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Network neighborhood for query Sequence : SIM2_HUMAN

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SIM2_HUMAN
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIM1_HUMAN
θ value	0 (rank : 1)	NC score	0.988909 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	0 (rank : 2)	NC score	0.988506 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	0 (rank : 4)	NC score	0.995700 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	43
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_HUMAN
θ value	2.0926e-81 (rank : 5)	NC score	0.946602 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	2.0926e-81 (rank : 6)	NC score	0.945507 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
θ value	5.8972e-76 (rank : 7)	NC score	0.954256 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

HIF1A_MOUSE
θ value	1.89707e-74 (rank : 8)	NC score	0.936152 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
θ value	9.41505e-74 (rank : 9)	NC score	0.933296 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

NPAS1_HUMAN
θ value	2.09745e-73 (rank : 10)	NC score	0.953012 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

EPAS1_HUMAN
θ value	9.76566e-63 (rank : 11)	NC score	0.924438 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	4.10295e-61 (rank : 12)	NC score	0.923527 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_MOUSE
θ value	1.28732e-30 (rank : 13)	NC score	0.841801 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_HUMAN
θ value	3.17079e-29 (rank : 14)	NC score	0.842738 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_MOUSE
θ value	4.14116e-29 (rank : 15)	NC score	0.791811 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
θ value	3.50572e-28 (rank : 16)	NC score	0.793198 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

ARNT2_HUMAN
θ value	2.77775e-25 (rank : 17)	NC score	0.748487 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	2.77775e-25 (rank : 18)	NC score	0.747171 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

CLOCK_HUMAN
θ value	1.6852e-22 (rank : 19)	NC score	0.760858 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	44
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	2.20094e-22 (rank : 20)	NC score	0.757698 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS4_HUMAN
θ value	2.20094e-22 (rank : 21)	NC score	0.704444 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

ARNT_HUMAN
θ value	3.17815e-21 (rank : 22)	NC score	0.736844 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	3.17815e-21 (rank : 23)	NC score	0.724561 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_MOUSE
θ value	1.2077e-20 (rank : 24)	NC score	0.688795 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	245	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NPAS2_MOUSE
θ value	2.27762e-19 (rank : 25)	NC score	0.735514 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
θ value	5.60996e-18 (rank : 26)	NC score	0.727511 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NCOA1_MOUSE
θ value	5.25075e-16 (rank : 27)	NC score	0.633834 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	40
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	6.85773e-16 (rank : 28)	NC score	0.630315 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
θ value	2.28291e-11 (rank : 29)	NC score	0.556651 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	2.52405e-10 (rank : 30)	NC score	0.554927 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	41
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	1.38499e-08 (rank : 31)	NC score	0.553234 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	1.53129e-07 (rank : 32)	NC score	0.517247 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

BSN_HUMAN
θ value	0.365318 (rank : 33)	NC score	0.031121 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	1537	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ZN645_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.030760 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	265	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

PER2_HUMAN
θ value	0.813845 (rank : 35)	NC score	0.216490 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	1.06291 (rank : 36)	NC score	0.196936 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	325	Shared Neighborhood Hits	27
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

RTN4_HUMAN
θ value	1.06291 (rank : 37)	NC score	0.013308 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

EXOC3_MOUSE
θ value	1.38821 (rank : 38)	NC score	0.024503 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q6KAR6	Gene names	Exoc3, Sec6l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

HXB3_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.005041 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	559	Shared Neighborhood Hits	10
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

US6NL_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.028054 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

HEY2_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.114995 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	1.81305 (rank : 42)	NC score	0.113097 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAGC1_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.031317 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	20
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

PER3_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.202410 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	479	Shared Neighborhood Hits	36
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

WASIP_HUMAN
θ value	1.81305 (rank : 45)	NC score	0.014081 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	458	Shared Neighborhood Hits	16
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

DYN1_MOUSE
θ value	2.36792 (rank : 46)	NC score	0.008335 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

GON4L_MOUSE
θ value	2.36792 (rank : 47)	NC score	0.012214 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HEY1_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.104269 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.107983 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HXB3_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.004251 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	493	Shared Neighborhood Hits	7
SwissProt Accessions	P09026, P10285, Q4PJ06, Q61680	Gene names	Hoxb3, Hox-2.7, Hoxb-3
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2.7) (Homeobox protein MH-23).

NFH_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.006285 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	2247	Shared Neighborhood Hits	29
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CSKI2_HUMAN
θ value	3.0926 (rank : 52)	NC score	0.006111 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	747	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DIDO1_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.009467 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	960	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

NCOA6_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.032161 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	1202	Shared Neighborhood Hits	34
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SMOX_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.008335 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWM0, Q5TE26, Q5TE27, Q6UY28, Q8IX00, Q96LC3, Q96LC4, Q96QT3, Q9BW38, Q9H6H1, Q9NP51, Q9NPY1, Q9NPY2	Gene names	SMOX, C20orf16, SMO
Domain Architecture	No domain graphic available
Description	Spermine oxidase (EC 1.5.3.-) (Polyamine oxidase 1) (PAO-1) (PAOh1).

TAF4_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.010939 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	687	Shared Neighborhood Hits	17
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

ZEP1_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.001185 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	1036	Shared Neighborhood Hits	11
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

BIN1_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.008155 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	335	Shared Neighborhood Hits	8
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

PER3_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.226327 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

TNC6B_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.017178 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	256	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

BCL9_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.015845 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	1008	Shared Neighborhood Hits	28
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

ETV4_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.003184 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

HES5_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.073616 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MAST4_HUMAN
θ value	6.88961 (rank : 64)	NC score	-0.002313 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	1804	Shared Neighborhood Hits	21
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SYNJ1_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.010559 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	498	Shared Neighborhood Hits	20
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SYNJ1_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.009791 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TXLNB_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.001516 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	912	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

WNK2_HUMAN
θ value	6.88961 (rank : 68)	NC score	-0.000749 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	1407	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ANK2_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.002065 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	1615	Shared Neighborhood Hits	25
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DUT_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.011279 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

GPTC3_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.006805 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BIY1	Gene names	Gpatc3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

ILDR1_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.006837 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

NCOR2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.005441 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	870	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NDC1_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.006751 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCB1	Gene names	Tmem48, Ndc1
Domain Architecture	No domain graphic available
Description	Nucleoporin NDC1 (Transmembrane protein 48).

TMPSD_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.000470 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	334	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

US6NL_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.009817 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

MITF_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.069012 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.070716 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	18
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.064821 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.064860 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PER1_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.202517 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	215	Shared Neighborhood Hits	31
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.199271 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	235	Shared Neighborhood Hits	32
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

TCFL5_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.070143 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.069028 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.065360 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.065537 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.065360 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.065330 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.063002 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.059265 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	15
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

SIM2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.995700 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	75	Shared Neighborhood Hits	43
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.988909 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.988506 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

NPAS1_MOUSE
NC score	0.954256 (rank : 5)	θ value	5.8972e-76 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.953012 (rank : 6)	θ value	2.09745e-73 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	33
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS3_HUMAN
NC score	0.946602 (rank : 7)	θ value	2.0926e-81 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.945507 (rank : 8)	θ value	2.0926e-81 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

HIF1A_MOUSE
NC score	0.936152 (rank : 9)	θ value	1.89707e-74 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	37
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.933296 (rank : 10)	θ value	9.41505e-74 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_HUMAN
NC score	0.924438 (rank : 11)	θ value	9.76566e-63 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.923527 (rank : 12)	θ value	4.10295e-61 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_HUMAN
NC score	0.842738 (rank : 13)	θ value	3.17079e-29 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.841801 (rank : 14)	θ value	1.28732e-30 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
NC score	0.793198 (rank : 15)	θ value	3.50572e-28 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.791811 (rank : 16)	θ value	4.14116e-29 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	121	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
NC score	0.760858 (rank : 17)	θ value	1.6852e-22 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	127	Shared Neighborhood Hits	44
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.757698 (rank : 18)	θ value	2.20094e-22 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT2_HUMAN
NC score	0.748487 (rank : 19)	θ value	2.77775e-25 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.747171 (rank : 20)	θ value	2.77775e-25 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.736844 (rank : 21)	θ value	3.17815e-21 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_MOUSE
NC score	0.735514 (rank : 22)	θ value	2.27762e-19 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.727511 (rank : 23)	θ value	5.60996e-18 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_MOUSE
NC score	0.724561 (rank : 24)	θ value	3.17815e-21 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
NC score	0.704444 (rank : 25)	θ value	2.20094e-22 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	214	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.688795 (rank : 26)	θ value	1.2077e-20 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	245	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.633834 (rank : 27)	θ value	5.25075e-16 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	196	Shared Neighborhood Hits	40
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.630315 (rank : 28)	θ value	6.85773e-16 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
NC score	0.556651 (rank : 29)	θ value	2.28291e-11 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	39
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
NC score	0.554927 (rank : 30)	θ value	2.52405e-10 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	281	Shared Neighborhood Hits	41
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
NC score	0.553234 (rank : 31)	θ value	1.38499e-08 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.517247 (rank : 32)	θ value	1.53129e-07 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.226327 (rank : 33)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	25
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.216490 (rank : 34)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.202517 (rank : 35)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	215	Shared Neighborhood Hits	31
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER3_HUMAN
NC score	0.202410 (rank : 36)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	479	Shared Neighborhood Hits	36
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER1_MOUSE
NC score	0.199271 (rank : 37)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	235	Shared Neighborhood Hits	32
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_MOUSE
NC score	0.196936 (rank : 38)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	325	Shared Neighborhood Hits	27
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HEY2_HUMAN
NC score	0.114995 (rank : 39)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.113097 (rank : 40)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.107983 (rank : 41)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.104269 (rank : 42)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES5_MOUSE
NC score	0.073616 (rank : 43)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MITF_MOUSE
NC score	0.070716 (rank : 44)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	18
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TCFL5_HUMAN
NC score	0.070143 (rank : 45)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
NC score	0.069028 (rank : 46)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	190	Shared Neighborhood Hits	14
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_HUMAN
NC score	0.069012 (rank : 47)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.065537 (rank : 48)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
NC score	0.065360 (rank : 49)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

TFEB_HUMAN
NC score	0.065360 (rank : 50)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

USF1_MOUSE
NC score	0.065330 (rank : 51)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MLX_MOUSE
NC score	0.064860 (rank : 52)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.064821 (rank : 53)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF2_HUMAN
NC score	0.063002 (rank : 54)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.059265 (rank : 55)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	173	Shared Neighborhood Hits	15
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

NCOA6_HUMAN
NC score	0.032161 (rank : 56)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	1202	Shared Neighborhood Hits	34
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MAGC1_HUMAN
NC score	0.031317 (rank : 57)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	431	Shared Neighborhood Hits	20
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

BSN_HUMAN
NC score	0.031121 (rank : 58)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	1537	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ZN645_HUMAN
NC score	0.030760 (rank : 59)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	265	Shared Neighborhood Hits	10
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

US6NL_HUMAN
NC score	0.028054 (rank : 60)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

EXOC3_MOUSE
NC score	0.024503 (rank : 61)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	85	Shared Neighborhood Hits	3
SwissProt Accessions	Q6KAR6	Gene names	Exoc3, Sec6l1
Domain Architecture	No domain graphic available
Description	Exocyst complex component 3 (Exocyst complex component Sec6).

TNC6B_HUMAN
NC score	0.017178 (rank : 62)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	256	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

BCL9_HUMAN
NC score	0.015845 (rank : 63)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	1008	Shared Neighborhood Hits	28
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

WASIP_HUMAN
NC score	0.014081 (rank : 64)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	458	Shared Neighborhood Hits	16
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

RTN4_HUMAN
NC score	0.013308 (rank : 65)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	357	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

GON4L_MOUSE
NC score	0.012214 (rank : 66)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	455	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

DUT_HUMAN
NC score	0.011279 (rank : 67)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	P33316, O14785, Q16708, Q16860, Q96Q81	Gene names	DUT
Domain Architecture
Description	Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (EC 3.6.1.23) (dUTPase) (dUTP pyrophosphatase).

TAF4_HUMAN
NC score	0.010939 (rank : 68)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	687	Shared Neighborhood Hits	17
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SYNJ1_HUMAN
NC score	0.010559 (rank : 69)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	498	Shared Neighborhood Hits	20
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

US6NL_MOUSE
NC score	0.009817 (rank : 70)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

SYNJ1_MOUSE
NC score	0.009791 (rank : 71)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

DIDO1_HUMAN
NC score	0.009467 (rank : 72)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	960	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DYN1_MOUSE
NC score	0.008335 (rank : 73)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	168	Shared Neighborhood Hits	7
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

SMOX_HUMAN
NC score	0.008335 (rank : 74)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NWM0, Q5TE26, Q5TE27, Q6UY28, Q8IX00, Q96LC3, Q96LC4, Q96QT3, Q9BW38, Q9H6H1, Q9NP51, Q9NPY1, Q9NPY2	Gene names	SMOX, C20orf16, SMO
Domain Architecture	No domain graphic available
Description	Spermine oxidase (EC 1.5.3.-) (Polyamine oxidase 1) (PAO-1) (PAOh1).

BIN1_HUMAN
NC score	0.008155 (rank : 75)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	335	Shared Neighborhood Hits	8
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

ILDR1_HUMAN
NC score	0.006837 (rank : 76)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

GPTC3_MOUSE
NC score	0.006805 (rank : 77)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BIY1	Gene names	Gpatc3
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 3.

NDC1_MOUSE
NC score	0.006751 (rank : 78)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VCB1	Gene names	Tmem48, Ndc1
Domain Architecture	No domain graphic available
Description	Nucleoporin NDC1 (Transmembrane protein 48).

NFH_MOUSE
NC score	0.006285 (rank : 79)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	2247	Shared Neighborhood Hits	29
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CSKI2_HUMAN
NC score	0.006111 (rank : 80)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	747	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NCOR2_HUMAN
NC score	0.005441 (rank : 81)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	870	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

HXB3_HUMAN
NC score	0.005041 (rank : 82)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	559	Shared Neighborhood Hits	10
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

HXB3_MOUSE
NC score	0.004251 (rank : 83)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	493	Shared Neighborhood Hits	7
SwissProt Accessions	P09026, P10285, Q4PJ06, Q61680	Gene names	Hoxb3, Hox-2.7, Hoxb-3
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2.7) (Homeobox protein MH-23).

ETV4_MOUSE
NC score	0.003184 (rank : 84)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

ANK2_HUMAN
NC score	0.002065 (rank : 85)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	1615	Shared Neighborhood Hits	25
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

TXLNB_HUMAN
NC score	0.001516 (rank : 86)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	912	Shared Neighborhood Hits	11
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ZEP1_HUMAN
NC score	0.001185 (rank : 87)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	1036	Shared Neighborhood Hits	11
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

TMPSD_MOUSE
NC score	0.000470 (rank : 88)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	334	Shared Neighborhood Hits	11
SwissProt Accessions	Q5U405, Q8CFE0, Q91VQ8	Gene names	Tmprss13, Msp
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

WNK2_HUMAN
NC score	-0.000749 (rank : 89)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	1407	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

MAST4_HUMAN
NC score	-0.002313 (rank : 90)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	1804	Shared Neighborhood Hits	21
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).