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Network neighborhood for query Sequence : ARNT_HUMAN

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ARNT_HUMAN
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARNT2_HUMAN
θ value	0 (rank : 1)	NC score	0.988031 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0 (rank : 2)	NC score	0.987210 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	74
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0 (rank : 4)	NC score	0.983049 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	213	Shared Neighborhood Hits	86
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BMAL1_MOUSE
θ value	6.48998e-91 (rank : 5)	NC score	0.939202 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
θ value	7.93343e-89 (rank : 6)	NC score	0.940974 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

NPAS2_HUMAN
θ value	1.0531e-32 (rank : 7)	NC score	0.807856 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	150	Shared Neighborhood Hits	60
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

CLOCK_MOUSE
θ value	4.42448e-31 (rank : 8)	NC score	0.810328 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_MOUSE
θ value	1.28732e-30 (rank : 9)	NC score	0.806646 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	61
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

EPAS1_MOUSE
θ value	2.86786e-30 (rank : 10)	NC score	0.788681 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

EPAS1_HUMAN
θ value	3.74554e-30 (rank : 11)	NC score	0.788852 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

CLOCK_HUMAN
θ value	6.38894e-30 (rank : 12)	NC score	0.809938 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

HIF1A_HUMAN
θ value	3.87602e-27 (rank : 13)	NC score	0.775330 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	1.47289e-26 (rank : 14)	NC score	0.776019 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM1_HUMAN
θ value	7.56453e-23 (rank : 15)	NC score	0.741966 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	62	Shared Neighborhood Hits	42
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	1.29031e-22 (rank : 16)	NC score	0.740924 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	3.17815e-21 (rank : 17)	NC score	0.736844 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	1.2077e-20 (rank : 18)	NC score	0.735500 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	41
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
θ value	2.27762e-19 (rank : 19)	NC score	0.701272 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	5.60996e-18 (rank : 20)	NC score	0.694427 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NCOA3_HUMAN
θ value	6.41864e-14 (rank : 21)	NC score	0.563631 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	171	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA1_MOUSE
θ value	1.42992e-13 (rank : 22)	NC score	0.599347 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	196	Shared Neighborhood Hits	46
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	3.18553e-13 (rank : 23)	NC score	0.595170 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

PER1_MOUSE
θ value	4.16044e-13 (rank : 24)	NC score	0.472926 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER1_HUMAN
θ value	5.43371e-13 (rank : 25)	NC score	0.475796 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	215	Shared Neighborhood Hits	33
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER2_HUMAN
θ value	7.09661e-13 (rank : 26)	NC score	0.480685 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_HUMAN
θ value	4.59992e-12 (rank : 27)	NC score	0.455744 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

NCOA3_MOUSE
θ value	3.89403e-11 (rank : 28)	NC score	0.524949 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER2_MOUSE
θ value	1.133e-10 (rank : 29)	NC score	0.449605 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	325	Shared Neighborhood Hits	27
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

NPAS1_HUMAN
θ value	1.9326e-10 (rank : 30)	NC score	0.669309 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	34
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_HUMAN
θ value	9.59137e-10 (rank : 31)	NC score	0.660566 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS1_MOUSE
θ value	9.59137e-10 (rank : 32)	NC score	0.673038 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

PER3_MOUSE
θ value	2.13673e-09 (rank : 33)	NC score	0.489704 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

NPAS4_MOUSE
θ value	3.08544e-08 (rank : 34)	NC score	0.508124 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA2_MOUSE
θ value	4.0297e-08 (rank : 35)	NC score	0.515741 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
θ value	8.97725e-08 (rank : 36)	NC score	0.514111 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

AHR_MOUSE
θ value	1.17247e-07 (rank : 37)	NC score	0.645734 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS4_HUMAN
θ value	2.61198e-07 (rank : 38)	NC score	0.524347 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

TFE3_HUMAN
θ value	0.000158464 (rank : 39)	NC score	0.267978 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	49
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF1_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.280438 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.000270298 (rank : 41)	NC score	0.280658 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

TFEB_HUMAN
θ value	0.000461057 (rank : 42)	NC score	0.258572 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	47
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	0.000461057 (rank : 43)	NC score	0.258705 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF2_HUMAN
θ value	0.000461057 (rank : 44)	NC score	0.271355 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	155	Shared Neighborhood Hits	48
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MITF_MOUSE
θ value	0.000602161 (rank : 45)	NC score	0.261769 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	53
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MYCL1_HUMAN
θ value	0.000786445 (rank : 46)	NC score	0.197420 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	0.000786445 (rank : 47)	NC score	0.202659 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	43
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

USF2_MOUSE
θ value	0.000786445 (rank : 48)	NC score	0.262084 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	173	Shared Neighborhood Hits	48
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MITF_HUMAN
θ value	0.00134147 (rank : 49)	NC score	0.255650 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	53
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HEY2_HUMAN
θ value	0.0113563 (rank : 50)	NC score	0.228171 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	0.0113563 (rank : 51)	NC score	0.225281 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MYC_HUMAN
θ value	0.0330416 (rank : 52)	NC score	0.138468 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAX_MOUSE
θ value	0.0431538 (rank : 53)	NC score	0.193555 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	42
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.183286 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYC_MOUSE
θ value	0.0736092 (rank : 55)	NC score	0.137753 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SRBP1_HUMAN
θ value	0.0736092 (rank : 56)	NC score	0.165617 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

HEY1_MOUSE
θ value	0.0961366 (rank : 57)	NC score	0.204554 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MYCN_HUMAN
θ value	0.0961366 (rank : 58)	NC score	0.140270 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MAD4_HUMAN
θ value	0.163984 (rank : 59)	NC score	0.139403 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYCN_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.137061 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

NRDC_MOUSE
θ value	0.21417 (rank : 61)	NC score	0.027860 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

TCFL5_HUMAN
θ value	0.21417 (rank : 62)	NC score	0.193817 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

HEY1_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.196791 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

BSN_HUMAN
θ value	0.365318 (rank : 64)	NC score	0.033452 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	1537	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

MARK2_MOUSE
θ value	0.47712 (rank : 65)	NC score	-0.002624 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	1018	Shared Neighborhood Hits	6
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

SRBP1_MOUSE
θ value	0.47712 (rank : 66)	NC score	0.147479 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	384	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCS_MOUSE
θ value	0.813845 (rank : 67)	NC score	0.136128 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	83	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

SRBP2_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.139568 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

HNF1A_HUMAN
θ value	1.06291 (rank : 69)	NC score	0.019427 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	P20823, Q99861	Gene names	TCF1, HNF1A
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1).

BHLH2_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.122431 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	43
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	1.38821 (rank : 71)	NC score	0.121873 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	40
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES4_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.098277 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MLL3_MOUSE
θ value	1.81305 (rank : 73)	NC score	0.027977 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	1399	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

UBR2_HUMAN
θ value	1.81305 (rank : 74)	NC score	0.024034 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

UBR2_MOUSE
θ value	1.81305 (rank : 75)	NC score	0.024113 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

MAD1_MOUSE
θ value	2.36792 (rank : 76)	NC score	0.066470 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	31
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

BHLH3_HUMAN
θ value	3.0926 (rank : 77)	NC score	0.129974 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	43
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	3.0926 (rank : 78)	NC score	0.127798 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

ELOA2_HUMAN
θ value	3.0926 (rank : 79)	NC score	0.011784 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	165	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

PPIP1_MOUSE
θ value	3.0926 (rank : 80)	NC score	0.005426 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	377	Shared Neighborhood Hits	4
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

TBX18_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.004734 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

CALD1_HUMAN
θ value	4.03905 (rank : 82)	NC score	-0.000594 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	959	Shared Neighborhood Hits	4
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

HNF1A_MOUSE
θ value	4.03905 (rank : 83)	NC score	0.023593 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	212	Shared Neighborhood Hits	9
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

LTBP2_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.001439 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	552	Shared Neighborhood Hits	4
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MDC1_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.011588 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	1446	Shared Neighborhood Hits	23
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CCAR1_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.008631 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	444	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

LEO1_MOUSE
θ value	5.27518 (rank : 87)	NC score	0.012128 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	946	Shared Neighborhood Hits	12
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LMBL2_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.016450 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P59178	Gene names	L3mbtl2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

MAD1_HUMAN
θ value	5.27518 (rank : 89)	NC score	0.056980 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	68	Shared Neighborhood Hits	28
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MLX_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.168694 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MXI1_HUMAN
θ value	5.27518 (rank : 91)	NC score	0.067785 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.068698 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

NFAT5_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.011575 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

BRD7_HUMAN
θ value	6.88961 (rank : 94)	NC score	0.005299 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

CCD12_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.011796 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUD4, Q8N8I4	Gene names	CCDC12
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 12.

MAD3_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.085911 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MCM3_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.004519 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MLX_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.162662 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCL2_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.091801 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

MYT1L_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.003758 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	461	Shared Neighborhood Hits	4
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

NCOA6_HUMAN
θ value	6.88961 (rank : 101)	NC score	0.032801 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	1202	Shared Neighborhood Hits	25
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RSF1_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.004935 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	539	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SOX30_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.007221 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	305	Shared Neighborhood Hits	7
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

SRBS1_MOUSE
θ value	6.88961 (rank : 104)	NC score	0.014609 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	409	Shared Neighborhood Hits	7
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

AB1IP_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.006180 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

AN32B_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.003397 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

M3K7_HUMAN
θ value	8.99809 (rank : 107)	NC score	-0.004905 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	892	Shared Neighborhood Hits	3
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

PABP4_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.001107 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q13310, Q6P0N3	Gene names	PABPC4, APP1, PABP4
Domain Architecture
Description	Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein 1) (APP-1).

PF21B_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.014139 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	278	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

HES1_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.076103 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.076331 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES3_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.065116 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.092928 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES7_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.061988 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.060068 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD3_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.063429 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	31
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD4_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.062312 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MNT_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.070782 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	496	Shared Neighborhood Hits	43
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.067526 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	432	Shared Neighborhood Hits	39
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCB_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.051148 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

Hits sorted by NC score

ARNT_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	109
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
NC score	0.988031 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	74
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.987210 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	74
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_MOUSE
NC score	0.983049 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	109	Target Neighborhood Hits	213	Shared Neighborhood Hits	86
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BMAL1_HUMAN
NC score	0.940974 (rank : 5)	θ value	7.93343e-89 (rank : 6)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.939202 (rank : 6)	θ value	6.48998e-91 (rank : 5)
Query Neighborhood Hits	109	Target Neighborhood Hits	121	Shared Neighborhood Hits	70
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_MOUSE
NC score	0.810328 (rank : 7)	θ value	4.42448e-31 (rank : 8)
Query Neighborhood Hits	109	Target Neighborhood Hits	148	Shared Neighborhood Hits	63
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
NC score	0.809938 (rank : 8)	θ value	6.38894e-30 (rank : 12)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	62
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

NPAS2_HUMAN
NC score	0.807856 (rank : 9)	θ value	1.0531e-32 (rank : 7)
Query Neighborhood Hits	109	Target Neighborhood Hits	150	Shared Neighborhood Hits	60
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.806646 (rank : 10)	θ value	1.28732e-30 (rank : 9)
Query Neighborhood Hits	109	Target Neighborhood Hits	132	Shared Neighborhood Hits	61
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

EPAS1_HUMAN
NC score	0.788852 (rank : 11)	θ value	3.74554e-30 (rank : 11)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.788681 (rank : 12)	θ value	2.86786e-30 (rank : 10)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_MOUSE
NC score	0.776019 (rank : 13)	θ value	1.47289e-26 (rank : 14)
Query Neighborhood Hits	109	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.775330 (rank : 14)	θ value	3.87602e-27 (rank : 13)
Query Neighborhood Hits	109	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

SIM1_HUMAN
NC score	0.741966 (rank : 15)	θ value	7.56453e-23 (rank : 15)
Query Neighborhood Hits	109	Target Neighborhood Hits	62	Shared Neighborhood Hits	42
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.740924 (rank : 16)	θ value	1.29031e-22 (rank : 16)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	42
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
NC score	0.736844 (rank : 17)	θ value	3.17815e-21 (rank : 17)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.735500 (rank : 18)	θ value	1.2077e-20 (rank : 18)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	41
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
NC score	0.701272 (rank : 19)	θ value	2.27762e-19 (rank : 19)
Query Neighborhood Hits	109	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.694427 (rank : 20)	θ value	5.60996e-18 (rank : 20)
Query Neighborhood Hits	109	Target Neighborhood Hits	81	Shared Neighborhood Hits	38
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
NC score	0.673038 (rank : 21)	θ value	9.59137e-10 (rank : 32)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.669309 (rank : 22)	θ value	1.9326e-10 (rank : 30)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	34
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

AHR_HUMAN
NC score	0.660566 (rank : 23)	θ value	9.59137e-10 (rank : 31)
Query Neighborhood Hits	109	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.645734 (rank : 24)	θ value	1.17247e-07 (rank : 37)
Query Neighborhood Hits	109	Target Neighborhood Hits	55	Shared Neighborhood Hits	33
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA1_MOUSE
NC score	0.599347 (rank : 25)	θ value	1.42992e-13 (rank : 22)
Query Neighborhood Hits	109	Target Neighborhood Hits	196	Shared Neighborhood Hits	46
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.595170 (rank : 26)	θ value	3.18553e-13 (rank : 23)
Query Neighborhood Hits	109	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA3_HUMAN
NC score	0.563631 (rank : 27)	θ value	6.41864e-14 (rank : 21)
Query Neighborhood Hits	109	Target Neighborhood Hits	171	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.524949 (rank : 28)	θ value	3.89403e-11 (rank : 28)
Query Neighborhood Hits	109	Target Neighborhood Hits	203	Shared Neighborhood Hits	34
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS4_HUMAN
NC score	0.524347 (rank : 29)	θ value	2.61198e-07 (rank : 38)
Query Neighborhood Hits	109	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NCOA2_MOUSE
NC score	0.515741 (rank : 30)	θ value	4.0297e-08 (rank : 35)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA2_HUMAN
NC score	0.514111 (rank : 31)	θ value	8.97725e-08 (rank : 36)
Query Neighborhood Hits	109	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NPAS4_MOUSE
NC score	0.508124 (rank : 32)	θ value	3.08544e-08 (rank : 34)
Query Neighborhood Hits	109	Target Neighborhood Hits	245	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PER3_MOUSE
NC score	0.489704 (rank : 33)	θ value	2.13673e-09 (rank : 33)
Query Neighborhood Hits	109	Target Neighborhood Hits	85	Shared Neighborhood Hits	28
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.480685 (rank : 34)	θ value	7.09661e-13 (rank : 26)
Query Neighborhood Hits	109	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.475796 (rank : 35)	θ value	5.43371e-13 (rank : 25)
Query Neighborhood Hits	109	Target Neighborhood Hits	215	Shared Neighborhood Hits	33
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.472926 (rank : 36)	θ value	4.16044e-13 (rank : 24)
Query Neighborhood Hits	109	Target Neighborhood Hits	235	Shared Neighborhood Hits	31
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.455744 (rank : 37)	θ value	4.59992e-12 (rank : 27)
Query Neighborhood Hits	109	Target Neighborhood Hits	479	Shared Neighborhood Hits	32
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.449605 (rank : 38)	θ value	1.133e-10 (rank : 29)
Query Neighborhood Hits	109	Target Neighborhood Hits	325	Shared Neighborhood Hits	27
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

USF1_MOUSE
NC score	0.280658 (rank : 39)	θ value	0.000270298 (rank : 41)
Query Neighborhood Hits	109	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.280438 (rank : 40)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.271355 (rank : 41)	θ value	0.000461057 (rank : 44)
Query Neighborhood Hits	109	Target Neighborhood Hits	155	Shared Neighborhood Hits	48
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

TFE3_HUMAN
NC score	0.267978 (rank : 42)	θ value	0.000158464 (rank : 39)
Query Neighborhood Hits	109	Target Neighborhood Hits	190	Shared Neighborhood Hits	49
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF2_MOUSE
NC score	0.262084 (rank : 43)	θ value	0.000786445 (rank : 48)
Query Neighborhood Hits	109	Target Neighborhood Hits	173	Shared Neighborhood Hits	48
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MITF_MOUSE
NC score	0.261769 (rank : 44)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	109	Target Neighborhood Hits	115	Shared Neighborhood Hits	53
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.258705 (rank : 45)	θ value	0.000461057 (rank : 43)
Query Neighborhood Hits	109	Target Neighborhood Hits	119	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.258572 (rank : 46)	θ value	0.000461057 (rank : 42)
Query Neighborhood Hits	109	Target Neighborhood Hits	111	Shared Neighborhood Hits	47
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MITF_HUMAN
NC score	0.255650 (rank : 47)	θ value	0.00134147 (rank : 49)
Query Neighborhood Hits	109	Target Neighborhood Hits	113	Shared Neighborhood Hits	53
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HEY2_HUMAN
NC score	0.228171 (rank : 48)	θ value	0.0113563 (rank : 50)
Query Neighborhood Hits	109	Target Neighborhood Hits	77	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.225281 (rank : 49)	θ value	0.0113563 (rank : 51)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.204554 (rank : 50)	θ value	0.0961366 (rank : 57)
Query Neighborhood Hits	109	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MYCL1_MOUSE
NC score	0.202659 (rank : 51)	θ value	0.000786445 (rank : 47)
Query Neighborhood Hits	109	Target Neighborhood Hits	123	Shared Neighborhood Hits	43
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_HUMAN
NC score	0.197420 (rank : 52)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HEY1_HUMAN
NC score	0.196791 (rank : 53)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	109	Target Neighborhood Hits	82	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

TCFL5_HUMAN
NC score	0.193817 (rank : 54)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	109	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MAX_MOUSE
NC score	0.193555 (rank : 55)	θ value	0.0431538 (rank : 53)
Query Neighborhood Hits	109	Target Neighborhood Hits	139	Shared Neighborhood Hits	42
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.183286 (rank : 56)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	41
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MLX_MOUSE
NC score	0.168694 (rank : 57)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	109	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_HUMAN
NC score	0.165617 (rank : 58)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	109	Target Neighborhood Hits	225	Shared Neighborhood Hits	49
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MLX_HUMAN
NC score	0.162662 (rank : 59)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	109	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_MOUSE
NC score	0.147479 (rank : 60)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	109	Target Neighborhood Hits	384	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCN_HUMAN
NC score	0.140270 (rank : 61)	θ value	0.0961366 (rank : 58)
Query Neighborhood Hits	109	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

SRBP2_HUMAN
NC score	0.139568 (rank : 62)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	109	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MAD4_HUMAN
NC score	0.139403 (rank : 63)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	38
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYC_HUMAN
NC score	0.138468 (rank : 64)	θ value	0.0330416 (rank : 52)
Query Neighborhood Hits	109	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
NC score	0.137753 (rank : 65)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_MOUSE
NC score	0.137061 (rank : 66)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	109	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCS_MOUSE
NC score	0.136128 (rank : 67)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	109	Target Neighborhood Hits	83	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

BHLH3_HUMAN
NC score	0.129974 (rank : 68)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	109	Target Neighborhood Hits	106	Shared Neighborhood Hits	43
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.127798 (rank : 69)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_HUMAN
NC score	0.122431 (rank : 70)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	109	Target Neighborhood Hits	80	Shared Neighborhood Hits	43
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.121873 (rank : 71)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	109	Target Neighborhood Hits	70	Shared Neighborhood Hits	40
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES4_HUMAN
NC score	0.098277 (rank : 72)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES5_MOUSE
NC score	0.092928 (rank : 73)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MYCL2_HUMAN
NC score	0.091801 (rank : 74)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	109	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

MAD3_HUMAN
NC score	0.085911 (rank : 75)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	109	Target Neighborhood Hits	92	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

HES1_MOUSE
NC score	0.076331 (rank : 76)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	109	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.076103 (rank : 77)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	32
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

MNT_HUMAN
NC score	0.070782 (rank : 78)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	109	Target Neighborhood Hits	496	Shared Neighborhood Hits	43
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MXI1_MOUSE
NC score	0.068698 (rank : 79)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	109	Target Neighborhood Hits	109	Shared Neighborhood Hits	35
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
NC score	0.067785 (rank : 80)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	109	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MNT_MOUSE
NC score	0.067526 (rank : 81)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	109	Target Neighborhood Hits	432	Shared Neighborhood Hits	39
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MAD1_MOUSE
NC score	0.066470 (rank : 82)	θ value	2.36792 (rank : 76)
Query Neighborhood Hits	109	Target Neighborhood Hits	75	Shared Neighborhood Hits	31
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

HES3_MOUSE
NC score	0.065116 (rank : 83)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	109	Target Neighborhood Hits	38	Shared Neighborhood Hits	16
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MAD3_MOUSE
NC score	0.063429 (rank : 84)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	31
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD4_MOUSE
NC score	0.062312 (rank : 85)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	109	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HES7_HUMAN
NC score	0.061988 (rank : 86)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.060068 (rank : 87)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	109	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD1_HUMAN
NC score	0.056980 (rank : 88)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	109	Target Neighborhood Hits	68	Shared Neighborhood Hits	28
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MYCB_MOUSE
NC score	0.051148 (rank : 89)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	109	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

BSN_HUMAN
NC score	0.033452 (rank : 90)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	109	Target Neighborhood Hits	1537	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

NCOA6_HUMAN
NC score	0.032801 (rank : 91)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	109	Target Neighborhood Hits	1202	Shared Neighborhood Hits	25
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MLL3_MOUSE
NC score	0.027977 (rank : 92)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	109	Target Neighborhood Hits	1399	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

NRDC_MOUSE
NC score	0.027860 (rank : 93)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	109	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

UBR2_MOUSE
NC score	0.024113 (rank : 94)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	109	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q6WKZ8, Q6DIB9, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130	Gene names	Ubr2, Kiaa0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

UBR2_HUMAN
NC score	0.024034 (rank : 95)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	109	Target Neighborhood Hits	45	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWV8, O15057, Q4VXK2, Q5TFH6, Q6P2I2, Q6ZUD0	Gene names	UBR2, C6orf133, KIAA0349
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3 component N-recognin-2 (EC 6.-.-.-) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3- alpha-II).

HNF1A_MOUSE
NC score	0.023593 (rank : 96)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	109	Target Neighborhood Hits	212	Shared Neighborhood Hits	9
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

HNF1A_HUMAN
NC score	0.019427 (rank : 97)	θ value	1.06291 (rank : 69)
Query Neighborhood Hits	109	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	P20823, Q99861	Gene names	TCF1, HNF1A
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1).

LMBL2_MOUSE
NC score	0.016450 (rank : 98)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	109	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P59178	Gene names	L3mbtl2
Domain Architecture
Description	Lethal(3)malignant brain tumor-like 2 protein (L(3)mbt-like 2 protein) (H-l(3)mbt-like protein).

SRBS1_MOUSE
NC score	0.014609 (rank : 99)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	109	Target Neighborhood Hits	409	Shared Neighborhood Hits	7
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PF21B_MOUSE
NC score	0.014139 (rank : 100)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	109	Target Neighborhood Hits	278	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

LEO1_MOUSE
NC score	0.012128 (rank : 101)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	109	Target Neighborhood Hits	946	Shared Neighborhood Hits	12
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

CCD12_HUMAN
NC score	0.011796 (rank : 102)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	109	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUD4, Q8N8I4	Gene names	CCDC12
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 12.

ELOA2_HUMAN
NC score	0.011784 (rank : 103)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	109	Target Neighborhood Hits	165	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYF1, Q9P2V9	Gene names	TCEB3B, TCEB3L
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A2 (Elongin-A2) (EloA2) (Transcription elongation factor B polypeptide 3B).

MDC1_HUMAN
NC score	0.011588 (rank : 104)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	109	Target Neighborhood Hits	1446	Shared Neighborhood Hits	23
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NFAT5_HUMAN
NC score	0.011575 (rank : 105)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	109	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	O94916, O95693, Q9UN18	Gene names	NFAT5, KIAA0827, TONEBP
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T-cell transcription factor NFAT5) (NF-AT5) (Tonicity-responsive enhancer-binding protein) (TonE- binding protein) (TonEBP).

CCAR1_HUMAN
NC score	0.008631 (rank : 106)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	109	Target Neighborhood Hits	444	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

SOX30_HUMAN
NC score	0.007221 (rank : 107)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	109	Target Neighborhood Hits	305	Shared Neighborhood Hits	7
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

AB1IP_MOUSE
NC score	0.006180 (rank : 108)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	109	Target Neighborhood Hits	181	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

PPIP1_MOUSE
NC score	0.005426 (rank : 109)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	109	Target Neighborhood Hits	377	Shared Neighborhood Hits	4
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

BRD7_HUMAN
NC score	0.005299 (rank : 110)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	109	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPI1, Q4VC09, Q8N2L9, Q96KA4, Q9BV48, Q9UH59	Gene names	BRD7, BP75, CELTIX1
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1).

RSF1_HUMAN
NC score	0.004935 (rank : 111)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	109	Target Neighborhood Hits	539	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

TBX18_MOUSE
NC score	0.004734 (rank : 112)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	109	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EPZ6	Gene names	Tbx18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

MCM3_HUMAN
NC score	0.004519 (rank : 113)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	109	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	P25205, Q92660, Q9BTR3, Q9NUE7	Gene names	MCM3
Domain Architecture
Description	DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF subunit beta) (P102 protein) (P1-MCM3).

MYT1L_MOUSE
NC score	0.003758 (rank : 114)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	109	Target Neighborhood Hits	461	Shared Neighborhood Hits	4
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

AN32B_HUMAN
NC score	0.003397 (rank : 115)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	109	Target Neighborhood Hits	243	Shared Neighborhood Hits	3
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

LTBP2_HUMAN
NC score	0.001439 (rank : 116)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	109	Target Neighborhood Hits	552	Shared Neighborhood Hits	4
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

PABP4_HUMAN
NC score	0.001107 (rank : 117)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	109	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q13310, Q6P0N3	Gene names	PABPC4, APP1, PABP4
Domain Architecture
Description	Polyadenylate-binding protein 4 (Poly(A)-binding protein 4) (PABP 4) (Inducible poly(A)-binding protein) (iPABP) (Activated-platelet protein 1) (APP-1).

CALD1_HUMAN
NC score	-0.000594 (rank : 118)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	109	Target Neighborhood Hits	959	Shared Neighborhood Hits	4
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

MARK2_MOUSE
NC score	-0.002624 (rank : 119)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	109	Target Neighborhood Hits	1018	Shared Neighborhood Hits	6
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

M3K7_HUMAN
NC score	-0.004905 (rank : 120)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	109	Target Neighborhood Hits	892	Shared Neighborhood Hits	3
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).