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Network neighborhood for query Sequence : ATR_HUMAN

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ATR_HUMAN
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATR_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	0 (rank : 2)	NC score	0.996814 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	63	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_MOUSE
θ value	2.23575e-83 (rank : 3)	NC score	0.800833 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	33
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATM_HUMAN
θ value	1.7238e-59 (rank : 4)	NC score	0.794003 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

FRAP_MOUSE
θ value	3.84914e-51 (rank : 5)	NC score	0.765309 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
θ value	1.91031e-50 (rank : 6)	NC score	0.763938 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_MOUSE
θ value	4.40402e-47 (rank : 7)	NC score	0.714042 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	212	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
θ value	5.7518e-47 (rank : 8)	NC score	0.708641 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PRKDC_HUMAN
θ value	9.83387e-39 (rank : 9)	NC score	0.693285 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PRKDC_MOUSE
θ value	1.57e-36 (rank : 10)	NC score	0.696522 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

TRRAP_MOUSE
θ value	8.65492e-19 (rank : 11)	NC score	0.477974 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
θ value	1.13037e-18 (rank : 12)	NC score	0.468437 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	117	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3C3_MOUSE
θ value	3.29651e-10 (rank : 13)	NC score	0.464131 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
θ value	1.25267e-09 (rank : 14)	NC score	0.461052 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3CG_MOUSE
θ value	1.53129e-07 (rank : 15)	NC score	0.368325 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_HUMAN
θ value	3.41135e-07 (rank : 16)	NC score	0.369032 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CB_HUMAN
θ value	1.09739e-05 (rank : 17)	NC score	0.367675 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	1.09739e-05 (rank : 18)	NC score	0.367773 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

P3C2A_HUMAN
θ value	1.87187e-05 (rank : 19)	NC score	0.286253 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2A_MOUSE
θ value	1.87187e-05 (rank : 20)	NC score	0.288660 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

PI4KB_HUMAN
θ value	2.44474e-05 (rank : 21)	NC score	0.376881 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PK3CD_HUMAN
θ value	2.44474e-05 (rank : 22)	NC score	0.358702 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_MOUSE
θ value	2.44474e-05 (rank : 23)	NC score	0.359761 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	30
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PI4KB_MOUSE
θ value	3.19293e-05 (rank : 24)	NC score	0.373726 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

P3C2G_MOUSE
θ value	0.000270298 (rank : 25)	NC score	0.324750 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
θ value	0.000461057 (rank : 26)	NC score	0.333679 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2G_HUMAN
θ value	0.000602161 (rank : 27)	NC score	0.316835 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CA_HUMAN
θ value	0.00175202 (rank : 28)	NC score	0.321949 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
θ value	0.00175202 (rank : 29)	NC score	0.321687 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2B_HUMAN
θ value	0.0252991 (rank : 30)	NC score	0.255712 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

NR5A2_MOUSE
θ value	0.0736092 (rank : 31)	NC score	0.025852 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

CAND1_HUMAN
θ value	0.0961366 (rank : 32)	NC score	0.064651 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

CAND1_MOUSE
θ value	0.21417 (rank : 33)	NC score	0.060458 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

SYYC_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.037522 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

CF152_MOUSE
θ value	1.06291 (rank : 35)	NC score	0.029634 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	597	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

MDN1_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.019373 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	662	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SYYC_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.034088 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

TBL3_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.013778 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

ABCC8_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.011167 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q09428, O75948, Q16583	Gene names	ABCC8, SUR, SUR1
Domain Architecture
Description	ATP-binding cassette transporter sub-family C member 8 (Sulfonylurea receptor 1).

CF152_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.017758 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	704	Shared Neighborhood Hits	10
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CTND1_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.011437 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

MK12_HUMAN
θ value	3.0926 (rank : 42)	NC score	-0.000285 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	830	Shared Neighborhood Hits	7
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

SYNE1_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.009957 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	1484	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

TTBK2_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.009157 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	822	Shared Neighborhood Hits	8
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

ALS2_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.015016 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

CCD46_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.008135 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	1430	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

INSC_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.016766 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q1MX18, Q1MX19, Q3C1V6, Q4AC95, Q4AC96, Q4AC97, Q4AC98	Gene names	INSC
Domain Architecture	No domain graphic available
Description	Protein inscuteable homolog.

KIFA3_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.025892 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q92845, Q8NHU7, Q9H416	Gene names	KIFAP3, SMAP
Domain Architecture
Description	Kinesin-associated protein 3 (Smg GDS-associated protein).

PSMD2_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.019478 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q13200, Q12932, Q15321, Q96I12	Gene names	PSMD2, TRAP2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor- associated protein 2) (55.11 protein).

TCF25_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.016201 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

TCRG1_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.019159 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	929	Shared Neighborhood Hits	14
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.015233 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	947	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

UBD_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.035689 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P63072, Q9WV10	Gene names	Ubd, Fat10
Domain Architecture	No domain graphic available
Description	Ubiquitin D (Ubiquitin-like protein FAT10) (Diubiquitin).

ULK4_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.000722 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	793	Shared Neighborhood Hits	8
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

ALS2_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.013993 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

CP250_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.005526 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	1583	Shared Neighborhood Hits	15
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

ICAM1_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.009522 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

PARVG_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.015465 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

STK36_HUMAN
θ value	5.27518 (rank : 59)	NC score	-0.001099 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	896	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

GATB_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.012325 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	O75879, Q9P0S6, Q9Y2B8	Gene names	PET112L, PET112
Domain Architecture
Description	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial precursor (EC 6.3.5.-) (Glu-ADT subunit B) (Cytochrome oxidase assembly factor PET112 homolog).

PDE6C_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.006777 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PSMD2_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.017455 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

SMC2_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.012542 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	1405	Shared Neighborhood Hits	18
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

ANR32_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.003182 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	285	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

CTND1_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.008830 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

GCN1L_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.037719 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	9
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

GOGA4_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.008136 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	1939	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

NEK1_MOUSE
θ value	8.99809 (rank : 68)	NC score	-0.001659 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	1311	Shared Neighborhood Hits	13
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

SMC2_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.013215 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	1131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SORT_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.006091 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

TTBK2_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.003375 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

Hits sorted by NC score

ATR_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	71	Target Neighborhood Hits	71	Shared Neighborhood Hits	71
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.996814 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	71	Target Neighborhood Hits	63	Shared Neighborhood Hits	45
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_MOUSE
NC score	0.800833 (rank : 3)	θ value	2.23575e-83 (rank : 3)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	33
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

ATM_HUMAN
NC score	0.794003 (rank : 4)	θ value	1.7238e-59 (rank : 4)
Query Neighborhood Hits	71	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

FRAP_MOUSE
NC score	0.765309 (rank : 5)	θ value	3.84914e-51 (rank : 5)
Query Neighborhood Hits	71	Target Neighborhood Hits	77	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_HUMAN
NC score	0.763938 (rank : 6)	θ value	1.91031e-50 (rank : 6)
Query Neighborhood Hits	71	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_MOUSE
NC score	0.714042 (rank : 7)	θ value	4.40402e-47 (rank : 7)
Query Neighborhood Hits	71	Target Neighborhood Hits	212	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.708641 (rank : 8)	θ value	5.7518e-47 (rank : 8)
Query Neighborhood Hits	71	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

PRKDC_MOUSE
NC score	0.696522 (rank : 9)	θ value	1.57e-36 (rank : 10)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.693285 (rank : 10)	θ value	9.83387e-39 (rank : 9)
Query Neighborhood Hits	71	Target Neighborhood Hits	93	Shared Neighborhood Hits	30
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

TRRAP_MOUSE
NC score	0.477974 (rank : 11)	θ value	8.65492e-19 (rank : 11)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
NC score	0.468437 (rank : 12)	θ value	1.13037e-18 (rank : 12)
Query Neighborhood Hits	71	Target Neighborhood Hits	117	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3C3_MOUSE
NC score	0.464131 (rank : 13)	θ value	3.29651e-10 (rank : 13)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3C3_HUMAN
NC score	0.461052 (rank : 14)	θ value	1.25267e-09 (rank : 14)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PI4KB_HUMAN
NC score	0.376881 (rank : 15)	θ value	2.44474e-05 (rank : 21)
Query Neighborhood Hits	71	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.373726 (rank : 16)	θ value	3.19293e-05 (rank : 24)
Query Neighborhood Hits	71	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PK3CG_HUMAN
NC score	0.369032 (rank : 17)	θ value	3.41135e-07 (rank : 16)
Query Neighborhood Hits	71	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.368325 (rank : 18)	θ value	1.53129e-07 (rank : 15)
Query Neighborhood Hits	71	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CB_MOUSE
NC score	0.367773 (rank : 19)	θ value	1.09739e-05 (rank : 18)
Query Neighborhood Hits	71	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.367675 (rank : 20)	θ value	1.09739e-05 (rank : 17)
Query Neighborhood Hits	71	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CD_MOUSE
NC score	0.359761 (rank : 21)	θ value	2.44474e-05 (rank : 23)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	30
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
NC score	0.358702 (rank : 22)	θ value	2.44474e-05 (rank : 22)
Query Neighborhood Hits	71	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PI4KA_HUMAN
NC score	0.333679 (rank : 23)	θ value	0.000461057 (rank : 26)
Query Neighborhood Hits	71	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2G_MOUSE
NC score	0.324750 (rank : 24)	θ value	0.000270298 (rank : 25)
Query Neighborhood Hits	71	Target Neighborhood Hits	113	Shared Neighborhood Hits	28
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CA_HUMAN
NC score	0.321949 (rank : 25)	θ value	0.00175202 (rank : 28)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.321687 (rank : 26)	θ value	0.00175202 (rank : 29)
Query Neighborhood Hits	71	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_HUMAN
NC score	0.316835 (rank : 27)	θ value	0.000602161 (rank : 27)
Query Neighborhood Hits	71	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
NC score	0.288660 (rank : 28)	θ value	1.87187e-05 (rank : 20)
Query Neighborhood Hits	71	Target Neighborhood Hits	181	Shared Neighborhood Hits	28
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.286253 (rank : 29)	θ value	1.87187e-05 (rank : 19)
Query Neighborhood Hits	71	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.255712 (rank : 30)	θ value	0.0252991 (rank : 30)
Query Neighborhood Hits	71	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

CAND1_HUMAN
NC score	0.064651 (rank : 31)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	71	Target Neighborhood Hits	45	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

CAND1_MOUSE
NC score	0.060458 (rank : 32)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	71	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

GCN1L_HUMAN
NC score	0.037719 (rank : 33)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	71	Target Neighborhood Hits	112	Shared Neighborhood Hits	9
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

SYYC_HUMAN
NC score	0.037522 (rank : 34)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	71	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	P54577, O43276, Q53EN1	Gene names	YARS
Domain Architecture
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

UBD_MOUSE
NC score	0.035689 (rank : 35)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	71	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	P63072, Q9WV10	Gene names	Ubd, Fat10
Domain Architecture	No domain graphic available
Description	Ubiquitin D (Ubiquitin-like protein FAT10) (Diubiquitin).

SYYC_MOUSE
NC score	0.034088 (rank : 36)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	71	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q91WQ3, Q3TEC8, Q3U9A1, Q3UTA7, Q8BVT2, Q8C183	Gene names	Yars
Domain Architecture	No domain graphic available
Description	Tyrosyl-tRNA synthetase, cytoplasmic (EC 6.1.1.1) (Tyrosyl--tRNA ligase) (TyrRS).

CF152_MOUSE
NC score	0.029634 (rank : 37)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	71	Target Neighborhood Hits	597	Shared Neighborhood Hits	10
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

KIFA3_HUMAN
NC score	0.025892 (rank : 38)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	71	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q92845, Q8NHU7, Q9H416	Gene names	KIFAP3, SMAP
Domain Architecture
Description	Kinesin-associated protein 3 (Smg GDS-associated protein).

NR5A2_MOUSE
NC score	0.025852 (rank : 39)	θ value	0.0736092 (rank : 31)
Query Neighborhood Hits	71	Target Neighborhood Hits	107	Shared Neighborhood Hits	3
SwissProt Accessions	P45448	Gene names	Nr5a2, Lrh1
Domain Architecture
Description	Orphan nuclear receptor NR5A2 (Liver receptor homolog 1) (LRH-1).

PSMD2_HUMAN
NC score	0.019478 (rank : 40)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	71	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	Q13200, Q12932, Q15321, Q96I12	Gene names	PSMD2, TRAP2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97) (Tumor necrosis factor type 1 receptor- associated protein 2) (55.11 protein).

MDN1_HUMAN
NC score	0.019373 (rank : 41)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	71	Target Neighborhood Hits	662	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

TCRG1_HUMAN
NC score	0.019159 (rank : 42)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	71	Target Neighborhood Hits	929	Shared Neighborhood Hits	14
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

CF152_HUMAN
NC score	0.017758 (rank : 43)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	71	Target Neighborhood Hits	704	Shared Neighborhood Hits	10
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

PSMD2_MOUSE
NC score	0.017455 (rank : 44)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	71	Target Neighborhood Hits	147	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VDM4	Gene names	Psmd2
Domain Architecture	No domain graphic available
Description	26S proteasome non-ATPase regulatory subunit 2 (26S proteasome regulatory subunit RPN1) (26S proteasome regulatory subunit S2) (26S proteasome subunit p97).

INSC_HUMAN
NC score	0.016766 (rank : 45)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	71	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q1MX18, Q1MX19, Q3C1V6, Q4AC95, Q4AC96, Q4AC97, Q4AC98	Gene names	INSC
Domain Architecture	No domain graphic available
Description	Protein inscuteable homolog.

TCF25_HUMAN
NC score	0.016201 (rank : 46)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	71	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQ70, Q2MK75, Q9UPV3	Gene names	TCF25, KIAA1049, NULP1
Domain Architecture
Description	Transcription factor 25 (Nuclear localized protein 1).

PARVG_HUMAN
NC score	0.015465 (rank : 47)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	71	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HBI0, Q9BQX5, Q9NSG1	Gene names	PARVG
Domain Architecture
Description	Gamma-parvin.

TCRG1_MOUSE
NC score	0.015233 (rank : 48)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	71	Target Neighborhood Hits	947	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

ALS2_MOUSE
NC score	0.015016 (rank : 49)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	71	Target Neighborhood Hits	111	Shared Neighborhood Hits	4
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

ALS2_HUMAN
NC score	0.013993 (rank : 50)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	71	Target Neighborhood Hits	121	Shared Neighborhood Hits	4
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

TBL3_HUMAN
NC score	0.013778 (rank : 51)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	71	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q12788	Gene names	TBL3, SAZD
Domain Architecture
Description	WD repeat protein SAZD (Transducin beta-like 3 protein).

SMC2_MOUSE
NC score	0.013215 (rank : 52)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	71	Target Neighborhood Hits	1131	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC2_HUMAN
NC score	0.012542 (rank : 53)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	71	Target Neighborhood Hits	1405	Shared Neighborhood Hits	18
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

GATB_HUMAN
NC score	0.012325 (rank : 54)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	71	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	O75879, Q9P0S6, Q9Y2B8	Gene names	PET112L, PET112
Domain Architecture
Description	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial precursor (EC 6.3.5.-) (Glu-ADT subunit B) (Cytochrome oxidase assembly factor PET112 homolog).

CTND1_HUMAN
NC score	0.011437 (rank : 55)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	71	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

ABCC8_HUMAN
NC score	0.011167 (rank : 56)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	71	Target Neighborhood Hits	118	Shared Neighborhood Hits	4
SwissProt Accessions	Q09428, O75948, Q16583	Gene names	ABCC8, SUR, SUR1
Domain Architecture
Description	ATP-binding cassette transporter sub-family C member 8 (Sulfonylurea receptor 1).

SYNE1_HUMAN
NC score	0.009957 (rank : 57)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	71	Target Neighborhood Hits	1484	Shared Neighborhood Hits	15
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ICAM1_MOUSE
NC score	0.009522 (rank : 58)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	71	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

TTBK2_HUMAN
NC score	0.009157 (rank : 59)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	71	Target Neighborhood Hits	822	Shared Neighborhood Hits	8
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

CTND1_MOUSE
NC score	0.008830 (rank : 60)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	71	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

GOGA4_MOUSE
NC score	0.008136 (rank : 61)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	71	Target Neighborhood Hits	1939	Shared Neighborhood Hits	17
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

CCD46_HUMAN
NC score	0.008135 (rank : 62)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	71	Target Neighborhood Hits	1430	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

PDE6C_HUMAN
NC score	0.006777 (rank : 63)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	71	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

SORT_MOUSE
NC score	0.006091 (rank : 64)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	71	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PHU5, Q3UHE2, Q8K043, Q9QXW6	Gene names	Sort1
Domain Architecture	No domain graphic available
Description	Sortilin precursor (Neurotensin receptor 3) (NTR3) (mNTR3).

CP250_MOUSE
NC score	0.005526 (rank : 65)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	71	Target Neighborhood Hits	1583	Shared Neighborhood Hits	15
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

TTBK2_MOUSE
NC score	0.003375 (rank : 66)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	71	Target Neighborhood Hits	811	Shared Neighborhood Hits	7
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ANR32_MOUSE
NC score	0.003182 (rank : 67)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	71	Target Neighborhood Hits	285	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

ULK4_MOUSE
NC score	0.000722 (rank : 68)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	71	Target Neighborhood Hits	793	Shared Neighborhood Hits	8
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

MK12_HUMAN
NC score	-0.000285 (rank : 69)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	71	Target Neighborhood Hits	830	Shared Neighborhood Hits	7
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

STK36_HUMAN
NC score	-0.001099 (rank : 70)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	71	Target Neighborhood Hits	896	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEK1_MOUSE
NC score	-0.001659 (rank : 71)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	71	Target Neighborhood Hits	1311	Shared Neighborhood Hits	13
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).