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Network neighborhood for query Sequence : SYV_HUMAN

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SYV_HUMAN
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SYV_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYV_MOUSE
θ value	0 (rank : 2)	NC score	0.994258 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1Q9, Q9QUN2	Gene names	Vars, Bat6, G7a, Vars2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYIM_MOUSE
θ value	8.57503e-51 (rank : 3)	NC score	0.760131 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYIM_HUMAN
θ value	4.70527e-49 (rank : 4)	NC score	0.753741 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NSE4, Q6PI85, Q7L439, Q86WU9, Q96D91	Gene names	IARS2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYIC_HUMAN
θ value	1.01765e-35 (rank : 5)	NC score	0.689573 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

SYIC_MOUSE
θ value	3.61944e-33 (rank : 6)	NC score	0.688242 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BU30	Gene names	Iars
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

EF1G_HUMAN
θ value	7.80994e-28 (rank : 7)	NC score	0.560372 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196	Gene names	EEF1G, EF1G
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

EF1G_MOUSE
θ value	2.27234e-27 (rank : 8)	NC score	0.559387 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D8N0, Q920C5, Q9CRT5, Q9CSU3, Q9D004	Gene names	Eef1g
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

SYLM_HUMAN
θ value	4.91457e-14 (rank : 9)	NC score	0.489554 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q15031	Gene names	LARS2, KIAA0028
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLM_MOUSE
θ value	7.09661e-13 (rank : 10)	NC score	0.484694 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VDC0	Gene names	Lars2
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYMM_MOUSE
θ value	1.43324e-05 (rank : 11)	NC score	0.249409 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	13
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYMM_HUMAN
θ value	0.00020696 (rank : 12)	NC score	0.227947 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYLC_HUMAN
θ value	0.00102713 (rank : 13)	NC score	0.248837 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2J5, Q9NSE1	Gene names	LARS, KIAA1352
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLC_MOUSE
θ value	0.00134147 (rank : 14)	NC score	0.242537 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMJ2, Q8BKW9	Gene names	Lars
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

MCA3_MOUSE
θ value	0.0330416 (rank : 15)	NC score	0.166785 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D1M4	Gene names	Eef1e1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

RBP1_HUMAN
θ value	0.0330416 (rank : 16)	NC score	0.039601 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	521	Shared Neighborhood Hits	6
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SYM_HUMAN
θ value	0.0431538 (rank : 17)	NC score	0.146858 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	16
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

RBP1_MOUSE
θ value	0.0736092 (rank : 18)	NC score	0.038352 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	493	Shared Neighborhood Hits	6
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

MAST4_HUMAN
θ value	0.279714 (rank : 19)	NC score	0.006401 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	1804	Shared Neighborhood Hits	9
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MCA3_HUMAN
θ value	0.47712 (rank : 20)	NC score	0.115207 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	O43324, Q5THS2	Gene names	EEF1E1
Domain Architecture
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYEP_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.060946 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	123	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

CP135_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.006687 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	1278	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

ITSN1_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.004123 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	1669	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

KCNH1_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.019009 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH1_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.019016 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

RAD50_MOUSE
θ value	3.0926 (rank : 26)	NC score	0.005665 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	1366	Shared Neighborhood Hits	8
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

GSTT2_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.062728 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P30712, O60665, Q9HD76	Gene names	GSTT2
Domain Architecture
Description	Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2).

KS6B1_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.005055 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.005049 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	849	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

CAH13_HUMAN
θ value	5.27518 (rank : 30)	NC score	0.005967 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N1Q1	Gene names	CA13
Domain Architecture
Description	Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonic anhydrase XIII) (Carbonate dehydratase XIII) (CA-XIII).

KS6B2_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.004559 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

DESP_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.007580 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	1470	Shared Neighborhood Hits	10
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

MICA1_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.006683 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

PMYT1_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.003209 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	814	Shared Neighborhood Hits	7
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

ZO2_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.006394 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	289	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CELR1_HUMAN
θ value	8.99809 (rank : 36)	NC score	-0.000058 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	613	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).

K0226_MOUSE
θ value	8.99809 (rank : 37)	NC score	0.010107 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

KCNH5_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.012131 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

KS6B2_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.003142 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	871	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PCLO_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.002919 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	2275	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRGC2_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.009191 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	272	Shared Neighborhood Hits	4
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

SYM_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.100086 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

Hits sorted by NC score

SYV_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	41
SwissProt Accessions	P26640, Q5JQ90, Q96E77, Q9UQM2	Gene names	VARS, G7A, VARS2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYV_MOUSE
NC score	0.994258 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	41	Target Neighborhood Hits	47	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Z1Q9, Q9QUN2	Gene names	Vars, Bat6, G7a, Vars2
Domain Architecture
Description	Valyl-tRNA synthetase (EC 6.1.1.9) (Valine--tRNA ligase) (ValRS) (Protein G7a).

SYIM_MOUSE
NC score	0.760131 (rank : 3)	θ value	8.57503e-51 (rank : 3)
Query Neighborhood Hits	41	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYIM_HUMAN
NC score	0.753741 (rank : 4)	θ value	4.70527e-49 (rank : 4)
Query Neighborhood Hits	41	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NSE4, Q6PI85, Q7L439, Q86WU9, Q96D91	Gene names	IARS2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYIC_HUMAN
NC score	0.689573 (rank : 5)	θ value	1.01765e-35 (rank : 5)
Query Neighborhood Hits	41	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	P41252, Q5TCD0, Q9H588	Gene names	IARS
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

SYIC_MOUSE
NC score	0.688242 (rank : 6)	θ value	3.61944e-33 (rank : 6)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BU30	Gene names	Iars
Domain Architecture
Description	Isoleucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS) (IRS).

EF1G_HUMAN
NC score	0.560372 (rank : 7)	θ value	7.80994e-28 (rank : 7)
Query Neighborhood Hits	41	Target Neighborhood Hits	30	Shared Neighborhood Hits	9
SwissProt Accessions	P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196	Gene names	EEF1G, EF1G
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

EF1G_MOUSE
NC score	0.559387 (rank : 8)	θ value	2.27234e-27 (rank : 8)
Query Neighborhood Hits	41	Target Neighborhood Hits	31	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D8N0, Q920C5, Q9CRT5, Q9CSU3, Q9D004	Gene names	Eef1g
Domain Architecture
Description	Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma).

SYLM_HUMAN
NC score	0.489554 (rank : 9)	θ value	4.91457e-14 (rank : 9)
Query Neighborhood Hits	41	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q15031	Gene names	LARS2, KIAA0028
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLM_MOUSE
NC score	0.484694 (rank : 10)	θ value	7.09661e-13 (rank : 10)
Query Neighborhood Hits	41	Target Neighborhood Hits	21	Shared Neighborhood Hits	13
SwissProt Accessions	Q8VDC0	Gene names	Lars2
Domain Architecture
Description	Probable leucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYMM_MOUSE
NC score	0.249409 (rank : 11)	θ value	1.43324e-05 (rank : 11)
Query Neighborhood Hits	41	Target Neighborhood Hits	28	Shared Neighborhood Hits	13
SwissProt Accessions	Q499X9, Q3T9W7, Q8BWR9, Q8BXY1	Gene names	Mars2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

SYLC_HUMAN
NC score	0.248837 (rank : 12)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	41	Target Neighborhood Hits	26	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2J5, Q9NSE1	Gene names	LARS, KIAA1352
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYLC_MOUSE
NC score	0.242537 (rank : 13)	θ value	0.00134147 (rank : 14)
Query Neighborhood Hits	41	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BMJ2, Q8BKW9	Gene names	Lars
Domain Architecture
Description	Leucyl-tRNA synthetase, cytoplasmic (EC 6.1.1.4) (Leucine--tRNA ligase) (LeuRS).

SYMM_HUMAN
NC score	0.227947 (rank : 14)	θ value	0.00020696 (rank : 12)
Query Neighborhood Hits	41	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q96GW9, Q76E79, Q8IW62, Q8N7N4	Gene names	MARS2
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.10) (Methionine--tRNA ligase 2) (Mitochondrial methionine--tRNA ligase) (MtMetRS).

MCA3_MOUSE
NC score	0.166785 (rank : 15)	θ value	0.0330416 (rank : 15)
Query Neighborhood Hits	41	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D1M4	Gene names	Eef1e1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYM_HUMAN
NC score	0.146858 (rank : 16)	θ value	0.0431538 (rank : 17)
Query Neighborhood Hits	41	Target Neighborhood Hits	43	Shared Neighborhood Hits	16
SwissProt Accessions	P56192, Q14895, Q53H14, Q96A15, Q96BZ0, Q9NSE0	Gene names	MARS
Domain Architecture
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

MCA3_HUMAN
NC score	0.115207 (rank : 17)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	41	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	O43324, Q5THS2	Gene names	EEF1E1
Domain Architecture
Description	Eukaryotic translation elongation factor 1 epsilon-1 (Multisynthetase complex auxiliary component p18) (Elongation factor p18).

SYM_MOUSE
NC score	0.100086 (rank : 18)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	41	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q68FL6	Gene names	Mars
Domain Architecture	No domain graphic available
Description	Methionyl-tRNA synthetase (EC 6.1.1.10) (Methionine--tRNA ligase) (MetRS).

GSTT2_HUMAN
NC score	0.062728 (rank : 19)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	41	Target Neighborhood Hits	19	Shared Neighborhood Hits	5
SwissProt Accessions	P30712, O60665, Q9HD76	Gene names	GSTT2
Domain Architecture
Description	Glutathione S-transferase theta-2 (EC 2.5.1.18) (GST class-theta-2).

SYEP_MOUSE
NC score	0.060946 (rank : 20)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	41	Target Neighborhood Hits	123	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CGC7	Gene names	Eprs, Qprs
Domain Architecture	No domain graphic available
Description	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase (EC 6.1.1.17) (Glutamate--tRNA ligase); Prolyl-tRNA synthetase (EC 6.1.1.15) (Proline--tRNA ligase)].

RBP1_HUMAN
NC score	0.039601 (rank : 21)	θ value	0.0330416 (rank : 16)
Query Neighborhood Hits	41	Target Neighborhood Hits	521	Shared Neighborhood Hits	6
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
NC score	0.038352 (rank : 22)	θ value	0.0736092 (rank : 18)
Query Neighborhood Hits	41	Target Neighborhood Hits	493	Shared Neighborhood Hits	6
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

KCNH1_MOUSE
NC score	0.019016 (rank : 23)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	41	Target Neighborhood Hits	94	Shared Neighborhood Hits	5
SwissProt Accessions	Q60603	Gene names	Kcnh1, Eag
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (EAG1) (m-eag).

KCNH1_HUMAN
NC score	0.019009 (rank : 24)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	41	Target Neighborhood Hits	98	Shared Neighborhood Hits	5
SwissProt Accessions	O95259, O76035	Gene names	KCNH1, EAG, EAG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag).

KCNH5_MOUSE
NC score	0.012131 (rank : 25)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	41	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q920E3, Q8C035	Gene names	Kcnh5, Eag2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily H member 5 (Voltage-gated potassium channel subunit Kv10.2) (Ether-a-go-go potassium channel 2) (Eag2).

K0226_MOUSE
NC score	0.010107 (rank : 26)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	41	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

PRGC2_HUMAN
NC score	0.009191 (rank : 27)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	41	Target Neighborhood Hits	272	Shared Neighborhood Hits	4
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

DESP_HUMAN
NC score	0.007580 (rank : 28)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	41	Target Neighborhood Hits	1470	Shared Neighborhood Hits	10
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

CP135_MOUSE
NC score	0.006687 (rank : 29)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	41	Target Neighborhood Hits	1278	Shared Neighborhood Hits	7
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

MICA1_HUMAN
NC score	0.006683 (rank : 30)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	41	Target Neighborhood Hits	279	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MAST4_HUMAN
NC score	0.006401 (rank : 31)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	41	Target Neighborhood Hits	1804	Shared Neighborhood Hits	9
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ZO2_HUMAN
NC score	0.006394 (rank : 32)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	41	Target Neighborhood Hits	289	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UDY2, Q15883, Q8N756, Q8NI14, Q99839, Q9UDY0, Q9UDY1	Gene names	TJP2, X104, ZO2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

CAH13_HUMAN
NC score	0.005967 (rank : 33)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	41	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N1Q1	Gene names	CA13
Domain Architecture
Description	Carbonic anhydrase 13 (EC 4.2.1.1) (Carbonic anhydrase XIII) (Carbonate dehydratase XIII) (CA-XIII).

RAD50_MOUSE
NC score	0.005665 (rank : 34)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	41	Target Neighborhood Hits	1366	Shared Neighborhood Hits	8
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

KS6B1_HUMAN
NC score	0.005055 (rank : 35)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	41	Target Neighborhood Hits	850	Shared Neighborhood Hits	8
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
NC score	0.005049 (rank : 36)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	41	Target Neighborhood Hits	849	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
NC score	0.004559 (rank : 37)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	41	Target Neighborhood Hits	858	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

ITSN1_MOUSE
NC score	0.004123 (rank : 38)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	41	Target Neighborhood Hits	1669	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PMYT1_HUMAN
NC score	0.003209 (rank : 39)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	41	Target Neighborhood Hits	814	Shared Neighborhood Hits	7
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KS6B2_MOUSE
NC score	0.003142 (rank : 40)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	41	Target Neighborhood Hits	871	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PCLO_MOUSE
NC score	0.002919 (rank : 41)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	41	Target Neighborhood Hits	2275	Shared Neighborhood Hits	10
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CELR1_HUMAN
NC score	-0.000058 (rank : 42)	θ value	8.99809 (rank : 36)
Query Neighborhood Hits	41	Target Neighborhood Hits	613	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NYQ6, O95722, Q5TH47, Q9BWQ5, Q9Y506, Q9Y526	Gene names	CELSR1, CDHF9, FMI2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 1 precursor (Flamingo homolog 2) (hFmi2).