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Network neighborhood for query Sequence : S12A5_HUMAN

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S12A5_HUMAN
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

S12A4_HUMAN
θ value	0 (rank : 1)	NC score	0.994714 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UP95, O60632, O75893, Q13953, Q96LD5	Gene names	SLC12A4, KCC1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1).

S12A4_MOUSE
θ value	0 (rank : 2)	NC score	0.994771 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JIS8, O55069, Q9ET57	Gene names	Slc12a4, Kcc1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (mKCC1).

S12A5_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

S12A5_MOUSE
θ value	0 (rank : 4)	NC score	0.998885 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

S12A6_HUMAN
θ value	0 (rank : 5)	NC score	0.993246 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A6_MOUSE
θ value	0 (rank : 6)	NC score	0.993067 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	67	Shared Neighborhood Hits	24
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A7_HUMAN
θ value	0 (rank : 7)	NC score	0.996581 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y666, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2	Gene names	SLC12A7, KCC4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A7_MOUSE
θ value	0 (rank : 8)	NC score	0.996431 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WVL3	Gene names	Slc12a7, Kcc4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A3_MOUSE
θ value	4.22625e-74 (rank : 9)	NC score	0.838752 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P59158	Gene names	Slc12a3, Tsc
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A3_HUMAN
θ value	1.36585e-56 (rank : 10)	NC score	0.820717 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	P55017	Gene names	SLC12A3, TSC
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A2_HUMAN
θ value	5.73848e-55 (rank : 11)	NC score	0.811584 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	P55011, Q8N713, Q8WWH7	Gene names	SLC12A2, NKCC1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A2_MOUSE
θ value	1.2784e-54 (rank : 12)	NC score	0.812458 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	55	Shared Neighborhood Hits	20
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A1_MOUSE
θ value	2.041e-52 (rank : 13)	NC score	0.804343 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	P55014, O35938, Q91W55, Q9Z1E0	Gene names	Slc12a1, Nkcc2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (BSC1) (Kidney-specific Na-K-Cl symporter).

S12A1_HUMAN
θ value	3.48141e-52 (rank : 14)	NC score	0.804567 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q13621	Gene names	SLC12A1, NKCC2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter).

LAT2_HUMAN
θ value	0.000270298 (rank : 15)	NC score	0.122608 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UHI5, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445	Gene names	SLC7A8, LAT2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2).

LAT2_MOUSE
θ value	0.00035302 (rank : 16)	NC score	0.122407 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXW9	Gene names	Slc7a8, Lat2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2).

BAT1_MOUSE
θ value	0.00390308 (rank : 17)	NC score	0.133506 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXA6	Gene names	Slc7a9, Bat1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

CTR1_MOUSE
θ value	0.00869519 (rank : 18)	NC score	0.175881 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	26
SwissProt Accessions	Q09143, P30824	Gene names	Slc7a1, Atrc1, Rec-1
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor) (ERR) (Ecotropic retrovirus receptor).

CTR2_MOUSE
θ value	0.0113563 (rank : 19)	NC score	0.209022 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	P18581	Gene names	Slc7a2, Atrc2, Tea
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (TEA protein) (T-cell early activation protein) (20.5).

BAT1_HUMAN
θ value	0.0148317 (rank : 20)	NC score	0.115754 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	20
SwissProt Accessions	P82251	Gene names	SLC7A9, BAT1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

CTR1_HUMAN
θ value	0.0736092 (rank : 21)	NC score	0.158728 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	P30825	Gene names	SLC7A1, ATRC1, REC1L
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor homolog) (ERR) (Ecotropic retrovirus receptor homolog).

CTR3_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.144789 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	35	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WY07, Q8N185, Q8NCA7, Q96SZ7	Gene names	SLC7A3, ATRC3, CAT3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

OXRP_HUMAN
θ value	0.0736092 (rank : 23)	NC score	0.021370 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	544	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

CTR2_HUMAN
θ value	0.21417 (rank : 24)	NC score	0.185171 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P52569	Gene names	SLC7A2, ATRC2
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2).

CTR4_HUMAN
θ value	0.365318 (rank : 25)	NC score	0.102716 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	O43246, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88	Gene names	SLC7A4
Domain Architecture
Description	Cationic amino acid transporter 4 (CAT-4) (CAT4).

CTR3_MOUSE
θ value	0.47712 (rank : 26)	NC score	0.139303 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

YLA1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.070352 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UM01, O95984, Q9P2V5	Gene names	SLC7A7
Domain Architecture
Description	Y+L amino acid transporter 1 (y(+)L-type amino acid transporter 1) (y+LAT-1) (Y+LAT1) (Monocyte amino acid permease 2) (MOP-2).

SPEG_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.001393 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	1959	Shared Neighborhood Hits	8
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

RTN1_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.021496 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

O1052_MOUSE
θ value	1.38821 (rank : 30)	NC score	0.000746 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	684	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VGR8	Gene names	Olfr1052, Mor172-1
Domain Architecture
Description	Olfactory receptor 1052 (Olfactory receptor 172-1).

SYM_HUMAN
θ value	1.38821 (rank : 31)	NC score	0.022654 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

EVL_HUMAN
θ value	1.81305 (rank : 32)	NC score	0.014658 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

CHIT1_MOUSE
θ value	2.36792 (rank : 33)	NC score	0.007422 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D7Q1, Q6QJD2	Gene names	Chit1
Domain Architecture
Description	Chitotriosidase-1 precursor (EC 3.2.1.14) (Chitinase-1).

MYH10_MOUSE
θ value	2.36792 (rank : 34)	NC score	0.002027 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	1612	Shared Neighborhood Hits	11
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

ADDG_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.010390 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYB5, Q9D2M5, Q9QYB6	Gene names	Add3, Addl
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

MYH10_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.001787 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	1620	Shared Neighborhood Hits	12
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MDN1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.020222 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	662	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

OR5J2_HUMAN
θ value	4.03905 (rank : 38)	NC score	-0.000458 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	649	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NH18, Q6IEU5	Gene names	OR5J2
Domain Architecture
Description	Olfactory receptor 5J2 (Olfactory receptor OR11-266).

ROM1_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.016537 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q03395	Gene names	ROM1, TSPAN23
Domain Architecture
Description	Rod outer segment membrane protein 1 (ROSP1) (Tetraspanin-23) (Tspan- 23).

TRHY_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.001508 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	1385	Shared Neighborhood Hits	11
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ADDB_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.006810 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	574	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

CENPC_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.008781 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	P49452	Gene names	Cenpc1, Cenpc
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C).

CTL4_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.008469 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VA1, Q7TQ02, Q9CVA7	Gene names	Slc44a4, Ctl4, Ng22
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 4 (Solute carrier family 44 member 4).

EDG1_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.005425 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	O08530, Q9R235	Gene names	Edg1, Lpb1
Domain Architecture
Description	Sphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphate receptor 1) (S1P1) (Lysophospholipid receptor B1).

EVL_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.011437 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	203	Shared Neighborhood Hits	5
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

G137B_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.051648 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

TPM4_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.002942 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	703	Shared Neighborhood Hits	7
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

ARI4A_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.006241 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	434	Shared Neighborhood Hits	6
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

EPHA5_HUMAN
θ value	6.88961 (rank : 49)	NC score	-0.001916 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	1009	Shared Neighborhood Hits	6
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	6.88961 (rank : 50)	NC score	-0.001881 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	950	Shared Neighborhood Hits	6
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EYA1_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.004047 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q99502	Gene names	EYA1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

GOGA4_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.006120 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	2034	Shared Neighborhood Hits	15
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GPR84_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.008138 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQS5	Gene names	GPR84, EX33
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33).

IPR1_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.007671 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVK9, Q3UCV7, Q80V00	Gene names	Ipr1, Ifi75
Domain Architecture	No domain graphic available
Description	Intracellular pathogen resistance protein 1.

LPHN1_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.003479 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	4
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).

PP4R1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.006415 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TF05, Q99774, Q9UNQ7	Gene names	PPP4R1, MEG1, PP4R1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

ZN403_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.007934 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3C7, Q96T90, Q9GZR8, Q9H767	Gene names	ZNF403, LCRG1, LZK1
Domain Architecture	No domain graphic available
Description	Protein ZNF403 (Laryngeal carcinoma-related protein 1).

ACOD_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.009450 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O00767, Q16150, Q53GR9, Q5W037, Q5W038, Q6GSS4, Q96KF6, Q9BS07, Q9Y695	Gene names	SCD
Domain Architecture
Description	Acyl-CoA desaturase (EC 1.14.19.1) (Stearoyl-CoA desaturase) (Fatty acid desaturase) (Delta(9)-desaturase).

GPR97_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.003001 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

HYALP_MOUSE
θ value	8.99809 (rank : 60)	NC score	0.006917 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P48794, Q7TSD6, Q812F4, Q9DAQ1	Gene names	Spam1, Ph20, Spam
Domain Architecture
Description	Hyaluronidase PH-20 precursor (EC 3.2.1.35) (Hyal-PH20) (Sperm surface protein PH-20) (Sperm adhesion molecule 1).

MASP2_MOUSE
θ value	8.99809 (rank : 61)	NC score	-0.000761 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

MYO9B_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.002242 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	641	Shared Neighborhood Hits	8
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

OR5K1_HUMAN
θ value	8.99809 (rank : 63)	NC score	-0.001403 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	782	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NHB7	Gene names	OR5K1
Domain Architecture
Description	Olfactory receptor 5K1 (HTPCRX10).

PEG3_MOUSE
θ value	8.99809 (rank : 64)	NC score	-0.002251 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	1101	Shared Neighborhood Hits	8
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).

SPEG_HUMAN
θ value	8.99809 (rank : 65)	NC score	-0.001255 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	1762	Shared Neighborhood Hits	9
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SYF2_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.007800 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	O95926, Q5TH73	Gene names	SYF2, CBPIN, GCIPIP
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29).

TPM4_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.002454 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	525	Shared Neighborhood Hits	6
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

V2R1B_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.004494 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q6TAC4, O70409	Gene names	V2r1b
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor 1b precursor (Putative pheromone receptor V2R1b).

AAA1_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.089411 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NS82	Gene names	SLC7A10, ASC1
Domain Architecture
Description	Asc-type amino acid transporter 1 (Asc-1).

AAA1_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.096175 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P63115, Q9CW25, Q9JMH8	Gene names	Slc7a10, Asc1
Domain Architecture	No domain graphic available
Description	Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter).

LAT1_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.069642 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q01650, Q9UBN8, Q9UP15, Q9UQC0	Gene names	SLC7A5, CD98LC, LAT1, MPE16
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (hLAT1).

LAT1_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.065983 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z127, Q9JMI4	Gene names	Slc7a5, Lat1
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC).

XCT_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.062895 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPY5	Gene names	SLC7A11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT) (Calcium channel blocker resistance protein CCBR1).

XCT_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.068962 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTR6	Gene names	Slc7a11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT).

Hits sorted by NC score

S12A5_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	68	Target Neighborhood Hits	68	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

S12A5_MOUSE
NC score	0.998885 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	68	Target Neighborhood Hits	59	Shared Neighborhood Hits	47
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

S12A7_HUMAN
NC score	0.996581 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y666, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2	Gene names	SLC12A7, KCC4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A7_MOUSE
NC score	0.996431 (rank : 4)	θ value	0 (rank : 8)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WVL3	Gene names	Slc12a7, Kcc4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A4_MOUSE
NC score	0.994771 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JIS8, O55069, Q9ET57	Gene names	Slc12a4, Kcc1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (mKCC1).

S12A4_HUMAN
NC score	0.994714 (rank : 6)	θ value	0 (rank : 1)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UP95, O60632, O75893, Q13953, Q96LD5	Gene names	SLC12A4, KCC1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1).

S12A6_HUMAN
NC score	0.993246 (rank : 7)	θ value	0 (rank : 5)
Query Neighborhood Hits	68	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A6_MOUSE
NC score	0.993067 (rank : 8)	θ value	0 (rank : 6)
Query Neighborhood Hits	68	Target Neighborhood Hits	67	Shared Neighborhood Hits	24
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A3_MOUSE
NC score	0.838752 (rank : 9)	θ value	4.22625e-74 (rank : 9)
Query Neighborhood Hits	68	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	P59158	Gene names	Slc12a3, Tsc
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A3_HUMAN
NC score	0.820717 (rank : 10)	θ value	1.36585e-56 (rank : 10)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	P55017	Gene names	SLC12A3, TSC
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A2_MOUSE
NC score	0.812458 (rank : 11)	θ value	1.2784e-54 (rank : 12)
Query Neighborhood Hits	68	Target Neighborhood Hits	55	Shared Neighborhood Hits	20
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A2_HUMAN
NC score	0.811584 (rank : 12)	θ value	5.73848e-55 (rank : 11)
Query Neighborhood Hits	68	Target Neighborhood Hits	56	Shared Neighborhood Hits	21
SwissProt Accessions	P55011, Q8N713, Q8WWH7	Gene names	SLC12A2, NKCC1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A1_HUMAN
NC score	0.804567 (rank : 13)	θ value	3.48141e-52 (rank : 14)
Query Neighborhood Hits	68	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q13621	Gene names	SLC12A1, NKCC2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter).

S12A1_MOUSE
NC score	0.804343 (rank : 14)	θ value	2.041e-52 (rank : 13)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	19
SwissProt Accessions	P55014, O35938, Q91W55, Q9Z1E0	Gene names	Slc12a1, Nkcc2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (BSC1) (Kidney-specific Na-K-Cl symporter).

CTR2_MOUSE
NC score	0.209022 (rank : 15)	θ value	0.0113563 (rank : 19)
Query Neighborhood Hits	68	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	P18581	Gene names	Slc7a2, Atrc2, Tea
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (TEA protein) (T-cell early activation protein) (20.5).

CTR2_HUMAN
NC score	0.185171 (rank : 16)	θ value	0.21417 (rank : 24)
Query Neighborhood Hits	68	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P52569	Gene names	SLC7A2, ATRC2
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2).

CTR1_MOUSE
NC score	0.175881 (rank : 17)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	26
SwissProt Accessions	Q09143, P30824	Gene names	Slc7a1, Atrc1, Rec-1
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor) (ERR) (Ecotropic retrovirus receptor).

CTR1_HUMAN
NC score	0.158728 (rank : 18)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	68	Target Neighborhood Hits	41	Shared Neighborhood Hits	27
SwissProt Accessions	P30825	Gene names	SLC7A1, ATRC1, REC1L
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor homolog) (ERR) (Ecotropic retrovirus receptor homolog).

CTR3_HUMAN
NC score	0.144789 (rank : 19)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	68	Target Neighborhood Hits	35	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WY07, Q8N185, Q8NCA7, Q96SZ7	Gene names	SLC7A3, ATRC3, CAT3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

CTR3_MOUSE
NC score	0.139303 (rank : 20)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	68	Target Neighborhood Hits	36	Shared Neighborhood Hits	22
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

BAT1_MOUSE
NC score	0.133506 (rank : 21)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QXA6	Gene names	Slc7a9, Bat1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

LAT2_HUMAN
NC score	0.122608 (rank : 22)	θ value	0.000270298 (rank : 15)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UHI5, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445	Gene names	SLC7A8, LAT2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2).

LAT2_MOUSE
NC score	0.122407 (rank : 23)	θ value	0.00035302 (rank : 16)
Query Neighborhood Hits	68	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QXW9	Gene names	Slc7a8, Lat2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2).

BAT1_HUMAN
NC score	0.115754 (rank : 24)	θ value	0.0148317 (rank : 20)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	20
SwissProt Accessions	P82251	Gene names	SLC7A9, BAT1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

CTR4_HUMAN
NC score	0.102716 (rank : 25)	θ value	0.365318 (rank : 25)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	16
SwissProt Accessions	O43246, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88	Gene names	SLC7A4
Domain Architecture
Description	Cationic amino acid transporter 4 (CAT-4) (CAT4).

AAA1_MOUSE
NC score	0.096175 (rank : 26)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	21
SwissProt Accessions	P63115, Q9CW25, Q9JMH8	Gene names	Slc7a10, Asc1
Domain Architecture	No domain graphic available
Description	Asc-type amino acid transporter 1 (Asc-1) (D-serine transporter).

AAA1_HUMAN
NC score	0.089411 (rank : 27)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	68	Target Neighborhood Hits	25	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NS82	Gene names	SLC7A10, ASC1
Domain Architecture
Description	Asc-type amino acid transporter 1 (Asc-1).

YLA1_HUMAN
NC score	0.070352 (rank : 28)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	68	Target Neighborhood Hits	27	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UM01, O95984, Q9P2V5	Gene names	SLC7A7
Domain Architecture
Description	Y+L amino acid transporter 1 (y(+)L-type amino acid transporter 1) (y+LAT-1) (Y+LAT1) (Monocyte amino acid permease 2) (MOP-2).

LAT1_HUMAN
NC score	0.069642 (rank : 29)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	68	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q01650, Q9UBN8, Q9UP15, Q9UQC0	Gene names	SLC7A5, CD98LC, LAT1, MPE16
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (hLAT1).

XCT_MOUSE
NC score	0.068962 (rank : 30)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	68	Target Neighborhood Hits	23	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTR6	Gene names	Slc7a11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT).

LAT1_MOUSE
NC score	0.065983 (rank : 31)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	68	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z127, Q9JMI4	Gene names	Slc7a5, Lat1
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC).

XCT_HUMAN
NC score	0.062895 (rank : 32)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	68	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPY5	Gene names	SLC7A11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT) (Calcium channel blocker resistance protein CCBR1).

G137B_HUMAN
NC score	0.051648 (rank : 33)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	68	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	O60478	Gene names	GPR137B, TM7SF1
Domain Architecture	No domain graphic available
Description	Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1).

SYM_HUMAN
NC score	0.022654 (rank : 34)	θ value	1.38821 (rank : 31)
Query Neighborhood Hits	68	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

RTN1_HUMAN
NC score	0.021496 (rank : 35)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	68	Target Neighborhood Hits	173	Shared Neighborhood Hits	5
SwissProt Accessions	Q16799, Q16800, Q16801	Gene names	RTN1, NSP
Domain Architecture
Description	Reticulon-1 (Neuroendocrine-specific protein).

OXRP_HUMAN
NC score	0.021370 (rank : 36)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	68	Target Neighborhood Hits	544	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

MDN1_HUMAN
NC score	0.020222 (rank : 37)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	68	Target Neighborhood Hits	662	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

ROM1_HUMAN
NC score	0.016537 (rank : 38)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	68	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q03395	Gene names	ROM1, TSPAN23
Domain Architecture
Description	Rod outer segment membrane protein 1 (ROSP1) (Tetraspanin-23) (Tspan- 23).

EVL_HUMAN
NC score	0.014658 (rank : 39)	θ value	1.81305 (rank : 32)
Query Neighborhood Hits	68	Target Neighborhood Hits	260	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EVL_MOUSE
NC score	0.011437 (rank : 40)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	68	Target Neighborhood Hits	203	Shared Neighborhood Hits	5
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

ADDG_MOUSE
NC score	0.010390 (rank : 41)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	68	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QYB5, Q9D2M5, Q9QYB6	Gene names	Add3, Addl
Domain Architecture
Description	Gamma-adducin (Adducin-like protein 70).

ACOD_HUMAN
NC score	0.009450 (rank : 42)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	68	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O00767, Q16150, Q53GR9, Q5W037, Q5W038, Q6GSS4, Q96KF6, Q9BS07, Q9Y695	Gene names	SCD
Domain Architecture
Description	Acyl-CoA desaturase (EC 1.14.19.1) (Stearoyl-CoA desaturase) (Fatty acid desaturase) (Delta(9)-desaturase).

CENPC_MOUSE
NC score	0.008781 (rank : 43)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	68	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	P49452	Gene names	Cenpc1, Cenpc
Domain Architecture	No domain graphic available
Description	Centromere protein C 1 (CENP-C) (Centromere autoantigen C).

CTL4_MOUSE
NC score	0.008469 (rank : 44)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	68	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VA1, Q7TQ02, Q9CVA7	Gene names	Slc44a4, Ctl4, Ng22
Domain Architecture	No domain graphic available
Description	Choline transporter-like protein 4 (Solute carrier family 44 member 4).

GPR84_HUMAN
NC score	0.008138 (rank : 45)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	68	Target Neighborhood Hits	682	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NQS5	Gene names	GPR84, EX33
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 84 (Inflammation-related G-protein coupled receptor EX33).

ZN403_HUMAN
NC score	0.007934 (rank : 46)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	68	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H3C7, Q96T90, Q9GZR8, Q9H767	Gene names	ZNF403, LCRG1, LZK1
Domain Architecture	No domain graphic available
Description	Protein ZNF403 (Laryngeal carcinoma-related protein 1).

SYF2_HUMAN
NC score	0.007800 (rank : 47)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	68	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	O95926, Q5TH73	Gene names	SYF2, CBPIN, GCIPIP
Domain Architecture	No domain graphic available
Description	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29).

IPR1_MOUSE
NC score	0.007671 (rank : 48)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	68	Target Neighborhood Hits	65	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BVK9, Q3UCV7, Q80V00	Gene names	Ipr1, Ifi75
Domain Architecture	No domain graphic available
Description	Intracellular pathogen resistance protein 1.

CHIT1_MOUSE
NC score	0.007422 (rank : 49)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	68	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D7Q1, Q6QJD2	Gene names	Chit1
Domain Architecture
Description	Chitotriosidase-1 precursor (EC 3.2.1.14) (Chitinase-1).

HYALP_MOUSE
NC score	0.006917 (rank : 50)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	68	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	P48794, Q7TSD6, Q812F4, Q9DAQ1	Gene names	Spam1, Ph20, Spam
Domain Architecture
Description	Hyaluronidase PH-20 precursor (EC 3.2.1.35) (Hyal-PH20) (Sperm surface protein PH-20) (Sperm adhesion molecule 1).

ADDB_MOUSE
NC score	0.006810 (rank : 51)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	68	Target Neighborhood Hits	574	Shared Neighborhood Hits	6
SwissProt Accessions	Q9QYB8, Q3U0E1, Q80VH9, Q8C1C4, Q9CXE3, Q9JLE5, Q9QYB7	Gene names	Add2
Domain Architecture
Description	Beta-adducin (Erythrocyte adducin subunit beta) (Add97).

PP4R1_HUMAN
NC score	0.006415 (rank : 52)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	68	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TF05, Q99774, Q9UNQ7	Gene names	PPP4R1, MEG1, PP4R1
Domain Architecture
Description	Serine/threonine-protein phosphatase 4 regulatory subunit 1.

ARI4A_HUMAN
NC score	0.006241 (rank : 53)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	68	Target Neighborhood Hits	434	Shared Neighborhood Hits	6
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

GOGA4_HUMAN
NC score	0.006120 (rank : 54)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	68	Target Neighborhood Hits	2034	Shared Neighborhood Hits	15
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

EDG1_MOUSE
NC score	0.005425 (rank : 55)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	68	Target Neighborhood Hits	867	Shared Neighborhood Hits	11
SwissProt Accessions	O08530, Q9R235	Gene names	Edg1, Lpb1
Domain Architecture
Description	Sphingosine 1-phosphate receptor Edg-1 (Sphingosine 1-phosphate receptor 1) (S1P1) (Lysophospholipid receptor B1).

V2R1B_MOUSE
NC score	0.004494 (rank : 56)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	68	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q6TAC4, O70409	Gene names	V2r1b
Domain Architecture	No domain graphic available
Description	Vomeronasal type-2 receptor 1b precursor (Putative pheromone receptor V2R1b).

EYA1_HUMAN
NC score	0.004047 (rank : 57)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	68	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q99502	Gene names	EYA1
Domain Architecture
Description	Eyes absent homolog 1 (EC 3.1.3.48).

LPHN1_HUMAN
NC score	0.003479 (rank : 58)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	68	Target Neighborhood Hits	155	Shared Neighborhood Hits	4
SwissProt Accessions	O94910, Q96IE7, Q9BU07, Q9HAR3	Gene names	LPHN1, KIAA0821, LEC2
Domain Architecture
Description	Latrophilin-1 precursor (Calcium-independent alpha-latrotoxin receptor 1) (Lectomedin-2).

GPR97_MOUSE
NC score	0.003001 (rank : 59)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	68	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R0T6	Gene names	Gpr97
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 97 precursor.

TPM4_MOUSE
NC score	0.002942 (rank : 60)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	68	Target Neighborhood Hits	703	Shared Neighborhood Hits	7
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

TPM4_HUMAN
NC score	0.002454 (rank : 61)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	68	Target Neighborhood Hits	525	Shared Neighborhood Hits	6
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

MYO9B_HUMAN
NC score	0.002242 (rank : 62)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	68	Target Neighborhood Hits	641	Shared Neighborhood Hits	8
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYH10_MOUSE
NC score	0.002027 (rank : 63)	θ value	2.36792 (rank : 34)
Query Neighborhood Hits	68	Target Neighborhood Hits	1612	Shared Neighborhood Hits	11
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.001787 (rank : 64)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	68	Target Neighborhood Hits	1620	Shared Neighborhood Hits	12
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

TRHY_HUMAN
NC score	0.001508 (rank : 65)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	68	Target Neighborhood Hits	1385	Shared Neighborhood Hits	11
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

SPEG_MOUSE
NC score	0.001393 (rank : 66)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	68	Target Neighborhood Hits	1959	Shared Neighborhood Hits	8
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

O1052_MOUSE
NC score	0.000746 (rank : 67)	θ value	1.38821 (rank : 30)
Query Neighborhood Hits	68	Target Neighborhood Hits	684	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VGR8	Gene names	Olfr1052, Mor172-1
Domain Architecture
Description	Olfactory receptor 1052 (Olfactory receptor 172-1).

OR5J2_HUMAN
NC score	-0.000458 (rank : 68)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	68	Target Neighborhood Hits	649	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NH18, Q6IEU5	Gene names	OR5J2
Domain Architecture
Description	Olfactory receptor 5J2 (Olfactory receptor OR11-266).

MASP2_MOUSE
NC score	-0.000761 (rank : 69)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	68	Target Neighborhood Hits	382	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338	Gene names	Masp2
Domain Architecture	No domain graphic available
Description	Mannan-binding lectin serine protease 2 precursor (EC 3.4.21.104) (Mannose-binding protein-associated serine protease 2) (MASP-2) (MBL- associated serine protease 2) [Contains: Mannan-binding lectin serine protease 2 A chain; Mannan-binding lectin serine protease 2 B chain].

SPEG_HUMAN
NC score	-0.001255 (rank : 70)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	68	Target Neighborhood Hits	1762	Shared Neighborhood Hits	9
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

OR5K1_HUMAN
NC score	-0.001403 (rank : 71)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	68	Target Neighborhood Hits	782	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NHB7	Gene names	OR5K1
Domain Architecture
Description	Olfactory receptor 5K1 (HTPCRX10).

EPHA5_MOUSE
NC score	-0.001881 (rank : 72)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	68	Target Neighborhood Hits	950	Shared Neighborhood Hits	6
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA5_HUMAN
NC score	-0.001916 (rank : 73)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	68	Target Neighborhood Hits	1009	Shared Neighborhood Hits	6
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PEG3_MOUSE
NC score	-0.002251 (rank : 74)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	68	Target Neighborhood Hits	1101	Shared Neighborhood Hits	8
SwissProt Accessions	Q3URU2, O54978, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53	Gene names	Peg3, Kiaa0287, Pw1
Domain Architecture	No domain graphic available
Description	Paternally expressed gene 3 protein (ASF-1).