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Network neighborhood for query Sequence : SYHH_HUMAN

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SYHH_HUMAN
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYHH_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

SYH_HUMAN
θ value	0 (rank : 2)	NC score	0.990451 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYH_MOUSE
θ value	0 (rank : 3)	NC score	0.983162 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

E2AK4_MOUSE
θ value	7.06379e-29 (rank : 4)	NC score	0.219045 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	984	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

E2AK4_HUMAN
θ value	6.61148e-27 (rank : 5)	NC score	0.212580 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	1012	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

GCN1L_HUMAN
θ value	5.27518 (rank : 6)	NC score	0.019923 (rank : 12)
Query Neighborhood Hits	8	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

MYO5A_HUMAN
θ value	6.88961 (rank : 7)	NC score	0.007832 (rank : 14)
Query Neighborhood Hits	8	Target Neighborhood Hits	1092	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

SKP2_MOUSE
θ value	6.88961 (rank : 8)	NC score	0.012557 (rank : 13)
Query Neighborhood Hits	8	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0Z3, Q8BSG7, Q8C8Y9, Q8CB22, Q99J53	Gene names	Skp2
Domain Architecture
Description	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1).

RNF25_HUMAN
θ value	θ > 10 (rank : 9)	NC score	0.072688 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

RNF25_MOUSE
θ value	θ > 10 (rank : 10)	NC score	0.071267 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

RWDD1_HUMAN
θ value	θ > 10 (rank : 11)	NC score	0.067076 (rank : 9)
Query Neighborhood Hits	8	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H446, Q9Y313, Q9Y6B3	Gene names	RWDD1
Domain Architecture
Description	RWD domain-containing protein 1.

RWDD1_MOUSE
θ value	θ > 10 (rank : 12)	NC score	0.066771 (rank : 10)
Query Neighborhood Hits	8	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQK7	Gene names	Rwdd1
Domain Architecture
Description	RWD domain-containing protein 1 (IH1).

SYM_HUMAN
θ value	θ > 10 (rank : 13)	NC score	0.064402 (rank : 11)
Query Neighborhood Hits	8	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

SYM_MOUSE
θ value	θ > 10 (rank : 14)	NC score	0.073684 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

Hits sorted by NC score

SYHH_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	P49590	Gene names	HARSL, HARSR, HO3
Domain Architecture
Description	Histidyl-tRNA synthetase homolog (EC 6.1.1.21) (Histidine--tRNA ligase homolog) (HisRS).

SYH_HUMAN
NC score	0.990451 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P12081	Gene names	HARS, HRS
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

SYH_MOUSE
NC score	0.983162 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q61035	Gene names	Hars
Domain Architecture
Description	Histidyl-tRNA synthetase (EC 6.1.1.21) (Histidine--tRNA ligase) (HisRS).

E2AK4_MOUSE
NC score	0.219045 (rank : 4)	θ value	7.06379e-29 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	984	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

E2AK4_HUMAN
NC score	0.212580 (rank : 5)	θ value	6.61148e-27 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	1012	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SYM_MOUSE
NC score	0.073684 (rank : 6)	θ value	θ > 10 (rank : 14)
Query Neighborhood Hits	8	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

RNF25_HUMAN
NC score	0.072688 (rank : 7)	θ value	θ > 10 (rank : 9)
Query Neighborhood Hits	8	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q96BH1, Q9H874	Gene names	RNF25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-).

RNF25_MOUSE
NC score	0.071267 (rank : 8)	θ value	θ > 10 (rank : 10)
Query Neighborhood Hits	8	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QZR0, Q3TAL8, Q9DCW7	Gene names	Rnf25
Domain Architecture
Description	RING finger protein 25 (EC 6.3.2.-) (RING finger protein AO7).

RWDD1_HUMAN
NC score	0.067076 (rank : 9)	θ value	θ > 10 (rank : 11)
Query Neighborhood Hits	8	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H446, Q9Y313, Q9Y6B3	Gene names	RWDD1
Domain Architecture
Description	RWD domain-containing protein 1.

RWDD1_MOUSE
NC score	0.066771 (rank : 10)	θ value	θ > 10 (rank : 12)
Query Neighborhood Hits	8	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CQK7	Gene names	Rwdd1
Domain Architecture
Description	RWD domain-containing protein 1 (IH1).

SYM_HUMAN
NC score	0.064402 (rank : 11)	θ value	θ > 10 (rank : 13)
Query Neighborhood Hits	8	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

GCN1L_HUMAN
NC score	0.019923 (rank : 12)	θ value	5.27518 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

SKP2_MOUSE
NC score	0.012557 (rank : 13)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0Z3, Q8BSG7, Q8C8Y9, Q8CB22, Q99J53	Gene names	Skp2
Domain Architecture
Description	S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45) (F-box/WD-40 protein 1) (FWD1).

MYO5A_HUMAN
NC score	0.007832 (rank : 14)	θ value	6.88961 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	1092	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).