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Network neighborhood for query Sequence : SYM_HUMAN

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SYM_HUMAN
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYM_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYM_MOUSE
θ value	0 (rank : 2)	NC score	0.990328 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYMM_MOUSE
θ value	8.3442e-30 (rank : 3)	NC score	0.666158 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYMM_HUMAN
θ value	5.40856e-29 (rank : 4)	NC score	0.663062 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYEP_MOUSE
θ value	1.09739e-05 (rank : 5)	NC score	0.221719 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SYEP_HUMAN
θ value	5.44631e-05 (rank : 6)	NC score	0.213020 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SYH_MOUSE
θ value	0.00175202 (rank : 7)	NC score	0.159667 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYH_HUMAN
θ value	0.00509761 (rank : 8)	NC score	0.150490 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYLM_HUMAN
θ value	0.0252991 (rank : 9)	NC score	0.130559 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q15031	Gene names	LARS2, KIAA0028
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYW_HUMAN
θ value	0.0252991 (rank : 10)	NC score	0.144055 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

SYLM_MOUSE
θ value	0.0330416 (rank : 11)	NC score	0.129150 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDC0	Gene names	Lars2
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYV_HUMAN
θ value	0.0431538 (rank : 12)	NC score	0.146858 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYW_MOUSE
θ value	0.125558 (rank : 13)	NC score	0.140491 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P32921, Q80ZY4, Q99J58, Q9DC65	Gene names	Wars, Wrs
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS).

SYIM_MOUSE
θ value	0.21417 (rank : 14)	NC score	0.123585 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

EF1G_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.102626 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196	Gene names	EEF1G, EF1G
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

ACTN4_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.037785 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

EF1G_MOUSE
θ value	0.62314 (rank : 17)	NC score	0.094781 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D8N0, Q920C5, Q9CRT5, Q9CSU3, Q9D004	Gene names	Eef1g
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

NEP_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.035182 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

SYV_MOUSE
θ value	0.813845 (rank : 19)	NC score	0.151583 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1Q9, Q9QUN2	Gene names	Vars, Bat6, G7a, Vars2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

ACTN4_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.034994 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	276	Shared Neighborhood Hits	9
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

S12A5_HUMAN
θ value	1.38821 (rank : 21)	NC score	0.022654 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

S12A5_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.022664 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

NEP_MOUSE
θ value	1.81305 (rank : 23)	NC score	0.025043 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

SYIM_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.110915 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSE4, Q6PI85, Q7L439, Q86WU9, Q96D91	Gene names	IARS2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

MCA3_MOUSE
θ value	2.36792 (rank : 25)	NC score	0.088543 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D1M4	Gene names	Eef1e1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYIC_MOUSE
θ value	2.36792 (rank : 26)	NC score	0.089957 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BU30	Gene names	Iars
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

ACTN1_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.031464 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.031551 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

GSTT1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.023289 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P30711, O00226, Q969K8, Q96IY3	Gene names	GSTT1
Domain Architecture
Description	Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1).

SYIC_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.079959 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

GBX1_MOUSE
θ value	5.27518 (rank : 31)	NC score	0.004749 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

ACTN2_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.029438 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

CA065_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.010625 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	469	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

KPCL_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.002165 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	891	Shared Neighborhood Hits	4
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MCA3_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.061038 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	O43324, Q5THS2	Gene names	EEF1E1
Domain Architecture
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

MYO15_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.006236 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	467	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ACTN3_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.028829 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	272	Shared Neighborhood Hits	8
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.028707 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	265	Shared Neighborhood Hits	8
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ISL1_HUMAN
θ value	8.99809 (rank : 39)	NC score	0.005865 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	421	Shared Neighborhood Hits	4
SwissProt Accessions	P61371, P20663, P47894	Gene names	ISL1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

ISL1_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.005865 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	421	Shared Neighborhood Hits	4
SwissProt Accessions	P61372, P20663, P47894, Q812D8	Gene names	Isl1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

KPCL_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.001830 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	887	Shared Neighborhood Hits	4
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

SFR15_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.011432 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SRBP2_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.020410 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SYHH_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.064402 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

SYLC_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.055200 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2J5, Q9NSE1	Gene names	LARS, KIAA1352
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLC_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.053682 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMJ2, Q8BKW9	Gene names	Lars
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYQ_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.073659 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P47897	Gene names	QARS
Domain Architecture
Description	Glutaminyl-tRNA synthetase (EC 6.1.1.18) (Glutamine--tRNA ligase) (GlnRS).

Hits sorted by NC score

SYM_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYM_MOUSE
NC score	0.990328 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	24
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYMM_MOUSE
NC score	0.666158 (rank : 3)	θ value	8.3442e-30 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	28	Shared Neighborhood Hits	12
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYMM_HUMAN
NC score	0.663062 (rank : 4)	θ value	5.40856e-29 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYEP_MOUSE
NC score	0.221719 (rank : 5)	θ value	1.09739e-05 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SYEP_HUMAN
NC score	0.213020 (rank : 6)	θ value	5.44631e-05 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	P07814	Gene names	EPRS, GLNS, PARS, QPRS
Domain Architecture
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

SYH_MOUSE
NC score	0.159667 (rank : 7)	θ value	0.00175202 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYV_MOUSE
NC score	0.151583 (rank : 8)	θ value	0.813845 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z1Q9, Q9QUN2	Gene names	Vars, Bat6, G7a, Vars2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYH_HUMAN
NC score	0.150490 (rank : 9)	θ value	0.00509761 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYV_HUMAN
NC score	0.146858 (rank : 10)	θ value	0.0431538 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	41	Shared Neighborhood Hits	16
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYW_HUMAN
NC score	0.144055 (rank : 11)	θ value	0.0252991 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P23381, P78535, Q9UDL3	Gene names	WARS, WRS
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS) (IFP53) (hWRS).

SYW_MOUSE
NC score	0.140491 (rank : 12)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	P32921, Q80ZY4, Q99J58, Q9DC65	Gene names	Wars, Wrs
Domain Architecture
Description	Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan--tRNA ligase) (TrpRS).

SYLM_HUMAN
NC score	0.130559 (rank : 13)	θ value	0.0252991 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q15031	Gene names	LARS2, KIAA0028
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLM_MOUSE
NC score	0.129150 (rank : 14)	θ value	0.0330416 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q8VDC0	Gene names	Lars2
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYIM_MOUSE
NC score	0.123585 (rank : 15)	θ value	0.21417 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYIM_HUMAN
NC score	0.110915 (rank : 16)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSE4, Q6PI85, Q7L439, Q86WU9, Q96D91	Gene names	IARS2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

EF1G_HUMAN
NC score	0.102626 (rank : 17)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	10
SwissProt Accessions	P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196	Gene names	EEF1G, EF1G
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

EF1G_MOUSE
NC score	0.094781 (rank : 18)	θ value	0.62314 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D8N0, Q920C5, Q9CRT5, Q9CSU3, Q9D004	Gene names	Eef1g
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

SYIC_MOUSE
NC score	0.089957 (rank : 19)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BU30	Gene names	Iars
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

MCA3_MOUSE
NC score	0.088543 (rank : 20)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D1M4	Gene names	Eef1e1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYIC_HUMAN
NC score	0.079959 (rank : 21)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	42	Shared Neighborhood Hits	11
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

SYQ_HUMAN
NC score	0.073659 (rank : 22)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	43	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	P47897	Gene names	QARS
Domain Architecture
Description	Glutaminyl-tRNA synthetase (EC 6.1.1.18) (Glutamine--tRNA ligase) (GlnRS).

SYHH_HUMAN
NC score	0.064402 (rank : 23)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	43	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

MCA3_HUMAN
NC score	0.061038 (rank : 24)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	O43324, Q5THS2	Gene names	EEF1E1
Domain Architecture
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYLC_HUMAN
NC score	0.055200 (rank : 25)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	43	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2J5, Q9NSE1	Gene names	LARS, KIAA1352
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLC_MOUSE
NC score	0.053682 (rank : 26)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	43	Target Neighborhood Hits	25	Shared Neighborhood Hits	10
SwissProt Accessions	Q8BMJ2, Q8BKW9	Gene names	Lars
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

ACTN4_HUMAN
NC score	0.037785 (rank : 27)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	279	Shared Neighborhood Hits	9
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

NEP_HUMAN
NC score	0.035182 (rank : 28)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	P08473	Gene names	MME, EPN
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (Common acute lymphocytic leukemia antigen) (CALLA) (CD10 antigen).

ACTN4_MOUSE
NC score	0.034994 (rank : 29)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	276	Shared Neighborhood Hits	9
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

ACTN1_MOUSE
NC score	0.031551 (rank : 30)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_HUMAN
NC score	0.031464 (rank : 31)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN2_MOUSE
NC score	0.029438 (rank : 32)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN3_HUMAN
NC score	0.028829 (rank : 33)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	272	Shared Neighborhood Hits	8
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ACTN3_MOUSE
NC score	0.028707 (rank : 34)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	265	Shared Neighborhood Hits	8
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

NEP_MOUSE
NC score	0.025043 (rank : 35)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

GSTT1_HUMAN
NC score	0.023289 (rank : 36)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P30711, O00226, Q969K8, Q96IY3	Gene names	GSTT1
Domain Architecture
Description	Glutathione S-transferase theta-1 (EC 2.5.1.18) (GST class-theta-1) (Glutathione transferase T1-1).

S12A5_MOUSE
NC score	0.022664 (rank : 37)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

S12A5_HUMAN
NC score	0.022654 (rank : 38)	θ value	1.38821 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

SRBP2_HUMAN
NC score	0.020410 (rank : 39)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	133	Shared Neighborhood Hits	3
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SFR15_HUMAN
NC score	0.011432 (rank : 40)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	368	Shared Neighborhood Hits	3
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

CA065_HUMAN
NC score	0.010625 (rank : 41)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	469	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

MYO15_MOUSE
NC score	0.006236 (rank : 42)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	467	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

ISL1_HUMAN
NC score	0.005865 (rank : 43)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	421	Shared Neighborhood Hits	4
SwissProt Accessions	P61371, P20663, P47894	Gene names	ISL1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

ISL1_MOUSE
NC score	0.005865 (rank : 44)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	421	Shared Neighborhood Hits	4
SwissProt Accessions	P61372, P20663, P47894, Q812D8	Gene names	Isl1
Domain Architecture
Description	Insulin gene enhancer protein ISL-1 (Islet-1).

GBX1_MOUSE
NC score	0.004749 (rank : 45)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	4
SwissProt Accessions	P82976, Q8CGW5	Gene names	Gbx1
Domain Architecture	No domain graphic available
Description	Homeobox protein GBX-1 (Gastrulation and brain-specific homeobox protein 1).

KPCL_MOUSE
NC score	0.002165 (rank : 46)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	891	Shared Neighborhood Hits	4
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCL_HUMAN
NC score	0.001830 (rank : 47)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	887	Shared Neighborhood Hits	4
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).