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Network neighborhood for query Sequence : FRAP_HUMAN

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FRAP_HUMAN
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FRAP_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	83
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
θ value	0 (rank : 2)	NC score	0.999011 (rank : 2)
Query Neighborhood Hits	83	Target Neighborhood Hits	77	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

SMG1_MOUSE
θ value	5.92465e-60 (rank : 3)	NC score	0.740484 (rank : 5)
Query Neighborhood Hits	83	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
θ value	1.01059e-59 (rank : 4)	NC score	0.734174 (rank : 6)
Query Neighborhood Hits	83	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

ATR_HUMAN
θ value	1.91031e-50 (rank : 5)	NC score	0.763938 (rank : 3)
Query Neighborhood Hits	83	Target Neighborhood Hits	71	Shared Neighborhood Hits	34
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
θ value	8.02596e-49 (rank : 6)	NC score	0.761111 (rank : 4)
Query Neighborhood Hits	83	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

ATM_HUMAN
θ value	1.32601e-43 (rank : 7)	NC score	0.732260 (rank : 7)
Query Neighborhood Hits	83	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
θ value	2.95404e-43 (rank : 8)	NC score	0.728033 (rank : 8)
Query Neighborhood Hits	83	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

PRKDC_MOUSE
θ value	5.21438e-40 (rank : 9)	NC score	0.701475 (rank : 9)
Query Neighborhood Hits	83	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
θ value	5.96599e-36 (rank : 10)	NC score	0.688724 (rank : 10)
Query Neighborhood Hits	83	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

TRRAP_HUMAN
θ value	7.09661e-13 (rank : 11)	NC score	0.415045 (rank : 20)
Query Neighborhood Hits	83	Target Neighborhood Hits	117	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3C3_HUMAN
θ value	1.58096e-12 (rank : 12)	NC score	0.517949 (rank : 11)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
θ value	6.00763e-12 (rank : 13)	NC score	0.516531 (rank : 12)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

TRRAP_MOUSE
θ value	1.74796e-11 (rank : 14)	NC score	0.416414 (rank : 19)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

PK3CD_MOUSE
θ value	1.9326e-10 (rank : 15)	NC score	0.436007 (rank : 13)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
θ value	5.62301e-10 (rank : 16)	NC score	0.433701 (rank : 14)
Query Neighborhood Hits	83	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

P3C2A_MOUSE
θ value	6.21693e-09 (rank : 17)	NC score	0.355569 (rank : 28)
Query Neighborhood Hits	83	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
θ value	1.06045e-08 (rank : 18)	NC score	0.352607 (rank : 29)
Query Neighborhood Hits	83	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

PK3CB_HUMAN
θ value	8.97725e-08 (rank : 19)	NC score	0.433447 (rank : 16)
Query Neighborhood Hits	83	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_MOUSE
θ value	8.97725e-08 (rank : 20)	NC score	0.433622 (rank : 15)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CA_HUMAN
θ value	1.53129e-07 (rank : 21)	NC score	0.397926 (rank : 23)
Query Neighborhood Hits	83	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_HUMAN
θ value	1.99992e-07 (rank : 22)	NC score	0.389478 (rank : 27)
Query Neighborhood Hits	83	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2G_MOUSE
θ value	1.99992e-07 (rank : 23)	NC score	0.395178 (rank : 25)
Query Neighborhood Hits	83	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PK3CA_MOUSE
θ value	1.99992e-07 (rank : 24)	NC score	0.397375 (rank : 24)
Query Neighborhood Hits	83	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PI4KB_HUMAN
θ value	5.81887e-07 (rank : 25)	NC score	0.428972 (rank : 17)
Query Neighborhood Hits	83	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
θ value	2.21117e-06 (rank : 26)	NC score	0.423504 (rank : 18)
Query Neighborhood Hits	83	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

P3C2B_HUMAN
θ value	3.77169e-06 (rank : 27)	NC score	0.326164 (rank : 30)
Query Neighborhood Hits	83	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

PI4KA_HUMAN
θ value	2.44474e-05 (rank : 28)	NC score	0.391443 (rank : 26)
Query Neighborhood Hits	83	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

PK3CG_HUMAN
θ value	0.000270298 (rank : 29)	NC score	0.405300 (rank : 21)
Query Neighborhood Hits	83	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

CAND2_HUMAN
θ value	0.00134147 (rank : 30)	NC score	0.109219 (rank : 36)
Query Neighborhood Hits	83	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

PK3CG_MOUSE
θ value	0.00228821 (rank : 31)	NC score	0.399444 (rank : 22)
Query Neighborhood Hits	83	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

IPO4_HUMAN
θ value	0.00298849 (rank : 32)	NC score	0.132996 (rank : 31)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO4_MOUSE
θ value	0.00869519 (rank : 33)	NC score	0.126034 (rank : 32)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

GCN1L_HUMAN
θ value	0.0148317 (rank : 34)	NC score	0.113080 (rank : 35)
Query Neighborhood Hits	83	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

IMB1_MOUSE
θ value	0.0148317 (rank : 35)	NC score	0.116116 (rank : 33)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
θ value	0.0193708 (rank : 36)	NC score	0.114641 (rank : 34)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	18
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

SPAG6_HUMAN
θ value	0.0252991 (rank : 37)	NC score	0.085500 (rank : 37)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

2AAB_HUMAN
θ value	0.0330416 (rank : 38)	NC score	0.056673 (rank : 46)
Query Neighborhood Hits	83	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

TLN1_MOUSE
θ value	0.0736092 (rank : 39)	NC score	0.040209 (rank : 50)
Query Neighborhood Hits	83	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

SPAG6_MOUSE
θ value	0.21417 (rank : 40)	NC score	0.072622 (rank : 41)
Query Neighborhood Hits	83	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

NEB1_HUMAN
θ value	0.279714 (rank : 41)	NC score	0.017542 (rank : 60)
Query Neighborhood Hits	83	Target Neighborhood Hits	829	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

TNPO1_HUMAN
θ value	0.47712 (rank : 42)	NC score	0.061326 (rank : 45)
Query Neighborhood Hits	83	Target Neighborhood Hits	64	Shared Neighborhood Hits	15
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

TNPO1_MOUSE
θ value	0.47712 (rank : 43)	NC score	0.061332 (rank : 44)
Query Neighborhood Hits	83	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

IMB3_MOUSE
θ value	0.62314 (rank : 44)	NC score	0.070387 (rank : 42)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

CAND2_MOUSE
θ value	0.813845 (rank : 45)	NC score	0.073820 (rank : 40)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

CAND1_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.079579 (rank : 38)
Query Neighborhood Hits	83	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

CAND1_MOUSE
θ value	1.06291 (rank : 47)	NC score	0.077517 (rank : 39)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

IMB3_HUMAN
θ value	1.06291 (rank : 48)	NC score	0.067622 (rank : 43)
Query Neighborhood Hits	83	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

MSTRO_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.050226 (rank : 48)
Query Neighborhood Hits	83	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYG7, Q8N6K5	Gene names	MRO, B29, C18orf3
Domain Architecture	No domain graphic available
Description	Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29).

REST_MOUSE
θ value	1.38821 (rank : 50)	NC score	0.019939 (rank : 58)
Query Neighborhood Hits	83	Target Neighborhood Hits	1506	Shared Neighborhood Hits	16
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TLN1_HUMAN
θ value	1.38821 (rank : 51)	NC score	0.024728 (rank : 55)
Query Neighborhood Hits	83	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

DMD_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.014180 (rank : 65)
Query Neighborhood Hits	83	Target Neighborhood Hits	1111	Shared Neighborhood Hits	16
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

PTTG1_MOUSE
θ value	1.81305 (rank : 53)	NC score	0.054229 (rank : 47)
Query Neighborhood Hits	83	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

IPO7_HUMAN
θ value	2.36792 (rank : 54)	NC score	0.032119 (rank : 52)
Query Neighborhood Hits	83	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O95373, Q9H177, Q9NTE3	Gene names	IPO7, RANBP7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

IPO7_MOUSE
θ value	2.36792 (rank : 55)	NC score	0.032081 (rank : 53)
Query Neighborhood Hits	83	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EPL8, Q7TN09, Q7TQ63, Q8BKD8, Q8BYI0	Gene names	Ipo7, Ranbp7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

OSBL9_HUMAN
θ value	2.36792 (rank : 56)	NC score	0.016099 (rank : 63)
Query Neighborhood Hits	83	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

AFAM_HUMAN
θ value	3.0926 (rank : 57)	NC score	0.020105 (rank : 57)
Query Neighborhood Hits	83	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	P43652	Gene names	AFM, ALB2, ALBA
Domain Architecture
Description	Afamin precursor (Alpha-albumin) (Alpha-Alb).

EVPL_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.014941 (rank : 64)
Query Neighborhood Hits	83	Target Neighborhood Hits	952	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

IPO8_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.030219 (rank : 54)
Query Neighborhood Hits	83	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	O15397	Gene names	IPO8, RANBP8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

NOL1_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.037971 (rank : 51)
Query Neighborhood Hits	83	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

BAP1_MOUSE
θ value	4.03905 (rank : 61)	NC score	0.012773 (rank : 68)
Query Neighborhood Hits	83	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

MYPN_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.010834 (rank : 72)
Query Neighborhood Hits	83	Target Neighborhood Hits	418	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
θ value	4.03905 (rank : 63)	NC score	0.011292 (rank : 70)
Query Neighborhood Hits	83	Target Neighborhood Hits	421	Shared Neighborhood Hits	6
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

TRIPB_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.005836 (rank : 81)
Query Neighborhood Hits	83	Target Neighborhood Hits	1587	Shared Neighborhood Hits	11
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

VP13B_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.017217 (rank : 61)
Query Neighborhood Hits	83	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

BPA1_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.009273 (rank : 74)
Query Neighborhood Hits	83	Target Neighborhood Hits	1477	Shared Neighborhood Hits	15
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GOGA4_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.010967 (rank : 71)
Query Neighborhood Hits	83	Target Neighborhood Hits	1939	Shared Neighborhood Hits	14
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

HEAT2_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.049967 (rank : 49)
Query Neighborhood Hits	83	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

K0406_MOUSE
θ value	5.27518 (rank : 69)	NC score	0.024066 (rank : 56)
Query Neighborhood Hits	83	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

SPRE2_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.008942 (rank : 76)
Query Neighborhood Hits	83	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

USP9X_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.013167 (rank : 67)
Query Neighborhood Hits	83	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

USP9X_MOUSE
θ value	5.27518 (rank : 72)	NC score	0.013216 (rank : 66)
Query Neighborhood Hits	83	Target Neighborhood Hits	171	Shared Neighborhood Hits	5
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

AP1G2_HUMAN
θ value	6.88961 (rank : 73)	NC score	0.009971 (rank : 73)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

PHF3_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.016319 (rank : 62)
Query Neighborhood Hits	83	Target Neighborhood Hits	419	Shared Neighborhood Hits	6
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

ACE_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.008798 (rank : 77)
Query Neighborhood Hits	83	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	P09470, Q6GTS2	Gene names	Ace, Dcp1
Domain Architecture
Description	Angiotensin-converting enzyme, somatic isoform precursor (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) [Contains: Angiotensin- converting enzyme, somatic isoform, soluble form].

APC_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.006435 (rank : 80)
Query Neighborhood Hits	83	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

AT2A1_MOUSE
θ value	8.99809 (rank : 77)	NC score	0.002325 (rank : 83)
Query Neighborhood Hits	83	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R429	Gene names	Atp2a1
Domain Architecture	No domain graphic available
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).

GRP3_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.008707 (rank : 78)
Query Neighborhood Hits	83	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

IPP2_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.019392 (rank : 59)
Query Neighborhood Hits	83	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P41236	Gene names	PPP1R2, IPP2
Domain Architecture
Description	Protein phosphatase inhibitor 2 (IPP-2).

KIRR2_MOUSE
θ value	8.99809 (rank : 80)	NC score	0.004673 (rank : 82)
Query Neighborhood Hits	83	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

RIB1_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.009173 (rank : 75)
Query Neighborhood Hits	83	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q91YQ5, Q3U985	Gene names	Rpn1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

SYNE2_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.012603 (rank : 69)
Query Neighborhood Hits	83	Target Neighborhood Hits	1323	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TKT_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.007872 (rank : 79)
Query Neighborhood Hits	83	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P40142	Gene names	Tkt
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK) (P68).

Hits sorted by NC score

FRAP_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	83	Target Neighborhood Hits	83	Shared Neighborhood Hits	83
SwissProt Accessions	P42345, Q6LE87, Q96QG3, Q9Y4I3	Gene names	FRAP1, FRAP, FRAP2
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

FRAP_MOUSE
NC score	0.999011 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	83	Target Neighborhood Hits	77	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JLN9, Q811J5, Q9CST1	Gene names	Frap1, Frap
Domain Architecture
Description	FKBP12-rapamycin complex-associated protein (FK506-binding protein 12- rapamycin complex-associated protein 1) (Rapamycin target protein) (RAPT1) (Mammalian target of rapamycin) (mTOR).

ATR_HUMAN
NC score	0.763938 (rank : 3)	θ value	1.91031e-50 (rank : 5)
Query Neighborhood Hits	83	Target Neighborhood Hits	71	Shared Neighborhood Hits	34
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

ATR_MOUSE
NC score	0.761111 (rank : 4)	θ value	8.02596e-49 (rank : 6)
Query Neighborhood Hits	83	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JKK8	Gene names	Atr
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein).

SMG1_MOUSE
NC score	0.740484 (rank : 5)	θ value	5.92465e-60 (rank : 3)
Query Neighborhood Hits	83	Target Neighborhood Hits	212	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BKX6, Q5DU42, Q6ZQC0, Q8BLU4, Q8BWJ5, Q8BXD3	Gene names	Smg1, Kiaa0421
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1).

SMG1_HUMAN
NC score	0.734174 (rank : 6)	θ value	1.01059e-59 (rank : 4)
Query Neighborhood Hits	83	Target Neighborhood Hits	231	Shared Neighborhood Hits	35
SwissProt Accessions	Q96Q15, O43305, Q13284, Q8NFX2, Q96QV0, Q96RW3	Gene names	SMG1, ATX, KIAA0421, LIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SMG1 (EC 2.7.11.1) (SMG-1) (hSMG-1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (61E3.4).

ATM_HUMAN
NC score	0.732260 (rank : 7)	θ value	1.32601e-43 (rank : 7)
Query Neighborhood Hits	83	Target Neighborhood Hits	78	Shared Neighborhood Hits	32
SwissProt Accessions	Q13315, O15429, Q12758, Q16551, Q93007, Q9NP02, Q9UCX7	Gene names	ATM
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T, mutated).

ATM_MOUSE
NC score	0.728033 (rank : 8)	θ value	2.95404e-43 (rank : 8)
Query Neighborhood Hits	83	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q62388	Gene names	Atm
Domain Architecture
Description	Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T, mutated homolog).

PRKDC_MOUSE
NC score	0.701475 (rank : 9)	θ value	5.21438e-40 (rank : 9)
Query Neighborhood Hits	83	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

PRKDC_HUMAN
NC score	0.688724 (rank : 10)	θ value	5.96599e-36 (rank : 10)
Query Neighborhood Hits	83	Target Neighborhood Hits	93	Shared Neighborhood Hits	31
SwissProt Accessions	P78527, P78528, Q13327, Q13337, Q14175, Q59H99, Q7Z611, Q96SE6, Q9UME3	Gene names	PRKDC
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (DNPK1) (p460).

PK3C3_HUMAN
NC score	0.517949 (rank : 11)	θ value	1.58096e-12 (rank : 12)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NEB9, Q15134	Gene names	PIK3C3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3) (Phosphatidylinositol 3-kinase p100 subunit).

PK3C3_MOUSE
NC score	0.516531 (rank : 12)	θ value	6.00763e-12 (rank : 13)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PF93, Q8R3S8	Gene names	Pik3c3
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137) (PtdIns-3-kinase type 3) (PI3-kinase type 3) (PI3K type 3) (Phosphoinositide-3-kinase class 3).

PK3CD_MOUSE
NC score	0.436007 (rank : 13)	θ value	1.9326e-10 (rank : 15)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	28
SwissProt Accessions	O35904	Gene names	Pik3cd
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CD_HUMAN
NC score	0.433701 (rank : 14)	θ value	5.62301e-10 (rank : 16)
Query Neighborhood Hits	83	Target Neighborhood Hits	40	Shared Neighborhood Hits	28
SwissProt Accessions	O00329, O15445	Gene names	PIK3CD
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit delta) (PtdIns-3- kinase p110) (PI3K) (p110delta).

PK3CB_MOUSE
NC score	0.433622 (rank : 15)	θ value	8.97725e-08 (rank : 20)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BTI9	Gene names	Pik3cb
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PK3CB_HUMAN
NC score	0.433447 (rank : 16)	θ value	8.97725e-08 (rank : 19)
Query Neighborhood Hits	83	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	P42338	Gene names	PIK3CB
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform (EC 2.7.1.153) (PI3-kinase p110 subunit beta) (PtdIns-3-kinase p110) (PI3K) (PI3Kbeta).

PI4KB_HUMAN
NC score	0.428972 (rank : 17)	θ value	5.81887e-07 (rank : 25)
Query Neighborhood Hits	83	Target Neighborhood Hits	79	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PI4KB_MOUSE
NC score	0.423504 (rank : 18)	θ value	2.21117e-06 (rank : 26)
Query Neighborhood Hits	83	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

TRRAP_MOUSE
NC score	0.416414 (rank : 19)	θ value	1.74796e-11 (rank : 14)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q80YV3, Q8C0Z5, Q8K104	Gene names	Trrap
Domain Architecture
Description	Transformation/transcription domain-associated protein (Tra1 homolog).

TRRAP_HUMAN
NC score	0.415045 (rank : 20)	θ value	7.09661e-13 (rank : 11)
Query Neighborhood Hits	83	Target Neighborhood Hits	117	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

PK3CG_HUMAN
NC score	0.405300 (rank : 21)	θ value	0.000270298 (rank : 29)
Query Neighborhood Hits	83	Target Neighborhood Hits	41	Shared Neighborhood Hits	28
SwissProt Accessions	P48736, Q8IV23, Q9BZC8	Gene names	PIK3CG
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CG_MOUSE
NC score	0.399444 (rank : 22)	θ value	0.00228821 (rank : 31)
Query Neighborhood Hits	83	Target Neighborhood Hits	43	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JHG7	Gene names	Pik3cg, Pi3kg1
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K).

PK3CA_HUMAN
NC score	0.397926 (rank : 23)	θ value	1.53129e-07 (rank : 21)
Query Neighborhood Hits	83	Target Neighborhood Hits	45	Shared Neighborhood Hits	28
SwissProt Accessions	P42336, Q99762	Gene names	PIK3CA
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

PK3CA_MOUSE
NC score	0.397375 (rank : 24)	θ value	1.99992e-07 (rank : 24)
Query Neighborhood Hits	83	Target Neighborhood Hits	48	Shared Neighborhood Hits	28
SwissProt Accessions	P42337	Gene names	Pik3ca
Domain Architecture
Description	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3- kinase p110) (PI3K).

P3C2G_MOUSE
NC score	0.395178 (rank : 25)	θ value	1.99992e-07 (rank : 23)
Query Neighborhood Hits	83	Target Neighborhood Hits	113	Shared Neighborhood Hits	29
SwissProt Accessions	O70167, O70168	Gene names	Pik3c2g
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

PI4KA_HUMAN
NC score	0.391443 (rank : 26)	θ value	2.44474e-05 (rank : 28)
Query Neighborhood Hits	83	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	P42356, Q7Z625, Q9UPG2	Gene names	PIK4CA, PIK4
Domain Architecture
Description	Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67) (PI4-kinase alpha) (PtdIns-4-kinase alpha) (PI4K-alpha).

P3C2G_HUMAN
NC score	0.389478 (rank : 27)	θ value	1.99992e-07 (rank : 22)
Query Neighborhood Hits	83	Target Neighborhood Hits	92	Shared Neighborhood Hits	28
SwissProt Accessions	O75747	Gene names	PIK3C2G
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-gamma) (PtdIns-3-kinase C2 gamma) (PI3K-C2gamma).

P3C2A_MOUSE
NC score	0.355569 (rank : 28)	θ value	6.21693e-09 (rank : 17)
Query Neighborhood Hits	83	Target Neighborhood Hits	181	Shared Neighborhood Hits	29
SwissProt Accessions	Q61194, Q61182	Gene names	Pik3c2a, Cpk
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha) (Cpk-m) (p170).

P3C2A_HUMAN
NC score	0.352607 (rank : 29)	θ value	1.06045e-08 (rank : 18)
Query Neighborhood Hits	83	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	O00443	Gene names	PIK3C2A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-alpha) (PtdIns-3-kinase C2 alpha) (PI3K-C2alpha).

P3C2B_HUMAN
NC score	0.326164 (rank : 30)	θ value	3.77169e-06 (rank : 27)
Query Neighborhood Hits	83	Target Neighborhood Hits	148	Shared Neighborhood Hits	28
SwissProt Accessions	O00750, O95666, Q5SW99	Gene names	PIK3C2B
Domain Architecture
Description	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide (EC 2.7.1.154) (Phosphoinositide 3-Kinase-C2-beta) (PtdIns-3-kinase C2 beta) (PI3K-C2beta) (C2-PI3K).

IPO4_HUMAN
NC score	0.132996 (rank : 31)	θ value	0.00298849 (rank : 32)
Query Neighborhood Hits	83	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TEX9, Q86TZ9, Q8NCG8, Q96SJ3, Q9BTI4, Q9H5L0	Gene names	IPO4, IMP4B, RANBP4
Domain Architecture
Description	Importin-4 (Importin 4b) (Imp4b) (Ran-binding protein 4) (RanBP4).

IPO4_MOUSE
NC score	0.126034 (rank : 32)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	16
SwissProt Accessions	Q8VI75, Q3TBW0, Q99J52	Gene names	Ipo4, Imp4a, Ranbp4
Domain Architecture	No domain graphic available
Description	Importin-4 (Importin 4a) (Imp4a) (Ran-binding protein 4) (RanBP4).

IMB1_MOUSE
NC score	0.116116 (rank : 33)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	P70168, Q62117	Gene names	Kpnb1, Impnb
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Pore targeting complex 97 kDa subunit) (PTAC97) (SCG).

IMB1_HUMAN
NC score	0.114641 (rank : 34)	θ value	0.0193708 (rank : 36)
Query Neighborhood Hits	83	Target Neighborhood Hits	51	Shared Neighborhood Hits	18
SwissProt Accessions	Q14974, Q14637, Q96J27	Gene names	KPNB1, NTF97
Domain Architecture
Description	Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor P97) (Importin 90).

GCN1L_HUMAN
NC score	0.113080 (rank : 35)	θ value	0.0148317 (rank : 34)
Query Neighborhood Hits	83	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	Q92616, O95001, O95651, Q6P2S3, Q86X65, Q8N5I5, Q8WU80, Q99736, Q9UE60	Gene names	GCN1L1, KIAA0219
Domain Architecture	No domain graphic available
Description	GCN1-like protein 1 (HsGCN1).

CAND2_HUMAN
NC score	0.109219 (rank : 36)	θ value	0.00134147 (rank : 30)
Query Neighborhood Hits	83	Target Neighborhood Hits	40	Shared Neighborhood Hits	15
SwissProt Accessions	O75155	Gene names	CAND2, KIAA0667
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2).

SPAG6_HUMAN
NC score	0.085500 (rank : 37)	θ value	0.0252991 (rank : 37)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	O75602, Q5VUX5, Q5VUX6, Q5VUX7, Q6FI74, Q8NHQ6	Gene names	SPAG6, PF16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Sperm flagellar protein) (Repro-SA-1).

CAND1_HUMAN
NC score	0.079579 (rank : 38)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	83	Target Neighborhood Hits	45	Shared Neighborhood Hits	15
SwissProt Accessions	Q86VP6, O94918, Q6PIY4, Q8NDJ4, Q96JZ9, Q96T19, Q9BTC4, Q9H0G2, Q9P0H7, Q9UF85	Gene names	CAND1, KIAA0829, TIP120, TIP120A
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1) (TBP-interacting protein TIP120A) (TBP-interacting protein of 120 kDa A).

CAND1_MOUSE
NC score	0.077517 (rank : 39)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	83	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQ38, Q6PFR0, Q9CV45	Gene names	Cand1, D10Ertd516e, Kiaa0829
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (p120 CAND1).

CAND2_MOUSE
NC score	0.073820 (rank : 40)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZQ73, Q6PHT7	Gene names	Cand2, Kiaa0667, Tip120b
Domain Architecture	No domain graphic available
Description	Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (p120 CAND2) (TBP-interacting protein TIP120B) (TBP-interacting protein of 120 kDa B).

SPAG6_MOUSE
NC score	0.072622 (rank : 41)	θ value	0.21417 (rank : 40)
Query Neighborhood Hits	83	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q9JLI7, Q8K461	Gene names	Spag6, Pf16
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 6 (PF16 protein homolog) (Axoneme central apparatus protein).

IMB3_MOUSE
NC score	0.070387 (rank : 42)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	83	Target Neighborhood Hits	58	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BKC5, Q3TEG2, Q7TQC6, Q9EQ30	Gene names	Ranbp5, Kpnb3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

IMB3_HUMAN
NC score	0.067622 (rank : 43)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	83	Target Neighborhood Hits	57	Shared Neighborhood Hits	18
SwissProt Accessions	O00410, O15257	Gene names	RANBP5, KPNB3
Domain Architecture
Description	Importin beta-3 (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5).

TNPO1_MOUSE
NC score	0.061332 (rank : 44)	θ value	0.47712 (rank : 43)
Query Neighborhood Hits	83	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BFY9, Q8C0S3, Q8K2E7	Gene names	Tnpo1, Kpnb2
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2).

TNPO1_HUMAN
NC score	0.061326 (rank : 45)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	83	Target Neighborhood Hits	64	Shared Neighborhood Hits	15
SwissProt Accessions	Q92973, Q92957, Q92975	Gene names	TNPO1, KPNB2, MIP1, TRN
Domain Architecture
Description	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP).

2AAB_HUMAN
NC score	0.056673 (rank : 46)	θ value	0.0330416 (rank : 38)
Query Neighborhood Hits	83	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	P30154, O75620	Gene names	PPP2R1B
Domain Architecture
Description	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A, subunit A, PR65-beta isoform) (PP2A, subunit A, R1-beta isoform).

PTTG1_MOUSE
NC score	0.054229 (rank : 47)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	83	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQJ7, O88887, Q9Z2E6	Gene names	Pttg1, Pttg
Domain Architecture
Description	Securin (Pituitary tumor-transforming protein 1).

MSTRO_HUMAN
NC score	0.050226 (rank : 48)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	83	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYG7, Q8N6K5	Gene names	MRO, B29, C18orf3
Domain Architecture	No domain graphic available
Description	Protein maestro (Male-specific transcription in the developing reproductive organs) (Protein B29).

HEAT2_HUMAN
NC score	0.049967 (rank : 49)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	83	Target Neighborhood Hits	36	Shared Neighborhood Hits	10
SwissProt Accessions	Q86Y56, Q69YL1, Q96FI9, Q9NX75	Gene names	HEATR2
Domain Architecture	No domain graphic available
Description	HEAT repeat-containing protein 2.

TLN1_MOUSE
NC score	0.040209 (rank : 50)	θ value	0.0736092 (rank : 39)
Query Neighborhood Hits	83	Target Neighborhood Hits	213	Shared Neighborhood Hits	7
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

NOL1_HUMAN
NC score	0.037971 (rank : 51)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	83	Target Neighborhood Hits	74	Shared Neighborhood Hits	3
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

IPO7_HUMAN
NC score	0.032119 (rank : 52)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	83	Target Neighborhood Hits	33	Shared Neighborhood Hits	6
SwissProt Accessions	O95373, Q9H177, Q9NTE3	Gene names	IPO7, RANBP7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

IPO7_MOUSE
NC score	0.032081 (rank : 53)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	83	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	Q9EPL8, Q7TN09, Q7TQ63, Q8BKD8, Q8BYI0	Gene names	Ipo7, Ranbp7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

IPO8_HUMAN
NC score	0.030219 (rank : 54)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	83	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	O15397	Gene names	IPO8, RANBP8
Domain Architecture
Description	Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8).

TLN1_HUMAN
NC score	0.024728 (rank : 55)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	83	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

K0406_MOUSE
NC score	0.024066 (rank : 56)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	83	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q91V83, Q9CSY0	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA0406 homolog.

AFAM_HUMAN
NC score	0.020105 (rank : 57)	θ value	3.0926 (rank : 57)
Query Neighborhood Hits	83	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	P43652	Gene names	AFM, ALB2, ALBA
Domain Architecture
Description	Afamin precursor (Alpha-albumin) (Alpha-Alb).

REST_MOUSE
NC score	0.019939 (rank : 58)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	83	Target Neighborhood Hits	1506	Shared Neighborhood Hits	16
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

IPP2_HUMAN
NC score	0.019392 (rank : 59)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	83	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	P41236	Gene names	PPP1R2, IPP2
Domain Architecture
Description	Protein phosphatase inhibitor 2 (IPP-2).

NEB1_HUMAN
NC score	0.017542 (rank : 60)	θ value	0.279714 (rank : 41)
Query Neighborhood Hits	83	Target Neighborhood Hits	829	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

VP13B_HUMAN
NC score	0.017217 (rank : 61)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	83	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z7G8, Q709C6, Q709C7, Q7Z7G4, Q7Z7G5, Q7Z7G6, Q7Z7G7, Q8NB77, Q9NWV1, Q9Y4E7	Gene names	VPS13B, CHS1, COH1, KIAA0532
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1).

PHF3_HUMAN
NC score	0.016319 (rank : 62)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	83	Target Neighborhood Hits	419	Shared Neighborhood Hits	6
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

OSBL9_HUMAN
NC score	0.016099 (rank : 63)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	83	Target Neighborhood Hits	138	Shared Neighborhood Hits	4
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

EVPL_MOUSE
NC score	0.014941 (rank : 64)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	83	Target Neighborhood Hits	952	Shared Neighborhood Hits	14
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

DMD_MOUSE
NC score	0.014180 (rank : 65)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	83	Target Neighborhood Hits	1111	Shared Neighborhood Hits	16
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

USP9X_MOUSE
NC score	0.013216 (rank : 66)	θ value	5.27518 (rank : 72)
Query Neighborhood Hits	83	Target Neighborhood Hits	171	Shared Neighborhood Hits	5
SwissProt Accessions	P70398, Q62497	Gene names	Usp9x, Fafl, Fam
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin carboxyl-terminal hydrolase FAM) (Fat facets homolog).

USP9X_HUMAN
NC score	0.013167 (rank : 67)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	83	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q93008, O75550, Q8WWT3, Q8WX12	Gene names	USP9X, DFFRX, USP9
Domain Architecture
Description	Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.1.2.15) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific-processing protease FAF-X) (Deubiquitinating enzyme FAF-X) (Fat facets protein-related, X- linked) (Ubiquitin-specific protease 9, X chromosome).

BAP1_MOUSE
NC score	0.012773 (rank : 68)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	83	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PU7, Q6ZQE6	Gene names	Bap1, Kiaa0272
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1- associated protein 1) (Ubiquitin C-terminal hydrolase X4) (UCH-X4).

SYNE2_HUMAN
NC score	0.012603 (rank : 69)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	83	Target Neighborhood Hits	1323	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MYPN_MOUSE
NC score	0.011292 (rank : 70)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	83	Target Neighborhood Hits	421	Shared Neighborhood Hits	6
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

GOGA4_MOUSE
NC score	0.010967 (rank : 71)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	83	Target Neighborhood Hits	1939	Shared Neighborhood Hits	14
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MYPN_HUMAN
NC score	0.010834 (rank : 72)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	83	Target Neighborhood Hits	418	Shared Neighborhood Hits	5
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

AP1G2_HUMAN
NC score	0.009971 (rank : 73)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	83	Target Neighborhood Hits	44	Shared Neighborhood Hits	4
SwissProt Accessions	O75843, O75504	Gene names	AP1G2
Domain Architecture
Description	AP-1 complex subunit gamma-2 (Adapter-related protein complex 1 gamma- 2 subunit) (Gamma2-adaptin) (Adaptor protein complex AP-1 gamma-2 subunit) (G2ad).

BPA1_MOUSE
NC score	0.009273 (rank : 74)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	83	Target Neighborhood Hits	1477	Shared Neighborhood Hits	15
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

RIB1_MOUSE
NC score	0.009173 (rank : 75)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	83	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q91YQ5, Q3U985	Gene names	Rpn1
Domain Architecture
Description	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I).

SPRE2_MOUSE
NC score	0.008942 (rank : 76)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	83	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

ACE_MOUSE
NC score	0.008798 (rank : 77)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	83	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	P09470, Q6GTS2	Gene names	Ace, Dcp1
Domain Architecture
Description	Angiotensin-converting enzyme, somatic isoform precursor (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) [Contains: Angiotensin- converting enzyme, somatic isoform, soluble form].

GRP3_HUMAN
NC score	0.008707 (rank : 78)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	83	Target Neighborhood Hits	131	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

TKT_MOUSE
NC score	0.007872 (rank : 79)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	83	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	P40142	Gene names	Tkt
Domain Architecture
Description	Transketolase (EC 2.2.1.1) (TK) (P68).

APC_MOUSE
NC score	0.006435 (rank : 80)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	83	Target Neighborhood Hits	441	Shared Neighborhood Hits	10
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

TRIPB_HUMAN
NC score	0.005836 (rank : 81)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	83	Target Neighborhood Hits	1587	Shared Neighborhood Hits	11
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

KIRR2_MOUSE
NC score	0.004673 (rank : 82)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	83	Target Neighborhood Hits	326	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

AT2A1_MOUSE
NC score	0.002325 (rank : 83)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	83	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R429	Gene names	Atp2a1
Domain Architecture	No domain graphic available
Description	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (EC 3.6.3.8) (Calcium pump 1) (SERCA1) (SR Ca(2+)-ATPase 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase).