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Network neighborhood for query Sequence : BMAL1_HUMAN

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BMAL1_HUMAN
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BMAL1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0 (rank : 2)	NC score	0.998707 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	121	Shared Neighborhood Hits	109
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT_MOUSE
θ value	4.65103e-89 (rank : 3)	NC score	0.924801 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	213	Shared Neighborhood Hits	70
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_HUMAN
θ value	7.93343e-89 (rank : 4)	NC score	0.940974 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
θ value	1.49618e-87 (rank : 5)	NC score	0.941435 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	1.95407e-87 (rank : 6)	NC score	0.941129 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

CLOCK_MOUSE
θ value	1.16164e-39 (rank : 7)	NC score	0.856373 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
θ value	2.58786e-39 (rank : 8)	NC score	0.856452 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	64
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

NPAS2_HUMAN
θ value	1.20211e-36 (rank : 9)	NC score	0.844131 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	62
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	3.4976e-36 (rank : 10)	NC score	0.844334 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	61
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

EPAS1_HUMAN
θ value	1.0531e-32 (rank : 11)	NC score	0.830571 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

HIF1A_MOUSE
θ value	1.0531e-32 (rank : 12)	NC score	0.825732 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
θ value	1.37539e-32 (rank : 13)	NC score	0.824301 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_MOUSE
θ value	1.98606e-31 (rank : 14)	NC score	0.829322 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

SIM1_MOUSE
θ value	4.89182e-30 (rank : 15)	NC score	0.799101 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
θ value	6.38894e-30 (rank : 16)	NC score	0.799917 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	62	Shared Neighborhood Hits	43
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM2_HUMAN
θ value	3.50572e-28 (rank : 17)	NC score	0.793198 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	2.27234e-27 (rank : 18)	NC score	0.793017 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	40
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
θ value	6.18819e-25 (rank : 19)	NC score	0.759744 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	1.5242e-23 (rank : 20)	NC score	0.754424 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
θ value	1.6852e-22 (rank : 21)	NC score	0.747095 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
θ value	3.17815e-21 (rank : 22)	NC score	0.743139 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_MOUSE
θ value	1.33526e-19 (rank : 23)	NC score	0.732313 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_HUMAN
θ value	6.62687e-19 (rank : 24)	NC score	0.740904 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA3_HUMAN
θ value	2.5182e-18 (rank : 25)	NC score	0.604957 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PER3_MOUSE
θ value	1.63225e-17 (rank : 26)	NC score	0.521677 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_MOUSE
θ value	2.13179e-17 (rank : 27)	NC score	0.476773 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	325	Shared Neighborhood Hits	28
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER2_HUMAN
θ value	6.20254e-17 (rank : 28)	NC score	0.504131 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

NCOA1_HUMAN
θ value	1.058e-16 (rank : 29)	NC score	0.641504 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	2.35696e-16 (rank : 30)	NC score	0.644918 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	196	Shared Neighborhood Hits	48
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

PER3_HUMAN
θ value	3.07829e-16 (rank : 31)	NC score	0.477558 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	479	Shared Neighborhood Hits	30
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER1_MOUSE
θ value	1.86753e-13 (rank : 32)	NC score	0.488117 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER1_HUMAN
θ value	4.16044e-13 (rank : 33)	NC score	0.490768 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	215	Shared Neighborhood Hits	29
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

NCOA2_MOUSE
θ value	7.09661e-13 (rank : 34)	NC score	0.566906 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_MOUSE
θ value	7.09661e-13 (rank : 35)	NC score	0.561634 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NCOA2_HUMAN
θ value	2.0648e-12 (rank : 36)	NC score	0.566178 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS4_MOUSE
θ value	1.38499e-08 (rank : 37)	NC score	0.547213 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NPAS4_HUMAN
θ value	1.80886e-08 (rank : 38)	NC score	0.561663 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

HEY2_HUMAN
θ value	1.09739e-05 (rank : 39)	NC score	0.284695 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

USF2_HUMAN
θ value	5.44631e-05 (rank : 40)	NC score	0.261539 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

HEY1_HUMAN
θ value	9.29e-05 (rank : 41)	NC score	0.266126 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY2_MOUSE
θ value	9.29e-05 (rank : 42)	NC score	0.279833 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
θ value	0.000121331 (rank : 43)	NC score	0.272955 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

USF2_MOUSE
θ value	0.00020696 (rank : 44)	NC score	0.252104 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MLX_MOUSE
θ value	0.000461057 (rank : 45)	NC score	0.224782 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF1_HUMAN
θ value	0.000461057 (rank : 46)	NC score	0.264899 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.000461057 (rank : 47)	NC score	0.264694 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MLX_HUMAN
θ value	0.000602161 (rank : 48)	NC score	0.220625 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MITF_HUMAN
θ value	0.00228821 (rank : 49)	NC score	0.235612 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	51
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	0.00390308 (rank : 50)	NC score	0.238086 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	52
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
θ value	0.00869519 (rank : 51)	NC score	0.230472 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	47
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	0.00869519 (rank : 52)	NC score	0.231011 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

SRBP1_MOUSE
θ value	0.0113563 (rank : 53)	NC score	0.151416 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	384	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TCFL5_HUMAN
θ value	0.0113563 (rank : 54)	NC score	0.205864 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	0.0193708 (rank : 55)	NC score	0.239548 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

BHLH2_HUMAN
θ value	0.0252991 (rank : 56)	NC score	0.171285 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	48
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_HUMAN
θ value	0.0252991 (rank : 57)	NC score	0.182104 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	0.0252991 (rank : 58)	NC score	0.180500 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

SRBP1_HUMAN
θ value	0.0252991 (rank : 59)	NC score	0.163788 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAD4_HUMAN
θ value	0.0431538 (rank : 60)	NC score	0.137252 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

BHLH2_MOUSE
θ value	0.0736092 (rank : 61)	NC score	0.168582 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

MNT_HUMAN
θ value	0.125558 (rank : 62)	NC score	0.086923 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	496	Shared Neighborhood Hits	35
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	0.125558 (rank : 63)	NC score	0.085306 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	432	Shared Neighborhood Hits	37
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HES1_HUMAN
θ value	0.21417 (rank : 64)	NC score	0.139690 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.21417 (rank : 65)	NC score	0.139851 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MAD4_MOUSE
θ value	0.21417 (rank : 66)	NC score	0.080428 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HES4_HUMAN
θ value	0.365318 (rank : 67)	NC score	0.153142 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	58	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES5_MOUSE
θ value	0.47712 (rank : 68)	NC score	0.169443 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	32
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

NDF6_HUMAN
θ value	0.47712 (rank : 69)	NC score	0.034967 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	16
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
θ value	0.47712 (rank : 70)	NC score	0.035016 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

HEN2_MOUSE
θ value	0.62314 (rank : 71)	NC score	0.053331 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HES3_MOUSE
θ value	0.62314 (rank : 72)	NC score	0.133008 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MYCS_MOUSE
θ value	0.62314 (rank : 73)	NC score	0.087164 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

ZFY27_HUMAN
θ value	0.62314 (rank : 74)	NC score	0.039895 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

CSPG3_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.006906 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	676	Shared Neighborhood Hits	7
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

HEN2_HUMAN
θ value	1.06291 (rank : 76)	NC score	0.051815 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HAND1_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.042702 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

MYCL1_HUMAN
θ value	1.38821 (rank : 78)	NC score	0.125470 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	1.38821 (rank : 79)	NC score	0.131344 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	123	Shared Neighborhood Hits	42
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

FOXH1_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.010664 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

MAD3_MOUSE
θ value	1.81305 (rank : 81)	NC score	0.075101 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

TCF15_HUMAN
θ value	1.81305 (rank : 82)	NC score	0.035744 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

HES7_HUMAN
θ value	2.36792 (rank : 83)	NC score	0.115533 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	2.36792 (rank : 84)	NC score	0.113528 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD1_HUMAN
θ value	2.36792 (rank : 85)	NC score	0.073509 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

PTHB1_HUMAN
θ value	2.36792 (rank : 86)	NC score	0.023792 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

HEN1_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.041011 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
θ value	3.0926 (rank : 88)	NC score	0.043253 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HES2_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.093686 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MAD3_HUMAN
θ value	3.0926 (rank : 90)	NC score	0.089841 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAX_MOUSE
θ value	3.0926 (rank : 91)	NC score	0.154018 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

PASK_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.000591 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

ATOH1_MOUSE
θ value	4.03905 (rank : 93)	NC score	0.028004 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

GATA2_HUMAN
θ value	4.03905 (rank : 94)	NC score	0.006385 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

MAD1_MOUSE
θ value	4.03905 (rank : 95)	NC score	0.079114 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

PTF1A_HUMAN
θ value	4.03905 (rank : 96)	NC score	0.032402 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	23
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
θ value	4.03905 (rank : 97)	NC score	0.032722 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

ATOH1_HUMAN
θ value	5.27518 (rank : 98)	NC score	0.029869 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	97	Shared Neighborhood Hits	21
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

GPTC8_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.015991 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	366	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

HAND1_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.046638 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	29
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

MAX_HUMAN
θ value	5.27518 (rank : 101)	NC score	0.142135 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

PB1_HUMAN
θ value	5.27518 (rank : 102)	NC score	0.014039 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

SYTL4_HUMAN
θ value	5.27518 (rank : 103)	NC score	0.002958 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TCF15_MOUSE
θ value	5.27518 (rank : 104)	NC score	0.028413 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

ZN541_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.014615 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

FBX46_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.014077 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

KIF5C_HUMAN
θ value	6.88961 (rank : 107)	NC score	-0.000647 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	974	Shared Neighborhood Hits	6
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

PTHB1_MOUSE
θ value	6.88961 (rank : 108)	NC score	0.016373 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q811G0, P97498, Q3UMR2, Q7TQH9, Q8BKD7, Q8K0T5	Gene names	Pthb1
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein homolog).

T240L_HUMAN
θ value	6.88961 (rank : 109)	NC score	0.011918 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

YETS2_MOUSE
θ value	6.88961 (rank : 110)	NC score	0.018444 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	278	Shared Neighborhood Hits	5
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ABL1_HUMAN
θ value	8.99809 (rank : 111)	NC score	-0.006224 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	1220	Shared Neighborhood Hits	4
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

HES2_MOUSE
θ value	8.99809 (rank : 112)	NC score	0.087423 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

KIF5C_MOUSE
θ value	8.99809 (rank : 113)	NC score	-0.002166 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	1040	Shared Neighborhood Hits	5
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

MDR3_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.000807 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	P21447	Gene names	Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Domain Architecture
Description	Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1A) (P-glycoprotein 3) (MDR1A).

RP3A_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.002428 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

HES6_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.069840 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.067902 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

MXI1_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.065253 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.065265 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCN_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.079257 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.077291 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	37
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.079255 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.078686 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SRBP2_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.124102 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFAP4_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.052684 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

Hits sorted by NC score

BMAL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.998707 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	121	Shared Neighborhood Hits	109
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT2_HUMAN
NC score	0.941435 (rank : 3)	θ value	1.49618e-87 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.941129 (rank : 4)	θ value	1.95407e-87 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.940974 (rank : 5)	θ value	7.93343e-89 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	70
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.924801 (rank : 6)	θ value	4.65103e-89 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	213	Shared Neighborhood Hits	70
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_HUMAN
NC score	0.856452 (rank : 7)	θ value	2.58786e-39 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	64
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.856373 (rank : 8)	θ value	1.16164e-39 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_MOUSE
NC score	0.844334 (rank : 9)	θ value	3.4976e-36 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	61
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.844131 (rank : 10)	θ value	1.20211e-36 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	62
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

EPAS1_HUMAN
NC score	0.830571 (rank : 11)	θ value	1.0531e-32 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.829322 (rank : 12)	θ value	1.98606e-31 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_MOUSE
NC score	0.825732 (rank : 13)	θ value	1.0531e-32 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.824301 (rank : 14)	θ value	1.37539e-32 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

SIM1_HUMAN
NC score	0.799917 (rank : 15)	θ value	6.38894e-30 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	62	Shared Neighborhood Hits	43
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.799101 (rank : 16)	θ value	4.89182e-30 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
NC score	0.793198 (rank : 17)	θ value	3.50572e-28 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	41
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.793017 (rank : 18)	θ value	2.27234e-27 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	40
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
NC score	0.759744 (rank : 19)	θ value	6.18819e-25 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.754424 (rank : 20)	θ value	1.5242e-23 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
NC score	0.747095 (rank : 21)	θ value	1.6852e-22 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.743139 (rank : 22)	θ value	3.17815e-21 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_HUMAN
NC score	0.740904 (rank : 23)	θ value	6.62687e-19 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.732313 (rank : 24)	θ value	1.33526e-19 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA1_MOUSE
NC score	0.644918 (rank : 25)	θ value	2.35696e-16 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	196	Shared Neighborhood Hits	48
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.641504 (rank : 26)	θ value	1.058e-16 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	47
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.604957 (rank : 27)	θ value	2.5182e-18 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	171	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA2_MOUSE
NC score	0.566906 (rank : 28)	θ value	7.09661e-13 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.566178 (rank : 29)	θ value	2.0648e-12 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	281	Shared Neighborhood Hits	33
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS4_HUMAN
NC score	0.561663 (rank : 30)	θ value	1.80886e-08 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NCOA3_MOUSE
NC score	0.561634 (rank : 31)	θ value	7.09661e-13 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS4_MOUSE
NC score	0.547213 (rank : 32)	θ value	1.38499e-08 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	245	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PER3_MOUSE
NC score	0.521677 (rank : 33)	θ value	1.63225e-17 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	85	Shared Neighborhood Hits	29
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.504131 (rank : 34)	θ value	6.20254e-17 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	170	Shared Neighborhood Hits	26
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.490768 (rank : 35)	θ value	4.16044e-13 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	215	Shared Neighborhood Hits	29
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.488117 (rank : 36)	θ value	1.86753e-13 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	235	Shared Neighborhood Hits	30
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.477558 (rank : 37)	θ value	3.07829e-16 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	479	Shared Neighborhood Hits	30
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.476773 (rank : 38)	θ value	2.13179e-17 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	325	Shared Neighborhood Hits	28
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.284695 (rank : 39)	θ value	1.09739e-05 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	77	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.279833 (rank : 40)	θ value	9.29e-05 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.272955 (rank : 41)	θ value	0.000121331 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	69	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.266126 (rank : 42)	θ value	9.29e-05 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

USF1_HUMAN
NC score	0.264899 (rank : 43)	θ value	0.000461057 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.264694 (rank : 44)	θ value	0.000461057 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.261539 (rank : 45)	θ value	5.44631e-05 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	155	Shared Neighborhood Hits	50
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.252104 (rank : 46)	θ value	0.00020696 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

TFE3_HUMAN
NC score	0.239548 (rank : 47)	θ value	0.0193708 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	190	Shared Neighborhood Hits	46
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_MOUSE
NC score	0.238086 (rank : 48)	θ value	0.00390308 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	52
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.235612 (rank : 49)	θ value	0.00228821 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	51
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.231011 (rank : 50)	θ value	0.00869519 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.230472 (rank : 51)	θ value	0.00869519 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	47
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MLX_MOUSE
NC score	0.224782 (rank : 52)	θ value	0.000461057 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.220625 (rank : 53)	θ value	0.000602161 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TCFL5_HUMAN
NC score	0.205864 (rank : 54)	θ value	0.0113563 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

BHLH3_HUMAN
NC score	0.182104 (rank : 55)	θ value	0.0252991 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	48
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.180500 (rank : 56)	θ value	0.0252991 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_HUMAN
NC score	0.171285 (rank : 57)	θ value	0.0252991 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	80	Shared Neighborhood Hits	48
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

HES5_MOUSE
NC score	0.169443 (rank : 58)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	32
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

BHLH2_MOUSE
NC score	0.168582 (rank : 59)	θ value	0.0736092 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	70	Shared Neighborhood Hits	46
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

SRBP1_HUMAN
NC score	0.163788 (rank : 60)	θ value	0.0252991 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAX_MOUSE
NC score	0.154018 (rank : 61)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

HES4_HUMAN
NC score	0.153142 (rank : 62)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	58	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

SRBP1_MOUSE
NC score	0.151416 (rank : 63)	θ value	0.0113563 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	384	Shared Neighborhood Hits	52
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAX_HUMAN
NC score	0.142135 (rank : 64)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	43
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

HES1_MOUSE
NC score	0.139851 (rank : 65)	θ value	0.21417 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.139690 (rank : 66)	θ value	0.21417 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

MAD4_HUMAN
NC score	0.137252 (rank : 67)	θ value	0.0431538 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HES3_MOUSE
NC score	0.133008 (rank : 68)	θ value	0.62314 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MYCL1_MOUSE
NC score	0.131344 (rank : 69)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	123	Shared Neighborhood Hits	42
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_HUMAN
NC score	0.125470 (rank : 70)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SRBP2_HUMAN
NC score	0.124102 (rank : 71)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

HES7_HUMAN
NC score	0.115533 (rank : 72)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.113528 (rank : 73)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	72	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES2_HUMAN
NC score	0.093686 (rank : 74)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MAD3_HUMAN
NC score	0.089841 (rank : 75)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

HES2_MOUSE
NC score	0.087423 (rank : 76)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MYCS_MOUSE
NC score	0.087164 (rank : 77)	θ value	0.62314 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MNT_HUMAN
NC score	0.086923 (rank : 78)	θ value	0.125558 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	496	Shared Neighborhood Hits	35
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
NC score	0.085306 (rank : 79)	θ value	0.125558 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	432	Shared Neighborhood Hits	37
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MAD4_MOUSE
NC score	0.080428 (rank : 80)	θ value	0.21417 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	65	Shared Neighborhood Hits	22
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYCN_HUMAN
NC score	0.079257 (rank : 81)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_HUMAN
NC score	0.079255 (rank : 82)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAD1_MOUSE
NC score	0.079114 (rank : 83)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYC_MOUSE
NC score	0.078686 (rank : 84)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_MOUSE
NC score	0.077291 (rank : 85)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	37
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MAD3_MOUSE
NC score	0.075101 (rank : 86)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD1_HUMAN
NC score	0.073509 (rank : 87)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

HES6_HUMAN
NC score	0.069840 (rank : 88)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.067902 (rank : 89)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

MXI1_MOUSE
NC score	0.065265 (rank : 90)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
NC score	0.065253 (rank : 91)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

HEN2_MOUSE
NC score	0.053331 (rank : 92)	θ value	0.62314 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

TFAP4_HUMAN
NC score	0.052684 (rank : 93)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

HEN2_HUMAN
NC score	0.051815 (rank : 94)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HAND1_MOUSE
NC score	0.046638 (rank : 95)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	29
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

HEN1_MOUSE
NC score	0.043253 (rank : 96)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	86	Shared Neighborhood Hits	21
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HAND1_HUMAN
NC score	0.042702 (rank : 97)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HEN1_HUMAN
NC score	0.041011 (rank : 98)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	88	Shared Neighborhood Hits	21
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

ZFY27_HUMAN
NC score	0.039895 (rank : 99)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

TCF15_HUMAN
NC score	0.035744 (rank : 100)	θ value	1.81305 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	17
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

NDF6_MOUSE
NC score	0.035016 (rank : 101)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

NDF6_HUMAN
NC score	0.034967 (rank : 102)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	16
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

PTF1A_MOUSE
NC score	0.032722 (rank : 103)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_HUMAN
NC score	0.032402 (rank : 104)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	95	Shared Neighborhood Hits	23
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

ATOH1_HUMAN
NC score	0.029869 (rank : 105)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	97	Shared Neighborhood Hits	21
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

TCF15_MOUSE
NC score	0.028413 (rank : 106)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	16
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

ATOH1_MOUSE
NC score	0.028004 (rank : 107)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

PTHB1_HUMAN
NC score	0.023792 (rank : 108)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q3SYG4, P78514, Q7KYS6, Q7KYS7, Q8N570, Q99844, Q99854, Q9Y699, Q9Y6A0	Gene names	PTHB1, BBS9
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein) (Bardet-Biedl syndrome 9 protein).

YETS2_MOUSE
NC score	0.018444 (rank : 109)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	278	Shared Neighborhood Hits	5
SwissProt Accessions	Q3TUF7, Q6PGF8, Q80TI2, Q8CG86	Gene names	Yeats2, Kiaa1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

PTHB1_MOUSE
NC score	0.016373 (rank : 110)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q811G0, P97498, Q3UMR2, Q7TQH9, Q8BKD7, Q8K0T5	Gene names	Pthb1
Domain Architecture	No domain graphic available
Description	Protein PTHB1 (Parathyroid hormone-responsive B1 gene protein homolog).

GPTC8_HUMAN
NC score	0.015991 (rank : 111)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	366	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

ZN541_HUMAN
NC score	0.014615 (rank : 112)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	203	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

FBX46_MOUSE
NC score	0.014077 (rank : 113)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BG80	Gene names	Fbxo46, Fbx46, Fbxo34l
Domain Architecture	No domain graphic available
Description	F-box only protein 46 (F-box only protein 34-like).

PB1_HUMAN
NC score	0.014039 (rank : 114)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	Q86U86, Q9H2T3, Q9H2T4, Q9H2T5, Q9H301, Q9H314	Gene names	PB1
Domain Architecture	No domain graphic available
Description	Protein polybromo-1 (hPB1) (Polybromo-1D) (BRG1-associated factor 180) (BAF180).

T240L_HUMAN
NC score	0.011918 (rank : 115)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	3
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

FOXH1_MOUSE
NC score	0.010664 (rank : 116)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

CSPG3_HUMAN
NC score	0.006906 (rank : 117)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	676	Shared Neighborhood Hits	7
SwissProt Accessions	O14594, Q9UPK6	Gene names	CSPG3, NCAN, NEUR
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

GATA2_HUMAN
NC score	0.006385 (rank : 118)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P23769, Q9BUJ6	Gene names	GATA2
Domain Architecture
Description	Endothelial transcription factor GATA-2 (GATA-binding protein 2).

SYTL4_HUMAN
NC score	0.002958 (rank : 119)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	138	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

RP3A_HUMAN
NC score	0.002428 (rank : 120)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	305	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

MDR3_MOUSE
NC score	0.000807 (rank : 121)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	P21447	Gene names	Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Domain Architecture
Description	Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1A) (P-glycoprotein 3) (MDR1A).

PASK_MOUSE
NC score	0.000591 (rank : 122)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	867	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KIF5C_HUMAN
NC score	-0.000647 (rank : 123)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	974	Shared Neighborhood Hits	6
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
NC score	-0.002166 (rank : 124)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	1040	Shared Neighborhood Hits	5
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

ABL1_HUMAN
NC score	-0.006224 (rank : 125)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	1220	Shared Neighborhood Hits	4
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).