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Network neighborhood for query Sequence : SIM1_MOUSE

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SIM1_MOUSE
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SIM1_HUMAN
θ value	0 (rank : 1)	NC score	0.998753 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	62	Shared Neighborhood Hits	56
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	0 (rank : 3)	NC score	0.988506 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	0 (rank : 4)	NC score	0.987324 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	75	Shared Neighborhood Hits	40
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS3_MOUSE
θ value	1.65806e-78 (rank : 5)	NC score	0.937034 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
θ value	2.1655e-78 (rank : 6)	NC score	0.938104 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
θ value	4.99229e-75 (rank : 7)	NC score	0.947077 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
θ value	1.04096e-72 (rank : 8)	NC score	0.945290 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

HIF1A_MOUSE
θ value	1.7756e-72 (rank : 9)	NC score	0.932898 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
θ value	5.1662e-72 (rank : 10)	NC score	0.929965 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_MOUSE
θ value	3.35642e-63 (rank : 11)	NC score	0.920668 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

EPAS1_HUMAN
θ value	9.76566e-63 (rank : 12)	NC score	0.921283 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

BMAL1_MOUSE
θ value	1.6813e-30 (rank : 13)	NC score	0.797677 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	121	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
θ value	4.89182e-30 (rank : 14)	NC score	0.799101 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	43
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

AHR_MOUSE
θ value	1.08979e-29 (rank : 15)	NC score	0.834025 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_HUMAN
θ value	5.97985e-28 (rank : 16)	NC score	0.834601 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

ARNT2_HUMAN
θ value	1.80048e-24 (rank : 17)	NC score	0.752354 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	5.23862e-24 (rank : 18)	NC score	0.750912 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

CLOCK_HUMAN
θ value	1.16704e-23 (rank : 19)	NC score	0.763848 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	1.99067e-23 (rank : 20)	NC score	0.761162 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT_HUMAN
θ value	1.29031e-22 (rank : 21)	NC score	0.740924 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.6852e-22 (rank : 22)	NC score	0.728266 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	213	Shared Neighborhood Hits	43
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
θ value	7.82807e-20 (rank : 23)	NC score	0.692197 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS2_MOUSE
θ value	2.27762e-19 (rank : 24)	NC score	0.739351 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS4_MOUSE
θ value	8.65492e-19 (rank : 25)	NC score	0.676622 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	245	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NPAS2_HUMAN
θ value	1.13037e-18 (rank : 26)	NC score	0.731920 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NCOA1_MOUSE
θ value	3.28887e-18 (rank : 27)	NC score	0.641130 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	196	Shared Neighborhood Hits	40
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	7.32683e-18 (rank : 28)	NC score	0.637614 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
θ value	2.43908e-13 (rank : 29)	NC score	0.565755 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	1.2105e-12 (rank : 30)	NC score	0.563301 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
θ value	4.30538e-10 (rank : 31)	NC score	0.561427 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	171	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
θ value	4.0297e-08 (rank : 32)	NC score	0.524071 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	203	Shared Neighborhood Hits	35
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER2_HUMAN
θ value	0.00134147 (rank : 33)	NC score	0.253722 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	0.00869519 (rank : 34)	NC score	0.231877 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.261653 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

M3K3_MOUSE
θ value	0.21417 (rank : 36)	NC score	-0.000778 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	876	Shared Neighborhood Hits	5
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

TREF1_MOUSE
θ value	0.21417 (rank : 37)	NC score	0.024971 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

KIF17_MOUSE
θ value	0.279714 (rank : 38)	NC score	0.007398 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

MAGC1_HUMAN
θ value	0.279714 (rank : 39)	NC score	0.032969 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

AREG_MOUSE
θ value	0.365318 (rank : 40)	NC score	0.040441 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

PER1_HUMAN
θ value	0.365318 (rank : 41)	NC score	0.237752 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	215	Shared Neighborhood Hits	28
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	0.62314 (rank : 42)	NC score	0.233710 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	28
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.231367 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	34
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

FILA_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.019740 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	685	Shared Neighborhood Hits	11
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

PPRB_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.027020 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	354	Shared Neighborhood Hits	14
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

TP53B_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.019247 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	413	Shared Neighborhood Hits	4
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

3BHS5_MOUSE
θ value	2.36792 (rank : 47)	NC score	0.007556 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q61694, Q91X27	Gene names	Hsd3b5
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 5 (3 beta-hydroxysteroid dehydrogenase type V) (3Beta-HSD V) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

ZN174_HUMAN
θ value	2.36792 (rank : 48)	NC score	-0.002198 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

BCLF1_MOUSE
θ value	3.0926 (rank : 49)	NC score	0.020477 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	303	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

PDE4C_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.005947 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

ELOA1_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.011300 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	388	Shared Neighborhood Hits	8
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

HEY1_HUMAN
θ value	4.03905 (rank : 52)	NC score	0.099057 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.102816 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.109242 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.107336 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

PTN21_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.002002 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

HELI_MOUSE
θ value	5.27518 (rank : 57)	NC score	-0.003181 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	746	Shared Neighborhood Hits	4
SwissProt Accessions	P81183	Gene names	Ikzf2, Helios, Zfpn1a2, Znfn1a2
Domain Architecture	No domain graphic available
Description	Zinc finger protein Helios (IKAROS family zinc finger protein 2).

NCOR2_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.011286 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	790	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

PITM2_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.009303 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

TNAP2_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.015036 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q61333, Q922G1	Gene names	Tnfaip2
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 2 (Primary response gene B94 protein).

CENPJ_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.006954 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	721	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

MAGI1_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.001632 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	403	Shared Neighborhood Hits	6
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

PRIC1_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.004431 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

RBNS5_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.011904 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

TAF1C_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.016459 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDZ2, P97359, Q3U3B6, Q8BN54	Gene names	Taf1c
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor, RNA polymerase I, subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 95 kDa) (TAFI95).

HES5_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.070877 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

M4K4_HUMAN
θ value	8.99809 (rank : 67)	NC score	-0.004448 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	1589	Shared Neighborhood Hits	7
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PP1RB_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.011891 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O60927	Gene names	PPP1R11, HCGV
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 11 (Protein phosphatase inhibitor 3) (Hemochromatosis candidate protein V) (HCG V) (HCG-V).

SRRM2_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.022915 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	1296	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

MITF_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.068444 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.070005 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.063885 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.063902 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TCFL5_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.069764 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

TFE3_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.068395 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	190	Shared Neighborhood Hits	16
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.064414 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.064370 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	119	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.064106 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.064077 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.061810 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.057788 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

SIM1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	69
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.998753 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	69	Target Neighborhood Hits	62	Shared Neighborhood Hits	56
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM2_HUMAN
NC score	0.988506 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	69	Target Neighborhood Hits	76	Shared Neighborhood Hits	42
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.987324 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	69	Target Neighborhood Hits	75	Shared Neighborhood Hits	40
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

NPAS1_MOUSE
NC score	0.947077 (rank : 5)	θ value	4.99229e-75 (rank : 7)
Query Neighborhood Hits	69	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.945290 (rank : 6)	θ value	1.04096e-72 (rank : 8)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	32
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS3_HUMAN
NC score	0.938104 (rank : 7)	θ value	2.1655e-78 (rank : 6)
Query Neighborhood Hits	69	Target Neighborhood Hits	81	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
NC score	0.937034 (rank : 8)	θ value	1.65806e-78 (rank : 5)
Query Neighborhood Hits	69	Target Neighborhood Hits	103	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

HIF1A_MOUSE
NC score	0.932898 (rank : 9)	θ value	1.7756e-72 (rank : 9)
Query Neighborhood Hits	69	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

HIF1A_HUMAN
NC score	0.929965 (rank : 10)	θ value	5.1662e-72 (rank : 10)
Query Neighborhood Hits	69	Target Neighborhood Hits	118	Shared Neighborhood Hits	41
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

EPAS1_HUMAN
NC score	0.921283 (rank : 11)	θ value	9.76566e-63 (rank : 12)
Query Neighborhood Hits	69	Target Neighborhood Hits	76	Shared Neighborhood Hits	39
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.920668 (rank : 12)	θ value	3.35642e-63 (rank : 11)
Query Neighborhood Hits	69	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

AHR_HUMAN
NC score	0.834601 (rank : 13)	θ value	5.97985e-28 (rank : 16)
Query Neighborhood Hits	69	Target Neighborhood Hits	47	Shared Neighborhood Hits	33
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.834025 (rank : 14)	θ value	1.08979e-29 (rank : 15)
Query Neighborhood Hits	69	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

BMAL1_HUMAN
NC score	0.799101 (rank : 15)	θ value	4.89182e-30 (rank : 14)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	43
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.797677 (rank : 16)	θ value	1.6813e-30 (rank : 13)
Query Neighborhood Hits	69	Target Neighborhood Hits	121	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

CLOCK_HUMAN
NC score	0.763848 (rank : 17)	θ value	1.16704e-23 (rank : 19)
Query Neighborhood Hits	69	Target Neighborhood Hits	127	Shared Neighborhood Hits	43
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.761162 (rank : 18)	θ value	1.99067e-23 (rank : 20)
Query Neighborhood Hits	69	Target Neighborhood Hits	148	Shared Neighborhood Hits	43
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

ARNT2_HUMAN
NC score	0.752354 (rank : 19)	θ value	1.80048e-24 (rank : 17)
Query Neighborhood Hits	69	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
NC score	0.750912 (rank : 20)	θ value	5.23862e-24 (rank : 18)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.740924 (rank : 21)	θ value	1.29031e-22 (rank : 21)
Query Neighborhood Hits	69	Target Neighborhood Hits	109	Shared Neighborhood Hits	42
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS2_MOUSE
NC score	0.739351 (rank : 22)	θ value	2.27762e-19 (rank : 24)
Query Neighborhood Hits	69	Target Neighborhood Hits	132	Shared Neighborhood Hits	41
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.731920 (rank : 23)	θ value	1.13037e-18 (rank : 26)
Query Neighborhood Hits	69	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

ARNT_MOUSE
NC score	0.728266 (rank : 24)	θ value	1.6852e-22 (rank : 22)
Query Neighborhood Hits	69	Target Neighborhood Hits	213	Shared Neighborhood Hits	43
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NPAS4_HUMAN
NC score	0.692197 (rank : 25)	θ value	7.82807e-20 (rank : 23)
Query Neighborhood Hits	69	Target Neighborhood Hits	214	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.676622 (rank : 26)	θ value	8.65492e-19 (rank : 25)
Query Neighborhood Hits	69	Target Neighborhood Hits	245	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NCOA1_MOUSE
NC score	0.641130 (rank : 27)	θ value	3.28887e-18 (rank : 27)
Query Neighborhood Hits	69	Target Neighborhood Hits	196	Shared Neighborhood Hits	40
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.637614 (rank : 28)	θ value	7.32683e-18 (rank : 28)
Query Neighborhood Hits	69	Target Neighborhood Hits	198	Shared Neighborhood Hits	40
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
NC score	0.565755 (rank : 29)	θ value	2.43908e-13 (rank : 29)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	36
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
NC score	0.563301 (rank : 30)	θ value	1.2105e-12 (rank : 30)
Query Neighborhood Hits	69	Target Neighborhood Hits	281	Shared Neighborhood Hits	35
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_HUMAN
NC score	0.561427 (rank : 31)	θ value	4.30538e-10 (rank : 31)
Query Neighborhood Hits	69	Target Neighborhood Hits	171	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA3_MOUSE
NC score	0.524071 (rank : 32)	θ value	4.0297e-08 (rank : 32)
Query Neighborhood Hits	69	Target Neighborhood Hits	203	Shared Neighborhood Hits	35
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PER3_MOUSE
NC score	0.261653 (rank : 33)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	69	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.253722 (rank : 34)	θ value	0.00134147 (rank : 33)
Query Neighborhood Hits	69	Target Neighborhood Hits	170	Shared Neighborhood Hits	27
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.237752 (rank : 35)	θ value	0.365318 (rank : 41)
Query Neighborhood Hits	69	Target Neighborhood Hits	215	Shared Neighborhood Hits	28
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.233710 (rank : 36)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	69	Target Neighborhood Hits	235	Shared Neighborhood Hits	28
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER2_MOUSE
NC score	0.231877 (rank : 37)	θ value	0.00869519 (rank : 34)
Query Neighborhood Hits	69	Target Neighborhood Hits	325	Shared Neighborhood Hits	25
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
NC score	0.231367 (rank : 38)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	69	Target Neighborhood Hits	479	Shared Neighborhood Hits	34
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

HEY2_HUMAN
NC score	0.109242 (rank : 39)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	69	Target Neighborhood Hits	77	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.107336 (rank : 40)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	69	Target Neighborhood Hits	80	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_MOUSE
NC score	0.102816 (rank : 41)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	69	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.099057 (rank : 42)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	69	Target Neighborhood Hits	82	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES5_MOUSE
NC score	0.070877 (rank : 43)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	69	Target Neighborhood Hits	38	Shared Neighborhood Hits	17
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MITF_MOUSE
NC score	0.070005 (rank : 44)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	69	Target Neighborhood Hits	115	Shared Neighborhood Hits	17
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TCFL5_HUMAN
NC score	0.069764 (rank : 45)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	69	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MITF_HUMAN
NC score	0.068444 (rank : 46)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	69	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
NC score	0.068395 (rank : 47)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	69	Target Neighborhood Hits	190	Shared Neighborhood Hits	16
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
NC score	0.064414 (rank : 48)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	69	Target Neighborhood Hits	111	Shared Neighborhood Hits	15
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
NC score	0.064370 (rank : 49)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	69	Target Neighborhood Hits	119	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
NC score	0.064106 (rank : 50)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	69	Target Neighborhood Hits	70	Shared Neighborhood Hits	13
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.064077 (rank : 51)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	69	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MLX_MOUSE
NC score	0.063902 (rank : 52)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	69	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.063885 (rank : 53)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	69	Target Neighborhood Hits	95	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF2_HUMAN
NC score	0.061810 (rank : 54)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	69	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.057788 (rank : 55)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	69	Target Neighborhood Hits	173	Shared Neighborhood Hits	13
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

AREG_MOUSE
NC score	0.040441 (rank : 56)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	69	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	P31955	Gene names	Areg, Sdgf
Domain Architecture	No domain graphic available
Description	Amphiregulin precursor (AR) (Schwannoma-derived growth factor) (SDGF).

MAGC1_HUMAN
NC score	0.032969 (rank : 57)	θ value	0.279714 (rank : 39)
Query Neighborhood Hits	69	Target Neighborhood Hits	431	Shared Neighborhood Hits	16
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

PPRB_MOUSE
NC score	0.027020 (rank : 58)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	69	Target Neighborhood Hits	354	Shared Neighborhood Hits	14
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

TREF1_MOUSE
NC score	0.024971 (rank : 59)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	69	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

SRRM2_HUMAN
NC score	0.022915 (rank : 60)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	69	Target Neighborhood Hits	1296	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

BCLF1_MOUSE
NC score	0.020477 (rank : 61)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	69	Target Neighborhood Hits	303	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K019, Q8BNZ0, Q8C2E9, Q9CSW5	Gene names	Bclaf1, Btf, Kiaa0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

FILA_HUMAN
NC score	0.019740 (rank : 62)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	69	Target Neighborhood Hits	685	Shared Neighborhood Hits	11
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

TP53B_HUMAN
NC score	0.019247 (rank : 63)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	69	Target Neighborhood Hits	413	Shared Neighborhood Hits	4
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TAF1C_MOUSE
NC score	0.016459 (rank : 64)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	69	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDZ2, P97359, Q3U3B6, Q8BN54	Gene names	Taf1c
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor, RNA polymerase I, subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 95 kDa) (TAFI95).

TNAP2_MOUSE
NC score	0.015036 (rank : 65)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	69	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q61333, Q922G1	Gene names	Tnfaip2
Domain Architecture
Description	Tumor necrosis factor, alpha-induced protein 2 (Primary response gene B94 protein).

RBNS5_HUMAN
NC score	0.011904 (rank : 66)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	69	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

PP1RB_HUMAN
NC score	0.011891 (rank : 67)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	69	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O60927	Gene names	PPP1R11, HCGV
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 11 (Protein phosphatase inhibitor 3) (Hemochromatosis candidate protein V) (HCG V) (HCG-V).

ELOA1_HUMAN
NC score	0.011300 (rank : 68)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	69	Target Neighborhood Hits	388	Shared Neighborhood Hits	8
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

NCOR2_MOUSE
NC score	0.011286 (rank : 69)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	69	Target Neighborhood Hits	790	Shared Neighborhood Hits	10
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

PITM2_HUMAN
NC score	0.009303 (rank : 70)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	69	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BZ72, Q9P271	Gene names	PITPNM2, KIAA1457, NIR3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3).

3BHS5_MOUSE
NC score	0.007556 (rank : 71)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	69	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q61694, Q91X27	Gene names	Hsd3b5
Domain Architecture
Description	3 beta-hydroxysteroid dehydrogenase type 5 (3 beta-hydroxysteroid dehydrogenase type V) (3Beta-HSD V) (NADPH-dependent 3-beta-hydroxy- delta(5)-steroid dehydrogenase) (EC 1.1.1.-) (3-beta-hydroxy-5-ene steroid dehydrogenase) (Progesterone reductase).

KIF17_MOUSE
NC score	0.007398 (rank : 72)	θ value	0.279714 (rank : 38)
Query Neighborhood Hits	69	Target Neighborhood Hits	452	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

CENPJ_HUMAN
NC score	0.006954 (rank : 73)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	69	Target Neighborhood Hits	721	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

PDE4C_HUMAN
NC score	0.005947 (rank : 74)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	69	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PRIC1_HUMAN
NC score	0.004431 (rank : 75)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	69	Target Neighborhood Hits	187	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MT3, Q71QF8, Q96N00	Gene names	PRICKLE1, RILP
Domain Architecture	No domain graphic available
Description	Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1).

PTN21_HUMAN
NC score	0.002002 (rank : 76)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	69	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	Q16825	Gene names	PTPN21, PTPD1
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 21 (EC 3.1.3.48) (Protein-tyrosine phosphatase D1).

MAGI1_MOUSE
NC score	0.001632 (rank : 77)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	69	Target Neighborhood Hits	403	Shared Neighborhood Hits	6
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

M3K3_MOUSE
NC score	-0.000778 (rank : 78)	θ value	0.21417 (rank : 36)
Query Neighborhood Hits	69	Target Neighborhood Hits	876	Shared Neighborhood Hits	5
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

ZN174_HUMAN
NC score	-0.002198 (rank : 79)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	69	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q15697, Q9BQ34	Gene names	ZNF174, ZSCAN8
Domain Architecture
Description	Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8).

HELI_MOUSE
NC score	-0.003181 (rank : 80)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	69	Target Neighborhood Hits	746	Shared Neighborhood Hits	4
SwissProt Accessions	P81183	Gene names	Ikzf2, Helios, Zfpn1a2, Znfn1a2
Domain Architecture	No domain graphic available
Description	Zinc finger protein Helios (IKAROS family zinc finger protein 2).

M4K4_HUMAN
NC score	-0.004448 (rank : 81)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	69	Target Neighborhood Hits	1589	Shared Neighborhood Hits	7
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).