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Network neighborhood for query Sequence : HPS4_HUMAN

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HPS4_HUMAN
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HPS4_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

HPS4_MOUSE
θ value	0 (rank : 2)	NC score	0.954070 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KG7	Gene names	Hps4, Le
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein homolog (Light-ear protein) (Le protein).

KCND3_HUMAN
θ value	0.163984 (rank : 3)	NC score	0.032232 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.279714 (rank : 4)	NC score	0.031075 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

NCOA6_HUMAN
θ value	0.62314 (rank : 5)	NC score	0.040571 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	1202	Shared Neighborhood Hits	15
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

PO6F2_HUMAN
θ value	0.62314 (rank : 6)	NC score	0.029836 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	618	Shared Neighborhood Hits	10
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

SOX13_MOUSE
θ value	0.62314 (rank : 7)	NC score	0.025614 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	495	Shared Neighborhood Hits	6
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

K1958_MOUSE
θ value	0.813845 (rank : 8)	NC score	0.043581 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C4P0, Q8BN62, Q8K1X8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1958 homolog.

RTN1_MOUSE
θ value	1.06291 (rank : 9)	NC score	0.031703 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SEN34_MOUSE
θ value	1.06291 (rank : 10)	NC score	0.045697 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	158	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

DYN1_HUMAN
θ value	1.38821 (rank : 11)	NC score	0.031233 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_MOUSE
θ value	1.38821 (rank : 12)	NC score	0.031274 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

MPDZ_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.015767 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

GOG8A_HUMAN
θ value	2.36792 (rank : 14)	NC score	0.017699 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	635	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

ZN447_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.007017 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	899	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

EFS_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.020706 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	389	Shared Neighborhood Hits	3
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ZN395_HUMAN
θ value	3.0926 (rank : 17)	NC score	0.039138 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H8N7, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59	Gene names	ZNF395, HDBP2, PBF
Domain Architecture	No domain graphic available
Description	Zinc finger protein 395 (Papillomavirus-binding factor) (Papillomavirus regulatory factor 1) (PRF-1) (Huntington disease gene regulatory region-binding protein 2) (HDBP-2) (HD gene regulatory region-binding protein 2) (HD-regulating factor 2) (HDRF-2).

HAPIP_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.013460 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	3
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

EPIPL_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.016118 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

MDC1_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.023429 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	998	Shared Neighborhood Hits	10
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MGR4_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.016339 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q14833, Q5SZ84	Gene names	GRM4, GPRC1D, MGLUR4
Domain Architecture
Description	Metabotropic glutamate receptor 4 precursor (mGluR4).

MGR7_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.016670 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q14831, Q8NFS2, Q8NFS3, Q8NFS4	Gene names	GRM7, GPRC1G, MGLUR7
Domain Architecture
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR7_MOUSE
θ value	5.27518 (rank : 23)	NC score	0.016679 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q68ED2	Gene names	Grm7, Gprc1g, Mglur7
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

PO6F2_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.023489 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	639	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

TARSH_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.020550 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	768	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

COFA1_HUMAN
θ value	6.88961 (rank : 26)	NC score	0.009367 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	292	Shared Neighborhood Hits	3
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

EVX1_HUMAN
θ value	6.88961 (rank : 27)	NC score	0.009741 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	349	Shared Neighborhood Hits	5
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

EXT2_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.018715 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXT2_MOUSE
θ value	6.88961 (rank : 29)	NC score	0.018599 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

K0427_MOUSE
θ value	6.88961 (rank : 30)	NC score	0.017962 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PEE2	Gene names	Gm672
Domain Architecture	No domain graphic available
Description	Protein KIAA0427 homolog.

PLXA4_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.006880 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q80UG2, Q5DTW8, Q8BKK9	Gene names	Plxna4, Kiaa1550
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

PRG4_HUMAN
θ value	6.88961 (rank : 32)	NC score	0.013591 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RIMS1_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.010564 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

XE7_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.009204 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	738	Shared Neighborhood Hits	4
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

ZEP1_MOUSE
θ value	6.88961 (rank : 35)	NC score	0.005317 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	1063	Shared Neighborhood Hits	5
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

ZIMP7_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.015812 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	290	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

CND2_HUMAN
θ value	8.99809 (rank : 37)	NC score	0.015896 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q15003, Q8TB87	Gene names	NCAPH, BRRN, BRRN1, CAPH, KIAA0074
Domain Architecture
Description	Condensin complex subunit 2 (Non-SMC condensin I complex subunit H) (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (XCAP-H homolog).

CSPG2_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.005300 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	681	Shared Neighborhood Hits	6
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

EVX1_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.008864 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

FOXGB_HUMAN
θ value	8.99809 (rank : 40)	NC score	0.005153 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	P55315	Gene names	FOXG1B, FKHL1
Domain Architecture
Description	Forkhead box protein G1B (Forkhead-related protein FKHL1) (Transcription factor BF-1) (Brain factor 1) (BF1) (HFK1).

M3K12_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.000186 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	957	Shared Neighborhood Hits	2
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

NPAS1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.007980 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

R3HD2_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.018994 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

Hits sorted by NC score

HPS4_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	43	Target Neighborhood Hits	43	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NQG7, Q5H8V6, Q96LX6, Q9BY93, Q9UH37, Q9UH38	Gene names	HPS4, KIAA1667
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein (Light-ear protein homolog).

HPS4_MOUSE
NC score	0.954070 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	43	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KG7	Gene names	Hps4, Le
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 4 protein homolog (Light-ear protein) (Le protein).

SEN34_MOUSE
NC score	0.045697 (rank : 3)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	43	Target Neighborhood Hits	158	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BMZ5, Q58EU2, Q99LV6, Q9CYW1	Gene names	Tsen34, Leng5, Sen34
Domain Architecture	No domain graphic available
Description	tRNA-splicing endonuclease subunit Sen34 (EC 3.1.27.9) (tRNA-intron endonuclease Sen34) (Leukocyte receptor cluster member 5 homolog).

K1958_MOUSE
NC score	0.043581 (rank : 4)	θ value	0.813845 (rank : 8)
Query Neighborhood Hits	43	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q8C4P0, Q8BN62, Q8K1X8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1958 homolog.

NCOA6_HUMAN
NC score	0.040571 (rank : 5)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	43	Target Neighborhood Hits	1202	Shared Neighborhood Hits	15
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ZN395_HUMAN
NC score	0.039138 (rank : 6)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	43	Target Neighborhood Hits	64	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H8N7, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59	Gene names	ZNF395, HDBP2, PBF
Domain Architecture	No domain graphic available
Description	Zinc finger protein 395 (Papillomavirus-binding factor) (Papillomavirus regulatory factor 1) (PRF-1) (Huntington disease gene regulatory region-binding protein 2) (HDBP-2) (HD gene regulatory region-binding protein 2) (HD-regulating factor 2) (HDRF-2).

KCND3_HUMAN
NC score	0.032232 (rank : 7)	θ value	0.163984 (rank : 3)
Query Neighborhood Hits	43	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

RTN1_MOUSE
NC score	0.031703 (rank : 8)	θ value	1.06291 (rank : 9)
Query Neighborhood Hits	43	Target Neighborhood Hits	189	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

DYN1_MOUSE
NC score	0.031274 (rank : 9)	θ value	1.38821 (rank : 12)
Query Neighborhood Hits	43	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
NC score	0.031233 (rank : 10)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	43	Target Neighborhood Hits	216	Shared Neighborhood Hits	5
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

KCND3_MOUSE
NC score	0.031075 (rank : 11)	θ value	0.279714 (rank : 4)
Query Neighborhood Hits	43	Target Neighborhood Hits	162	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

PO6F2_HUMAN
NC score	0.029836 (rank : 12)	θ value	0.62314 (rank : 6)
Query Neighborhood Hits	43	Target Neighborhood Hits	618	Shared Neighborhood Hits	10
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

SOX13_MOUSE
NC score	0.025614 (rank : 13)	θ value	0.62314 (rank : 7)
Query Neighborhood Hits	43	Target Neighborhood Hits	495	Shared Neighborhood Hits	6
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

PO6F2_MOUSE
NC score	0.023489 (rank : 14)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	43	Target Neighborhood Hits	639	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

MDC1_MOUSE
NC score	0.023429 (rank : 15)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	43	Target Neighborhood Hits	998	Shared Neighborhood Hits	10
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

EFS_MOUSE
NC score	0.020706 (rank : 16)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	43	Target Neighborhood Hits	389	Shared Neighborhood Hits	3
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

TARSH_HUMAN
NC score	0.020550 (rank : 17)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	43	Target Neighborhood Hits	768	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

R3HD2_MOUSE
NC score	0.018994 (rank : 18)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	43	Target Neighborhood Hits	397	Shared Neighborhood Hits	6
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

EXT2_HUMAN
NC score	0.018715 (rank : 19)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	43	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q93063, O15288	Gene names	EXT2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Putative tumor suppressor protein EXT2) (Multiple exostoses protein 2).

EXT2_MOUSE
NC score	0.018599 (rank : 20)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	43	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	P70428, P70395, Q923D6	Gene names	Ext2
Domain Architecture
Description	Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N- acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4- alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2 homolog).

K0427_MOUSE
NC score	0.017962 (rank : 21)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	43	Target Neighborhood Hits	106	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PEE2	Gene names	Gm672
Domain Architecture	No domain graphic available
Description	Protein KIAA0427 homolog.

GOG8A_HUMAN
NC score	0.017699 (rank : 22)	θ value	2.36792 (rank : 14)
Query Neighborhood Hits	43	Target Neighborhood Hits	635	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

MGR7_MOUSE
NC score	0.016679 (rank : 23)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	43	Target Neighborhood Hits	53	Shared Neighborhood Hits	4
SwissProt Accessions	Q68ED2	Gene names	Grm7, Gprc1g, Mglur7
Domain Architecture	No domain graphic available
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR7_HUMAN
NC score	0.016670 (rank : 24)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	43	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	Q14831, Q8NFS2, Q8NFS3, Q8NFS4	Gene names	GRM7, GPRC1G, MGLUR7
Domain Architecture
Description	Metabotropic glutamate receptor 7 precursor (mGluR7).

MGR4_HUMAN
NC score	0.016339 (rank : 25)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	43	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q14833, Q5SZ84	Gene names	GRM4, GPRC1D, MGLUR4
Domain Architecture
Description	Metabotropic glutamate receptor 4 precursor (mGluR4).

EPIPL_HUMAN
NC score	0.016118 (rank : 26)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	43	Target Neighborhood Hits	73	Shared Neighborhood Hits	4
SwissProt Accessions	P58107, Q76E58	Gene names	EPPK1, EPIPL
Domain Architecture
Description	Epiplakin (450 kDa epidermal antigen).

CND2_HUMAN
NC score	0.015896 (rank : 27)	θ value	8.99809 (rank : 37)
Query Neighborhood Hits	43	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q15003, Q8TB87	Gene names	NCAPH, BRRN, BRRN1, CAPH, KIAA0074
Domain Architecture
Description	Condensin complex subunit 2 (Non-SMC condensin I complex subunit H) (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (XCAP-H homolog).

ZIMP7_HUMAN
NC score	0.015812 (rank : 28)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	43	Target Neighborhood Hits	290	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

MPDZ_HUMAN
NC score	0.015767 (rank : 29)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	43	Target Neighborhood Hits	261	Shared Neighborhood Hits	3
SwissProt Accessions	O75970, O43798, Q5CZ80, Q5JTX3, Q5JTX6, Q5JTX7, Q5JUC3, Q5JUC4, Q5VZ62, Q8N790	Gene names	MPDZ, MUPP1
Domain Architecture	No domain graphic available
Description	Multiple PDZ domain protein (Multi PDZ domain protein 1) (Multi-PDZ- domain protein 1).

PRG4_HUMAN
NC score	0.013591 (rank : 30)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	43	Target Neighborhood Hits	764	Shared Neighborhood Hits	8
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

HAPIP_HUMAN
NC score	0.013460 (rank : 31)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	3
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

RIMS1_HUMAN
NC score	0.010564 (rank : 32)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	43	Target Neighborhood Hits	437	Shared Neighborhood Hits	6
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

EVX1_HUMAN
NC score	0.009741 (rank : 33)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	43	Target Neighborhood Hits	349	Shared Neighborhood Hits	5
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

COFA1_HUMAN
NC score	0.009367 (rank : 34)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	43	Target Neighborhood Hits	292	Shared Neighborhood Hits	3
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

XE7_HUMAN
NC score	0.009204 (rank : 35)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	43	Target Neighborhood Hits	738	Shared Neighborhood Hits	4
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

EVX1_MOUSE
NC score	0.008864 (rank : 36)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	43	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

NPAS1_HUMAN
NC score	0.007980 (rank : 37)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	43	Target Neighborhood Hits	77	Shared Neighborhood Hits	2
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

ZN447_HUMAN
NC score	0.007017 (rank : 38)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	43	Target Neighborhood Hits	899	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TBC5, Q9BRK7, Q9H9A0	Gene names	ZNF447
Domain Architecture	No domain graphic available
Description	Zinc finger protein 447.

PLXA4_MOUSE
NC score	0.006880 (rank : 39)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	43	Target Neighborhood Hits	109	Shared Neighborhood Hits	2
SwissProt Accessions	Q80UG2, Q5DTW8, Q8BKK9	Gene names	Plxna4, Kiaa1550
Domain Architecture	No domain graphic available
Description	Plexin-A4 precursor.

ZEP1_MOUSE
NC score	0.005317 (rank : 40)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	43	Target Neighborhood Hits	1063	Shared Neighborhood Hits	5
SwissProt Accessions	Q03172	Gene names	Hivep1, Cryabp1, Znf40
Domain Architecture
Description	Zinc finger protein 40 (Transcription factor alphaA-CRYBP1) (Alpha A- crystallin-binding protein I) (Alpha A-CRYBP1).

CSPG2_HUMAN
NC score	0.005300 (rank : 41)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	43	Target Neighborhood Hits	681	Shared Neighborhood Hits	6
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

FOXGB_HUMAN
NC score	0.005153 (rank : 42)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	43	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	P55315	Gene names	FOXG1B, FKHL1
Domain Architecture
Description	Forkhead box protein G1B (Forkhead-related protein FKHL1) (Transcription factor BF-1) (Brain factor 1) (BF1) (HFK1).

M3K12_MOUSE
NC score	0.000186 (rank : 43)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	43	Target Neighborhood Hits	957	Shared Neighborhood Hits	2
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).