

LGMN_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.033956 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q99538, O00123	Gene names	LGMN, PRSC1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

CK5P2_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.008653 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	1433	Shared Neighborhood Hits	6
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

JIP2_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.016802 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ASTL_HUMAN
θ value	5.27518 (rank : 36)	NC score	0.014655 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	252	Shared Neighborhood Hits	5
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

DPF3_HUMAN
θ value	5.27518 (rank : 37)	NC score	0.038010 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q92784, Q9H7Y5	Gene names	DPF3, CERD4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein DPF3 (cer-d4).

SRBP2_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.139254 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	133	Shared Neighborhood Hits	20
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MILK1_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.011516 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	427	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

OBSCN_HUMAN
θ value	6.88961 (rank : 40)	NC score	-0.001640 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	1931	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

RIMB1_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.010104 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	1479	Shared Neighborhood Hits	11
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SON_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.013912 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	1568	Shared Neighborhood Hits	17
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SYTL2_MOUSE
θ value	6.88961 (rank : 43)	NC score	0.010132 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	253	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

ADA19_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.002720 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

CTHR1_HUMAN
θ value	8.99809 (rank : 45)	NC score	0.014412 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q96CG8, Q6UW91, Q8IX63	Gene names	CTHRC1
Domain Architecture	No domain graphic available
Description	Collagen triple helix repeat-containing protein 1 precursor (NMTC1 protein).

CTHR1_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.014397 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1D6	Gene names	Cthrc1
Domain Architecture	No domain graphic available
Description	Collagen triple helix repeat-containing protein 1 precursor.

TFEB_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.088051 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	8.99809 (rank : 48)	NC score	0.089279 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	119	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TLX3_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.002157 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	403	Shared Neighborhood Hits	2
SwissProt Accessions	O43711, Q96AD3	Gene names	TLX3, HOX11L2
Domain Architecture
Description	T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2).

BMAL1_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.069840 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.072294 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MAD1_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.052337 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MITF_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.102111 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.088625 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	95	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.089538 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TFE3_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.102476 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.084966 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.084973 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.076359 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.079895 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	173	Shared Neighborhood Hits	18
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

HES6_HUMAN
NC score	0.999962 (rank : 1)	θ value	9.34977e-98 (rank : 1)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	49
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.991294 (rank : 2)	θ value	1.00126e-91 (rank : 2)
Query Neighborhood Hits	49	Target Neighborhood Hits	49	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES4_HUMAN
NC score	0.818421 (rank : 3)	θ value	9.90251e-15 (rank : 5)
Query Neighborhood Hits	49	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_MOUSE
NC score	0.799255 (rank : 4)	θ value	1.80466e-16 (rank : 4)
Query Neighborhood Hits	49	Target Neighborhood Hits	78	Shared Neighborhood Hits	28
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.798671 (rank : 5)	θ value	1.80466e-16 (rank : 3)
Query Neighborhood Hits	49	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES2_MOUSE
NC score	0.794941 (rank : 6)	θ value	6.64225e-11 (rank : 6)
Query Neighborhood Hits	49	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.784409 (rank : 7)	θ value	1.9326e-10 (rank : 7)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES5_MOUSE
NC score	0.722615 (rank : 8)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_MOUSE
NC score	0.686505 (rank : 9)	θ value	2.52405e-10 (rank : 9)
Query Neighborhood Hits	49	Target Neighborhood Hits	69	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
NC score	0.684417 (rank : 10)	θ value	7.34386e-10 (rank : 10)
Query Neighborhood Hits	49	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.684061 (rank : 11)	θ value	9.59137e-10 (rank : 11)
Query Neighborhood Hits	49	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_HUMAN
NC score	0.683499 (rank : 12)	θ value	2.52405e-10 (rank : 8)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	25
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES7_HUMAN
NC score	0.641857 (rank : 13)	θ value	2.21117e-06 (rank : 12)
Query Neighborhood Hits	49	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.633060 (rank : 14)	θ value	2.21117e-06 (rank : 13)
Query Neighborhood Hits	49	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES3_MOUSE
NC score	0.575043 (rank : 15)	θ value	0.00509761 (rank : 18)
Query Neighborhood Hits	49	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH2_HUMAN
NC score	0.478629 (rank : 16)	θ value	3.19293e-05 (rank : 15)
Query Neighborhood Hits	49	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.458028 (rank : 17)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	22
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
NC score	0.450532 (rank : 18)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	49	Target Neighborhood Hits	106	Shared Neighborhood Hits	25
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.443490 (rank : 19)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

SRBP1_HUMAN
NC score	0.146273 (rank : 20)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	49	Target Neighborhood Hits	225	Shared Neighborhood Hits	23
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
NC score	0.139254 (rank : 21)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	49	Target Neighborhood Hits	133	Shared Neighborhood Hits	20
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_MOUSE
NC score	0.133145 (rank : 22)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	49	Target Neighborhood Hits	384	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MITF_HUMAN
NC score	0.119460 (rank : 23)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	49	Target Neighborhood Hits	113	Shared Neighborhood Hits	21
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.102476 (rank : 24)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	49	Target Neighborhood Hits	190	Shared Neighborhood Hits	18
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_MOUSE
NC score	0.102111 (rank : 25)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_MOUSE
NC score	0.089538 (rank : 26)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	49	Target Neighborhood Hits	100	Shared Neighborhood Hits	13
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TFEB_MOUSE
NC score	0.089279 (rank : 27)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	49	Target Neighborhood Hits	119	Shared Neighborhood Hits	21
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MLX_HUMAN
NC score	0.088625 (rank : 28)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	49	Target Neighborhood Hits	95	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TFEB_HUMAN
NC score	0.088051 (rank : 29)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	49	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

USF1_MOUSE
NC score	0.084973 (rank : 30)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	49	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.084966 (rank : 31)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	49	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
NC score	0.079895 (rank : 32)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	49	Target Neighborhood Hits	173	Shared Neighborhood Hits	18
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.076359 (rank : 33)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	49	Target Neighborhood Hits	155	Shared Neighborhood Hits	17
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MYOD1_HUMAN
NC score	0.074972 (rank : 34)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	49	Target Neighborhood Hits	100	Shared Neighborhood Hits	9
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
NC score	0.073315 (rank : 35)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

BMAL1_MOUSE
NC score	0.072294 (rank : 36)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	49	Target Neighborhood Hits	121	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.069840 (rank : 37)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	49	Target Neighborhood Hits	115	Shared Neighborhood Hits	22
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MAD1_MOUSE
NC score	0.052337 (rank : 38)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	49	Target Neighborhood Hits	75	Shared Neighborhood Hits	10
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SQSTM_MOUSE
NC score	0.039968 (rank : 39)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	49	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

DPF3_HUMAN
NC score	0.038010 (rank : 40)	θ value	5.27518 (rank : 37)
Query Neighborhood Hits	49	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q92784, Q9H7Y5	Gene names	DPF3, CERD4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein DPF3 (cer-d4).

LGMN_HUMAN
NC score	0.033956 (rank : 41)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	49	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q99538, O00123	Gene names	LGMN, PRSC1
Domain Architecture
Description	Legumain precursor (EC 3.4.22.34) (Asparaginyl endopeptidase) (Protease, cysteine 1).

DPF3_MOUSE
NC score	0.033496 (rank : 42)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	49	Target Neighborhood Hits	327	Shared Neighborhood Hits	4
SwissProt Accessions	P58269	Gene names	Dpf3, Cerd4
Domain Architecture	No domain graphic available
Description	Zinc-finger protein Dpf3 (cer-d4).

GCH1_HUMAN
NC score	0.031612 (rank : 43)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	49	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30793, Q9Y4I8	Gene names	GCH1, DYT5, GCH
Domain Architecture
Description	GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).

B4GT1_HUMAN
NC score	0.027756 (rank : 44)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	49	Target Neighborhood Hits	168	Shared Neighborhood Hits	4
SwissProt Accessions	P15291, Q12909, Q12910, Q12911, Q14456, Q14509, Q14523	Gene names	B4GALT1, GGTB2
Domain Architecture
Description	Beta-1,4-galactosyltransferase 1 (EC 2.4.1.-) (Beta-1,4-GalTase 1) (Beta4Gal-T1) (b4Gal-T1) (UDP-galactose:beta-N-acetylglucosamine beta- 1,4-galactosyltransferase 1) (UDP-Gal:beta-GlcNAc beta-1,4- galactosyltransferase 1) [Includes: Lactose synthase A protein (EC 2.4.1.22); N-acetyllactosamine synthase (EC 2.4.1.90) (Nal synthetase); Beta-N-acetylglucosaminylglycopeptide beta-1,4- galactosyltransferase (EC 2.4.1.38); Beta-N-acetylglucosaminyl- glycolipid beta-1,4-galactosyltransferase (EC 2.4.1.-)].

GATA6_HUMAN
NC score	0.024148 (rank : 45)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	49	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q92908, P78327	Gene names	GATA6
Domain Architecture
Description	Transcription factor GATA-6 (GATA-binding factor 6).

JIP2_HUMAN
NC score	0.016802 (rank : 46)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	49	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ASTL_HUMAN
NC score	0.014655 (rank : 47)	θ value	5.27518 (rank : 36)
Query Neighborhood Hits	49	Target Neighborhood Hits	252	Shared Neighborhood Hits	5
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

CTHR1_HUMAN
NC score	0.014412 (rank : 48)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	49	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	Q96CG8, Q6UW91, Q8IX63	Gene names	CTHRC1
Domain Architecture	No domain graphic available
Description	Collagen triple helix repeat-containing protein 1 precursor (NMTC1 protein).

CTHR1_MOUSE
NC score	0.014397 (rank : 49)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	49	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D1D6	Gene names	Cthrc1
Domain Architecture	No domain graphic available
Description	Collagen triple helix repeat-containing protein 1 precursor.

SON_HUMAN
NC score	0.013912 (rank : 50)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	49	Target Neighborhood Hits	1568	Shared Neighborhood Hits	17
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

KCNH6_HUMAN
NC score	0.012947 (rank : 51)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	49	Target Neighborhood Hits	222	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

GNAS1_MOUSE
NC score	0.011763 (rank : 52)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	49	Target Neighborhood Hits	651	Shared Neighborhood Hits	6
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

MILK1_HUMAN
NC score	0.011516 (rank : 53)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	49	Target Neighborhood Hits	427	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SYTL2_MOUSE
NC score	0.010132 (rank : 54)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	49	Target Neighborhood Hits	253	Shared Neighborhood Hits	3
SwissProt Accessions	Q99N50, Q8BT37, Q99J89, Q99J90, Q99N51, Q99N52, Q99N55, Q99N56	Gene names	Sytl2, Slp2
Domain Architecture
Description	Synaptotagmin-like protein 2 (Exophilin-4).

RIMB1_HUMAN
NC score	0.010104 (rank : 55)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	49	Target Neighborhood Hits	1479	Shared Neighborhood Hits	11
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CK5P2_HUMAN
NC score	0.008653 (rank : 56)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	49	Target Neighborhood Hits	1433	Shared Neighborhood Hits	6
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

PLEC1_HUMAN
NC score	0.006345 (rank : 57)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	49	Target Neighborhood Hits	1326	Shared Neighborhood Hits	6
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

ADA19_MOUSE
NC score	0.002720 (rank : 58)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	49	Target Neighborhood Hits	315	Shared Neighborhood Hits	3
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

TLX3_HUMAN
NC score	0.002157 (rank : 59)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	49	Target Neighborhood Hits	403	Shared Neighborhood Hits	2
SwissProt Accessions	O43711, Q96AD3	Gene names	TLX3, HOX11L2
Domain Architecture
Description	T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2).

OBSCN_HUMAN
NC score	-0.001640 (rank : 60)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	49	Target Neighborhood Hits	1931	Shared Neighborhood Hits	5
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).