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Network neighborhood for query Sequence : HEY2_MOUSE

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HEY2_MOUSE
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HEY2_MOUSE
θ value	5.26011e-125 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
θ value	4.61877e-113 (rank : 2)	NC score	0.996757 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_HUMAN
θ value	1.0458e-56 (rank : 3)	NC score	0.961396 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	6.56568e-51 (rank : 4)	NC score	0.960095 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES1_HUMAN
θ value	5.60996e-18 (rank : 5)	NC score	0.787111 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	5.60996e-18 (rank : 6)	NC score	0.787638 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	78	Shared Neighborhood Hits	35
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES4_HUMAN
θ value	8.10077e-17 (rank : 7)	NC score	0.813024 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_HUMAN
θ value	4.30538e-10 (rank : 8)	NC score	0.720168 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	5.62301e-10 (rank : 9)	NC score	0.724373 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_HUMAN
θ value	9.59137e-10 (rank : 10)	NC score	0.684061 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	4.76016e-09 (rank : 11)	NC score	0.670130 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES5_MOUSE
θ value	5.26297e-08 (rank : 12)	NC score	0.744202 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

BHLH3_MOUSE
θ value	6.87365e-08 (rank : 13)	NC score	0.561823 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
θ value	3.41135e-07 (rank : 14)	NC score	0.558761 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH2_HUMAN
θ value	5.81887e-07 (rank : 15)	NC score	0.535193 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	2.88788e-06 (rank : 16)	NC score	0.525737 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES7_MOUSE
θ value	4.92598e-06 (rank : 17)	NC score	0.584886 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
θ value	1.09739e-05 (rank : 18)	NC score	0.585908 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

BMAL1_HUMAN
θ value	9.29e-05 (rank : 19)	NC score	0.279833 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	9.29e-05 (rank : 20)	NC score	0.283651 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	121	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

HES3_MOUSE
θ value	0.00102713 (rank : 21)	NC score	0.568544 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MLX_HUMAN
θ value	0.00134147 (rank : 22)	NC score	0.315946 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	95	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	0.00134147 (rank : 23)	NC score	0.320280 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

ARNT2_HUMAN
θ value	0.00298849 (rank : 24)	NC score	0.228539 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0.00298849 (rank : 25)	NC score	0.229817 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

USF1_HUMAN
θ value	0.00390308 (rank : 26)	NC score	0.312070 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.00390308 (rank : 27)	NC score	0.311969 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
θ value	0.00509761 (rank : 28)	NC score	0.301537 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
θ value	0.00869519 (rank : 29)	NC score	0.298020 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

ARNT_HUMAN
θ value	0.0113563 (rank : 30)	NC score	0.225281 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0.0113563 (rank : 31)	NC score	0.221920 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

SRBP2_HUMAN
θ value	0.0193708 (rank : 32)	NC score	0.242855 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	133	Shared Neighborhood Hits	38
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFE3_HUMAN
θ value	0.0193708 (rank : 33)	NC score	0.281243 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

SRBP1_HUMAN
θ value	0.0252991 (rank : 34)	NC score	0.241524 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFEB_HUMAN
θ value	0.0431538 (rank : 35)	NC score	0.256768 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	111	Shared Neighborhood Hits	39
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	0.0431538 (rank : 36)	NC score	0.260350 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MITF_HUMAN
θ value	0.0563607 (rank : 37)	NC score	0.269763 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	0.0563607 (rank : 38)	NC score	0.267196 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

SRBP1_MOUSE
θ value	0.125558 (rank : 39)	NC score	0.219028 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	384	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TAL1_HUMAN
θ value	0.125558 (rank : 40)	NC score	0.115563 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	37
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

CLOCK_MOUSE
θ value	0.365318 (rank : 41)	NC score	0.165378 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

LYL1_HUMAN
θ value	0.47712 (rank : 42)	NC score	0.097462 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

CLOCK_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.164215 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

LYL1_MOUSE
θ value	0.62314 (rank : 44)	NC score	0.095328 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	102	Shared Neighborhood Hits	26
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

HNF1A_MOUSE
θ value	0.813845 (rank : 45)	NC score	0.024203 (rank : 110)
Query Neighborhood Hits	80	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

TAL1_MOUSE
θ value	1.06291 (rank : 46)	NC score	0.108774 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	110	Shared Neighborhood Hits	36
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

ALAT1_HUMAN
θ value	1.38821 (rank : 47)	NC score	0.021485 (rank : 112)
Query Neighborhood Hits	80	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P24298, P78398, Q93076	Gene names	GPT, AAT1, GPT1
Domain Architecture
Description	Alanine aminotransferase 1 (EC 2.6.1.2) (ALT1) (Glutamic--pyruvic transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1).

BHLH8_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.083304 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	1.38821 (rank : 49)	NC score	0.082197 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

TAL2_MOUSE
θ value	1.38821 (rank : 50)	NC score	0.089189 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

APLP1_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.023408 (rank : 111)
Query Neighborhood Hits	80	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

ID1_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.075512 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

SIM2_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.113097 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	1.81305 (rank : 54)	NC score	0.111543 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

ELK3_MOUSE
θ value	2.36792 (rank : 55)	NC score	0.015843 (rank : 113)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P41971, P97747, Q62346	Gene names	Elk3, Erp, Net
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP).

ID4_HUMAN
θ value	2.36792 (rank : 56)	NC score	0.071522 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
θ value	2.36792 (rank : 57)	NC score	0.071177 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

NCOA1_HUMAN
θ value	2.36792 (rank : 58)	NC score	0.112560 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	2.36792 (rank : 59)	NC score	0.113081 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NDF4_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.054198 (rank : 102)
Query Neighborhood Hits	80	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

NDF4_MOUSE
θ value	3.0926 (rank : 61)	NC score	0.052024 (rank : 105)
Query Neighborhood Hits	80	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

ALS2_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.011995 (rank : 116)
Query Neighborhood Hits	80	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ELK3_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.014468 (rank : 114)
Query Neighborhood Hits	80	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P41970, Q6FG57, Q6GU29, Q9UD17	Gene names	ELK3, NET, SAP2
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP) (SRF accessory protein 2) (SAP-2).

NPAS3_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.100058 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	4.03905 (rank : 65)	NC score	0.101216 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

SIM1_HUMAN
θ value	4.03905 (rank : 66)	NC score	0.107287 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	4.03905 (rank : 67)	NC score	0.107336 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	69	Shared Neighborhood Hits	21
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

TAL2_HUMAN
θ value	4.03905 (rank : 68)	NC score	0.074721 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	22
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

WDR22_MOUSE
θ value	4.03905 (rank : 69)	NC score	0.012542 (rank : 115)
Query Neighborhood Hits	80	Target Neighborhood Hits	302	Shared Neighborhood Hits	3
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

ID1_HUMAN
θ value	5.27518 (rank : 70)	NC score	0.064752 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

TWST2_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.053393 (rank : 104)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.053462 (rank : 103)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

MAX_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.149410 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	37
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.153696 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

NGN3_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.048495 (rank : 109)
Query Neighborhood Hits	80	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

TFAP4_HUMAN
θ value	6.88961 (rank : 76)	NC score	0.106661 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

TWST1_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.056372 (rank : 95)
Query Neighborhood Hits	80	Target Neighborhood Hits	93	Shared Neighborhood Hits	25
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.056168 (rank : 96)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

GPTC2_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.009024 (rank : 117)
Query Neighborhood Hits	80	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC7, Q8BNJ9, Q8BPM1, Q8CDH9	Gene names	Gpatc2
Domain Architecture
Description	G patch domain-containing protein 2.

HAND1_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.059244 (rank : 88)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	34
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

AHR_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.084388 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.080744 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

EPAS1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.089845 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.090280 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	94	Shared Neighborhood Hits	17
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HAND1_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.055075 (rank : 100)
Query Neighborhood Hits	80	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HEN1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.059760 (rank : 87)
Query Neighborhood Hits	80	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.062678 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.061083 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	26
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.061063 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	26
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HIF1A_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.091866 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.090184 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

MAD1_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.056863 (rank : 94)
Query Neighborhood Hits	80	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.070155 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD3_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.050924 (rank : 108)
Query Neighborhood Hits	80	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAD4_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.083646 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MXI1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.056909 (rank : 93)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.056952 (rank : 92)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCL1_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.062685 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.066365 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCN_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.055631 (rank : 98)
Query Neighborhood Hits	80	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.055286 (rank : 99)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCS_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.062798 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.060798 (rank : 86)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	32
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.056069 (rank : 97)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

NCOA2_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.058354 (rank : 90)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.058610 (rank : 89)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.070662 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	171	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.062359 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS1_HUMAN
θ value	θ > 10 (rank : 109)	NC score	0.081527 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	θ > 10 (rank : 110)	NC score	0.083912 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS2_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.130818 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.129758 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS4_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.057197 (rank : 91)
Query Neighborhood Hits	80	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.054624 (rank : 101)
Query Neighborhood Hits	80	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PER2_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.050982 (rank : 107)
Query Neighborhood Hits	80	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.051488 (rank : 106)
Query Neighborhood Hits	80	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

TCFL5_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.068575 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

Hits sorted by NC score

HEY2_MOUSE
NC score	0.999962 (rank : 1)	θ value	5.26011e-125 (rank : 1)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.996757 (rank : 2)	θ value	4.61877e-113 (rank : 2)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	72
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_HUMAN
NC score	0.961396 (rank : 3)	θ value	1.0458e-56 (rank : 3)
Query Neighborhood Hits	80	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
NC score	0.960095 (rank : 4)	θ value	6.56568e-51 (rank : 4)
Query Neighborhood Hits	80	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES4_HUMAN
NC score	0.813024 (rank : 5)	θ value	8.10077e-17 (rank : 7)
Query Neighborhood Hits	80	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_MOUSE
NC score	0.787638 (rank : 6)	θ value	5.60996e-18 (rank : 6)
Query Neighborhood Hits	80	Target Neighborhood Hits	78	Shared Neighborhood Hits	35
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.787111 (rank : 7)	θ value	5.60996e-18 (rank : 5)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES5_MOUSE
NC score	0.744202 (rank : 8)	θ value	5.26297e-08 (rank : 12)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	30
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES2_MOUSE
NC score	0.724373 (rank : 9)	θ value	5.62301e-10 (rank : 9)
Query Neighborhood Hits	80	Target Neighborhood Hits	36	Shared Neighborhood Hits	23
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.720168 (rank : 10)	θ value	4.30538e-10 (rank : 8)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_HUMAN
NC score	0.684061 (rank : 11)	θ value	9.59137e-10 (rank : 10)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	25
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.670130 (rank : 12)	θ value	4.76016e-09 (rank : 11)
Query Neighborhood Hits	80	Target Neighborhood Hits	49	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_HUMAN
NC score	0.585908 (rank : 13)	θ value	1.09739e-05 (rank : 18)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.584886 (rank : 14)	θ value	4.92598e-06 (rank : 17)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES3_MOUSE
NC score	0.568544 (rank : 15)	θ value	0.00102713 (rank : 21)
Query Neighborhood Hits	80	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH3_MOUSE
NC score	0.561823 (rank : 16)	θ value	6.87365e-08 (rank : 13)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
NC score	0.558761 (rank : 17)	θ value	3.41135e-07 (rank : 14)
Query Neighborhood Hits	80	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH2_HUMAN
NC score	0.535193 (rank : 18)	θ value	5.81887e-07 (rank : 15)
Query Neighborhood Hits	80	Target Neighborhood Hits	80	Shared Neighborhood Hits	41
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.525737 (rank : 19)	θ value	2.88788e-06 (rank : 16)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

MLX_MOUSE
NC score	0.320280 (rank : 20)	θ value	0.00134147 (rank : 23)
Query Neighborhood Hits	80	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.315946 (rank : 21)	θ value	0.00134147 (rank : 22)
Query Neighborhood Hits	80	Target Neighborhood Hits	95	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF1_HUMAN
NC score	0.312070 (rank : 22)	θ value	0.00390308 (rank : 26)
Query Neighborhood Hits	80	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.311969 (rank : 23)	θ value	0.00390308 (rank : 27)
Query Neighborhood Hits	80	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
NC score	0.301537 (rank : 24)	θ value	0.00509761 (rank : 28)
Query Neighborhood Hits	80	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.298020 (rank : 25)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	80	Target Neighborhood Hits	155	Shared Neighborhood Hits	37
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

BMAL1_MOUSE
NC score	0.283651 (rank : 26)	θ value	9.29e-05 (rank : 20)
Query Neighborhood Hits	80	Target Neighborhood Hits	121	Shared Neighborhood Hits	49
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

TFE3_HUMAN
NC score	0.281243 (rank : 27)	θ value	0.0193708 (rank : 33)
Query Neighborhood Hits	80	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

BMAL1_HUMAN
NC score	0.279833 (rank : 28)	θ value	9.29e-05 (rank : 19)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	49
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MITF_HUMAN
NC score	0.269763 (rank : 29)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	80	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.267196 (rank : 30)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.260350 (rank : 31)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	80	Target Neighborhood Hits	119	Shared Neighborhood Hits	39
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.256768 (rank : 32)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	80	Target Neighborhood Hits	111	Shared Neighborhood Hits	39
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

SRBP2_HUMAN
NC score	0.242855 (rank : 33)	θ value	0.0193708 (rank : 32)
Query Neighborhood Hits	80	Target Neighborhood Hits	133	Shared Neighborhood Hits	38
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
NC score	0.241524 (rank : 34)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	80	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ARNT2_MOUSE
NC score	0.229817 (rank : 35)	θ value	0.00298849 (rank : 25)
Query Neighborhood Hits	80	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.228539 (rank : 36)	θ value	0.00298849 (rank : 24)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.225281 (rank : 37)	θ value	0.0113563 (rank : 30)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.221920 (rank : 38)	θ value	0.0113563 (rank : 31)
Query Neighborhood Hits	80	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

SRBP1_MOUSE
NC score	0.219028 (rank : 39)	θ value	0.125558 (rank : 39)
Query Neighborhood Hits	80	Target Neighborhood Hits	384	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

CLOCK_MOUSE
NC score	0.165378 (rank : 40)	θ value	0.365318 (rank : 41)
Query Neighborhood Hits	80	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
NC score	0.164215 (rank : 41)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	80	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MAX_MOUSE
NC score	0.153696 (rank : 42)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	80	Target Neighborhood Hits	139	Shared Neighborhood Hits	37
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.149410 (rank : 43)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	37
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

NPAS2_HUMAN
NC score	0.130818 (rank : 44)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	80	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.129758 (rank : 45)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	80	Target Neighborhood Hits	132	Shared Neighborhood Hits	37
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

TAL1_HUMAN
NC score	0.115563 (rank : 46)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	80	Target Neighborhood Hits	112	Shared Neighborhood Hits	37
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

SIM2_HUMAN
NC score	0.113097 (rank : 47)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

NCOA1_MOUSE
NC score	0.113081 (rank : 48)	θ value	2.36792 (rank : 59)
Query Neighborhood Hits	80	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.112560 (rank : 49)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	80	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

SIM2_MOUSE
NC score	0.111543 (rank : 50)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	80	Target Neighborhood Hits	75	Shared Neighborhood Hits	21
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

TAL1_MOUSE
NC score	0.108774 (rank : 51)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	80	Target Neighborhood Hits	110	Shared Neighborhood Hits	36
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

SIM1_MOUSE
NC score	0.107336 (rank : 52)	θ value	4.03905 (rank : 67)
Query Neighborhood Hits	80	Target Neighborhood Hits	69	Shared Neighborhood Hits	21
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.107287 (rank : 53)	θ value	4.03905 (rank : 66)
Query Neighborhood Hits	80	Target Neighborhood Hits	62	Shared Neighborhood Hits	21
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

TFAP4_HUMAN
NC score	0.106661 (rank : 54)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	80	Target Neighborhood Hits	289	Shared Neighborhood Hits	36
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

NPAS3_MOUSE
NC score	0.101216 (rank : 55)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	80	Target Neighborhood Hits	103	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.100058 (rank : 56)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	80	Target Neighborhood Hits	81	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

LYL1_HUMAN
NC score	0.097462 (rank : 57)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	80	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

LYL1_MOUSE
NC score	0.095328 (rank : 58)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	80	Target Neighborhood Hits	102	Shared Neighborhood Hits	26
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

HIF1A_HUMAN
NC score	0.091866 (rank : 59)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	80	Target Neighborhood Hits	118	Shared Neighborhood Hits	18
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_MOUSE
NC score	0.090280 (rank : 60)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	80	Target Neighborhood Hits	94	Shared Neighborhood Hits	17
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_MOUSE
NC score	0.090184 (rank : 61)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	80	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

EPAS1_HUMAN
NC score	0.089845 (rank : 62)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

TAL2_MOUSE
NC score	0.089189 (rank : 63)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	80	Target Neighborhood Hits	79	Shared Neighborhood Hits	25
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

AHR_HUMAN
NC score	0.084388 (rank : 64)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	80	Target Neighborhood Hits	47	Shared Neighborhood Hits	22
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS1_MOUSE
NC score	0.083912 (rank : 65)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	20
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

MAD4_HUMAN
NC score	0.083646 (rank : 66)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	80	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

BHLH8_HUMAN
NC score	0.083304 (rank : 67)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	80	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
NC score	0.082197 (rank : 68)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NPAS1_HUMAN
NC score	0.081527 (rank : 69)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	18
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_MOUSE
NC score	0.080744 (rank : 70)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	80	Target Neighborhood Hits	55	Shared Neighborhood Hits	18
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

ID1_MOUSE
NC score	0.075512 (rank : 71)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	80	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

TAL2_HUMAN
NC score	0.074721 (rank : 72)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	80	Target Neighborhood Hits	77	Shared Neighborhood Hits	22
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

ID4_HUMAN
NC score	0.071522 (rank : 73)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	80	Target Neighborhood Hits	67	Shared Neighborhood Hits	22
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
NC score	0.071177 (rank : 74)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	80	Target Neighborhood Hits	66	Shared Neighborhood Hits	22
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

NCOA3_HUMAN
NC score	0.070662 (rank : 75)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	80	Target Neighborhood Hits	171	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

MAD1_MOUSE
NC score	0.070155 (rank : 76)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	80	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TCFL5_HUMAN
NC score	0.068575 (rank : 77)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	80	Target Neighborhood Hits	43	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MYCL1_MOUSE
NC score	0.066365 (rank : 78)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	80	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

ID1_HUMAN
NC score	0.064752 (rank : 79)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	80	Target Neighborhood Hits	63	Shared Neighborhood Hits	22
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

MYCS_MOUSE
NC score	0.062798 (rank : 80)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYCL1_HUMAN
NC score	0.062685 (rank : 81)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HEN1_MOUSE
NC score	0.062678 (rank : 82)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	80	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

NCOA3_MOUSE
NC score	0.062359 (rank : 83)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	80	Target Neighborhood Hits	203	Shared Neighborhood Hits	16
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

HEN2_HUMAN
NC score	0.061083 (rank : 84)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	26
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
NC score	0.061063 (rank : 85)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	80	Target Neighborhood Hits	83	Shared Neighborhood Hits	26
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

MYC_HUMAN
NC score	0.060798 (rank : 86)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	80	Target Neighborhood Hits	146	Shared Neighborhood Hits	32
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

HEN1_HUMAN
NC score	0.059760 (rank : 87)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	80	Target Neighborhood Hits	88	Shared Neighborhood Hits	27
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HAND1_MOUSE
NC score	0.059244 (rank : 88)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	34
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

NCOA2_MOUSE
NC score	0.058610 (rank : 89)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.058354 (rank : 90)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	80	Target Neighborhood Hits	281	Shared Neighborhood Hits	16
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS4_HUMAN
NC score	0.057197 (rank : 91)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	80	Target Neighborhood Hits	214	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

MXI1_MOUSE
NC score	0.056952 (rank : 92)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	80	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
NC score	0.056909 (rank : 93)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	80	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD1_HUMAN
NC score	0.056863 (rank : 94)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	80	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TWST1_HUMAN
NC score	0.056372 (rank : 95)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	80	Target Neighborhood Hits	93	Shared Neighborhood Hits	25
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
NC score	0.056168 (rank : 96)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	80	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

MYC_MOUSE
NC score	0.056069 (rank : 97)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_HUMAN
NC score	0.055631 (rank : 98)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	80	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
NC score	0.055286 (rank : 99)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	80	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

HAND1_HUMAN
NC score	0.055075 (rank : 100)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	80	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

NPAS4_MOUSE
NC score	0.054624 (rank : 101)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	80	Target Neighborhood Hits	245	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NDF4_HUMAN
NC score	0.054198 (rank : 102)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	80	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

TWST2_MOUSE
NC score	0.053462 (rank : 103)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.053393 (rank : 104)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	80	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

NDF4_MOUSE
NC score	0.052024 (rank : 105)	θ value	3.0926 (rank : 61)
Query Neighborhood Hits	80	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

PER3_MOUSE
NC score	0.051488 (rank : 106)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	80	Target Neighborhood Hits	85	Shared Neighborhood Hits	13
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.050982 (rank : 107)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	80	Target Neighborhood Hits	170	Shared Neighborhood Hits	12
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

MAD3_HUMAN
NC score	0.050924 (rank : 108)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	80	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

NGN3_MOUSE
NC score	0.048495 (rank : 109)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	80	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

HNF1A_MOUSE
NC score	0.024203 (rank : 110)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	80	Target Neighborhood Hits	212	Shared Neighborhood Hits	4
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

APLP1_MOUSE
NC score	0.023408 (rank : 111)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	80	Target Neighborhood Hits	130	Shared Neighborhood Hits	3
SwissProt Accessions	Q03157, Q8VC38	Gene names	Aplp1
Domain Architecture
Description	Amyloid-like protein 1 precursor (APLP) (APLP-1) [Contains: C30].

ALAT1_HUMAN
NC score	0.021485 (rank : 112)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	80	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P24298, P78398, Q93076	Gene names	GPT, AAT1, GPT1
Domain Architecture
Description	Alanine aminotransferase 1 (EC 2.6.1.2) (ALT1) (Glutamic--pyruvic transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1).

ELK3_MOUSE
NC score	0.015843 (rank : 113)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	80	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P41971, P97747, Q62346	Gene names	Elk3, Erp, Net
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP).

ELK3_HUMAN
NC score	0.014468 (rank : 114)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	80	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	P41970, Q6FG57, Q6GU29, Q9UD17	Gene names	ELK3, NET, SAP2
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP) (SRF accessory protein 2) (SAP-2).

WDR22_MOUSE
NC score	0.012542 (rank : 115)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	80	Target Neighborhood Hits	302	Shared Neighborhood Hits	3
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

ALS2_MOUSE
NC score	0.011995 (rank : 116)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	80	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

GPTC2_MOUSE
NC score	0.009024 (rank : 117)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	80	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	Q7TQC7, Q8BNJ9, Q8BPM1, Q8CDH9	Gene names	Gpatc2
Domain Architecture
Description	G patch domain-containing protein 2.