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Network neighborhood for query Sequence : SRBP2_HUMAN

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SRBP2_HUMAN
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SRBP1_HUMAN
θ value	0 (rank : 1)	NC score	0.905839 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	0 (rank : 2)	NC score	0.882959 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	384	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF1_MOUSE
θ value	4.0297e-08 (rank : 4)	NC score	0.450678 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	48
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
θ value	1.53129e-07 (rank : 5)	NC score	0.447479 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	9.92553e-07 (rank : 6)	NC score	0.426778 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MITF_HUMAN
θ value	1.69304e-06 (rank : 7)	NC score	0.409881 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	113	Shared Neighborhood Hits	54
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

USF2_MOUSE
θ value	1.69304e-06 (rank : 8)	NC score	0.424340 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MITF_MOUSE
θ value	2.88788e-06 (rank : 9)	NC score	0.407274 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
θ value	4.92598e-06 (rank : 10)	NC score	0.415026 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	2.44474e-05 (rank : 11)	NC score	0.386725 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	48
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	2.44474e-05 (rank : 12)	NC score	0.387287 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MYCN_HUMAN
θ value	7.1131e-05 (rank : 13)	NC score	0.290005 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	127	Shared Neighborhood Hits	40
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	9.29e-05 (rank : 14)	NC score	0.289726 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
θ value	0.00020696 (rank : 15)	NC score	0.282593 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAX_HUMAN
θ value	0.000786445 (rank : 16)	NC score	0.381152 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	44
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

CLOCK_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.145088 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	0.00665767 (rank : 18)	NC score	0.146642 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD4_HUMAN
θ value	0.00665767 (rank : 19)	NC score	0.216620 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAX_MOUSE
θ value	0.00665767 (rank : 20)	NC score	0.368871 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

BHLH2_HUMAN
θ value	0.0113563 (rank : 21)	NC score	0.205939 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	45
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

EMSY_MOUSE
θ value	0.0148317 (rank : 22)	NC score	0.069148 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

MYC_HUMAN
θ value	0.0148317 (rank : 23)	NC score	0.269337 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TFAP4_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.263265 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	289	Shared Neighborhood Hits	42
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

BHLH2_MOUSE
θ value	0.0193708 (rank : 25)	NC score	0.202030 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HEY2_HUMAN
θ value	0.0193708 (rank : 26)	NC score	0.239406 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	0.0193708 (rank : 27)	NC score	0.242855 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

ELF1_MOUSE
θ value	0.0330416 (rank : 28)	NC score	0.037412 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

HAND2_HUMAN
θ value	0.0330416 (rank : 29)	NC score	0.130916 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	0.0330416 (rank : 30)	NC score	0.130916 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

SP4_MOUSE
θ value	0.0330416 (rank : 31)	NC score	0.019874 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	759	Shared Neighborhood Hits	18
SwissProt Accessions	Q62445	Gene names	Sp4
Domain Architecture
Description	Transcription factor Sp4.

HEY1_HUMAN
θ value	0.0431538 (rank : 32)	NC score	0.231975 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	0.0431538 (rank : 33)	NC score	0.229242 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MDC1_MOUSE
θ value	0.0431538 (rank : 34)	NC score	0.050034 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	998	Shared Neighborhood Hits	30
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MYCS_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.269453 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYF6_HUMAN
θ value	0.0563607 (rank : 36)	NC score	0.117255 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

SP4_HUMAN
θ value	0.0563607 (rank : 37)	NC score	0.019337 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	749	Shared Neighborhood Hits	16
SwissProt Accessions	Q02446, O60402	Gene names	SP4
Domain Architecture
Description	Transcription factor Sp4 (SPR-1).

HES1_HUMAN
θ value	0.125558 (rank : 38)	NC score	0.187607 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.125558 (rank : 39)	NC score	0.187460 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

R3HD2_MOUSE
θ value	0.125558 (rank : 40)	NC score	0.074696 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

CAH5B_MOUSE
θ value	0.163984 (rank : 41)	NC score	0.023296 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZA0, Q8C3J9, Q8K014	Gene names	Ca5b, Car5b
Domain Architecture
Description	Carbonic anhydrase 5B, mitochondrial precursor (EC 4.2.1.1) (Carbonic anhydrase VB) (Carbonate dehydratase VB) (CA-VB).

MYCL1_MOUSE
θ value	0.163984 (rank : 42)	NC score	0.229297 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SP3_HUMAN
θ value	0.21417 (rank : 43)	NC score	0.018365 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	737	Shared Neighborhood Hits	13
SwissProt Accessions	Q02447, Q8TD56, Q9BQR1	Gene names	SP3
Domain Architecture
Description	Transcription factor Sp3 (SPR-2).

SP3_MOUSE
θ value	0.21417 (rank : 44)	NC score	0.018508 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	731	Shared Neighborhood Hits	12
SwissProt Accessions	O70494, Q68FF2, Q8CF64, Q8K378	Gene names	Sp3
Domain Architecture	No domain graphic available
Description	Transcription factor Sp3.

GP152_HUMAN
θ value	0.279714 (rank : 45)	NC score	0.021288 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	636	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

MYF6_MOUSE
θ value	0.279714 (rank : 46)	NC score	0.106140 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

ATF1_MOUSE
θ value	0.365318 (rank : 47)	NC score	0.043632 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	11
SwissProt Accessions	P81269	Gene names	Atf1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TCR-ATF1).

MXI1_HUMAN
θ value	0.365318 (rank : 48)	NC score	0.174325 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	0.365318 (rank : 49)	NC score	0.179617 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCL1_HUMAN
θ value	0.365318 (rank : 50)	NC score	0.228897 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	146	Shared Neighborhood Hits	47
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

NPAS4_HUMAN
θ value	0.365318 (rank : 51)	NC score	0.058405 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

R3HD1_HUMAN
θ value	0.47712 (rank : 52)	NC score	0.061789 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

MYOG_HUMAN
θ value	0.62314 (rank : 53)	NC score	0.114203 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
θ value	0.62314 (rank : 54)	NC score	0.112906 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

PAPOG_MOUSE
θ value	0.62314 (rank : 55)	NC score	0.025644 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

ARNT_HUMAN
θ value	0.813845 (rank : 56)	NC score	0.139568 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0.813845 (rank : 57)	NC score	0.138344 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	213	Shared Neighborhood Hits	51
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

HAND1_HUMAN
θ value	0.813845 (rank : 58)	NC score	0.097796 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HES4_HUMAN
θ value	0.813845 (rank : 59)	NC score	0.186360 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

BHLH3_HUMAN
θ value	1.06291 (rank : 60)	NC score	0.191465 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	106	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	1.06291 (rank : 61)	NC score	0.192830 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

CK024_MOUSE
θ value	1.06291 (rank : 62)	NC score	0.041982 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	307	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

HES6_MOUSE
θ value	1.06291 (rank : 63)	NC score	0.161138 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

LPP_HUMAN
θ value	1.06291 (rank : 64)	NC score	0.039789 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MDC1_HUMAN
θ value	1.06291 (rank : 65)	NC score	0.047042 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	1446	Shared Neighborhood Hits	42
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

TAL1_HUMAN
θ value	1.06291 (rank : 66)	NC score	0.101428 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

AFF2_HUMAN
θ value	1.38821 (rank : 67)	NC score	0.027438 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

ARNT2_HUMAN
θ value	1.38821 (rank : 68)	NC score	0.124403 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	1.38821 (rank : 69)	NC score	0.125371 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

GP156_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.028979 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

MAD4_MOUSE
θ value	1.38821 (rank : 71)	NC score	0.136532 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

K0319_HUMAN
θ value	1.81305 (rank : 72)	NC score	0.026973 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

MAD1_MOUSE
θ value	1.81305 (rank : 73)	NC score	0.119221 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TITIN_HUMAN
θ value	1.81305 (rank : 74)	NC score	0.004060 (rank : 151)
Query Neighborhood Hits	133	Target Neighborhood Hits	2923	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CEAM7_HUMAN
θ value	2.36792 (rank : 75)	NC score	0.011266 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

HAND1_MOUSE
θ value	2.36792 (rank : 76)	NC score	0.080076 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	29
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

MNT_HUMAN
θ value	2.36792 (rank : 77)	NC score	0.136282 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NPAS4_MOUSE
θ value	2.36792 (rank : 78)	NC score	0.049985 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	245	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PAX3_HUMAN
θ value	2.36792 (rank : 79)	NC score	0.005833 (rank : 148)
Query Neighborhood Hits	133	Target Neighborhood Hits	513	Shared Neighborhood Hits	8
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

PF21B_MOUSE
θ value	2.36792 (rank : 80)	NC score	0.037304 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

RBM25_HUMAN
θ value	2.36792 (rank : 81)	NC score	0.012742 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	682	Shared Neighborhood Hits	10
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

ATF2_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.045968 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	402	Shared Neighborhood Hits	19
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

ATF2_MOUSE
θ value	3.0926 (rank : 83)	NC score	0.045075 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	397	Shared Neighborhood Hits	18
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

CKLF4_HUMAN
θ value	3.0926 (rank : 84)	NC score	0.030223 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZR5, Q8IZR4, Q8IZV1	Gene names	CMTM4, CKLFSF4
Domain Architecture
Description	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4).

CKLF4_MOUSE
θ value	3.0926 (rank : 85)	NC score	0.030315 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ61, Q8K143	Gene names	Cmtm4, Cklfsf4
Domain Architecture
Description	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4).

DCP1A_HUMAN
θ value	3.0926 (rank : 86)	NC score	0.049961 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

LTB1L_HUMAN
θ value	3.0926 (rank : 87)	NC score	0.003487 (rank : 152)
Query Neighborhood Hits	133	Target Neighborhood Hits	553	Shared Neighborhood Hits	5
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MYO15_HUMAN
θ value	3.0926 (rank : 88)	NC score	0.013984 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	671	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO9B_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.007585 (rank : 143)
Query Neighborhood Hits	133	Target Neighborhood Hits	641	Shared Neighborhood Hits	12
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NPAS2_MOUSE
θ value	3.0926 (rank : 90)	NC score	0.083563 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

RTN2_MOUSE
θ value	3.0926 (rank : 91)	NC score	0.018496 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SYM_MOUSE
θ value	3.0926 (rank : 92)	NC score	0.025570 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

ZN292_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.013589 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	918	Shared Neighborhood Hits	11
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

EI2BE_MOUSE
θ value	4.03905 (rank : 94)	NC score	0.019314 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHW4, Q3TU39	Gene names	Eif2b5
Domain Architecture	No domain graphic available
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

K1683_HUMAN
θ value	4.03905 (rank : 95)	NC score	0.037161 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	240	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

NCOA6_MOUSE
θ value	4.03905 (rank : 96)	NC score	0.051912 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	1076	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PPRB_HUMAN
θ value	4.03905 (rank : 97)	NC score	0.020504 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	311	Shared Neighborhood Hits	11
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

RFX5_HUMAN
θ value	4.03905 (rank : 98)	NC score	0.025147 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P48382	Gene names	RFX5
Domain Architecture
Description	DNA-binding protein RFX5 (Regulatory factor X subunit 5).

TA2R7_HUMAN
θ value	4.03905 (rank : 99)	NC score	0.007008 (rank : 145)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYW3	Gene names	TAS2R7
Domain Architecture
Description	Taste receptor type 2 member 7 (T2R7) (Taste receptor family B member 4) (TRB4).

ATF1_HUMAN
θ value	5.27518 (rank : 100)	NC score	0.028596 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P18846, P25168	Gene names	ATF1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TREB36 protein).

HES5_MOUSE
θ value	5.27518 (rank : 101)	NC score	0.114189 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
θ value	5.27518 (rank : 102)	NC score	0.139254 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

MK15_HUMAN
θ value	5.27518 (rank : 103)	NC score	0.000745 (rank : 155)
Query Neighborhood Hits	133	Target Neighborhood Hits	1038	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

NEST_HUMAN
θ value	5.27518 (rank : 104)	NC score	0.005457 (rank : 149)
Query Neighborhood Hits	133	Target Neighborhood Hits	1305	Shared Neighborhood Hits	13
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PDXL2_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.023781 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

T2R41_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.008377 (rank : 142)
Query Neighborhood Hits	133	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	P59532, Q7M704	Gene names	Tas2r41, Tas2r12, Tas2r126, Tas2r26
Domain Architecture	No domain graphic available
Description	Taste receptor type 2 member 41 (T2R41) (T2R12) (T2R26).

TAL1_MOUSE
θ value	5.27518 (rank : 107)	NC score	0.091230 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TARSH_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.034904 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	768	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

WBS14_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.075943 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	273	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

ATX2L_HUMAN
θ value	6.88961 (rank : 110)	NC score	0.030155 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	443	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

B3GA2_HUMAN
θ value	6.88961 (rank : 111)	NC score	0.011245 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPZ5, Q5JS09, Q8TF38, Q96NK4	Gene names	B3GAT2, GLCATS, KIAA1963
Domain Architecture
Description	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (Glucuronosyltransferase-S) (GlcAT-S) (UDP-glucuronosyltransferase-S) (GlcAT-D).

BAZ1B_HUMAN
θ value	6.88961 (rank : 112)	NC score	0.007198 (rank : 144)
Query Neighborhood Hits	133	Target Neighborhood Hits	701	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CAMKV_HUMAN
θ value	6.88961 (rank : 113)	NC score	0.000209 (rank : 156)
Query Neighborhood Hits	133	Target Neighborhood Hits	1084	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CE290_HUMAN
θ value	6.88961 (rank : 114)	NC score	0.001458 (rank : 154)
Query Neighborhood Hits	133	Target Neighborhood Hits	1553	Shared Neighborhood Hits	10
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CIKS_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.033999 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CT075_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.006649 (rank : 147)
Query Neighborhood Hits	133	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

HEN1_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.062634 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
θ value	6.88961 (rank : 118)	NC score	0.062873 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

MAD1_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.112628 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	30
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD3_HUMAN
θ value	6.88961 (rank : 120)	NC score	0.177631 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAGE1_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.026221 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	1389	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

NUDT9_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.013401 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU5, Q3TZ68, Q8K1J4	Gene names	Nudt9
Domain Architecture	No domain graphic available
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

P80C_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.022671 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

CAH5B_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.013518 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2D0	Gene names	CA5B
Domain Architecture
Description	Carbonic anhydrase 5B, mitochondrial precursor (EC 4.2.1.1) (Carbonic anhydrase VB) (Carbonate dehydratase VB) (CA-VB).

FLIP1_MOUSE
θ value	8.99809 (rank : 125)	NC score	0.004978 (rank : 150)
Query Neighborhood Hits	133	Target Neighborhood Hits	1176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

HCFC1_MOUSE
θ value	8.99809 (rank : 126)	NC score	0.019918 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IQEC3_MOUSE
θ value	8.99809 (rank : 127)	NC score	0.009949 (rank : 141)
Query Neighborhood Hits	133	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

NFRKB_MOUSE
θ value	8.99809 (rank : 128)	NC score	0.050510 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	393	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

SYM_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.020410 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

TMM20_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.013861 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q2M3R5, Q86YG5, Q8NBA5	Gene names	TMEM20, C10orf60
Domain Architecture	No domain graphic available
Description	Transmembrane protein 20.

VASN_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.001651 (rank : 153)
Query Neighborhood Hits	133	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

ZEP1_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.019216 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	1036	Shared Neighborhood Hits	19
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

ZHX3_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.006832 (rank : 146)
Query Neighborhood Hits	133	Target Neighborhood Hits	321	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

BHLH8_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.065745 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.066942 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BMAL1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.124102 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.124392 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	121	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CRSP2_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.063905 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

FIGLA_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.067521 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.067719 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	24
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.081172 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.087015 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.071277 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES7_HUMAN
θ value	θ > 10 (rank : 144)	NC score	0.075300 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	θ > 10 (rank : 145)	NC score	0.067252 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD3_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.126033 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MISS_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.050542 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	444	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

MLX_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.211956 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.216353 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	41
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MNT_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.131703 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	432	Shared Neighborhood Hits	50
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCB_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.106965 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

MYCL2_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.137927 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

NPAS2_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.077100 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	34
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

TCFL5_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.060946 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

WBS14_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.052552 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

XBP1_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.064610 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

Hits sorted by NC score

SRBP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	133	Target Neighborhood Hits	133	Shared Neighborhood Hits	133
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
NC score	0.905839 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	133	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.882959 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	133	Target Neighborhood Hits	384	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

USF1_MOUSE
NC score	0.450678 (rank : 4)	θ value	4.0297e-08 (rank : 4)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	48
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.447479 (rank : 5)	θ value	1.53129e-07 (rank : 5)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.426778 (rank : 6)	θ value	9.92553e-07 (rank : 6)
Query Neighborhood Hits	133	Target Neighborhood Hits	155	Shared Neighborhood Hits	52
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.424340 (rank : 7)	θ value	1.69304e-06 (rank : 8)
Query Neighborhood Hits	133	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

TFE3_HUMAN
NC score	0.415026 (rank : 8)	θ value	4.92598e-06 (rank : 10)
Query Neighborhood Hits	133	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_HUMAN
NC score	0.409881 (rank : 9)	θ value	1.69304e-06 (rank : 7)
Query Neighborhood Hits	133	Target Neighborhood Hits	113	Shared Neighborhood Hits	54
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.407274 (rank : 10)	θ value	2.88788e-06 (rank : 9)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	55
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.387287 (rank : 11)	θ value	2.44474e-05 (rank : 12)
Query Neighborhood Hits	133	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.386725 (rank : 12)	θ value	2.44474e-05 (rank : 11)
Query Neighborhood Hits	133	Target Neighborhood Hits	111	Shared Neighborhood Hits	48
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MAX_HUMAN
NC score	0.381152 (rank : 13)	θ value	0.000786445 (rank : 16)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	44
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
NC score	0.368871 (rank : 14)	θ value	0.00665767 (rank : 20)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MYCN_HUMAN
NC score	0.290005 (rank : 15)	θ value	7.1131e-05 (rank : 13)
Query Neighborhood Hits	133	Target Neighborhood Hits	127	Shared Neighborhood Hits	40
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
NC score	0.289726 (rank : 16)	θ value	9.29e-05 (rank : 14)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
NC score	0.282593 (rank : 17)	θ value	0.00020696 (rank : 15)
Query Neighborhood Hits	133	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCS_MOUSE
NC score	0.269453 (rank : 18)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	133	Target Neighborhood Hits	83	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_HUMAN
NC score	0.269337 (rank : 19)	θ value	0.0148317 (rank : 23)
Query Neighborhood Hits	133	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TFAP4_HUMAN
NC score	0.263265 (rank : 20)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	133	Target Neighborhood Hits	289	Shared Neighborhood Hits	42
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

HEY2_MOUSE
NC score	0.242855 (rank : 21)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.239406 (rank : 22)	θ value	0.0193708 (rank : 26)
Query Neighborhood Hits	133	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_HUMAN
NC score	0.231975 (rank : 23)	θ value	0.0431538 (rank : 32)
Query Neighborhood Hits	133	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MYCL1_MOUSE
NC score	0.229297 (rank : 24)	θ value	0.163984 (rank : 42)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HEY1_MOUSE
NC score	0.229242 (rank : 25)	θ value	0.0431538 (rank : 33)
Query Neighborhood Hits	133	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MYCL1_HUMAN
NC score	0.228897 (rank : 26)	θ value	0.365318 (rank : 50)
Query Neighborhood Hits	133	Target Neighborhood Hits	146	Shared Neighborhood Hits	47
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MAD4_HUMAN
NC score	0.216620 (rank : 27)	θ value	0.00665767 (rank : 19)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	37
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MLX_MOUSE
NC score	0.216353 (rank : 28)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	41
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.211956 (rank : 29)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	133	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

BHLH2_HUMAN
NC score	0.205939 (rank : 30)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	133	Target Neighborhood Hits	80	Shared Neighborhood Hits	45
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.202030 (rank : 31)	θ value	0.0193708 (rank : 25)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_MOUSE
NC score	0.192830 (rank : 32)	θ value	1.06291 (rank : 61)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
NC score	0.191465 (rank : 33)	θ value	1.06291 (rank : 60)
Query Neighborhood Hits	133	Target Neighborhood Hits	106	Shared Neighborhood Hits	42
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

HES1_HUMAN
NC score	0.187607 (rank : 34)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.187460 (rank : 35)	θ value	0.125558 (rank : 39)
Query Neighborhood Hits	133	Target Neighborhood Hits	78	Shared Neighborhood Hits	38
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES4_HUMAN
NC score	0.186360 (rank : 36)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	133	Target Neighborhood Hits	58	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MXI1_MOUSE
NC score	0.179617 (rank : 37)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD3_HUMAN
NC score	0.177631 (rank : 38)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	133	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MXI1_HUMAN
NC score	0.174325 (rank : 39)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	133	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

HES6_MOUSE
NC score	0.161138 (rank : 40)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	133	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

CLOCK_MOUSE
NC score	0.146642 (rank : 41)	θ value	0.00665767 (rank : 18)
Query Neighborhood Hits	133	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
NC score	0.145088 (rank : 42)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	133	Target Neighborhood Hits	127	Shared Neighborhood Hits	32
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

ARNT_HUMAN
NC score	0.139568 (rank : 43)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	47
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

HES6_HUMAN
NC score	0.139254 (rank : 44)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	133	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

ARNT_MOUSE
NC score	0.138344 (rank : 45)	θ value	0.813845 (rank : 57)
Query Neighborhood Hits	133	Target Neighborhood Hits	213	Shared Neighborhood Hits	51
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

MYCL2_HUMAN
NC score	0.137927 (rank : 46)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	133	Target Neighborhood Hits	63	Shared Neighborhood Hits	30
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

MAD4_MOUSE
NC score	0.136532 (rank : 47)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	133	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MNT_HUMAN
NC score	0.136282 (rank : 48)	θ value	2.36792 (rank : 77)
Query Neighborhood Hits	133	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
NC score	0.131703 (rank : 49)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	133	Target Neighborhood Hits	432	Shared Neighborhood Hits	50
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HAND2_HUMAN
NC score	0.130916 (rank : 50)	θ value	0.0330416 (rank : 29)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.130916 (rank : 51)	θ value	0.0330416 (rank : 30)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	25
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

MAD3_MOUSE
NC score	0.126033 (rank : 52)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	133	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

ARNT2_MOUSE
NC score	0.125371 (rank : 53)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.124403 (rank : 54)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	133	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

BMAL1_MOUSE
NC score	0.124392 (rank : 55)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	133	Target Neighborhood Hits	121	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.124102 (rank : 56)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	133	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MAD1_MOUSE
NC score	0.119221 (rank : 57)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	32
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYF6_HUMAN
NC score	0.117255 (rank : 58)	θ value	0.0563607 (rank : 36)
Query Neighborhood Hits	133	Target Neighborhood Hits	74	Shared Neighborhood Hits	24
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYOG_HUMAN
NC score	0.114203 (rank : 59)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	133	Target Neighborhood Hits	67	Shared Neighborhood Hits	18
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

HES5_MOUSE
NC score	0.114189 (rank : 60)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MYOG_MOUSE
NC score	0.112906 (rank : 61)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	133	Target Neighborhood Hits	71	Shared Neighborhood Hits	18
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

MAD1_HUMAN
NC score	0.112628 (rank : 62)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	133	Target Neighborhood Hits	68	Shared Neighborhood Hits	30
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYCB_MOUSE
NC score	0.106965 (rank : 63)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	133	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

MYF6_MOUSE
NC score	0.106140 (rank : 64)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

TAL1_HUMAN
NC score	0.101428 (rank : 65)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	133	Target Neighborhood Hits	112	Shared Neighborhood Hits	28
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

HAND1_HUMAN
NC score	0.097796 (rank : 66)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	27
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

TAL1_MOUSE
NC score	0.091230 (rank : 67)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	133	Target Neighborhood Hits	110	Shared Neighborhood Hits	28
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

HES2_MOUSE
NC score	0.087015 (rank : 68)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

NPAS2_MOUSE
NC score	0.083563 (rank : 69)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	133	Target Neighborhood Hits	132	Shared Neighborhood Hits	33
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

HES2_HUMAN
NC score	0.081172 (rank : 70)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HAND1_MOUSE
NC score	0.080076 (rank : 71)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	29
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

NPAS2_HUMAN
NC score	0.077100 (rank : 72)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	133	Target Neighborhood Hits	150	Shared Neighborhood Hits	34
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

WBS14_HUMAN
NC score	0.075943 (rank : 73)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	133	Target Neighborhood Hits	273	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HES7_HUMAN
NC score	0.075300 (rank : 74)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

R3HD2_MOUSE
NC score	0.074696 (rank : 75)	θ value	0.125558 (rank : 40)
Query Neighborhood Hits	133	Target Neighborhood Hits	397	Shared Neighborhood Hits	15
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

HES3_MOUSE
NC score	0.071277 (rank : 76)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	133	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

EMSY_MOUSE
NC score	0.069148 (rank : 77)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	133	Target Neighborhood Hits	294	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

FIGLA_MOUSE
NC score	0.067719 (rank : 78)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	133	Target Neighborhood Hits	100	Shared Neighborhood Hits	24
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_HUMAN
NC score	0.067521 (rank : 79)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	133	Target Neighborhood Hits	108	Shared Neighborhood Hits	26
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES7_MOUSE
NC score	0.067252 (rank : 80)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	133	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

BHLH8_MOUSE
NC score	0.066942 (rank : 81)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	133	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_HUMAN
NC score	0.065745 (rank : 82)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	133	Target Neighborhood Hits	123	Shared Neighborhood Hits	32
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

XBP1_MOUSE
NC score	0.064610 (rank : 83)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	133	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

CRSP2_HUMAN
NC score	0.063905 (rank : 84)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	133	Target Neighborhood Hits	380	Shared Neighborhood Hits	13
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

HEN1_MOUSE
NC score	0.062873 (rank : 85)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	133	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_HUMAN
NC score	0.062634 (rank : 86)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	133	Target Neighborhood Hits	88	Shared Neighborhood Hits	11
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

R3HD1_HUMAN
NC score	0.061789 (rank : 87)	θ value	0.47712 (rank : 52)
Query Neighborhood Hits	133	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	Q15032, Q8IW32	Gene names	R3HDM1, KIAA0029, R3HDM
Domain Architecture	No domain graphic available
Description	R3H domain-containing protein 1.

TCFL5_HUMAN
NC score	0.060946 (rank : 88)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

NPAS4_HUMAN
NC score	0.058405 (rank : 89)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	133	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

WBS14_MOUSE
NC score	0.052552 (rank : 90)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	133	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

NCOA6_MOUSE
NC score	0.051912 (rank : 91)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	133	Target Neighborhood Hits	1076	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

MISS_MOUSE
NC score	0.050542 (rank : 92)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	133	Target Neighborhood Hits	444	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

NFRKB_MOUSE
NC score	0.050510 (rank : 93)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	133	Target Neighborhood Hits	393	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

MDC1_MOUSE
NC score	0.050034 (rank : 94)	θ value	0.0431538 (rank : 34)
Query Neighborhood Hits	133	Target Neighborhood Hits	998	Shared Neighborhood Hits	30
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NPAS4_MOUSE
NC score	0.049985 (rank : 95)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	133	Target Neighborhood Hits	245	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

DCP1A_HUMAN
NC score	0.049961 (rank : 96)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	133	Target Neighborhood Hits	228	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

MDC1_HUMAN
NC score	0.047042 (rank : 97)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	133	Target Neighborhood Hits	1446	Shared Neighborhood Hits	42
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

ATF2_HUMAN
NC score	0.045968 (rank : 98)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	133	Target Neighborhood Hits	402	Shared Neighborhood Hits	19
SwissProt Accessions	P15336, Q13000	Gene names	ATF2, CREB2, CREBP1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (HB16).

ATF2_MOUSE
NC score	0.045075 (rank : 99)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	133	Target Neighborhood Hits	397	Shared Neighborhood Hits	18
SwissProt Accessions	P16951, Q64089, Q64090, Q64091	Gene names	Atf2
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-2 (Activating transcription factor 2) (cAMP response element-binding protein CRE- BP1) (MXBP protein).

ATF1_MOUSE
NC score	0.043632 (rank : 100)	θ value	0.365318 (rank : 47)
Query Neighborhood Hits	133	Target Neighborhood Hits	70	Shared Neighborhood Hits	11
SwissProt Accessions	P81269	Gene names	Atf1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TCR-ATF1).

CK024_MOUSE
NC score	0.041982 (rank : 101)	θ value	1.06291 (rank : 62)
Query Neighborhood Hits	133	Target Neighborhood Hits	307	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

LPP_HUMAN
NC score	0.039789 (rank : 102)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	133	Target Neighborhood Hits	775	Shared Neighborhood Hits	17
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

ELF1_MOUSE
NC score	0.037412 (rank : 103)	θ value	0.0330416 (rank : 28)
Query Neighborhood Hits	133	Target Neighborhood Hits	139	Shared Neighborhood Hits	10
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

PF21B_MOUSE
NC score	0.037304 (rank : 104)	θ value	2.36792 (rank : 80)
Query Neighborhood Hits	133	Target Neighborhood Hits	278	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

K1683_HUMAN
NC score	0.037161 (rank : 105)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	133	Target Neighborhood Hits	240	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

TARSH_HUMAN
NC score	0.034904 (rank : 106)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	133	Target Neighborhood Hits	768	Shared Neighborhood Hits	23
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

CIKS_HUMAN
NC score	0.033999 (rank : 107)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	133	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	O43734, Q5R3A3, Q9H5W2, Q9H6Y3, Q9NS14, Q9UG72	Gene names	TRAF3IP2, C6orf4, C6orf5
Domain Architecture	No domain graphic available
Description	Adapter protein CIKS (Connection to IKK and SAPK/JNK) (TRAF3- interacting protein 2) (Nuclear factor NF-kappa-B activator 1) (ACT1).

CKLF4_MOUSE
NC score	0.030315 (rank : 108)	θ value	3.0926 (rank : 85)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ61, Q8K143	Gene names	Cmtm4, Cklfsf4
Domain Architecture
Description	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4).

CKLF4_HUMAN
NC score	0.030223 (rank : 109)	θ value	3.0926 (rank : 84)
Query Neighborhood Hits	133	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IZR5, Q8IZR4, Q8IZV1	Gene names	CMTM4, CKLFSF4
Domain Architecture
Description	CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4).

ATX2L_HUMAN
NC score	0.030155 (rank : 110)	θ value	6.88961 (rank : 110)
Query Neighborhood Hits	133	Target Neighborhood Hits	443	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

GP156_HUMAN
NC score	0.028979 (rank : 111)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	133	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFN8, Q86SN6	Gene names	GPR156, GABABL, PGR28
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor) (G-protein coupled receptor PGR28).

ATF1_HUMAN
NC score	0.028596 (rank : 112)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P18846, P25168	Gene names	ATF1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-1 (Activating transcription factor 1) (TREB36 protein).

AFF2_HUMAN
NC score	0.027438 (rank : 113)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	133	Target Neighborhood Hits	218	Shared Neighborhood Hits	11
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

K0319_HUMAN
NC score	0.026973 (rank : 114)	θ value	1.81305 (rank : 72)
Query Neighborhood Hits	133	Target Neighborhood Hits	154	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

MAGE1_HUMAN
NC score	0.026221 (rank : 115)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	133	Target Neighborhood Hits	1389	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PAPOG_MOUSE
NC score	0.025644 (rank : 116)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	133	Target Neighborhood Hits	103	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PCL9, Q8BZC9	Gene names	Papolg
Domain Architecture	No domain graphic available
Description	Poly(A) polymerase gamma (EC 2.7.7.19) (PAP gamma) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3' adenylating enzyme).

SYM_MOUSE
NC score	0.025570 (rank : 117)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	133	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

RFX5_HUMAN
NC score	0.025147 (rank : 118)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	133	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P48382	Gene names	RFX5
Domain Architecture
Description	DNA-binding protein RFX5 (Regulatory factor X subunit 5).

PDXL2_MOUSE
NC score	0.023781 (rank : 119)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	133	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

CAH5B_MOUSE
NC score	0.023296 (rank : 120)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	133	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QZA0, Q8C3J9, Q8K014	Gene names	Ca5b, Car5b
Domain Architecture
Description	Carbonic anhydrase 5B, mitochondrial precursor (EC 4.2.1.1) (Carbonic anhydrase VB) (Carbonate dehydratase VB) (CA-VB).

P80C_HUMAN
NC score	0.022671 (rank : 121)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	133	Target Neighborhood Hits	73	Shared Neighborhood Hits	3
SwissProt Accessions	P38432	Gene names	COIL, CLN80
Domain Architecture	No domain graphic available
Description	Coilin (p80).

GP152_HUMAN
NC score	0.021288 (rank : 122)	θ value	0.279714 (rank : 45)
Query Neighborhood Hits	133	Target Neighborhood Hits	636	Shared Neighborhood Hits	15
SwissProt Accessions	Q8TDT2, Q86SM0	Gene names	GPR152, PGR5
Domain Architecture
Description	Probable G-protein coupled receptor 152 (G-protein coupled receptor PGR5).

PPRB_HUMAN
NC score	0.020504 (rank : 123)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	133	Target Neighborhood Hits	311	Shared Neighborhood Hits	11
SwissProt Accessions	Q15648, O43810, O75447, Q9HD39	Gene names	PPARBP, ARC205, DRIP205, TRAP220, TRIP2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2) (p53 regulatory protein RB18A) (Vitamin D receptor-interacting protein complex component DRIP205) (Activator- recruited cofactor 205 kDa component) (ARC205).

SYM_HUMAN
NC score	0.020410 (rank : 124)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	133	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

HCFC1_MOUSE
NC score	0.019918 (rank : 125)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	133	Target Neighborhood Hits	348	Shared Neighborhood Hits	17
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

SP4_MOUSE
NC score	0.019874 (rank : 126)	θ value	0.0330416 (rank : 31)
Query Neighborhood Hits	133	Target Neighborhood Hits	759	Shared Neighborhood Hits	18
SwissProt Accessions	Q62445	Gene names	Sp4
Domain Architecture
Description	Transcription factor Sp4.

SP4_HUMAN
NC score	0.019337 (rank : 127)	θ value	0.0563607 (rank : 37)
Query Neighborhood Hits	133	Target Neighborhood Hits	749	Shared Neighborhood Hits	16
SwissProt Accessions	Q02446, O60402	Gene names	SP4
Domain Architecture
Description	Transcription factor Sp4 (SPR-1).

EI2BE_MOUSE
NC score	0.019314 (rank : 128)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	133	Target Neighborhood Hits	30	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CHW4, Q3TU39	Gene names	Eif2b5
Domain Architecture	No domain graphic available
Description	Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon).

ZEP1_HUMAN
NC score	0.019216 (rank : 129)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	133	Target Neighborhood Hits	1036	Shared Neighborhood Hits	19
SwissProt Accessions	P15822, Q14122	Gene names	HIVEP1, ZNF40
Domain Architecture	No domain graphic available
Description	Zinc finger protein 40 (Human immunodeficiency virus type I enhancer- binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1).

SP3_MOUSE
NC score	0.018508 (rank : 130)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	133	Target Neighborhood Hits	731	Shared Neighborhood Hits	12
SwissProt Accessions	O70494, Q68FF2, Q8CF64, Q8K378	Gene names	Sp3
Domain Architecture	No domain graphic available
Description	Transcription factor Sp3.

RTN2_MOUSE
NC score	0.018496 (rank : 131)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	133	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SP3_HUMAN
NC score	0.018365 (rank : 132)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	133	Target Neighborhood Hits	737	Shared Neighborhood Hits	13
SwissProt Accessions	Q02447, Q8TD56, Q9BQR1	Gene names	SP3
Domain Architecture
Description	Transcription factor Sp3 (SPR-2).

MYO15_HUMAN
NC score	0.013984 (rank : 133)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	133	Target Neighborhood Hits	671	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

TMM20_HUMAN
NC score	0.013861 (rank : 134)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	133	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q2M3R5, Q86YG5, Q8NBA5	Gene names	TMEM20, C10orf60
Domain Architecture	No domain graphic available
Description	Transmembrane protein 20.

ZN292_HUMAN
NC score	0.013589 (rank : 135)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	133	Target Neighborhood Hits	918	Shared Neighborhood Hits	11
SwissProt Accessions	O60281, Q9H8G3, Q9H8J4	Gene names	ZNF292, KIAA0530
Domain Architecture	No domain graphic available
Description	Zinc finger protein 292.

CAH5B_HUMAN
NC score	0.013518 (rank : 136)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	133	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2D0	Gene names	CA5B
Domain Architecture
Description	Carbonic anhydrase 5B, mitochondrial precursor (EC 4.2.1.1) (Carbonic anhydrase VB) (Carbonate dehydratase VB) (CA-VB).

NUDT9_MOUSE
NC score	0.013401 (rank : 137)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	133	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BVU5, Q3TZ68, Q8K1J4	Gene names	Nudt9
Domain Architecture	No domain graphic available
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

RBM25_HUMAN
NC score	0.012742 (rank : 138)	θ value	2.36792 (rank : 81)
Query Neighborhood Hits	133	Target Neighborhood Hits	682	Shared Neighborhood Hits	10
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

CEAM7_HUMAN
NC score	0.011266 (rank : 139)	θ value	2.36792 (rank : 75)
Query Neighborhood Hits	133	Target Neighborhood Hits	170	Shared Neighborhood Hits	3
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

B3GA2_HUMAN
NC score	0.011245 (rank : 140)	θ value	6.88961 (rank : 111)
Query Neighborhood Hits	133	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPZ5, Q5JS09, Q8TF38, Q96NK4	Gene names	B3GAT2, GLCATS, KIAA1963
Domain Architecture
Description	Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 (EC 2.4.1.135) (Beta-1,3-glucuronyltransferase 2) (Glucuronosyltransferase-S) (GlcAT-S) (UDP-glucuronosyltransferase-S) (GlcAT-D).

IQEC3_MOUSE
NC score	0.009949 (rank : 141)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	133	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

T2R41_MOUSE
NC score	0.008377 (rank : 142)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	133	Target Neighborhood Hits	79	Shared Neighborhood Hits	3
SwissProt Accessions	P59532, Q7M704	Gene names	Tas2r41, Tas2r12, Tas2r126, Tas2r26
Domain Architecture	No domain graphic available
Description	Taste receptor type 2 member 41 (T2R41) (T2R12) (T2R26).

MYO9B_HUMAN
NC score	0.007585 (rank : 143)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	133	Target Neighborhood Hits	641	Shared Neighborhood Hits	12
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

BAZ1B_HUMAN
NC score	0.007198 (rank : 144)	θ value	6.88961 (rank : 112)
Query Neighborhood Hits	133	Target Neighborhood Hits	701	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

TA2R7_HUMAN
NC score	0.007008 (rank : 145)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	133	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYW3	Gene names	TAS2R7
Domain Architecture
Description	Taste receptor type 2 member 7 (T2R7) (Taste receptor family B member 4) (TRB4).

ZHX3_MOUSE
NC score	0.006832 (rank : 146)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	133	Target Neighborhood Hits	321	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

CT075_MOUSE
NC score	0.006649 (rank : 147)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	133	Target Neighborhood Hits	358	Shared Neighborhood Hits	6
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

PAX3_HUMAN
NC score	0.005833 (rank : 148)	θ value	2.36792 (rank : 79)
Query Neighborhood Hits	133	Target Neighborhood Hits	513	Shared Neighborhood Hits	8
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

NEST_HUMAN
NC score	0.005457 (rank : 149)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	133	Target Neighborhood Hits	1305	Shared Neighborhood Hits	13
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

FLIP1_MOUSE
NC score	0.004978 (rank : 150)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	133	Target Neighborhood Hits	1176	Shared Neighborhood Hits	15
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

TITIN_HUMAN
NC score	0.004060 (rank : 151)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	133	Target Neighborhood Hits	2923	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

LTB1L_HUMAN
NC score	0.003487 (rank : 152)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	133	Target Neighborhood Hits	553	Shared Neighborhood Hits	5
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

VASN_MOUSE
NC score	0.001651 (rank : 153)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	133	Target Neighborhood Hits	426	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CZT5, Q8BJJ0, Q8R2G5	Gene names	Vasn, Slitl2
Domain Architecture	No domain graphic available
Description	Vasorin precursor (Protein Slit-like 2).

CE290_HUMAN
NC score	0.001458 (rank : 154)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	133	Target Neighborhood Hits	1553	Shared Neighborhood Hits	10
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

MK15_HUMAN
NC score	0.000745 (rank : 155)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	133	Target Neighborhood Hits	1038	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

CAMKV_HUMAN
NC score	0.000209 (rank : 156)	θ value	6.88961 (rank : 113)
Query Neighborhood Hits	133	Target Neighborhood Hits	1084	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.