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Network neighborhood for query Sequence : HES5_MOUSE

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HES5_MOUSE
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES5_MOUSE
θ value	6.11685e-65 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	38
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES1_HUMAN
θ value	1.74796e-11 (rank : 2)	NC score	0.821421 (rank : 6)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	1.74796e-11 (rank : 3)	NC score	0.821829 (rank : 5)
Query Neighborhood Hits	38	Target Neighborhood Hits	78	Shared Neighborhood Hits	26
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES7_MOUSE
θ value	8.67504e-11 (rank : 4)	NC score	0.772129 (rank : 8)
Query Neighborhood Hits	38	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
θ value	3.29651e-10 (rank : 5)	NC score	0.772983 (rank : 7)
Query Neighborhood Hits	38	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES4_HUMAN
θ value	4.30538e-10 (rank : 6)	NC score	0.849466 (rank : 2)
Query Neighborhood Hits	38	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HEY1_HUMAN
θ value	1.25267e-09 (rank : 7)	NC score	0.750373 (rank : 10)
Query Neighborhood Hits	38	Target Neighborhood Hits	82	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	1.25267e-09 (rank : 8)	NC score	0.753503 (rank : 9)
Query Neighborhood Hits	38	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES2_HUMAN
θ value	2.79066e-09 (rank : 9)	NC score	0.826413 (rank : 4)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	6.21693e-09 (rank : 10)	NC score	0.831350 (rank : 3)
Query Neighborhood Hits	38	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HEY2_HUMAN
θ value	2.36244e-08 (rank : 11)	NC score	0.745967 (rank : 12)
Query Neighborhood Hits	38	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	5.26297e-08 (rank : 12)	NC score	0.744202 (rank : 13)
Query Neighborhood Hits	38	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES3_MOUSE
θ value	8.97725e-08 (rank : 13)	NC score	0.749049 (rank : 11)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES6_HUMAN
θ value	3.77169e-06 (rank : 14)	NC score	0.722615 (rank : 14)
Query Neighborhood Hits	38	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	3.77169e-06 (rank : 15)	NC score	0.714157 (rank : 15)
Query Neighborhood Hits	38	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

BHLH3_HUMAN
θ value	8.40245e-06 (rank : 16)	NC score	0.575593 (rank : 16)
Query Neighborhood Hits	38	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	1.09739e-05 (rank : 17)	NC score	0.574536 (rank : 17)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_MOUSE
θ value	0.00035302 (rank : 18)	NC score	0.548708 (rank : 19)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH2_HUMAN
θ value	0.000461057 (rank : 19)	NC score	0.560765 (rank : 18)
Query Neighborhood Hits	38	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

AHR_MOUSE
θ value	0.21417 (rank : 20)	NC score	0.107679 (rank : 31)
Query Neighborhood Hits	38	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.169443 (rank : 21)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.47712 (rank : 22)	NC score	0.172604 (rank : 20)
Query Neighborhood Hits	38	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.121847 (rank : 27)
Query Neighborhood Hits	38	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

AHR_HUMAN
θ value	1.06291 (rank : 24)	NC score	0.105869 (rank : 35)
Query Neighborhood Hits	38	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CLOCK_MOUSE
θ value	1.06291 (rank : 25)	NC score	0.117486 (rank : 29)
Query Neighborhood Hits	38	Target Neighborhood Hits	148	Shared Neighborhood Hits	23
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

USF2_MOUSE
θ value	2.36792 (rank : 26)	NC score	0.129244 (rank : 24)
Query Neighborhood Hits	38	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF1_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.140174 (rank : 22)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.140169 (rank : 23)
Query Neighborhood Hits	38	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

EPAS1_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.065676 (rank : 53)
Query Neighborhood Hits	38	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

SRBP2_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.114189 (rank : 30)
Query Neighborhood Hits	38	Target Neighborhood Hits	133	Shared Neighborhood Hits	21
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MAP1A_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.008666 (rank : 62)
Query Neighborhood Hits	38	Target Neighborhood Hits	1626	Shared Neighborhood Hits	5
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NPAS2_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.106422 (rank : 33)
Query Neighborhood Hits	38	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.106550 (rank : 32)
Query Neighborhood Hits	38	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

SIM2_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.073616 (rank : 46)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

LYST_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.008449 (rank : 63)
Query Neighborhood Hits	38	Target Neighborhood Hits	324	Shared Neighborhood Hits	2
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MILK1_MOUSE
θ value	8.99809 (rank : 36)	NC score	0.005798 (rank : 64)
Query Neighborhood Hits	38	Target Neighborhood Hits	788	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SIM1_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.070755 (rank : 48)
Query Neighborhood Hits	38	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.070877 (rank : 47)
Query Neighborhood Hits	38	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

ARNT2_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.093902 (rank : 40)
Query Neighborhood Hits	38	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	θ > 10 (rank : 40)	NC score	0.095276 (rank : 39)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.092928 (rank : 41)
Query Neighborhood Hits	38	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.092254 (rank : 42)
Query Neighborhood Hits	38	Target Neighborhood Hits	213	Shared Neighborhood Hits	25
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

EPAS1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.061536 (rank : 56)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

HIF1A_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.064582 (rank : 54)
Query Neighborhood Hits	38	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.062725 (rank : 55)
Query Neighborhood Hits	38	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

MAD1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.051111 (rank : 61)
Query Neighborhood Hits	38	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.066073 (rank : 52)
Query Neighborhood Hits	38	Target Neighborhood Hits	75	Shared Neighborhood Hits	14
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MITF_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.103555 (rank : 36)
Query Neighborhood Hits	38	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.099599 (rank : 38)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.123943 (rank : 25)
Query Neighborhood Hits	38	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 51)	NC score	0.123772 (rank : 26)
Query Neighborhood Hits	38	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

NCOA1_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.068503 (rank : 51)
Query Neighborhood Hits	38	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	θ > 10 (rank : 53)	NC score	0.068851 (rank : 50)
Query Neighborhood Hits	38	Target Neighborhood Hits	196	Shared Neighborhood Hits	22
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NPAS1_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.052870 (rank : 59)
Query Neighborhood Hits	38	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	θ > 10 (rank : 55)	NC score	0.052823 (rank : 60)
Query Neighborhood Hits	38	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.061048 (rank : 58)
Query Neighborhood Hits	38	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	θ > 10 (rank : 57)	NC score	0.061246 (rank : 57)
Query Neighborhood Hits	38	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

SIM2_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.069140 (rank : 49)
Query Neighborhood Hits	38	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SRBP1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.100162 (rank : 37)
Query Neighborhood Hits	38	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.090193 (rank : 43)
Query Neighborhood Hits	38	Target Neighborhood Hits	384	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFE3_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.105941 (rank : 34)
Query Neighborhood Hits	38	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.083392 (rank : 45)
Query Neighborhood Hits	38	Target Neighborhood Hits	111	Shared Neighborhood Hits	23
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.084680 (rank : 44)
Query Neighborhood Hits	38	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.117727 (rank : 28)
Query Neighborhood Hits	38	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

Hits sorted by NC score

HES5_MOUSE
NC score	0.999962 (rank : 1)	θ value	6.11685e-65 (rank : 1)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	38
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES4_HUMAN
NC score	0.849466 (rank : 2)	θ value	4.30538e-10 (rank : 6)
Query Neighborhood Hits	38	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_MOUSE
NC score	0.831350 (rank : 3)	θ value	6.21693e-09 (rank : 10)
Query Neighborhood Hits	38	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.826413 (rank : 4)	θ value	2.79066e-09 (rank : 9)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES1_MOUSE
NC score	0.821829 (rank : 5)	θ value	1.74796e-11 (rank : 3)
Query Neighborhood Hits	38	Target Neighborhood Hits	78	Shared Neighborhood Hits	26
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.821421 (rank : 6)	θ value	1.74796e-11 (rank : 2)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES7_HUMAN
NC score	0.772983 (rank : 7)	θ value	3.29651e-10 (rank : 5)
Query Neighborhood Hits	38	Target Neighborhood Hits	72	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.772129 (rank : 8)	θ value	8.67504e-11 (rank : 4)
Query Neighborhood Hits	38	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HEY1_MOUSE
NC score	0.753503 (rank : 9)	θ value	1.25267e-09 (rank : 8)
Query Neighborhood Hits	38	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.750373 (rank : 10)	θ value	1.25267e-09 (rank : 7)
Query Neighborhood Hits	38	Target Neighborhood Hits	82	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES3_MOUSE
NC score	0.749049 (rank : 11)	θ value	8.97725e-08 (rank : 13)
Query Neighborhood Hits	38	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HEY2_HUMAN
NC score	0.745967 (rank : 12)	θ value	2.36244e-08 (rank : 11)
Query Neighborhood Hits	38	Target Neighborhood Hits	77	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.744202 (rank : 13)	θ value	5.26297e-08 (rank : 12)
Query Neighborhood Hits	38	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES6_HUMAN
NC score	0.722615 (rank : 14)	θ value	3.77169e-06 (rank : 14)
Query Neighborhood Hits	38	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.714157 (rank : 15)	θ value	3.77169e-06 (rank : 15)
Query Neighborhood Hits	38	Target Neighborhood Hits	49	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

BHLH3_HUMAN
NC score	0.575593 (rank : 16)	θ value	8.40245e-06 (rank : 16)
Query Neighborhood Hits	38	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.574536 (rank : 17)	θ value	1.09739e-05 (rank : 17)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_HUMAN
NC score	0.560765 (rank : 18)	θ value	0.000461057 (rank : 19)
Query Neighborhood Hits	38	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.548708 (rank : 19)	θ value	0.00035302 (rank : 18)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BMAL1_MOUSE
NC score	0.172604 (rank : 20)	θ value	0.47712 (rank : 22)
Query Neighborhood Hits	38	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.169443 (rank : 21)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

USF1_HUMAN
NC score	0.140174 (rank : 22)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	38	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.140169 (rank : 23)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	38	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_MOUSE
NC score	0.129244 (rank : 24)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	38	Target Neighborhood Hits	173	Shared Neighborhood Hits	20
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MLX_HUMAN
NC score	0.123943 (rank : 25)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	38	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.123772 (rank : 26)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	38	Target Neighborhood Hits	100	Shared Neighborhood Hits	17
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

CLOCK_HUMAN
NC score	0.121847 (rank : 27)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	38	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

USF2_HUMAN
NC score	0.117727 (rank : 28)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	38	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

CLOCK_MOUSE
NC score	0.117486 (rank : 29)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	38	Target Neighborhood Hits	148	Shared Neighborhood Hits	23
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

SRBP2_HUMAN
NC score	0.114189 (rank : 30)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	38	Target Neighborhood Hits	133	Shared Neighborhood Hits	21
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

AHR_MOUSE
NC score	0.107679 (rank : 31)	θ value	0.21417 (rank : 20)
Query Neighborhood Hits	38	Target Neighborhood Hits	55	Shared Neighborhood Hits	14
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS2_MOUSE
NC score	0.106550 (rank : 32)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	38	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.106422 (rank : 33)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	38	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

TFE3_HUMAN
NC score	0.105941 (rank : 34)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	38	Target Neighborhood Hits	190	Shared Neighborhood Hits	22
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

AHR_HUMAN
NC score	0.105869 (rank : 35)	θ value	1.06291 (rank : 24)
Query Neighborhood Hits	38	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

MITF_HUMAN
NC score	0.103555 (rank : 36)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	38	Target Neighborhood Hits	113	Shared Neighborhood Hits	25
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

SRBP1_HUMAN
NC score	0.100162 (rank : 37)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	38	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MITF_MOUSE
NC score	0.099599 (rank : 38)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

ARNT2_MOUSE
NC score	0.095276 (rank : 39)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	38	Target Neighborhood Hits	115	Shared Neighborhood Hits	25
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.093902 (rank : 40)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	38	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.092928 (rank : 41)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	38	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.092254 (rank : 42)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	38	Target Neighborhood Hits	213	Shared Neighborhood Hits	25
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

SRBP1_MOUSE
NC score	0.090193 (rank : 43)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	38	Target Neighborhood Hits	384	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFEB_MOUSE
NC score	0.084680 (rank : 44)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	38	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.083392 (rank : 45)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	38	Target Neighborhood Hits	111	Shared Neighborhood Hits	23
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

SIM2_HUMAN
NC score	0.073616 (rank : 46)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM1_MOUSE
NC score	0.070877 (rank : 47)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	38	Target Neighborhood Hits	69	Shared Neighborhood Hits	17
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.070755 (rank : 48)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	38	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM2_MOUSE
NC score	0.069140 (rank : 49)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	38	Target Neighborhood Hits	75	Shared Neighborhood Hits	16
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NCOA1_MOUSE
NC score	0.068851 (rank : 50)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	38	Target Neighborhood Hits	196	Shared Neighborhood Hits	22
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.068503 (rank : 51)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	38	Target Neighborhood Hits	198	Shared Neighborhood Hits	21
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

MAD1_MOUSE
NC score	0.066073 (rank : 52)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	38	Target Neighborhood Hits	75	Shared Neighborhood Hits	14
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

EPAS1_MOUSE
NC score	0.065676 (rank : 53)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	38	Target Neighborhood Hits	94	Shared Neighborhood Hits	13
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
NC score	0.064582 (rank : 54)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	38	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.062725 (rank : 55)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	38	Target Neighborhood Hits	90	Shared Neighborhood Hits	14
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

EPAS1_HUMAN
NC score	0.061536 (rank : 56)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	38	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

NPAS3_MOUSE
NC score	0.061246 (rank : 57)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	38	Target Neighborhood Hits	103	Shared Neighborhood Hits	16
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.061048 (rank : 58)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	38	Target Neighborhood Hits	81	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_HUMAN
NC score	0.052870 (rank : 59)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	38	Target Neighborhood Hits	77	Shared Neighborhood Hits	12
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
NC score	0.052823 (rank : 60)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	38	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

MAD1_HUMAN
NC score	0.051111 (rank : 61)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	38	Target Neighborhood Hits	68	Shared Neighborhood Hits	14
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAP1A_HUMAN
NC score	0.008666 (rank : 62)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	38	Target Neighborhood Hits	1626	Shared Neighborhood Hits	5
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

LYST_HUMAN
NC score	0.008449 (rank : 63)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	38	Target Neighborhood Hits	324	Shared Neighborhood Hits	2
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MILK1_MOUSE
NC score	0.005798 (rank : 64)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	38	Target Neighborhood Hits	788	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).