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Network neighborhood for query Sequence : CTR3_HUMAN

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CTR3_HUMAN
SwissProt Accessions	Q8WY07, Q8N185, Q8NCA7, Q96SZ7	Gene names	SLC7A3, ATRC3, CAT3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CTR1_HUMAN
θ value	0 (rank : 1)	NC score	0.990230 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	P30825	Gene names	SLC7A1, ATRC1, REC1L
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor homolog) (ERR) (Ecotropic retrovirus receptor homolog).

CTR3_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WY07, Q8N185, Q8NCA7, Q96SZ7	Gene names	SLC7A3, ATRC3, CAT3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

CTR3_MOUSE
θ value	0 (rank : 3)	NC score	0.995660 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

CTR1_MOUSE
θ value	5.9077e-185 (rank : 4)	NC score	0.989577 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	26
SwissProt Accessions	Q09143, P30824	Gene names	Slc7a1, Atrc1, Rec-1
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor) (ERR) (Ecotropic retrovirus receptor).

CTR2_HUMAN
θ value	9.13544e-178 (rank : 5)	NC score	0.987505 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	38	Shared Neighborhood Hits	28
SwissProt Accessions	P52569	Gene names	SLC7A2, ATRC2
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2).

CTR2_MOUSE
θ value	1.11673e-175 (rank : 6)	NC score	0.986243 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	P18581	Gene names	Slc7a2, Atrc2, Tea
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (TEA protein) (T-cell early activation protein) (20.5).

CTR4_HUMAN
θ value	2.2151e-115 (rank : 7)	NC score	0.977125 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	O43246, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88	Gene names	SLC7A4
Domain Architecture
Description	Cationic amino acid transporter 4 (CAT-4) (CAT4).

LAT1_HUMAN
θ value	2.5182e-18 (rank : 8)	NC score	0.614887 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q01650, Q9UBN8, Q9UP15, Q9UQC0	Gene names	SLC7A5, CD98LC, LAT1, MPE16
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (hLAT1).

BAT1_MOUSE
θ value	3.28887e-18 (rank : 9)	NC score	0.651651 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXA6	Gene names	Slc7a9, Bat1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

LAT1_MOUSE
θ value	1.058e-16 (rank : 10)	NC score	0.613025 (rank : 14)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z127, Q9JMI4	Gene names	Slc7a5, Lat1
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC).

BAT1_HUMAN
θ value	1.80466e-16 (rank : 11)	NC score	0.638775 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	31	Shared Neighborhood Hits	26
SwissProt Accessions	P82251	Gene names	SLC7A9, BAT1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

XCT_HUMAN
θ value	2.35696e-16 (rank : 12)	NC score	0.634260 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPY5	Gene names	SLC7A11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT) (Calcium channel blocker resistance protein CCBR1).

XCT_MOUSE
θ value	2.35696e-16 (rank : 13)	NC score	0.632592 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTR6	Gene names	Slc7a11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT).

AAA1_HUMAN
θ value	9.26847e-13 (rank : 15)	NC score	0.597258 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NS82	Gene names	SLC7A10, ASC1
Domain Architecture
Description	Asc-type amino acid transporter 1 (Asc-1).

YLA1_HUMAN
θ value	2.0648e-12 (rank : 16)	NC score	0.610457 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UM01, O95984, Q9P2V5	Gene names	SLC7A7
Domain Architecture
Description	Y+L amino acid transporter 1 (y(+)L-type amino acid transporter 1) (y+LAT-1) (Y+LAT1) (Monocyte amino acid permease 2) (MOP-2).

LAT2_HUMAN
θ value	1.74796e-11 (rank : 17)	NC score	0.592323 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UHI5, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445	Gene names	SLC7A8, LAT2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2).

LAT2_MOUSE
θ value	2.98157e-11 (rank : 18)	NC score	0.580024 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXW9	Gene names	Slc7a8, Lat2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2).

S12A4_MOUSE
θ value	0.00665767 (rank : 19)	NC score	0.145951 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIS8, O55069, Q9ET57	Gene names	Slc12a4, Kcc1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (mKCC1).

S12A4_HUMAN
θ value	0.0113563 (rank : 20)	NC score	0.148522 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UP95, O60632, O75893, Q13953, Q96LD5	Gene names	SLC12A4, KCC1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1).

S12A7_MOUSE
θ value	0.0113563 (rank : 21)	NC score	0.157260 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVL3	Gene names	Slc12a7, Kcc4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A5_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.144789 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

OPRK_MOUSE
θ value	0.0961366 (rank : 23)	NC score	0.003073 (rank : 39)
Query Neighborhood Hits	35	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P33534	Gene names	Oprk1
Domain Architecture
Description	Kappa-type opioid receptor (KOR-1) (MSL-1).

S12A5_MOUSE
θ value	0.0961366 (rank : 24)	NC score	0.141854 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

S12A6_MOUSE
θ value	0.0961366 (rank : 25)	NC score	0.150988 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	67	Shared Neighborhood Hits	20
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

CLD3_HUMAN
θ value	0.125558 (rank : 26)	NC score	0.027350 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	O15551	Gene names	CLDN3, C7orf1, CPETR2
Domain Architecture
Description	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE- receptor 2) (CPE-R 2) (Ventral prostate.1 protein homolog) (HRVP1).

CLD3_MOUSE
θ value	0.163984 (rank : 27)	NC score	0.024861 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G9, Q91X40	Gene names	Cldn3, Cpetr2
Domain Architecture
Description	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE- receptor 2) (CPE-R 2).

S12A6_HUMAN
θ value	0.163984 (rank : 28)	NC score	0.147021 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A7_HUMAN
θ value	0.163984 (rank : 29)	NC score	0.136341 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y666, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2	Gene names	SLC12A7, KCC4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

CLD1_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.025185 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O95832	Gene names	CLDN1, CLD1, SEMP1
Domain Architecture
Description	Claudin-1 (Senescence-associated epithelial membrane protein).

OR5H2_HUMAN
θ value	0.813845 (rank : 31)	NC score	-0.000473 (rank : 41)
Query Neighborhood Hits	35	Target Neighborhood Hits	642	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGV7	Gene names	OR5H2
Domain Architecture
Description	Olfactory receptor 5H2.

CLD1_MOUSE
θ value	4.03905 (rank : 33)	NC score	0.019898 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	O88551	Gene names	Cldn1
Domain Architecture
Description	Claudin-1.

AQP3_MOUSE
θ value	6.88961 (rank : 34)	NC score	0.005965 (rank : 38)
Query Neighborhood Hits	35	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R2N1, Q9JJN8, Q9WTJ3	Gene names	Aqp3
Domain Architecture
Description	Aquaporin-3 (AQP-3).

ACADV_HUMAN
θ value	8.99809 (rank : 35)	NC score	0.008550 (rank : 37)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P49748, O76056, Q8WUL0	Gene names	ACADVL, VLCAD
Domain Architecture
Description	Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.-) (VLCAD).

S12A1_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.104245 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q13621	Gene names	SLC12A1, NKCC2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter).

S12A1_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.104475 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	P55014, O35938, Q91W55, Q9Z1E0	Gene names	Slc12a1, Nkcc2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (BSC1) (Kidney-specific Na-K-Cl symporter).

S12A2_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.075756 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	P55011, Q8N713, Q8WWH7	Gene names	SLC12A2, NKCC1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A2_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.080280 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A3_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.059734 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P55017	Gene names	SLC12A3, TSC
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A3_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.058577 (rank : 32)
Query Neighborhood Hits	35	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P59158	Gene names	Slc12a3, Tsc
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

Hits sorted by NC score

CTR3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WY07, Q8N185, Q8NCA7, Q96SZ7	Gene names	SLC7A3, ATRC3, CAT3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

CTR3_MOUSE
NC score	0.995660 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	P70423	Gene names	Slc7a3, Atrc3, Cat3
Domain Architecture
Description	Cationic amino acid transporter 3 (CAT-3) (Solute carrier family 7 member 3) (Cationic amino acid transporter y+).

CTR1_HUMAN
NC score	0.990230 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	35	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	P30825	Gene names	SLC7A1, ATRC1, REC1L
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor homolog) (ERR) (Ecotropic retrovirus receptor homolog).

CTR1_MOUSE
NC score	0.989577 (rank : 4)	θ value	5.9077e-185 (rank : 4)
Query Neighborhood Hits	35	Target Neighborhood Hits	36	Shared Neighborhood Hits	26
SwissProt Accessions	Q09143, P30824	Gene names	Slc7a1, Atrc1, Rec-1
Domain Architecture
Description	High-affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (System Y+ basic amino acid transporter) (Ecotropic retroviral leukemia receptor) (ERR) (Ecotropic retrovirus receptor).

CTR2_HUMAN
NC score	0.987505 (rank : 5)	θ value	9.13544e-178 (rank : 5)
Query Neighborhood Hits	35	Target Neighborhood Hits	38	Shared Neighborhood Hits	28
SwissProt Accessions	P52569	Gene names	SLC7A2, ATRC2
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2).

CTR2_MOUSE
NC score	0.986243 (rank : 6)	θ value	1.11673e-175 (rank : 6)
Query Neighborhood Hits	35	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	P18581	Gene names	Slc7a2, Atrc2, Tea
Domain Architecture
Description	Low-affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (TEA protein) (T-cell early activation protein) (20.5).

CTR4_HUMAN
NC score	0.977125 (rank : 7)	θ value	2.2151e-115 (rank : 7)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	22
SwissProt Accessions	O43246, Q3KNQ6, Q4VC45, Q6IBY8, Q96H88	Gene names	SLC7A4
Domain Architecture
Description	Cationic amino acid transporter 4 (CAT-4) (CAT4).

BAT1_MOUSE
NC score	0.651651 (rank : 8)	θ value	3.28887e-18 (rank : 9)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXA6	Gene names	Slc7a9, Bat1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

BAT1_HUMAN
NC score	0.638775 (rank : 9)	θ value	1.80466e-16 (rank : 11)
Query Neighborhood Hits	35	Target Neighborhood Hits	31	Shared Neighborhood Hits	26
SwissProt Accessions	P82251	Gene names	SLC7A9, BAT1
Domain Architecture
Description	B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein- associated amino acid transporter b0,+AT1).

XCT_HUMAN
NC score	0.634260 (rank : 10)	θ value	2.35696e-16 (rank : 12)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UPY5	Gene names	SLC7A11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT) (Calcium channel blocker resistance protein CCBR1).

XCT_MOUSE
NC score	0.632592 (rank : 11)	θ value	2.35696e-16 (rank : 13)
Query Neighborhood Hits	35	Target Neighborhood Hits	23	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTR6	Gene names	Slc7a11
Domain Architecture
Description	Cystine/glutamate transporter (Amino acid transport system xc-) (xCT).

LAT1_HUMAN
NC score	0.614887 (rank : 13)	θ value	2.5182e-18 (rank : 8)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q01650, Q9UBN8, Q9UP15, Q9UQC0	Gene names	SLC7A5, CD98LC, LAT1, MPE16
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (hLAT1).

LAT1_MOUSE
NC score	0.613025 (rank : 14)	θ value	1.058e-16 (rank : 10)
Query Neighborhood Hits	35	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z127, Q9JMI4	Gene names	Slc7a5, Lat1
Domain Architecture
Description	Large neutral amino acids transporter small subunit 1 (L-type amino acid transporter 1) (4F2 light chain) (4F2 LC) (4F2LC).

YLA1_HUMAN
NC score	0.610457 (rank : 15)	θ value	2.0648e-12 (rank : 16)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UM01, O95984, Q9P2V5	Gene names	SLC7A7
Domain Architecture
Description	Y+L amino acid transporter 1 (y(+)L-type amino acid transporter 1) (y+LAT-1) (Y+LAT1) (Monocyte amino acid permease 2) (MOP-2).

AAA1_HUMAN
NC score	0.597258 (rank : 16)	θ value	9.26847e-13 (rank : 15)
Query Neighborhood Hits	35	Target Neighborhood Hits	25	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NS82	Gene names	SLC7A10, ASC1
Domain Architecture
Description	Asc-type amino acid transporter 1 (Asc-1).

LAT2_HUMAN
NC score	0.592323 (rank : 17)	θ value	1.74796e-11 (rank : 17)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UHI5, Q9UKQ6, Q9UKQ7, Q9UKQ8, Q9Y445	Gene names	SLC7A8, LAT2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2).

LAT2_MOUSE
NC score	0.580024 (rank : 18)	θ value	2.98157e-11 (rank : 18)
Query Neighborhood Hits	35	Target Neighborhood Hits	30	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QXW9	Gene names	Slc7a8, Lat2
Domain Architecture
Description	Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2).

S12A7_MOUSE
NC score	0.157260 (rank : 19)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	35	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WVL3	Gene names	Slc12a7, Kcc4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A6_MOUSE
NC score	0.150988 (rank : 20)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	35	Target Neighborhood Hits	67	Shared Neighborhood Hits	20
SwissProt Accessions	Q924N4, Q924N3	Gene names	Slc12a6, Kcc3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A4_HUMAN
NC score	0.148522 (rank : 21)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UP95, O60632, O75893, Q13953, Q96LD5	Gene names	SLC12A4, KCC1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1).

S12A6_HUMAN
NC score	0.147021 (rank : 22)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	35	Target Neighborhood Hits	58	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

S12A4_MOUSE
NC score	0.145951 (rank : 23)	θ value	0.00665767 (rank : 19)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JIS8, O55069, Q9ET57	Gene names	Slc12a4, Kcc1
Domain Architecture
Description	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (mKCC1).

S12A5_HUMAN
NC score	0.144789 (rank : 24)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	35	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H2X9, Q5VZ41, Q9H4Z0, Q9ULP4	Gene names	SLC12A5, KCC2, KIAA1176
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Erythroid K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (hKCC2).

S12A5_MOUSE
NC score	0.141854 (rank : 25)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	35	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q91V14, Q9Z0M7	Gene names	Slc12a5, Kcc2
Domain Architecture
Description	Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (Neuronal K-Cl cotransporter) (mKCC2).

S12A7_HUMAN
NC score	0.136341 (rank : 26)	θ value	0.163984 (rank : 29)
Query Neighborhood Hits	35	Target Neighborhood Hits	46	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y666, Q96I81, Q9H7I3, Q9H7I7, Q9UFW2	Gene names	SLC12A7, KCC4
Domain Architecture
Description	Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4).

S12A1_MOUSE
NC score	0.104475 (rank : 27)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	35	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	P55014, O35938, Q91W55, Q9Z1E0	Gene names	Slc12a1, Nkcc2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (BSC1) (Kidney-specific Na-K-Cl symporter).

S12A1_HUMAN
NC score	0.104245 (rank : 28)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	35	Target Neighborhood Hits	28	Shared Neighborhood Hits	16
SwissProt Accessions	Q13621	Gene names	SLC12A1, NKCC2
Domain Architecture
Description	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter).

S12A2_MOUSE
NC score	0.080280 (rank : 29)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	35	Target Neighborhood Hits	55	Shared Neighborhood Hits	15
SwissProt Accessions	P55012	Gene names	Slc12a2, Nkcc1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A2_HUMAN
NC score	0.075756 (rank : 30)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	35	Target Neighborhood Hits	56	Shared Neighborhood Hits	16
SwissProt Accessions	P55011, Q8N713, Q8WWH7	Gene names	SLC12A2, NKCC1
Domain Architecture
Description	Solute carrier family 12 member 2 (Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 1) (Basolateral Na-K-Cl symporter).

S12A3_HUMAN
NC score	0.059734 (rank : 31)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	35	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	P55017	Gene names	SLC12A3, TSC
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

S12A3_MOUSE
NC score	0.058577 (rank : 32)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	35	Target Neighborhood Hits	23	Shared Neighborhood Hits	12
SwissProt Accessions	P59158	Gene names	Slc12a3, Tsc
Domain Architecture
Description	Solute carrier family 12 member 3 (Thiazide-sensitive sodium-chloride cotransporter) (Na-Cl symporter).

CLD3_HUMAN
NC score	0.027350 (rank : 33)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	35	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	O15551	Gene names	CLDN3, C7orf1, CPETR2
Domain Architecture
Description	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE- receptor 2) (CPE-R 2) (Ventral prostate.1 protein homolog) (HRVP1).

CLD1_HUMAN
NC score	0.025185 (rank : 34)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	35	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O95832	Gene names	CLDN1, CLD1, SEMP1
Domain Architecture
Description	Claudin-1 (Senescence-associated epithelial membrane protein).

CLD3_MOUSE
NC score	0.024861 (rank : 35)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	35	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G9, Q91X40	Gene names	Cldn3, Cpetr2
Domain Architecture
Description	Claudin-3 (Clostridium perfringens enterotoxin receptor 2) (CPE- receptor 2) (CPE-R 2).

CLD1_MOUSE
NC score	0.019898 (rank : 36)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	35	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	O88551	Gene names	Cldn1
Domain Architecture
Description	Claudin-1.

ACADV_HUMAN
NC score	0.008550 (rank : 37)	θ value	8.99809 (rank : 35)
Query Neighborhood Hits	35	Target Neighborhood Hits	35	Shared Neighborhood Hits	3
SwissProt Accessions	P49748, O76056, Q8WUL0	Gene names	ACADVL, VLCAD
Domain Architecture
Description	Very-long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor (EC 1.3.99.-) (VLCAD).

AQP3_MOUSE
NC score	0.005965 (rank : 38)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	35	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R2N1, Q9JJN8, Q9WTJ3	Gene names	Aqp3
Domain Architecture
Description	Aquaporin-3 (AQP-3).

OPRK_MOUSE
NC score	0.003073 (rank : 39)	θ value	0.0961366 (rank : 23)
Query Neighborhood Hits	35	Target Neighborhood Hits	906	Shared Neighborhood Hits	3
SwissProt Accessions	P33534	Gene names	Oprk1
Domain Architecture
Description	Kappa-type opioid receptor (KOR-1) (MSL-1).

OR5H2_HUMAN
NC score	-0.000473 (rank : 41)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	35	Target Neighborhood Hits	642	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NGV7	Gene names	OR5H2
Domain Architecture
Description	Olfactory receptor 5H2.