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Network neighborhood for query Sequence : TFEB_MOUSE

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TFEB_MOUSE
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TFEB_MOUSE
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
θ value	5.35569e-178 (rank : 2)	NC score	0.992155 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	92
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MITF_HUMAN
θ value	6.08852e-81 (rank : 3)	NC score	0.940577 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	113	Shared Neighborhood Hits	63
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	2.82823e-78 (rank : 4)	NC score	0.940326 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
θ value	1.45253e-74 (rank : 5)	NC score	0.922072 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	66
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF2_HUMAN
θ value	1.80886e-08 (rank : 6)	NC score	0.503856 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	54
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	2.36244e-08 (rank : 7)	NC score	0.498396 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	173	Shared Neighborhood Hits	55
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

SRBP1_MOUSE
θ value	1.43324e-05 (rank : 8)	NC score	0.361173 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	384	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	2.44474e-05 (rank : 9)	NC score	0.387287 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
θ value	3.19293e-05 (rank : 10)	NC score	0.376257 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

USF1_HUMAN
θ value	4.1701e-05 (rank : 11)	NC score	0.473820 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	49
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	4.1701e-05 (rank : 12)	NC score	0.474623 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	71	Shared Neighborhood Hits	49
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

ARNT_HUMAN
θ value	0.000461057 (rank : 13)	NC score	0.258705 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0.000461057 (rank : 14)	NC score	0.255152 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	213	Shared Neighborhood Hits	49
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_MOUSE
θ value	0.00390308 (rank : 15)	NC score	0.211072 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD4_HUMAN
θ value	0.00390308 (rank : 16)	NC score	0.267924 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	41
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

CLOCK_HUMAN
θ value	0.00665767 (rank : 17)	NC score	0.206747 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MNT_MOUSE
θ value	0.00665767 (rank : 18)	NC score	0.221522 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	432	Shared Neighborhood Hits	43
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ARNT2_HUMAN
θ value	0.00869519 (rank : 19)	NC score	0.231682 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0.00869519 (rank : 20)	NC score	0.232153 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

BMAL1_HUMAN
θ value	0.00869519 (rank : 21)	NC score	0.231011 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.00869519 (rank : 22)	NC score	0.230760 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	121	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

HEY2_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.264308 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

MNT_HUMAN
θ value	0.0148317 (rank : 24)	NC score	0.210558 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	496	Shared Neighborhood Hits	46
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HEY2_MOUSE
θ value	0.0431538 (rank : 25)	NC score	0.260350 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
θ value	0.0563607 (rank : 26)	NC score	0.252423 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
θ value	0.0736092 (rank : 27)	NC score	0.242074 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	82	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MAX_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.325690 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	46
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	0.0961366 (rank : 29)	NC score	0.324419 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

XE7_HUMAN
θ value	0.0961366 (rank : 30)	NC score	0.065169 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	738	Shared Neighborhood Hits	24
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

NDF1_MOUSE
θ value	0.125558 (rank : 31)	NC score	0.039935 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

TCFL5_HUMAN
θ value	0.125558 (rank : 32)	NC score	0.196580 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MYC_HUMAN
θ value	0.163984 (rank : 33)	NC score	0.222122 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SOX5_HUMAN
θ value	0.163984 (rank : 34)	NC score	0.041736 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

MLX_MOUSE
θ value	0.21417 (rank : 35)	NC score	0.241411 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

PALM_HUMAN
θ value	0.365318 (rank : 36)	NC score	0.077194 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	O75781, O43359, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3	Gene names	PALM, KIAA0270
Domain Architecture
Description	Paralemmin.

HES1_HUMAN
θ value	0.47712 (rank : 37)	NC score	0.195020 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.47712 (rank : 38)	NC score	0.196051 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MYCN_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.222917 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCL1_MOUSE
θ value	0.62314 (rank : 40)	NC score	0.193597 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCS_MOUSE
θ value	0.62314 (rank : 41)	NC score	0.209995 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.209317 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SOX9_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.034379 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	210	Shared Neighborhood Hits	11
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

FYCO1_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.019011 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	1149	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

MXI1_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.203506 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	0.813845 (rank : 46)	NC score	0.203287 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCL1_HUMAN
θ value	0.813845 (rank : 47)	NC score	0.192864 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCN_HUMAN
θ value	0.813845 (rank : 48)	NC score	0.232756 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

SOX9_MOUSE
θ value	0.813845 (rank : 49)	NC score	0.031191 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

WBS14_HUMAN
θ value	0.813845 (rank : 50)	NC score	0.127496 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	273	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

MAD3_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.194557 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MRCKB_MOUSE
θ value	1.06291 (rank : 52)	NC score	0.005842 (rank : 146)
Query Neighborhood Hits	119	Target Neighborhood Hits	2180	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NDF1_HUMAN
θ value	1.06291 (rank : 53)	NC score	0.034979 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	186	Shared Neighborhood Hits	17
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

PALM_MOUSE
θ value	1.06291 (rank : 54)	NC score	0.064052 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

CCD41_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.020421 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	1139	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

TFAP4_HUMAN
θ value	1.38821 (rank : 56)	NC score	0.211826 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	47
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

WWC1_MOUSE
θ value	1.38821 (rank : 57)	NC score	0.034850 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

JUN_MOUSE
θ value	1.81305 (rank : 58)	NC score	0.028250 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	P05627	Gene names	Jun
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A) (AH119).

LAMA1_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.012677 (rank : 135)
Query Neighborhood Hits	119	Target Neighborhood Hits	838	Shared Neighborhood Hits	16
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

NCOA6_MOUSE
θ value	2.36792 (rank : 60)	NC score	0.033363 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	1076	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PSCBP_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.028222 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

TNIK_HUMAN
θ value	2.36792 (rank : 62)	NC score	0.005658 (rank : 147)
Query Neighborhood Hits	119	Target Neighborhood Hits	1570	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

BCL9_MOUSE
θ value	3.0926 (rank : 63)	NC score	0.027057 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	770	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BHLH3_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.144989 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	106	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	3.0926 (rank : 65)	NC score	0.142963 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

CAC1S_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.010164 (rank : 139)
Query Neighborhood Hits	119	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

HES4_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.178321 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

IF140_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.031018 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

MAD3_HUMAN
θ value	3.0926 (rank : 69)	NC score	0.211359 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	92	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

NPAS2_HUMAN
θ value	3.0926 (rank : 70)	NC score	0.151452 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.151286 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	132	Shared Neighborhood Hits	38
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

SNPC4_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.030971 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	237	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

CASP_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.012976 (rank : 132)
Query Neighborhood Hits	119	Target Neighborhood Hits	1131	Shared Neighborhood Hits	27
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

DMD_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.009447 (rank : 142)
Query Neighborhood Hits	119	Target Neighborhood Hits	1135	Shared Neighborhood Hits	19
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

HIP1R_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.015345 (rank : 128)
Query Neighborhood Hits	119	Target Neighborhood Hits	809	Shared Neighborhood Hits	19
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

JUN_HUMAN
θ value	4.03905 (rank : 76)	NC score	0.025649 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	8
SwissProt Accessions	P05412, Q96G93	Gene names	JUN
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39).

MYCL2_HUMAN
θ value	4.03905 (rank : 77)	NC score	0.156604 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

MYO5C_HUMAN
θ value	4.03905 (rank : 78)	NC score	0.010356 (rank : 138)
Query Neighborhood Hits	119	Target Neighborhood Hits	1206	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NCOA6_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.031970 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	1202	Shared Neighborhood Hits	26
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RPGR1_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.022111 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	713	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CAC1S_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.009469 (rank : 141)
Query Neighborhood Hits	119	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

ITF2_HUMAN
θ value	5.27518 (rank : 82)	NC score	0.031232 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

MLL3_HUMAN
θ value	5.27518 (rank : 83)	NC score	0.016777 (rank : 122)
Query Neighborhood Hits	119	Target Neighborhood Hits	1644	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PGCA_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.004399 (rank : 149)
Query Neighborhood Hits	119	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

RIOK2_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.015918 (rank : 126)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

TXND2_HUMAN
θ value	5.27518 (rank : 86)	NC score	0.020906 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	793	Shared Neighborhood Hits	14
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

BCL9_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.026677 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	1008	Shared Neighborhood Hits	23
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BHLH4_MOUSE
θ value	6.88961 (rank : 88)	NC score	0.027495 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

CCD41_MOUSE
θ value	6.88961 (rank : 89)	NC score	0.015365 (rank : 127)
Query Neighborhood Hits	119	Target Neighborhood Hits	1399	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CS021_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.022017 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

FOXN1_MOUSE
θ value	6.88961 (rank : 91)	NC score	0.004673 (rank : 148)
Query Neighborhood Hits	119	Target Neighborhood Hits	300	Shared Neighborhood Hits	4
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

GRB10_MOUSE
θ value	6.88961 (rank : 92)	NC score	0.006847 (rank : 144)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

HGS_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.021251 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	517	Shared Neighborhood Hits	20
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.019337 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

IFM2_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.027091 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q01629, Q96DA8	Gene names	IFITM2
Domain Architecture
Description	Interferon-induced transmembrane protein 2 (Interferon-inducible protein 1-8D).

MKL1_MOUSE
θ value	6.88961 (rank : 96)	NC score	0.016576 (rank : 123)
Query Neighborhood Hits	119	Target Neighborhood Hits	667	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

NIN_HUMAN
θ value	6.88961 (rank : 97)	NC score	0.013724 (rank : 131)
Query Neighborhood Hits	119	Target Neighborhood Hits	1416	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NPAS1_HUMAN
θ value	6.88961 (rank : 98)	NC score	0.061330 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

TAL1_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.064078 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	6.88961 (rank : 100)	NC score	0.062188 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	24
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

AKAP9_HUMAN
θ value	8.99809 (rank : 101)	NC score	0.012791 (rank : 134)
Query Neighborhood Hits	119	Target Neighborhood Hits	1710	Shared Neighborhood Hits	33
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BHLH2_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.115236 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

CK035_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.012858 (rank : 133)
Query Neighborhood Hits	119	Target Neighborhood Hits	149	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

E2F2_MOUSE
θ value	8.99809 (rank : 104)	NC score	0.006650 (rank : 145)
Query Neighborhood Hits	119	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

FXR1_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.006933 (rank : 143)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q61584, Q8VCU4, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9	Gene names	Fxr1, Fxr1h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (mFxr1p).

FYCO1_MOUSE
θ value	8.99809 (rank : 106)	NC score	0.019666 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GCC2_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.012333 (rank : 136)
Query Neighborhood Hits	119	Target Neighborhood Hits	1619	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

HES6_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.089279 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES7_HUMAN
θ value	8.99809 (rank : 109)	NC score	0.086174 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.083238 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HSPB8_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.014290 (rank : 129)
Query Neighborhood Hits	119	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JK92	Gene names	Hspb8, Cryac, Hsp22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22).

LIFR_MOUSE
θ value	8.99809 (rank : 112)	NC score	0.009575 (rank : 140)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

MYH9_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.016574 (rank : 125)
Query Neighborhood Hits	119	Target Neighborhood Hits	1762	Shared Neighborhood Hits	44
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

OBSCN_HUMAN
θ value	8.99809 (rank : 114)	NC score	-0.001817 (rank : 150)
Query Neighborhood Hits	119	Target Neighborhood Hits	1931	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

SON_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.024447 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SPC24_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.013827 (rank : 130)
Query Neighborhood Hits	119	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

STX7_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.011793 (rank : 137)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	7
SwissProt Accessions	O15400, Q5SZW2, Q96ES9	Gene names	STX7
Domain Architecture
Description	Syntaxin-7.

THOC2_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.016575 (rank : 124)
Query Neighborhood Hits	119	Target Neighborhood Hits	337	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NI27, Q9H8I6	Gene names	THOC2, CXorf3
Domain Architecture	No domain graphic available
Description	THO complex subunit 2 (Tho2).

TRAIP_MOUSE
θ value	8.99809 (rank : 119)	NC score	0.018242 (rank : 121)
Query Neighborhood Hits	119	Target Neighborhood Hits	745	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

AHR_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.067217 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.057871 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BHLH2_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.101771 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

EPAS1_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.071817 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.071256 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HES2_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.062755 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.065651 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.058970 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.084680 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.086473 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HIF1A_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.069185 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.068444 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

MAD1_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.114541 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.116047 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD4_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.105815 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MLX_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.198261 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCB_MOUSE
θ value	θ > 10 (rank : 136)	NC score	0.056647 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

NCOA1_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.071564 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.071809 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA3_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.054129 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NPAS1_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.055388 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.059686 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	81	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	θ > 10 (rank : 142)	NC score	0.061076 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	103	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PER1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.050679 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.052992 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

RNC_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.063465 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

SIM1_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.064258 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.064370 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.065537 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.064469 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

WBS14_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.102517 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

Hits sorted by NC score

TFEB_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	119	Target Neighborhood Hits	119	Shared Neighborhood Hits	119
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.992155 (rank : 2)	θ value	5.35569e-178 (rank : 2)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	92
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

MITF_HUMAN
NC score	0.940577 (rank : 3)	θ value	6.08852e-81 (rank : 3)
Query Neighborhood Hits	119	Target Neighborhood Hits	113	Shared Neighborhood Hits	63
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.940326 (rank : 4)	θ value	2.82823e-78 (rank : 4)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.922072 (rank : 5)	θ value	1.45253e-74 (rank : 5)
Query Neighborhood Hits	119	Target Neighborhood Hits	190	Shared Neighborhood Hits	66
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF2_HUMAN
NC score	0.503856 (rank : 6)	θ value	1.80886e-08 (rank : 6)
Query Neighborhood Hits	119	Target Neighborhood Hits	155	Shared Neighborhood Hits	54
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.498396 (rank : 7)	θ value	2.36244e-08 (rank : 7)
Query Neighborhood Hits	119	Target Neighborhood Hits	173	Shared Neighborhood Hits	55
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF1_MOUSE
NC score	0.474623 (rank : 8)	θ value	4.1701e-05 (rank : 12)
Query Neighborhood Hits	119	Target Neighborhood Hits	71	Shared Neighborhood Hits	49
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.473820 (rank : 9)	θ value	4.1701e-05 (rank : 11)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	49
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

SRBP2_HUMAN
NC score	0.387287 (rank : 10)	θ value	2.44474e-05 (rank : 9)
Query Neighborhood Hits	119	Target Neighborhood Hits	133	Shared Neighborhood Hits	49
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
NC score	0.376257 (rank : 11)	θ value	3.19293e-05 (rank : 10)
Query Neighborhood Hits	119	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.361173 (rank : 12)	θ value	1.43324e-05 (rank : 8)
Query Neighborhood Hits	119	Target Neighborhood Hits	384	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAX_HUMAN
NC score	0.325690 (rank : 13)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	46
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
NC score	0.324419 (rank : 14)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	119	Target Neighborhood Hits	139	Shared Neighborhood Hits	48
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAD4_HUMAN
NC score	0.267924 (rank : 15)	θ value	0.00390308 (rank : 16)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	41
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HEY2_HUMAN
NC score	0.264308 (rank : 16)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.260350 (rank : 17)	θ value	0.0431538 (rank : 25)
Query Neighborhood Hits	119	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

ARNT_HUMAN
NC score	0.258705 (rank : 18)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.255152 (rank : 19)	θ value	0.000461057 (rank : 14)
Query Neighborhood Hits	119	Target Neighborhood Hits	213	Shared Neighborhood Hits	49
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

HEY1_MOUSE
NC score	0.252423 (rank : 20)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.242074 (rank : 21)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	119	Target Neighborhood Hits	82	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

MLX_MOUSE
NC score	0.241411 (rank : 22)	θ value	0.21417 (rank : 35)
Query Neighborhood Hits	119	Target Neighborhood Hits	100	Shared Neighborhood Hits	43
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCN_HUMAN
NC score	0.232756 (rank : 23)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	38
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

ARNT2_MOUSE
NC score	0.232153 (rank : 24)	θ value	0.00869519 (rank : 20)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.231682 (rank : 25)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

BMAL1_HUMAN
NC score	0.231011 (rank : 26)	θ value	0.00869519 (rank : 21)
Query Neighborhood Hits	119	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.230760 (rank : 27)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	119	Target Neighborhood Hits	121	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MYCN_MOUSE
NC score	0.222917 (rank : 28)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	39
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_HUMAN
NC score	0.222122 (rank : 29)	θ value	0.163984 (rank : 33)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	41
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MNT_MOUSE
NC score	0.221522 (rank : 30)	θ value	0.00665767 (rank : 18)
Query Neighborhood Hits	119	Target Neighborhood Hits	432	Shared Neighborhood Hits	43
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

TFAP4_HUMAN
NC score	0.211826 (rank : 31)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	119	Target Neighborhood Hits	289	Shared Neighborhood Hits	47
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MAD3_HUMAN
NC score	0.211359 (rank : 32)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	119	Target Neighborhood Hits	92	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

CLOCK_MOUSE
NC score	0.211072 (rank : 33)	θ value	0.00390308 (rank : 15)
Query Neighborhood Hits	119	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MNT_HUMAN
NC score	0.210558 (rank : 34)	θ value	0.0148317 (rank : 24)
Query Neighborhood Hits	119	Target Neighborhood Hits	496	Shared Neighborhood Hits	46
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCS_MOUSE
NC score	0.209995 (rank : 35)	θ value	0.62314 (rank : 41)
Query Neighborhood Hits	119	Target Neighborhood Hits	83	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_MOUSE
NC score	0.209317 (rank : 36)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

CLOCK_HUMAN
NC score	0.206747 (rank : 37)	θ value	0.00665767 (rank : 17)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MXI1_HUMAN
NC score	0.203506 (rank : 38)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
NC score	0.203287 (rank : 39)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	119	Target Neighborhood Hits	109	Shared Neighborhood Hits	39
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MLX_HUMAN
NC score	0.198261 (rank : 40)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	119	Target Neighborhood Hits	95	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TCFL5_HUMAN
NC score	0.196580 (rank : 41)	θ value	0.125558 (rank : 32)
Query Neighborhood Hits	119	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

HES1_MOUSE
NC score	0.196051 (rank : 42)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	119	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.195020 (rank : 43)	θ value	0.47712 (rank : 37)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

MAD3_MOUSE
NC score	0.194557 (rank : 44)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	32
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MYCL1_MOUSE
NC score	0.193597 (rank : 45)	θ value	0.62314 (rank : 40)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	44
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_HUMAN
NC score	0.192864 (rank : 46)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	119	Target Neighborhood Hits	146	Shared Neighborhood Hits	46
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HES4_HUMAN
NC score	0.178321 (rank : 47)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	119	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MYCL2_HUMAN
NC score	0.156604 (rank : 48)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

NPAS2_HUMAN
NC score	0.151452 (rank : 49)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	119	Target Neighborhood Hits	150	Shared Neighborhood Hits	37
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.151286 (rank : 50)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	119	Target Neighborhood Hits	132	Shared Neighborhood Hits	38
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

BHLH3_HUMAN
NC score	0.144989 (rank : 51)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	119	Target Neighborhood Hits	106	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.142963 (rank : 52)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

WBS14_HUMAN
NC score	0.127496 (rank : 53)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	119	Target Neighborhood Hits	273	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

MAD1_MOUSE
NC score	0.116047 (rank : 54)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	119	Target Neighborhood Hits	75	Shared Neighborhood Hits	36
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

BHLH2_HUMAN
NC score	0.115236 (rank : 55)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	119	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

MAD1_HUMAN
NC score	0.114541 (rank : 56)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	119	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD4_MOUSE
NC score	0.105815 (rank : 57)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	119	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

WBS14_MOUSE
NC score	0.102517 (rank : 58)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

BHLH2_MOUSE
NC score	0.101771 (rank : 59)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	119	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES6_HUMAN
NC score	0.089279 (rank : 60)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.086473 (rank : 61)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	19
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_HUMAN
NC score	0.086174 (rank : 62)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	119	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES5_MOUSE
NC score	0.084680 (rank : 63)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES7_MOUSE
NC score	0.083238 (rank : 64)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	119	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

PALM_HUMAN
NC score	0.077194 (rank : 65)	θ value	0.365318 (rank : 36)
Query Neighborhood Hits	119	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	O75781, O43359, O95673, Q92559, Q9UPJ4, Q9UQS2, Q9UQS3	Gene names	PALM, KIAA0270
Domain Architecture
Description	Paralemmin.

EPAS1_HUMAN
NC score	0.071817 (rank : 66)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

NCOA1_MOUSE
NC score	0.071809 (rank : 67)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	119	Target Neighborhood Hits	196	Shared Neighborhood Hits	29
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.071564 (rank : 68)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	119	Target Neighborhood Hits	198	Shared Neighborhood Hits	27
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

EPAS1_MOUSE
NC score	0.071256 (rank : 69)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	119	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
NC score	0.069185 (rank : 70)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	119	Target Neighborhood Hits	118	Shared Neighborhood Hits	14
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.068444 (rank : 71)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	119	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

AHR_HUMAN
NC score	0.067217 (rank : 72)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	119	Target Neighborhood Hits	47	Shared Neighborhood Hits	16
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

HES2_MOUSE
NC score	0.065651 (rank : 73)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	119	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

SIM2_HUMAN
NC score	0.065537 (rank : 74)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	119	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

XE7_HUMAN
NC score	0.065169 (rank : 75)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	119	Target Neighborhood Hits	738	Shared Neighborhood Hits	24
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

SIM2_MOUSE
NC score	0.064469 (rank : 76)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	119	Target Neighborhood Hits	75	Shared Neighborhood Hits	17
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

SIM1_MOUSE
NC score	0.064370 (rank : 77)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	119	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.064258 (rank : 78)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	119	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

TAL1_HUMAN
NC score	0.064078 (rank : 79)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	119	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

PALM_MOUSE
NC score	0.064052 (rank : 80)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	119	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Z0P4, Q9Z0P3	Gene names	Palm
Domain Architecture
Description	Paralemmin.

RNC_HUMAN
NC score	0.063465 (rank : 81)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	119	Target Neighborhood Hits	176	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

HES2_HUMAN
NC score	0.062755 (rank : 82)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

TAL1_MOUSE
NC score	0.062188 (rank : 83)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	119	Target Neighborhood Hits	110	Shared Neighborhood Hits	24
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

NPAS1_HUMAN
NC score	0.061330 (rank : 84)	θ value	6.88961 (rank : 98)
Query Neighborhood Hits	119	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS3_MOUSE
NC score	0.061076 (rank : 85)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	119	Target Neighborhood Hits	103	Shared Neighborhood Hits	15
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.059686 (rank : 86)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	119	Target Neighborhood Hits	81	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

HES3_MOUSE
NC score	0.058970 (rank : 87)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	119	Target Neighborhood Hits	38	Shared Neighborhood Hits	20
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

AHR_MOUSE
NC score	0.057871 (rank : 88)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	119	Target Neighborhood Hits	55	Shared Neighborhood Hits	11
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

MYCB_MOUSE
NC score	0.056647 (rank : 89)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	119	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

NPAS1_MOUSE
NC score	0.055388 (rank : 90)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	119	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NCOA3_HUMAN
NC score	0.054129 (rank : 91)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	119	Target Neighborhood Hits	171	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PER2_MOUSE
NC score	0.052992 (rank : 92)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	119	Target Neighborhood Hits	325	Shared Neighborhood Hits	19
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER1_MOUSE
NC score	0.050679 (rank : 93)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	119	Target Neighborhood Hits	235	Shared Neighborhood Hits	24
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

SOX5_HUMAN
NC score	0.041736 (rank : 94)	θ value	0.163984 (rank : 34)
Query Neighborhood Hits	119	Target Neighborhood Hits	219	Shared Neighborhood Hits	12
SwissProt Accessions	P35711, Q86UK8, Q8J017, Q8J018, Q8J019, Q8J020, Q8N1D9, Q8N7E0, Q8TEA4	Gene names	SOX5
Domain Architecture
Description	Transcription factor SOX-5.

NDF1_MOUSE
NC score	0.039935 (rank : 95)	θ value	0.125558 (rank : 31)
Query Neighborhood Hits	119	Target Neighborhood Hits	209	Shared Neighborhood Hits	17
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NDF1_HUMAN
NC score	0.034979 (rank : 96)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	119	Target Neighborhood Hits	186	Shared Neighborhood Hits	17
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

WWC1_MOUSE
NC score	0.034850 (rank : 97)	θ value	1.38821 (rank : 57)
Query Neighborhood Hits	119	Target Neighborhood Hits	290	Shared Neighborhood Hits	14
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

SOX9_HUMAN
NC score	0.034379 (rank : 98)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	119	Target Neighborhood Hits	210	Shared Neighborhood Hits	11
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

NCOA6_MOUSE
NC score	0.033363 (rank : 99)	θ value	2.36792 (rank : 60)
Query Neighborhood Hits	119	Target Neighborhood Hits	1076	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NCOA6_HUMAN
NC score	0.031970 (rank : 100)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	119	Target Neighborhood Hits	1202	Shared Neighborhood Hits	26
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ITF2_HUMAN
NC score	0.031232 (rank : 101)	θ value	5.27518 (rank : 82)
Query Neighborhood Hits	119	Target Neighborhood Hits	168	Shared Neighborhood Hits	14
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

SOX9_MOUSE
NC score	0.031191 (rank : 102)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	119	Target Neighborhood Hits	188	Shared Neighborhood Hits	10
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

IF140_HUMAN
NC score	0.031018 (rank : 103)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RY7, O60332	Gene names	IFT140, KIAA0590, WDTC2
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 140 homolog (WD and tetratricopeptide repeats protein 2).

SNPC4_MOUSE
NC score	0.030971 (rank : 104)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	119	Target Neighborhood Hits	237	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

JUN_MOUSE
NC score	0.028250 (rank : 105)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	119	Target Neighborhood Hits	145	Shared Neighborhood Hits	7
SwissProt Accessions	P05627	Gene names	Jun
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (Jun A) (AH119).

PSCBP_HUMAN
NC score	0.028222 (rank : 106)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	119	Target Neighborhood Hits	123	Shared Neighborhood Hits	3
SwissProt Accessions	O60759, Q15630, Q8NE32	Gene names	PSCDBP, CYTIP
Domain Architecture	No domain graphic available
Description	Pleckstrin homology Sec7 and coiled-coil domains-binding protein (Cytohesin-binding protein HE) (CYBR) (Cytohesin binder and regulator) (Cytohesin-interacting protein).

BHLH4_MOUSE
NC score	0.027495 (rank : 107)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	119	Target Neighborhood Hits	71	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

IFM2_HUMAN
NC score	0.027091 (rank : 108)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	119	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q01629, Q96DA8	Gene names	IFITM2
Domain Architecture
Description	Interferon-induced transmembrane protein 2 (Interferon-inducible protein 1-8D).

BCL9_MOUSE
NC score	0.027057 (rank : 109)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	119	Target Neighborhood Hits	770	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BCL9_HUMAN
NC score	0.026677 (rank : 110)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	119	Target Neighborhood Hits	1008	Shared Neighborhood Hits	23
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

JUN_HUMAN
NC score	0.025649 (rank : 111)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	119	Target Neighborhood Hits	144	Shared Neighborhood Hits	8
SwissProt Accessions	P05412, Q96G93	Gene names	JUN
Domain Architecture
Description	Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39).

SON_HUMAN
NC score	0.024447 (rank : 112)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	119	Target Neighborhood Hits	1568	Shared Neighborhood Hits	31
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

RPGR1_MOUSE
NC score	0.022111 (rank : 113)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	119	Target Neighborhood Hits	713	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CS021_HUMAN
NC score	0.022017 (rank : 114)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	119	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IVT2	Gene names	C19orf21
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf21.

HGS_HUMAN
NC score	0.021251 (rank : 115)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	119	Target Neighborhood Hits	517	Shared Neighborhood Hits	20
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

TXND2_HUMAN
NC score	0.020906 (rank : 116)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	119	Target Neighborhood Hits	793	Shared Neighborhood Hits	14
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

CCD41_HUMAN
NC score	0.020421 (rank : 117)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	119	Target Neighborhood Hits	1139	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

FYCO1_MOUSE
NC score	0.019666 (rank : 118)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	119	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

HGS_MOUSE
NC score	0.019337 (rank : 119)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	119	Target Neighborhood Hits	589	Shared Neighborhood Hits	20
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

FYCO1_HUMAN
NC score	0.019011 (rank : 120)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	119	Target Neighborhood Hits	1149	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

TRAIP_MOUSE
NC score	0.018242 (rank : 121)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	119	Target Neighborhood Hits	745	Shared Neighborhood Hits	22
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

MLL3_HUMAN
NC score	0.016777 (rank : 122)	θ value	5.27518 (rank : 83)
Query Neighborhood Hits	119	Target Neighborhood Hits	1644	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MKL1_MOUSE
NC score	0.016576 (rank : 123)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	119	Target Neighborhood Hits	667	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

THOC2_HUMAN
NC score	0.016575 (rank : 124)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	119	Target Neighborhood Hits	337	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NI27, Q9H8I6	Gene names	THOC2, CXorf3
Domain Architecture	No domain graphic available
Description	THO complex subunit 2 (Tho2).

MYH9_HUMAN
NC score	0.016574 (rank : 125)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	119	Target Neighborhood Hits	1762	Shared Neighborhood Hits	44
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RIOK2_HUMAN
NC score	0.015918 (rank : 126)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	119	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BVS4, Q9NUT0	Gene names	RIOK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

CCD41_MOUSE
NC score	0.015365 (rank : 127)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	119	Target Neighborhood Hits	1399	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

HIP1R_HUMAN
NC score	0.015345 (rank : 128)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	119	Target Neighborhood Hits	809	Shared Neighborhood Hits	19
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HSPB8_MOUSE
NC score	0.014290 (rank : 129)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	119	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JK92	Gene names	Hspb8, Cryac, Hsp22
Domain Architecture
Description	Heat-shock protein beta-8 (HspB8) (Alpha crystallin C chain) (Small stress protein-like protein HSP22).

SPC24_HUMAN
NC score	0.013827 (rank : 130)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	119	Target Neighborhood Hits	324	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

NIN_HUMAN
NC score	0.013724 (rank : 131)	θ value	6.88961 (rank : 97)
Query Neighborhood Hits	119	Target Neighborhood Hits	1416	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

CASP_HUMAN
NC score	0.012976 (rank : 132)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	119	Target Neighborhood Hits	1131	Shared Neighborhood Hits	27
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CK035_HUMAN
NC score	0.012858 (rank : 133)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	119	Target Neighborhood Hits	149	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IXW0	Gene names	C11orf35
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf35.

AKAP9_HUMAN
NC score	0.012791 (rank : 134)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	119	Target Neighborhood Hits	1710	Shared Neighborhood Hits	33
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

LAMA1_MOUSE
NC score	0.012677 (rank : 135)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	119	Target Neighborhood Hits	838	Shared Neighborhood Hits	16
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

GCC2_MOUSE
NC score	0.012333 (rank : 136)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	119	Target Neighborhood Hits	1619	Shared Neighborhood Hits	29
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

STX7_HUMAN
NC score	0.011793 (rank : 137)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	119	Target Neighborhood Hits	111	Shared Neighborhood Hits	7
SwissProt Accessions	O15400, Q5SZW2, Q96ES9	Gene names	STX7
Domain Architecture
Description	Syntaxin-7.

MYO5C_HUMAN
NC score	0.010356 (rank : 138)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	119	Target Neighborhood Hits	1206	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

CAC1S_MOUSE
NC score	0.010164 (rank : 139)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	119	Target Neighborhood Hits	98	Shared Neighborhood Hits	3
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

LIFR_MOUSE
NC score	0.009575 (rank : 140)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	119	Target Neighborhood Hits	127	Shared Neighborhood Hits	3
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

CAC1S_HUMAN
NC score	0.009469 (rank : 141)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	119	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

DMD_HUMAN
NC score	0.009447 (rank : 142)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	119	Target Neighborhood Hits	1135	Shared Neighborhood Hits	19
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

FXR1_MOUSE
NC score	0.006933 (rank : 143)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	119	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q61584, Q8VCU4, Q9R1E2, Q9R1E3, Q9R1E4, Q9R1E5, Q9WUA7, Q9WUA8, Q9WUA9	Gene names	Fxr1, Fxr1h
Domain Architecture
Description	Fragile X mental retardation syndrome-related protein 1 (mFxr1p).

GRB10_MOUSE
NC score	0.006847 (rank : 144)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	119	Target Neighborhood Hits	156	Shared Neighborhood Hits	3
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

E2F2_MOUSE
NC score	0.006650 (rank : 145)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	119	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P56931, Q8BID0	Gene names	E2f2
Domain Architecture	No domain graphic available
Description	Transcription factor E2F2 (E2F-2).

MRCKB_MOUSE
NC score	0.005842 (rank : 146)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	119	Target Neighborhood Hits	2180	Shared Neighborhood Hits	28
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TNIK_HUMAN
NC score	0.005658 (rank : 147)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	119	Target Neighborhood Hits	1570	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

FOXN1_MOUSE
NC score	0.004673 (rank : 148)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	119	Target Neighborhood Hits	300	Shared Neighborhood Hits	4
SwissProt Accessions	Q61575	Gene names	Foxn1, Fkh19, Hfh11, Whn
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/forkhead homolog 11) (HFH-11).

PGCA_HUMAN
NC score	0.004399 (rank : 149)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	119	Target Neighborhood Hits	821	Shared Neighborhood Hits	9
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

OBSCN_HUMAN
NC score	-0.001817 (rank : 150)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	119	Target Neighborhood Hits	1931	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).