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Network neighborhood for query Sequence : MYOD1_HUMAN

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MYOD1_HUMAN
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MYOD1_HUMAN
θ value	7.02726e-162 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	6.62324e-136 (rank : 2)	NC score	0.990038 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	72
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYF5_HUMAN
θ value	2.75849e-49 (rank : 3)	NC score	0.929813 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
θ value	1.28137e-46 (rank : 4)	NC score	0.928236 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYOG_HUMAN
θ value	2.87452e-22 (rank : 5)	NC score	0.830539 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYF6_HUMAN
θ value	5.42112e-21 (rank : 6)	NC score	0.841764 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
θ value	5.42112e-21 (rank : 7)	NC score	0.839812 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

MYOG_MOUSE
θ value	2.69047e-20 (rank : 8)	NC score	0.817634 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

LYL1_MOUSE
θ value	7.1131e-05 (rank : 9)	NC score	0.428755 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

PTF1A_HUMAN
θ value	0.000121331 (rank : 10)	NC score	0.475751 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
θ value	0.000121331 (rank : 11)	NC score	0.469964 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

TWST1_HUMAN
θ value	0.000121331 (rank : 12)	NC score	0.483314 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	93	Shared Neighborhood Hits	63
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	0.000121331 (rank : 13)	NC score	0.483021 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	63
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TWST2_HUMAN
θ value	0.000270298 (rank : 14)	NC score	0.461231 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	0.000270298 (rank : 15)	NC score	0.461921 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TAL1_MOUSE
θ value	0.00035302 (rank : 16)	NC score	0.442877 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	110	Shared Neighborhood Hits	59
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TAL1_HUMAN
θ value	0.000602161 (rank : 17)	NC score	0.436519 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

ASCL1_MOUSE
θ value	0.00102713 (rank : 18)	NC score	0.440392 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

LYL1_HUMAN
θ value	0.00102713 (rank : 19)	NC score	0.426637 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

NGN1_MOUSE
θ value	0.00102713 (rank : 20)	NC score	0.395509 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	51
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

ASCL1_HUMAN
θ value	0.00134147 (rank : 21)	NC score	0.435626 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

NGN1_HUMAN
θ value	0.00134147 (rank : 22)	NC score	0.391611 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	51
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

FIGLA_HUMAN
θ value	0.00175202 (rank : 23)	NC score	0.478991 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

NGN3_MOUSE
θ value	0.00175202 (rank : 24)	NC score	0.394350 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	90	Shared Neighborhood Hits	53
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

TCF15_MOUSE
θ value	0.00175202 (rank : 25)	NC score	0.369950 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	51
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

GNAS1_MOUSE
θ value	0.00228821 (rank : 26)	NC score	0.032769 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	651	Shared Neighborhood Hits	15
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

FIGLA_MOUSE
θ value	0.00298849 (rank : 27)	NC score	0.472246 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

ASCL3_MOUSE
θ value	0.00665767 (rank : 28)	NC score	0.446245 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

SCX_MOUSE
θ value	0.00869519 (rank : 29)	NC score	0.401567 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

TFE2_HUMAN
θ value	0.00869519 (rank : 30)	NC score	0.227385 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

HAND1_MOUSE
θ value	0.0113563 (rank : 31)	NC score	0.373566 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	53
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

HAND2_HUMAN
θ value	0.0148317 (rank : 32)	NC score	0.397732 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	0.0148317 (rank : 33)	NC score	0.397732 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

NDF2_HUMAN
θ value	0.0148317 (rank : 34)	NC score	0.340235 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
θ value	0.0148317 (rank : 35)	NC score	0.340213 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

ASCL3_HUMAN
θ value	0.0252991 (rank : 36)	NC score	0.428639 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

NGN3_HUMAN
θ value	0.0252991 (rank : 37)	NC score	0.377704 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

ASCL2_MOUSE
θ value	0.0330416 (rank : 38)	NC score	0.442649 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	55
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

MNT_HUMAN
θ value	0.0330416 (rank : 39)	NC score	0.195534 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	496	Shared Neighborhood Hits	40
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	0.0330416 (rank : 40)	NC score	0.202725 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	432	Shared Neighborhood Hits	40
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NDF1_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.323415 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	186	Shared Neighborhood Hits	55
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

NDF1_MOUSE
θ value	0.0330416 (rank : 42)	NC score	0.321584 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	209	Shared Neighborhood Hits	57
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

ASCL2_HUMAN
θ value	0.0431538 (rank : 43)	NC score	0.432382 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	54
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

BHLH8_HUMAN
θ value	0.0431538 (rank : 44)	NC score	0.396835 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	66
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

HTF4_HUMAN
θ value	0.0736092 (rank : 45)	NC score	0.204368 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

HTF4_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.211937 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	153	Shared Neighborhood Hits	38
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

NDF4_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.323349 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	91	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

NDF4_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.324082 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

TFE2_MOUSE
θ value	0.0736092 (rank : 49)	NC score	0.211630 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

BHLH8_MOUSE
θ value	0.0961366 (rank : 50)	NC score	0.391885 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

ITF2_HUMAN
θ value	0.0961366 (rank : 51)	NC score	0.205454 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	36
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	0.0961366 (rank : 52)	NC score	0.205233 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

HAND1_HUMAN
θ value	0.125558 (rank : 53)	NC score	0.356914 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	53
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

ID1_HUMAN
θ value	0.125558 (rank : 54)	NC score	0.203476 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	63	Shared Neighborhood Hits	40
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

NGN2_HUMAN
θ value	0.125558 (rank : 55)	NC score	0.348117 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	92	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN2_MOUSE
θ value	0.125558 (rank : 56)	NC score	0.347666 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

OGFR_HUMAN
θ value	0.163984 (rank : 57)	NC score	0.030874 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

BAT3_MOUSE
θ value	0.21417 (rank : 58)	NC score	0.041186 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	518	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

HES1_HUMAN
θ value	0.21417 (rank : 59)	NC score	0.114636 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.114725 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	14
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MYC_MOUSE
θ value	0.279714 (rank : 61)	NC score	0.170834 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TFAP4_HUMAN
θ value	0.279714 (rank : 62)	NC score	0.306159 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	289	Shared Neighborhood Hits	50
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

ATF6B_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.036683 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

MAGC1_HUMAN
θ value	0.365318 (rank : 64)	NC score	0.021234 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	431	Shared Neighborhood Hits	7
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

MARCS_MOUSE
θ value	0.813845 (rank : 65)	NC score	0.036249 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

MYOM1_MOUSE
θ value	0.813845 (rank : 66)	NC score	0.014318 (rank : 118)
Query Neighborhood Hits	100	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

TARA_MOUSE
θ value	0.813845 (rank : 67)	NC score	0.018622 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	1133	Shared Neighborhood Hits	18
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TTLL5_HUMAN
θ value	0.813845 (rank : 68)	NC score	0.027034 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

HES6_HUMAN
θ value	1.38821 (rank : 69)	NC score	0.074972 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

SHAN1_HUMAN
θ value	1.81305 (rank : 70)	NC score	0.008676 (rank : 122)
Query Neighborhood Hits	100	Target Neighborhood Hits	1041	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

HES6_MOUSE
θ value	2.36792 (rank : 71)	NC score	0.068316 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

PRRT3_HUMAN
θ value	2.36792 (rank : 72)	NC score	0.026699 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

TF3C2_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.033308 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

CCNK_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.021275 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	12
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

FOG1_MOUSE
θ value	3.0926 (rank : 75)	NC score	0.002754 (rank : 129)
Query Neighborhood Hits	100	Target Neighborhood Hits	1237	Shared Neighborhood Hits	15
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HES2_MOUSE
θ value	3.0926 (rank : 76)	NC score	0.069858 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

MYC_HUMAN
θ value	3.0926 (rank : 77)	NC score	0.133339 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

NOLC1_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.015567 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	452	Shared Neighborhood Hits	7
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

R4RL2_MOUSE
θ value	4.03905 (rank : 79)	NC score	0.004546 (rank : 126)
Query Neighborhood Hits	100	Target Neighborhood Hits	279	Shared Neighborhood Hits	3
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

RFX1_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.012821 (rank : 119)
Query Neighborhood Hits	100	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

RUSC1_HUMAN
θ value	4.03905 (rank : 81)	NC score	0.014747 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	226	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

TCF15_HUMAN
θ value	4.03905 (rank : 82)	NC score	0.315400 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

TF3C2_MOUSE
θ value	4.03905 (rank : 83)	NC score	0.031008 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	165	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

HES4_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.081039 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

ID4_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.162540 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.158112 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

PRP2_MOUSE
θ value	5.27518 (rank : 87)	NC score	0.018807 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

PTN23_MOUSE
θ value	5.27518 (rank : 88)	NC score	0.008747 (rank : 121)
Query Neighborhood Hits	100	Target Neighborhood Hits	726	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

ARHG2_HUMAN
θ value	6.88961 (rank : 89)	NC score	0.006872 (rank : 124)
Query Neighborhood Hits	100	Target Neighborhood Hits	142	Shared Neighborhood Hits	2
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CI005_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.019141 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H330, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6	Gene names	C9orf5
Domain Architecture	No domain graphic available
Description	Protein C9orf5 (Protein CG-2).

MAX_HUMAN
θ value	6.88961 (rank : 91)	NC score	0.102553 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	6.88961 (rank : 92)	NC score	0.109453 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	139	Shared Neighborhood Hits	28
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

PDC6I_MOUSE
θ value	6.88961 (rank : 93)	NC score	0.016845 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	275	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

SOS1_MOUSE
θ value	6.88961 (rank : 94)	NC score	0.008260 (rank : 123)
Query Neighborhood Hits	100	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TSP1_MOUSE
θ value	6.88961 (rank : 95)	NC score	0.003832 (rank : 127)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	3
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

EVL_HUMAN
θ value	8.99809 (rank : 96)	NC score	0.009215 (rank : 120)
Query Neighborhood Hits	100	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

NRG2_HUMAN
θ value	8.99809 (rank : 97)	NC score	0.004561 (rank : 125)
Query Neighborhood Hits	100	Target Neighborhood Hits	419	Shared Neighborhood Hits	3
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

R4RL2_HUMAN
θ value	8.99809 (rank : 98)	NC score	0.003407 (rank : 128)
Query Neighborhood Hits	100	Target Neighborhood Hits	273	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

TTLL5_MOUSE
θ value	8.99809 (rank : 99)	NC score	0.029773 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

WNK2_HUMAN
θ value	8.99809 (rank : 100)	NC score	-0.000772 (rank : 130)
Query Neighborhood Hits	100	Target Neighborhood Hits	1407	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ATOH1_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.251765 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	53
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

ATOH1_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.258348 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	55
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

BHLH4_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.190497 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

BHLH4_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.184740 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

HEN1_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.298030 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	51
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.295472 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	51
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.285973 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.284861 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

ID1_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.140133 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID2_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.090633 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

ID2_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.084435 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

MUSC_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.240016 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

MUSC_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.244122 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

MYCL1_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.059932 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.054799 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	29
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCN_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.076824 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.076754 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCS_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.077644 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

NDF6_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.237306 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	91	Shared Neighborhood Hits	50
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
θ value	θ > 10 (rank : 120)	NC score	0.236262 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	50
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

OLIG1_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.171656 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

OLIG1_MOUSE
θ value	θ > 10 (rank : 122)	NC score	0.168106 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

OLIG2_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.169667 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

OLIG2_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.168999 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	74	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG3_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.160734 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	37
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

OLIG3_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.162395 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

TAL2_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.325025 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

TAL2_MOUSE
θ value	θ > 10 (rank : 128)	NC score	0.324150 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

TCF21_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.235285 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

TCF21_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.234046 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

Hits sorted by NC score

MYOD1_HUMAN
NC score	0.999962 (rank : 1)	θ value	7.02726e-162 (rank : 1)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	100
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
NC score	0.990038 (rank : 2)	θ value	6.62324e-136 (rank : 2)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	72
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYF5_HUMAN
NC score	0.929813 (rank : 3)	θ value	2.75849e-49 (rank : 3)
Query Neighborhood Hits	100	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
NC score	0.928236 (rank : 4)	θ value	1.28137e-46 (rank : 4)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	62
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF6_HUMAN
NC score	0.841764 (rank : 5)	θ value	5.42112e-21 (rank : 6)
Query Neighborhood Hits	100	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
NC score	0.839812 (rank : 6)	θ value	5.42112e-21 (rank : 7)
Query Neighborhood Hits	100	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

MYOG_HUMAN
NC score	0.830539 (rank : 7)	θ value	2.87452e-22 (rank : 5)
Query Neighborhood Hits	100	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
NC score	0.817634 (rank : 8)	θ value	2.69047e-20 (rank : 8)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	58
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

TWST1_HUMAN
NC score	0.483314 (rank : 9)	θ value	0.000121331 (rank : 12)
Query Neighborhood Hits	100	Target Neighborhood Hits	93	Shared Neighborhood Hits	63
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
NC score	0.483021 (rank : 10)	θ value	0.000121331 (rank : 13)
Query Neighborhood Hits	100	Target Neighborhood Hits	101	Shared Neighborhood Hits	63
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

FIGLA_HUMAN
NC score	0.478991 (rank : 11)	θ value	0.00175202 (rank : 23)
Query Neighborhood Hits	100	Target Neighborhood Hits	108	Shared Neighborhood Hits	61
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

PTF1A_HUMAN
NC score	0.475751 (rank : 12)	θ value	0.000121331 (rank : 10)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

FIGLA_MOUSE
NC score	0.472246 (rank : 13)	θ value	0.00298849 (rank : 27)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

PTF1A_MOUSE
NC score	0.469964 (rank : 14)	θ value	0.000121331 (rank : 11)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

TWST2_MOUSE
NC score	0.461921 (rank : 15)	θ value	0.000270298 (rank : 15)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.461231 (rank : 16)	θ value	0.000270298 (rank : 14)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

ASCL3_MOUSE
NC score	0.446245 (rank : 17)	θ value	0.00665767 (rank : 28)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

TAL1_MOUSE
NC score	0.442877 (rank : 18)	θ value	0.00035302 (rank : 16)
Query Neighborhood Hits	100	Target Neighborhood Hits	110	Shared Neighborhood Hits	59
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

ASCL2_MOUSE
NC score	0.442649 (rank : 19)	θ value	0.0330416 (rank : 38)
Query Neighborhood Hits	100	Target Neighborhood Hits	98	Shared Neighborhood Hits	55
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

ASCL1_MOUSE
NC score	0.440392 (rank : 20)	θ value	0.00102713 (rank : 18)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	56
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

TAL1_HUMAN
NC score	0.436519 (rank : 21)	θ value	0.000602161 (rank : 17)
Query Neighborhood Hits	100	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

ASCL1_HUMAN
NC score	0.435626 (rank : 22)	θ value	0.00134147 (rank : 21)
Query Neighborhood Hits	100	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ASCL2_HUMAN
NC score	0.432382 (rank : 23)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	54
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

LYL1_MOUSE
NC score	0.428755 (rank : 24)	θ value	7.1131e-05 (rank : 9)
Query Neighborhood Hits	100	Target Neighborhood Hits	102	Shared Neighborhood Hits	59
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

ASCL3_HUMAN
NC score	0.428639 (rank : 25)	θ value	0.0252991 (rank : 36)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

LYL1_HUMAN
NC score	0.426637 (rank : 26)	θ value	0.00102713 (rank : 19)
Query Neighborhood Hits	100	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

SCX_MOUSE
NC score	0.401567 (rank : 27)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	100	Target Neighborhood Hits	82	Shared Neighborhood Hits	53
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

HAND2_HUMAN
NC score	0.397732 (rank : 28)	θ value	0.0148317 (rank : 32)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.397732 (rank : 29)	θ value	0.0148317 (rank : 33)
Query Neighborhood Hits	100	Target Neighborhood Hits	99	Shared Neighborhood Hits	59
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

BHLH8_HUMAN
NC score	0.396835 (rank : 30)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	66
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN1_MOUSE
NC score	0.395509 (rank : 31)	θ value	0.00102713 (rank : 20)
Query Neighborhood Hits	100	Target Neighborhood Hits	87	Shared Neighborhood Hits	51
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

NGN3_MOUSE
NC score	0.394350 (rank : 32)	θ value	0.00175202 (rank : 24)
Query Neighborhood Hits	100	Target Neighborhood Hits	90	Shared Neighborhood Hits	53
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

BHLH8_MOUSE
NC score	0.391885 (rank : 33)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN1_HUMAN
NC score	0.391611 (rank : 34)	θ value	0.00134147 (rank : 22)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	51
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

NGN3_HUMAN
NC score	0.377704 (rank : 35)	θ value	0.0252991 (rank : 37)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

HAND1_MOUSE
NC score	0.373566 (rank : 36)	θ value	0.0113563 (rank : 31)
Query Neighborhood Hits	100	Target Neighborhood Hits	107	Shared Neighborhood Hits	53
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

TCF15_MOUSE
NC score	0.369950 (rank : 37)	θ value	0.00175202 (rank : 25)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	51
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

HAND1_HUMAN
NC score	0.356914 (rank : 38)	θ value	0.125558 (rank : 53)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	53
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

NGN2_HUMAN
NC score	0.348117 (rank : 39)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	100	Target Neighborhood Hits	92	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN2_MOUSE
NC score	0.347666 (rank : 40)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	100	Target Neighborhood Hits	106	Shared Neighborhood Hits	49
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

NDF2_HUMAN
NC score	0.340235 (rank : 41)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	100	Target Neighborhood Hits	113	Shared Neighborhood Hits	57
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
NC score	0.340213 (rank : 42)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	100	Target Neighborhood Hits	111	Shared Neighborhood Hits	58
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

TAL2_HUMAN
NC score	0.325025 (rank : 43)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	46
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

TAL2_MOUSE
NC score	0.324150 (rank : 44)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	47
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

NDF4_MOUSE
NC score	0.324082 (rank : 45)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	100	Target Neighborhood Hits	105	Shared Neighborhood Hits	57
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

NDF1_HUMAN
NC score	0.323415 (rank : 46)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	100	Target Neighborhood Hits	186	Shared Neighborhood Hits	55
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

NDF4_HUMAN
NC score	0.323349 (rank : 47)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	100	Target Neighborhood Hits	91	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

NDF1_MOUSE
NC score	0.321584 (rank : 48)	θ value	0.0330416 (rank : 42)
Query Neighborhood Hits	100	Target Neighborhood Hits	209	Shared Neighborhood Hits	57
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

TCF15_HUMAN
NC score	0.315400 (rank : 49)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	100	Target Neighborhood Hits	79	Shared Neighborhood Hits	49
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

TFAP4_HUMAN
NC score	0.306159 (rank : 50)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	100	Target Neighborhood Hits	289	Shared Neighborhood Hits	50
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

HEN1_HUMAN
NC score	0.298030 (rank : 51)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	100	Target Neighborhood Hits	88	Shared Neighborhood Hits	51
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
NC score	0.295472 (rank : 52)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	100	Target Neighborhood Hits	86	Shared Neighborhood Hits	51
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
NC score	0.285973 (rank : 53)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
NC score	0.284861 (rank : 54)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

ATOH1_MOUSE
NC score	0.258348 (rank : 55)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	100	Target Neighborhood Hits	100	Shared Neighborhood Hits	55
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

ATOH1_HUMAN
NC score	0.251765 (rank : 56)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	53
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

MUSC_MOUSE
NC score	0.244122 (rank : 57)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

MUSC_HUMAN
NC score	0.240016 (rank : 58)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

NDF6_HUMAN
NC score	0.237306 (rank : 59)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	100	Target Neighborhood Hits	91	Shared Neighborhood Hits	50
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
NC score	0.236262 (rank : 60)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	100	Target Neighborhood Hits	95	Shared Neighborhood Hits	50
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

TCF21_HUMAN
NC score	0.235285 (rank : 61)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	100	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

TCF21_MOUSE
NC score	0.234046 (rank : 62)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	100	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

TFE2_HUMAN
NC score	0.227385 (rank : 63)	θ value	0.00869519 (rank : 30)
Query Neighborhood Hits	100	Target Neighborhood Hits	161	Shared Neighborhood Hits	34
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

HTF4_MOUSE
NC score	0.211937 (rank : 64)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	100	Target Neighborhood Hits	153	Shared Neighborhood Hits	38
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

TFE2_MOUSE
NC score	0.211630 (rank : 65)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	100	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

ITF2_HUMAN
NC score	0.205454 (rank : 66)	θ value	0.0961366 (rank : 51)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	36
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
NC score	0.205233 (rank : 67)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	100	Target Neighborhood Hits	154	Shared Neighborhood Hits	36
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

HTF4_HUMAN
NC score	0.204368 (rank : 68)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	100	Target Neighborhood Hits	152	Shared Neighborhood Hits	37
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

ID1_HUMAN
NC score	0.203476 (rank : 69)	θ value	0.125558 (rank : 54)
Query Neighborhood Hits	100	Target Neighborhood Hits	63	Shared Neighborhood Hits	40
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

MNT_MOUSE
NC score	0.202725 (rank : 70)	θ value	0.0330416 (rank : 40)
Query Neighborhood Hits	100	Target Neighborhood Hits	432	Shared Neighborhood Hits	40
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_HUMAN
NC score	0.195534 (rank : 71)	θ value	0.0330416 (rank : 39)
Query Neighborhood Hits	100	Target Neighborhood Hits	496	Shared Neighborhood Hits	40
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

BHLH4_HUMAN
NC score	0.190497 (rank : 72)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	100	Target Neighborhood Hits	70	Shared Neighborhood Hits	41
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

BHLH4_MOUSE
NC score	0.184740 (rank : 73)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	100	Target Neighborhood Hits	71	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

OLIG1_HUMAN
NC score	0.171656 (rank : 74)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	100	Target Neighborhood Hits	85	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

MYC_MOUSE
NC score	0.170834 (rank : 75)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

OLIG2_HUMAN
NC score	0.169667 (rank : 76)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	100	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

OLIG2_MOUSE
NC score	0.168999 (rank : 77)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	100	Target Neighborhood Hits	74	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG1_MOUSE
NC score	0.168106 (rank : 78)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	100	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

ID4_HUMAN
NC score	0.162540 (rank : 79)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	100	Target Neighborhood Hits	67	Shared Neighborhood Hits	43
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

OLIG3_MOUSE
NC score	0.162395 (rank : 80)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	100	Target Neighborhood Hits	76	Shared Neighborhood Hits	37
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

OLIG3_HUMAN
NC score	0.160734 (rank : 81)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	100	Target Neighborhood Hits	77	Shared Neighborhood Hits	37
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

ID4_MOUSE
NC score	0.158112 (rank : 82)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	100	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID1_MOUSE
NC score	0.140133 (rank : 83)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	100	Target Neighborhood Hits	64	Shared Neighborhood Hits	40
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

MYC_HUMAN
NC score	0.133339 (rank : 84)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

HES1_MOUSE
NC score	0.114725 (rank : 85)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	100	Target Neighborhood Hits	78	Shared Neighborhood Hits	14
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.114636 (rank : 86)	θ value	0.21417 (rank : 59)
Query Neighborhood Hits	100	Target Neighborhood Hits	76	Shared Neighborhood Hits	14
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

MAX_MOUSE
NC score	0.109453 (rank : 87)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	100	Target Neighborhood Hits	139	Shared Neighborhood Hits	28
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.102553 (rank : 88)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

ID2_HUMAN
NC score	0.090633 (rank : 89)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	100	Target Neighborhood Hits	48	Shared Neighborhood Hits	32
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

ID2_MOUSE
NC score	0.084435 (rank : 90)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	100	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

HES4_HUMAN
NC score	0.081039 (rank : 91)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	100	Target Neighborhood Hits	58	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MYCS_MOUSE
NC score	0.077644 (rank : 92)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	100	Target Neighborhood Hits	83	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYCN_HUMAN
NC score	0.076824 (rank : 93)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	100	Target Neighborhood Hits	127	Shared Neighborhood Hits	35
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
NC score	0.076754 (rank : 94)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	100	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

HES6_HUMAN
NC score	0.074972 (rank : 95)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	100	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES2_MOUSE
NC score	0.069858 (rank : 96)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	100	Target Neighborhood Hits	36	Shared Neighborhood Hits	13
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_MOUSE
NC score	0.068316 (rank : 97)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	100	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

MYCL1_HUMAN
NC score	0.059932 (rank : 98)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	100	Target Neighborhood Hits	146	Shared Neighborhood Hits	37
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
NC score	0.054799 (rank : 99)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	100	Target Neighborhood Hits	123	Shared Neighborhood Hits	29
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

BAT3_MOUSE
NC score	0.041186 (rank : 100)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	100	Target Neighborhood Hits	518	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

ATF6B_MOUSE
NC score	0.036683 (rank : 101)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	100	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

MARCS_MOUSE
NC score	0.036249 (rank : 102)	θ value	0.813845 (rank : 65)
Query Neighborhood Hits	100	Target Neighborhood Hits	227	Shared Neighborhood Hits	7
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

TF3C2_HUMAN
NC score	0.033308 (rank : 103)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	100	Target Neighborhood Hits	168	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WUA4, Q16632, Q9BWI7	Gene names	GTF3C2, KIAA0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

GNAS1_MOUSE
NC score	0.032769 (rank : 104)	θ value	0.00228821 (rank : 26)
Query Neighborhood Hits	100	Target Neighborhood Hits	651	Shared Neighborhood Hits	15
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

TF3C2_MOUSE
NC score	0.031008 (rank : 105)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	100	Target Neighborhood Hits	165	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BL74, Q3U7Z9, Q80XQ7, Q8BJJ4, Q8BLP3, Q8K1J1, Q9CSS0, Q9CVE6, Q9DBK6	Gene names	Gtf3c2, Kiaa0011
Domain Architecture
Description	General transcription factor 3C polypeptide 2 (Transcription factor IIIC-subunit beta) (TF3C-beta) (TFIIIC 110 kDa subunit) (TFIIIC110).

OGFR_HUMAN
NC score	0.030874 (rank : 106)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	100	Target Neighborhood Hits	1582	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

TTLL5_MOUSE
NC score	0.029773 (rank : 107)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	100	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

TTLL5_HUMAN
NC score	0.027034 (rank : 108)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	100	Target Neighborhood Hits	141	Shared Neighborhood Hits	4
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

PRRT3_HUMAN
NC score	0.026699 (rank : 109)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	100	Target Neighborhood Hits	998	Shared Neighborhood Hits	26
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CCNK_MOUSE
NC score	0.021275 (rank : 110)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	100	Target Neighborhood Hits	350	Shared Neighborhood Hits	12
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

MAGC1_HUMAN
NC score	0.021234 (rank : 111)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	100	Target Neighborhood Hits	431	Shared Neighborhood Hits	7
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

CI005_HUMAN
NC score	0.019141 (rank : 112)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	100	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H330, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6	Gene names	C9orf5
Domain Architecture	No domain graphic available
Description	Protein C9orf5 (Protein CG-2).

PRP2_MOUSE
NC score	0.018807 (rank : 113)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	100	Target Neighborhood Hits	347	Shared Neighborhood Hits	7
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

TARA_MOUSE
NC score	0.018622 (rank : 114)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	100	Target Neighborhood Hits	1133	Shared Neighborhood Hits	18
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PDC6I_MOUSE
NC score	0.016845 (rank : 115)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	100	Target Neighborhood Hits	275	Shared Neighborhood Hits	8
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

NOLC1_HUMAN
NC score	0.015567 (rank : 116)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	100	Target Neighborhood Hits	452	Shared Neighborhood Hits	7
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

RUSC1_HUMAN
NC score	0.014747 (rank : 117)	θ value	4.03905 (rank : 81)
Query Neighborhood Hits	100	Target Neighborhood Hits	226	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

MYOM1_MOUSE
NC score	0.014318 (rank : 118)	θ value	0.813845 (rank : 66)
Query Neighborhood Hits	100	Target Neighborhood Hits	415	Shared Neighborhood Hits	4
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

RFX1_MOUSE
NC score	0.012821 (rank : 119)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	100	Target Neighborhood Hits	181	Shared Neighborhood Hits	7
SwissProt Accessions	P48377	Gene names	Rfx1
Domain Architecture
Description	DNA-binding protein RFX1.

EVL_HUMAN
NC score	0.009215 (rank : 120)	θ value	8.99809 (rank : 96)
Query Neighborhood Hits	100	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

PTN23_MOUSE
NC score	0.008747 (rank : 121)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	100	Target Neighborhood Hits	726	Shared Neighborhood Hits	11
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SHAN1_HUMAN
NC score	0.008676 (rank : 122)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	100	Target Neighborhood Hits	1041	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SOS1_MOUSE
NC score	0.008260 (rank : 123)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	100	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ARHG2_HUMAN
NC score	0.006872 (rank : 124)	θ value	6.88961 (rank : 89)
Query Neighborhood Hits	100	Target Neighborhood Hits	142	Shared Neighborhood Hits	2
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

NRG2_HUMAN
NC score	0.004561 (rank : 125)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	100	Target Neighborhood Hits	419	Shared Neighborhood Hits	3
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

R4RL2_MOUSE
NC score	0.004546 (rank : 126)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	100	Target Neighborhood Hits	279	Shared Neighborhood Hits	3
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

TSP1_MOUSE
NC score	0.003832 (rank : 127)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	100	Target Neighborhood Hits	396	Shared Neighborhood Hits	3
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

R4RL2_HUMAN
NC score	0.003407 (rank : 128)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	100	Target Neighborhood Hits	273	Shared Neighborhood Hits	3
SwissProt Accessions	Q86UN3, Q6X813	Gene names	RTN4RL2, NGRH1, NGRL3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

FOG1_MOUSE
NC score	0.002754 (rank : 129)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	100	Target Neighborhood Hits	1237	Shared Neighborhood Hits	15
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

WNK2_HUMAN
NC score	-0.000772 (rank : 130)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	100	Target Neighborhood Hits	1407	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).