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Network neighborhood for query Sequence : AHR_HUMAN

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AHR_HUMAN
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AHR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	0 (rank : 2)	NC score	0.993935 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

SIM2_HUMAN
θ value	3.17079e-29 (rank : 3)	NC score	0.842738 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	4.57862e-28 (rank : 4)	NC score	0.838702 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_MOUSE
θ value	5.97985e-28 (rank : 5)	NC score	0.834601 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_MOUSE
θ value	7.80994e-28 (rank : 6)	NC score	0.830453 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM1_HUMAN
θ value	1.33217e-27 (rank : 7)	NC score	0.835341 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

HIF1A_HUMAN
θ value	8.63488e-27 (rank : 8)	NC score	0.826852 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	32
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

NPAS3_MOUSE
θ value	2.51237e-26 (rank : 9)	NC score	0.817248 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	2.77775e-25 (rank : 10)	NC score	0.815377 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

EPAS1_MOUSE
θ value	9.87957e-23 (rank : 11)	NC score	0.815426 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

EPAS1_HUMAN
θ value	1.6852e-22 (rank : 12)	NC score	0.816161 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

CLOCK_HUMAN
θ value	1.5773e-20 (rank : 13)	NC score	0.753697 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	4.58923e-20 (rank : 14)	NC score	0.750577 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

BMAL1_MOUSE
θ value	1.33526e-19 (rank : 15)	NC score	0.740411 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	121	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

NPAS1_HUMAN
θ value	2.27762e-19 (rank : 16)	NC score	0.805712 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

BMAL1_HUMAN
θ value	6.62687e-19 (rank : 17)	NC score	0.740904 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

NPAS2_MOUSE
θ value	4.74913e-17 (rank : 18)	NC score	0.728155 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS1_MOUSE
θ value	1.058e-16 (rank : 19)	NC score	0.801844 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS2_HUMAN
θ value	1.38178e-16 (rank : 20)	NC score	0.721429 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS4_HUMAN
θ value	7.58209e-15 (rank : 21)	NC score	0.660700 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	214	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	2.20605e-14 (rank : 22)	NC score	0.649385 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	245	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA3_HUMAN
θ value	3.52202e-12 (rank : 23)	NC score	0.589777 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA1_HUMAN
θ value	7.84624e-12 (rank : 24)	NC score	0.632270 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	198	Shared Neighborhood Hits	36
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	7.84624e-12 (rank : 25)	NC score	0.634284 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	196	Shared Neighborhood Hits	36
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA2_HUMAN
θ value	8.67504e-11 (rank : 26)	NC score	0.576231 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

ARNT2_HUMAN
θ value	2.52405e-10 (rank : 27)	NC score	0.665594 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NCOA2_MOUSE
θ value	4.30538e-10 (rank : 28)	NC score	0.573492 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

ARNT2_MOUSE
θ value	5.62301e-10 (rank : 29)	NC score	0.663710 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	9.59137e-10 (rank : 30)	NC score	0.660566 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	34
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.63604e-09 (rank : 31)	NC score	0.648789 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	213	Shared Neighborhood Hits	35
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NCOA3_MOUSE
θ value	4.76016e-09 (rank : 32)	NC score	0.551777 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

GCC2_MOUSE
θ value	0.47712 (rank : 33)	NC score	0.002886 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	1619	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

HES5_MOUSE
θ value	1.06291 (rank : 34)	NC score	0.105869 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

PTN22_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.007401 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

HES3_MOUSE
θ value	1.81305 (rank : 36)	NC score	0.081527 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

R3HD2_MOUSE
θ value	4.03905 (rank : 37)	NC score	0.016127 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

ZBT40_HUMAN
θ value	4.03905 (rank : 38)	NC score	-0.002082 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	949	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

MITF_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.080537 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HES7_HUMAN
θ value	6.88961 (rank : 40)	NC score	0.054063 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.052024 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

ITSN2_MOUSE
θ value	6.88961 (rank : 42)	NC score	-0.000676 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	1371	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MITF_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.080130 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

NAF1_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.001728 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	852	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

OXA1L_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.009738 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA9, Q8BK01, Q8R091, Q9D8X7	Gene names	Oxa1l
Domain Architecture
Description	Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein) (OXA1-like protein).

RPA1_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.022382 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	O95602, Q9UEH0, Q9UFT9	Gene names	POLR1A
Domain Architecture
Description	DNA-directed RNA polymerase I largest subunit (EC 2.7.7.6) (RNA polymerase I 194 kDa subunit) (RPA194).

TJAP1_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.007477 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

HEY1_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.079452 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.082927 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.086502 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.084388 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MLX_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.067215 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.066840 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PER1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.168498 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	215	Shared Neighborhood Hits	21
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.164582 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.171213 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.156428 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.169382 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	479	Shared Neighborhood Hits	23
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER3_MOUSE
θ value	θ > 10 (rank : 59)	NC score	0.187356 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

TCFL5_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.068199 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.073574 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.067353 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.067217 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.059898 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	70	Shared Neighborhood Hits	11
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.059871 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	71	Shared Neighborhood Hits	11
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.057900 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.053961 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

AHR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	47	Target Neighborhood Hits	47	Shared Neighborhood Hits	47
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.993935 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	47	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

SIM2_HUMAN
NC score	0.842738 (rank : 3)	θ value	3.17079e-29 (rank : 3)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.838702 (rank : 4)	θ value	4.57862e-28 (rank : 4)
Query Neighborhood Hits	47	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_HUMAN
NC score	0.835341 (rank : 5)	θ value	1.33217e-27 (rank : 7)
Query Neighborhood Hits	47	Target Neighborhood Hits	62	Shared Neighborhood Hits	33
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.834601 (rank : 6)	θ value	5.97985e-28 (rank : 5)
Query Neighborhood Hits	47	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

HIF1A_MOUSE
NC score	0.830453 (rank : 7)	θ value	7.80994e-28 (rank : 6)
Query Neighborhood Hits	47	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.826852 (rank : 8)	θ value	8.63488e-27 (rank : 8)
Query Neighborhood Hits	47	Target Neighborhood Hits	118	Shared Neighborhood Hits	32
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

NPAS3_MOUSE
NC score	0.817248 (rank : 9)	θ value	2.51237e-26 (rank : 9)
Query Neighborhood Hits	47	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

EPAS1_HUMAN
NC score	0.816161 (rank : 10)	θ value	1.6852e-22 (rank : 12)
Query Neighborhood Hits	47	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.815426 (rank : 11)	θ value	9.87957e-23 (rank : 11)
Query Neighborhood Hits	47	Target Neighborhood Hits	94	Shared Neighborhood Hits	33
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

NPAS3_HUMAN
NC score	0.815377 (rank : 12)	θ value	2.77775e-25 (rank : 10)
Query Neighborhood Hits	47	Target Neighborhood Hits	81	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
NC score	0.805712 (rank : 13)	θ value	2.27762e-19 (rank : 16)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
NC score	0.801844 (rank : 14)	θ value	1.058e-16 (rank : 19)
Query Neighborhood Hits	47	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

CLOCK_HUMAN
NC score	0.753697 (rank : 15)	θ value	1.5773e-20 (rank : 13)
Query Neighborhood Hits	47	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.750577 (rank : 16)	θ value	4.58923e-20 (rank : 14)
Query Neighborhood Hits	47	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

BMAL1_HUMAN
NC score	0.740904 (rank : 17)	θ value	6.62687e-19 (rank : 17)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.740411 (rank : 18)	θ value	1.33526e-19 (rank : 15)
Query Neighborhood Hits	47	Target Neighborhood Hits	121	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

NPAS2_MOUSE
NC score	0.728155 (rank : 19)	θ value	4.74913e-17 (rank : 18)
Query Neighborhood Hits	47	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.721429 (rank : 20)	θ value	1.38178e-16 (rank : 20)
Query Neighborhood Hits	47	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT2_HUMAN
NC score	0.665594 (rank : 21)	θ value	2.52405e-10 (rank : 27)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.663710 (rank : 22)	θ value	5.62301e-10 (rank : 29)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

NPAS4_HUMAN
NC score	0.660700 (rank : 23)	θ value	7.58209e-15 (rank : 21)
Query Neighborhood Hits	47	Target Neighborhood Hits	214	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

ARNT_HUMAN
NC score	0.660566 (rank : 24)	θ value	9.59137e-10 (rank : 30)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	34
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_MOUSE
NC score	0.649385 (rank : 25)	θ value	2.20605e-14 (rank : 22)
Query Neighborhood Hits	47	Target Neighborhood Hits	245	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

ARNT_MOUSE
NC score	0.648789 (rank : 26)	θ value	1.63604e-09 (rank : 31)
Query Neighborhood Hits	47	Target Neighborhood Hits	213	Shared Neighborhood Hits	35
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NCOA1_MOUSE
NC score	0.634284 (rank : 27)	θ value	7.84624e-12 (rank : 25)
Query Neighborhood Hits	47	Target Neighborhood Hits	196	Shared Neighborhood Hits	36
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.632270 (rank : 28)	θ value	7.84624e-12 (rank : 24)
Query Neighborhood Hits	47	Target Neighborhood Hits	198	Shared Neighborhood Hits	36
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.589777 (rank : 29)	θ value	3.52202e-12 (rank : 23)
Query Neighborhood Hits	47	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA2_HUMAN
NC score	0.576231 (rank : 30)	θ value	8.67504e-11 (rank : 26)
Query Neighborhood Hits	47	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
NC score	0.573492 (rank : 31)	θ value	4.30538e-10 (rank : 28)
Query Neighborhood Hits	47	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_MOUSE
NC score	0.551777 (rank : 32)	θ value	4.76016e-09 (rank : 32)
Query Neighborhood Hits	47	Target Neighborhood Hits	203	Shared Neighborhood Hits	32
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.187356 (rank : 33)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	47	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.171213 (rank : 34)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	47	Target Neighborhood Hits	170	Shared Neighborhood Hits	20
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_HUMAN
NC score	0.169382 (rank : 35)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	47	Target Neighborhood Hits	479	Shared Neighborhood Hits	23
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER1_HUMAN
NC score	0.168498 (rank : 36)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	47	Target Neighborhood Hits	215	Shared Neighborhood Hits	21
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.164582 (rank : 37)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	47	Target Neighborhood Hits	235	Shared Neighborhood Hits	20
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_MOUSE
NC score	0.156428 (rank : 38)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	47	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

HES5_MOUSE
NC score	0.105869 (rank : 39)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY2_HUMAN
NC score	0.086502 (rank : 40)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	47	Target Neighborhood Hits	77	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.084388 (rank : 41)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	47	Target Neighborhood Hits	80	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.082927 (rank : 42)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	47	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES3_MOUSE
NC score	0.081527 (rank : 43)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	47	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MITF_HUMAN
NC score	0.080537 (rank : 44)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	47	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.080130 (rank : 45)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	47	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HEY1_HUMAN
NC score	0.079452 (rank : 46)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	47	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

TFE3_HUMAN
NC score	0.073574 (rank : 47)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	47	Target Neighborhood Hits	190	Shared Neighborhood Hits	13
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TCFL5_HUMAN
NC score	0.068199 (rank : 48)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	47	Target Neighborhood Hits	43	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFEB_HUMAN
NC score	0.067353 (rank : 49)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	47	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.067217 (rank : 50)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	47	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MLX_HUMAN
NC score	0.067215 (rank : 51)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	47	Target Neighborhood Hits	95	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.066840 (rank : 52)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	47	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF1_HUMAN
NC score	0.059898 (rank : 53)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	47	Target Neighborhood Hits	70	Shared Neighborhood Hits	11
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.059871 (rank : 54)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	47	Target Neighborhood Hits	71	Shared Neighborhood Hits	11
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.057900 (rank : 55)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	47	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

HES7_HUMAN
NC score	0.054063 (rank : 56)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

USF2_MOUSE
NC score	0.053961 (rank : 57)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	47	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

HES7_MOUSE
NC score	0.052024 (rank : 58)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	47	Target Neighborhood Hits	72	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

RPA1_HUMAN
NC score	0.022382 (rank : 59)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	47	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	O95602, Q9UEH0, Q9UFT9	Gene names	POLR1A
Domain Architecture
Description	DNA-directed RNA polymerase I largest subunit (EC 2.7.7.6) (RNA polymerase I 194 kDa subunit) (RPA194).

R3HD2_MOUSE
NC score	0.016127 (rank : 60)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	47	Target Neighborhood Hits	397	Shared Neighborhood Hits	5
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

OXA1L_MOUSE
NC score	0.009738 (rank : 61)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	47	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGA9, Q8BK01, Q8R091, Q9D8X7	Gene names	Oxa1l
Domain Architecture
Description	Inner membrane protein OXA1L, mitochondrial precursor (Oxidase assembly 1-like protein) (OXA1-like protein).

TJAP1_MOUSE
NC score	0.007477 (rank : 62)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	47	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

PTN22_HUMAN
NC score	0.007401 (rank : 63)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	47	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2R2, O95063, O95064	Gene names	PTPN22, PTPN8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP).

GCC2_MOUSE
NC score	0.002886 (rank : 64)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	47	Target Neighborhood Hits	1619	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

NAF1_MOUSE
NC score	0.001728 (rank : 65)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	47	Target Neighborhood Hits	852	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

ITSN2_MOUSE
NC score	-0.000676 (rank : 66)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	47	Target Neighborhood Hits	1371	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ZBT40_HUMAN
NC score	-0.002082 (rank : 67)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	47	Target Neighborhood Hits	949	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.